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Your search keyword '"Alessandrini, C."' showing total 3 results
Start Over Author "Alessandrini, C." Topic gout
3 results on '"Alessandrini, C."'

1. [Hypothesis on the probable mechanism of auto-limitation of acute attacks of gout].

Author

Calabria AA, Parrini E, Bacarelli MR, Alessandrini C, Cavallo G, and Marcolongo R

Subjects
Calorimetry, Crystallization, Free Radicals, Gout blood, Humans, Microscopy, Electron, Scanning, Models, Biological, Neutrophils metabolism, Oxygen, Spectrophotometry, Superoxides blood, Uric Acid blood, Gout physiopathology
Published
1986

2. The "switch-off" mechanism of spontaneous resolution of acute gout attack.

Author

Marcolongo R, Calabria AA, Lalumera M, Gerli R, Alessandrini C, and Cavallo G

Subjects
Calorimetry, Crystallization, Humans, Lymphocytes metabolism, Microscopy, Electron, Scanning, Remission, Spontaneous, Superoxides metabolism, Superoxides pharmacology, Uric Acid metabolism, Acute-Phase Reaction physiopathology, Gout physiopathology, Inflammation physiopathology
Abstract

Urate crystal size change and the modification of coated proteins by oxygen radicals released by stimulated polymorphonuclear cells (PMN) could represent a likely "switch-off" mechanism of the spontaneous resolution of acute gout attack. The absorption spectra and the uric acid, allantoin and urea concentrations were determined before and after in vitro exposition of monosodium urate (MSU) crystals to superoxide anion (O2) photochemically generated. The results showed a complete dissolution of MSU crystals after incubation under O2-, with decrease of uric acid and increase of allantoin and urea concentrations. Our results were confirmed by polarizing, electron microscopy and calorimetric techniques. The results obtained seem to confirm that the spontaneous resolution of acute gout attack could be attributed to the dissolving effect on urate crystals and the modification of coated proteins by O2- released by phagocytizing PMN.

Published
1988

3. The 'Switch-Off' Mechanism of Spontaneous Resolution of Acute Gout Attack

Author

Cavallo G, Alessandrini C, A A Calabria, M Lalumera, Roberto Marcolongo, and Gerli R

Subjects
medicine.medical_specialty, Superoxide, business.industry, Radical, chemistry.chemical_element, medicine.disease, Oxygen, law.invention, Gout, chemistry.chemical_compound, Allantoin, Endocrinology, chemistry, law, Internal medicine, medicine, Urea, Uric acid, Electron microscope, business, Nuclear chemistry
Abstract

Urate crystal size change and the modification of coated proteins by oxygen radicals released by stimulated polymorphonuclear cells (PMN) could represent a likely "switch-off" mechanism of the spontaneous resolution of acute gout attack. The absorption spectra and the uric acid, allantoin and urea concentrations were determined before and after in vitro exposition of monosodium urate (MSU) crystals to superoxide anion (O2) photochemically generated. The results showed a complete dissolution of MSU crystals after incubation under O2-, with decrease of uric acid and increase of allantoin and urea concentrations. Our results were confirmed by polarizing, electron microscopy and calorimetric techniques. The results obtained seem to confirm that the spontaneous resolution of acute gout attack could be attributed to the dissolving effect on urate crystals and the modification of coated proteins by O2- released by phagocytizing PMN.

Published
1986
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