1. Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan.
- Author
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Kusumi, E., Kami, M., Kanda, Y., Murashige, N., Kishi, Y., Suzuki, R., Takeuchi, K., Tanimoto, T. E., Mori, T., Muta, K., Tamaki, T., Tanaka, Y., Ogawa, H., Yamane, T., Taniguchi, S., and Takaue, Y.
- Subjects
STEM cell transplantation ,HEMATOPOIETIC stem cells ,GRAFT versus host disease ,AUTOTRANSPLANTATION ,LYMPHOPROLIFERATIVE disorders ,TRANSPLANTATION immunology - Abstract
Summary:We conducted a nation-wide survey of 112 adult Japanese patients who underwent reduced-intensity stem cell transplantation (RIST) from 1999 to 2002. Underlying diseases included indolent (n=45), aggressive (n=58) and highly aggressive lymphomas (n=9). Median age of the patients was 49 years. A total of 40 patients (36%) had relapsed diseases after autologous stem cell transplantation and 36 patients (32%) had received radiotherapy. RIST regimens were fludarabine-based (n=95), low-dose total body irradiation-based (n=6) and others (n=11). Cumulative incidences of grade II–IV acute graft-versus-host disease (GVHD) and chronic GVHD were, respectively, 49 and 59%. Cumulative incidences of progression and progression-free mortality were 18 and 25%, respectively. With a median follow-up of 23.9 months, 3-year overall survival rates were 59%. A multivariate analysis identified three significant factors for progression, which are history of radiation (relative risk (RR) 3.45, confidential interval (CI) 1.12–10.0, P=0.03), central nervous system involvement (RR 6.25, CI 2.08–20.0, P=0.001) and development of GVHD (RR 0.28, CI 0.090–0.86, P=0.026). RIST may have decreased the rate of transplant-related mortality, and GVHD may have induced a graft-versus-lymphoma effect. However, whether or not these potential benefits can be directly translated into improved patient survival should be evaluated in further studies.Bone Marrow Transplantation (2005) 36, 205–213. doi:10.1038/sj.bmt.1705027; published online 6 June 2005 [ABSTRACT FROM AUTHOR]
- Published
- 2005
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