1. Leucocyte energy metabolism. V. Glycolytic and hexose monophosphate shunt enzymes in leucocytes from adults and newborn infants.
- Author
-
Frei J, Prod'hom LS, and Fornerod-Brandenberger M
- Subjects
- Adult, Female, Fructose-Bisphosphate Aldolase blood, Glucose-6-Phosphate Isomerase blood, Glucosephosphate Dehydrogenase blood, Glyceraldehyde-3-Phosphate Dehydrogenases blood, Hexokinase blood, Humans, L-Lactate Dehydrogenase blood, Male, Phosphofructokinase-1 blood, Phosphogluconate Dehydrogenase blood, Phosphoglycerate Kinase blood, Phosphoglycerate Mutase blood, Phosphopyruvate Hydratase blood, Pyruvate Kinase blood, Triose-Phosphate Isomerase blood, Glycolysis, Hexosephosphates metabolism, Infant, Newborn, Leukocytes enzymology
- Abstract
The activities of ATP-consuming and ATP-producing steps of the Embden-Meyerhof pathway, as well as other glycolytic enzymes (phosphoglucomutase and enolase) and glucose-6-phosphate dehydrogenase are lower in leucocytes from cord blood than in white cells from adults. These results are related to previous observations (reduced anaerobic glycolysis and nitroblue tetrazolium-test in leucocytes from newborn infants) and discussed in connection with the fact that newborn infants are more susceptible to infections than normal adults.
- Published
- 1975