1. Goldfish brain and heart are well protected from Ni²⁺-induced oxidative stress.
- Author
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Kubrak OI, Poigner H, Husak VV, Rovenko BM, Meyer S, Abele D, and Lushchak VI
- Subjects
- Animals, Brain Chemistry drug effects, Metals metabolism, Water Pollutants, Chemical toxicity, Brain drug effects, Goldfish physiology, Heart drug effects, Myocardium metabolism, Nickel toxicity, Oxidants toxicity, Oxidative Stress drug effects
- Abstract
After 96 h goldfish exposure to 10, 25 or 50 mg/L of Ni(2+) no Ni accumulation was found in the brain, but lipid peroxide concentration was by 44% elevated in the brain, whereas carbonyl protein content was by 45-45% decreased in the heart. High molecular mass thiol concentration was enhanced by 30% in the heart, while in the brain low molecular mass thiol concentration increased by 28-88%. Superoxide dismutase activity was by 27% and 35% increased in the brain and heart, respectively. Glutathione peroxidase activity was lowered to 38% and 62% of control values in both tissues, whereas catalase activity was increased in the heart by 15-45%, accompanied by 18-29% decreased glutathione reductase activity. The disturbances of free radical processes in the brain and heart might result from Ni-induced injuries to other organs with more prominent changes in the heart, because of close contact of this organ with blood, whereas the blood-brain barrier seems to protect the brain., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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