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Start Over Author "Gharepapagh E" Topic gold standard (test)
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1. Dos and Don'ts that are Issued through Radiolabeling Process of DMSA (Dimercaptosuccinic Acid) by 99mTco4- as 99mTc-DMSA(III), the Gold Standard Radiopharmaceutical for Renal Cortical Scintigraphy

Author

Dabiri S, Mamaghani Ff, Gharepapagh E, and Fakhari A

Subjects
Biodistribution, medicine.diagnostic_test, business.industry, 99mTc-DMSA, Fatty liver, Gold standard (test), Scintigraphy, medicine.disease, Thin-layer chromatography, Dimercaptosuccinic acid, medicine, business, DMSA scan, Nuclear medicine, medicine.drug
Abstract

Objective: Since DMSA (Dimercaptosuccinic Acid) is an important and more sensitive kit in the realm of renal scintigraphy, in the course of this enormous study throughout five years, all quality control results from more than 500 Tc-99m radiolabeled DMSA kits and scans were studied to improve radiolabeling method through optimization of all involving parameters. Methods: Instant thin layer chromatography (ITLC) (support: ITLC-Silicic-acid (SA), solvent: n-Butanol Saturated with 0.3N HCl) were used to calculate %radiochemical purity (%Tc-99m DMSA). Data from ITLC and scans were investigated to obtain the optimized radiolabeling method so as to decrease background uptake particularly liver uptake. Results: Data suggested that if radiolabeling is performed under optimized involving parameters (Generator used day 2, SA=(15-20 mCi)/ (1cc) radiochemical purity=99.5% (Al2O3

Published
2018

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