1. Glial Excitatory Amino Acid Transporters and Glucose Incorporation
- Author
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Germán Fernando, Gutiérrez Aguilar, Ivan, Alquisiras-Burgos, Mónica, Espinoza-Rojo, and Penélope, Aguilera
- Subjects
Neurons ,Glutamate Plasma Membrane Transport Proteins ,Glucose ,Astrocytes ,Glucose Transport Proteins, Facilitative ,Animals ,Brain ,Glutamic Acid ,Humans - Abstract
Excitatory amino acid transporters (EAATs) expressed in astrocytes remove the glutamate released by neurons in and around the synaptic cleft. In this manner, astrocytes preserve the signaling functions mediated by glutamate on synapses and prevent excitotoxicity. Additionally, EAAT activation stimulates glucose utilization in astrocytes, linking neuronal activity with astrocyte metabolism. In this chapter, we briefly review the characteristics of the EAATs and the glucose transporters (GLUTs) expressed in the brain. Thereafter, we focus on the effect of EAATs activation and its association with glucose utilization in astrocytes, specifically addressing the role played by Na
- Published
- 2017