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Your search keyword '"Komor R"' showing total 2 results
Start Over Author "Komor R" Topic glycosyltransferases
2 results on '"Komor R"'

1. Synthesis of fucosylated uridine conjugates as potential glycosyltransferase inhibitors.

Author

Komor K, Szeja W, Komor R, Pastuch-Gawołek G, and Thiem J

Subjects
Chromatography, Thin Layer, Enzyme Inhibitors chemistry, Enzyme Inhibitors pharmacology, Glycoconjugates chemistry, Glycoconjugates pharmacology, Magnetic Resonance Spectroscopy, Molecular Structure, Enzyme Inhibitors chemical synthesis, Fucose chemistry, Glycoconjugates chemical synthesis, Glycosyltransferases antagonists & inhibitors, Uridine chemistry
Published
2014

2. 5-Nitro-2-pyridyl-1-thioglucosides: application in synthesis of analogues of glycosyltransferases natural substrates.

Author

Pastuch G, Komor R, Grec M, and Szeja W

Subjects
Enzyme Inhibitors metabolism, Enzyme Inhibitors pharmacology, Glycosylation, Glycosyltransferases antagonists & inhibitors, Magnetic Resonance Spectroscopy, Molecular Structure, Oxidation-Reduction, Structure-Activity Relationship, Substrate Specificity, Thioglucosides metabolism, Thioglucosides pharmacology, Thiouridine metabolism, Thiouridine pharmacology, Enzyme Inhibitors chemical synthesis, Glycosyltransferases metabolism, Thioglucosides chemical synthesis, Thiouridine chemical synthesis
Abstract

5-Nitro-2-pyridyl-1-thioglucosides were used in synthesis of complex uridine derivatives (13-16) in two different sequences of reactions. In one route, the first step was glycosylation of selectively protected 5-nitro-2-pyridyl-1-thioglucoside 1 with two different glycosyl donors (5 or 6), next, the nitro group in aglycone of obtained disaccharides 7 or 8 was reduced and then obtained products 9 or 10 were condensed with uridine derivatives 3 or 4 using DMT-MM as condensing agent under microwave irradiation. In the second route, condensation and glycosylation reactions were applied in reverse order. As it turned up, a sequence of reactions affected the yield of final glycoconjugates 13-16 and depended on the type of uridine derivatives used.

Published
2010

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