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Humic acid is a group of molecules which are eco-benign, inexpensive, readily attainable, high-molecular-weight, natural acidic organic polymer. In our current protocol a simple, facile, and robust single-pot three-component synthesis of 1-amidoalkyl-2-naphthols and 1-thioamidoalkyl-2-naphthols using humic acid as an efficient catalyst in water has been described. The method, we reported, has several advantages such as moderate to excellent yields, easy work-up procedure, mild reaction conditions, use of water as a green solvent, and a commercially available, nontoxic, and reusable catalyst. [ABSTRACT FROM AUTHOR]

Glycerol, a green, bio‐degradable, benign solvent has been recognized to act as a highly efficient medium for the catalyst free synthesis of a vast range of highly functionalized thioamide by modified Willgerodt‐Kindler Reaction and 4H‐thiopyran via one‐pot multi‐component synthesis from easily accessible precursors. These protocols avoid hardnosed reaction conditions and proceed without any metal catalyst or toxic acid or solvent. In addition, these protocols have numerous advantages such as shorter reaction time, high yield and excellent functional group tolerance. Further the solvent can be recovered and reused at the end of the reaction which makes this methodology inexpensive, greener and environmentally safe protocol. [ABSTRACT FROM AUTHOR]