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The chemical characterization study of an endemic plant, Haplanthodes neilgherryensis is (Wight) R.B. Majumdar from Western Ghats of India, resulted in to the isolation of a new flavanone glycoside, 5-hydroxy-7-methoxy-8-O- β -D-glucopyranosyl-2S-flavanone ( 1 ), along with 3 known flavonoids, 7-O-methyl dihydrowogonin ( 2 ), 7-O-methyl wogonin ( 3 ), andrographidine C ( 4 ). The structure of 1 was elucidated by using 1 D and 2 D NMR and HRMS experimental data, while for the known compounds, 1 H NMR and mass spectrometry data were compared with the reported literature. Compound 1 was tested in vitro to check the improvement in uptake of glucose by the L6 rat skeletal muscle tissues and the observed EC 50 value was 5.8 µM, while rosiglitazone showed EC 50 of 2.7 µM.

A new flavanone glycoside, (2 S )-dihydrooroxylin A 7- O -[ β -D-apiosyl(1 → 2)]- β -D-glucoside ( 1 ), and four known compounds ( 2-5 ) were isolated from Tournefortia sibirica L. The chemical structures of these compounds were determined by 1 D and 2 D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. These five compounds ( 1-5 ) were isolated from the family Boraginaceae for the first time. Anti-inflammatory effects of compounds ( 1-5 ) were evaluated in terms of inhibition of production of NO, TNF-α, and IL-6 in LPS-induced RAW 264.7 cells.

The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives ( 1, 2 ), a new flavanone glycoside ( 3 ), and six reported flavanones ( 4 ⁻ 9 ) were isolated and identified from the flowers of C. morifolium . The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents 1 ⁻ 8 were evaluated for their neuroprotective activity, and compounds 3 and 4 displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.

Here we are reporting a new bioactive flavanone glycoside. The compound having molecular formula C21H22O11, melting point 123-125°C, and ESI-MS m/z 451 was isolated from the methanolic extract of Tradescantia Spathacea Sw. Its characterization and structure elucidation was done with the help of various chemical degradation, color reactions, and spectral data like UV-Visible, FT-IR, electrospray ionization mass spectrometry technique, nuclear magnetic resonance spectroscopy, etc. It was recognized as 5,7,3'4'-tetrahydroxy flavanone 3'-O-D-mannopyranoside. This study was also designed to examine the efficacy of an isolated compound against various bacteria which are responsible for food spoilage and pathogens in humans. The organic flavanone glycoside of methanolic extract exhibited a promising antibacterial activity towards Escherichia coli (gram negative) MTCC 724, Bacillus subtilis MTCC 441, Staphylococcus aureus MTCC 737, Pseudomonas aerugenosa MTCC 424, and Salmonella typhimurium MTCC 3224. A new flavanone glycoside possesses potent anti-bacterial activity so it can be utilized as a potent source of antibacterial agents for food and pharmaceutical interest. [ABSTRACT FROM AUTHOR]

Flavonoids-enriched tissues of citrus such as peel, immature fruit and flower are consumed as culinary seasonings, tea ingredients in China for centuries. This HPLC quantitative study on the five citrus flavonoids, naringin, hesperidin, neohesperidin, sinensetin and nobiletin on a wide range of Chinese citrus fruits and several Traditional Chinese Medicinal food ingredients in East China, revealed a great diversity in flavonoid composition. Huyou peel (C. paradisi cv. Changshanhuyou)was found to be the best naringin (3.25%) and neohesperidin (2.76%) source; C. aurantium, a major ingredient of several citrus-related TCM, is also a suitable source of naringin and neohesperidin, and a good juice source for flavanone glycosides; the peel of Wenzhoumiju (C. unshiu) is one of the richest local species in hesperidin (up to 6.25%); Zaoju (C. subcompressa) has the highest content of nobiletin (0.59%), a polymethoxylated flavone. LC-ES-MS analysis of Zanthoxylum genus for flavonoids revealed for the first time the presence of significant amounts (0.74%) of hesperidin in the root of Liangmianzhen (Z. nitidum (Roxb.) DC), a relative of Sichuan pepper, which is a spice widely used in China. [ABSTRACT FROM AUTHOR]

Feline calicivirus is one of the surrogate viruses of human norovirus. This study aimed to identify virucidal compounds, chemical constituents of plants from the genus Dracocephalum , which are rich in flavonoids and phenylpropanoid oligomers. Four undescribed compounds, including a flavanone glucoside, two stilbenoid glycosides, and a phenylpropanoid amide glycoside, as well as 17 known compounds, were isolated from the Mongolian plants Dracocephalum fruticulosum Stephan ex Willd., and D. nutans L. belonging to the family Lamiaceae. The structures of the compounds were determined based on NMR, MS, and electronic CD spectroscopic data. In addition to these 21 compounds, 15 previously reported compounds from D. foetidum Bunge in C.F. von Ledebour were included, and a total of 36 compounds were evaluated for their virucidal activities against feline calicivirus. Some of the flavanone glycosides and phenylpropanoid oligomers showed virucidal activities, and their structural features are discussed. The findings suggest that isosakuranetin glycosides and phenylpropanoid oligomers may have the potential for norovirus inactivation. [Display omitted] • Four undescribed compounds were isolated from Dracocephalum spp. • Absolute configurations of the isolated undescribed compounds were determined. • Flavanone glycosides showed anti-Feline calicivirus activities. • Phenylpropanoid oligomers showed antivirus activities against Feline calicivirus. [ABSTRACT FROM AUTHOR]