1. Multimodal radiolabeled gold nanoparticle molecular probes: synthesis, imaging, and applications.
- Author
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Gao, Qinyue and Chen, Fei
- Subjects
- *
GOLD nanoparticles , *MOLECULAR probes , *RADIOACTIVE tracers , *RADIOLABELING , *DIAGNOSTIC imaging , *RADIOISOTOPES - Abstract
Recent years have witnessed increasing advances in gold nanoparticles (GNPs) for accurate and precise diagnosis and therapy. GNPs have great potential in translating into clinical nanomaterial-based products, predominantly attributed to their physicochemical and biological properties. Radiolabeling endows GNPs with high-sensitive imaging capacities in addition to providing potent therapeutic effects, which makes the development of radiolabeling nanotechnology highly desirable. In this review, we briefly describe the physicochemical properties of GNPs and radionuclides, then summarized radiolabeling methods utilized in radiolabeling GNPs, and discuss their whole-body pharmacokinetics and biodistribution. Finally, their current applications in clinical and molecular imaging and therapy are introduced. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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