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1. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

Author

Roth, Gregory A, Johnson, Catherine, Abajobir, Amanuel, Abd-Allah, Foad, Abera, Semaw Ferede, Abyu, Gebre, Ahmed, Muktar, Aksut, Baran, Alam, Tahiya, Alam, Khurshid, Alla, François, Alvis-Guzman, Nelson, Amrock, Stephen, Ansari, Hossein, Ärnlöv, Johan, Asayesh, Hamid, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Awasthi, Ashish, Banerjee, Amitava, Barac, Aleksandra, Bärnighausen, Till, Barregard, Lars, Bedi, Neeraj, Ketema, Ezra Belay, Bennett, Derrick, Berhe, Gebremedhin, Bhutta, Zulfiqar, Bitew, Shimelash, Carapetis, Jonathan, Carrero, Juan Jesus, Malta, Deborah Carvalho, Castañeda-Orjuela, Carlos Andres, Castillo-Rivas, Jacqueline, Catalá-López, Ferrán, Choi, Jee-Young, Christensen, Hanne, Cirillo, Massimo, Cooper, Leslie, Criqui, Michael, Cundiff, David, Damasceno, Albertino, Dandona, Lalit, Dandona, Rakhi, Davletov, Kairat, Dharmaratne, Samath, Dorairaj, Prabhakaran, Dubey, Manisha, Ehrenkranz, Rebecca, Zaki, Maysaa El Sayed, Faraon, Emerito Jose A, Esteghamati, Alireza, Farid, Talha, Farvid, Maryam, Feigin, Valery, Ding, Eric L, Fowkes, Gerry, Gebrehiwot, Tsegaye, Gillum, Richard, Gold, Audra, Gona, Philimon, Gupta, Rajeev, Habtewold, Tesfa Dejenie, Hafezi-Nejad, Nima, Hailu, Tesfaye, Hailu, Gessessew Bugssa, Hankey, Graeme, Hassen, Hamid Yimam, Abate, Kalkidan Hassen, Havmoeller, Rasmus, Hay, Simon I, Horino, Masako, Hotez, Peter J, Jacobsen, Kathryn, James, Spencer, Javanbakht, Mehdi, Jeemon, Panniyammakal, John, Denny, Jonas, Jost, Kalkonde, Yogeshwar, Karimkhani, Chante, Kasaeian, Amir, Khader, Yousef, Khan, Abdur, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah T, Khubchandani, Jagdish, Kim, Daniel, Kolte, Dhaval, Kosen, Soewarta, Krohn, Kristopher J, Kumar, G Anil, Kwan, Gene F, Lal, Dharmesh Kumar, Larsson, Anders, Linn, Shai, Lopez, Alan, Lotufo, Paulo A, and Razek, Hassan Magdy Abd El

Subjects
Prevention, Cardiovascular, Burden of Illness, Heart Disease, Aging, Aetiology, 2.4 Surveillance and distribution, Good Health and Well Being, Adult, Aged, Cardiovascular Diseases, Cause of Death, Female, Global Health, Humans, Life Expectancy, Male, Middle Aged, Morbidity, Prevalence, Prospective Studies, Retrospective Studies, Risk Assessment, Risk Factors, Sex Distribution, Survival Rate, Young Adult, cause of death, epidemiology, global health, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundThe burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world.ObjectivesThe GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden.MethodsCVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility.ResultsIn 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75.ConclusionsCVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.

Published
2017

2. Diabetes mellitus and chronic kidney disease in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study

Author

Mokdad, Ali H, Moradi-Lakeh, Maziar, El Bcheraoui, Charbel, Khalil, Ibrahim, Charara, Raghid, Afshin, Ashkan, Wang, Haidong, Collison, Michael, Krohn, Kristopher J, Chew, Adrienne, Daoud, Farah, Blosser, Christopher D, Cornaby, Leslie, Foreman, Kyle J, Kassebaum, Nicholas J, Kemmer, Laura, Kutz, Michael, Liu, Patrick, Zipkin, Ben, Arnlov, Johan, Abate, Kalkidan Hassen, Ahmadi, Alireza, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Al-Aly, Ziyad, Alam, Khurshid, Alasfoor, Deena, Ali, Raghib, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Al-Raddadi, Rajaa, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amini, Erfan, Anber, Nahla, Anwari, Palwasha, Asgedom, Solomon Weldegebreal, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Awasthi, Ashish, Azzopardi, Peter, Baernighausen, Till, Bacha, Umar, Barac, Aleksandra, Bazargan-Hejazi, Shahrzad, Drew, Charles R, Geffen, David, Bedi, Neeraj, Berhe, Derbew Fikadu, Beyene, Addisu Shunu, Bhutta, Zulfiqar A, Bikbov, Boris, Birhanu, Mulugeta M, Butt, Zahid A, Cahuana-Hurtado, Lucero, Carpenter, David O, Carrero, Juan Jesus, Choi, Jee-Young Jasmine J, Danawi, Hadi, Dharmaratne, Samath D, Ding, Eric L, Djalalinia, Shirin, Doyle, Kerrie E, Ebrahimi, Hedyeh, Endries, Aman Yesuf, Esteghamati, Alireza, Farvid, Maryam S, Fereshtehnejad, Seyed-Mohammad, Feyissa, Tesfaye Regassa, Fischer, Florian, Gebrehiwot, Tsegaye Tewelde, Gona, Philimon N, Gopalani, Sameer Vali, Gyawali, Bishal, Hafezi-Nejad, Nima, Hamadeh, Randah Ribhi, Hamidi, Samer, Horino, Masako, Hsairi, Mohamed, Jakovljevic, Mihajlo B, Jimenez-Corona, Aida, John, Denny, Jonas, Jost B, Kasaeian, Amir, Kengne, Andre Pascal, Ketema, Ezra Belay, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Kim, Daniel, Kim, Yun Jin, Kinfu, Yohannes, Kissimova-Skarbek, Katarzyna A, Koyanagi, Ai, Larson, Heidi J, Larsson, Anders, Li, Yongmei, Lotufo, Paulo A, Lunevicius, Raimundas, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Mazidi, Mohsen, Memish, Ziad A, Mendoza, Walter, Mengistie, Mubarek Abera, Mensah, George A, Mezgebe, Haftay Berhane, Miller, Ted R, Mohammed, Muktar Sano Kedir, Mohammed, Shafiu, Mueller, Ulrich O, Nagel, Gabriele, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nong, Vuong Minh, Noubiap, Jean Jacques N, Ogbo, Felix Akpojene, Ortiz, Alberto, Ota, Erika, Patel, Tejas, Pearson-Stuttard, Jonathan, Perico, Norberto, Petzold, Max, Pishgar, Farhad, Pourmalek, Farshad, Qorbani, Mostafa, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rana, Saleem M, Rawaf, David Laith, Rawaf, Salman, Remuzzi, Giuseppe, Renzaho, Andre MNN, Rezaei, Satar, Roshandel, Gholamreza, Bacher, Dietrich Rothen, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sahraian, Mohammad Ali, Salamati, Payman, Samy, Abdallah M, Sanabria, Juan Ramon, Dolores Sanchez-Nino, Maria, Milicevic, Milena M Santric, Sartorius, Benn, Sepanlou, Sadaf G, Shaikh, Masood Ali, Santos Silva, Diego Augusto, Alves Silveira, Dayane Gabriele, Sobaih, Badr HA, Abdulkader, Rizwan Suliankatchi, Tabares-Seisdedos, Rafael, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Topor-Madry, Roman, Tran, Bach Xuan, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, van Boven, Job FM, Wakayo, Tolassa, Werdecker, Andrea, Workicho, Abdulhalik, Yaghoubi, Mohsen, Yano, Yuichiro, Yaseri, Mehdi, Yonemoto, Naohiro, Younis, Mustafa Z, Zhang, Anthony Lin, Jumaan, Aisha O, Vos, Theo, Naghavi, Mohsen, Hay, Simon I, Murray, Christopher JL, Reg, GBD 2015 Eastern Mediterranean, Moradi-Lakeh, M, El Bcheraoui, C, Khalil, I, Ahmed, MB, Mokdad, AH, GBD 2015 Eastern Mediterranean Region Diabetes, Chronic Kidney Disease Collaborators, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), and Value, Affordability and Sustainability (VALUE)

Subjects
Diabetes, Chronic kidney disease, Burden of disease, Eastern Mediterranean Region, Health (social science), Mediterranean Region/epidemiology, Psychological intervention, Eastern Mediterranean region, Eastern, 030204 cardiovascular system & hematology, burden of disease, Global Health, Global Burden of Disease, 0302 clinical medicine, SAUDI-ARABIA, WORLD, Health care, Global health, Prevalence, 030212 general & internal medicine, Renal Insufficiency, Chronic/economics, diabetes, Mediterranean Region, Public Health, Global Health, Social Medicine and Epidemiology, MORTALIDADE, Diabetes Complications/economics, 1117 Public Health And Health Services, Original Article, Public Health, Quality-Adjusted Life Years, INTERVENTIONS, KINGDOM, medicine.medical_specialty, Middle East/epidemiology, Global Burden of Disease/statistics & numerical data, Diabetes Complications, Middle East, 03 medical and health sciences, DIETARY, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, Renal Insufficiency, Chronic, Diabetes Mellitus/economics, Intensive care medicine, METAANALYSIS, business.industry, MORTALITY, Klinisk medicin, Public Health, Environmental and Occupational Health, medicine.disease, PREVENTION, Quality-adjusted life year, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Eastern mediterranean, HEALTH-CARE, RISK-FACTORS, Physical therapy, Clinical Medicine, business, chronic kidney disease, Kidney disease
Abstract

Objectives We used findings from the Global Burden of Disease 2015 study to update our previous publication on the burden of diabetes and chronic kidney disease due to diabetes (CKD-DM) during 1990–2015. Methods We extracted GBD 2015 estimates for prevalence, mortality, and disability-adjusted life years (DALYs) of diabetes (including burden of low vision due to diabetes, neuropathy, and amputations and CKD-DM for 22 countries of the EMR from the GBD visualization tools. Results In 2015, 135,230 (95% UI 123,034–148,184) individuals died from diabetes and 16,470 (95% UI 13,977–18,961) from CKD-DM, 216 and 179% increases, respectively, compared to 1990. The total number of people with diabetes was 42.3 million (95% UI 38.6–46.4 million) in 2015. DALY rates of diabetes in 2015 were significantly higher than the expected rates based on Socio-demographic Index (SDI). Conclusions Our study showed a large and increasing burden of diabetes in the region. There is an urgency in dealing with diabetes and its consequences, and these efforts should be at the forefront of health prevention and promotion. Electronic supplementary material The online version of this article (doi:10.1007/s00038-017-1014-1) contains supplementary material, which is available to authorized users.

Published
2018

3. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

Author

Roth, Gregory A., Johnson, Catherine, Abajobir, Amanuel, Abd-Allah, Foad, Abera, Semaw Ferede, Abyu, Gebre, Ahmed, Muktar, Aksut, Baran, Alam, Tahiya, Alam, Khurshid, Alla, Francois, Alvis-Guzman, Nelson, Amrock, Stephen, Ansari, Hossein, Arnlov, Johan, Asayesh, Hamid, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Awasthi, Ashish, Banerjee, Amitava, Barac, Aleksandra, Barnighausen, Till, Barregard, Lars, Bedi, Neeraj, Ketema, Ezra Belay, Bennett, Derrick, Berhe, Gebremedhin, Bhutta, Zulfiqar, Bitew, Shimelash, Carapetis, Jonathan, Carrero, Juan Jesus, Malta, Deborah Carvalho, Andres Castaneda-Orjuela, Carlos, Castillo-Rivas, Jacqueline, Catala-Lopez, Ferran, Choi, Jee-Young, Christensen, Hanne, Cirillo, Massimo, Cooper, Leslie, Criqui, Michael, Cundiff, David, Damasceno, Albertino, Dandona, Lalit, Dandona, Rakhi, Davletov, Kairat, Dharmaratne, Samath, Dorairaj, Prabhakaran, Dubey, Manisha, Ehrenkranz, Rebecca, Zaki, Maysaa El Sayed, Faraon, Emerito Jose A., Esteghamati, Alireza, Farid, Talha, Farvid, Maryam, Feigin, Valery, Ding, Eric L., Fowkes, Gerry, Gebrehiwot, Tsegaye, Gillum, Richard, Gold, Audra, Gona, Philimon, Gupta, Rajeev, Habtewold, Tesfa Dejenie, Hafezi-Nejad, Nima, Hailu, Tesfaye, Hailu, Gessessew Bugssa, Hankey, Graeme, Hassen, Hamid Yimam, Abate, Kalkidan Hassen, Havmoeller, Rasmus, Hay, Simon I., Horino, Masako, Hotez, Peter J., Jacobsen, Kathryn, James, Spencer, Javanbakht, Mehdi, Jeemon, Panniyammakal, John, Denny, Jonas, Jost, Kalkonde, Yogeshwar, Karimkhani, Chante, Kasaeian, Amir, Khader, Yousef, Khan, Abdur, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah T., Khubchandani, Jagdish, Kim, Daniel, Kolte, Dhaval, Kosen, Soewarta, Krohn, Kristopher J., Kumar, G. Anil, Kwan, Gene F., Lal, Dharmesh Kumar, Larsson, Anders, Linn, Shai, Lopez, Alan, Lotufo, Paulo A., Abd El Razek, Hassan Magdy, Malekzadeh, Reza, Mazidi, Mohsen, Meier, Toni, Meles, Kidanu Gebremariam, Mensah, George, Meretoja, Atte, Mezgebe, Haftay, Miller, Ted, Mirrakhimov, Erkin, Mohammed, Shafiu, Moran, Andrew E., Musa, Kamarul Imran, Narula, Jagat, Neal, Bruce, Ngalesoni, Frida, Grant Nguyen, Obermeyer, Carla Makhlouf, Owolabi, Mayowa, Patton, George, Pedro, Joao, Qato, Dima, Qorbani, Mostafa, Rahimi, Kazem, Rai, Rajesh Kumar, Rawaf, Salman, Ribeiro, Antonio, Safiri, Saeid, Salomon, Joshua A., Santos, Itamar, Milicevic, Milena Santric, Sartorius, Benn, Schutte, Aletta, Sepanlou, Sadaf, Shaikh, Masood Ali, Shin, Min-Jeong, Shishehbor, Mehdi, Shore, Hirbo, Santos Silva, Diego Augusto, Sobngwi, Eugene, Stranges, Saverio, Swaminathan, Soumya, Tabares-Seisdedos, Rafael, Atnafu, Niguse Tadele, Tesfay, Fisaha, Thakur, J. S., Thrift, Amanda, Topor-Madry, Roman, Truelsen, Thomas, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Uthman, Olalekan, Vasankari, Tommi, Vlassov, Vasiliy, Vollset, Stein Emil, Wakayo, Tolassa, Watkins, David, Weintraub, Robert, Werdecker, Andrea, Westerman, Ronny, Wiysonge, Charles Shey, Wolfe, Charles, Workicho, Abdulhalik, Xu, Gelin, Yano, Yuichiro, Yip, Paul, Yonemoto, Naohiro, Younis, Mustafa, Yu, Chuanhua, Vos, Theo, Naghavi, Mohsen, Murray, Christopher, Roth, Gregory, Johnson, Catherine, Abajobir, Amanuel, Abd-Allah, Foad, Semaw, Ferede Abera, Gebre, Abyu, Muktar, Ahmed, Baran, Aksut, Tahiya, Alam, Khurshid, Alam, François, Alla, Nelson, Alvis-Guzman, Stephen, Amrock, Hossein, Ansari, Johan, Ärnlöv, Hamid, Asayesh, Tesfay, Mehari Atey, Leticia, Avila-Burgo, Ashish, Awasthi, Amitava, Banerjee, Aleksandra, Barac, Till, Bärnighausen, Lars, Barregard, Neeraj, Bedi, Ezra, Belay Ketema, Derrick, Bennett, Gebremedhin, Berhe, Zulfiqar, Bhutta, Shimelash, Bitew, Jonathan, Carapeti, Juan, Jesus Carrero, Deborah, Carvalho Malta, Carlos, Andres Castañeda-Orjuela, Jacqueline, Castillo-Riva, Ferrán, Catalá-López, Jee-Young, Choi, Hanne, Christensen, Cirillo, Massimo, Leslie, Cooper, Michael, Criqui, David, Cundiff, Albertino, Damasceno, Lalit, Dandona, Rakhi, Dandona, Kairat, Davletov, Samath, Dharmaratne, Prabhakaran, Dorairaj, Manisha, Dubey, Rebecca, Ehrenkranz, Maysaa, El Sayed Zaki, Emerito, Jose A. Faraon, Alireza, Esteghamati, Talha, Farid, Maryam, Farvid, Valery, Feigin, Eric, L. Ding, Gerry, Fowke, Tsegaye, Gebrehiwot, Richard, Gillum, Audra, Gold, Philimon, Gona, Rajeev, Gupta, Tesfa, Dejenie Habtewold, Nima, Hafezi-Nejad, Tesfaye, Hailu, Gessessew, Bugssa Hailu, Graeme, Hankey, Hamid, Yimam Hassen, Kalkidan, Hassen Abate, Rasmus, Havmoeller, Simon, Hay, Masako, Horino, Peter, Hotez, Kathryn, Jacobsen, Spencer, Jame, Mehdi, Javanbakht, Panniyammakal, Jeemon, Denny, John, Jost, Jona, Yogeshwar, Kalkonde, Chante, Karimkhani, Amir, Kasaeian, Yousef, Khader, Abdur, Khan, Young-Ho, Khang, Sahil, Khera, Abdullah, Khoja, Jagdish, Khubchandani, Daniel, Kim, Dhaval, Kolte, Soewarta, Kosen, Kristopher, Krohn, Anil, Kumar, Gene, Kwan, Dharmesh, Kumar Lal, Anders, Larsson, Shai, Linn, Alan, Lopez, Paulo, Lotufo, Hassan, Magdy, Abd El, Razek, Reza, Malekzadeh, Mohsen, Mazidi, Toni, Meier, Kidanu, Gebremariam Mele, George, Mensah, Atte, Meretoja, Haftay, Mezgebe, Ted, Miller, Erkin, Mirrakhimov, Shafiu, Mohammed, Andrew, Moran, Kamarul, Imran Musa, Jagat, Narula, Bruce, Neal, Frida, Ngalesoni, Grant, Nguyen, Carla, Makhlouf Obermeyer, Mayowa, Owolabi, George, Patton, João, Pedro, Dima, Qato, Mostafa, Qorbani, Kazem, Rahimi, Rajesh, Kumar Rai, Salman, Rawaf, Antônio, Ribeiro, Saeid, Safiri, Joshua, Salomon, Itamar, Santo, Milena, Santric Milicevic, Benn, Sartoriu, Aletta, Schutte, Sadaf, Sepanlou, Masood, Ali Shaikh, Min-Jeong, Shin, Mehdi, Shishehbor, Hirbo, Shore, Diego, Augusto Santos Silva, Eugene, Sobngwi, Saverio, Strange, Soumya, Swaminathan, Rafael, Tabarés-Seisdedo, Niguse, Tadele Atnafu, Fisaha, Tesfay Thakur, Amanda, Thrift, Roman, Topor-Madry, Thomas, Truelsen, Stefanos, Tyrovola, Kingsley, Nnanna Ukwaja, Olalekan, Uthman, Tommi, Vasankari, Vasiliy, Vlassov, Stein, Emil Vollset, Tolassa, Wakayo, David, Watkin, Robert, Weintraub, Andrea, Werdecker, Ronny, Westerman, Charles, Shey Wiysonge, Charles, Wolfe, Abdulhalik, Workicho, Gelin, Xu, Yuichiro, Yano, Paul, Yip, Naohiro, Yonemoto, Mustafa, Youni, Chuanhua, Yu, Theo, Vo, Mohsen, Naghavi, and Christopher, Murray.

Subjects
Adult, Male, Cardiac & Cardiovascular Systems, DEATHS, global health, Risk Assessment, 1102 Cardiovascular Medicine And Haematology, LOW-INCOME COUNTRIES, Young Adult, cause of death, Life Expectancy, Risk Factors, AMERICAN-HEART-ASSOCIATION, SYSTEMATIC ANALYSIS, Prevalence, Humans, Prospective Studies, Sex Distribution, Aged, Retrospective Studies, Science & Technology, HYPERTENSION, PERIPHERAL ARTERIAL-DISEASE, CAUSE-SPECIFIC MORTALITY, Middle Aged, Global Burden of Disease - Cardiovascular Disease, Survival Rate, 1117 Public Health And Health Services, Cardiovascular System & Hematology, Cardiovascular Diseases, DISABILITY WEIGHTS, Cardiovascular System & Cardiology, RISK-FACTORS, Female, epidemiology, Morbidity, Life Sciences & Biomedicine
Abstract

Background The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. Objectives The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. Methods CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Results In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. Conclusions CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.

Published
2017

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