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Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gum-polyvinylpyrollidone/carbopol and were characterized by 13 C NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined. Hydrogel wound dressings were found non-haemolytic, antioxidant and mucoadhesive in nature. Release of drug occurred through non-Fickian diffusion mechanism and release profile best fitted in Higuchi model., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Present article discusses the synthesis, characterization, biodegradation, network parameter and drug release of gum acacia-crosslinked-carbopol hydrogel wound dressing. Polymers have been characterized by C solid state nuclear magnetic resonance spectroscopy, elemental analysis, cryo-scanning electron microscopy, atomic force microscopy, thermogravimetric analysis, differential thermal analysis, differential thermogravimetry, and differential scanning calorimetry studies. Network parameters of hydrogel wound dressings such as polymer volume fraction in the swollen state φ, Flory-Huggins interaction parameter χ, molecular weight of the polymer chain between two neighboring cross links M , crosslink density ρ and the corresponding mesh size ξ have also been determined. Different in vitro release kinetic models (zero order, first order, Higuchi square root law, Korsmeyer-Peppas, and Hixson-Crowell cube root models) have been applied on the drug release profile. The release of antibiotic drug moxifloxacin from the drug loaded hydrogel matrix occurred through non-Fickian diffusion mechanism and release profile best fitted in the Korsmeyer-Peppas model. Semi-contact mode atomic force microscopic imaging showed that rough surface with root mean square roughness 82.868 nm of the polymer films. [ABSTRACT FROM AUTHOR]

Keeping in view the antimicrobial nature of polyvinylimidazole, the antioxidant property of gum acacia, the mucoadhesive and gel-forming nature of Carbopol, the anesthetic action of lidocaine, and the antimicrobial action of gentamicin, in the present work, an attempt was made to prepare lidocaine and gentamicin loaded gum acacia-Carbopol-polyvinylimidazole based hydrogel wound dressings for better wound healing. These hydrogel dressings were characterized by 13C NMR, FTIR, SEM, cryo-SEM, AFM, XRD, DSC, swelling, and network parameter studies. Some properties of wound dressings were also determined which include the following: hemolysis, hemostatic potential, oxygen permeability, water vapor transmission rate, antioxidant activity, mucoadhesion, protein adsorption, degradation studies, antimicrobial properties (against Pseudomonas aeruginosa bacteria), microbial penetration, mechanical properties (tensile strength, burst strength, resilience, relaxation, folding endurance and gel strength) drug release, and histological studies. The synergic effects of the mucoadhesive, antimicrobial, and antioxidant nature of hydrogel dressings make them suitable candidate as wound dressing material. [ABSTRACT FROM AUTHOR]