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10 results on '"Improta L"'

2. Effects of prostaglandin E1 and prostaglandin F2alpha on insulin and glucagon plasma levels during the intravenous glucose tolerance test in man.

Author

Giugliano D, Torella R, Improta L, and D'Onofrio F

Subjects
Adult, Blood Glucose metabolism, Glucose Tolerance Test, Humans, Kinetics, Glucagon blood, Insulin blood, Prostaglandins E, Prostaglandins F
Abstract

The influence of prostaglandin E1 and prostaglandin F2alpha on circulating concentrations of insulin and glucagon during the intravenous glucose tolerance test has been studied in normal man. Insulin responses to glucose during PGE1 infusion (0.2 microgram/Kg/min) were significantly lower than in control infusions (p less than 0.001 at 2, 5, 10 and 15 min). Moreover, PGE1 caused a clear elevation of basal glucagon (p less than 0.02). PGF2alpha, at the two doses used (0.2 and 0.5 microgram/Kg/min), had no effect on basal glucose, insulin and glucagon levels, nor upon glucose-induced insulin secretion. Neither prostaglandin affected the glucose-induced inhibition of pancreatic alpha-cells. There is thus some evidence that PGs of E series may play some role in modulating the secretion of human pancreatic beta-cells.

Published
1978

4. Effects of metformin on plasma glucose, insulin, FFA, glucagon, growth hormone and cortisol responses to oral glucose in subjects with chemical diabetes.

Author

Giugliano D, Torella R, Improta L, and Scognamiglio G

Subjects
Adult, Clinical Trials as Topic, Female, Glucose Tolerance Test, Humans, Hypoglycemia blood, Male, Middle Aged, Blood Glucose metabolism, Diabetes Mellitus drug therapy, Fatty Acids, Nonesterified blood, Glucagon blood, Growth Hormone blood, Hydrocortisone blood, Insulin blood, Metformin therapeutic use
Published
1979

5. [Acetylsalicylic acid and hormonal response in insulin induced hypoglycemia].

Author

Torella R, Improta L, Giugliano D, and Tirelli A

Subjects
Adult, Humans, Hypoglycemia chemically induced, Insulin, Aspirin, Blood Glucose metabolism, Glucagon blood, Growth Hormone blood, Hypoglycemia metabolism
Abstract

The influence of a short-term treatment with acetylsalicylic acid (ASA 3,2 g/daily), an inhibitor of endogenous prostaglandin synthesis, on plasma glucose, glucagon and growth hormone responses to insulin-induced hypoglycemia, has been investigated in seven subjects. ASA caused a slight but significant reduction in basal glucose levels, but did not alter the pattern of glucagon and growth hormone secretion following hypoglycemia. On the basis of these results, it is hypothesized that endogenous prostaglandins are not implicated in the response of pancreatic alfa-cell to hypoglycemia.

Published
1979

6. Effects of metformin on plasma glucose, insulin, FFA, glucagon, growth hormone and cortisol responses to oral glucose in subjects with chemical diabetes

Author

Dario Giugliano, Torella, R., Improta, L., Scognamiglio, G., Giugliano, Dario, Torella, R, Improta, L, and Scognamiglio, G.

Subjects
Adult, Blood Glucose, Male, Clinical Trials as Topic, Hydrocortisone, Fatty Acids, Nonesterified, Glucose Tolerance Test, Middle Aged, Glucagon, Hypoglycemia, Metformin, Growth Hormone, Diabetes Mellitus, Humans, Insulin, Female
Published
1979

8. Glucose utilization from dialysate in patients on continuous ambulatory peritoneal dialysis (CAPD)

Author

Santo, N. G., Capodicasa, G., Senatore, R., Cicchetti, T., Cirillo, D., Damiano, M., Torella, R., Dario Giugliano, Improta, L., Giordano, C., DE SANTO, Ng, Capodicasa, G, Senatore, R, Cicchetti, T, Cirillo, D, Damiano, M, Torella, R, Giugliano, Dario, Improta, L, and Giordano, C.

Subjects
Adult, Blood Glucose, Male, Middle Aged, Glucagon, Solutions, Glucose, Ambulatory Care, Dietary Carbohydrates, Humans, Insulin, Female, Peritoneal Dialysis, Uremia

9. The effects of salbutamol on some metabolic and endocrine patterns of diabetic subjects

Author

Michele Varricchio, L Improta, Roberto Torella, F. Grandillo, Dario Giugliano, Torella, R, Grandillo, F, Giugliano, Dario, Improta, L, and Varricchio, M.

Subjects
Blood Glucose, Male, Drug, medicine.medical_specialty, media_common.quotation_subject, medicine.medical_treatment, Hydroxybutyrates, Fatty Acids, Nonesterified, Pharmacology, Diabetes mellitus, Internal medicine, Diabetes Mellitus, Humans, Insulin, Medicine, Endocrine system, Albuterol, Aged, media_common, business.industry, Middle Aged, Glucagon, medicine.disease, Plasma glucagon, Hormones, Constant rate, Endocrinology, Salbutamol, Female, business, Hormone, medicine.drug
Abstract

Summary The aim of this study was to investigate the effect of intravenous salbutamol on some metabolic and hormonal parameters in both normal and diabetic subjects. For this purpose, three insulin-dependent diabetics, six non insulin-dependent diabetics and eight normal subjects were infused with salbutamol at the constant rate of either 4.2 μg/min or 8.4 μg/min. Plasma glucose, free fatty acids, hydroxybutyrate and insulin (when present) levels rose significantly during salbutamol administration, whereas no consistent changes in plasma glucagon occurred. These results suggest caution in the use of this drug in human diabetes.

Published
1980

10. Effects of prostaglandin E1 and prostaglandin F2alpha on insulin and glucagon plasma levels during the intravenous glucose tolerance test in man

Author

D, Giugliano, R, Torella, L, Improta, F, D'Onofrio, Giugliano, Dario, Torella, R, Improta, L, and D'Onofrio, F.

Subjects
Adult, Blood Glucose, Kinetics, Prostaglandins E, Prostaglandins F, Humans, Insulin, Glucose Tolerance Test, Glucagon
Abstract

The influence of prostaglandin E1 and prostaglandin F2alpha on circulating concentrations of insulin and glucagon during the intravenous glucose tolerance test has been studied in normal man. Insulin responses to glucose during PGE1 infusion (0.2 microgram/Kg/min) were significantly lower than in control infusions (p less than 0.001 at 2, 5, 10 and 15 min). Moreover, PGE1 caused a clear elevation of basal glucagon (p less than 0.02). PGF2alpha, at the two doses used (0.2 and 0.5 microgram/Kg/min), had no effect on basal glucose, insulin and glucagon levels, nor upon glucose-induced insulin secretion. Neither prostaglandin affected the glucose-induced inhibition of pancreatic alpha-cells. There is thus some evidence that PGs of E series may play some role in modulating the secretion of human pancreatic beta-cells.

Published
1978

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