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Your search keyword '"Haagsma, Juanita A"' showing total 39 results
Start Over Author "Haagsma, Juanita A" Topic global burden of disease
39 results on '"Haagsma, Juanita A"'

1. The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019.

Author

Santos JV, Padron-Monedero A, Bikbov B, Grad DA, Plass D, Mechili EA, Gazzelloni F, Fischer F, Sulo G, Ngwa CH, Noguer-Zambrano I, Peñalvo JL, Haagsma JA, Kissimova-Skarbek K, Monasta L, Ghith N, Sarmiento-Suarez R, Hrzic R, Haneef R, O'Caoimh R, Cuschieri S, Mondello S, Kabir Z, Freitas A, and Devleesschauwer B

Subjects
Humans, Male, Health Status, Female, Cost of Illness, European Union statistics & numerical data, Global Burden of Disease trends, Life Expectancy trends, Disability-Adjusted Life Years trends
Abstract

Background: The European Union (EU) faces many health-related challenges. Burden of diseases information and the resulting trends over time are essential for health planning. This paper reports estimates of disease burden in the EU and individual 27 EU countries in 2019, and compares them with those in 2010., Methods: We used the Global Burden of Disease 2019 study estimates and 95% uncertainty intervals for the whole EU and each country to evaluate age-standardised death, years of life lost (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) rates for Level 2 causes, as well as life expectancy and healthy life expectancy (HALE)., Results: In 2019, the age-standardised death and DALY rates in the EU were 465.8 deaths and 20,251.0 DALYs per 100,000 inhabitants, respectively. Between 2010 and 2019, there were significant decreases in age-standardised death and YLL rates across EU countries. However, YLD rates remained mainly unchanged. The largest decreases in age-standardised DALY rates were observed for "HIV/AIDS and sexually transmitted diseases" and "transport injuries" (each -19%). "Diabetes and kidney diseases" showed a significant increase for age-standardised DALY rates across the EU (3.5%). In addition, "mental disorders" showed an increasing age-standardised YLL rate (14.5%)., Conclusions: There was a clear trend towards improvement in the overall health status of the EU but with differences between countries. EU health policymakers need to address the burden of diseases, paying specific attention to causes such as mental disorders. There are many opportunities for mutual learning among otherwise similar countries with different patterns of disease., (© 2024. The Author(s).)

Published
2024
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2. Epidemiology of injuries from fire, heat and hot substances: global, regional and national morbidity and mortality estimates from the Global Burden of Disease 2017 study.

Author

James SL, Lucchesi LR, Bisignano C, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Henry NJ, McCracken D, Roberts NLS, Sylte DO, Ahmadi A, Ahmed MB, Alahdab F, Alipour V, Andualem Z, Antonio CAT, Arabloo J, Badiye AD, Bagherzadeh M, Banstola A, Bärnighausen TW, Barzegar A, Bayati M, Bhaumik S, Bijani A, Bukhman G, Carvalho F, Crowe CS, Dalal K, Daryani A, Nasab MD, Do HT, Do HP, Endries AY, Fernandes E, Filip I, Fischer F, Fukumoto T, Gebremedhin KBB, Gebremeskel GG, Gilani SA, Haagsma JA, Hamidi S, Hostiuc S, Househ M, Igumbor EU, Ilesanmi OS, Irvani SSN, Jayatilleke AU, Kahsay A, Kapoor N, Kasaeian A, Khader YS, Khalil IA, Khan EA, Khazaee-Pool M, Kokubo Y, Lopez AD, Madadin M, Majdan M, Maled V, Malekzadeh R, Manafi N, Manafi A, Mangalam S, Massenburg BB, Meles HG, Menezes RG, Meretoja TJ, Miazgowski B, Miller TR, Mohammadian-Hafshejani A, Mohammadpourhodki R, Morrison SD, Negoi I, Nguyen TH, Nguyen SH, Nguyen CT, Nixon MR, Olagunju AT, Olagunju TO, Padubidri JR, Polinder S, Rabiee N, Rabiee M, Radfar A, Rahimi-Movaghar V, Rawaf S, Rawaf DL, Rezapour A, Rickard J, Roro EM, Roy N, Safari-Faramani R, Salamati P, Samy AM, Satpathy M, Sawhney M, Schwebel DC, Senthilkumaran S, Sepanlou SG, Shigematsu M, Soheili A, Stokes MA, Tohidinik HR, Tran BX, Valdez PR, Wijeratne T, Yisma E, Zaidi Z, Zamani M, Zhang ZJ, Hay SI, and Mokdad AH

Subjects
Global Health, Humans, Incidence, Morbidity, Prevalence, Quality-Adjusted Life Years, Global Burden of Disease, Hot Temperature, Wounds and Injuries mortality
Abstract

Background: Past research has shown how fires, heat and hot substances are important causes of health loss globally. Detailed estimates of the morbidity and mortality from these injuries could help drive preventative measures and improved access to care., Methods: We used the Global Burden of Disease 2017 framework to produce three main results. First, we produced results on incidence, prevalence, years lived with disability, deaths, years of life lost and disability-adjusted life years from 1990 to 2017 for 195 countries and territories. Second, we analysed these results to measure mortality-to-incidence ratios by location. Third, we reported the measures above in terms of the cause of fire, heat and hot substances and the types of bodily injuries that result., Results: Globally, there were 8 991 468 (7 481 218 to 10 740 897) new fire, heat and hot substance injuries in 2017 with 120 632 (101 630 to 129 383) deaths. At the global level, the age-standardised mortality caused by fire, heat and hot substances significantly declined from 1990 to 2017, but regionally there was variability in age-standardised incidence with some regions experiencing an increase (eg, Southern Latin America) and others experiencing a significant decrease (eg, High-income North America)., Conclusions: The incidence and mortality of injuries that result from fire, heat and hot substances affect every region of the world but are most concentrated in middle and lower income areas. More resources should be invested in measuring these injuries as well as in improving infrastructure, advancing safety measures and ensuring access to care., Competing Interests: Competing interests: Dr. Spencer James reports grants from Sanofi Pasteur, outside the submitted work. All other authors have nothing to disclose. Dr. Carl Abelardo T Antonio reports grants and personal fees from Johnson & Johnson (Philippines), Inc., outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

Published
2020
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3. Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study.

Author

James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, Roberts NLS, Sylte DO, Bertolacci GJ, Cunningham M, Henry NJ, LeGrand KE, Abdelalim A, Abdollahpour I, Abdulkader RS, Abedi A, Abegaz KH, Abosetugn AE, Abushouk AI, Adebayo OM, Adsuar JC, Advani SM, Agudelo-Botero M, Ahmad T, Ahmed MB, Ahmed R, Eddine Aichour MT, Alahdab F, Alanezi FM, Alema NM, Alemu BW, Alghnam SA, Ali BA, Ali S, Alinia C, Alipour V, Aljunid SM, Almasi-Hashiani A, Almasri NA, Altirkawi K, Abdeldayem Amer YS, Andrei CL, Ansari-Moghaddam A, T Antonio CA, Anvari D, Yaw Appiah SC, Arabloo J, Arab-Zozani M, Arefi Z, Aremu O, Ariani F, Arora A, Asaad M, Ayala Quintanilla BP, Ayano G, Ayanore MA, Azarian G, Badawi A, Badiye AD, Baig AA, Bairwa M, Bakhtiari A, Balachandran A, Banach M, Banerjee SK, Banik PC, Banstola A, Barker-Collo SL, Bärnighausen TW, Barzegar A, Bayati M, Bazargan-Hejazi S, Bedi N, Behzadifar M, Belete H, Bennett DA, Bensenor IM, Berhe K, Bhagavathula AS, Bhardwaj P, Bhat AG, Bhattacharyya K, Bhutta ZA, Bibi S, Bijani A, Boloor A, Borges G, Borschmann R, Borzì AM, Boufous S, Braithwaite D, Briko NI, Brugha T, Budhathoki SS, Car J, Cárdenas R, Carvalho F, Castaldelli-Maia JM, Castañeda-Orjuela CA, Castelpietra G, Catalá-López F, Cerin E, Chandan JS, Chapman JR, Chattu VK, Chattu SK, Chatziralli I, Chaudhary N, Cho DY, Choi JJ, Kabir Chowdhury MA, Christopher DJ, Chu DT, Cicuttini FM, Coelho JM, Costa VM, Dahlawi SMA, Daryani A, Dávila-Cervantes CA, Leo D, Demeke FM, Demoz GT, Demsie DG, Deribe K, Desai R, Nasab MD, Silva DDD, Dibaji Forooshani ZS, Do HT, Doyle KE, Driscoll TR, Dubljanin E, Adema BD, Eagan AW, Elemineh DA, El-Jaafary SI, El-Khatib Z, Ellingsen CL, Zaki MES, Eskandarieh S, Eyawo O, Faris PS, Faro A, Farzadfar F, Fereshtehnejad SM, Fernandes E, Ferrara P, Fischer F, Folayan MO, Fomenkov AA, Foroutan M, Francis JM, Franklin RC, Fukumoto T, Geberemariyam BS, Gebremariam H, Gebremedhin KB, Gebremeskel LG, Gebremeskel GG, Gebremichael B, Gedefaw GA, Geta B, Getenet AB, Ghafourifard M, Ghamari F, Gheshlagh RG, Gholamian A, Gilani SA, Gill TK, Goudarzian AH, Goulart AC, Grada A, Grivna M, Guimarães RA, Guo Y, Gupta G, Haagsma JA, Hall BJ, Hamadeh RR, Hamidi S, Handiso DW, Haro JM, Hasanzadeh A, Hassan S, Hassanipour S, Hassankhani H, Hassen HY, Havmoeller R, Hendrie D, Heydarpour F, Híjar M, Ho HC, Hoang CL, Hole MK, Holla R, Hossain N, Hosseinzadeh M, Hostiuc S, Hu G, Ibitoye SE, Ilesanmi OS, Inbaraj LR, Naghibi Irvani SS, Mofizul Islam M, Shariful Islam SM, Ivers RQ, Jahani MA, Jakovljevic M, Jalilian F, Jayaraman S, Jayatilleke AU, Jha RP, John-Akinola YO, Jonas JB, Jones KM, Joseph N, Joukar F, Jozwiak JJ, Jungari SB, Jürisson M, Kabir A, Kahsay A, Kalankesh LR, Kalhor R, Kamil TA, Kanchan T, Kapoor N, Karami M, Kasaeian A, Kassaye HG, Kavetskyy T, Kayode GA, Keiyoro PN, Kelbore AG, Khader YS, Khafaie MA, Khalid N, Khalil IA, Khalilov R, Khan M, Khan EA, Khan J, Khanna T, Khazaei S, Khazaie H, Khundkar R, Kiirithio DN, Kim YE, Kim YJ, Kim D, Kisa S, Kisa A, Komaki H, Kondlahalli SKM, Koolivand A, Korshunov VA, Koyanagi A, Kraemer MUG, Krishan K, Defo BK, Bicer BK, Kugbey N, Kumar N, Kumar M, Kumar V, Kumar N, Kumaresh G, Lami FH, Lansingh VC, Lasrado S, Latifi A, Lauriola P, Vecchia C, Leasher JL, Huey Lee SW, Li S, Liu X, Lopez AD, Lotufo PA, Lyons RA, Machado DB, Madadin M, Abd El Razek MM, Mahotra NB, Majdan M, Majeed A, Maled V, Malta DC, Manafi N, Manafi A, Manda AL, Manjunatha N, Mansour-Ghanaei F, Mansournia MA, Maravilla JC, Mason-Jones AJ, Masoumi SZ, Massenburg BB, Maulik PK, Mehndiratta MM, Melketsedik ZA, Memiah PTN, Mendoza W, Menezes RG, Mengesha MM, Meretoja TJ, Meretoja A, Merie HE, Mestrovic T, Miazgowski B, Miazgowski T, Miller TR, Mini GK, Mirica A, Mirrakhimov EM, Mirzaei-Alavijeh M, Mithra P, Moazen B, Moghadaszadeh M, Mohamadi E, Mohammad Y, Darwesh AM, Mohammadian-Hafshejani A, Mohammadpourhodki R, Mohammed S, Mohammed JA, Mohebi F, Mohseni Bandpei MA, Molokhia M, Monasta L, Moodley Y, Moradi M, Moradi G, Moradi-Lakeh M, Moradzadeh R, Morawska L, Velásquez IM, Morrison SD, Mossie TB, Muluneh AG, Musa KI, Mustafa G, Naderi M, Nagarajan AJ, Naik G, Naimzada MD, Najafi F, Nangia V, Nascimento BR, Naserbakht M, Nayak V, Nazari J, Ndwandwe DE, Negoi I, Ngunjiri JW, Nguyen TH, Nguyen CT, Nguyen DN, Thi Nguyen HL, Nikbakhsh R, Anggraini Ningrum DN, Nnaji CA, Ofori-Asenso R, Ogbo FA, Oghenetega OB, Oh IH, Olagunju AT, Olagunju TO, Bali AO, Onwujekwe OE, Orpana HM, Ota E, Otstavnov N, Otstavnov SS, P A M, Padubidri JR, Pakhale S, Pakshir K, Panda-Jonas S, Park EK, Patel SK, Pathak A, Pati S, Paulos K, Peden AE, Filipino Pepito VC, Pereira J, Phillips MR, Polibin RV, Polinder S, Pourmalek F, Pourshams A, Poustchi H, Prakash S, Angga Pribadi DR, Puri P, Syed ZQ, Rabiee N, Rabiee M, Radfar A, Rafay A, Rafiee A, Rafiei A, Rahim F, Rahimi S, Rahman MA, Rajabpour-Sanati A, Rajati F, Rakovac I, Rao SJ, Rashedi V, Rastogi P, Rathi P, Rawaf S, Rawal L, Rawassizadeh R, Renjith V, Resnikoff S, Rezapour A, Ribeiro AI, Rickard J, Rios González CM, Roever L, Ronfani L, Roshandel G, Saddik B, Safarpour H, Safdarian M, Mohammad Sajadi S, Salamati P, Rashad Salem MR, Salem H, Salz I, Samy AM, Sanabria J, Riera LS, Santric Milicevic MM, Sarker AR, Sarveazad A, Sathian B, Sawhney M, Sayyah M, Schwebel DC, Seedat S, Senthilkumaran S, Seyedmousavi S, Sha F, Shaahmadi F, Shahabi S, Shaikh MA, Shams-Beyranvand M, Sheikh A, Shigematsu M, Shin JI, Shiri R, Siabani S, Sigfusdottir ID, Singh JA, Singh PK, Sinha DN, Soheili A, Soriano JB, Sorrie MB, Soyiri IN, Stokes MA, Sufiyan MB, Sykes BL, Tabarés-Seisdedos R, Tabb KM, Taddele BW, Tefera YM, Tehrani-Banihashemi A, Tekulu GH, Tesema Tesema AK, Tesfay BE, Thapar R, Titova MV, Tlaye KG, Tohidinik HR, Topor-Madry R, Tran KB, Tran BX, Tripathy JP, Tsai AC, Tsatsakis A, Car LT, Ullah I, Ullah S, Unnikrishnan B, Upadhyay E, Uthman OA, Valdez PR, Vasankari TJ, Veisani Y, Venketasubramanian N, Violante FS, Vlassov V, Waheed Y, Wang YP, Wiangkham T, Wolde HF, Woldeyes DH, Wondmeneh TG, Wondmieneh AB, Wu AM, Wyper GMA, Yadav R, Yadollahpour A, Yano Y, Yaya S, Yazdi-Feyzabadi V, Ye P, Yip P, Yisma E, Yonemoto N, Yoon SJ, Youm Y, Younis MZ, Yousefi Z, Yu C, Yu Y, Moghadam TZ, Zaidi Z, Zaman SB, Zamani M, Zandian H, Zarei F, Zhang ZJ, Zhang Y, Ziapour A, Zodpey S, Dandona R, Dharmaratne SD, Hay SI, Mokdad AH, Pigott DM, Reiner RC, and Vos T

Subjects
Female, Humans, Incidence, Life Expectancy, Male, Morbidity, Quality-Adjusted Life Years, Global Burden of Disease, Global Health, Wounds and Injuries mortality
Abstract

Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria., Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced., Results: GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes., Conclusions: GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future., Competing Interests: Competing interests: Dr. James reports grants from Sanofi Pasteur, outside the submitted work. Dr. Driscoll reports grants from World Health Organisation, during the conduct of the study. Dr Shariful Islam is funded by a Fellowship from National Heart Foundation of Australia and Institute for Physical Activity and Nutrition, Deakin University. Dr. Ivers reports grants from National Health and Medical Research Council of Australia, during the conduct of the study. Dr. Jozwiak reports personal fees from TEVA, personal fees from ALAB, personal fees from BOEHRINGER INGELHEIM, personal fees from SYNEXUS, non-financial support from SERVIER, non-financial support from MICROLIFE, non-financial support from MEDICOVER, outside the submitted work. Walter Mendoza is currently Program Analyst Population and Development at the Peru Country Office of the United Nations Population Fund-UNFPA, which does not necessarily endorses this study. Dr. Rakovac reports grants from World Health Organization, during the conduct of the study. Dr. Sheikh reports grants from Health Data Research UK, outside the submitted work. Dr. Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio health, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Spherix, Practice Point communications, the National Institutes of Health and the American College of Rheumatology, personal fees from Speaker’s bureau of Simply Speaking. Dr. Singh owns stock options in Amarin pharmaceuticals and Viking pharmaceuticals. Dr. Singh serves on the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arms-length funding from 12 pharmaceutical companies. Dr. Singh serves on the FDA Arthritis Advisory Committee. Dr. Singh is a member of the Veterans Affairs Rheumatology Field Advisory Committee. Dr. Singh is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, outside the submitted work. Dr. Stein reports personal fees from Lundbeck and Sun, outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

Published
2020
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4. The global burden of falls: global, regional and national estimates of morbidity and mortality from the Global Burden of Disease Study 2017.

Author

James SL, Lucchesi LR, Bisignano C, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Henry NJ, Krohn KJ, Liu Z, McCracken D, Nixon MR, Roberts NLS, Sylte DO, Adsuar JC, Arora A, Briggs AM, Collado-Mateo D, Cooper C, Dandona L, Dandona R, Ellingsen CL, Fereshtehnejad SM, Gill TK, Haagsma JA, Hendrie D, Jürisson M, Kumar GA, Lopez AD, Miazgowski T, Miller TR, Mini GK, Mirrakhimov EM, Mohamadi E, Olivares PR, Rahim F, Riera LS, Villafaina S, Yano Y, Hay SI, Lim SS, Mokdad AH, Naghavi M, and Murray CJL

Subjects
Global Health, Humans, Incidence, Life Expectancy, Morbidity, Prevalence, Quality-Adjusted Life Years, Accidental Falls, Global Burden of Disease
Abstract

Background: Falls can lead to severe health loss including death. Past research has shown that falls are an important cause of death and disability worldwide. The Global Burden of Disease Study 2017 (GBD 2017) provides a comprehensive assessment of morbidity and mortality from falls., Methods: Estimates for mortality, years of life lost (YLLs), incidence, prevalence, years lived with disability (YLDs) and disability-adjusted life years (DALYs) were produced for 195 countries and territories from 1990 to 2017 for all ages using the GBD 2017 framework. Distributions of the bodily injury (eg, hip fracture) were estimated using hospital records., Results: Globally, the age-standardised incidence of falls was 2238 (1990-2532) per 100 000 in 2017, representing a decline of 3.7% (7.4 to 0.3) from 1990 to 2017. Age-standardised prevalence was 5186 (4622-5849) per 100 000 in 2017, representing a decline of 6.5% (7.6 to 5.4) from 1990 to 2017. Age-standardised mortality rate was 9.2 (8.5-9.8) per 100 000 which equated to 695 771 (644 927-741 720) deaths in 2017. Globally, falls resulted in 16 688 088 (15 101 897-17 636 830) YLLs, 19 252 699 (13 725 429-26 140 433) YLDs and 35 940 787 (30 185 695-42 903 289) DALYs across all ages. The most common injury sustained by fall victims is fracture of patella, tibia or fibula, or ankle. Globally, age-specific YLD rates increased with age., Conclusions: This study shows that the burden of falls is substantial. Investing in further research, fall prevention strategies and access to care is critical., Competing Interests: Competing interests: SJ reports grants from Sanofi Pasteur outside the submitted work; AB reports personal fees from World Health Organization outside the submitted work; CC reports personal fees from Amgen, personal fees from Danone, personal fees from Eli Lilly, personal fees from GlaxoSmithKline, personal fees from Kyowa Kirin, personal fees from Medtronic, personal fees from Merck, personal fees from Nestle, personal fees from Novartis, personal fees from Pfizer, personal fees from Roche, personal fees from Servier, personal fees from Shire, personal fees from Takeda, and personal fees from UCB outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

Published
2020
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5. Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017.

Author

James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, S Roberts NL, Sylte DO, Henry NJ, LeGrand KE, Abdelalim A, Abdoli A, Abdollahpour I, Abdulkader RS, Abedi A, Abosetugn AE, Abushouk AI, Adebayo OM, Agudelo-Botero M, Ahmad T, Ahmed R, Ahmed MB, Eddine Aichour MT, Alahdab F, Alamene GM, Alanezi FM, Alebel A, Alema NM, Alghnam SA, Al-Hajj S, Ali BA, Ali S, Alikhani M, Alinia C, Alipour V, Aljunid SM, Almasi-Hashiani A, Almasri NA, Altirkawi K, Abdeldayem Amer YS, Amini S, Loreche Amit AM, Andrei CL, Ansari-Moghaddam A, T Antonio CA, Yaw Appiah SC, Arabloo J, Arab-Zozani M, Arefi Z, Aremu O, Ariani F, Arora A, Asaad M, Asghari B, Awoke N, Ayala Quintanilla BP, Ayano G, Ayanore MA, Azari S, Azarian G, Badawi A, Badiye AD, Bagli E, Baig AA, Bairwa M, Bakhtiari A, Balachandran A, Banach M, Banerjee SK, Banik PC, Banstola A, Barker-Collo SL, Bärnighausen TW, Barrero LH, Barzegar A, Bayati M, Baye BA, Bedi N, Behzadifar M, Bekuma TT, Belete H, Benjet C, Bennett DA, Bensenor IM, Berhe K, Bhardwaj P, Bhat AG, Bhattacharyya K, Bibi S, Bijani A, Bin Sayeed MS, Borges G, Borzì AM, Boufous S, Brazinova A, Briko NI, Budhathoki SS, Car J, Cárdenas R, Carvalho F, Castaldelli-Maia JM, Castañeda-Orjuela CA, Castelpietra G, Catalá-López F, Cerin E, Chandan JS, Chanie WF, Chattu SK, Chattu VK, Chatziralli I, Chaudhary N, Cho DY, Kabir Chowdhury MA, Chu DT, Colquhoun SM, Constantin MM, Costa VM, Damiani G, Daryani A, Dávila-Cervantes CA, Demeke FM, Demis AB, Demoz GT, Demsie DG, Derakhshani A, Deribe K, Desai R, Nasab MD, da Silva DD, Dibaji Forooshani ZS, Doyle KE, Driscoll TR, Dubljanin E, Adema BD, Eagan AW, Eftekhari A, Ehsani-Chimeh E, Sayed Zaki ME, Elemineh DA, El-Jaafary SI, El-Khatib Z, Ellingsen CL, Emamian MH, Endalew DA, Eskandarieh S, Faris PS, Faro A, Farzadfar F, Fatahi Y, Fekadu W, Ferede TY, Fereshtehnejad SM, Fernandes E, Ferrara P, Feyissa GT, Filip I, Fischer F, Folayan MO, Foroutan M, Francis JM, Franklin RC, Fukumoto T, Geberemariyam BS, Gebre AK, Gebremedhin KB, Gebremeskel GG, Gebremichael B, Gedefaw GA, Geta B, Ghafourifard M, Ghamari F, Ghashghaee A, Gholamian A, Gill TK, Goulart AC, Grada A, Grivna M, Mohialdeen Gubari MI, Guimarães RA, Guo Y, Gupta G, Haagsma JA, Hafezi-Nejad N, Bidgoli HH, Hall BJ, Hamadeh RR, Hamidi S, Haro JM, Hasan MM, Hasanzadeh A, Hassanipour S, Hassankhani H, Hassen HY, Havmoeller R, Hayat K, Hendrie D, Heydarpour F, Híjar M, Ho HC, Hoang CL, Hole MK, Holla R, Hossain N, Hosseinzadeh M, Hostiuc S, Hu G, Ibitoye SE, Ilesanmi OS, Ilic I, Ilic MD, Inbaraj LR, Indriasih E, Naghibi Irvani SS, Shariful Islam SM, Islam MM, Ivers RQ, Jacobsen KH, Jahani MA, Jahanmehr N, Jakovljevic M, Jalilian F, Jayaraman S, Jayatilleke AU, Jha RP, John-Akinola YO, Jonas JB, Joseph N, Joukar F, Jozwiak JJ, Jungari SB, Jürisson M, Kabir A, Kadel R, Kahsay A, Kalankesh LR, Kalhor R, Kamil TA, Kanchan T, Kapoor N, Karami M, Kasaeian A, Kassaye HG, Kavetskyy T, Kebede HK, Keiyoro PN, Kelbore AG, Kelkay B, Khader YS, Khafaie MA, Khalid N, Khalil IA, Khalilov R, Khammarnia M, Khan EA, Khan M, Khanna T, Khazaie H, Shadmani FK, Khundkar R, Kiirithio DN, Kim YE, Kim D, Kim YJ, Kisa A, Kisa S, Komaki H, M Kondlahalli SK, Korshunov VA, Koyanagi A, G Kraemer MU, Krishan K, Bicer BK, Kugbey N, Kumar V, Kumar N, Kumar GA, Kumar M, Kumaresh G, Kurmi OP, Kuti O, Vecchia C, Lami FH, Lamichhane P, Lang JJ, Lansingh VC, Laryea DO, Lasrado S, Latifi A, Lauriola P, Leasher JL, Huey Lee SW, Lenjebo TL, Levi M, Li S, Linn S, Liu X, Lopez AD, Lotufo PA, Lunevicius R, Lyons RA, Madadin M, El Razek MMA, Mahotra NB, Majdan M, Majeed A, Malagon-Rojas JN, Maled V, Malekzadeh R, Malta DC, Manafi N, Manafi A, Manda AL, Manjunatha N, Mansour-Ghanaei F, Mansouri B, Mansournia MA, Maravilla JC, March LM, Mason-Jones AJ, Masoumi SZ, Massenburg BB, Maulik PK, Meles GG, Melese A, Melketsedik ZA, N Memiah PT, Mendoza W, Menezes RG, Mengesha MB, Mengesha MM, Meretoja TJ, Meretoja A, Merie HE, Mestrovic T, Miazgowski B, Miazgowski T, Miller TR, Mini GK, Mirica A, Mirrakhimov EM, Mirzaei-Alavijeh M, Mithra P, Moazen B, Moghadaszadeh M, Mohamadi E, Mohammad Y, Mohammad KA, Darwesh AM, Gholi Mezerji NM, Mohammadian-Hafshejani A, Mohammadoo-Khorasani M, Mohammadpourhodki R, Mohammed S, Mohammed JA, Mohebi F, Molokhia M, Monasta L, Moodley Y, Moosazadeh M, Moradi M, Moradi G, Moradi-Lakeh M, Moradpour F, Morawska L, Velásquez IM, Morisaki N, Morrison SD, Mossie TB, Muluneh AG, Murthy S, Musa KI, Mustafa G, Nabhan AF, Nagarajan AJ, Naik G, Naimzada MD, Najafi F, Nangia V, Nascimento BR, Naserbakht M, Nayak V, Ndwandwe DE, Negoi I, Ngunjiri JW, Nguyen CT, Thi Nguyen HL, Nikbakhsh R, Anggraini Ningrum DN, Nnaji CA, Nyasulu PS, Ogbo FA, Oghenetega OB, Oh IH, Okunga EW, Olagunju AT, Olagunju TO, Bali AO, Onwujekwe OE, Asante KO, Orpana HM, Ota E, Otstavnov N, Otstavnov SS, A MP, Padubidri JR, Pakhale S, Pakshir K, Panda-Jonas S, Park EK, Patel SK, Pathak A, Pati S, Patton GC, Paulos K, Peden AE, Filipino Pepito VC, Pereira J, Pham HQ, Phillips MR, Pinheiro M, Polibin RV, Polinder S, Poustchi H, Prakash S, Angga Pribadi DR, Puri P, Syed ZQ, Rabiee M, Rabiee N, Radfar A, Rafay A, Rafiee A, Rafiei A, Rahim F, Rahimi S, Rahimi-Movaghar V, Rahman MA, Rajabpour-Sanati A, Rajati F, Rakovac I, Ranganathan K, Rao SJ, Rashedi V, Rastogi P, Rathi P, Rawaf S, Rawal L, Rawassizadeh R, Renjith V, N Renzaho AM, Resnikoff S, Rezapour A, Ribeiro AI, Rickard J, Rios González CM, Ronfani L, Roshandel G, Saad AM, Sabde YD, Sabour S, Saddik B, Safari S, Safari-Faramani R, Safarpour H, Safdarian M, Sajadi SM, Salamati P, Salehi F, Zahabi SS, Rashad Salem MR, Salem H, Salman O, Salz I, Samy AM, Sanabria J, Riera LS, Santric Milicevic MM, Sarker AR, Sarveazad A, Sathian B, Sawhney M, Sawyer SM, Saxena S, Sayyah M, Schwebel DC, Seedat S, Senthilkumaran S, Sepanlou SG, Seyedmousavi S, Sha F, Shaahmadi F, Shahabi S, Shaikh MA, Shams-Beyranvand M, Shamsizadeh M, Sharif-Alhoseini M, Sharifi H, Sheikh A, Shigematsu M, Shin JI, Shiri R, Siabani S, Sigfusdottir ID, Singh PK, Singh JA, Sinha DN, Smarandache CG, R Smith EU, Soheili A, Soleymani B, Soltanian AR, Soriano JB, Sorrie MB, Soyiri IN, Stein DJ, Stokes MA, Sufiyan MB, Rasul Suleria HA, Sykes BL, Tabarés-Seisdedos R, Tabb KM, Taddele BW, Tadesse DB, Tamiru AT, Tarigan IU, Tefera YM, Tehrani-Banihashemi A, Tekle MG, Tekulu GH, Tesema AK, Tesfay BE, Thapar R, Tilahune AB, Tlaye KG, Tohidinik HR, Topor-Madry R, Tran BX, Tran KB, Tripathy JP, Tsai AC, Car LT, Ullah S, Ullah I, Umar M, Unnikrishnan B, Upadhyay E, Uthman OA, Valdez PR, Vasankari TJ, Venketasubramanian N, Violante FS, Vlassov V, Waheed Y, Weldesamuel GT, Werdecker A, Wiangkham T, Wolde HF, Woldeyes DH, Wondafrash DZ, Wondmeneh TG, Wondmieneh AB, Wu AM, Yadav R, Yadollahpour A, Yano Y, Yaya S, Yazdi-Feyzabadi V, Yip P, Yisma E, Yonemoto N, Yoon SJ, Youm Y, Younis MZ, Yousefi Z, Yu Y, Yu C, Yusefzadeh H, Moghadam TZ, Zaidi Z, Zaman SB, Zamani M, Zamanian M, Zandian H, Zarei A, Zare F, Zhang ZJ, Zhang Y, Zodpey S, Dandona L, Dandona R, Degenhardt L, Dharmaratne SD, Hay SI, Mokdad AH, Reiner RC Jr, Sartorius B, and Vos T

Subjects
Humans, Incidence, Life Expectancy, Morbidity, Quality-Adjusted Life Years, Global Burden of Disease, Global Health, Wounds and Injuries mortality
Abstract

Background: Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries., Methods: We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs)., Findings: In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505)., Interpretation: Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care., Competing Interests: Competing interests: Dr. James reports grants from Sanofi Pasteur, outside the submitted work. Dr. Driscoll reports grants from World Health Organization, during the conduct of the study. Dr. Ivers reports grants from National Health and Medical Research Council of Australia, during the conduct of the study. Dr. Jozwiak reports personal fees from TEVA, personal fees from ALAB, personal fees from BOEHRINGER INGELHEIM, personal fees from SYNEXUS, non-financial support from SERVIER, non-financial support from MICROLIFE, non-financial support from MEDICOVER, outside the submitted work. Dr. Rakovac reports grants from World Health Organization, during the conduct of the study. Dr Shariful Islam is funded by National Heart Foundation of Australia and Institute for Physical Activity and Nutrition, Deakin University. Dr. Sheikh reports grants from Health Data Research UK, outside the submitted work. Dr. Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio health, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Spherix, Practice Point communications, the National Institutes of Health and the American College of Rheumatology, and Speaker’s bureau of Simply Speaking, owns stock options in Amarin pharmaceuticals and Viking pharmaceuticals, serves on the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arm’s length funding from 12 pharmaceutical companies, serves on the FDA Arthritis Advisory Committee, is a member of the Veterans Affairs Rheumatology Field Advisory Committee, and is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, outside the submitted work. Dr. Stein reports personal fees from Lundbeck, personal fees from Sun, outside the submitted work. Dr. Degenhardt reports grants from Indivior, Seqirus, Reckitt Benckiser, outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

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2020
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6. Global trends of hand and wrist trauma: a systematic analysis of fracture and digit amputation using the Global Burden of Disease 2017 Study.

Author

Crowe CS, Massenburg BB, Morrison SD, Chang J, Friedrich JB, Abady GG, Alahdab F, Alipour V, Arabloo J, Asaad M, Banach M, Bijani A, Borzì AM, Briko NI, Castle CD, Cho DY, Chung MT, Daryani A, Demoz GT, Dingels ZV, Do HT, Fischer F, Fox JT, Fukumoto T, Gebre AK, Gebremichael B, Haagsma JA, Haj-Mirzaian A, Handiso DW, Hay SI, Hoang CL, Irvani SSN, Jozwiak JJ, Kalhor R, Kasaeian A, Khader YS, Khalilov R, Khan EA, Khundkar R, Kisa S, Kisa A, Liu Z, Majdan M, Manafi N, Manafi A, Manda AL, Meretoja TJ, Miller TR, Mohammadian-Hafshejani A, Mohammadpourhodki R, Mohseni Bandpei MA, Mokdad AH, Naimzada MD, Ndwandwe DE, Nguyen CT, Nguyen HLT, Olagunju AT, Olagunju TO, Pham HQ, Pribadi DRA, Rabiee N, Ramezanzadeh K, Ranganathan K, Roberts NLS, Roever L, Safari S, Samy AM, Sanchez Riera L, Shahabi S, Smarandache CG, Sylte DO, Tesfay BE, Tran BX, Ullah I, Vahedi P, Vahedian-Azimi A, Vos T, Woldeyes DH, Wondmieneh AB, Zhang ZJ, and James SL

Subjects
Amputation, Surgical, Female, Global Health, Humans, Incidence, Male, Prevalence, Quality-Adjusted Life Years, Global Burden of Disease, Hand Injuries surgery, Wrist, Wrist Injuries surgery
Abstract

Background: As global rates of mortality decrease, rates of non-fatal injury have increased, particularly in low Socio-demographic Index (SDI) nations. We hypothesised this global pattern of non-fatal injury would be demonstrated in regard to bony hand and wrist trauma over the 27-year study period., Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 was used to estimate prevalence, age-standardised incidence and years lived with disability for hand trauma in 195 countries from 1990 to 2017. Individual injuries included hand and wrist fractures, thumb amputations and non-thumb digit amputations., Results: The global incidence of hand trauma has only modestly decreased since 1990. In 2017, the age-standardised incidence of hand and wrist fractures was 179 per 100 000 (95% uncertainty interval (UI) 146 to 217), whereas the less common injuries of thumb and non-thumb digit amputation were 24 (95% UI 17 to 34) and 56 (95% UI 43 to 74) per 100 000, respectively. Rates of injury vary greatly by region, and improvements have not been equally distributed. The highest burden of hand trauma is currently reported in high SDI countries. However, low-middle and middle SDI countries have increasing rates of hand trauma by as much at 25%., Conclusions: Certain regions are noted to have high rates of hand trauma over the study period. Low-middle and middle SDI countries, however, have demonstrated increasing rates of fracture and amputation over the last 27 years. This trend is concerning as access to quality and subspecialised surgical hand care is often limiting in these resource-limited regions., Competing Interests: Competing interests: Dr. Jozwiak reports personal fees from TEVA, personal fees from ALAB, personal fees from BOEHRINGER INGELHEIM, personal fees from SYNEXUS, non-financial support from SERVIER, non-financial support from MICROLIFE, and non-financial support from MEDICOVER, outside the submitted work. Dr. James reports grants from Sanofi Pasteur, outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

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2020
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7. Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017.

Author

Haagsma JA, James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, Lucchesi LR, Roberts NLS, Sylte DO, Adebayo OM, Ahmadi A, Ahmed MB, Aichour MTE, Alahdab F, Alghnam SA, Aljunid SM, Al-Raddadi RM, Alsharif U, Altirkawi K, Anjomshoa M, Antonio CAT, Appiah SCY, Aremu O, Arora A, Asayesh H, Assadi R, Awasthi A, Ayala Quintanilla BP, Balalla S, Banstola A, Barker-Collo SL, Bärnighausen TW, Bazargan-Hejazi S, Bedi N, Behzadifar M, Behzadifar M, Benjet C, Bennett DA, Bensenor IM, Bhaumik S, Bhutta ZA, Bijani A, Borges G, Borschmann R, Bose D, Boufous S, Brazinova A, Campuzano Rincon JC, Cárdenas R, Carrero JJ, Carvalho F, Castañeda-Orjuela CA, Catalá-López F, Choi JJ, Christopher DJ, Crowe CS, Dalal K, Daryani A, Davitoiu DV, Degenhardt L, De Leo D, De Neve JW, Deribe K, Dessie GA, deVeber GA, Dharmaratne SD, Doan LP, Dolan KA, Driscoll TR, Dubey M, El-Khatib Z, Ellingsen CL, El Sayed Zaki M, Endries AY, Eskandarieh S, Faro A, Fereshtehnejad SM, Fernandes E, Filip I, Fischer F, Franklin RC, Fukumoto T, Gezae KE, Gill TK, Goulart AC, Grada A, Guo Y, Gupta R, Haghparast Bidgoli H, Haj-Mirzaian A, Haj-Mirzaian A, Hamadeh RR, Hamidi S, Haro JM, Hassankhani H, Hassen HY, Havmoeller R, Hendrie D, Henok A, Híjar M, Hole MK, Homaie Rad E, Hossain N, Hostiuc S, Hu G, Igumbor EU, Ilesanmi OS, Irvani SSN, Islam SMS, Ivers RQ, Jacobsen KH, Jahanmehr N, Jakovljevic M, Jayatilleke AU, Jha RP, Jonas JB, Jorjoran Shushtari Z, Jozwiak JJ, Jürisson M, Kabir A, Kalani R, Kasaeian A, Kelbore AG, Kengne AP, Khader YS, Khafaie MA, Khalid N, Khan EA, Khoja AT, Kiadaliri AA, Kim YE, Kim D, Kisa A, Koyanagi A, Kuate Defo B, Kucuk Bicer B, Kumar M, Lalloo R, Lam H, Lami FH, Lansingh VC, Leasher JL, Li S, Linn S, Lunevicius R, Machado FR, Magdy Abd El Razek H, Magdy Abd El Razek M, Mahotra NB, Majdan M, Majeed A, Malekzadeh R, Malik MA, Malta DC, Manda AL, Mansournia MA, Massenburg BB, Maulik PK, Meheretu HAA, Mehndiratta MM, Melese A, Mendoza W, Mengesha MM, Meretoja TJ, Meretoja A, Mestrovic T, Miazgowski T, Miller TR, Mini GK, Mirrakhimov EM, Moazen B, Mohammad Gholi Mezerji N, Mohammadibakhsh R, Mohammed S, Molokhia M, Monasta L, Mondello S, Montero-Zamora PA, Moodley Y, Moosazadeh M, Moradi G, Moradi-Lakeh M, Morawska L, Velásquez IM, Morrison SD, Moschos MM, Mousavi SM, Murthy S, Musa KI, Naik G, Najafi F, Nangia V, Nascimento BR, Ndwandwe DE, Negoi I, Nguyen TH, Nguyen SH, Nguyen LH, Nguyen HLT, Ningrum DNA, Nirayo YL, Ofori-Asenso R, Ogbo FA, Oh IH, Oladimeji O, Olagunju AT, Olagunju TO, Olivares PR, Orpana HM, Otstavnov SS, P A M, Pakhale S, Park EK, Patton GC, Pesudovs K, Phillips MR, Polinder S, Prakash S, Radfar A, Rafay A, Rafiei A, Rahimi S, Rahimi-Movaghar V, Rahman MA, Rai RK, Ramezanzadeh K, Rawaf S, Rawaf DL, Renzaho AMN, Resnikoff S, Rezaeian S, Roever L, Ronfani L, Roshandel G, Sabde YD, Saddik B, Salamati P, Salimi Y, Salz I, Samy AM, Sanabria J, Sanchez Riera L, Santric Milicevic MM, Satpathy M, Sawhney M, Sawyer SM, Saxena S, Saylan M, Schneider IJC, Schwebel DC, Seedat S, Sepanlou SG, Shaikh MA, Shams-Beyranvand M, Shamsizadeh M, Sharif-Alhoseini M, Sheikh A, Shen J, Shigematsu M, Shiri R, Shiue I, Silva JP, Singh JA, Sinha DN, Soares Filho AM, Soriano JB, Soshnikov S, Soyiri IN, Starodubov VI, Stein DJ, Stokes MA, Sufiyan MB, Sunshine JE, Sykes BL, Tabarés-Seisdedos R, Tabb KM, Tehrani-Banihashemi A, Tessema GA, Thakur JS, Tran KB, Tran BX, Tudor Car L, Uthman OA, Uzochukwu BSC, Valdez PR, Varavikova E, Vasconcelos AMN, Venketasubramanian N, Violante FS, Vlassov V, Waheed Y, Wang YP, Wijeratne T, Winkler AS, Yadav P, Yano Y, Yenesew MA, Yip P, Yisma E, Yonemoto N, Younis MZ, Yu C, Zafar S, Zaidi Z, Zaman SB, Zamani M, Zhao Y, Zodpey S, Hay SI, Lopez AD, Mokdad AH, and Vos T

Subjects
Adolescent, Global Health, Humans, Life Expectancy, Disabled Persons, Global Burden of Disease, Quality-Adjusted Life Years, Wounds and Injuries
Abstract

Background: The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates., Methods: Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate., Results: For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced., Conclusions: The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum., Competing Interests: Competing interests: Dr. Carl Abelardo T Antonio reports personal fees from Johnson & Johnson (Philippines), Inc., outside the submitted work. Dr. Jasvinder Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Spherix, the National Institutes of Health and the American College of Rheumatology, stock options in Amarin pharmaceuticals and Viking pharmaceuticals, participating in the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arm’s length funding from 12 pharmaceutical companies, including Amgen, Janssen, Novartis, Roche, UCB Group, Ardea/Astra Zeneca, Bristol Myers Squibb, Celgene, EliLilly, Horizon Pharma, Pfizer, and Centrexion. Dr. Josep Maria Haro reports personal fees from Roche and Lundbeck, and that the institute for which they work provides services to Eli Lilly and Co., outside the submitted work. Dr. Mete Saylan is an employee of Bayer AG, outside the submitted work. Dr Sheikh Mohammed Shariful Islam is funded by National Heart Foundation of Australia and supported by a senior research fellowship from Deakin University, outside the submitted work. Dr. Spencer James reports grants from Sanofi Pasteur, outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

Published
2020
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8. The burden of unintentional drowning: global, regional and national estimates of mortality from the Global Burden of Disease 2017 Study.

Author

Franklin RC, Peden AE, Hamilton EB, Bisignano C, Castle CD, Dingels ZV, Hay SI, Liu Z, Mokdad AH, Roberts NLS, Sylte DO, Vos T, Abady GG, Abosetugn AE, Ahmed R, Alahdab F, Andrei CL, Antonio CAT, Arabloo J, Arba AAK, Badiye AD, Bakkannavar SM, Banach M, Banik PC, Banstola A, Barker-Collo SL, Barzegar A, Bayati M, Bhardwaj P, Bhaumik S, Bhutta ZA, Bijani A, Boloor A, Carvalho F, Chowdhury MAK, Chu DT, Colquhoun SM, Dagne H, Dagnew B, Dandona L, Dandona R, Daryani A, Dharmaratne SD, Dibaji Forooshani ZS, Do HT, Driscoll TR, Eagan AW, El-Khatib Z, Fernandes E, Filip I, Fischer F, Gebremichael B, Gupta G, Haagsma JA, Hassan S, Hendrie D, Hoang CL, Hole MK, Holla R, Hostiuc S, Househ M, Ilesanmi OS, Inbaraj LR, Irvani SSN, Islam MM, Ivers RQ, Jayatilleke AU, Joukar F, Kalhor R, Kanchan T, Kapoor N, Kasaeian A, Khan M, Khan EA, Khubchandani J, Krishan K, Kumar GA, Lauriola P, Lopez AD, Madadin M, Majdan M, Maled V, Manafi N, Manafi A, McKee M, Meles HG, Menezes RG, Meretoja TJ, Miller TR, Mithra P, Mohammadian-Hafshejani A, Mohammadpourhodki R, Mohebi F, Molokhia M, Mustafa G, Negoi I, Nguyen CT, Nguyen HLT, Olagunju AT, Olagunju TO, Padubidri JR, Pakshir K, Pathak A, Polinder S, Pribadi DRA, Rabiee N, Radfar A, Rana SM, Rickard J, Safari S, Salamati P, Samy AM, Sarker AR, Schwebel DC, Senthilkumaran S, Shaahmadi F, Shaikh MA, Shin JI, Singh PK, Soheili A, Stokes MA, Suleria HAR, Tarigan IU, Temsah MH, Tesfay BE, Valdez PR, Veisani Y, Ye P, Yonemoto N, Yu C, Yusefzadeh H, Zaman SB, Zhang ZJ, and James SL

Subjects
Bangladesh epidemiology, Child, China epidemiology, Female, Global Health, Humans, India epidemiology, Male, Quality-Adjusted Life Years, Drowning mortality, Global Burden of Disease
Abstract

Background: Drowning is a leading cause of injury-related mortality globally. Unintentional drowning (International Classification of Diseases (ICD) 10 codes W65-74 and ICD9 E910) is one of the 30 mutually exclusive and collectively exhaustive causes of injury-related mortality in the Global Burden of Disease (GBD) study. This study's objective is to describe unintentional drowning using GBD estimates from 1990 to 2017., Methods: Unintentional drowning from GBD 2017 was estimated for cause-specific mortality and years of life lost (YLLs), age, sex, country, region, Socio-demographic Index (SDI) quintile, and trends from 1990 to 2017. GBD 2017 used standard GBD methods for estimating mortality from drowning., Results: Globally, unintentional drowning mortality decreased by 44.5% between 1990 and 2017, from 531 956 (uncertainty interval (UI): 484 107 to 572 854) to 295 210 (284 493 to 306 187) deaths. Global age-standardised mortality rates decreased 57.4%, from 9.3 (8.5 to 10.0) in 1990 to 4.0 (3.8 to 4.1) per 100 000 per annum in 2017. Unintentional drowning-associated mortality was generally higher in children, males and in low-SDI to middle-SDI countries. China, India, Pakistan and Bangladesh accounted for 51.2% of all drowning deaths in 2017. Oceania was the region with the highest rate of age-standardised YLLs in 2017, with 45 434 (40 850 to 50 539) YLLs per 100 000 across both sexes., Conclusions: There has been a decline in global drowning rates. This study shows that the decline was not consistent across countries. The results reinforce the need for continued and improved policy, prevention and research efforts, with a focus on low- and middle-income countries., Competing Interests: Competing interests: Dr. Franklin reports receiving airfare reimbursement from Royal Life Saving Society - Australia, during the conduct of the study. Dr. Bhaumik reports grants from Royal National Lifeboat Institution, UK, outside the submitted work. Dr. Driscoll reports grants from World Health Organization, during the conduct of the study. Dr. Ivers reports grants from Royal National LifeBoat Institute, outside the submitted work. Dr. Khubchandani reports grants from Merck Research Laboratories, outside the submitted work. Dr. James reports grants from Sanofi Pasteur, outside the submitted work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

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2020
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9. Epidemiology of facial fractures: incidence, prevalence and years lived with disability estimates from the Global Burden of Disease 2017 study.

Author

Lalloo R, Lucchesi LR, Bisignano C, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, Roberts NLS, Sylte DO, Alahdab F, Alipour V, Alsharif U, Arabloo J, Bagherzadeh M, Banach M, Bijani A, Crowe CS, Daryani A, Do HP, Doan LP, Fischer F, Gebremeskel GG, Haagsma JA, Haj-Mirzaian A, Haj-Mirzaian A, Hamidi S, Hoang CL, Irvani SSN, Kasaeian A, Khader YS, Khalilov R, Khoja AT, Kiadaliri AA, Majdan M, Manaf N, Manafi A, Massenburg BB, Mohammadian-Hafshejani A, Morrison SD, Nguyen TH, Nguyen SH, Nguyen CT, Olagunju TO, Otstavnov N, Polinder S, Rabiee N, Rabiee M, Ramezanzadeh K, Ranganathan K, Rezapour A, Safari S, Samy AM, Sanchez Riera L, Shaikh MA, Tran BX, Vahedi P, Vahedian-Azimi A, Zhang ZJ, Pigott DM, Hay SI, Mokdad AH, and James SL

Subjects
Brazil, Canada, Europe, Global Health, Humans, Incidence, Prevalence, Quality-Adjusted Life Years, State Medicine, Fractures, Bone, Global Burden of Disease, Quality of Life
Abstract

Background: The Global Burden of Disease Study (GBD) has historically produced estimates of causes of injury such as falls but not the resulting types of injuries that occur. The objective of this study was to estimate the global incidence, prevalence and years lived with disability (YLDs) due to facial fractures and to estimate the leading injurious causes of facial fracture., Methods: We obtained results from GBD 2017. First, the study estimated the incidence from each injury cause (eg, falls), and then the proportion of each cause that would result in facial fracture being the most disabling injury. Incidence, prevalence and YLDs of facial fractures are then calculated across causes., Results: Globally, in 2017, there were 7 538 663 (95% uncertainty interval 6 116 489 to 9 493 113) new cases, 1 819 732 (1 609 419 to 2 091 618) prevalent cases, and 117 402 (73 266 to 169 689) YLDs due to facial fractures. In terms of age-standardised incidence, prevalence and YLDs, the global rates were 98 (80 to 123) per 100 000, 23 (20 to 27) per 100 000, and 2 (1 to 2) per 100 000, respectively. Facial fractures were most concentrated in Central Europe. Falls were the predominant cause in most regions., Conclusions: Facial fractures are predominantly caused by falls and occur worldwide. Healthcare systems and public health agencies should investigate methods of all injury prevention. It is important for healthcare systems in every part of the world to ensure access to treatment resources., Competing Interests: Competing interests: SLJ works on a grant for influenza and respiratory syncytial disease that is funded by Sanofi Pasteur. This work does not relate to facial fracture burden., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

Published
2020
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10. Comparison of three different methods to estimate the burden of disease of burn injuries in Western Australia in 2011-2018.

Author

Spronk I, Haagsma JA, Edgar DW, van Baar ME, Polinder S, and Wood FM

Subjects
Body Surface Area, Burns epidemiology, Burns pathology, Burns, Inhalation epidemiology, Burns, Inhalation physiopathology, Craniocerebral Trauma pathology, Craniocerebral Trauma physiopathology, Hand Injuries pathology, Hand Injuries physiopathology, Hospitalization statistics & numerical data, Humans, Neck Injuries pathology, Neck Injuries physiopathology, Western Australia epidemiology, Wrist Injuries pathology, Wrist Injuries physiopathology, Burns physiopathology, Global Burden of Disease, Quality-Adjusted Life Years
Abstract

Background: Priority setting and resource allocation in health care, surveillance and interventions is based increasingly on burden of disease. Several methods exist to calculate the non-fatal burden of disease of burns expressed in years lived with disability (YLDs). The aim of this study was to assess the burden of disease due to burns in Western Australia 2011-2018 and compare YLD outcomes between three existing methods., Methods: Data from the Burns Service of Western Australia was used. Three existing methods to assess YLDs were compared: the Global Burden of Disease (GBD) method, a method dedicated to assess injury YLDs (Injury-VIBES), and a method dedicated to assess burns YLDs (INTEGRIS-burns)., Results: Incidence data from 2,866 burn patients were used. Non-fatal burden of disease estimates differed substantially between the different methods. Estimates for 2011-2018 ranged between 610 and 1,085 YLDs per 100.000 based on the Injury-VIBES method; between 209 and 324 YLDs based on the INTEGRIS-burns method; and between 89 and 120 YLDs based on the GBD method. YLDs per case were three to nine times higher when the Injury-VIBES method was applied compared to the other methods. Also trends in time differed widely through application of the different methods. There was a strong increase in YLDs over the years when the Injury-VIBES method was applied, a slight increase when the INTEGRIS-burns method was applied and a stable pattern when the GBD method was applied., Conclusion: This study showed that the choice for a specific method heavily influences the non-fatal burden of disease expressed in YLDs, both in terms of annual estimates as well as in trends over time. By addressing the methodological limitations evident in previously published calculations of the non-fatal burden of disease, the INTEGRIS-burns seems to present a method to provide the most robust estimates to date, as it is the only method adapted to the nature of burn injuries and their recovery., (Copyright © 2019 Elsevier Ltd and ISBI. All rights reserved.)

Published
2020
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11. The burden of injury in China, 1990-2017: findings from the Global Burden of Disease Study 2017.

Author

Leilei D, Pengpeng Y, Haagsma JA, Ye J, Yuan W, Yuliang E, Xiao D, Xin G, Cuirong J, Linhong W, Bannick MS, Mountjoy-Venning WC, Hawley CN, Liu Z, Smith M, James SL, Vos T, and Murray CJL

Subjects
Adolescent, Adult, Child, Child, Preschool, China epidemiology, Female, Humans, Incidence, Infant, Male, Middle Aged, Quality-Adjusted Life Years, Young Adult, Global Burden of Disease trends, Wounds and Injuries mortality
Abstract

Background: A comprehensive evaluation of the burden of injury is an important foundation for selecting and formulating strategies of injury prevention. We present results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 of non-fatal and fatal outcomes of injury at the national and subnational level, and the changes in burden for key causes of injury over time in China., Methods: Using the methods and results from GBD 2017, we describe the burden of total injury and the key causes of injury based on the rates of incidence, cause-specific mortality, and disability-adjusted life years (DALYs) in China estimated using DisMod-MR 2.1. We additionally evaluated these results at the provincial level for the 34 subnational locations of China in 2017, measured the change of injury burden from 1990 to 2017, and compared age-standardised DALYs due to injuries at the provincial level against the expected rates based on the Socio-demographic Index (SDI), a composite measure of development of income per capita, years of education, and total fertility rate., Findings: In 2017, in China, there were 77·1 million (95% uncertainty interval [UI] 72·5-81·6) new cases of injury severe enough to warrant health care and 733 517 deaths (681 254-767 006) due to injuries. Injuries accounted for 7·0% (95% UI 6·6-7·2) of total deaths and 10·0% (9·5-10·5) of all-cause DALYs in China. In 2017, there was a three-times variation in age-standardised injury DALY rates between provinces of China, with the lowest value in Macao and the highest in Yunnan. Between 1990 and 2017, the age-standardised incidence rate of all injuries increased by 50·6% (95% UI 46·6-54·6) in China, whereas the age-standardised mortality and DALY rates decreased by 44·3% (41·1-48·9) and 48·1% (44·6-51·8), respectively. Between 1990 and 2017, all provinces of China experienced a substantial decline in DALY rates from all injuries ranging from 16·3% (3·1-28·6) in Shanghai and 60·4% (53·7-66·1) in Jiangxi. Age-standardised DALY rates for drowning; injuries from fire, heat and hot substances; adverse effects of medical treatments; animal contact; environmental heat and cold exposure; self-harm; and executions and police conflict each declined by more than 60% between 1990 and 2017., Interpretation: Between 1990 and 2017, China experienced a decrease in the age-standardised DALY and mortality rates due to injury, despite an increase in the age-standardised incidence rate. These trends occurred in all provinces. The divergent trends in terms of incidence and mortality indicate that with rapid sociodemographic improvements, the case fatality of injuries has declined, which could be attributed to an improving health-care system but also to a decreasing severity of injuries over this time period., Funding: Bill & Melinda Gates Foundation., (Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)

Published
2019
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12. Global burden of melioidosis in 2015: a systematic review and data synthesis.

Author

Birnie E, Virk HS, Savelkoel J, Spijker R, Bertherat E, Dance DAB, Limmathurotsakul D, Devleesschauwer B, Haagsma JA, and Wiersinga WJ

Subjects
Burkholderia pseudomallei isolation & purification, Humans, Incidence, Melioidosis mortality, Neglected Diseases, Global Burden of Disease statistics & numerical data, Melioidosis epidemiology, Quality-Adjusted Life Years
Abstract

Background: Melioidosis is an infectious disease caused by the environmental bacterium Burkholderia pseudomallei. It is often fatal, with a high prevalence in tropical areas. Clinical presentation can vary from abscess formation to pneumonia and sepsis. We assessed the global burden of melioidosis, expressed in disability-adjusted life-years (DALYs), for 2015., Methods: We did a systematic review of the peer-reviewed literature for human melioidosis cases between Jan 1, 1990, and Dec 31, 2015. Quantitative data for cases of melioidosis were extracted, including mortality, age, sex, infectious and post-infectious sequelae, antibiotic treatment, and symptom duration. These data were combined with established disability weights and expert panel discussions to construct an incidence-based disease model. The disease model was integrated with established global incidence and mortality estimates to calculate global melioidosis DALYs. The study is registered with PROSPERO, number CRD42018106372., Findings: 2888 articles were screened, of which 475 eligible studies containing quantitative data were retained. Pneumonia, intra-abdominal abscess, and sepsis were the most common outcomes, with pneumonia occurring in 3633 (35·7%, 95% uncertainty interval [UI] 34·8-36·6) of 10 175 patients, intra-abdominal abscess in 1619 (18·3%, 17·5-19·1) of 8830 patients, and sepsis in 1526 (18·0%, 17·2-18·8) of 8469 patients. We estimate that in 2015, the global burden of melioidosis was 4·6 million DALYs (UI 3·2-6·6) or 84·3 per 100 000 people (57·5-120·0). Years of life lost accounted for 98·9% (UI 97·7-99·5) of the total DALYs, and years lived with disability accounted for 1·1% (0·5-2·3)., Interpretation: Melioidosis causes a larger disease burden than many other tropical diseases that are recognised as neglected, and so it should be reconsidered as a major neglected tropical disease., Funding: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Research Grant 2018, AMC PhD Scholarship, The Netherlands Organisation for Scientific Research (NWO), H2020 Marie Skłodowska-Curie Innovative Training Network European Sepsis Academy., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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13. Inequalities in the burden of non-communicable diseases across European countries: a systematic analysis of the Global Burden of Disease 2019 study

Author

Andrade, Carlos Alexandre Soares, Mahrouseh, Nour, Gabrani, Jonila, Charalampous, Periklis, Cuschieri, Sarah, Grad, Diana Alecsandra, Unim, Brigid, Mechili, Enkeleint A., Chen-Xu, José, Devleesschauwer, Brecht, Isola, Gaetano, von der Lippe, Elena, Baravelli, Carl Michael, Fischer, Florian, Weye, Nanna, Balaj, Mirza, Haneef, Romana, Economou, Mary, Haagsma, Juanita A., and Varga, Orsolya

Published
2023
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14. Alcohol control policy and alcohol‐attributable disease burden in Finland and the Baltic countries: A longitudinal study 1995–2019.

Author

Månsson, Anastasia, van der Velde, Lode, Karlsson, Thomas, Beekmann, Lauri, Jonsson Stenberg, Elsa, Haagsma, Juanita, Castelpietra, Giulio, Agardh, Emilie E., and Allebeck, Peter

Subjects
GLOBAL burden of disease, EARLY death, PANEL analysis, RANK correlation (Statistics), REGRESSION analysis
Abstract

Introduction: Alcohol remains a significant contributor to mortality and morbidity in Finland and the Baltic countries, particularly among men. This study aimed to assess alcohol policy restrictiveness in this region from 1995 to 2019 using a modified version of the Bridging the Gap (BtG‐M) policy scale and examine its association with alcohol‐related disease burden. Methods: The study utilised national laws to score policy restrictiveness (higher BtG‐M scores mean stricter policies) and age‐standardised rates of disability‐adjusted life years (DALY), years of life lost, years lived with disability and deaths per 100,000 from the 2019 Global Burden of Disease Study (GBD). Spearman correlation tests and panel data regression models were applied to assess the association between policy score and burden of disease. Results: Finland maintained a high BtG‐M score, while the Baltic countries experienced recent increases from initially lower scores. Alcohol‐related disease burden showed an inverse association with policy changes in these countries. Strongest association was seen between the BtG‐M score and DALY rates attributed to injuries. Premature mortality among men constituted the largest proportion of disease burden. Discussion and Conclusions: Despite challenges in accessing and comparing policy data over time, we showed a strong association between alcohol policy and alcohol‐related harm in Finland and the Baltic countries. This study is one of the first to use the BtG‐M scale to monitor changes in alcohol policies over time and their relationship to alcohol‐related harm using GBD methodology. The study highlights the effects of national alcohol policies on levels of alcohol‐related harm. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Burden of disease attributable to risk factors in European countries: a scoping literature review.

Author

Gorasso, Vanessa, Morgado, Joana Nazaré, Charalampous, Periklis, Pires, Sara M., Haagsma, Juanita A., Santos, João Vasco, Idavain, Jane, Ngwa, Che Henry, Noguer, Isabel, Padron-Monedero, Alicia, Sarmiento, Rodrigo, Pinheiro, Vera, Von der Lippe, Elena, Jakobsen, Lea Sletting, Devleesschauwer, Brecht, Plass, Dietrich, The COST Action CA18218 participants, Aasvang, Gunn Marit, Ádám, Balázs, and Alkerwi, Ala'a

Subjects
LITERATURE reviews, DISEASE risk factors, HEALTH websites, GLOBAL burden of disease, ENVIRONMENTAL risk
Abstract

Objectives: Within the framework of the burden of disease (BoD) approach, disease and injury burden estimates attributable to risk factors are a useful guide for policy formulation and priority setting in disease prevention. Considering the important differences in methods, and their impact on burden estimates, we conducted a scoping literature review to: (1) map the BoD assessments including risk factors performed across Europe; and (2) identify the methodological choices in comparative risk assessment (CRA) and risk assessment methods. Methods: We searched multiple literature databases, including grey literature websites and targeted public health agencies websites. Results: A total of 113 studies were included in the synthesis and further divided into independent BoD assessments (54 studies) and studies linked to the Global Burden of Disease (59 papers). Our results showed that the methods used to perform CRA varied substantially across independent European BoD studies. While there were some methodological choices that were more common than others, we did not observe patterns in terms of country, year or risk factor. Each methodological choice can affect the comparability of estimates between and within countries and/or risk factors, since they might significantly influence the quantification of the attributable burden. From our analysis we observed that the use of CRA was less common for some types of risk factors and outcomes. These included environmental and occupational risk factors, which are more likely to use bottom-up approaches for health outcomes where disease envelopes may not be available. Conclusions: Our review also highlighted misreporting, the lack of uncertainty analysis and the under-investigation of causal relationships in BoD studies. Development and use of guidelines for performing and reporting BoD studies will help understand differences, avoid misinterpretations thus improving comparability among estimates. Registration: The study protocol has been registered on PROSPERO, CRD42020177477 (available at: https://www.crd.york.ac.uk/PROSPERO/). [ABSTRACT FROM AUTHOR]

Published
2023
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16. The increasing significance of disease severity in a burden of disease framework.

Author

Wyper, Grant M.A., Assuncao, Ricardo, Fletcher, Eilidh, Gourley, Michelle, Grant, Ian, Haagsma, Juanita A., Hilderink, Henk, Idavain, Jane, Lesnik, Tina, von der Lippe, Elena, Majdan, Marek, Mccartney, Gerry, Santric-Milicevic, Milena, Pallari, Elena, Pires, Sara M., Plass, Dietrich, Porst, Michael, Santos, João V., de Haro Moro, Maria Teresa, and Stockton, Diane L.

Subjects
EVALUATION of medical care, HEALTH services accessibility, LIFE expectancy, GLOBAL burden of disease, CHRONIC diseases, SEVERITY of illness index, CONCEPTUAL structures, PEOPLE with disabilities, SOCIODEMOGRAPHIC factors
Abstract

Recent estimates have reiterated that non-fatal causes of disease, such as low back pain, headaches and depressive disorders, are amongst the leading causes of disability-adjusted life years (DALYs). For these causes, the contribution of years lived with disability (YLD) – put simply, ill-health – is what drives DALYs, not mortality. Being able to monitor trends in YLD closely is particularly relevant for countries that sit high on the socio-demographic spectrum of development, as it contributes more than half of all DALYs. There is a paucity of data on how the population-level occurrence of disease is distributed according to severity, and as such, the majority of global and national efforts in monitoring YLD lack the ability to differentiate changes in severity across time and location. This raises uncertainties in interpreting these findings without triangulation with other relevant data sources. Our commentary aims to bring this issue to the forefront for users of burden of disease estimates, as its impact is often easily overlooked as part of the fundamental process of generating DALY estimates. Moreover, the wider health harms of the COVID-19 pandemic have underlined the likelihood of latent and delayed demand in accessing vital health and care services that will ultimately lead to exacerbated disease severity and health outcomes. This places increased importance on attempts to be able to differentiate by both the occurrence and severity of disease. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Burden of non-communicable disease studies in Europe: a systematic review of data sources and methodological choices

Author

Mereke, Alibek, Von Der Lippe, Elena, Pires, Sara M, Plass, Dietrich, Gorasso, Vanessa, Charalampous, Periklis, Majer, Marjeta, Liew, Aaron, Ladeira, Carina, Mechili, Enkeleint A, Padron-Monedero, Alicia, O'caoimh, Rónán, Konar, Naime Meriç, Knudsen, Ann Kristin, Kabir, Zubair, Jakobsen, Lea S, Isola, Gaetano, Hynds, Paul, Hengl, Brigita, Gissler, Mika, Gazzelloni, Federica, García-González, Juan Manuel, Freitas, Alberto, Fischer, Florian, Eikemo, Terje Andreas, Dahm, Christina C, Cuschieri, Sarah, Breitner, Susanne, Bølling, Anette Kocbach, Bikbov, Boris, Alkerwi, Ala’A, Ádám, Balázs, Haagsma, Juanita A, Devleesschauwer, Brecht, Sarmiento, Rodrigo, Santi-Cano, María José, Noguer, Isabel, Ngwa, Che Henry, Morgado, Joana Nazaré, Kissimova-Skarbek, Katarzyna, Idavain, Jane, O’Donovan, Mark Ryan, Ortiz, Alberto, Pallari, Elena, Petrou, Panagiotis, Ortiz, Miguel Reina, Riva, Silvia, Samouda, Hanène, Santos, João V, Adi Santoso, Cornelia Melinda, Schmitt, Tugce, Skempes, Dimitrios, Sousa, Ana Catarina, Stevanovic, Aleksandar, Terzic, Gerhard Sulo Natasa, Terzic-Supic, Zorica, Todorovic, Jovana, Tozija, Fimka, Unim, Brigid, Van Wilder, Lisa, Varga, Orsolya, Violante, Francesco S, Wyper, Grant M A, Mevsim, Vildan, Niranjan, Vikram, Ng, Edmond S W, Nena, Evangelia, Mondello, Stefania, Monasta, Lorenzo, Mitchell, Louise, Milicevic, Milena Santric, Repositório da Universidade de Lisboa, and COST Action CA18218

Subjects
Burden of non-communicable diseases, Base de datos bibliográfica, Information Storage and Retrieval, Global Health, Disability-adjusted life years, Europe/epidemiology, Global Burden of Disease, Chronic diseases -- Risk factors -- Europe, SDG 3 - Good Health and Well-being, Medicine and Health Sciences, Humans, Non-communicable diseases, ddc:610, Noncommunicable Diseases, Cost of illness -- Europe, Disability-adjusted life years -- Europe, Public Health, Environmental and Occupational Health, Burden of disease, Noncommunicable Diseases/epidemiology, Burden of Disease methodology, Europe, European Burden of Disease Network, Enfermedades no transmisibles, Global burden of disease -- Europe, Medical care, Cost of -- Europe -- Case studies, Quality-Adjusted Life Years, non-communicable disease studies, 610 Medizin und Gesundheit
Abstract

Background: Assessment of disability-adjusted life years (DALYs) resulting from non-communicable diseases (NCDs) requires specific calculation methods and input data. The aims of this study were to (i) identify existing NCD burden of disease (BoD) activities in Europe; (ii) collate information on data sources for mortality and morbidity; and (iii) provide an overview of NCD-specific methods for calculating NCD DALYs. Methods: NCD BoD studies were systematically searched in international electronic literature databases and in grey literature. We included all BoD studies that used the DALY metric to quantify the health impact of one or more NCDs in countries belonging to the European Region. Results: A total of 163 BoD studies were retained: 96 (59%) were single-country or sub-national studies and 67 (41%) considered more than one country. Of the single-country studies, 29 (30%) consisted of secondary analyses using existing Global Burden of Disease (GBD) results. Mortality data were mainly derived (49%) from vital statistics. Morbidity data were frequently (40%) drawn from routine administrative and survey datasets, including disease registries and hospital discharge databases. The majority (60%) of national BoD studies reported mortality corrections. Multimorbidity adjustments were performed in 18% of national BoD studies. Conclusion: The number of national NCD BoD assessments across Europe increased over time, driven by an increase in BoD studies that consisted of secondary data analysis of GBD study findings. Ambiguity in reporting the use of NCD-specific BoD methods underlines the need for reporting guidelines of BoD studies to enhance the transparency of NCD BoD estimates across Europe., peer-reviewed

Published
2022

18. Methodological considerations in injury burden of disease studies across Europe: a systematic literature review

Author

Charalampous, Periklis, Pallari, Elena, Gorasso, Vanessa, von der Lippe, Elena, Devleesschauwer, Brecht, Pires, Sara M, Plass, Dietrich, Idavain, Jane, Ngwa, Che Henry, Noguer, Isabel, Padron- Monedero, Alicia, Sarmiento, Rodrigo, Majdan, Marek, Ádám, Balázs, AlKerwi, Ala’a, Cilovic- Lagarija, Seila, Clarsen, Benjamin, Corso, Barbara, Cuschieri, Sarah, Dopelt, Keren, Economou, Mary, Fischer, Florian, Freitas, Alberto, García-González, Juan Manuel, Gazzelloni, Federica, Gkitakou, Artemis, Gulmez, Hakan, Hynds, Paul, Isola, Gaetano, Jakobsen, Lea S, Kabir, Zubair, Kissimova-Skarbek, Katarzyna, Knudsen, Ann Kristin, Meriç Konar, Naime, Ladeira, Carina, Lassen, Brian, Liew, Aaron, Majer, Marjeta, Mechili, Enkeleint A, Mereke, Alibek, Monasta, Lorenzo, Mondello, Stefania, Morgado, Joana Nazaré, Nena, Evangelia, Ng Edmond S.W., Niranjan, Vikram, Nola, Iskra Alexandra, O’Caoimh, Rónán, Petrou, Panagiotis, Pinheiro, Vera, Ortiz, Miguel Reina, Riva, Silva, Samouda, Hanen, Santos, João Vasco, Santoso, Cornelia Melinda Adi, Santric Milicevic, Milena, Skempes, Dimitrios, Sousa, Ana Catarina, Speybroeck, Niko, Tozija, Fimka, Unim, Brigid, Uysal, Hilal Bektaş, Vaccaro, Fabrizio Giovanni, Varga, Orsolya, Vasic, Milena, Violante, Francesco Saverio, Wyper, Grant M. A., Polinder, Suzzane, Haagsma, Juanita A., No funding was received for this study, Tıp Fakültesi, Naime Meriç Konar / 0000-0002-6593-7617, Charalampous P., Pallari E., Gorasso V., von der Lippe E., Devleesschauwer B., Pires S.M., Plass D., Idavain J., Ngwa C.H., Noguer I., Padron-Monedero A., Sarmiento R., Majdan M., Adam B., AlKerwi A., Cilovic-Lagarija S., Clarsen B., Corso B., Cuschieri S., Dopelt K., Economou M., Fischer F., Freitas A., Garcia-Gonzalez J.M., Gazzelloni F., Gkitakou A., Gulmez H., Hynds P., Isola G., Jakobsen L.S., Kabir Z., Kissimova-Skarbek K., Knudsen A.K., Konar N.M., Ladeira C., Lassen B., Liew A., Majer M., Mechili E.A., Mereke A., Monasta L., Mondello S., Morgado J.N., Nena E., Ng E.S.W., Niranjan V., Nola I.A., O'Caoimh R., Petrou P., Pinheiro V., Ortiz M.R., Riva S., Samouda H., Santos J.V., Santoso C.M.A., Milicevic M.S., Skempes D., Sousa A.C., Speybroeck N., Tozija F., Unim B., Uysal H.B., Vaccaro F.G., Varga O., Vasic M., Violante F.S., Wyper G.M.A., Polinder S., Haagsma J.A., and Repositório da Universidade de Lisboa

Subjects
Burden of Injury, Burden of disease, Disability-adjusted life years, Review, Methodology, Disability-adjusted life year, Global Burden of Disease, Carga Global de Enfermedades, Costo de Enfermedad, SDG 3 - Good Health and Well-being, Cost of Illness, HEALTH BURDEN, Medicine and Health Sciences, Humans, Disabled Persons, TRAUMA, Personas con Discapacidad, ADJUSTED LIFE YEARS, MORTALITY, Public Health, Environmental and Occupational Health, Morbilidad, Enfermedades, EVOLUTION, Europe, SERIOUS ROAD INJURIES, SAFETY, Años de Vida Ajustados por Calidad de Vida, DISABILITY WEIGHTS, Quality-Adjusted Life Years, Review Methodology, TRAFFIC ACCIDENTS
Abstract

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data., Background: Calculating the disease burden due to injury is complex, as it requires many methodological choices. Until now, an overview of the methodological design choices that have been made in burden of disease (BoD) studies in injury populations is not available. The aim of this systematic literature review was to identify existing injury BoD studies undertaken across Europe and to comprehensively review the methodological design choices and assumption parameters that have been made to calculate years of life lost (YLL) and years lived with disability (YLD) in these studies. Methods: We searched EMBASE, MEDLINE, Cochrane Central, Google Scholar, and Web of Science, and the grey literature supplemented by handsearching, for BoD studies. We included injury BoD studies that quantified the BoD expressed in YLL, YLD, and disability-adjusted life years (DALY) in countries within the European Region between early-1990 and mid-2021. Results: We retrieved 2,914 results of which 48 performed an injury-specific BoD assessment. Single-country independent and Global Burden of Disease (GBD)-linked injury BoD studies were performed in 11 European countries. Approximately 79% of injury BoD studies reported the BoD by external cause-of-injury. Most independent studies used the incidence-based approach to calculate YLDs. About half of the injury disease burden studies applied disability weights (DWs) developed by the GBD study. Almost all independent injury studies have determined YLL using national life tables. Conclusions: Considerable methodological variation across independent injury BoD assessments was observed; differences were mainly apparent in the design choices and assumption parameters towards injury YLD calculations, implementation of DWs, and the choice of life table for YLL calculations. Development and use of guidelines for performing and reporting of injury BoD studies is crucial to enhance transparency and comparability of injury BoD estimates across Europe and beyond.

Published
2022

19. The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study.

Author

Haagsma, Juanita A., Charalampous, Periklis, Ariani, Filippo, Gallay, Anne, Moesgaard Iburg, Kim, Nena, Evangelia, Ngwa, Che Henry, Rommel, Alexander, Zelviene, Ausra, Abegaz, Kedir Hussein, Al Hamad, Hanadi, Albano, Luciana, Liliana Andrei, Catalina, Andrei, Tudorel, Antonazzo, Ippazio Cosimo, Aremu, Olatunde, Arumugam, Ashokan, Atreya, Alok, Aujayeb, Avinash, and Ayuso-Mateos, Jose Luis

Subjects
GLOBAL burden of disease, WOUNDS & injuries
Abstract

Background: Injury remains a major concern to public health in the European region. Previous iterations of the Global Burden of Disease (GBD) study showed wide variation in injury death and disability adjusted life year (DALY) rates across Europe, indicating injury inequality gaps between sub-regions and countries. The objectives of this study were to: 1) compare GBD 2019 estimates on injury mortality and DALYs across European sub-regions and countries by cause-of-injury category and sex; 2) examine changes in injury DALY rates over a 20 year-period by cause-of-injury category, sub-region and country; and 3) assess inequalities in injury mortality and DALY rates across the countries. Methods: We performed a secondary database descriptive study using the GBD 2019 results on injuries in 44 European countries from 2000 to 2019. Inequality in DALY rates between these countries was assessed by calculating the DALY rate ratio between the highest-ranking country and lowest-ranking country in each year. Results: In 2019, in Eastern Europe 80 [95% uncertainty interval (UI): 71 to 89] people per 100,000 died from injuries; twice as high compared to Central Europe (38 injury deaths per 100,000; 95% UI 34 to 42) and three times as high compared to Western Europe (27 injury deaths per 100,000; 95%UI 25 to 28). The injury DALY rates showed less pronounced differences between Eastern (5129 DALYs per 100,000; 95% UI: 4547 to 5864), Central (2940 DALYs per 100,000; 95% UI: 2452 to 3546) and Western Europe (1782 DALYs per 100,000; 95% UI: 1523 to 2115). Injury DALY rate was lowest in Italy (1489 DALYs per 100,000) and highest in Ukraine (5553 DALYs per 100,000). The difference in injury DALY rates by country was larger for males compared to females. The DALY rate ratio was highest in 2005, with DALY rate in the lowest-ranking country (Russian Federation) 6.0 times higher compared to the highest-ranking country (Malta). After 2005, the DALY rate ratio between the lowest- and the highest-ranking country gradually decreased to 3.7 in 2019. Conclusions: Injury mortality and DALY rates were highest in Eastern Europe and lowest in Western Europe, although differences in injury DALY rates declined rapidly, particularly in the past decade. The injury DALY rate ratio of highest- and lowest-ranking country declined from 2005 onwards, indicating declining inequalities in injuries between European countries. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author

Roth, Gregory A., Collaborotors, G. B. D.Causes Death, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M., Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Load, Abdela, Jemal, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abejie, Ayenew Negesse, Abera, Semaw F., Abil, Olifan Zewdie, Abraha, Haftom Niguse, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adamu, Abdu A., Adebayo, Oladimeji, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Adookunboh, Olatunii, Adhena, Beyene Meressa, Adib, Mina G., Admasie, Aniha, Afshin, Ashkan, Agarwal, Gina, Agesa, Karelia M., Agrawal, Anurag, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Melidi, Ahmed, Muktar Beshir, Ahmed, Sayent, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Fddine, Akbari, Mohammad Esmaeil, Akinyeniti, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Al-Eyadhy, Ayman, Al-Raddadi, Rajaa M., Alandab, Fares, Alam, Khurshid, Alam, Tahiya, Alebel, Animut, Alene, Kefyalew Addis, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alonso, Jordi, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T., Aminde, Leopold N., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampern, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Ansari, Hossein, Aniha, Mustafa Geleto, Antonio, Carl Abelardo T., Anwari, Palwasha, Aremu, Olatunde, Arnlov, Johan, Arora, Amit, Arora, Monika, Artaman, Al, Aryal, Krishna K., Asayesh, Hamid, Asfaw, Ephremi Tsegay, Ataro, Zerihun, Atique, Suleman, Atre, Sachin R., Ausloos, Marcel, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Quintattilla, Beatriz Paulina Ayala, Ayele, Yohanes, Ayer, Rakesh, Azzopardi, Peter S., Babazadeh, Arefeh, Bacha, Umar, Badali, Hamid, Badawi, Alaa, Bali, Ayele Geleto, Ballesteros, Katherine E., Banach, Maciej, Banerjee, Kajori, Bannick, Marlena S., Banoub, Joseph Adel Mattar, Barboza, Miguel A., Barker-Collo, Suzanne Lyu, Barnighausen, Till Winfried, Barquera, Simon, Barrero, Lope, Bassat, Quique, Base, Sanjay, Baune, Bernhard T., Baynes, Habtamu Wondifraw, Bazargan-Hejazi, Shahrzad, Beth, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Mcysam, Bejot, Yannick, Bekele, Bayu Begashaw, Belacliew, Abate Bekele, Belay, Ezra, Belay, Yihalem Abebe, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berman, Adam F., Bernabe, Eduardo, Bernstein, Robert S., Bertolacci, Gregory J., Beuran, Mircea, Beyranvand, Tina, Bhalla, Ashish, Bhattarai, Suraj, Bhaumik, Sounayadeeep, Bhutta, Zulfiqar A., Biadgo, Belete, Biehl, Molly H., Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bililign, Nigus, Bin Sayeed, Muhammad Shandaat, Bisanzio, Donal, Biswas, Tuhin, Blacker, Brigitte F., Basara, Berrak Bora, Borschmann, Rohan, Bosetti, Cristina, Bozorgmehr, Kayvan, Brady, Oliver J., Brant, Luisa C., Brayne, Carol, Brazinova, Alexandra, Breitborde, Nicholas J. 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Dean, Hosseini, Seyed Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian C., Hsiao, Thomas, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hussen, Mohammedaman Mama, Hutfless, Susan, Idrisov, Bulat, Ilesanmi, Olayinka Stephen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, Nazrul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Jacobsen, Kathryn H., Jahangiry, Leila, Jahanmehr, Nader, Jain, Sudhir Kumar, Jakovlievic, Mihajlo, Jalu, Moti Tolera, James, Spencer L., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jenkins, Kathy J., Jha, Ravi Prakash, Jha, Vivekanand, Johnson, Catherine O., Johnson, Sarah C., Jonas, Jost B., Joshi, Ankur, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jurisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalani, Rizwan, Karami, Manoochehr, Matin, Behzad Karami, Karch, Andre, Karema, Corine, Karimi-Sari, Hamidreza, Kasaeian, Amir, Kassa, Dessalegn H., Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kaul, Anil, Kazemi, Zhila, Karyani, Ali Kazemi, Kazi, Dhruv Satish, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khafaei, Behzad, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalid, Nauman, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Khan, Muhammad Ali, Khang, Young-Ho, Khater, Mona M., Khoja, Abdullah T., Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kiadaliri, Aliasghar A., Kibret, Getiye D., Kidanemariam, Zelalem Teklemariam, Kiirithio, Daniel N., Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimaki, Mika, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Kokubo, Yoshihiro, Kolola, Tufa, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael A., Krishan, Kewal, Defo, Barthelemy Kuate, Bicer, Burcu Kinuk, Kumar, G. Anil, Kumar, Manasi, Kumar, Pushpendra, Kutz, Michael J., Kuzin, Igor, Kyu, Hmwe Hmwe, Lad, Deepesh P., Lad, Sheetal D., Lafranconi, Alessandra, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lam, Jennifer O., Lami, Faris Hasan, Van Lansingh, C., Lansky, Sonia, Larson, Heidi J., Latifi, Amman, Lau, Kathryn Mei-Ming, Lazarus, Jeffrey V., Lebedev, Georgy, Lee, Paul H., Leigh, James, Leili, Mostafa, Leshargie, Cheru Tesema, Li, Shanshan, Li, Yichong, Liang, Juan, Lim, Lee-Ling, Lim, Stephen S., Limenih, Miteku Andualem, Linn, Shai, Liu, Shiwei, Liu, Yang, Lodha, Rakesh, Lansdale, Chris, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Ma, Stefan, Macarayan, Erlyn Rachelle King, Mackay, Mark T., MacLachlan, Jennifer H., Maddison, Emilie R., Nadotto, Fabiana, Abd El Razek, Hassan Magdy, Abd El Razek, Muhammed Magdy, Maghavani, Dhaval P., Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manda, Ana-Laura, Mandarano-Filho, Luiz Garcia, Manguerra, Helena, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Maravilla, Joemer C., Marcenes, Wagner, Marczak, Laurie, Marks, Ashley, Marks, Guy B., Martinez, Gabriel, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, Marz, Winfried, Marron, Melvin B., Masci, Joseph R., Lylassenburg, Benjamin Ballard, Mathur, Manu Raj, Mathur, Prashant, Matzopoulos, Richard, Maulik, Pallab K., Mazidi, Mohsen, McAlinden, Cohn, McGrath, John J., McKee, Martin, McMahon, Brian J., Mehata, Suiiesh, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehta, Kala M., Mehta, Varshil, Mekonnen, Tefera C., Melese, Addisu, Melku, Mulugeta, Memiah, Peter T. 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Reiner, Rc, Reitsma, Mb, Renzaho, Amn, Riahi, Sm, Ribeiro, Alp, Rios-Blancas, Mj, Roba, Kt, Roberts, Nl, Robinson, Sr, Sahraian, Ma, Saldanha, Rf, Sambala, Ez, Samy, Am, Sanchez-Niño, Md, Santomauro, Df, Santos, Jv, Milicevic, Mm, Sao Jose, Bp, Sarker, Ar, Sarmiento-Suárez, R, Sawant, Ar, Schmidt, Mi, Schneider, Ijc, Schöttker, B, Schutte, Ae, Schwebel, Dc, Scott, Jg, Sepanlou, Sg, Serván-Mori, E, Shackelford, Ka, Shaheen, Aa, Shaikh, Ma, Shrime, Mg, Siddiqi, Tj, Sigfusdottir, Id, Silberberg, Dh, Silva, Da, Silva, Jp, Silva, Ntd, Silveira, Dga, Singh, Ja, Singh, Np, Singh, Pk, Sinha, Dn, Sobaih, Bh, Sorensen, Rjd, Soriano, Jb, Soyiri, In, Sposato, La, Sreeramareddy, Ct, Stanaway, Jd, Starodubov, Vi, Stein, Dj, Stewart, Lg, Stokes, Ma, Subart, Ml, Sufiyan, Mb, Sur, Pj, Sykes, Bl, Sylaja, Pn, Sylte, Do, Szoeke, Cei, Tabarés-Seisdedos, R, Tadakamadla, Sk, Tassew, Sg, Tekalign, Tg, Tekle, Mg, Temsah, Mh, Teshale, My, Tessema, Ga, Thankappan, Kr, Thrift, Ag, Thurston, Gd, To, Qg, Torre, Ae, Tortajada-Girbés, M, Tovani-Palone, Mr, Tran, Bx, Tran, Kb, Troeger, Ce, Truelsen, Tc, Truong, Nt, Tsadik, Ag, Tuzcu, Em, Ukwaja, Kn, Undurraga, Ea, Updike, Rl, Uthman, Oa, Uzun, Sb, Valdez, Pr, Vasankari, Tj, Vladimirov, Sk, Vollset, Se, Wagner, Gr, Wallin, Mt, Walson, Jl, Wang, Yp, Wassie, Mm, Weintraub, Rg, Weldegwergs, Kg, Werkneh, Aa, West, Te, Whiteford, Ha, Wilner, Lb, Wolfe, Cda, Wu, Yc, Wyper, Gma, Yahyazadeh Jabbari, Sh, Yan, Ll, Yasin, Yj, Yentür, Gk, Yimer, Em, Yirsaw, Bd, Yoon, Sj, Younis, Mz, Zaman, Sb, Zeleke, Aj, Zenebe, Zm, Zhang, Al, Zuhlke, Lj, and Murray, Cjl.

Subjects
Adult, Male, Adolescent, national age-sex-specific mortality, UNITED-STATES, Global Health, Socioeconomic Factor, Global Burden of Disease, GBD, causes of death, Young Adult, Age Distribution, Life Expectancy, General & Internal Medicine, Cause of Death, PUBLIC-HEALTH PROBLEM, mortality, 282 causes global burden of disease, Sex Distribution, Child, Aged, Aged, 80 and over, BARRIERS, DEMENTIA, Medicine (all), Infant, Newborn, Infant, 11 Medical And Health Sciences, Middle Aged, TRENDS, PREVENTION, PREVALENCE, ALZHEIMERS-DISEASE, INDIVIDUALS, 3121 General medicine, internal medicine and other clinical medicine, Child, Preschool, REGISTRATION, Female, Human medicine, Human
Abstract

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. Methods The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODErn), to generate cause fractions and cause specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised. Findings At the broadest grouping of causes of death (Level 1), non-communicable diseases (NC Ds) comprised the greatest fraction of deaths, contributing to 73.4% (95% uncertainty interval [UI] 72.5-74.1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional (CMNN) causes accounted for 186% (17.9-19.6), and injuries 8.0% (7.7-8.2). Total numbers of deaths from NCD causes increased from 2007 to 2017 by 22.7% (21.5-23.9), representing an additional 7.61 million (7. 20-8.01) deaths estimated in 2017 versus 2007. The death rate from NCDs decreased globally by 7.9% (7.08.8). The number of deaths for CMNN causes decreased by 222% (20.0-24.0) and the death rate by 31.8% (30.1-33.3). Total deaths from injuries increased by 2.3% (0-5-4-0) between 2007 and 2017, and the death rate from injuries decreased by 13.7% (12.2-15.1) to 57.9 deaths (55.9-59.2) per 100 000 in 2017. Deaths from substance use disorders also increased, rising from 284 000 deaths (268 000-289 000) globally in 2007 to 352 000 (334 000-363 000) in 2017. Between 2007 and 2017, total deaths from conflict and terrorism increased by 118.0% (88.8-148.6). A greater reduction in total deaths and death rates was observed for some CMNN causes among children younger than 5 years than for older adults, such as a 36.4% (32.2-40.6) reduction in deaths from lower respiratory infections for children younger than 5 years compared with a 33.6% (31.2-36.1) increase in adults older than 70 years. Globally, the number of deaths was greater for men than for women at most ages in 2017, except at ages older than 85 years. Trends in global YLLs reflect an epidemiological transition, with decreases in total YLLs from enteric infections, respirator}, infections and tuberculosis, and maternal and neonatal disorders between 1990 and 2017; these were generally greater in magnitude at the lowest levels of the Socio-demographic Index (SDI). At the same time, there were large increases in YLLs from neoplasms and cardiovascular diseases. YLL rates decreased across the five leading Level 2 causes in all SDI quintiles. The leading causes of YLLs in 1990 neonatal disorders, lower respiratory infections, and diarrhoeal diseases were ranked second, fourth, and fifth, in 2017. Meanwhile, estimated YLLs increased for ischaemic heart disease (ranked first in 2017) and stroke (ranked third), even though YLL rates decreased. Population growth contributed to increased total deaths across the 20 leading Level 2 causes of mortality between 2007 and 2017. Decreases in the cause-specific mortality rate reduced the effect of population growth for all but three causes: substance use disorders, neurological disorders, and skin and subcutaneous diseases. Interpretation Improvements in global health have been unevenly distributed among populations. Deaths due to injuries, substance use disorders, armed conflict and terrorism, neoplasms, and cardiovascular disease are expanding threats to global health. For causes of death such as lower respiratory and enteric infections, more rapid progress occurred for children than for the oldest adults, and there is continuing disparity in mortality rates by sex across age groups. Reductions in the death rate of some common diseases are themselves slowing or have ceased, primarily for NCDs, and the death rate for selected causes has increased in the past decade. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.

Published
2018

21. Burden of non-communicable disease studies in Europe: a systematic review of data sources and methodological choices.

Author

Charalampous, Periklis, Gorasso, Vanessa, Plass, Dietrich, Pires, Sara M, von der Lippe, Elena, Mereke, Alibek, Idavain, Jane, Kissimova-Skarbek, Katarzyna, Morgado, Joana Nazaré, Ngwa, Che Henry, Noguer, Isabel, Padron-Monedero, Alicia, Santi-Cano, María José, Sarmiento, Rodrigo, Devleesschauwer, Brecht, Haagsma, Juanita A, and Participants, The COST Action CA18218

Subjects
NON-communicable diseases, LIFE expectancy, SYSTEMATIC reviews, GLOBAL burden of disease, DISEASES, PEOPLE with disabilities, GREY literature
Abstract

Background Assessment of disability-adjusted life years (DALYs) resulting from non-communicable diseases (NCDs) requires specific calculation methods and input data. The aims of this study were to (i) identify existing NCD burden of disease (BoD) activities in Europe; (ii) collate information on data sources for mortality and morbidity; and (iii) provide an overview of NCD-specific methods for calculating NCD DALYs. Methods NCD BoD studies were systematically searched in international electronic literature databases and in grey literature. We included all BoD studies that used the DALY metric to quantify the health impact of one or more NCDs in countries belonging to the European Region. Results A total of 163 BoD studies were retained: 96 (59%) were single-country or sub-national studies and 67 (41%) considered more than one country. Of the single-country studies, 29 (30%) consisted of secondary analyses using existing Global Burden of Disease (GBD) results. Mortality data were mainly derived (49%) from vital statistics. Morbidity data were frequently (40%) drawn from routine administrative and survey datasets, including disease registries and hospital discharge databases. The majority (60%) of national BoD studies reported mortality corrections. Multimorbidity adjustments were performed in 18% of national BoD studies. Conclusion The number of national NCD BoD assessments across Europe increased over time, driven by an increase in BoD studies that consisted of secondary data analysis of GBD study findings. Ambiguity in reporting the use of NCD-specific BoD methods underlines the need for reporting guidelines of BoD studies to enhance the transparency of NCD BoD estimates across Europe. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017

Author

Murray, Christopher J L, Callender, Charlton S K H, Kulikoff, Xie Rachel, Srinivasan, Vinay, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M, Abbasi, Nooshin, Abbastabar, Hedayat, Abdela, Jemal, Abdelalim, Ahmed, Abdel-Rahman, Omar, Abdi, Alireza, Abdoli, Nasrin, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abebo, Teshome Abuka, Abejie, Ayenew Negesse, Aboyans, Victor, Abraha, Haftom Niguse, Abreu, Daisy Maria Xavier, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen M E, Accrombessi, Manfred Mario Kokou, Acharya, Pawan, Adamu, Abdu A, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Adhikari, Tara Ballav, Adib, Mina G, Adou, Arsène Kouablan, Adsuar, Jose C, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agesa, Kareha M, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmed, Muktar Beshir, Ahmed, Sayem, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akanda, Ali S, Akbari, Mohammad Esmaeil, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akseer, Nadia, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alebel, Animut, Aleman, Alicia V, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Raghib, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Almasi, Ali, Alonso, Jordi, Al-Raddadi, Rajaa M, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ammar, Walid, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Appiah, Seth Christopher Yaw, Aremu, Olatunde, Areri, Habtamu Abera, Arian, Nicholas, Ärnlöv, Johan, Artaman, Al, Aryal, Krishna K, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Asgedom, Solomon Weldegebreal, Assadi, Reza, Atey, Tesfay Mehari Mehari, Atique, Suleman, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avokpaho, Euripide F G A, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayele, Yohanes, Ayer, Rakesh, Ayuk, Tambe B, Azzopardi, Peter S, Babalola, Tesleem Kayode, Babazadeh, Arefeh, Badali, Hamid, Badawi, Alaa, Bali, Ayele Geleto, Banach, Maciej, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Basaleem, Huda, Bassat, Quique, Basu, Arindam, Baune, Bernhard T, Baynes, Habtamu Wondifraw, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Belay, Aregawi Gebreyesus, Belay, Ezra, Belay, Saba Abraham, Belay, Yihalem Abebe, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Bergeron, Gilles, Berhane, Adugnaw, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bertolacci, Gregory J, Beuran, Mircea, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Birlik, Sait Mentes, Birungi, Charles, Biswas, Tuhin, Bizuneh, Hailemichael, Bleyer, Archie, Basara, Berrak Bora, Bosetti, Cristina, Boufous, Soufiane, Brady, Oliver J, Bragazzi, Nicola Luigi, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Brewer, Jerry D, Briant, Paul Svitil, Britton, Gabrielle, Burstein, Roy, Busse, Reinhard, Butt, Zahid A, Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cano, Jorge, Car, Mate, Cárdenas, Rosario, Carrero, Juan J, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castillo Rivas, Jacqueline, Castro, Franz, Catalá-López, Ferrán, Çavlin, Alanur, Cerin, Ester, Chalek, Julian, Chang, Hsing-Yi, Chang, Jung-Chen, Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chiang, Peggy Pei-Chia, Chin, Ken Lee, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal, Choi, Jee-Young J, Chowdhury, Rajiv, Christopher, Devasahayam J, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Claro, Rafael M, Collado-Mateo, 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F, Marzan, M, Mashamba-Thompson, T, Mason-Jones, A, Massenburg, B, Mathur, M, Maulik, P, Mcgrath, J, Mehendale, S, Mehndiratta, M, Mehta, K, Mekonnen, T, Meles, H, Meles, K, Memiah, P, Memish, Z, Mengesha, M, Mengistu, D, Mensah, G, Mereta, S, Meretoja, T, Mezgebe, H, Miller, T, Miller-Petrie, M, Mini, G, Mirrakhimov, E, Misganaw, A, Mohammad, K, Mohammed, M, Mokdad, A, Mola, G, Montañez, J, Morrison, S, Moschos, M, Mousavi, S, Muche, A, Muchie, K, Mueller, U, Murphy, T, Murthy, G, Musa, K, Nachega, J, Nansseu, J, Nascimento, B, Ncama, B, Negoi, R, Newton, C, Ngalesoni, F, Ngunjiri, J, Nguyen, L, Nguyen, T, Ningrum, D, Nirayo, Y, Nisar, M, Nixon, M, Noubiap, J, Nouri, H, Shiadeh, M, Nowroozi, M, Odell, C, Ogbo, F, Oh, I, Olagunju, A, Olagunju, T, Olivares, P, Olusanya, B, Olusanya, J, Ong, S, Otieno, B, Owolabi, M, Pakhare, A, Panda, B, Pandey, A, Park, E, Patil, S, Patton, G, Paturi, V, Pedroso, M, Peprah, E, Pereira, D, Petri, W, Pigott, D, Pillay, J, Polanczyk, G, Postma, M, Purcell, C, Purwar, M, Rahman, S, Rai, R, Ranabhat, C, Rawaf, D, Ray, S, Reiner, R, Renzaho, A, Riahi, S, Rios-Blancas, M, Roba, K, Roberts, N, Ruhago, G, Sabde, Y, Sahraian, M, Saldanha, R, Salomon, J, Sambala, E, Samy, A, Sanchez-Niño, M, Santric Milicevic, M, Sao Jose, B, Sarker, A, Sawant, A, Schneider, I, Schwebel, D, Sepanlou, S, Shackelford, K, Shaheen, A, Shaikh, M, Shakir, R, Shukla, S, Sibai, A, Siddiqi, T, Sigfusdottir, I, Silva, D, Silva, J, Silveira, D, Singam, N, Singh, J, Singh, N, Sinha, D, Soares Filho, A, Sobaih, B, Soriano, J, Soyiri, I, Sreeramareddy, C, Starodubov, V, Stewart, L, Stokes, M, Subart, M, Sufiyan, M, Sunguya, B, Sur, P, Sykes, B, Sylaja, P, Sylte, D, Szoeke, C, Tabb, K, Tadakamadla, S, Tassew, A, Tassew, S, Tawye, N, Tekalign, T, Tekle, M, Temsah, M, Teshale, M, Thankappan, K, Thomson, A, To, Q, Torre, A, Tovani-Palone, M, Tran, B, Tran, K, Tripathy, S, Truelsen, T, Truong, N, Tsadik, A, Ukwaja, K, Uthman, O, Uzun, S, Valdez, P, Vasankari, T, Vasconcelos, A, Vladimirov, S, Vollset, S, Walson, J, Weintraub, R, Weldegwergs, K, Wolfe, C, Wyper, G, Yasin, Y, Yentür, G, Yimer, E, Yoon, S, Younis, M, Zaman, S, Zeleke, M, Zenebe, Z, Zerfu, T, Zhao, X, Zimsen, S, Lopez, A, and Lim, S

Subjects
Adult, Male, Population Density, GBD, population, fertility, Adolescent, Medicine (all), Infant, Newborn, Infant, 11 Medical And Health Sciences, Middle Aged, Global Health, Global Burden of Disease, Young Adult, Child, Preschool, General & Internal Medicine, Female, Human medicine, Mortality, Child, Population Growth, Birth Rate, Aged, Human, Maternal Age
Abstract

Background Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods. Methods We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on the demographic balancing equation, with inputs of fertility, mortality, population, and migration data. Fertility data came from 7817 location-years of vital registration data, 429 surveys reporting complete birth histories, and 977 surveys and censuses reporting summary birth histories. We estimated age-specific fertility rates (ASFRs; the annual number of livebirths to women of a specified age group per 1000 women in that age group) by use of spatiotemporal Gaussian process regression and used the ASFRs to estimate total fertility rates (TFRs; the average number of children a woman would bear if she survived through the end of the reproductive age span [age 10-54 years] and experienced at each age a particular set of ASFRs observed in the year of interest). Because of sparse data, fertility at ages 10-14 years and 50-54 years was estimated from data on fertility in women aged 15-19 years and 45-49 years, through use of linear regression. Age-specific mortality data came from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 estimates. Data on population came from 1257 censuses and 761 population registry location-years and were adjusted for underenumeration and age misreporting with standard demographic methods. Migration was estimated with the GBD Bayesian demographic balancing model, after incorporating information about refugee migration into the model prior. Final population estimates used the cohort-cotnponent method of population projection, with inputs of fertility, mortality, and migration data. Population uncertainty was estimated by use of out-of-sample predictive validity testing. With these data, we estimated the trends in population by age and sex and in fertility by age between 1950 and 2017 in 195 countries and territories. Findings From 1950 to 2017, TFRs decreased by 49.4% (95% uncertainty interval [UI] 46.4-52.0). The TFR decreased from 4.7 livebirths (4.5-4.9) to 2.4 livebirths (2.2-2.5), and the ASFR of mothers aged 10-19 years decreased from 37 livebirths (34-40) to 22 livebirths (19-24) per 1000 women. Despite reductions in the TFR, the global population has been increasing by an average of 83.8 million people per year since 1985. The global population increased by 197-2% (193.3-200.8) since 1950, from 2.6 billion (2.5-2.6) to 7.6 billion (7.4-7.9) people in 2017; much of this increase was in the proportion of the global population in south Asia and sub-Saharan Africa. The global annual rate of population growth increased between 1950 and 1964, when it peaked at 2.0%; this rate then remained nearly constant until 1970 and then decreased to 1.1% in 2017. Population growth rates in the southeast Asia, east Asia, and Oceania GBD super-region decreased from 2.5% in 1963 to O7% in 2017, whereas in sub-Saharan Africa, population growth rates were almost at the highest reported levels ever in 2017, when they were at 2.7%. The global average age increased from 26.6 years in 1950 to 32.1 years in 2017, and the proportion of the population that is of working age (age 15-64 years) increased from 59.9% to 65.3%. At the national level, the TFR decreased in all countries and territories between 1950 and 2017; in 2017, TFRs ranged from a low of 1.0 livebirths (95% UI 0. 9-1.2) in Cyprus to a high of 7.1 livebirths (6.8-7.4) in Niger. The TFR under age 25 years (TFU25; number of livebirths expected by age 25 years for a hypothetical woman who survived the age group and was exposed to current ASFRs) in 2017 ranged from 0.08 livebirths (0.07-0.09) in South Korea to 2.4 livebirths (2.2-2.6) in Niger, and the TFR over age 30 years (I F030; number of livebirths expected for a hypothetical woman ageing from 30 to 54 years who survived the age group and was exposed to current ASFRs) ranged from a low of 0.3 livebirths (0.3-0-4) in Puerto Rico to a high of 3.1 livebirths (3.0-3.2) in Niger. TF030 was higher than TFU25 in 145 countries and territories in 2017.33 countries had a negative population growth rate from 2010 to 2017, most of which were located in central, eastern, and western Europe, whereas population growth rates of more than 2.0% were seen in 33 of 46 countries in sub-Saharan Africa. In 2017, less than 65% of the national population was of working age in 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. Interpretation Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global population continues to grow as mortality declines, with diverse patterns at the national level and across age groups. To our knowledge, this is the first study to provide transparent and replicable estimates of population and fertility, which can be used to inform decision making and to monitor progress. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.

Published
2018

23. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Author

James, Spencer L., Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M., Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Zegeye, Abera, Semaw F., Abil, Olifan Zewdie, Abraha, Haftom Niguse, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen M. E., Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Acharya, Pawan, Ackerman, Ilana N., Adamu, Abdu A., Adebayo, Oladimeji M., Adekanmbi, Victor, Adetokunboh, Olatunji O., Adib, Mina G., Adsuar, Jose C., Afanvi, Kossivi Agbelenko, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agesa, Kareha M., Aggarwal, Rakesh, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akinyemiju, Tomi, Akseer, Nadia, Al-Aly, Ziyad, Al-Eyadhy, Ayman, Al-Mekhlafi, Hesham M., Al-Raddadi, Rajaa M., Alahdab, Fares, Alam, Khurshid, Alam, Tahiya, Alashi, Alaa, Alavian, Seyed Moayed, Alene, Kefyalew Addis, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Alouani, Mohamed M. L., Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T., Aminde, Leopold N., Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T., Anwari, Palwasha, Arabloo, Jalal, Arauz, Antonio, Aremu, Olatunde, Ariani, Filippo, Armoon, Bahroom, Ärnlöv, Johan, Arora, Amit, Artaman, Al, Aryal, Krishna K., Asayesh, Hamid, Asghar, Rana Jawad, Ataro, Zerihun, Atre, Sachin R., Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayer, Rakesh, Azzopardi, Peter S., Babazadeh, Arefeh, Badali, Hamid, Badawi, Alaa, Bali, Ayele Geleto, Ballesteros, Katherine E., Ballew, Shoshana H., Banach, Maciej, Banoub, Joseph Adel Mattar, Banstola, Amrit, Barac, Aleksandra, Barboza, Miguel A., Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H., Baune, Bernhard T., Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, Béjot, Yannick, Belachew, Abate Bekele, Belay, Yihalem Abebe, Bell, Michelle L., Bello, Aminu K., Bensenor, Isabela M., Bernabe, Eduardo, Bernstein, Robert S., Beuran, Mircea, Beyranvand, Tina, Bhala, Neeraj, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A., Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Bisanzio, Donal, Blacker, Brigette F., Blyth, Fiona M., Bou-Orm, Ibrahim R., Boufous, Soufiane, Bourne, Rupert, Brady, Oliver J., Brainin, Michael, Brant, Luisa C., Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Briant, Paul Svitil, Briggs, Andrew M., Briko, Andrey Nikolaevich, Britton, Gabrielle, Brugha, Traolach, Buchbinder, Rachelle, Busse, Reinhard, Butt, Zahid A., Cahuana-Hurtado, Lucero, Cano, Jorge, Cárdenas, Rosario, Carrero, Juan J., Carter, Austin, Carvalho, Félix, Castañeda-Orjuela, Carlos A., Castillo Rivas, Jacqueline, Castro, Franz, Catalá-López, Ferrán, Cercy, Kelly M., Cerin, Ester, Chaiah, Yazan, Chang, Alex R., Chang, Hsing-Yi, Chang, Jung-Chen, Charlson, Fiona J., Chattopadhyay, Aparajita, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chiang, Peggy Pei-Chia, Chin, Ken Lee, Chitheer, Abdulaal, Choi, Jee-Young J., Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam J., Cicuttini, Flavia M., Ciobanu, Liliana G., Cirillo, Massimo, Claro, Rafael M., Collado-Mateo, Daniel, Cooper, Cyrus, Coresh, Josef, Cortesi, Paolo Angelo, Cortinovis, Monica, Costa, Megan, Cousin, Ewerton, Criqui, Michael H., Cromwell, Elizabeth A., Cross, Marita, Crump, John A., Dadi, Abel Fekadu, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., Daryani, Ahmad, Das Gupta, Rajat, Das Neves, José, Dasa, Tamirat Tesfaye, Davey, Gail, Davis, Adrian C., Davitoiu, Dragos Virgil, De Courten, Barbora, De La Hoz, Fernando Pio, De Leo, Diego, De Neve, Jan-Walter, Degefa, Meaza Girma, Degenhardt, Louisa, Deiparine, Selina, Dellavalle, Robert P., Demoz, Gebre Teklemariam, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C., Dessie, Getenet Ayalew, Dey, Subhojit, Dharmaratne, Samath Dhamminda, Dinberu, Mesfin Tadese, Dirac, M. Ashworth, Djalalinia, Shirin, Doan, Linh, Dokova, Klara, Doku, David Teye, Dorsey, E. Ray, Doyle, Kerrie E., Driscoll, Tim Robert, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Duncan, Bruce B., Duraes, Andre R., Ebrahimi, Hedyeh, Ebrahimpour, Soheil, Echko, Michelle Marie, Edvardsson, David, Effiong, Andem, Ehrlich, Joshua R., El Bcheraoui, Charbel, El Sayed Zaki, Maysaa, El-Khatib, Ziad, Elkout, Hajer, Elyazar, Iqbal R. F., Enayati, Ahmadali, Endries, Aman Yesuf, Er, Benjamin, Erskine, Holly E., Eshrati, Babak, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Fakhim, Hamed, Fallah Omrani, Vahid, Faramarzi, Mahbobeh, Fareed, Mohammad, Farhadi, Farzaneh, Farid, Talha A., Farinha, Carla Sofia E. sá, Farioli, Andrea, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fentahun, Netsanet, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, Joao C., Ferrari, Alize J., Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fitzmaurice, Christina, Foigt, Nataliya A., Foreman, Kyle J., Fox, Jack, Frank, Tahvi D., Fukumoto, Takeshi, Fullman, Nancy, Fürst, Thomas, Furtado, João M., Futran, Neal D., Gall, Seana, Ganji, Morsaleh, Gankpe, Fortune Gbetoho, Garcia-Basteiro, Alberto L., Gardner, William M., Gebre, Abadi Kahsu, Gebremedhin, Amanuel Tesfay, Gebremichael, Teklu Gebrehiwo, Gelano, Tilayie Feto, Geleijnse, Johanna M., Genova-Maleras, Ricard, Geramo, Yilma Chisha Dea, Gething, Peter W., Gezae, Kebede Embaye, Ghadiri, Keyghobad, Ghasemi Falavarjani, Khalil, Ghasemi-Kasman, Maryam, Ghimire, Mamata, Ghosh, Rakesh, Ghoshal, Aloke Gopal, Giampaoli, Simona, Gill, Paramjit Singh, Gill, Tiffany K., Ginawi, Ibrahim Abdelmageed, Giussani, Giorgia, Gnedovskaya, Elena V., Goldberg, Ellen M., Goli, Srinivas, Gómez-Dantés, Hector, Gona, Philimon N., Gopalani, Sameer Vali, Gorman, Taren M., Goulart, Alessandra C., Goulart, Bárbara Niegia Garcia, Grada, Ayman, Grams, Morgan E., Grosso, Giuseppe, Gugnani, Harish Chander, Guo, Yuming, Gupta, Prakash C., Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gyawali, Bishal, Haagsma, Juanita A., Hachinski, Vladimir, Hafezi-Nejad, Nima, Haghparast Bidgoli, Hassan, Hagos, Tekleberhan B., Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R., Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hasan, Mehedi, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hawley, Caitlin N., Hay, Roderick J., Hay, Simon I., Hedayatizadeh-Omran, Akbar, Heibati, Behzad, Hendrie, Delia, Henok, Andualem, Herteliu, Claudiu, Heydarpour, Sousan, Hibstu, Desalegn Tsegaw, Hoang, Huong Thanh, Hoek, Hans W., Hoffman, Howard J., Hole, Michael K., Homaie Rad, Enayatollah, Hoogar, Praveen, Hosgood, H. Dean, Hosseini, Seyed Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Huynh, Chantal K., Iburg, Kim Moesgaard, Ikeda, Chad Thomas, Ileanu, Bogdan, Ilesanmi, Olayinka Stephen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Jacobsen, Kathryn H., Jahangiry, Leila, Jahanmehr, Nader, Jain, Sudhir Kumar, Jakovljevic, Mihajlo, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Johnson, Catherine O., Jonas, Jost B., Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalani, Rizwan, Kanchan, Tanuj, Karami, Manoochehr, Karami Matin, Behzad, Karch, André, Karema, Corine, Karimi, Narges, Karimi, Seyed M., Kasaeian, Amir, Kassa, Dessalegn H., Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kawakami, Norito, Karyani, Ali Kazemi, Keighobadi, Masoud Masoud, Keiyoro, Peter Njenga, Kemmer, Laura, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Khader, Yousef Saleh, Khafaei, Behzad, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Khan, Muhammad Ali, Khang, Young-Ho, Khazaei, Mohammad, Khoja, Abdullah T., Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Kiadaliri, Aliasghar A., Kiirithio, Daniel N., Kim, Cho-Il, Kim, Daniel, Kim, Pauline, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Kokubo, Yoshihiro, Kolola, Tufa, Kopec, Jacek A., Kosen, Soewarta, Kotsakis, Georgios A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael A., Krishan, Kewal, Krohn, Kristopher J., Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kumar, G. Anil, Kumar, Manasi, Kyu, Hmwe Hmwe, Lad, Deepesh P., Lad, Sheetal D., Lafranconi, Alessandra, Lalloo, Ratilal, Lallukka, Tea, Lami, Faris Hasan, Lansingh, Van C., Latifi, Arman, Lau, Kathryn Mei-Ming, Lazarus, Jeffrey V., Leasher, Janet L., Ledesma, Jorge R., Lee, Paul H., Leigh, James, Leung, Janni, Levi, Miriam, Lewycka, Sonia, Li, Shanshan, Li, Yichong, Liao, Yu, Liben, Misgan Legesse, Lim, Lee-Ling, Lim, Stephen S., Liu, Shiwei, Lodha, Rakesh, Looker, Katharine J., Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Low, Nicola, Lozano, Rafael, Lucas, Tim C. D., Lucchesi, Lydia R., Lunevicius, Raimundas, Lyons, Ronan A., Ma, Stefan, Macarayan, Erlyn Rachelle King, Mackay, Mark T., Madotto, Fabiana, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Maghavani, Dhaval P., Mahotra, Narayan Bahadur, Mai, Hue Thi, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A., Manda, Ana-Laura, Manguerra, Helena, Manhertz, Treh, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Mapoma, Chabila Christopher, Maravilla, Joemer C., Marcenes, Wagner, Marks, Ashley, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, März, Winfried, Marzan, Melvin B., Mashamba-Thompson, Tivani Phosa, Massenburg, Benjamin Ballard, Mathur, Manu Raj, Matsushita, Kunihiro, Maulik, Pallab K., Mazidi, Mohsen, McAlinden, Colm, McGrath, John J., McKee, Martin, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehta, Kala M., Mehta, Varshil, Mejia-Rodriguez, Fabiola, Mekonen, Tesfa, Melese, Addisu, Melku, Mulugeta, Meltzer, Michele, Memiah, Peter T. 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Subjects
YLDs, global burden of disease, General & Internal Medicine, Medicine (all), prevalence, incidence, Human medicine, global burden of disease, YLDs, incidence, prevalence, GBD, years lived with disability
Abstract

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 39% (95% uncertainty interval [UI] 3.1-4. 6) from 1990 to 2017; however, the all-age YLD rate increased by 7.2% (6.0-8.4) while the total sum of global YLDs increased from 562 million (421-723) to 853 million (642-1100). The increases for males and females were similar, with increases in all-age YLD rates of 7.9% (6 6-9. 2) for males and 6.5% (5.4-7.7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782-3252] per 100 000 in males vs 1400 [1279-1524] per 100 000 in females), transport injuries (3322 [3082-3583] vs 2336 [2154-2535]), and self-hatin and interpersonal violence (3265 [2943-3630] vs 5643 [5057-6302]). Interpretation Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.

Published
2018

24. Global, regional, and national burden of suicide mortality 1990 to 2016:Systematic analysis for the Global Burden of Disease Study 2016

Author

Orpana, Heather M., Marczak, Laurie B., Arora, Megha, Abbasi, Nooshin, Abdulkader, Rizwan Suliankatchi, Abebe, Zegeye, Abraha, Haftom Niguse, Afarideh, Mohsen, Afshari, Mahdi, Ahmadi, Alireza, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akseer, Nadia, Al‐raddadi, Rajaa M., Alahdab, Fares, Alkerwi, Ala'a, Allebeck, Peter, Alvis‐guzman, Nelson, Anber, Nahla Hamed, Anjomshoa, Mina, Antonio, Carl Abelardo T., Arora, Amit, Aryal, Krishna K., Asgedom, Solomon Weldegebreal, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Badali, Hamid, Barker‐collo, Suzanne Lyn, Bärnighausen, Till Winfried, Bazargan‐hejazi, Shahrzad, Benjet, Corina, Bensenor, Isabela M., Berfeld, Noami, Beuran, Mircea, Bhutta, Zulfiqar A., Biadgo, Belete, Bililign, Nigus, Borges, Guilherme, Borschmann, Rohan, Brazinova, Alexandra, Breitborde, Nicholas J.K., Brugha, Traolach, Butt, Zahid A., Carrero, Juan J., Carvalho, Félix, Malta, Deborah Carvalho, Castañeda‐orjuela, Carlos A., Catalá‐lópez, Ferrán, Ciobanu, Liliana G., Dachew, Berihun Assefa, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., Daryani, Ahmad, Davitoiu, Dragos Virgil, Davletov, Kairat, Degenhardt, Louisa, Demoz, Gebre Teklemariam, Jarlais, Don C.Des, Dharmaratne, Samath Dhamminda, Djalalinia, Shirin, Doan, Linh, Doku, David Teye, Dubey, Manisha, El‐khatib, Ziad, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Faro, Andre, Farzadfar, Farshad, Fekadu, Wubalem, Fernandes, Eduarda, Ferrari, Alize J., Filip, Irina, Fischer, Florian, Foreman, Kyle J., Fukumoto, Takeshi, Gebre, Abadi Kahsu, Grosso, Giuseppe, Gupta, Rahul, Haagsma, Juanita A., Bidgoli, Hassan Haghparast, Haj‐mirzaian, Arvin, Hamidi, Samer, Hankey, Graeme J., Haro, Josep Maria, Hassen, Hamid Yimam, Hay, Simon I., Heidari, Behnam, Hendrie, Delia, Rad, Enayatollah Homaie, Hosseini, Seyed Mostafa, Hostiuc, Sorin, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jakovljevic, Mihajlo, James, Spencer, Jayatilleke, Achala Upendra, Jha, Ravi Prakash, Jonas, Jost B., Jozwiak, Jacek Jerzy, Kadel, Rajendra, Kahsay, Amaha, Kasaeian, Amir, Kassa, Getachew Mullu, Kawakami, Norito, Kefale, Adane Teshome, Kemp, Grant Rodgers, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Muhammad Ali, Khan, Muhammad Shahzeb, Khang, Young Ho, Khubchandani, Jagdish, Kiadaliri, Aliasghar A., Kieling, Christian, Kim, Young Eun, Kisa, Adnan, Knudsen, Ann Kristin Skrindo, Kokubo, Yoshihiro, Koyanagi, Ai, Krish, Varsha Sarah, Defo, Barthelemy Kuate, Kumar, G. Anil, Kumar, Manasi, Lamichhane, Prabhat, Lang, Justin J., Latifi, Arman, Lee, Paul H., Leung, Janni, Lim, Lee Ling, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Mahesh, P. A., Majdan, Marek, Majdzadeh, Reza, Malekzadeh, Reza, Manda, Ana Laura, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Maravilla, Joemer C., Martinez‐raga, Jose, Mathur, Manu Raj, Maulik, Pallab K., McGrath, John J., Mehrotra, Ravi, Mekonen, Tesfa, Mendoza, Walter, Meretoja, Tuomo J., Mestrovic, Tomislav, Miller, Ted R., Mini, G. K., Mirrakhimov, Erkin M., Mitchell, Philip B., Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadi, Moslem, Mohammed, Shafiu, Mokdad, Ali H., Monasta, Lorenzo, Moosazadeh, Mahmood, Moradi, Ghobad, Moradi‐lakeh, Maziar, Moradinazar, Mehdi, Velásquez, Ilais Moreno, Morisaki, Naho, Morrison, Shane Douglas, Moschos, Marilita M., Mousavi, Seyyed Meysam, Mustafa, Ghulam, Nagel, Gabriele, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Negoi, Ionut, Negoi, Ruxandra Irina, Nguyen, Huong Lan Thi, Nguyen, Long Hoang, Nixon, Molly R., Ofori‐asenso, Richard, Ogbo, Felix Akpojene, Oh, In Hwan, Olagunju, Andrew T., Olagunju, Tinuke O., Øverland, Simon, Owolabi, Mayowa Ojo, Panda‐jonas, Songhomitra, Parry, Charles D.H., Pati, Sanghamitra, Patten, Scott B., Patton, George C., Petzold, Max, Phillips, Michael R., Plana‐ripoll, Oleguer, Postma, Maarten J., Pourshams, Akram, Poustchi, Hossein, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi‐movaghar, Afarin, Rahimi‐movaghar, Vafa, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Rezaeian, Shahab, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostami, Ali, Sachdev, Perminder S., Safari, Hosein, Safiri, Saeid, Salamati, Payman, Salimi, Yahya, Salomon, Joshua A., Samy, Abdallah M., Santos, Itamar S., Santric‐milicevic, Milena M., Sartorius, Benn, Sarvi, Shahabeddin, Satpathy, Maheswar, Sawhney, Monika, Schwebel, David C., Sepanlou, Sadaf G., Shaikh, Masood Ali, Sharif, Mehdi, Shibuya, Kenji, Shigematsu, Mika, Shiri, Rahman, Shiue, Ivy, Siabani, Soraya, Siddiqi, Tariq J., Sigfusdottir, Inga Dora, Silva, João Pedro, Singh, Jasvinder A., Filho, Adauto Martins Soares, Sobhani, Soheila, Stein, Dan J., Stein, Murray B., Sufiyan, Mu'awiyyah Babale, Sunguya, Bruno F., Tabarés‐seisdedos, Rafael, Tabb, Karen M., Tavakkoli, Mohammad, Tehrani‐banihashemi, Arash, Temsah, Mohamad Hani, Topor‐madry, Roman, Tran, Bach Xuan, Tran, Khanh Bao, Ullah, Irfan, Unutzer, Jurgen, Usman, Muhammad Shariq, Uthman, Olalekan A., Valdez, Pascual R., Yonemoto, Naohiro, Vasconcelos, Cintia, Vlassov, Vasily, Vos, Theo, Vujcic, Isidora S., Waheed, Yasir, Wang, Yuan Pang, Weiderpass, Elisabete, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Wyper, Grant M.A., Yaseri, Mehdi, Yimer, Ebrahim M., Yisma, Engida, Yoon, Seok Jun, Yotebieng, Marcel, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Zamani, Mohammad, Murray, Christopher J.L., Naghavi, Mohsen, Orpana, H, Marczak, L, Arora, M, Abbasi, N, Abdulkader, R, Abebe, Z, Abraha, H, Afarideh, M, Afshari, M, Ahmadi, A, Aichour, A, Aichour, I, Aichour, M, Akseer, N, Al‐raddadi, R, Alahdab, F, Alkerwi, A, Allebeck, P, Alvis‐guzman, N, Anber, N, Anjomshoa, M, Antonio, C, Arora, A, Aryal, K, Asgedom, S, Awasthi, A, Quintanilla, B, Badali, H, Barker‐collo, S, Bärnighausen, T, Bazargan‐hejazi, S, Benjet, C, Bensenor, I, Berfeld, N, Beuran, M, Bhutta, Z, Biadgo, B, Bililign, N, Borges, G, Borschmann, R, Brazinova, A, Breitborde, N, Brugha, T, Butt, Z, Carrero, J, Carvalho, F, Malta, D, Castañeda‐orjuela, C, Catalá‐lópez, F, Ciobanu, L, Dachew, B, Dandona, L, Dandona, R, Dargan, P, Daryani, A, Davitoiu, D, Davletov, K, Degenhardt, L, Demoz, G, Jarlais, D, Dharmaratne, S, Djalalinia, S, Doan, L, Doku, D, Dubey, M, El‐khatib, Z, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Faro, A, Farzadfar, F, Fekadu, W, Fernandes, E, Ferrari, A, Filip, I, Fischer, F, Foreman, K, Fukumoto, T, Gebre, A, Grosso, G, Gupta, R, Haagsma, J, Bidgoli, H, Haj‐mirzaian, A, Hamidi, S, Hankey, G, Haro, J, Hassen, H, Hay, S, Heidari, B, Hendrie, D, Rad, E, Hosseini, S, Hostiuc, S, Irvani, S, Islam, S, Jakovljevic, M, James, S, Jayatilleke, A, Jha, R, Jonas, J, Jozwiak, J, Kadel, R, Kahsay, A, Kasaeian, A, Kassa, G, Kawakami, N, Kefale, A, Kemp, G, Khader, Y, Khafaie, M, Khalil, I, Khan, E, Khan, M, Khang, Y, Khubchandani, J, Kiadaliri, A, Kieling, C, Kim, Y, Kisa, A, Knudsen, A, Kokubo, Y, Koyanagi, A, Krish, V, Defo, B, Kumar, G, Kumar, M, Lamichhane, P, 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Subjects
Suicide Prevention, Adult, Cross-Cultural Comparison, Male, Data Interpretation, Adolescent, Outcome Assessment, Age Distribution, Age Factors, Aged, Cause of Death, Data Interpretation, Statistical, Female, Global Health, Humans, Life Expectancy, Mortality, Outcome Assessment, Health Care, Sex Distribution, Sex Factors, Socioeconomic Factors, Global Burden of Disease, Suicide, Medicine (all), Research, Statistical, Health Care
Abstract

Objectives To use the estimates from the Global Burden of Disease Study 2016 to describe patterns of suicide mortality globally, regionally, and for 195 countries and territories by age, sex, and Socio-demographic index, and to describe temporal trends between 1990 and 2016. Design Systematic analysis. Main outcome measures Crude and age standardised rates from suicide mortality and years of life lost were compared across regions and countries, and by age, sex, and Socio-demographic index (a composite measure of fertility, income, and education). Results The total number of deaths from suicide increased by 6.7% (95% uncertainty interval 0.4% to 15.6%) globally over the 27 year study period to 817 000 (762 000 to 884 000) deaths in 2016. However, the age standardised mortality rate for suicide decreased by 32.7% (27.2% to 36.6%) worldwide between 1990 and 2016, similar to the decline in the global age standardised mortality rate of 30.6%. Suicide was the leading cause of age standardised years of life lost in the Global Burden of Disease region of high income Asia Pacific and was among the top 10 leading causes in eastern Europe, central Europe, western Europe, central Asia, Australasia, southern Latin America, and high income North America. Rates for men were higher than for women across regions, countries, and age groups, except for the 15 to 19 age group. There was variation in the female to male ratio, with higher ratios at lower levels of Socio-demographic index. Women experienced greater decreases in mortality rates (49.0%, 95% uncertainty interval 42.6% to 54.6%) than men (23.8%, 15.6% to 32.7%). Conclusions Age standardised mortality rates for suicide have greatly reduced since 1990, but suicide remains an important contributor to mortality worldwide. Suicide mortality was variable across locations, between sexes, and between age groups. Suicide prevention strategies can be targeted towards vulnerable populations if they are informed by variations in mortality rates.

Published
2019

25. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

James, Spencer L, Theadom, Alice, Ellenbogen, Richard G, Bannick, Marlena S, Mountjoy-Venning, W Cliff, Lucchesi, Lydia R, Abbasi, Nooshin, Abdulkader, Rizwan, Abraha, Haftom Niguse, Adsuar, Jose C, Afarideh, Mohsen, Agrawal, Sutapa, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akinyemi, Rufus Olusola, Akseer, Nadia, Alahdab, Fares, Alebel, Animut, Alghnam, Suliman A, Ali, Beriwan Abdulqadir, Alsharif, Ubai, Altirkawi, Khalid, Andrei, Catalina Liliana, Anjomshoa, Mina, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Appiah, Seth Christopher Yaw, Ariani, Filippo, Asefa, Nigus Gebremedhin, Asgedom, Solomon Weldegebreal, Atique, Suleman, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Ayuk, Tambe B, Azzopardi, Peter S, Badali, Hamid, Badawi, Alaa, Balalla, Shivanthi, Banstola, Amrit, Barker-Collo, Suzanne Lyn, Barnighausen, Till Winfried, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, 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Hibstu D.T., Hoffman H.J., Hole M.K., Homaie Rad E., Hosseini S.M., Hostiuc S., Hu G., Hussen M.A., Ilesanmi O.S., Irvani S.S.N., Jakovljevic M., Jayaraman S., Jha R.P., Jonas J.B., Jones K.M., Jorjoran Shushtari Z., Jozwiak J.J., Jurisson M., Kabir A., Kahsay A., Kahssay M., Kalani R., Karch A., Kasaeian A., Kassa G.M., Kassa T.D., Kassa Z.Y., Kengne A.P., Khader Y.S., Khafaie M.A., Khalid N., Khalil I., Khan E.A., Khan M.S., Khang Y.-H., Khazaie H., Khoja A.T., Khubchandani J., Kiadaliri A.A., Kim D., Kim Y.-E., Kisa A., Koyanagi A., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kumar G.A., Kumar M., Lalloo R., Lami F.H., Lansingh V.C., Laryea D.O., Latifi A., Leshargie C.T., Levi M., Li S., Liben M.L., Lotufo P.A., Lunevicius R., Mahotra N.B., Majdan M., Majeed A., Malekzadeh R., Manda A.-L., Mansournia M.A., Massenburg B.B., Mate K.K.V., Mehndiratta M.M., Mehta V., Meles H., Melese A., Memiah P.T.N., Mendoza W., Mengistu G., Meretoja A., Meretoja T.J., Mestrovic T., Miazgowski T., Miller T.R., Mini G.K., Mirica A., Mirrakhimov E.M., Moazen B., Mohammadi M., Molokhia M., Monasta L., Mondello S., Moosazadeh M., Moradi G., Moradi M., Moradi-Lakeh M., Moradinazar M., Morrison S.D., Moschos M.M., Mousavi S.M., Murthy S., Musa K.I., Mustafa G., Naghavi M., Naik G., Najafi F., Nangia V., Nascimento B.R., Negoi I., Nguyen T.H., Nichols E., Ningrum D.N.A., Nirayo Y.L., Nyasulu P.S., Ogbo F.A., Oh I.-H., Okoro A., Olagunju A.T., Olagunju T.O., Olivares P.R., Otstavnov S.S., Owolabi M.O., P A M., Pakhale S., Pandey A.R., Pesudovs K., Pinilla-Monsalve G.D., Polinder S., Poustchi H., Prakash S., Qorbani M., Radfar A., Rafay A., Rafiei A., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Rahman M.A., Rai R.K., Rajati F., Ram U., Rawaf D.L., Rawaf S., Reiner R.C., Reis C., Renzaho A.M.N., Resnikoff S., Rezaei S., Rezaeian S., Roever L., Ronfani L., Roshandel G., Roy N., Ruhago G.M., Saddik B., Safari H., Safiri S., Sahraian M.A., Salamati P., Saldanha R.D.F., Samy A.M., Sanabria J., Santos J.V., Santric Milicevic M.M.M., Sartorius B., Satpathy M., Savuon K., Schneider I.J.C., Schwebel D.C., Sepanlou S.G., Shabaninejad H., Shaikh M.A.A., Shams-Beyranvand M., Sharif M., Sharif-Alhoseini M., Shariful Islam S.M., She J., Sheikh A., Shen J., Sheth K.N., Shibuya K., Shiferaw M.S., Shigematsu M., Shiri R., Shiue I., Shoman H., Siabani S., Siddiqi T.J., Silva J.P., Silveira D.G.A., Sinha D.N., Smith M., Soares Filho A.M., Sobhani S., Soofi M., Soriano J.B., Soyiri I.N., Stein D.J., Stokes M.A., Sufiyan M.B., Sunguya B.F., Sunshine J.E., Sykes B.L., Szoeke C.E.I., Tabares-Seisdedos R., Te Ao B.J., Tehrani-Banihashemi A., Tekle M.G., Temsah M.-H., Temsah O., Topor-Madry R., Tortajada-Girbes M., Tran B.X., Tran K.B., Tudor Car L., Ukwaja K.N., Ullah I., Usman M.S., Uthman O.A., Valdez P.R., Vasankari T.J., Venketasubramanian N., Violante F.S., Wagnew F.W.S., Waheed Y., Wang Y.-P., Weldegwergs K.G., Werdecker A., Wijeratne T., Winkler A.S., Wyper G.M.A., Yano Y., Yaseri M., Yasin Y.J., Ye P., Yimer E.M., Yip P., Yisma E., Yonemoto N., Yoon S.-J., Yost M.G., Younis M.Z., Yousefifard M., Yu C., Zaidi Z., Zaman S.B., Zamani M., Zenebe Z.M., Zodpey S., Feigin V.L., Vos T., Murray C.J.L., and Bill & Melinda Gates Foundation

Subjects
Science & Technology, Neurology & Neurosurgery, NEW-ZEALAND, Clinical Neurology, UNITED-STATES, 1103 Clinical Sciences, Epidemology, spinal cord injury, Global Burden of Disease, Traumatic brain injury, United-States, New-Zealand, Epidemology, Survival, GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators, Brain Injuries, Traumatic, SURVIVAL, brain injury, spinal cord injury, EPIDEMIOLOGY, Global Burden Disease, Neurosciences & Neurology, 1109 Neurosciences, Life Sciences & Biomedicine, Spinal Cord Injuries
Abstract

BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 to measure the global, regional, and national burden of TBI and SCI by age and sex. We measured the incidence and prevalence of all causes of injury requiring medical care in inpatient and outpatient records, literature studies, and survey data. By use of clinical record data, we estimated the proportion of each cause of injury that required medical care that would result in TBI or SCI being considered as the nature of injury. We used literature studies to establish standardised mortality ratios and applied differential equations to convert incidence to prevalence of long-term disability. Finally, we applied GBD disability weights to calculate YLDs. We used a Bayesian meta-regression tool for epidemiological modelling, used cause-specific mortality rates for non-fatal estimation, and adjusted our results for disability experienced with comorbid conditions. We also analysed results on the basis of the Socio-demographic Index, a compound measure of income per capita, education, and fertility. FINDINGS: In 2016, there were 27·08 million (95% uncertainty interval [UI] 24·30-30·30 million) new cases of TBI and 0·93 million (0·78-1·16 million) new cases of SCI, with age-standardised incidence rates of 369 (331-412) per 100 000 population for TBI and 13 (11-16) per 100 000 for SCI. In 2016, the number of prevalent cases of TBI was 55·50 million (53·40-57·62 million) and of SCI was 27·04 million (24·98-30·15 million). From 1990 to 2016, the age-standardised prevalence of TBI increased by 8·4% (95% UI 7·7 to 9·2), whereas that of SCI did not change significantly (-0·2% [-2·1 to 2·7]). Age-standardised incidence rates increased by 3·6% (1·8 to 5·5) for TBI, but did not change significantly for SCI (-3·6% [-7·4 to 4·0]). TBI caused 8·1 million (95% UI 6·0-10·4 million) YLDs and SCI caused 9·5 million (6·7-12·4 million) YLDs in 2016, corresponding to age-standardised rates of 111 (82-141) per 100 000 for TBI and 130 (90-170) per 100 000 for SCI. Falls and road injuries were the leading causes of new cases of TBI and SCI in most regions. INTERPRETATION: TBI and SCI constitute a considerable portion of the global injury burden and are caused primarily by falls and road injuries. The increase in incidence of TBI over time might continue in view of increases in population density, population ageing, and increasing use of motor vehicles, motorcycles, and bicycles. The number of individuals living with SCI is expected to increase in view of population growth, which is concerning because of the specialised care that people with SCI can require. Our study was limited by data sparsity in some regions, and it will be important to invest greater resources in collection of data for TBI and SCI to improve the accuracy of future assessments. FUNDING: Bill & Melinda Gates Foundation. Bill & Melinda Gates Foundation We acknowledge the funding and support of the Bill & Melinda Gates Foundation. AK was supported by the Miguel Servet contract, which was financed by the CP13/00150 and PI15/00862 projects integrated into the National Research, Development, and Implementation,and funded by the Instituto de Salud Carlos III General Branch Evaluation and Promotion of Health Research and the European Regional Development Fund (ERDF-FEDER). AMS is supported by the Egyptian Fulbright Mission Program. AF acknowledges the Federal University of Sergipe (Sergipe, Brazil). AA received financial assistance from the Indian Department of Science and Technology (New Delhi, India) through the INSPIRE faculty programme. AS is supported by Health Data Research UK. DJS is supported by the South African Medical Research Council. AB is supported by the Public Health Agency of Canada. SMSI received a senior research fellowship from the Institute for Physical Activity and Nutrition, Deakin University (Waurn Ponds, VIC, Australia), and a career transition grant from the High Blood Pressure Research Council of Australia. FP and CF acknowledge support from the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundação para a Ciência e a Tecnologia, and Ministério da Educação e Ciência) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020 UID/QUI/50006/2013. TB acknowledges financial support from the Institute of Medical Research and Medicinal Plant Studies, Yaoundé, Cameroon. AM of Imperial College London is grateful for support from the Northwest London National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research andCare and the Imperial NIHR Biomedical Research Centre. KD is funded by a Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine (grant number 201900). PSA is supported by an Australian National Health and Medical Research Council Early Career Fellowship. RT-S was supported in part by grant number PROMETEOII/2015/021 from Generalitat Valenciana and the national grant PI17/00719 from ISCIII-FEDER. The Serbian part of this contribution (by MJ) has been co-financed with grant OI175014 from the Serbian Ministry of Education, Science and Technological Development; publication of results was not contingent upon the Ministry’s approval. MMMSM acknowledges support from the Serbian Ministry of Education, Science and Technological Development (contract 175087). MM’s research was supported by the NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust (London, UK) and King’s College London. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the UK Department of Health. TWB was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt professor award, which was funded by the German Federal Ministry of Education and Research Sí

Published
2019

26. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author

Dicker, Daniel, Nguyen, Grant, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M, Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abdel-Rahman, Omar, Abdi, Alireza, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abdurahman, Ahmed Abdulahi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abebo, Teshome Abuka, Aboyans, Victor, Abraha, Haftom Niguse, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen ME, Accrombessi, Manfred Mario Kokou, Acharya, Pawan, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Adhikari, Tara Ballav, Adib, Mina G, Adou, Ars&#232, ne Kouablan, Adsuar, Jose C, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Aggarwal, Rakesh, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Agrawal, Anurag, Ahmadi, Mehdi, Ahmadi, Alireza, Ahmadieh, Hamid, Ahmed, Mohamed Lemine Cheikh brahim, Ahmed, Sayem, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akanda, Ali S, Akbari, Mohammad Esmaeil, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akseer, Nadia, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alebel, Animut, Aleman, Alicia V, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Raghib, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala&apos, a, Alla, Fran&#231, ois, Allebeck, Peter, Allen, Christine A, Alonso, Jordi, Al-Raddadi, Rajaa M, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Anlay, Degefaye Zelalem, Ansari, Hossein, Ansariadi, Ansariadi, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Appiah, Seth Christopher Yaw, Aremu, Olatunde, Areri, Habtamu Abera, 196, rnl&#246, v, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna K, Asadi-Lari, Mohsen, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Asgedom, Solomon Weldegebreal, Assadi, Reza, Ataro, Zerihun, Atey, Tesfay Mehari Mehari, Athari, Seyyed Shamsadin, Atique, Suleman, Atre, Sachin R, Atteraya, Madhu Sudhan, Attia, Engi F, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide F G A, Awasthi, Ashish, Awuah, Baffour, Ayala Quintanilla, Beatriz Paulina, Ayele, Henok Tadesse, Ayele, Yohanes, Ayer, Rakesh, Ayuk, Tambe B, Azzopardi, Peter S, Azzopardi-Muscat, Natasha, Badali, Hamid, Badawi, Alaa, Balakrishnan, Kalpana, Bali, Ayele Geleto, Banach, Maciej, Banstola, Amrit, Barac, Aleksandra, Barboza, Miguel A, Barquera, Simon, Barrero, Lope H, Basaleem, Huda, Bassat, Quique, Basu, Arindam, Basu, Sanjay, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, B&#233, jot, Yannick, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Belay, Aregawi Gebreyesus, Belay, Ezra, Belay, Saba Abraham, Belay, Yihalem Abebe, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Berhane, Adugnaw, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bertolacci, Gregory J, Beuran, Mircea, Beyranvand, Tina, Bhala, Neeraj, Bhatia, Eesh, Bhatt, Samir, Bhattarai, Suraj, Bhaumik, Soumyadeeep, Bhutta, Zulfiqar A, Biadgo, Belete, Bijani, Ali, Bikbov, Boris, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Birlik, Sait Mentes, Birungi, Charles, Bisanzio, Donal, Biswas, Tuhin, Bj&#248, rge, Tone, Bleyer, Archie, Basara, Berrak Bora, Bose, Dipan, Bosetti, Cristina, Boufous, Soufiane, Bourne, Rupert, Brady, Oliver J, Bragazzi, Nicola Luigi, Brant, Luisa C, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Britton, Gabrielle, Brugha, Traolach, Burke, Kristin E, Busse, Reinhard, Butt, Zahid A, Cahuana-Hurtado, Lucero, Callender, Charlton S K H, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cano, Jorge, Car, Mate, C&#225, rdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carter, Austin, Carvalho, F&#233, lix, Casta&#241, eda-Orjuela, Carlos A, Castillo Rivas, Jacqueline, Castro, Franz, Catal&#225, L&#243, pez, Ferr&#225, n, 199, avlin, Alanur, Cerin, Ester, Chaiah, Yazan, Champs, Ana Paula, Chang, Hsing-Yi, Chang, Jung-Chen, Chattopadhyay, Aparajita, Chaturvedi, Pankaj, Chen, Wanqing, Chiang, Peggy Pei-Chia, Chimed-Ochir, Odgerel, Chin, Ken Lee, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal, Choi, Jee-Young J, Christensen, Hanne, Christopher, Devasahayam J, Chung, Sheng-Chia, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Claro, Rafael M, Cohen, Aaron J, Collado-Mateo, Daniel, Constantin, Maria-Magdalena, Conti, Sara, Cooper, Cyrus, Cooper, Leslie Trumbull, Cortesi, Paolo Angelo, Cortinovis, Monica, Cousin, Ewerton, Criqui, Michael H, Cromwell, Elizabeth A, Crowe, Christopher Stephen, Crump, John A, Cucu, Alexandra, Cunningham, Matthew, Daba, Alemneh Kabeta, Dachew, Berihun Assefa, Dadi, Abel Fekadu, Dandona, Lalit, Dandona, Rakhi, Dang, Anh Kim, Dargan, Paul I, Daryani, Ahmad, Das, Siddharth K, Das Gupta, Rajat, das Neves, Jos&#233, Dasa, Tamirat Tesfaye, Dash, Aditya Prasad, Weaver, Nicole Davis, Davitoiu, Dragos Virgil, Davletov, Kairat, Dayama, Anand, Courten, Barbora de, De la Hoz, Fernando Pio, De leo, Diego, De Neve, Jan-Walter, Degefa, Meaza Girma, Degenhardt, Louisa, Degfie, Tizta T, Deiparine, Selina, Dellavalle, Robert P, Demoz, Gebre Teklemariam, Demtsu, Balem Betsu, Denova-Guti&#233, rrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Des Jarlais, Don C, Dessie, Getenet Ayalew, Dey, Subhojit, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Ding, Eric L, Djalalinia, Shirin, Doku, David Teye, Dolan, Kate A, Donnelly, Christl A, Dorsey, E Ray, Douwes-Schultz, Dirk, Doyle, Kerrie E, Drake, Thomas M, Driscoll, Tim Robert, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Duncan, Bruce B, Duraes, Andre R, Ebrahimi, Hedyeh, Ebrahimpour, Soheil, Edessa, Dumessa, Edvardsson, David, Eggen, Anne Elise, El Bcheraoui, Charbel, El Sayed Zaki, Maysaa, Elfaramawi, Mohammed, El-Khatib, Ziad, Ellingsen, Christian Lycke, Elyazar, Iqbal R F, Enayati, Ahmadali, Endries, Aman Yesuf Yesuf, Benjamin, Er, Ermakov, Sergey Petrovich, Eshrati, Babak, Eskandarieh, Sharareh, Esmaeili, Reza, Esteghamati, Alireza, Esteghamati, Sadaf, Fakhar, Mahdi, Fakhim, Hamed, Farag, Tamer, Faramarzi, Mahbobeh, Fareed, Mohammad, Farhadi, Farzaneh, Farid, Talha A, Farinha, Carla Sofia e S&#225, Farioli, Andrea, Faro, Andre, Farvid, Maryam S, Farzadfar, Farshad, Farzaei, Mohammad Hosein, Fazeli, Mir Sohail, Feigin, Valery L, Feigl, Andrea B, Feizy, Fariba, Fentahun, Netsanet, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, Joao C, Feyissa, Garumma Tolu, Fijabi, Daniel Obadare, Filip, Irina, Finegold, Samuel, Fischer, Florian, Flor, Luisa Sorio, Foigt, Nataliya A, Ford, John A, Foreman, Kyle J, Fornari, Carla, Frank, Tahvi D, Franklin, Richard Charles, Fukumoto, Takeshi, Fuller, John E, Fullman, Nancy, F&#252, rst, Thomas, Furtado, Jo&#227, o M, Futran, Neal D, Galan, Adriana, Gallus, Silvano, Gambashidze, Ketevan, Gamkrelidze, Amiran, Gankpe, Fortune Gbetoho, Garcia-Basteiro, Alberto L, Garcia-Gordillo, Miguel A, Gebre, Teshome, Gebre, Abadi Kahsu, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Gelano, Tilayie Feto, Gelaw, Yalemzewod Assefa, Geleijnse, Johanna M, Genova-Maleras, Ricard, Gessner, Bradford D, Getachew, Sefonias, Gething, Peter W, Gezae, Kebede Embaye, Ghadami, Mohammad Rasoul, Ghadimi, Reza, Ghasemi Falavarjani, Khalil, Ghasemi-Kasman, Maryam, Ghiasvand, Hesam, Ghimire, Mamata, Ghoshal, Aloke Gopal, Gill, Paramjit Singh, Gill, Tiffany K, Gillum, Richard F, Giussani, Giorgia, Goenka, Shifalika, Goli, Srinivas, Gomez, Ricardo Santiago, Gomez-Cabrera, Mari Carmen, G&#243, mez-Dant&#233, s, Hector, Gona, Philimon N, Goodridge, Amador, Gopalani, Sameer Vali, Goto, Atsushi, Goulart, Alessandra C, Goulart, B&#225, rbara Niegia Garcia, Grada, Ayman, Grosso, Giuseppe, Gugnani, Harish Chander, Guimaraes, Andre Luiz Sena, Guo, Yuming, Gupta, Prakash C, Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gyawali, Bishal, Haagsma, Juanita A, Hachinski, Vladimir, Hafezi-Nejad, Nima, Hagos, Tekleberhan B, Hailegiyorgis, Tewodros Tesfa, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arya, Haj-Mirzaian, Arvin, Hamadeh, Randah R, Hamidi, Samer, Handal, Alexis J, Hankey, Graeme J, Harb, Hilda L, Harikrishnan, Sivadasanpillai, Haririan, Hamidreza, Haro, Josep Maria, Hasan, Mehedi, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Roderick J, Hay, Simon I, Yihua, He, Hedayatizadeh-Omran, Akbar, Hegazy, Mohamed I, Heibati, Behzad, Heidari, Mohsen, Hendrie, Delia, Henok, Andualem, Henry, Nathaniel J, Heredia-Pi, Ileana, Herteliu, Claudiu, Heydarpour, Fatemeh, Heydarpour, Pouria, Heydarpour, Sousan, Hibstu, Desalegn Tsegaw, Hoek, Hans W, Hole, Michael K, Homaie Rad, Enayatollah, Hoogar, Praveen, Horino, Masako, Hosgood, H Dean, Hosseini, Seyed Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Sorin, Hostiuc, Mihaela, Hotez, Peter J, Hoy, Damian G, Hsairi, Mohamed, Htet, Aung Soe, Guoqing, Hu, Huang, John J, Husseini, Abdullatif, Hussen, Mohammedaman Mama, Hutfless, Susan, Iburg, Kim Moesgaard, Igumbor, Ehimario U, Ikeda, Chad Thomas, Ilesanmi, Olayinka Stephen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Isehunwa, Oluwaseyi Oluwakemi, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Jahangiry, Leila, Jahanmehr, Nader, Jain, Rajesh, Jain, Sudhir Kumar, Jakovljevic, Mihajlo, James, Spencer L, Javanbakht, Mehdi, Jayaraman, Sudha, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Ravi Prakash, Jha, Vivekanand, John S, Ji, Johnson, Sarah Charlotte, Jonas, Jost B, Joshi, Ankur, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, J&#252, risson, Mikk, Madhanraj, K, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kahssay, Molla, Kalani, Rizwan, Kapil, Umesh, Karami, Manoochehr, Karami Matin, Behzad, Karch, Andr&#233, Karema, Corine, Karimi, Narges, Karimi, Seyed M, Karimi-Sari, Hamidreza, Kasaeian, Amir, Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassa, Zemenu Yohannes, Kassebaum, Nicholas J, Katibeh, Marzieh, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Kazemeini, Hossein, Kazemi, Zhila, Karyani, Ali Kazemi, K C, Prakash, Kebede, Seifu, Keiyoro, Peter Njenga, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalid, Nauman, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Muhammad Shahzeb, Khan, Muhammad Ali, Khang, Young-Ho, Khanna, Tripti, Khater, Mona M, Khatony, Alireza, Khazaie, Habibolah, Khoja, Abdullah T, Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kiadaliri, Aliasghar A, Kibret, Getiye D Dejenu, Kim, Cho-il, Kim, Daniel, Kim, Jun Y, Kim, Young-Eun, Kimokoti, Ruth W, Kinfu, Yohannes, Kinra, Sanjay, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kissoon, Niranjan, Kivim&#228, ki, Mika, Kleber, Marcus E, Knibbs, Luke D, Knudsen, Ann Kristin Skrindo, Kochhar, Sonali, Kokubo, Yoshihiro, Kolola, Tufa, Kopec, Jacek A, Kosek, Margaret N, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krishnaswami, Sanjay, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kudom, Andreas A, Kuipers, Ernst J, Kulikoff, Xie Rachel, Kumar, G Anil, Kumar, Manasi, Kumar, Pushpendra, Kumsa, Fekede Asefa, Kutz, Michael J, Lad, Sheetal D, Lafranconi, Alessandra, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lam, Hilton, Lami, Faris Hasan, Lan, Qing, Langan, Sin&#233, ad M, Lansingh, Van C, Lansky, Sonia, Larson, Heidi Jane, Laryea, Dennis Odai, Lassi, Zohra S, Latifi, Arman, Lavados, Pablo M, Laxmaiah, Avula, Lazarus, Jeffrey V, Lebedev, Georgy, Lee, Paul H, Leigh, James, Leshargie, Cheru Tesema, Leta, Samson, Levi, Miriam, Shanshan, Li, Yichong, Li, Xiaohong, Li, Liang, Juan, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Lee-Ling, Lim, Stephen S, Limenih, Miteku Andualem, Linn, Shai, Liu, Shiwei, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lonsdale, Chris, Lorch, Scott A, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Tim C D, Lunevicius, Raimundas, Lyons, Ronan A, Stefan, Ma, Mabika, Crispin, Macarayan, Erlyn Rachelle King, Mackay, Mark T, Maddison, Emilie R, Maddison, Ralph, Madotto, Fabiana, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Maghavani, Dhaval P, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malik, Manzoor Ahmad, Malta, Deborah Carvalho, Mamun, Abdullah A, Manamo, Wondimu Ayele, Manda, Ana-Laura, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Mapoma, Chabila Christopher, Marami, Dadi, Maravilla, Joemer C, Marcenes, Wagner, Marina, Shakhnazarova, Martinez-Raga, Jose, Martins, Sheila C O, Martins-Melo, Francisco Rogerl&#226, ndio, M&#228, rz, Winfried, Marzan, Melvin B, Mashamba-Thompson, Tivani Phosa, Masiye, Felix, Massenburg, Benjamin Ballard, Maulik, Pallab K, Mazidi, Mohsen, McGrath, John J, McKee, Martin, Mehata, Suresh, Mehendale, Sanjay Madhav, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehta, Kala M, Mehta, Varshil, Mekonen, Tesfa, Mekonnen, Tefera Chane, Meles, Hagazi Gebre, Meles, Kidanu Gebremariam, Melese, Addisu, Melku, Mulugeta, Memiah, Peter T N, Memish, Ziad A, Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Mensah, George A, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Mezgebe, Haftay Berhane, Miangotar, Yode, Miazgowski, Bartosz, Miazgowski, Tomasz, Miller, Ted R, Mini, G K, Mirica, Andreea, Mirrakhimov, Erkin M, Misganaw, Awoke Temesgen, Moazen, Babak, Moges, Nurilign Abebe, Mohammad, Karzan Abdulmuhsin, Mohammadi, Moslem, Mohammadifard, Noushin, Mohammadi-Khanaposhtani, Maryam, Mohammadnia-Afrouzi, Mousa, Mohammed, Shafiu, Mohammed, Mohammed A, Mohan, Viswanathan, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moradi, Ghobad, Moradi, Mahmoudreza, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Morawska, Lidia, Moreno Vel&#225, squez, Ilais, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Moschos, Marilita M, Mousavi, Seyyed Meysam, Muche, Achenef Asmamaw, Muchie, Kindie Fentahun, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Mullany, Erin C, Muller, Kate, Murhekar, Manoj, Murphy, Tasha B, Murthy, G V S, Murthy, Srinivas, Musa, Jonah, Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nachega, Jean B, Nagel, Gabriele, Naghavi, Mohsen, Naheed, Aliya, Nahvijou, Azin, Naik, Gurudatta, Nair, Sanjeev, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Nascimento, Bruno Ramos, Nawaz, Haseeb, Ncama, Busisiwe P, Neamati, Nahid, Negoi, Ionut, Negoi, Ruxandra Irina, Neupane, Subas, Newton, Charles Richard James, Ngalesoni, Frida N, Ngunjiri, Josephine W, Nguyen, Ha Thu, Nguyen, Huong Thanh, Nguyen, Long Hoang, Nguyen, Michele, Nguyen, Trang Huyen, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nisar, Muhammad Imran, Nixon, Molly R, Nolutshungu, Nomonde, Nomura, Shuhei, Norheim, Ole F, Noroozi, Mehdi, Norrving, Bo, Noubiap, Jean Jacques, Nouri, Hamid Reza, Nourollahpour Shiadeh, Malihe, Nowroozi, Mohammad Reza, Nsoesie, Elaine O, Nyasulu, Peter S, Ofori-Asenso, Richard, Ogah, Okechukwu Samuel, Ogbo, Felix Akpojene, In-Hwan, Oh, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew T, Olagunju, Tinuke O, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Sok King, Opio, John Nelson, Oren, Eyal, Ortiz, Justin R, Ortiz, Alberto, Ota, Erika, Otstavnov, Stanislav S, 216, verland, Simon, Owolabi, Mayowa Ojo, Oyekale, Abayomi Samuel, P A, Mahesh, Pacella, Rosana, Pakhale, Smita, Pakhare, Abhijit P, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Pandey, Achyut Raj, Pandian, Jeyaraj Durai, Parisi, Andrea, Park, Eun-Kee, Parry, Charles D H, Parsian, Hadi, Patel, Shanti, Patle, Ajay, Patten, Scott B, Patton, George C, Paudel, Deepak, Pearce, Neil, Peprah, Emmanuel K, Pereira, Alexandre, Pereira, David M, Perez, Krystle M, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Petri, William A, Petzold, Max, Phillips, Michael R, Pigott, David M, Pillay, Julian David, Pirsaheb, Meghdad, Pishgar, Farhad, Plass, Dietrich, Polinder, Suzanne, Pond, Constance Dimity, Popova, Svetlana, Postma, Maarten J, Pourmalek, Farshad, Pourshams, Akram, Poustchi, Hossein, Prabhakaran, Dorairaj, Prakash, V, Prakash, Swayam, Prasad, Narayan, Qorbani, Mostafa, Quistberg, D Alex, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi, Kazem, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rahman, Sajjad ur, Rai, Rajesh Kumar, Rajati, Fatemeh, Rajsic, Sasa, Raju, Sree Bhushan, Ram, Usha, Ranabhat, Chhabi Lal, Ranjan, Prabhat, Ranta, Anna, Rasella, Davide, Rawaf, David Laith, Rawaf, Salman, Ray, Sarah E, Razo-Garc&#237, a, Christian, Rego, Maria Albertina Santiago, Rehm, J&#252, rgen, Reiner, Robert C, Reinig, Nickolas, Reis, Cesar, Remuzzi, Giuseppe, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Satar, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Riahi, Seyed Mohammad, Ribeiro, Antonio Luiz P, Riojas, Horacio, Rios-Blancas, Maria Jesus, Roba, Kedir Teji, Robinson, Stephen R, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Roshchin, Denis O, Rostami, Ali, Rothenbacher, Dietrich, Rubagotti, Enrico, Ruhago, George Mugambage, Saadat, Soheil, Sabde, Yogesh Damodar, Sachdev, Perminder S, Saddik, Basema, Sadeghi, Ehsan, Moghaddam, Sahar Saeedi, Safari, Hosein, Safari, Yahya, Safari-Faramani, Roya, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, Haniye Sadat, Salahshoor, Mohamadreza, Salam, Nasir, Salama, Joseph S, Salamati, Payman, Saldanha, Raphael de Freitas, Salimi, Yahya, Salimzadeh, Hamideh, Salz, Inbal, Sambala, Evanson Zondani, Samy, Abdallah M, Sanabria, Juan, Sanchez-Ni&#241, o, Maria Dolores, Santos, Itamar S, Santos, Jo&#227, o Vasco, Santric Milicevic, Milena M, Sao Jose, Bruno Piassi, Sardana, Mayank, Sarker, Abdur Razzaque, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Savic, Miloje, Sawant, Arundhati R, Sawhney, Monika, Saxena, Sonia, Sayyah, Mehdi, Scaria, Vinod, Schaeffner, Elke, Schelonka, Kathryn, Schmidt, Maria In&#234, s, Schneider, Ione J C, Sch&#246, ttker, Ben, Schutte, Aletta Elisabeth, Schwebel, David C, Schwendicke, Falk, Scott, James G, Sekerija, Mario, Sepanlou, Sadaf G, Serv&#225, n-Mori, Edson, Shabaninejad, Hosein, Shackelford, Katya Anne, Shafieesabet, Azadeh, Shaheen, Amira A, Shaikh, Masood Ali, Shakir, Raad A, Shams-Beyranvand, Mehran, Shamsi, MohammadBagher, Shamsizadeh, Morteza, Sharafi, Heidar, Sharafi, Kiomars, Sharif, Mehdi, Sharif-Alhoseini, Mahdi, Sharma, Meenakshi, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikh, Aziz, Sheth, Kevin N, Shi, Peilin, Shibuya, Kenji, Shifa, Girma Temam, Shiferaw, Mekonnen Sisay, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Shokraneh, Farhad, Shrime, Mark G, Shukla, Sharvari Rahul, Si, Si, Siabani, Soraya, Siddiqi, Tariq J, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silpakit, Naris, Silva, Diego Augusto Santos, Silva, Jo&#227, o Pedro, Silveira, Dayane Gabriele Alves, Singam, Narayana Sarma Venkata, Singh, Jasvinder A, Singh, Virendra, Sinha, Anju Pradhan, Sinha, Dhirendra Narain, Sitas, Freddy, Skirbekk, Vegard, Sliwa, Karen, Soares Filho, Adauto Martins, Sobaih, Badr Hasan, Sobhani, Soheila, Soofi, Moslem, Soriano, Joan B, Soyiri, Ireneous N, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Srivastava, Rakesh Kumar, Starodubov, Vladimir I, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J, Steiner, Caitlyn, Stewart, Leo G, Stokes, Mark A, Sudaryanto, Agus, Sufiyan, Mu&apos, awiyyah Babale, Sulo, Gerhard, Sunguya, Bruno F, Sur, Patrick John, Sutradhar, Ipsita, Sykes, Bryan L, Sylaja, P N, Sylte, Dillon O, Szoeke, Cassandra E I, Tabar&#233, s-Seisdedos, Rafael, Tabuchi, Takahiro, Tadakamadla, Santosh Kumar, Takahashi, Ken, Tandon, Nikhil, Tassew, Aberash Abay, Tassew, Segen Gebremeskel, Tavakkoli, Mohammad, Taveira, Nuno, Tawye, Nega Yimer, Tehrani-Banihashemi, Arash, Tekalign, Tigist Gashaw, Tekle, Merhawi Gebremedhin, Temesgen, Habtamu, Temsah, Mohamad-Hani, Temsah, Omar, Terkawi, Abdullah Sulieman, Teshale, Manaye Yihune, Tessema, Belay, Teweldemedhin, Mebrahtu, Thakur, Jarnail Singh, Thankappan, Kavumpurathu Raman, Thirunavukkarasu, Sathish, Thomas, Laura Anne, Thomas, Nihal, Thrift, Amanda G, Tilahun, Binyam, Quyen G, To, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Torre, Anna E, Tortajada-Girb&#233, s, Miguel, Tovani-Palone, Marcos Roberto, Towbin, Jeffrey A, Tran, Bach Xuan, Tran, Khanh Bao, Tripathi, Suryakant, Tripathy, Srikanth Prasad, Truelsen, Thomas Clement, Truong, Nu Thi, Tsadik, Afewerki Gebremeskel, Tsilimparis, Nikolaos, Tudor Car, Lorainne, Tuzcu, E Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Ullah, Irfan, Usman, Muhammad Shariq, Uthman, Olalekan A, Uzun, Selen Beg&#252, m, Vaduganathan, Muthiah, Vaezi, Afsane, Vaidya, Gaurang, Valdez, Pascual R, Varavikova, Elena, Varughese, Santosh, Vasankari, Tommi Juhani, Vasconcelos, Ana Maria Nogales, Venketasubramanian, Narayanaswamy, Vidavalur, Ramesh, Villafaina, Santos, Violante, Francesco S, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vosoughi, Kia, Vujcic, Isidora S, Wagner, Gregory R, Wagnew, Fasil Wagnew Shiferaw, Waheed, Yasir, Wang, Yanping, Wang, Yuan-Pang, Wassie, Molla Mesele, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Weiss, Jordan, Weldegebreal, Fitsum, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Widecka, Justyna, Widecka, Katarzyna, Wijeratne, Tissa, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D A, Wondemagegn, Sintayehu Ambachew, Shouling, Wu, Wyper, Grant M A, Gelin, Xu, Yadav, Rajaram, Yakob, Bereket, Yamada, Tomohide, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Yasin, Yasin Jemal, Pengpeng, Ye, Yearwood, Jamal A, Yent&#252, r, G&#246, kalp Kadri, Yeshaneh, Alex, Yimer, Ebrahim M, Yip, Paul, Yisma, Engida, Yonemoto, Naohiro, Yoon, Seok-Jun, York, Hunter W, Yotebieng, Marcel, Younis, Mustafa Z, Yousefifard, Mahmoud, Chuanhua, Yu, Zachariah, Geevar, Zadnik, Vesna, Zafar, Shamsa, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zare, Zohreh, Zeeb, Hajo, Zeleke, Mulugeta Molla, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Kai, Zhang, Xueying, Zhou, Maigeng, Zhu, Jun, Zodpey, Sanjay, Zucker, Inbar, Zuhlke, Liesl Joanna J, Lopez, Alan D, Gakidou, Emmanuela, and Murray, Christopher J L

Subjects
mortality, life expectancy, global burden of disease
Published
2018

27. How do Japanese rate the severity of different diseases and injuries?—an assessment of disability weights for 231 health states by 37,318 Japanese respondents.

Author

Nomura, Shuhei, Yamamoto, Yoshiko, Yoneoka, Daisuke, Haagsma, Juanita A., Salomon, Joshua A., Ueda, Peter, Mori, Rintaro, Santomauro, Damian, Vos, Theo, and Shibuya, Kenji

Subjects
SPINAL cord injuries, SUBSTANCE abuse, SAMPLE size (Statistics), STATISTICAL reliability, LIFE expectancy, GLOBAL burden of disease, DISABILITY evaluation, REGRESSION analysis, UNCERTAINTY, SEVERITY of illness index, ATTITUDES toward illness, COMPARATIVE studies, SURVEYS, QUESTIONNAIRES, ANEMIA, HEARING disorders, RESEARCH funding, DESCRIPTIVE statistics, PEOPLE with disabilities, AMPUTATION, VISION disorders, DATA analysis software, STATISTICAL sampling, POPULATION health, PUBLIC opinion, ATTITUDES toward disabilities, BONE fractures
Abstract

Background: Disability weights (DWs) are weight factors that reflect the severity of health states for estimates of disability-adjusted life years. A new set of global DWs was published for the Global Burden of Diseases and Injuries (GBD) 2013 study, which relied on sampling from various world regions, but included little data for countries in East Asia. This study aimed to measure DWs in Japan using comparable methods, and compare the results with previous estimates from the GBD 2013 DW study. Methods: We conducted a web-based survey in 2019 to estimate DWs for 231 health states for the Japanese population. The survey included five new health states but otherwise followed the method of the GBD DW measurement study. The survey consisted of 15 paired comparison (PC) questions and 3 population health equivalence questions (PHE) per respondent. We analyzed PC data using probit regression and rescaled results to DW units between 0 (equivalent to full health) and 1 (equivalent to death). Findings: We considered 37,318 nationally representative respondents. The values of the resulting DWs ranged from 0.707 (95% uncertainty interval (UI) 0.527–0.842) for spinal cord injury at neck level (untreated) to 0.004 (UI 0.001–0.009) for mild anemia. High correlation between Japanese DW and GBD 2013 DW was observed, but there was considerable disagreement. Out of 226 comparable health states, 55 (24.3%) showed more than a factor-of-two difference, of which 41 (74.6%) had a higher value in Japanese DW. Many of the health states with higher DW in the Japan study were injuries, including amputation and fracture, and hearing and vision loss, while mental, behavioral, and substance use disorders generally tended to be lower. Conclusions: This study has created an empirical basis for assessment of Japanese DWs of health status. The findings from this study based on the Japanese population suggest that there might be contextual differences in rating the severity of health states compared to previous surveys conducted elsewhere. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Revised estimates of leprosy disability weights for assessing the global burden of disease: A systematic review and individual patient data meta-analysis.

Author

Nanjan Chandran, Shri Lak, Tiwari, Anuj, Lustosa, Anselmo Alves, Demir, Betul, Bowers, Bob, Albuquerque, Rachel Gimenes Rodrigues, Prado, Renata Bilion Ruiz, Lambert, Saba, Watanabe, Hiroyuki, Haagsma, Juanita, and Richardus, Jan Hendrik

Subjects
GLOBAL burden of disease, HANSEN'S disease, MYCOBACTERIUM leprae, DISABILITIES, BACTERIAL diseases
Abstract

Background: Leprosy is a chronic bacterial infection caused by Mycobacterium leprae, which may lead to physical disability, stigma, and discrimination. The chronicity of the disease and disabilities are the prime contributors to the disease burden of leprosy. The current figures of the disease burden in the 2017 global burden of disease study, however, are considered to be under-estimated. In this study, we aimed to systematically review the literature and perform individual patient data meta-analysis to estimate new disability weights for leprosy, using Health-Related Quality of Life (HRQOL) data. Methodology/principal findings: The search strategy included all major databases with no restriction on language, setting, study design, or year of publication. Studies on human populations that have been affected by leprosy and recorded the HRQOL with the Short form tool, were included. A consortium was formed with authors who could share the anonymous individual-level data of their study. Mean disability weight estimates, sorted by the grade of leprosy disability as defined by WHO, were estimated for individual participant data and pooled using multivariate random-effects meta-analysis. Eight out of 14 studies from the review were included in the meta-analysis due to the availability of individual-level data (667 individuals). The overall estimated disability weight for grade 2 disability was 0.26 (95%CI: 0.18–0.34). For grade 1 disability the estimated weight was 0.19 (95%CI: 0.13–0.26) and for grade 0 disability it was 0.13 (95%CI: 0.06–0.19). The revised disability weight for grade 2 leprosy disability is four times higher than the published GBD 2017 weights for leprosy and the grade 1 disability weight is nearly twenty times higher. Conclusions/significance: The global burden of leprosy is grossly underestimated. Revision of the current disability weights and inclusion of disability caused in individuals with grade 0 leprosy disability will contribute towards a more precise estimation of the global burden of leprosy. Author summary: Leprosy is a chronic, disabling disease that causes various kinds of disability in the affected person. This includes physical impairment, activity limitation, and participation restriction. However, the published global burden of disease estimates for leprosy is considered to be a gross under-estimation. Disability weights form an integral component in the calculation of the burden estimates. But the methodology for calculation of the weights focuses only on physical impairment and lacks the perspective of the patient. In this study, we systematically reviewed the literature and performed an individual patient data meta-analysis for revising the disability weights for leprosy using domain scores from health-related quality of life instruments. The domains of these instruments cover all aspects of disability from a patient's perspective. We found that the revised weights were considerably higher than the current weights, and were more reflective of the actual disability caused by leprosy. We also found that for individuals without any severe disability due to leprosy (grade 0), they still experience comparable suffering. Revision of the current disability weights and inclusion of the disability caused in grade 0 individuals will contribute towards better estimation of the global burden of leprosy. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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29. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015

Author

Wang, Haidong, Wolock, Tim M, Carter, Austin, Nguyen, Grant, Kyu, Hmwe Hmwe, Gakidou, Emmanuela, Hay, Simon I, Mills, Edward J, Trickey, Adam, Msemburi, William, Coates, Matthew M, Mooney, Meghan D, Fraser, Maya S, Sligar, Amber, Salomon, Joshua, Larson, Heidi J, Friedman, Joseph, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbas, Kaja M, Razek, Mohamed Magdy Abd El, Abd-Allah, Foad, Abdulle, Abdishakur M, Abera, Semaw Ferede, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M E, Abyu, Gebre Yitayih, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Adelekan, Ademola Lukman, Adofo, Koranteng, Adou, Arsène Kouablan, Ajala, Oluremi N, Akinyemiju, Tomi F, Akseer, Nadia, Lami, Faris Hasan Al, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K M, Alasfoor, Deena, Aldhahri, Saleh Fahed S, Aldridge, Robert William, Alegretti, Miguel Angel, Aleman, Alicia V, Alemu, Zewdie Aderaw, Alfonso-Cristancho, Rafael, Ali, Raghib, Alkerwi, Ala'a, Alla, François, Mohammad, Rajaa, Al-Raddadi, Salem, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amberbir, Alemayehu, Amegah, Adeladza Kofi, Ammar, Walid, Amrock, Stephen Marc, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Asghar, Rana Jawad, Assadi, Reza, Atique, Suleman, Atkins, Lydia S, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Bacha, Umar, Badawi, Alaa, Barac, Aleksandra, Bärnighausen, Till, Basu, Arindam, Bayou, Tigist Assefa, Bayou, Yibeltal Tebekaw, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Bennett, Derrick A, Bensenor, Isabela M, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhatia, Eesh, Bhutta, Zulfiqar A, Biadgilign, Sibhatu, Bikbov, Boris, Birlik, Sait Mentes, Bisanzio, Donal, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brown, Alexandria, Burch, Michael, Butt, Zahid A, Campuzano, Julio Cesar, Cárdenas, Rosario, Carrero, Juan Jesus, Castañeda-Orjuela, Carlos A, Rivas, Jacqueline Castillo, Catalá-López, Ferrán, Chang, Hsing-Yi, Chang, Jung-chen, Chavan, Laxmikant, Chen, Wanqing, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G, Cooper, Cyrus, Dahiru, Tukur, Damtew, Solomon Abrha, Dandona, Lalit, Dandona, Rakhi, das Neves, José, de Jager, Pieter, De Leo, Diego, Degenhardt, Louisa, Dellavalle, Robert P, Deribe, Kebede, Deribew, Amare, Des Jarlais, Don C, Dharmaratne, Samath D, Ding, Eric L, Doshi, Pratik Pinal, Doyle, Kerrie E, Driscoll, Tim R, Dubey, Manisha, Elshrek, Yousef Mohamed, Elyazar, Iqbal, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshrati, Babak, Esteghamati, Alireza, Faghmous, Imad D A, Farinha, Carla Sofia e Sa, Faro, Andre, Farvid, Maryam S, Farzadfar, Farshad, Fereshtehnejad, Seyed-Mohammad, Fernandes, Joao C, Fischer, Florian, Fitchett, Joseph Robert Anderson, Foigt, Nataliya, Fullman, Nancy, Fürst, Thomas, Gankpé, Fortuné Gbètoho, Gebre, Teshome, Gebremedhin, Amanuel Tesfay, Gebru, Alemseged Aregay, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Peter W, Ghiwot, Tsegaye Tewelde, Giroud, Maurice, Gishu, Melkamu Dedefo, Glaser, Elizabeth, Goenka, Shifalika, Goodridge, Amador, Gopalani, Sameer Vali, Goto, Atsushi, Gugnani, Harish Chander, Guimaraes, Mark D C, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Haagsma, Juanita, Hafezi-Nejad, Nima, Hagan, Holly, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Harun, Kimani M, Havmoeller, Rasmus, Hedayati, Mohammad T, Heredia-Pi, Ileana Beatriz, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Huang, Hsiang, Huang, John J, Iburg, Kim Moesgaard, Idrisov, Bulat T, Innos, Kaire, Iyer, Veena J, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jibat, Tariku, Jonas, Jost B, Kabir, Zubair, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karletsos, Dimitris, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Kayibanda, Jeanne Françoise, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Kengne, Andre Pascal, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khalil, Ibrahim, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khang, Young-Ho, Khubchandani, Jagdish, Kim, Yun Jin, Kinfu, Yohannes, Kivipelto, Miia, Kokubo, Yoshihiro, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kulkarni, Veena S, Kumar, G Anil, Lal, Dharmesh Kumar, Lam, Hilton, Lam, Jennifer O, Langan, Sinead M, Lansingh, Van C, Larsson, Anders, Leigh, James, Leung, Ricky, Li, Yongmei, Lim, Stephen S, Lipshultz, Steven E, Liu, Shiwei, Lloyd, Belinda K, Logroscino, Giancarlo, Lotufo, Paulo A, Lunevicius, Raimundas, Razek, Hassan Magdy Abd El, Mahdavi, Mahdi, Mahesh, P A, Majdan, Marek, Majeed, Azeem, Makhlouf, Carla, Malekzadeh, Reza, Mapoma, Chabila C, Marcenes, Wagner, Martinez-Raga, Jose, Marzan, Melvin Barrientos, Masiye, Felix, Mason-Jones, Amanda J, Mayosi, Bongani M, McKee, Martin, Meaney, Peter A, Mehndiratta, Man Mohan, Mekonnen, Alemayehu B, Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J, Mhimbira, Francis Apolinary, Miller, Ted R, Mikesell, Joseph, Mirarefin, Mojde, Mohammad, Karzan Abdulmuhsin, Mohammed, Shafiu, Mokdad, Ali H, Monasta, Lorenzo, Moradi-Lakeh, Maziar, Mori, Rintaro, Mueller, Ulrich O, Murimira, Brighton, Murthy, Gudlavalleti Venkata Satyanarayana, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nash, Denis, Nawaz, Haseeb, Nejjari, Chakib, Ngalesoni, Frida Namnyak, de Dieu Ngirabega, Jean, Nguyen, Quyen Le, Nisar, Muhammad Imran, Norheim, Ole F, Norman, Rosana E, Nyakarahuka, Luke, Ogbo, Felix Akpojene, Oh, In-Hwan, Ojelabi, Foluke Adetola, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Ota, Erika, Park, Hye-Youn, Park, Jae-Hyun, Patil, Snehal T, Patten, Scott B, Paul, Vinod K, Pearson, Katherine, Peprah, Emmanuel Kwame, Pereira, David M, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Pillay, Julian David, Plass, Dietrich, Polinder, Suzanne, Pourmalek, Farshad, Prokop, David M, Qorbani, Mostafa, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rana, Saleem M, Rao, Paturi Vishnupriya, Remuzzi, Giuseppe, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roy, Ambuj, Ruhago, George Mugambage, Saeedi, Mohammad Yahya, Sagar, Rajesh, Saleh, Muhammad Muhammad, Sanabria, Juan R, Santos, Itamar S, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Sawhney, Monika, Schutte, Aletta E, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shaikh, Masood Ali, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shen, Jiabin, Shibuya, Kenji, Shin, Hwashin Hyun, Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, Diego Augusto Santos, Silveira, Dayane Gabriele Alves, Simard, Edgar P, Sindi, Shireen, Singh, Jasvinder A, Singh, Om Prakash, Singh, Prashant Kumar, Skirbekk, Vegard, Sliwa, Karen, Soneji, Samir, Sorensen, Reed J D, Soriano, Joan B, Soti, David O, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Steel, Nicholas, Sunguya, Bruno F, Swaminathan, Soumya, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Talongwa, Roberto Tchio, Tavakkoli, Mohammad, Taye, Bineyam, Tedla, Bemnet Amare, Tekle, Tesfaye, Shifa, Girma Temam, Temesgen, Awoke Misganaw, Terkawi, Abdullah Sulieman, Tesfay, Fisaha Haile, Tessema, Gizachew Assefa, Thapa, Kiran, Thomson, Alan J, Thorne-Lyman, Andrew L, Tobe-Gai, Ruoyan, Topor-Madry, Roman, Towbin, Jeffrey Allen, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimparis, Nikolaos, Tura, Abera Kenay, Ukwaja, Kingsley Nnanna, Uneke, Chigozie Jesse, Uthman, Olalekan A, Venketasubramanian, N, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wang, Linhong, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Westerman, Ronny, Wijeratne, Tissa, Wilkinson, James D, Wiysonge, Charles Shey, Wolfe, Charles D A, Won, Sungho, Wong, John Q, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yano, Yuichiro, Yaseri, Mehdi, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Yu, Shicheng, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhang, Hao, Zhao, Yong, Zodpey, Sanjay, Zoeckler, Leo, Zuhlke, Liesl Joanna, Lopez, Alan D, Murray, Christopher J L, Health Services Management & Organisation (HSMO), Public Health, and İç Hastalıkları

Subjects
Time Factors, Incidence, Immunology, HIV Infections, Articles, Global Health, Article, CD4 Lymphocyte Count, Global Burden of Disease, Young Adult, Infectious Diseases, SDG 3 - Good Health and Well-being, Seroepidemiologic Studies, Antiretroviral Therapy, Highly Active, Prevalence, Humans
Abstract

Background: timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.Methods: for countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification.Findings: global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1–3·4 million). Annual incidence has stayed relatively constant at about 2·6 million per year (range 2·5–2·8 million) since 2005, after a period of fast decline between 1997 and 2005. The number of people living with HIV/AIDS has been steadily increasing and reached 38·8 million (95% UI 37·6–40·4 million) in 2015. At the same time, HIV/AIDS mortality has been declining at a steady pace, from a peak of 1·8 million deaths (95% UI 1·7–1·9 million) in 2005, to 1·2 million deaths (1·1–1·3 million) in 2015. We recorded substantial heterogeneity in the levels and trends of HIV/AIDS across countries. Although many countries have experienced decreases in HIV/AIDS mortality and in annual new infections, other countries have had slowdowns or increases in rates of change in annual new infections.Interpretation: scale-up of ART and prevention of mother-to-child transmission has been one of the great successes of global health in the past two decades. However, in the past decade, progress in reducing new infections has been slow, development assistance for health devoted to HIV has stagnated, and resources for health in low-income countries have grown slowly. Achievement of the new ambitious goals for HIV enshrined in Sustainable Development Goal 3 and the 90-90-90 UNAIDS targets will be challenging, and will need continued efforts from governments and international agencies in the next 15 years to end AIDS by 2030.FundingBill & Melinda Gates Foundation, and National Institute of Mental Health and National Institute on Aging, National Institutes of Health

Published
2016

30. The global burden of disease study 2013: What does it mean for the NTDs?

Author

Herricks, Jennifer R., Hotez, Peter J., Wanga, Valentine, Coffeng, Luc E., Haagsma, Juanita A., Basáñez, María-Gloria, Buckle, Geoffrey, Budke, Christine M., Carabin, Hélène, Fèvre, Eric M., Fürst, Thomas, Halasa, Yara A., King, Charles H., Murdoch, Michele E., Ramaiah, Kapa D., Shepard, Donald S., Stolk, Wilma A., Undurraga, Eduardo A., Stanaway, Jeffrey D., and Naghavi, Mohsen

Subjects
TROPICAL medicine, DISEASE risk factors, DISEASES, MEDICAL climatology, GLOBAL burden of disease
Abstract

The article reports that the Global Burden of Disease Study (GBD) systematically quantifies the prevalence, morbidity, and mortality for hundreds of diseases, injuries, and risk factors of global health importance. For the neglected tropical diseases (NTDs), the GBD 2010 confirmed a high disease burden for the 17 major NTDs prioritized by the World Health Organization (WHO) as well as for selected conditions also recognized as NTDs.

Published
2017
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31. Estimating distributions of health state severity for the global burden of disease study.

Author

Burstein, Roy, Fleming, Tom, Haagsma, Juanita, Salomon, Joshua A., Vos, Theo, and Murray, Christopher J. L.

Subjects
CONFIDENCE intervals, LIFE skills, MENTAL illness, NOSOLOGY, REGRESSION analysis, RESEARCH funding, STATISTICAL sampling, WORLD health, SECONDARY analysis, SEVERITY of illness index, QUALITY-adjusted life years, MEDICAL coding, STATISTICAL models
Abstract

Background: Many major causes of disability in the Global Burden of Disease (GBD) study present with a range of severity, and for most causes finding population distributions of severity can be difficult due to issues of sparse data, inconsistent measurement, and need to account for comorbidities. We developed an indirect approach to obtain severity distributions empirically from survey data. Methods: Individual-level data were used from three large population surveys from the US and Australia that included self-reported prevalence of major diseases and injuries as well as generic health status assessments using the 12-Item Short Form Health Survey (SF-12). We developed a mapping function from SF-12 scores to GBD disability weights. Mapped scores for each individual respondent were regressed against the reported diseases and injuries using a mixed-effects model with a logit-transformed response variable. The regression outputs were used to predict comorbidity-corrected health-state weights for the group of individuals with each condition. The distribution of these comorbidity-corrected weights were used to estimate the fraction of individuals with each condition falling into different GBD severity categories, including asymptomatic (implying disability weight of zero). Results: After correcting for comorbid conditions, all causes analyzed had some proportion of the population in the asymptomatic category. For less severe conditions, such as alopecia areata, we estimated that 44.1 % [95 % CI: 38.7 %-49.4 %] were asymptomatic while 28.3 % [26.8 %-29.6 %] of anxiety disorders had asymptomatic cases. For 152 conditions, full distributions of severity were estimated. For anxiety disorders for example, we estimated the mean population proportions in the mild, moderate, and severe states to be 40.9 %, 18.5 %, and 12.3 % respectively. Thirty-seven of the analyzed conditions were used in the GBD 2013 estimates and are reported here. Conclusion: There is large heterogeneity in the disabling severity of conditions among individuals. The GBD 2013 approach allows explicit accounting for this heterogeneity in GBD estimates. Existing survey data that have collected health status together with information on the presence of a series of comorbid conditions can be used to fill critical gaps in the information on condition severity while correcting for effects of comorbidity. Our ability to make these estimates may be limited by lack of geographic variation in the data and by the current methodology for disability weights, which implies that severity must be binned rather than expressed in as a full distribution. Future country-specific data collection efforts will be needed to advance this research. [ABSTRACT FROM AUTHOR]

Published
2015
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32. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Naghavi, Mohsen, Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Arnlov, Johan, Afshin, Ashkan, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Aiyar, Sneha, Al-Eyadhy, Ayman, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addis, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M., Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H., Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T., Anwari, Palwasha, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W., Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Paulina, Beatriz, Quintanilla, Ayala, Bejot, Yannick, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A., Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lars, Barrero, Lope H., Baune, Bernhard T., Bedi, Neeraj, Beghi, Ettore, Bekele, Bayu Begashaw, Bell, Michelle L., Bennett, James R., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Boris, Bisanzio, Donal, Bourne, Rupert R. A., Breitborde, Nicholas J. K., Negesa, Lemma, Bulto, Bulto, Bumgarner, Blair R., Butt, Zahid A., Cardenas, Rosario, Cahuana-Hurtado, Lucero, Cameron, Ewan, Cesar Campuzano, Julio, Car, Josip, Jesus Carrero, Juan, Carter, Austin, Casey, Daniel C., Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Charlson, Fiona J., Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Colombara, Danny, Cooper, Cyrus, Cowie, Benjamin C., Criqui, Michael H., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., das Neves, Jose, Davitoiu, Dragos V., Davletov, Kairat, de Courten, Barbora, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L., Djalalinia, Shirin, Huyen Phuc Do, Huyen Phuc Do, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R., Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Erskine, Holly E., Eskandarieh, Sharareh, Esteghamati, Alireza, Ermakov, Sergey P., Estep, Kara, E Sa Farinha, Carla Sofia, Faro, Andre, Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Joao C., Ferrari, Alize J., Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D., Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Furst, Thomas, Furtado, Joao M., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M., Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W., Gillum, Richard F., Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Giussani, Giorgia, Godwin, William W., Gold, Audra L., Goldberg, Ellen M., Gona, Philimon N., Gopalani, Sameer Vali, Gouda, Hebe N., Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Prakash C., Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Simon I., He, Fei, Hedayati, Mohammad T., Henry, Nathaniel J., Beatriz Heredia-Pi, Ileana, Herteliu, Claudiu, Hoek, Hans W., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Jurisson, Mikk, Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayaraman, Sudha P., Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O., Johnson, Sarah Charlotte, Jonas, Jost B., Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, Andre, Karimi, Seyed M., Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kieling, Christian, Kievlan, Daniel, Kim, Daniel, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A., Kosen, Soewarta, Koul, Parvaiz A., Koyanagi, Ai, Defo, Barthelemy Kuate, Kulikoff, Xie Rachel, Kumar, G. Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lambert, Nkurunziza, Lan, Qing, Lansingh, Van C., Larsson, Anders, Lee, Paul H., Leigh, James, Leung, Janni, Levi, Miriam, Li, Yongmei, Kappe, Darya Li, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S., Liu, Angela, Liu, Patrick Y., Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lucas, Timothy C. D., Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R., Abd el Razek, Mohammed Magdy, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C., Marczak, Laurie B., Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J., Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A., Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A., Meretoja, Atte, Meretoja, Tuomo J., Millear, Anoushka, Miller, Ted R., Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M., Misganaw, Awoke, Mishra, Shiva Raj, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H., Mola, Glen Liddell D., Mollenkopf, Sarah K., Molokhia, Mariam, Monasta, Lorenzo, Montanez Hernandez, Julio C., Montico, Marcella, Mooney, Meghan D., Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morrison, Shane D., Morozoff, Chloe, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B., Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramos, Nasher, Jamal T., Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Cuong Tat Nguyen, Cuong Tat Nguyen, Grant Nguyen, Grant Nguyen, Minh Nguyen, Minh Nguyen, Quyen Le Nguyen, Quyen Le Nguyen, Trang Huyen Nguyen, Trang Huyen Nguyen, Nichols, Emma, Ningrum, Dina Nur Anggraini, Vuong Minh Nong, Vuong Minh Nong, Noubiap, Jean Jacques N., Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Pa, Mahesh, Pacella, Rosana E., Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B., Patton, George C., Paudel, Deepak, Paulson, Katherine, Pereira, David M., Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M., Pinho, Christine, Plass, Dietrich, Pletcher, Martin A., Polinder, Suzanne, Postma, Maarten J., Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C., Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E., Rehm, Jurgen, Reiner, Robert C., Reitsma, Marissa B., Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Ruhago, George Mugambage, Saadat, Rizwan S. A. Soheil, Sachdev, Perminder S., Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A., Samy, Abdallah M., Sanabria, Juan Ramon, Dolores Sanchez-Nino, Maria, Santomauro, Damian, Santos, Itamar S., Milicevic, Milena M. Santric, Sartorius, Benn, Satpathy, Maheswar, Shahraz, Saeid, Schmidt, Maria Ines, Schneider, Ione J. C., Schulhofer-Wohl, Sam, Schutte, Aletta E., Schwebel, David C., Schwendicke, Falk, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya Anne, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Islam, Sheikh Mohammed Shariful, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shi, Peilin, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G., Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, Joao Pedro, Singh, Abhishek, Singh, Jasvinder A., Skiadaresi, Eirini, Sligar, Amber, Smith, Alison, Smith, David L., Smith, Mari, Sobaih, Badr H. A., Soneji, Samir, Sorensen, Reed J. D., Soriano, Joan B., Sreeramareddy, Chandrashekhar T., Srinivasan, Vinay, Stanaway, Jeffrey D., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F., Sur, Patrick J., Swaminathan, Soumya, Sykes, Bryan L., Tabares-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S., Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J. S., Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E., Thompson, Alex H., Thomson, Alan J., Thrift, Amanda G., Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Bach Xuan Tran, Bach Xuan Tran, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Updike, Rachel, Uthman, Olalekan A., Uzochukwu, Benjamin S. Chudi, van Boven, Job F. M., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T., Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G., Weiss, Daniel J., Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A., Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D. A., Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Denis, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Lopez, Alan D., Murray, Christopher J. L., Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Miloud Taki Eddine, Aichour, Ibtihel, Aiyar, Sneha, Alahdab, Fare, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addi, Al-Eyadhy, Ayman, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, Françoi, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lar, Barrero, Lope H, Baune, Bernhard T, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Bori, Bisanzio, Donal, Bourne, Rupert R A, Breitborde, Nicholas J K, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Car, Josip, Cárdenas, Rosario, Carrero, Juan Jesu, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charlson, Fiona J, Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Christopher, Devasahayam Jesuda, Ciobanu, Liliana G, Cirillo, Massimo, Cohen, Aaron J, Colombara, Danny, Cooper, Cyru, Cowie, Benjamin C, Criqui, Michael H, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, das Neves, José, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, Defo, Barthelemy Kuate, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R, Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Erskine, Holly E, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Farinha, Carla Sofia e Sa, Faro, André, Farzadfar, Farshad, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C, Ferrari, Alize J, Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D, Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Fürst, Thoma, Furtado, Joao M, Gakidou, Emmanuela, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W, Gillum, Richard F, Giroud, Maurice, Giussani, Giorgia, Godwin, William W, Gold, Audra L, Goldberg, Ellen M, Gona, Philimon N, Gopalani, Sameer Vali, Gouda, Hebe N, Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A, Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmu, Hay, Simon I, He, Fei, Hedayati, Mohammad T, Henry, Nathaniel J, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, André, Karimi, Seyed M, Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Khosravi, Ardeshir, Khubchandani, Jagdish, Kiadaliri, Aliasghar Ahmad, Kieling, Christian, Kievlan, Daniel, Kim, Yun Jin, Kim, Daniel, Kimokoti, Ruth W, Kinfu, Yohanne, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kulikoff, Xie Rachel, Kumar, G Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Tea Lallukka Nkurunziza, Lan, Qing, Lansingh, Van C, Larsson, Ander, Lee, Paul H, Leigh, Jame, Leung, Janni, Levi, Miriam, Li, Yongmei, Li Kappe, Darya, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S, Liu, Patrick Y, Liu, Angela, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Timothy C D, Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R, Magdy Abd El Razek, Mohammed, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C, Marczak, Laurie B, Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mohamed, Ibrahim Abdelmageem, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H, Mola, Glen Liddell D, Mollenkopf, Sarah K, Molokhia, Mariam, Monasta, Lorenzo, Montañez, Julio C, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morozoff, Chloe, Morrison, Shane D, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murray, Christopher J L, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B, Naghavi, Mohsen, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramo, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Noubiap, Jean Jacques N, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, PA, Mahesh, Pacella, Rosana E, Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pereira, David M, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M, Pinho, Christine, Plass, Dietrich, Pletcher, Martin A, Polinder, Suzanne, Postma, Maarten J, Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Radfar, Amir, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C, Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E, Rehm, Jürgen, Reiner, Robert C, Reitsma, Marissa B, Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Ruhago, George Mugambage, SA, Rizwan, Saadat, Soheil, Sachdev, Perminder S, Sadat, Nafi, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A, Samy, Abdallah M, Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolore, Santomauro, Damian, Santos, Itamar S, Santric Milicevic, Milena M, Sartorius, Benn, Satpathy, Maheswar, Schmidt, Maria Inê, Schneider, Ione J C, Schulhofer-Wohl, Sam, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya Anne, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G, Sigfusdottir, Inga Dora, Silpakit, Nari, Silva, João Pedro, Singh, Jasvinder A, Singh, Abhishek, Skiadaresi, Eirini, Sligar, Amber, Smith, David L, Smith, Alison, Smith, Mari, Sobaih, Badr H A, Soneji, Samir, Sorensen, Reed J D, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steel, Nichola, Stein, Dan J, Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S, Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J.S., Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E, Thompson, Alex H, Thomson, Alan J, Thrift, Amanda G, Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thoma, Tsoi, Derrick, Tyrovolas, Stefano, Ukwaja, Kingsley N, Undurraga, Eduardo A, Updike, Rachel, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, van Boven, Job F M, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T, Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A, Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D A, Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Deni, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Giref, Ababi Zergaw, Rafay, Anwar, Tuzcu, Emin Murat, Ermakov, Sergey Petrovich, Shi, Peilin, Gupta, Parkash C, Erasmus MC other, Public Health, Neurosciences, Viðskiptadeild (HR), School of Business (RU), Háskólinn í Reykjavík, Reykjavik University, Mohsen, Naghavi, Amanuel, Alemu, Abajobir, Cristiana, Abbafati, Kaja, M, Abbas, Foad, Abd Allah, Semaw, Ferede, Abera, Victor, Aboyan, Olatunji, Adetokunboh, Johan, Ärnlöv, Ashkan, Afshin, Anurag, Agrawal, Aliasghar, Ahmad, Kiadaliri, Alireza, Ahmadi, Muktar, Beshir, Ahmed, Amani, Nidhal, Aichour, Ibtihel, Aichour, Miloud, Taki, Eddine, Aichour, Sneha, Aiyar, Ayman, Al Eyadhy, Fares, Alahdab, Ziyad, Al Aly, Khurshid, Alam, Noore, Alam, Tahiya, Alam, Kefyalew, Addi, Alene, Syed, Danish, Ali, Reza, Alizadeh Navaei, Juma, M, Alkaabi, Ala’A, Alkerwi, François, Alla, Peter, Allebeck, Christine, Allen, Rajaa, Al Raddadi, Ubai, Alsharif, Khalid, A, Altirkawi, Nelson, Alvis Guzman, Azmeraw, T, Amare, Erfan, Amini, Walid, Ammar, Yaw, Ampem, Amoako, Nahla, Anber, Hjalte, H, Andersen, Catalina, Liliana, Andrei, Sofia, Androudi, Hossein, Ansari, Carl, Abelardo, T, Antonio, Palwasha, Anwari, Megha, Arora, Al, Artaman, Krishna, Kumar, Aryal, Hamid, Asayesh, Solomon, W, Asgedom, Tesfay, Mehari, Atey, Leticia, Avila Burgo, Euripide, Frinel, G, Arthur, Avokpaho, Ashish, Awasthi, Beatriz, Paulina, Ayala, Quintanilla, Yannick, Béjot, Tesleem, Kayode, Babalola, Umar, Bacha, Kalpana, Balakrishnan, Aleksandra, Barac, Miguel, A, Barboza, Suzanne, L, Barker, Collo, Simon, Barquera, Lars, Barregard, Lope, H, Barrero, Bernhard, T, Baune, Neeraj, Bedi, Ettore, Beghi, Bayu, Begashaw, Bekele, Michelle, L, Bell, James, R, Bennett, Isabela, M, Bensenor, Adugnaw, Berhane, Eduardo, Bernabé, Balem, Demtsu, Betsu, Mircea, Beuran, Samir, Bhatt, Sibhatu, Biadgilign, Kelly, Bienhoff, Boris, Bikbov, Donal, Bisanzio, Rupert, R, A, Bourne, Nicholas, J, K, Breitborde, Lemma, Negesa, Bulto, Bulto, Blair, R, Bumgarner, Zahid, A, Butt, Rosario, Cárdena, Lucero, Cahuana Hurtado, Ewan, Cameron, Julio, Cesar, Campuzano, Josip, Car, Juan, Jesu, Carrero, Austin, Carter, Daniel, C, Casey, Carlo, A, Castañeda, Orjuela, Ferrán, Catalá López, Fiona, J, Charlson, Chioma, Ezinne, Chibueze, Odgerel, Chimed Ochir, Vesper, Hichilombwe, Chisumpa, Abdulaal, A, Chitheer, Devasahayam, Jesuda, Christopher, Liliana, G, Ciobanu, Aaron, J, and Cohen

Subjects
Dánarmein, Male, Heilsufar, Dánartíðni, Newborn infants, Lífslíkur, Life expectancy, Communicable diseases, Global Health, Global Burden of Disease, Disasters, Pregnancy, Cause of Death, Psychology, Child, Konur, Aged, 80 and over, Ungbörn, CLIMATE-CHANGE, PLASMODIUM-FALCIPARUM, Kransæðasjúkdómar, Global burden of disease/statistics and numerical data, Medicine (all), Men, Þjóðir, Öndunarfærasjúkdómar, 11 Medical And Health Sciences, Middle Aged, Nutrition Disorders, PREVALENCE, Coronary heart disease, Smitsjúkdómar, Death, Suicide, Cardiovascular diseases, Sálfræði, World health, Child, Preschool, Nýburar, Female, GBD, mortality, Infants, Life Sciences & Biomedicine, Age distribution, Global Health Metrics, Adult, Diarrhea, AFRICA, HUMAN HEALTH, Adolescent, GBD, UNITED-STATES, Socioeconomic factors, Communicable Diseases, Young Adult, Age Distribution, Heilbrigðisvísindi, Medicine, General & Internal, General & Internal Medicine, Humans, QUALITY, Women, Nutrition disorders, INCOME COUNTRIES, Mortality, Noncommunicable Diseases, Aged, Science & Technology, Infant, Newborn, Infant, Respiratory infections, Næringarskortur, ALCOHOL POLICY, mortality, Malaria, Pregnancy Complications, Socioeconomic Factors, Áverkar, Karlar, Wounds and Injuries, Félagshagfræði, Accidental Falls, Cause of death/trends, RESISTANCE
Abstract

Correction: Group Author(s): GBD 2016 Causes Death LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017 Group Author(s): GBD 2016 Dis Injury Incidence LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specific causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specific deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72.3% (95% uncertainty interval [UI] 71.2-73.2) of deaths in 2016 with 19.3% (18.5-20.4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8.43% (8.00-8.67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16-age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1.80 million deaths (95% UI 1.59 million to 1.89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL significantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2.89%); the median annualised rate of change for all other causes was lower (a decrease of 1.59%) during the same interval. Globally, the five leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a finer level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and conflict and terrorism. Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially increasing costs to health systems., Bill & Melinda Gates Foundation.

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33. Disability-Adjusted Life Years Resulting from Ocular Injury among Deployed Service Members, 2001–2020.

Author

Travor, Mark D., Levine, Emily S., Catomeris, Andrew J., Purt, Boonkit, Gensheimer, William G., Justin, Grant A., Trevino, Jennifer D., Haagsma, Juanita A., Colyer, Marcus H., and Staudt, Amanda M.

Subjects
*MILITARY personnel, *VITAL statistics, *GLOBAL burden of disease, *VISION disorders, *LIFE tables, *LIFE expectancy, *OCULAR injuries, *FOREIGN bodies
Abstract

To quantify the burden of ocular injuries on deployed US service members by calculating disability-adjusted life years (DALYs). Retrospective, observational cohort study. US service members with ocular injuries sustained in combat zones from January 1, 2001 to May 19, 2020. Health states and duration of injuries were identified using data from the Defense and Veterans Eye Injury and Vision Registry. These health states were mapped to disability weights from the Global Burden of Disease (GBD) study. Average duration of injury or illness was calculated until remission or death. For the latter, life expectancy at age of sustaining injury, as identified from US Life Tables from the National Vital Statistics Reports 2020, was used. Using Defense Manpower Data Center reports capturing number of service members deployed per year, incidence rates were calculated for ocular injury and DALYs. Disability-adjusted life years of ocular injury. Seventeen thousand five hundred fifty-five patients sustained ocular injury that incurred DALYs. In total, these injuries resulted in 11 214 DALYs (average, 0.64 DALYs per included patient and 20.6 DALYs per 10 000 US service members per year). Severe impairment of distance vision (77.9%) and blindness (10.6%) were the primary contributors of DALYs. Although only 9.3% of patients sustained a permanent ocular injury, permanent disability accounted for 99.5% of total DALYs. The average yearly incidence rate of ocular injury was 32.0 cases per 10 000 US service members. Foreign body was the most frequent injury type (2754 occurrences), followed by abrasion (2419 occurrences) and multiple injury types (1429 occurrences). The most DALYs occurred in patients with multiple injury types (2485 DALYs), followed by abrasion (accounting for 725 DALYs) and foreign body (accounting for 461 DALYs). We report higher average DALYs per case ratio among US service members compared with the general population studied by the GBD study, highlighting the differences in probabilities of permanent injury between the two studies. Our study provides understanding of the impact of ocular injuries on active-duty service members and lays the groundwork for further research and interventions to mitigate their burden. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Author

Abbafati, C., Machado, D.B., Cislaghi, B., Salman, O.M., Karanikolos, M., McKee, M., Abbas, K.M., Brady, O.J., Larson, H.J., Trias-Llimós, S., Cummins, S., Langan, S.M., Sartorius, B., Hafiz, A., Jenabi, E., Mohammad Gholi Mezerji, N., Borzouei, S., Azarian, G., Khazaei, S., Abbasi, M., Asghari, B., Masoumi, S., Komaki, H., Taherkhani, A., Adabi, M., Abbasifard, M., Bazmandegan, G., Kamiab, Z., Vakilian, A., Anjomshoa, M., Mokari, A., Sabour, S., Shahbaz, M., Saeedi, R., Ahmadieh, H., Yousefinezhadi, T., Haj-Mirzaian, A., Nikbakhsh, R., Safi, S., Asgari, S., Irvani, S.N., Jahanmehr, N., Ramezanzadeh, K., Abbasi-Kangevari, M., Khayamzadeh, M., Abbastabar, H., Shirkoohi, R., Fazlzadeh, M., Janjani, H., Hosseini, M., Mansournia, M., Tohidinik, H., Bakhtiari, A., Fazaeli, A., Mousavi, S., Hasanzadeh, A., Nabavizadeh, B., Malekzadeh, R., Hashemian, M., Pourshams, A., Salimzadeh, H., Sepanlou, S.G., Afarideh, M., Esteghamati, A., Esteghamati, S., Ghajar, A., Heidari, B., Rezaei, N., Mohamadi, E., Rahimi-Movaghar, A., Rahim, F., Eskandarieh, S., Sahraian, M., Mohebi, F., Aminorroaya, A., Ebrahimi, H., Farzadfar, F., Mohajer, B., Pishgar, F., Saeedi Moghaddam, S., Shabani, M., Zarafshan, H., Abolhassani, H., Hafezi-Nejad, N., Heidari-Soureshjani, R., Abdollahi, M., Farahmand, M., Salamati, P., Mehrabi Nasab, E., Tajdini, M., Aghamir, S., Mirzaei, R., Dibaji Forooshani, Z., Khater, M.M., Abd-Allah, F., Abdelalim, A., Abualhasan, A., El-Jaafary, S.I., Hassan, A., Elsharkawy, A., Khater, A.M., Elhabashy, H.R., Salem, M.R.R., Salem, H., Sadeghi, M., Jafarinia, M., Amini-Rarani, M., Mohammadifard, N., Sarrafzadegan, N., Abdollahpour, I., Sarveazad, A., Tehrani-Banihashemi, A., Yoosefi Lebni, J., Manafi, N., Pazoki Toroudi, H., Dorostkar, F., Alipour, V., Sheikhtaheri, A., Arabloo, J., Azari, S., Ghashghaee, A., Rezapour, A., Naserbakht, M., Kabir, A., Mehri, F., Yousefifard, M., Asadi-Aliabadi, M., Babaee, E., Eshrati, B., Goharinezhad, S., Moradi-Lakeh, M., Abedi, P., Rashedi, V., Kumar, V., Elgendy, I.Y., Basu, S., Park, J., Pereira, A., Norheim, O.F., Eagan, A.W., Cahill, L.E., Sheikh, A., Abushouk, A.I., Kraemer, M.U.G., Thakur, B., Bärnighausen, T.W., Shrime, M.G., Abedi, A., Doshi, C.P., Abegaz, K.H., Geberemariyam, B.S., Aynalem, Y.A., Shiferaw, W.S., Abosetugn, A.E., Aboyans, V., Abrams, E.M., Gitimoghaddam, M., Kissoon, N., Stubbs, J.L., Brauer, M., Iyamu, I.O., Kopec, J.A., Pourmalek, F., Ribeiro, A.P., Malta, D.C., Gomez, R.S., Abreu, L.G., Abrigo, M.R.M., Almulhim, A.M., Dahlawi, S.M.A., Pottoo, F.H., Menezes, R.G., Alanzi, T.M., Alumran, A.K., Abu Haimed, A.K., Madadin, M., Alanezi, F.M., Abu-Gharbieh, E., Saddik, B., Abu-Raddad, L.J., Samy, A.M., El Nahas, N., Shalash, A.S., Nabhan, A.F., Kamath, A.M., Kassebaum, N.J., Aravkin, A.Y., Kochhar, S., Sorensen, R.J.D., Afshin, A., Burkart, K., Cromwell, E.A., Dandona, L., Dharmaratne, S.D., Gakidou, E., Hay, S.I., Kyu, H.H., Lopez, A.D., Lozano, R., Misganaw, A.T., Mokdad, A.H., Naghavi, M., Pigott, D.M., Reiner Jr, R.C., Roth, G.A., Stanaway, J.D., Vollset, S., Vos, T., Wang, H., Lim, S.S., Murray, C.J.L., Kalani, R., Ikuta, K.S., Cho, D.Y., Kneib, C.J., Crowe, C.S., Massenburg, B.B., Morrison, S.D., Acebedo, A., Adelson, J.D., Agesa, K.M., Alam, T., Albertson, S.B., Anderson, J.A., Antony, C.M., Ashbaugh, C., Assmus, M., Azhar, G., Balassyano, S., Bannick, M.S., Barthelemy, C.M., Bender, R.G., Bennitt, F.B., Bertolacci, G.J., Biehl, M.H., Bisignano, C., Boon-Dooley, A.S., Briant, P.S., Bryazka, D., Bumgarner, B.R., Callender, C.S., Cao, J., Castle, C.D., Castro, E., Causey, K., Cercy, K.M., Chalek, J., Charlson, F.J., Cohen, A.J., Comfort, H., Compton, K., Croneberger, A.J., Cruz, J.A., Cunningham, M., Dandona, R., Dangel, W.J., Dean, F.E., DeCleene, N.K., Deen, A., Degenhardt, L., Dingels, Z.V., Dippenaar, I.N., Dirac, M.A., Dolgert, A.J., Emmons-Bell, S., Estep, K., Farag, T., Feigin, V.L., Feldman, R., Ferrara, G., Ferrari, A.J., Fitzgerald, R., Force, L.M., Fox, J.T., Frank, T.D., Fu, W., Fukutaki, K., Fuller, J.E., Fullman, N., Galles, N.C., Gardner, W.M., Gershberg Hayoon, A., Goren, E., Gorman, T.M., Gottlich, H.C., Guo, G., Haddock, B., Hagins, H., Haile, L.M., Hamilton, E.B., Han, C., Han, H., Harvey, J.D., Henny, K., Henrikson, H.J., Henry, N.J., Herbert, M.E., Hsiao, T., Huynh, C.K., Iannucci, V.C., Ippolito, H., Irvine, C.M.S., Jafari, H., Jahagirdar, D., James, S.L., Johnson, C.O., Johnson, S.C., Keller, C., Kemmer, L., Kendrick, P.J., Knight, M., Kocarnik, J.M., Krohn, K.J., Larson, S.L., Lau, K.M., Ledesma, J.R., Leever, A.T., LeGrand, K.E., Lescinsky, H., Lin, C., Liu, H., Liu, Z., Lo, J., Lu, A., Ma, J., Maddison, E.R., Manguerra, H., Marks, A., Martopullo, I., Mastrogiacomo, C.I., May, E.A., Mooney, M.D., Mosser, J.F., Mullany, E.C., Mumford, J., Munro, S.B., Nandakumar, V., Nguyen, J., Nguyen, M., Nichols, E., Nixon, M.R., Odell, C.M., Ong, K.L., Orji, A.U., Ostroff, S.M., Pasovic, M., Paulson, K.R., Pease, S.A., Pennini, A., Pierce, M., Pilz, T.M., Pletcher, M., Rao, P.C., Razo, C., Redford, S.B., Reinig, N., Reitsma, M.B., Rhinehart, P., Robalik, T., Roberts, S., Roberts, N.L.S., Rolfe, S., Sbarra, A.N., Schaeffer, L.E., Shackelford, K.A., Shadid, J., Sharara, F., Shaw, D.H., Sheena, B.S., Simpson, K.E., Smith, A., Spencer, C.N., Spurlock, E.E., Stark, B.A., Steiner, C., Steuben, K.M., Sylte, D.O., Tang, M., Taylor, H.J., Terrason, S., Thomson, A.M., Torre, A.E., Travillian, R., Troeger, C.E., Vongpradith, A., Walters, M.K., Wang, J., Watson, A., Watson, S., Whisnant, J.L., Whiteford, H.A., Wiens, K.E., Wilner, L.B., Wilson, S., Wool, E.E., Wozniak, S.S., Wu, J., Wulf Hanson, S., Wunrow, H., Xu, R., Yadgir, S., Yearwood, J.A., York, H.W., Yuan, C., Zhao, J.T., Zheng, P., Zimsen, S.R.M., Zlavog, B.S., Chang, A.Y., Oren, E., Buchbinder, R., Chin, K.L., Guo, Y., Polkinghorne, K.R., Thrift, A.G., Lee, S.W.H., Ackerman, I.N., Cicuttini, F.M., Li, S., Zaman, S., Suleria, H., Zhang, J., Cowie, B.C., Wijeratne, T., Patton, G.C., Sawyer, S.M., Adair, T., Meretoja, A., Adetokunboh, O.O., Adamu, A.A., Iwu, C.J., Parry, C.D.H., Seedat, S., Ndwandwe, D.E., Mahasha, P.W., Stein, D.J., Nnaji, C.A., Sambala, E.Z., Wiysonge, C.S., Adebayo, O.M., Ilesanmi, O.S., Owolabi, M.O., Adeoye, A.M., Adedeji, I.A., Adekanmbi, V., Ibitoye, S.E., John-Akinola, Y.O., Oluwasanu, M.M., Oghenetega, O.B., Akinyemi, R.O., Zandian, H., Adham, D., Zahirian Moghadam, T., Advani, S.M., Teagle, W.L., Braithwaite, D., Agasthi, P., Saadatagah, S., Afshari, M., Agardh, E.E., Allebeck, P., Danielsson, A., Deuba, K., Carrero, J.J., Mohammad, D.K., Fereshtehnejad, S., Ärnlöv, J., Nowak, C., Cederroth, C.R., Ahmadi, A., Pathak, A., Mills, E.J., Kurmi, O.P., Olagunju, A.T., Agarwal, G., Sathish, T., Aghaali, M., Mohammadbeigi, A., Agrawal, A., Ahmad, T., Ahmadi, K., Maleki, S., Naderi, M., Salahshoor, M.R., Pourmirza Kalhori, R., Almasi, A., Salimi, Y., Siabani, S., Ziapour, A., Barzegar, A., Khazaie, H., Kianipour, N., Amiri, F., 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Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Mastrogiacomo, Claudia I, Mathur, Manu Raj, May, Erin A, Mcalinden, Colm, Mcgrath, John J, Mckee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M, Meitei, Wahengbam Bigyananda, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R, Mills, Edward J, Milne, George J, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Dara K, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadbeigi, Abolfazl, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Hussen, Mohammed, Shafiu, Mohebi, Farnam, Mohseni Bandpei, Mohammad A, Mokari, Amin, Mokdad, Ali H, Momen, Natalie C, Monasta, Lorenzo, Mooney, Meghan D, Moradi, Ghobad, Moradi, Masoud, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Moreno Velásquez, Ilai, Morgado-da-Costa, Joana, Morrison, Shane Dougla, Mosser, Jonathan F, Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Musa, Kamarul Imran, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Nigatu, Yeshambel T, Nikbakhsh, Rajan, Nikpoor, Amin Reza, Nixon, Molly R, Nnaji, Chukwudi A, Nomura, Shuhei, Noubiap, Jean Jacque, Nouraei Motlagh, Soraya, Nowak, Christoph, Oţoiu, Adrian, Odell, Christopher M, Oh, In-Hwan, Oladnabi, Morteza, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omar Bali, Ahmed, Ong, Kanyin L, Onwujekwe, Obinna E, Ortiz, Alberto, Otstavnov, Nikita, Otstavnov, Stanislav S, Øverland, Simon, Owolabi, Mayowa O, P A, Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Park, Jame, Pasupula, Deepak Kumar, Patel, Jenil R, Patel, Sangram Kishor, Patton, George C, Paulson, Katherine R, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pereira, Alexandre, Pereira, David M, Perico, Norberto, Pigott, David M, Pilgrim, Thoma, Pilz, Tessa M, Piradov, Michael A, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourshams, Akram, Poznańska, Anna, Prada, Sergio I, Prakash, Sanjay, Preotescu, Liliana, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Ram, Pradhum, Ranabhat, Chhabi Lal, Rao, Sowmya J, Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawal, Lal, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Nima, Rezai, Mohammad sadegh, Rezapour, Aziz, Rickard, Jennifer, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostamian, Morteza, Rubagotti, Enrico, Rwegerera, Godfrey M, Sabour, Siamak, Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S Mohammad, Salahshoor, Mohammad Reza, Salama, Joseph S, Salamati, Payman, Salem, Marwa R Rashad, Salimi, Yahya, Salomon, Joshua A, Salz, Inbal, Samad, Zainab, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saylan, Mete, Schaeffer, Lauren E, Schiavolin, Silvia, Schwebel, David C, Schwendicke, Falk, Sekerija, Mario, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serván-Mori, Edson, Shabani, Mahsima, Shahabi, Saeed, Shahbaz, Mohammad, Shaheen, Amira A, Shaikh, Masood Ali, Shalash, Ali S, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomar, Sharafi, Zeinab, Sharara, Fablina, Sharma, Rajesh, Shaw, David H, Sheikh, Aziz, Shin, Jae Il, Shiri, Rahman, Shrime, Mark G, Shuval, Kerem, Siabani, Soraya, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santo, Simonetti, Biagio, Simpson, Kyle E, Singh, Jasvinder A, Skiadaresi, Eirini, Skryabin, Valentin Yurievich, Soheili, Amin, Sokhan, Anton, Sorensen, Reed J D, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Stockfelt, Leo, Stokes, Mark A, Stubbs, Jacob L, Sudaryanto, Agu, Sufiyan, Mu'awiyyah Babale, Suliankatchi Abdulkader, Rizwan, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Tadakamadla, Santosh Kumar, Taherkhani, Amir, Tang, Muming, Taveira, Nuno, Taylor, Heather Jean, Teagle, Whitney L, Tehrani-Banihashemi, Arash, Teklehaimanot, Berhane Fseha, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thomas, Nihal, Thrift, Amanda G, Titova, Mariya Vladimirovna, Tohidinik, Hamid Reza, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tovani-Palone, Marcos Roberto Roberto, Traini, Eugenio, Tran, Bach Xuan, Travillian, Ravensara, Trias-Llimós, Sergi, Truelsen, Thomas Clement, Tudor Car, Lorainne, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Vakilian, Alireza, Valdez, Pascual R, Valli, Alessandro, Vardavas, Constantine, Vasankari, Tommi Juhani, Vasconcelos, Ana Maria Nogale, Vasseghian, Yasser, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Vidale, Simone, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vujcic, Isidora S, Vukovic, Ana, Vukovic, Rade, Waheed, Yasir, Wallin, Mitchell Taylor, Walters, Magdalene K, Wang, Hongbo, Wang, Yuan-Pang, Watson, Stefanie, Wei, Jingkai, Weiss, Jordan, Weldesamuel, Girmay Teklay, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wiangkham, Taweewat, Wiens, Kirsten E, Wijeratne, Tissa, Wiysonge, Charles Shey, Wojtyniak, Bogdan, Wolfe, Charles D A, Wondmieneh, Adam Belay, Wool, Eve E, Wu, Ai-Min, Wu, Junjie, Xu, Gelin, Yamada, Tomohide, Yamagishi, Kazumasa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yearwood, Jamal A, Yeheyis, Tomas Y, Yilgwan, Christopher Sabo, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yoosefi Lebni, Javad, York, Hunter W, Younis, Mustafa Z, Younker, Theodore Patrick, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zakzuk, Josefina, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zhang, Zhi-Jiang, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, Murray, Christopher J L, Collaborators, GBD 2019 Demographics, GBD 2019 Demographics Collaborator, Violante FS, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Department of Earth Systems Analysis, Biomechanical Engineering, TechMed Centre, Biomolecular Nanotechnology, Research Methodology, Measurement and Data Analysis, Materials Science and Technology of Polymers, Inorganic Materials Science, MESA+ Institute, Biomedical and Environmental Sensorsystems, Mesoscale Chemical Systems, Faculty of Engineering Technology, Nonlinear Solid Mechanics, Digital Society Institute, Pervasive Systems, Nanobiophysics, Faculty of Geo-Information Science and Earth Observation, Multi Scale Mechanics, Engineering Fluid Dynamics, Physics of Complex Fluids, Developmental BioEngineering, Physics of Fluids, Elastomer Technology and Engineering, Medical Cell Biophysics, European Membrane Institute, Department of Earth Observation Science, Biomaterials Science and Technology, Sustainable Process Technology, Department of Urban and Regional Planning and Geo-Information Management, Department of Natural Resources, XUV Optics, Databases (Former), Department of Water Resources, Psychology, Health & Technology, Membrane Science & Technology, Department of Public Health, Clinicum, HUS Neurocenter, HUS Comprehensive Cancer Center, and Environmental Sciences

Subjects
Male, very elderly, Demographic transition, HALE, 030204 cardiovascular system & hematology, preschool child, Global Burden of Disease, Carga Global de Enfermedades, 0302 clinical medicine, newborn, Risk Factors, Surveys and Questionnaires, and Risk Factors Study, 80 and over, 030212 general & internal medicine, Birth Rate, Child, Migration, 11 Medical and Health Sciences, Aged, 80 and over, education.field_of_study, Injuries, Geography, Mortality rate, 1. No poverty, DEATH, Censuses, General Medicine, SDG 10 - Reduced Inequalities, Middle Aged, Demographic analysis, 3142 Public health care science, environmental and occupational health, 3. Good health, demographic analysis, Estilo de Vida Saludable, risk factor, Child, Preschool, Demography/statistics & numerical data, Global Burden of Diseases, Injuries, Risk Factors, Fertility, Mortality, Migration, Population, epidemiology, Female, A990 Medicine and Dentistry not elsewhere classified, CHILD-MORTALITY, Live Birth, Global Health Metrics, TRANSITION, demographics, GBD, fertility, mortality, hale, Adult, Adolescent, Total fertility rate, Population, Global Burden of Diseases, Injuries, and Risk Factors Study, Birth rate, 03 medical and health sciences, Young Adult, Life Expectancy, SDG 3 - Good Health and Well-being, General & Internal Medicine, SYSTEMATIC ANALYSIS, Demografía, Humans, Global Burden of Disease Study, human, Mortality, education, Preschool, Aged, Demography, Spatial Analysis, questionnaire, Infant, Newborn, Klinisk medicin, HIV, Infant, Global Burden of Diseases, sex-specific fertility, Live Birth/epidemiology, purl.org/pe-repo/ocde/ford#3.02.00 [https], MODEL, Fertilidad, Fertility, Demographic change, Life expectancy, NA, global disease burden, Clinical Medicine, population research
Abstract

Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10-14 and 50-54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2.72 (95% uncertainty interval [UI] 2.66-2.79) in 2000 to 2.31 (2.17-2.46) in 2019. Global annual livebirths increased from 134.5 million (131.5-137.8) in 2000 to a peak of 139.6 million (133.0-146.9) in 2016. Global livebirths then declined to 135.3 million (127.2-144.1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2.1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27.1% (95% UI 26.4-27.8) of global livebirths. Global life expectancy at birth increased from 67.2 years (95% UI 66.8-67.6) in 2000 to 73.5 years (72.8-74.3) in 2019. The total number of deaths increased from 50.7 million (49.5-51.9) in 2000 to 56.5 million (53.7-59.2) in 2019. Under-5 deaths declined from 9.6 million (9.1-10.3) in 2000 to 5.0 million (4.3-6.0) in 2019. Global population increased by 25.7%, from 6.2 billion (6.0-6.3) in 2000 to 7.7 billion (7.5-8.0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58.6 years (56.1-60.8) in 2000 to 63.5 years (60.8-66.1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

Published
2020

35. The low global burden of trichinellosis: evidence and implications.

Author

Devleesschauwer, Brecht, Praet, Nicolas, Speybroeck, Niko, Torgerson, Paul R., Haagsma, Juanita A., De Smet, Kris, Murrell, K. Darwin, Pozio, Edoardo, and Dorny, Pierre

Subjects
*TRICHINOSIS, *FOODBORNE diseases, *HEALTH risk assessment, *HEALTH & social status, *INTERNATIONAL cooperation on public health
Abstract

Trichinellosis is a cosmopolitan foodborne disease that may result in severe health disorders and even death. Despite international awareness of the public health risk associated with trichinellosis, current data on its public health impact are still lacking. Therefore we assessed, for the first known time, the global burden of trichinellosis using the Disability-Adjusted Life Year metric. The global number of Disability-Adjusted Life Years due to trichinellosis was estimated to be 76 per billion persons per year (95% credible interval: 38–129). The World Health Organization European Region was the main contributor to this global burden, followed by the WHO region of the Americas and the World Health Organization Western Pacific region. The global burden of trichinellosis is much lower than that of other foodborne parasitic diseases and is in sharp contrast to the high budget allocated to prevent the disease in many industrialised countries. To decrease the uncertainty around the current estimates, more knowledge is needed on the level of underreporting of clinical trichinellosis in different parts of the world. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
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36. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sorin Hostiuc, Shaun Wen Huey Lee, Jorge R. Ledesma, Carsten Flohr, Masoumeh Sadeghi, João Mauricio Castaldelli-Maia, Behzad Karami Matin, Cyrus Alinia, Mehdi Bohluli, Félix Carvalho, Yun Jin Kim, Catalina Liliana Andrei, Seyyed Meysam Mousavi, Bernhard T. Baune, Ehsan Ahmadpour, Dinh-Toi Chu, Beatrix Haddock, Gianfranco Alicandro, Vasily Vlassov, Mohammad Taghi Khodayari, Gianna Gayle Herrera Amul, Arash Tehrani-Banihashemi, Govinda Prasad Dhungana, Fereshteh Ansari, Michael K. Hole, Azeem Majeed, Iman Halvaei, Saqib Ali, Arianna Maever L. Amit, Tomas Y. Yeheyis, John S. Ji, Martin McKee, Jamileh Shadid, Leonardo Roever, Peng Jia, Ettore Beghi, Pablo M. Lavados, Young Eun Kim, Vahid Alipour, Sowmya J. Rao, Ahmad Daryani, Cathleen Keller, Ibrahim Abdollahpour, Nicole K. DeCleene, Ebrahim Babaee, Saman Esmaeilnejad, Boris Bikbov, William M. Gardner, Lydia M. Haile, Luca Ronfani, Azalea M. Thomson, Irena Ilic, Ruth W. Kimokoti, Yingxi Zhao, Guoqing Hu, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Nathaniel J. Henry, Brijesh Sathian, Daniel Kim, Peter Memiah, Mohammad Hadi Abbasi, Andrea Farioli, Zahra Kamiab, Bolajoko O. Olusanya, Matthew C. Doxey, Tommi Vasankari, Hamideh Salimzadeh, Luisa Sorio Flor, Priya Rathi, Shanshan Li, Tanvir M. Huda, Dillon O Sylte, Rosario Cárdenas, Agegnehu Bante, Helen Ippolito, Alyssa Acebedo, Jeffrey D. Stanaway, Anwar Faraj, João Pedro Silva, Amin Mousavi Khaneghah, Pushpendra Kumar, Sangram Kishor Patel, Josephine W. Ngunjiri, Holly E. Erskine, Eugene Sobngwi, Filippo Ariani, Shane D. Morrison, Mohammad Aghaali, Meghan D. Mooney, Vera Marisa Costa, Palash Chandra Banik, Rupak Desai, Ken Takahashi, Maigeng Zhou, Morteza Oladnabi, Bogdan Oancea, Daniela Ribeiro, Mohammad Farahmand, Irmina Maria Michalek, Yetunde O. John-Akinola, Khem Narayan Pokhrel, Emilie R Maddison, Syed Mohamed Aljunid, Damian G. Hoy, Hosni Salem, V. Prakash, Shuhei Nomura, Inga Dora Sigfusdottir, Anders Larsson, Sharareh Eskandarieh, Abdollah Mohammadian-Hafshejani, Somayeh Bohlouli, Joana Morgado-da-Costa, Siamak Sabour, Theo Vos, Han Yong Wunrow, Khaled Khatab, Alireza Zangeneh, Ann Kristin Knudsen, Marissa B Reitsma, Hannah J. Henrikson, Randah R. Hamadeh, Tuomo J. Meretoja, Ireneous N. Soyiri, Giuseppe Grosso, Ziyad Al-Aly, Taraneh Yousefinezhadi, Joseph L Ward, Roba Khundkar, Ricardo Santiago Gomez, Reza Malekzadeh, John J. McGrath, Sandra B. Munro, Shahin Soltani, Amy E. Peden, Rufus Akinyemi, Marcel Ausloos, Naohiro Yonemoto, Bogdan Wojtyniak, Ahmad Ghashghaee, Guilherme Borges, Sadia Bibi, Farhad Islami, Hamed Mirzaei, Mohammad Ali Sahraian, M. Ashworth Dirac, Hosna Janjani, Kairat Davletov, Hermann Brenner, Yuichiro Yano, Elissa M. Abrams, Ana Vukovic, Bartosz Miazgowski, Jobert Richie Nansseu, Jennifer O Lam, Mona Pathak, Leeberk Raja Inbaraj, Thirunavukkarasu Sathish, Asadollah Gholamian, Carlos A Castañeda-Orjuela, Babak Eshrati, Edgar Denova-Gutiérrez, Atte Meretoja, Lorenzo Monasta, Ronan A. Lyons, Neda Kianipour, Desalegn Getnet Demsie, Yasir Waheed, Desta Debalkie Atnafu, Davide Sattin, Kevin S Ikuta, Ghobad Moradi, Srinivas Goli, Krittika Bhattacharyya, Mika Kivimäki, Christopher Troeger, Jordi Alonso, Alireza Ahmadi, Navid Manafi, Caroline Stein, Songhomitra Panda-Jonas, Jason Nguyen, Moses K. Muriithi, Aziz Rezapour, Ismael R. Campos-Nonato, Adrian Pana, H. Dean Hosgood, Noore Alam, James L. Fisher, Mariam Molokhia, Susan F. Rumisha, Ernoiz Antriyandarti, Ayman Grada, Emma Nichols, Babak Asghari, André Luiz Sena Guimarães, Ferrán Catalá-López, Aletta E. Schutte, Fiona B. Bennitt, Maciej Banach, Antonio Biondi, Donal Bisanzio, Josip Car, Ronny Westerman, Shafiu Mohammed, Biniyam Sahiledengle Geberemariyam, Kenji Shibuya, Meghdad Pirsaheb, Milena Santric-Milicevic, Karen M. Tabb, Paula Moraga, Soheil Hassanipour, Hasan Yusefzadeh, Avina Vongpradith, Dara K. Mohammad, Ralph Maddison, Babak Moazen, Getachew Mullu Kassa, Rahman Shiri, Fernando Neves Hugo, Hmwe H Kyu, Zachary V Dingels, Florian Fischer, Valentin Yurievich Skryabin, Rafael Tabarés-Seisdedos, Massimo Cirillo, Nikita Otstavnov, Robert C. Reiner, Van C. Lansingh, Rodrigo Sarmiento-Suarez, Ashkan Afshin, Benjamin A Stark, Mohsen Abbasi-Kangevari, Natalie C. Galles, Behnam Heidari, Eun-Kee Park, Mohammad Ali Jahani, Suzanne Polinder, Mahalaqua Nazli Khatib, Farhad Jadidi-Niaragh, Amir Radfar, Mowafa Househ, Derrick A Bennett, Gaorui Guo, Hesam Ghiasvand, Taweewat Wiangkham, Tamás Joó, Cristiana Abbafati, Kathryn Mei Ming Lau, Anita K. Nandi, Miklós Szócska, Manasi Kumar, Eduardo A. Undurraga, Oladimeji M. Adebayo, Simon Yadgir, Victor Aboyans, Justin J. Lang, Catherine O. Johnson, Soewarta Kosen, Carla Sofia e.Sá Farinha, Marcos Roberto Tovani-Palone, Kamarul Imran Musa, Farshad Pourmalek, Kiomars Sharafi, Heather Orpana, Samuel B. Albertson, Mahdi Afshari, Nicholas J K Breitborde, Nelson J. Alvis-Zakzuk, Adrian Oţoiu, Iván Landires, Robert G. Weintraub, Kidanemaryam Berhe, André Faro, Sophia Emmons-Bell, Lauren E. Schaeffer, Alexandre C. Pereira, Mehdi Naderi, Yordanos Gizachew Yeshitila, Mehdi Hosseinzadeh, Arash Etemadi, Oleguer Plana-Ripoll, Theodore Patrick Younker, Joemer C. Maravilla, Alireza Ansari-Moghaddam, Borhan Mansouri, Narayanaswamy Venketasubramanian, Seyed Mohammad Kazem Aghamir, Linda Morales, Amanda Deen, Noushin Mohammadifard, Obinna Onwujekwe, Ai Koyanagi, Michele Nguyen, Chieh Han, Kiana Ramezanzadeh, Mika Shigematsu, Mohammed Shannawaz, Khurshid Alam, Javad Nazari, Bryan L. Sykes, Rajat Das Gupta, Stephen S Lim, Lingkan Barua, Zubair Kabir, Michael Brauer, Afarin Rahimi-Movaghar, Deepa Jahagirdar, Kaja Abbas, Gholamreza Bazmandegan, Mark A. Stokes, Rajaa Al-Raddadi, Kanyin L. Ong, Kate Causey, Ahmed Omar Bali, Matilde Leonardi, Jeffrey V. Lazarus, Wondimeneh Shibabaw Shiferaw, André Karch, Blair R. Bumgarner, Nelson Alvis-Guzman, Jennifer H MacLachlan, Saeed Amini, Parvaiz A Koul, Blessing J. Akombi, Ro Ting Lin, Dabere Nigatu, Alaa Badawi, Flavia M. Cicuttini, Deanna Anderlini, Claudio Alberto Dávila-Cervantes, Rupert R A Bourne, Tanuj Kanchan, Catherine P. Benziger, Tahiya Alam, M. Mofizul Islam, Muktar Omer Omer, Leila Zaki, Mehdi Mirzaei-Alavijeh, Inbal Salz, Katharine J Looker, Shiwei Liu, Fatemeh Amiri, Christopher R. Cederroth, Mitra Abbasifard, Hamidreza Pazoki Toroudi, Gbenga A. Kayode, Antonio Luiz Pinho Ribeiro, Krishna Kumar Aryal, Mu'awiyyah Babale Sufiyan, Mohamed M. 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L., Department of Public Health, Clinicum, Department of Neurosciences, HUS Comprehensive Cancer Center, Environmental Sciences, Public Health, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, GBD 2019 Diseases and Injuries Collaborator, Violante FS, Department of Earth Observation Science, Faculty of Geo-Information Science and Earth Observation, and UT-I-ITC-ACQUAL

Subjects
Male, Life expectancy, Disability-Adjusted Life Year, Diseases, Disease, communicable disease, systematic analysis, Global Burden of Disease, 0302 clinical medicine, 80 and over, Medicine, 10. No inequality, Child, 11 Medical and Health Sciences, injuries, Aged, 80 and over, education.field_of_study, Sjúkdómar, DEMENTIA, FALLS, General Medicine, Forvarnir, 3. Good health, Child, Preschool, Human, GBD, Population health, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Humans, Global Burden of Disease Study, education, Aged, Spatial Analysis, Global burden, Disability, Prevention, DISABILITY, Infant, Spatial Analysi, Mortality rate, Global Burden of Disease, Diseases, Injuries, Systematic analysis, PREVENTION, Years of potential life lost, Risk factors, Disease study, ITC-ISI-JOURNAL-ARTICLE, RISK-FACTORS, Clinical Medicine, RA, Demography, Fötlun, Dánartíðni, Áhættuþættir, 030204 cardiovascular system & hematology, Risk Factors, Cause of Death, Global health, 030212 general & internal medicine, 1. No poverty, Disability-Adjusted Life Years, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, 3142 Public health care science, environmental and occupational health, Adolescent, Adult, Age Distribution, Female, Infant, Newborn, Young Adult, Lýðheilsa, CLINICAL-TRIALS, Population, Settore MED/01 - Statistica Medica, diseases, ITC-HYBRID, Heilbrigðisvísindi, General & Internal Medicine, Mortality, Preschool, Disease burden, business.industry, Risk Factor, Klinisk medicin, Newborn, purl.org/pe-repo/ocde/ford#3.02.00 [https], Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Áverkar, Systematic analysis, NA, business
Abstract

Publisher's version (útgefin grein), Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990-2010 time period, with the greatest annualised rate of decline occurring in the 0-9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10-24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10-24 years were also in the top ten in the 25-49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50-74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd., Research reported in this publication was supported by the Bill & Melinda Gates Foundation; the University of Melbourne; Queensland Department of Health, Australia; the National Health and Medical Research Council, Australia; Public Health England; the Norwegian Institute of Public Health; St Jude Children's Research Hospital; the Cardiovascular Medical Research and Education Fund; the National Institute on Ageing of the National Institutes of Health (award P30AG047845); and the National Institute of Mental Health of the National Institutes of Health (award R01MH110163). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. The authors alone are responsible for the views expressed in this Article and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated, the National Health Service (NHS), the National Institute for Health Research (NIHR), the UK Department of Health and Social Care, or Public Health England; the United States Agency for International Development (USAID), the US Government, or MEASURE Evaluation; or the European Centre for Disease Prevention and Control (ECDC). This research used data from the Chile National Health Survey 2003, 2009-10, and 2016-17. The authors are grateful to the Ministry of Health, the survey copyright owner, for allowing them to have the database. All results of the study are those of the authors and in no way committed to the Ministry. The Costa Rican Longevity and Healthy Aging Study project is a longitudinal study by the University of Costa Rica's Centro Centroamericano de Poblacion and Instituto de Investigaciones en Salud, in collaboration with the University of California at Berkeley. The original pre-1945 cohort was funded by the Wellcome Trust (grant 072406), and the 1945-55 Retirement Cohort was funded by the US National Institute on Aging (grant R01AG031716). The principal investigators are Luis Rosero-Bixby and William H Dow and co-principal investigators are Xinia Fernandez and Gilbert Brenes. The accuracy of the authors' statistical analysis and the findings they report are not the responsibility of ECDC. ECDC is not responsible for conclusions or opinions drawn from the data provided. ECDC is not responsible for the correctness of the data and for data management, data merging and data collation after provision of the data. ECDC shall not be held liable for improper or incorrect use of the data. The Health Behaviour in School-Aged Children (HBSC) study is an international study carried out in collaboration with WHO/EURO. The international coordinator of the 1997-98, 2001-02, 2005-06, and 2009-10 surveys was Candace Currie and the databank manager for the 1997-98 survey was Bente Wold, whereas for the following surveys Oddrun Samdal was the databank manager. A list of principal investigators in each country can be found on the HBSC website. Data used in this paper come from the 2009-10 Ghana Socioeconomic Panel Study Survey, which is a nationally representative survey of more than 5000 households in Ghana. The survey is a joint effort undertaken by the Institute of Statistical, Social and Economic Research (ISSER) at the University of Ghana and the Economic Growth Centre (EGC) at Yale University. It was funded by EGC. ISSER and the EGC are not responsible for the estimations reported by the analysts. The Palestinian Central Bureau of Statistics granted the researchers access to relevant data in accordance with license number SLN2014-3-170, after subjecting data to processing aiming to preserve the confidentiality of individual data in accordance with the General Statistics Law, 2000. The researchers are solely responsible for the conclusions and inferences drawn upon available data. Data for this research was provided by MEASURE Evaluation, funded by USAID. The authors thank the Russia Longitudinal Monitoring Survey, conducted by the National Research University Higher School of Economics and ZAO Demoscope together with Carolina Population Center, University of North Carolina at Chapel Hill and the Institute of Sociology, Russia Academy of Sciences for making data available. This paper uses data from the Bhutan 2014 STEPS survey, implemented by the Ministry of Health with the support of WHO; the Kuwait 2006 and 2014 STEPS surveys, implemented by the Ministry of Health with the support of WHO; the Libya 2009 STEPS survey, implemented by the Secretariat of Health and Environment with the support of WHO; the Malawi 2009 STEPS survey, implemented by Ministry of Health with the support of WHO; and the Moldova 2013 STEPS survey, implemented by the Ministry of Health, the National Bureau of Statistics, and the National Center of Public Health with the support of WHO. This paper uses data from Survey of Health, Ageing and Retirement in Europe (SHARE) Waves 1 (DOI:10.6103/SHARE. w1.700), 2 (10.6103/SHARE.w2.700), 3 (10.6103/SHARE.w3.700), 4 (10.6103/SHARE.w4.700), 5 (10.6103/SHARE.w5.700), 6 (10.6103/SHARE.w6.700), and 7 (10.6103/SHARE.w7.700); see Borsch-Supan and colleagues (2013) for methodological details. The SHARE data collection has been funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193, COMPARE: CIT5-CT-2005-028857, SHARELIFE: CIT4-CT-2006-028812), FP7 (SHARE-PREP: GA N degrees 211909, SHARE-LEAP: GA N degrees 227822, SHARE M4: GA N degrees 261982) and Horizon 2020 (SHARE-DEV3: GA N degrees 676536, SERISS: GA N degrees 654221) and by DG Employment, Social Affairs & Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C), and from various national funding sources is gratefully acknowledged. This study has been realised using the data collected by the Swiss Household Panel, which is based at the Swiss Centre of Expertise in the Social Sciences. The project is financed by the Swiss National Science Foundation. The United States Aging, Demographics, and Memory Study is a supplement to the Health and Retirement Study (HRS), which is sponsored by the National Institute of Aging (grant number NIA U01AG009740). It was conducted jointly by Duke University and the University of Michigan. The HRS is sponsored by the National Institute on Aging (grant number NIA U01AG009740) and is conducted by the University of Michigan. This paper uses data from Add Health, a program project designed by J Richard Udry, Peter S Bearman, and Kathleen Mullan Harris, and funded by a grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 17 other agencies. Special acknowledgment is due to Ronald R Rindfuss and Barbara Entwisle for assistance in the original design. Information on how to obtain the Add Health data files is available on the Add Health website. No direct support was received from grant P01-HD31921 for this analysis. The data reported here have been supplied by the United States Renal Data System. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy or interpretation of the US Government. Collection of data for the Mozambique National Survey on the Causes of Death 2007-08 was made possible by USAID under the terms of cooperative agreement GPO-A-00-08-000_D3-00. This manuscript is based on data collected and shared by the International Vaccine Institute (IVI) from an original study IVI conducted. L G Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Brazil; finance code 001) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, a Brazilian funding agency). I N Ackerman was supported by a Victorian Health and Medical Research Fellowship awarded by the Victorian Government. O O Adetokunboh acknowledges the South African Department of Science and Innovation and the National Research Foundation. A Agrawal acknowledges the Wellcome Trust DBT India Alliance Senior Fellowship. S M Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. M Ausloos, C Herteliu, and A Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. A Badawi is supported by the Public Health Agency of Canada. D A Bennett was supported by the NIHR Oxford Biomedical Research Centre. R Bourne acknowledges the Brien Holden Vision Institute, University of Heidelberg, Sightsavers, Fred Hollows Foundation, and Thea Foundation. G B Britton and I Moreno Velasquez were supported by the Sistema Nacional de Investigacion, SNI-SENACYT, Panama. R Buchbinder was supported by an Australian National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship. J J Carrero was supported by the Swedish Research Council (2019-01059). F Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. A R Chang was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases grant K23 DK106515. V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundacao para a Ciencia e Tecnologia, IP, under the Norma Transitaria DL57/2016/CP1334/CT0006. A Douiri acknowledges support and funding from the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust and the Royal College of Physicians, and support from the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. B B Duncan acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. H E Erskine is the recipient of an Australian NHMRC Early Career Fellowship grant (APP1137969). A J Ferrari was supported by a NHMRC Early Career Fellowship grant (APP1121516). H E Erskine and A J Ferrari are employed by and A M Mantilla-Herrera and D F Santomauro affiliated with the Queensland Centre for Mental Health Research, which receives core funding from the Queensland Department of Health. M L Ferreira holds an NHMRC Research Fellowship. C Flohr was supported by the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust. M Freitas acknowledges financial support from the EU (European Regional Development Fund [FEDER] funds through COMPETE POCI-01-0145-FEDER-029248) and National Funds (Fundacao para a Ciencia e Tecnologia) through project PTDC/NAN-MAT/29248/2017. A L S Guimaraes acknowledges support from CNPq. C Herteliu was partially supported by a grant co-funded by FEDER through Operational Competitiveness Program (project ID P_40_382). P Hoogar acknowledges Centre for Bio Cultural Studies, Directorate of Research, Manipal Academy of Higher Education and Centre for Holistic Development and Research, Kalaghatagi. F N Hugo acknowledges the Visiting Professorship, PRINT Program, CAPES Foundation, Brazil. B-F Hwang was supported by China Medical University (CMU107-Z-04), Taichung, Taiwan. S M S Islam was funded by a National Heart Foundation Senior Research Fellowship and supported by Deakin University. R Q Ivers was supported by a research fellowship from the National Health and Medical Research Council of Australia. M Jakovljevic acknowledges the Serbian part of this GBD-related contribution was co-funded through Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. P Jeemon was supported by a Clinical and Public Health intermediate fellowship (grant number IA/CPHI/14/1/501497) from the Wellcome Trust-Department of Biotechnology, India Alliance (2015-20). O John is a recipient of UIPA scholarship from University of New South Wales, Sydney. S V Katikireddi acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_12017/13, MC_UU_12017/15), and the Scottish Government Chief Scientist Office (SPHSU13, SPHSU15). C Kieling is a CNPq researcher and a UK Academy of Medical Sciences Newton Advanced Fellow. Y J Kim was supported by Research Management Office, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/00010). K Krishan is supported by UGC Centre of Advanced Study awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M Kumar was supported by K43 TW 010716 FIC/NIMH. B Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. J V Lazarus was supported by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III [ISCIII]/ESF, the EU [CP18/00074]). K J Looker thanks the NIHR Health Protection Research Unit in Evaluation of Interventions at the University of Bristol, in partnership with Public Health England, for research support. S Lorkowski was funded by the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1808A). R A Lyons is supported by Health Data Research UK (HDR-9006), which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, NIHR (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and Wellcome Trust. J J McGrath is supported by the Danish National Research Foundation (Niels Bohr Professorship), and the Queensland Health Department (via West Moreton HHS). P T N Memiah acknowledges support from CODESRIA. U O Mueller gratefully acknowledges funding by the German National Cohort Study BMBF grant number 01ER1801D. S Nomura acknowledges the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). A Ortiz was supported by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. S B Patten was supported by the Cuthbertson & Fischer Chair in Pediatric Mental Health at the University of Calgary. G C Patton was supported by an aNHMRC Senior Principal Research Fellowship. M R Phillips was supported in part by the National Natural Science Foundation of China (NSFC, number 81371502 and 81761128031). A Raggi, D Sattin, and S Schiavolin were supported by grants from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4-Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). P Rathi and B Unnikrishnan acknowledge Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal. A L P Ribeiro was supported by Brazilian National Research Council, CNPq, and the Minas Gerais State Research Agency, FAPEMIG. D C Ribeiro was supported by The Sir Charles Hercus Health Research Fellowship (#18/111) Health Research Council of New Zealand. D Ribeiro acknowledges financial support from the EU (FEDER funds through the Operational Competitiveness Program; POCI-01-0145-FEDER-029253). P S Sachdev acknowledges funding from the NHMRC of Australia Program Grant. A M Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. M M Santric-Milicevic acknowledges the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract number 175087). R Sarmiento-Suarez received institutional support from Applied and Environmental Sciences University (Bogota, Colombia) and ISCIII (Madrid, Spain). A E Schutte received support from the South African National Research Foundation SARChI Initiative (GUN 86895) and Medical Research Council. S T S Skou is currently funded by a grant from Region Zealand (Exercise First) and a grant from the European Research Council under the EU's Horizon 2020 research and innovation program (grant agreement number 801790). J B Soriano is funded by Centro de Investigacion en Red de Enfermedades Respiratorias, ISCIII. R Tabares-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII-FEDER. N Taveira was partially supported by the European & Developing Countries Clinical Trials Partnership, the EU (LIFE project, reference RIA2016MC-1615). S Tyrovolas was supported by the Foundation for Education and European Culture, the Sara Borrell postdoctoral programme (reference number CD15/00019 from ISCIII-FEDER). S B Zaman received a scholarship from the Australian Government research training programme in support of his academic career., "Peer Reviewed"

Published
2020

37. Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017

Author

Hassan Haghparast Bidgoli, Young Eun Kim, Duduzile Ndwandwe, Marilita M Moschos, Diego De Leo, Mark A. Stokes, Faris Lami, Lorenzo Monasta, Amit Arora, Hamid Asayesh, Dhirendra N Sinha, Ferrán Catalá-López, Ana Maria Nogales Vasconcelos, Swayam Prakash, Rafael Tabarés-Seisdedos, Melkamu Merid Mengesha, Yuichiro Yano, Olalekan A. Uthman, Amir Radfar, Manasi Kumar, Kamarul Imran Musa, Babak Moazen, Spencer L. James, Ahmad Daryani, Achala Upendra Jayatilleke, Siavash Rahimi, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Meysam Behzadifar, Dan J. Stein, Kathryn H. Jacobsen, Jiabin Shen, Rajesh Kumar Rai, Ehimario U. Igumbor, Amir Kasaeian, Ali Kabir, Morteza Shamsizadeh, Ziad El-Khatib, Sharareh Eskandarieh, Sorin Hostiuc, Jarnail Singh Thakur, Takeshi Fukumoto, Shai Linn, João Pedro Silva, Olayinka Stephen Ilesanmi, Gizachew Assefa Tessema, Naohiro Yonemoto, Jacek Jerzy Jozwiak, Masood Ali Shaikh, Seyyed Meysam Mousavi, Syed Mohamed Aljunid, Azeem Majeed, Alexandra Brazinova, Nader Jahanmehr, Yuming Guo, Sonia Saxena, Juanita A. Haagsma, Devasahayam J. Christopher, Lorainne Tudor Car, Shamsa Zafar, Roghayeh Mohammadibakhsh, Khanh Bao Tran, Reza Malekzadeh, Martha Híjar, Addisu Melese, Tinuke O Olagunju, Guoqing Hu, Yousef Khader, Olatunde Aremu, Yahya Salimi, Corina Benjet, Seyed-Mohammad Fereshtehnejad, Julio Cesar Campuzano Rincon, Rizwan Kalani, Bach Xuan Tran, Serge Resnikoff, Félix Carvalho, Suzanne Barker-Collo, Basema Saddik, Abraham Getachew Kelbore, Chris D Castle, Andre Pascal Kengne, Joan B. Soriano, Aliasghar Ahmad Kiadaliri, Derrick A Bennett, Pedro R. Olivares, Ali Bijani, Shanshan Li, Srinivas Murthy, Dragos Virgil Davitoiu, Farid Najafi, Seyed Sina Naghibi Irvani, Maziar Moradi-Lakeh, Adauto Martins Soares Filho, Vasily Vlassov, Alessandra C. Goulart, Alireza Ahmadi, Theo Vos, Heather Orpana, Narayan Bahadur Mahotra, Dillon O Sylte, Tuomo J. Meretoja, Ireneous N. Soyiri, Susan M Sawyer, Nauman Khalid, Louisa Degenhardt, Kebede Embaye Gezae, Ubai Alsharif, Richard C. Franklin, Shane D. Morrison, Randah R. Hamadeh, G. K. Mini, Naznin Hossain, Zachary V Dingels, Kate Dolan, Florian Fischer, Atte Meretoja, Yasir Waheed, Milena M Santric Milicevic, Ai Koyanagi, Sadaf G. Sepanlou, Manisha Dubey, Michael Phillips, Koustuv Dalal, Maysaa El Sayed Zaki, Elena Varavikova, Rahul Gupta, Rajaa Al-Raddadi, Sergey Soshnikov, David Laith Rawaf, Zoubida Zaidi, David C. Schwebel, Hassan Magdy Abd El Razek, Jost B. Jonas, Flávia Ribeiro Machado, Yoshan Moodley, Stefania Mondello, Nicholas L S Roberts, N. Bedi, Amrit Banstola, Yong Zhao, Vladimir I. Starodubov, Beatriz Paulina Ayala Quintanilla, Juan Jesus Carrero, Manzoor Ahmad Malik, George C Patton, André Faro, In-Hwan Oh, Anwar Rafay, Simon I. Hay, Deborah Carvalho Malta, Erin B Hamilton, Man Mohan Mehndiratta, Suliman Alghnam, Olanrewaju Oladimeji, Sojib Bin Zaman, Ratilal Lalloo, Zichen Liu, Mahmood Moosazadeh, Isabela M. Benseñor, Muluken Azage Yenesew, Ivy Shiue, Hilton Lam, Soraya Seedat, Mete Saylan, Eduarda Fernandes, Khalid A Altirkawi, Chuanhua Yu, Jasvinder A. Singh, Pascual R. Valdez, Jan-Walter De Neve, Guilherme Borges, Seth Christopher Yaw Appiah, Linh Phuong Doan, Christopher S. Crowe, Andualem Henok, Carlos A Castañeda-Orjuela, Mina Anjomshoa, Bruno Ramos Nascimento, Paul S. F. Yip, Samath D Dharmaratne, Ayman Grada, Christian Lycke Ellingsen, Zulfiqar A Bhutta, Gurudatta Naik, Shahrzad Bazargan-Hejazi, Tomislav Mestrovic, Long Hoang Nguyen, Karen M. Tabb, Kebede Deribe, Mustafa Z. Younis, Yuan-Pang Wang, Van C. Lansingh, Felix Akpojene Ogbo, Mihajlo Jakovljevic, Till Bärnighausen, Naser Mohammad Gholi Mezerji, Kiana Ramezanzadeh, Muhammed Magdy Abd El Razek, Rasmus Havmoeller, Konrad Pesudovs, Salman Rawaf, Walter Mendoza, Smita Pakhale, Mahesh P A, Ted R. Miller, Rebecca Ivers, Gabrielle deVeber, Pallab K. Maulik, Ali H. Mokdad, Burcu Kucuk Bicer, Andre M. N. Renzaho, Muhammad Aziz Rahman, Fares Alahdab, Vafa Rahimi-Movaghar, Dipan Bose, Alireza Rafiei, Payman Salamati, Engida Yisma, Huong Lan Thi Nguyen, Juan Sanabria, Priyanka Yadav, Andrew T Olagunju, Ejaz Ahmad Khan, Irina Filip, Shahab Rezaeian, Ghobad Moradi, Mohammad Zamani, Rosario Cárdenas, Delia Hendrie, Yogesh Sabde, Marek Majdan, Mariam Molokhia, Adnan Kisa, Jacob E. Sunshine, Narayanaswamy Venketasubramanian, Mahdi Sharif-Alhoseini, Sanjay Zodpey, Ashish Awasthi, Rahman Shiri, Zahra Jorjoran Shushtari, Shivanthi Balalla, Samer Hamidi, Hailemariam Abiy Alemu Meheretu, Raimundas Lunevicius, Suzanne Polinder, Tomasz Miazgowski, Sheikh Mohammed Shariful Islam, Tim Driscoll, Son Hoang Nguyen, Mika Shigematsu, Bryan L. Sykes, Arash Tehrani-Banihashemi, Dina Nur Anggraini Ningrum, Josep Maria Haro, Leonardo Roever, Gholamreza Roshandel, Andrea Sylvia Winkler, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Luca Ronfani, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Jee-Young Jasmine Choi, Mohammad Ali Mansournia, Daniel Kim, Maheswar Satpathy, Ionut Negoi, Michael K. Hole, Miloud Taki Eddine Aichour, Erkin M. Mirrakhimov, Barthelemy Kuate Defo, Alan D. Lopez, Masoud Behzadifar, Rohan Borschmann, Ana-Laura Manda, Ione Jayce Ceola Schneider, Lydia R. Lucchesi, Trang Huyen Nguyen, Mu'awiyyah Babale Sufiyan, Janet L Leasher, Shafiu Mohammed, Lidia Morawska, Getenet Dessie, Reza Assadi, Tiffany K. Gill, Francesco Saverio Violante, Monika Sawhney, Enayatollah Homaie Rad, Yirga Legesse Nirayo, Muktar Beshir Ahmed, Oladimeji Adebayo, Mikk Jürisson, Soumyadeep Bhaumik, Hadi Hassankhani, Stanislav S. Otstavnov, Aziz Sheikh, Benjamin Uzochukwu, Aman Yesuf Endries, Eun-Kee Park, Jack T Fox, Abdallah M. Samy, Richard Ofori-Asenso, Ravi Prakash Jha, Inbal Salz, Benjamin B. Massenburg, Soufiane Boufous, Hamid Yimam Hassen, Pablo Montero-Zamora, Tissa Wijeratne, Abdullah T Khoja, Lidia Sanchez Riera, Vinay Nangia, Bill & Melinda Gates Foundation, Haagsma, Juanita A, James, Spencer L, Castle, Chris D, Dingels, Zachary V, Yisma, Engida, Vos, Theo, Haagsma J.A., James S.L., Castle C.D., Dingels Z.V., Fox J.T., Hamilton E.B., Liu Z., Lucchesi L.R., Roberts N.L.S., Sylte D.O., Adebayo O.M., Ahmadi A., Ahmed M.B., Aichour M.T.E., Alahdab F., Alghnam S.A., Aljunid S.M., Al-Raddadi R.M., Alsharif U., Altirkawi K., Anjomshoa M., Antonio C.A.T., Appiah S.C.Y., Aremu O., Arora A., Asayesh H., Assadi R., Awasthi A., Ayala Quintanilla B.P., Balalla S., Banstola A., Barker-Collo S.L., Barnighausen T.W., Bazargan-Hejazi S., Bedi N., Behzadifar M., Benjet C., Bennett D.A., Bensenor I.M., Bhaumik S., Bhutta Z.A., Bijani A., Borges G., Borschmann R., Bose D., Boufous S., Brazinova A., Campuzano Rincon J.C., Cardenas R., Carrero J.J., Carvalho F., Castaneda-Orjuela C.A., Catala-Lopez F., Choi J.-Y.J., Christopher D.J., Crowe C.S., Dalal K., Daryani A., Davitoiu D.V., Degenhardt L., De Leo D., De Neve J.-W., Deribe K., Dessie G.A., Deveber G.A., Dharmaratne S.D., Doan L.P., Dolan K.A., Driscoll T.R., Dubey M., El-Khatib Z., Ellingsen C.L., El Sayed Zaki M., Endries A.Y., Eskandarieh S., Faro A., Fereshtehnejad S.-M., Fernandes E., Filip I., Fischer F., Franklin R.C., Fukumoto T., Gezae K.E., Gill T.K., Goulart A.C., Grada A., Guo Y., Gupta R., Haghparast Bidgoli H., Haj-Mirzaian A., Hamadeh R.R., Hamidi S., Haro J.M., Hassankhani H., Hassen H.Y., Havmoeller R., Hendrie D., Henok A., Hijar M., Hole M.K., Homaie Rad E., Hossain N., Hostiuc S., Hu G., Igumbor E.U., Ilesanmi O.S., Irvani S.S.N., Islam S.M.S., Ivers R.Q., Jacobsen K.H., Jahanmehr N., Jakovljevic M., Jayatilleke A.U., Jha R.P., Jonas J.B., Jorjoran Shushtari Z., Jozwiak J.J., Jurisson M., Kabir A., Kalani R., Kasaeian A., Kelbore A.G., Kengne A.P., Khader Y.S., Khafaie M.A., Khalid N., Khan E.A., Khoja A.T., Kiadaliri A.A., Kim Y.-E., Kim D., Kisa A., Koyanagi A., Kuate Defo B., Kucuk Bicer B., Kumar M., Lalloo R., Lam H., Lami F.H., Lansingh V.C., Leasher J.L., Li S., Linn S., Lunevicius R., MacHado F.R., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahotra N.B., Majdan M., Majeed A., Malekzadeh R., Malik M.A., Malta D.C., Manda A.-L., Mansournia M.A., Massenburg B.B., Maulik P.K., Meheretu H.A.A., Mehndiratta M.M., Melese A., Mendoza W., Mengesha M.M., Meretoja T.J., Meretoja A., Mestrovic T., Miazgowski T., Miller T.R., Mini G.K., Mirrakhimov E.M., Moazen B., Mohammad Gholi Mezerji N., Mohammadibakhsh R., Mohammed S., Molokhia M., Monasta L., Mondello S., Montero-Zamora P.A., Moodley Y., Moosazadeh M., Moradi G., Moradi-Lakeh M., Morawska L., Velasquez I.M., Morrison S.D., Moschos M.M., Mousavi S.M., Murthy S., Musa K.I., Naik G., Najafi F., Nangia V., Nascimento B.R., Ndwandwe D.E., Negoi I., Nguyen T.H., Nguyen S.H., Nguyen L.H., Nguyen H.L.T., Ningrum D.N.A., Nirayo Y.L., Ofori-Asenso R., Ogbo F.A., Oh I.-H., Oladimeji O., Olagunju A.T., Olagunju T.O., Olivares P.R., Orpana H.M., Otstavnov S.S., Mahesh P.A., Pakhale S., Park E.-K., Patton G.C., Pesudovs K., Phillips M.R., Polinder S., Prakash S., Radfar A., Rafay A., Rafiei A., Rahimi S., Rahimi-Movaghar V., Rahman M.A., Rai R.K., Ramezanzadeh K., Rawaf S., Rawaf D.L., Renzaho A.M.N., Resnikoff S., Rezaeian S., Roever L., Ronfani L., Roshandel G., Sabde Y.D., Saddik B., Salamati P., Salimi Y., Salz I., Samy A.M., Sanabria J., Sanchez Riera L., Santric Milicevic M.M., Satpathy M., Sawhney M., Sawyer S.M., Saxena S., Saylan M., Schneider I.J.C., Schwebel D.C., Seedat S., Sepanlou S.G., Shaikh M.A., Shams-Beyranvand M., Shamsizadeh M., Sharif-Alhoseini M., Sheikh A., Shen J., Shigematsu M., Shiri R., Shiue I., Silva J.P., Singh J.A., Sinha D.N., Soares Filho A.M., Soriano J.B., Soshnikov S., Soyiri I.N., Starodubov V.I., Stein D.J., Stokes M.A., Sufiyan M.B., Sunshine J.E., Sykes B.L., Tabares-Seisdedos R., Tabb K.M., Tehrani-Banihashemi A., Tessema G.A., Thakur J.S., Tran K.B., Tran B.X., Tudor Car L., Uthman O.A., Uzochukwu B.S.C., Valdez P.R., Varavikova E., Vasconcelos A.M.N., Venketasubramanian N., Violante F.S., Vlassov V., Waheed Y., Wang Y.-P., Wijeratne T., Winkler A.S., Yadav P., Yano Y., Yenesew M.A., Yip P., Yisma E., Yonemoto N., Younis M.Z., Yu C., Zafar S., Zaidi Z., Zaman S.B., Zamani M., Zhao Y., Zodpey S., Hay S.I., Lopez A.D., Mokdad A.H., Vos T., Public Health, HUS Comprehensive Cancer Center, Clinicum, Department of Surgery, University of Helsinki, Helsinki University Hospital Area, and HUS Neurocenter

Subjects
Epidemiology, burden of disease, descriptive epidemiology, epidemiology, ECONOMIC-DEVELOPMENT, 1106 Human Movement and Sports Sciences, Poison control, Global Health, Global Burden of Disease, 0302 clinical medicine, Quality-Adjusted Life Year, Global health, 030212 general & internal medicine, 10. No inequality, 1. No poverty, Burden of disease, DALYS, 3142 Public health care science, environmental and occupational health, ddc, 3. Good health, Descriptive epidemiology, Epidemiological transition, REGISTRATION, Disabled Person, Public Health, Human, medicine.medical_specialty, DEATHS, Adolescent, 1117 Public Health and Health Services, 03 medical and health sciences, Life Expectancy, Injury prevention, SYSTEMATIC ANALYSIS, medicine, Disability-adjusted life year, Disease burden, Estimation, burden of disease, descriptive epidemiology, epidemiology, MORTALITY, Public health, EPIDEMIOLOGIC TRANSITION, Public Health, Environmental and Occupational Health, 030208 emergency & critical care medicine, TRENDS, EXPECTANCY HALE, 1701 Psychology, Wounds and Injuries, Human medicine, Demography
Abstract

Incluye: Correction: Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Inj Prev. 2020 Oct;26(Supp 1):i164. doi: 10.1136/injuryprev-2019-043296corr1. Epub 2020 Sep 28. PMID: 32989004 Background: The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods: Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. Results: For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions: The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum. Funding for GBD 2017 was provided by the Bill and Melinda Gates Foundation. Sí

Published
2020

38. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Author

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Subjects
Male, Health Status, health statu, HALE, mortality rate, communicable disease, DALYs, Global Burden of Disease, Risk Factors, Prevalence, Medicine and Health Sciences, Singapore, OUTCOMES, disability-adjusted life year, international cooperation, Medicine (all), 11 Medical And Health Sciences, Central African Republic, newborn disease, IRON-DEFICIENCY, AIDS, priority journal, Bahrain, disease severity, Female, Quality-Adjusted Life Years, cerebrovascular accident, Ukraine, Life Sciences & Biomedicine, INTERVENTIONS, Slovakia, DISORDERS, Burundi, WEIGHTS, GBD 2017 DALYs and HALE Collaborators, Communicable Diseases, Article, STYLE, Medicine, General & Internal, Life Expectancy, General & Internal Medicine, Humans, Disabled Persons, human, Healthy Lifestyle, HALE, DALYs, global burden of disease, Mortality, Aged, Science & Technology, Mortality, Premature, HIV, ischemic heart disease, major clinical study, PREVENTION, non communicable disease, GBD, disability-adjusted life-years, age, sex factor, Socioeconomic Factors, Algeria, Federation of Bosnia and Herzegovina, lower respiratory tract infection, Wounds and Injuries, GENDER, Human medicine, trend study, chronic obstructive lung disease
Abstract

Background How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-specific mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7.4 years (95% uncertainty interval 74-7.8), from 65.6 years (65.3-65- 8) in 1990 to 73.0 years (72.7-73.3) in 2017. The increase in years of life varied from 5.1 years (5.0-5.3) in high SDI countries to 12.0 years (11.3-12.8) in low SDI countries. Of the additional years of life expected at birth, 26.3% (20.1-33.1) were expected to be spent in poor health in high SDI countries compared with 11.7% (8.8-15.1) in low-middle SDI countries. HALE at birth increased by 6.3 years (5.9-6.7), from 57.0 years (54.6-59.1) in 1990 to 63.3 years (60.5-65.7) in 2017. The increase varied from 3.8 years (3.4-4.1) in high SDI countries to 10.5 years (9.8-11.2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1.0 year (0.4-1.7) in Saint Vincent and the Grenadines (62.4 years [59.9-64.7] in 1990 to 63.5 years [60.9-65.8] in 2017) to 23.7 years (21.9-25.6) in Eritrea (30.7 years [28.9-32.2] in 1990 to 54.4 years [51.5-57.1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1.4 years (0.6-2.3) in Algeria to 11.9 years (10.9-12.9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75.8 years [72.4-78.7]) and males (72.6 years [69 " 8-75.0]) and the lowest estimates were in Central African Republic (47.0 years [43.7-50.2] for females and 42.8 years [40.1-45.6] for males). Globally, in 2017, the five leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41.3% (38.8-43.5) for communicable diseases and by 49"8% (47.9-51.6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40.1% (36.8-43.0), although age-standardised DALY rates decreased by 18.1% (16.0-20.2). Interpretation With increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low S DI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.

Published
2018

39. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Author

Vos, T, Barber, Rm, Bell, B, Bertozzi Villa, A, Biryukov, S, Bolliger, I, Charlson, F, Davis, A, Degenhardt, L, Dicker, D, Duan, L, Erskine, H, Feigin, Vl, Ferrari, Aj, Fitzmaurice, C, Fleming, T, Graetz, N, Guinovart, C, Haagsma, J, Hansen, Gm, Hanson, Sw, Heuton, Kr, Higashi, H, Kassebaum, N, Kyu, H, Laurie, E, Liang, X, Lofgren, K, Lozano, R, Macintyre, Mf, Moradi Lakeh, M, Naghavi, M, Nguyen, G, Odell, S, Ortblad, K, Roberts, Da, Roth, Ga, Sandar, L, Serina, Pt, Stanaway, Jd, Steiner, C, Thomas, B, Vollset, Se, Whiteford, H, Wolock, Tm, Ye, P, Zhou, M, Ãvila, Ma, Aasvang, Gm, Abbafati, C, Abbasoglu, Ozgoren, A, Abd Allah, F, Abdel, Aziz, Abera, Sf, Aboyans, V, Abraham, Jp, Abraham, B, Abubakar, I, Abu Raddad, Lj, Abu Rmeileh, Nm, Aburto, Tc, Achoki, T, Ackerman, In, Adelekan, A, Ademi, Z, Adou, Ak, Adsuar, Jc, Arnlov, J, Agardh, Ee, Khabouri, Al, Alam, Ss, Alasfoor, D, Albittar, Mi, Alegretti, Ma, Aleman, Av, Alemu, Za, Alfonso Cristancho, R, Alhabib, S, Ali, R, Alla, F, Allebeck, 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Gabbe, Bj, Gankpe, Fg, Garcia, Guerra, Geleijnse, Fa, Gessner, Bd, Gibney, Kb, Gillum, Rf, Ginawi, Ia, Giroud, M, Giussani, G, Goenka, S, Goginashvili, K, Gona, P, Gonzalez, De, Cosio, T, Gosselin, Ra, Gotay, Cc, Goto, A, Gouda, Hn, Guerrant, Rl, Gugnani, Hc, Gunnell, D, Gupta, R, Gutierrez, Ra, Hafezi Nejad, N, Hagan, H, Halasa, Y, Hamadeh, Rr, Hamavid, H, Hammami, M, Hankey, Gj, Hao, Y, Harb, Hl, Haro, Jm, Havmoeller, R, Hay, Rj, Hay, S, Hedayati, Mt, Heredia, Pi, Heydarpour, P, Hijar, M, Hoek, Hw, Hoffman, Hj, Hornberger, Jc, Hosgood, Hd, Hossain, M, Hotez, Pj, Hoy, Dg, Hsairi, M, Hu, H, Hu, G, Huang, Jj, Huang, C, Huiart, L, Husseini, A, Iannarone, M, Iburg, Km, Innos, K, Inoue, M, Jacobsen, Kh, Jassal, Sk, Jeemon, P, Jensen, Pn, Jha, V, Jiang, G, Jiang, Y, Jonas, Jb, Joseph, J, Juel, K, Kan, H, Karch, A, Karimkhani, C, Karthikeyan, G, Katz, R, Kaul, A, Kawakami, N, Kazi, Ds, Kemp, Ah, Kengne, Ap, Khader, Ys, Khalifa, Se, Khan, Ea, Khan, G, Khang, Yh, Khonelidze, I, Kieling, C, 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Singh, L, Skirbekk, V, Sliwa, K, Soljak, M, Soneji, S, Soshnikov, Ss, Speyer, P, Sposato, La, Sreeramareddy, Ct, Stoeckl, H, Stathopoulou, Vk, Steckling, N, Stein, Mb, Stein, Dj, Steiner, Tj, Stewart, A, Stork, E, Stovner, Lj, Stroumpoulis, K, Sturua, L, Sunguya, Bf, Swaroop, M, Sykes, Bl, Tabb, Km, Takahashi, K, Tan, F, Tandon, N, Tanne, D, Tanner, M, Tavakkoli, M, Taylor, Hr, Ao, Te, Temesgen, Am, Ten, Have, M, Tenkorang, Ey, Terkawi, As, Theadom, Am, Thomas, E, Thorne Lyman, Al, Thrift, Ag, Tleyjeh, Im, Tonelli, M, Topouzis, F, Towbin, Ja, Toyoshima, H, Traebert, J, Tran, Bx, Trasande, L, Trillini, M, Truelsen, T, Trujillo, U, Tsilimbaris, M, Tuzcu, Em, Ukwaja, Kn, Undurraga, Ea, Uzun, Sb, Van, Brakel, Van, Wh, Vijver, De, Van, S, Dingenen, R, Van, Gool, Varakin, Yy, Vasankari, Tj, Vavilala, Ms, Veerman, Lj, Velasquez, Melendez, G, Venketasubramanian, N, Vijayakumar, L, Villalpando, S, Violante, Fs, Vlassov, Vv, Waller, S, Wallin, Mt, Wan, X, Wang, L, Wang, J, Wang, Y, Warouw, Ts, Weichenthal, S, Weiderpass, E, Weintraub, Rg, Werdecker, A, Wessells, Kr, Westerman, R, Wilkinson, Jd, Williams, Hc, Williams, Tn, Woldeyohannes, Sm, Wolfe, Cd, Wong, Jq, Wong, H, Woolf, Ad, Wright, Jl, Wurtz, B, Xu, G, Yang, G, Yano, Y, Yenesew, Ma, Yentur, Gk, Yip, P, Yonemoto, N, Yoon, Sj, Younis, M, Yu, C, Kim, Ky, Zaki, Mel, Zhang, Y, Zhao, Z, Zhao, Y, Zhu, J, Zonies, D, Zunt, Jr, Salomon, Ja, Murray, C. J., Vos, T, Barber, Rm, Bell, B, Bertozzi-Villa, A, Biryukov, S, Bolliger, I, Charlson, F, Davis, A, Degenhardt, L, Dicker, D, Duan, L, Erskine, H, Feigin, Vl, Ferrari, Aj, Fitzmaurice, C, Fleming, T, Graetz, N, Guinovart, C, Haagsma, J, Hansen, Gm, Hanson, Sw, Heuton, Kr, Higashi, H, Kassebaum, N, Kyu, H, Laurie ELiang, X, Lofgren, K, Lozano, R, Macintyre, Mf, Moradi-Lakeh, M, Naghavi, M, Nguyen, G, Odell, S, Ortblad, K, Roberts, Da, Roth, Ga, Sandar, L, Serina, Pt, Stanaway, Jd, Steiner, C, Thomas, B, Vollset, Se, Whiteford, H, Wolock, Tm, Ye, P, Zhou, M, Ãvila, Ma, Aasvang, Gm, Abbafati, C, Abbasoglu Ozgoren, A, Abd-Allah, F, Abdel Aziz MI, Abera, Sf, Aboyans, V, Abraham, Jp, Abraham, B, Abubakar, I, Abu-Raddad, Lj, Abu-Rmeileh, Nm, Aburto, Tc, Achoki TAckerman IN, Adelekan, A, Ademi, Z, Adou, Ak, Adsuar, Jc, Arnlov, J, Agardh, Ee, Al Khabouri MJ, Alam, S, Alasfoor, D, Albittar, Mi, Alegretti MAAleman AV, Alemu, Za, Alfonso-Cristancho, R, Alhabib, S, Ali, R, Alla, F, Allebeck, P, Allen, Pj, Almazroa, Ma, Alsharif, U, Alvarez, E, Alvis-Guzman NAmeli, O, Amini, H, Ammar, W, Anderson, Bo, Anderson, Hr, Antonio, Ca, Anwari, P, Apfel, H, Arsenijevic, V, Artaman, A, Asghar, Rj, Assadi, R, Atkins, L, Atkinson, C, Badawi, A, Bahit, Mc, Bakfalouni, T, Balakrishnan, K, Balalla, S, Banerjee, A, Barker-Collo, Sl, Barquera, S, Barregard, L, Barrero LHBasu, S, Basu, A, Baxter, A, Beardsley, J, Bedi, N, Beghi, E, Bekele, T, Bell, Ml, Benjet, C, Bennett, Da, Bensenor, Im, Benzian, H, Bernabe, E, Beyene TJBhala, N, Bhalla, A, Bhutta, Z, Bienhoff, K, Bikbov, B, Bin Abdulhak, A, Blore, Jd, Blyth, Fm, Bohensky, Ma, Bora Basara, B, Borges, G, Bornstein, Nm, Bose, D, Boufous, S, Bourne, Rr, Boyers, Ln, Brainin, M, Brauer, M, Brayne, Ce, Brazinova, A, Breitborde, Nj, Brenner, H, Briggs, Ad, Brooks, Pm, Brown JBrugha TS, Buchbinder, R, Buckle, Gc, Bukhman, G, Bulloch, Ag, Burch, M, Burnett, R, Cardenas, R, Cabral, Nl, Campos Nonato IR, Campuzano JCCarapetis JR, Carpenter, Do, Caso, V, Castaneda-Orjuela, Ca, Catala-Lopez, F, Chadha, Vk, Chang, Jc, Chen, H, Chen, W, Chiang, Pp, Chimed-Ochir, O, Chowdhury, R, Christensen, H, Christophi, Ca, Chugh, S, Cirillo, M, Coggeshall, M, Cohen, A, Colistro, V, Colquhoun, Sm, Contreras, Ag, Cooper LTCooper, C, Cooperrider, K, Coresh, J, Cortinovis, M, Criqui, Mh, Crump, Ja, Cuevas-Nasu, L, Dandona, R, Dandona, L, Dansereau, E, Dantes, Hg, Dargan, Pi, Davey, G, Davitoiu, Dv, Dayama, A, De la Cruz-Gongora, V, de la Vega SF, De Leo, D, del Pozo-Cruz, B, Dellavalle, Rp, Deribe, K, Derrett, S, Des Jarlais DC, Dessalegn, M, Deveber, Ga, Dharmaratne, Sd, Diaz-Torne, C, Ding, El, Dokova, K, Dorsey, Er, Driscoll, Tr, Duber, H, Durrani, Am, Edmond, Km, Ellenbogen, Rg, Endres, M, Ermakov, Sp, Eshrati, B, Esteghamati, A, Estep, K, Fahimi, S, Farzadfar, F, Fay, Df, Felson, Dt, Fereshtehnejad SMFernandes JG, Ferri, Cp, Flaxman, A, Foigt, N, Foreman, Kj, Fowkes, Fg, Franklin, Rc, Furst, T, Futran, Nd, Gabbe, Bj, Gankpe, Fg, Garcia-Guerra FAGeleijnse JM, Gessner, Bd, Gibney, Kb, Gillum, Rf, Ginawi, Ia, Giroud, M, Giussani, G, Goenka, S, Goginashvili, K, Gona, P, Gonzalez de Cosio TGosselin RA, Gotay, Cc, Goto, A, Gouda, Hn, Guerrant, Rl, Gugnani, Hc, Gunnell, D, Gupta, R, Gutierrez, Ra, Hafezi-Nejad, N, Hagan HHalasa, Y, Hamadeh, Rr, Hamavid, H, Hammami, M, Hankey, Gj, Hao, Y, Harb, Hl, Haro, Jm, Havmoeller, R, Hay, Rj, Hay, S, Hedayati, Mt, Heredia Pi IB, Heydarpour, P, Hijar, M, Hoek, Hw, Hoffman, Hj, Hornberger, Jc, Hosgood, Hd, Hossain, M, Hotez, Pj, Hoy, Dg, Hsairi, M, Hu, H, Hu, G, Huang JJHuang, C, Huiart, L, Husseini, A, Iannarone, M, Iburg, Km, Innos, K, Inoue, M, Jacobsen, Kh, Jassal, Sk, Jeemon, P, Jensen, Pn, Jha, V, Jiang, G, Jiang YJonas JB, Joseph, J, Juel, K, Kan, H, Karch, A, Karimkhani, C, Karthikeyan, G, Katz, R, Kaul, A, Kawakami, N, Kazi, D, Kemp, Ah, Kengne, Ap, Khader, Y, Khalifa, Se, Khan, Ea, Khan, G, Khang, Yh, Khonelidze, I, Kieling, C, Kim, D, Kim, S, Kimokoti, Rw, Kinfu, Y, Kinge, Jm, Kissela, Bm, Kivipelto MKnibbs, L, Knudsen, Ak, Kokubo, Y, Kosen, S, Kramer, A, Kravchenko, M, Krishnamurthi, Rv, Krishnaswami, S, Kuate Defo, B, Kucuk Bicer, B, Kuipers EJKulkarni VS, Kumar, K, Kumar, Ga, Kwan, Gf, Lai, T, Lalloo, R, Lam, H, Lan, Q, Lansingh, Vc, Larson, H, Larsson, A, Lawrynowicz, Ae, Leasher, Jl, Lee, Jt, Leigh, J, Leung, R, Levi, M, Li, B, Li, Y, Liang, J, Lim, S, Lin, Hh, Lind, M, Lindsay, Mp, Lipshultz, Se, Liu, S, Lloyd, Bk, Lockett Ohno, S, Logroscino, G, Looker, Kj, Lopez, Ad, Lopez-Olmedo, N, Lortet-Tieulent, J, Lotufo, Pa, Low, N, Lucas, Rm, Lunevicius, R, Lyons, Ra, Ma, J, Ma, S, Mackay MTMajdan, M, Malekzadeh, R, Mapoma, Cc, Marcenes, W, March, Lm, Margono, C, Marks, Gb, Marzan, Mb, Masci, Jr, Mason-Jones, Aj, Matzopoulos RGMayosi BM, Mazorodze, Tt, Mcgill, Nw, Mcgrath, Jj, Mckee, M, Mclain, A, Mcmahon, Bj, Meaney, Pa, Mehndiratta, Mm, Mejia-Rodriguez, F, Mekonnen, W, Melaku, Ya, Meltzer, M, Memish, Za, Mensah, G, Meretoja, A, Mhimbira, Fa, Micha, R, Miller, Tr, Mills, Ej, Mitchell, Pb, Mock, Cn, Moffitt TEMohamed Ibrahim, N, Mohammad, Ka, Mokdad, Ah, Mola, Gl, Monasta, L, Montico, M, Montine, Tj, Moore, Ar, Moran, Ae, Morawska, L, Mori RMoschandreas, J, Moturi, Wn, Moyer, M, Mozaffarian, D, Mueller, Uo, Mukaigawara, M, Murdoch, Me, Murray, J, Murthy, K, Naghavi, P, Nahas ZNaheed, A, Naidoo, K, Naldi, L, Nand, D, Nangia, V, Narayan, Km, Nash, D, Nejjari, C, Neupane, Sp, Newman, Lm, Newton, Cr, Ng, M, Ngalesoni FNNhung NT, Nisar, Mi, Nolte, S, Norheim, Of, Norman, Re, Norrving, B, Nyakarahuka, L, Oh, Ih, Ohkubo, T, Omer, Sb, Opio, Jn, Ortiz, A, Pandian JDPanelo CI, Papachristou, C, Park, Ek, Parry, Cd, Caicedo, Aj, Patten, Sb, Paul, Vk, Pavlin, Bi, Pearce, N, Pedraza, L, Pellegrini, Ca, Pereira, Dm, Perez-Ruiz, Fp, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, Cb, Petzold, M, Phillips, Mr, Phillips, D, Phillips, B, Piel, Fb, Plass, D, Poenaru, D, Polanczyk GVPolinder, S, Pope, Ca, Popova, S, Poulton, Rg, Pourmalek, F, Prabhakaran, D, Prasad, Nm, Qato, D, Quistberg, Da, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, Su, Raju, M, Rakovac, I, Rana, Sm, Razavi, H, Refaat, A, Rehm, J, Remuzzi, G, Resnikoff, S, Ribeiro, Al, Riccio, Pm, Richardson, L, Richardus, Jh, Riederer, Am, Robinson, M, Roca, A, Rodriguez, A, Rojas-Rueda, D, Ronfani, L, Rothenbacher, D, Roy, N, Ruhago, Gm, Sabin, N, Sacco, Rl, Ksoreide, K, Saha, S, Sahathevan, R, Sahraian, Ma, Sampson, U, Sanabria, Jr, Sanchez-Riera, L, Santos, I, Satpathy, M, Saunders, Je, Sawhney, M, Saylan MIScarborough, P, Schoettker, B, Schneider, Ij, Schwebel, Dc, Scott, Jg, Seedat, S, Sepanlou, Sg, Serdar, B, Servan-Mori, Ee, Shackelford, K, Shaheen AShahraz, S, Shamah Levy, T, Shangguan, S, She, J, Sheikhbahaei, S, Shepard, D, Shi, P, Shibuya, K, Shinohara, Y, Shiri, R, Shishani, K, Shiue, I, Shrime, Mg, Sigfusdottir, Id, Silberberg, Dh, Simard, Ep, Sindi, S, Singh, Ja, Singh, L, Skirbekk, V, Sliwa, K, Soljak, M, Soneji, S, Soshnikov, S, Speyer PSposato LA, Sreeramareddy, Ct, Stoeckl, H, Stathopoulou, Vk, Steckling, N, Stein, Mb, Stein, Dj, Steiner, Tj, Stewart, A, Stork, E, Stovner LJStroumpoulis, K, Sturua, L, Sunguya, Bf, Swaroop, M, Sykes, Bl, Tabb, Km, Takahashi, K, Tan, F, Tandon, N, Tanne, D, Tanner, M, Tavakkoli, M, Taylor, Hr, Te Ao BJ, Temesgen, Am, Ten Have, M, Tenkorang, Ey, Terkawi, A, Theadom, Am, Thomas, E, Thorne-Lyman, Al, Thrift, Ag, Tleyjeh, Im, Tonelli, M, Topouzis, F, Towbin, Ja, Toyoshima, H, Traebert, J, Tran, Bx, Trasande, L, Trillini, M, Truelsen, T, Trujillo, U, Tsilimbaris, M, Tuzcu, Em, Ukwaja KNUndurraga EA, Uzun, Sb, van Brakel WH, van de Vijver, S, Van Dingenen, R, van Gool CH, Varakin, Yy, Vasankari, Tj, Vavilala, M, Veerman LJVelasquez-Melendez, G, Venketasubramanian, N, Vijayakumar, L, Villalpando, S, Violante, F, Vlassov, Vv, Waller, S, Wallin, Mt, Wan, X, Wang, L, Wang, J, Wang, Y, Warouw, T, Weichenthal, S, Weiderpass, E, Weintraub, Rg, Werdecker, A, Wessells, Kr, Westerman, R, Wilkinson, Jd, Williams HCWilliams TN, Woldeyohannes, Sm, Wolfe, Cd, Wong, Jq, Wong, H, Woolf, Ad, Wright, Jl, Wurtz, B, Xu, G, Yang, G, Yano, Y, Yenesew, Ma, Yentur GKYip, P, Yonemoto, N, Yoon, Sj, Younis, M, Yu, C, Kim, Ky, Zaki Mel, S, Zhang, Y, Zhao, Z, Zhao, Y, Zhu, J, Zonies, D, Zunt, Jr, Salomon, Ja, Murray, Cj., Vos, Theo, Barber, Ryan M., Bell, Brad, Bertozzi-Villa, Amelia, Biryukov, Stan, Bolliger, Ian, Charlson, Fiona, Davis, Adrian, Degenhardt, Louisa, Dicker, Daniel, Duan, Leilei, Erskine, Holly, Feigin, Valery L., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Thoma, Graetz, Nichola, Guinovart, Caterina, Haagsma, Juanita, Hansen, Gillian M., Hanson, Sarah Wulf, Heuton, Kyle R., Higashi, Hideki, Kassebaum, Nichola, Kyu, Hmwe, Laurie, Evan, Liang, Xiofeng, Lofgren, Katherine, Lozano, Rafael, Macintyre, Michael F., Moradi-Lakeh, Maziar, Naghavi, Mohsen, Nguyen, Grant, Odell, Shaun, Ortblad, Katrina, Roberts, David Allen, Roth, Gregory A., Sandar, Logan, Serina, Peter T., Stanaway, Jeffrey D., Steiner, Caitlyn, Thomas, Bernadette, Vollset, Stein Emil, Whiteford, Harvey, Wolock, Timothy M., Ye, Pengpeng, Zhou, Maigeng, Ãvila, Marco A., Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Aziz, Muna I. Abdel, Abera, Semaw F., Aboyans, Victor, Abraham, Jerry P., Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M.E., Aburto, Tania C., Achoki, Tom, Ackerman, Ilana N., Adelekan, Ademola, Ademi, Zanfina, Adou, Arsène K., Adsuar, Josef C., Arnlov, Johan, Agardh, Emilie E., Al Khabouri, Mazin J., Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I., Alegretti, Miguel A., Aleman, Alicia V., Alemu, Zewdie A., Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Alla, Francoi, Allebeck, Peter, Allen, Peter J., Almazroa, Mohammad Abdulaziz, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O., Anderson, H. Ro, Antonio, Carl Abelardo T., Anwari, Palwasha, Apfel, Henry, Arsenijevic, Valentain S. Arsic, Artaman, Al, Asghar, Rana J., Assadi, Reza, Atkins, Lydia S., Atkinson, Charle, Badawi, Alaa, Bahit, Maria C., Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Banerjee, Amitava, Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lar, Barrero, Lope H., Basu, Sanjay, Basu, Arindam, Baxter, Amanda, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bekele, Tolesa, Bell, Michelle L., Benjet, Corina, Bennett, Derrick A., Bensenor, Isabela M., Benzian, Habib, Bernabe, Eduardo, Beyene, Tariku J., Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar, Bienhoff, Kelly, Bikbov, Bori, Abdulhak, Aref Bin, Blore, Jed D., Blyth, Fiona M., Bohensky, Megan A., Basara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M., Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R., Boyers, Lindsay N., Brainin, Michael, Brauer, Michael, Brayne, Carol E.G., Brazinova, Alexandra, Breitborde, Nicholas J.K., Brenner, Hermann, Briggs, Adam D.M., Brooks, Peter M., Brown, Jonathan, Brugha, Traolach S., Buchbinder, Rachelle, Buckle, Geoffrey C., Bukhman, Gene, Bulloch, Andrew G., Burch, Michael, Burnett, Richard, Cardenas, Rosario, Cabral, Norberto L., Campos-Nonato, Ismael R., Campuzano, Julio C., Carapetis, Jonathan R., Carpenter, David O., Caso, Valeria, Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Chadha, Vineet K., Chang, Jung-Chen, Chen, Honglei, Chen, Wanqing, Chiang, Peggy P., Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christensen, Hanne, Christophi, Costas A., Chugh, Sumeet S., Cirillo, Massimo, Coggeshall, Megan, Cohen, Aaron, Colistro, Valentina, Colquhoun, Samantha M., Contreras, Alejandra G., Cooper, Leslie T., Cooper, Cyru, Cooperrider, Kimberly, Coresh, Josef, Cortinovis, Monica, Criqui, Michael H., Crump, John A., Cuevas-Nasu, Lucia, Dandona, Rakhi, Dandona, Lalit, Dansereau, Emily, Dantes, Hector G., Dargan, Paul I., Davey, Gail, Davitoiu, Dragos V., Dayama, Anand, De La Cruz-Gongora, Vanessa, De La Vega, Shelley F., De Leo, Diego, Del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C., Dessalegn, Muluken, Deveber, Gabrielle A., Dharmaratne, Samath D., Diaz-Torne, Cesar, Ding, Eric L., Dokova, Klara, Dorsey, E.R., Driscoll, Tim R., Duber, Herbert, Durrani, Adnan M., Edmond, Karen M., Ellenbogen, Richard G., Endres, Matthia, Ermakov, Sergey P., Eshrati, Babak, Esteghamati, Alireza, Estep, Kara, Fahimi, Saman, Farzadfar, Farshad, Fay, Derek F.J., Felson, David T., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Ferri, Cluesa P., Flaxman, Abraham, Foigt, Nataliya, Foreman, Kyle J., Fowkes, F Gerry R., Franklin, Richard C., Furst, Thoma, Futran, Neal D., Gabbe, Belinda J., Gankpe, Fortune G., Garcia-Guerra, Francisco A., Geleijnse, Johanna M., Gessner, Bradford D., Gibney, Katherine B., Gillum, Richard F., Ginawi, Ibrahim A., Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Gona, Philimon, De Cosio, Teresita Gonzalez, Gosselin, Richard A., Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Guerrant, Richard L., Gugnani, Harish C., Gunnell, David, Gupta, Rajeev, Gupta, Rahul, Gutierrez, Reyna A., Hafezi-Nejad, Nima, Hagan, Holly, Halasa, Yara, Hamadeh, Randah R., Hamavid, Hannah, Hammami, Mouhanad, Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Haro, Josep Maria, Havmoeller, Rasmu, Hay, Roderick J., Hay, Simon, Hedayati, Mohammad T., Pi, Ileana B. Heredia, Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W., Hoffman, Howard J., Hornberger, John C., Hosgood, H. Dean, Hossain, Mazeda, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Hu, Howard, Hu, Guoqing, Huang, John J., Huang, Cheng, Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa, Iburg, Kim M., Innos, Kaire, Inoue, Manami, Jacobsen, Kathryn H., Jassal, Simerjot K., Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jonas, Jost B., Joseph, Jonathan, Juel, Knud, Kan, Haidong, Karch, Andre, Karimkhani, Chante, Karthikeyan, Ganesan, Katz, Ronit, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Kemp, Andrew H., Kengne, Andre P., Khader, Yousef S., Khalifa, Shams Eldin A.H., Khan, Ejaz A., Khan, Gulfaraz, Khang, Young-Ho, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kimokoti, Ruth W., Kinfu, Yohanne, Kinge, Jonas M., Kissela, Brett M., Kivipelto, Miia, Knibbs, Luke, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kosen, Soewarta, Kramer, Alexander, Kravchenko, Michael, Krishnamurthi, Rita V., Krishnaswami, Sanjay, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J., Kulkarni, Veena S., Kumar, Kaushalendra, Kumar, G Anil, Kwan, Gene F., Lai, Taavi, Lalloo, Ratilal, Lam, Hilton, Lan, Qing, Lansingh, Van C., Larson, Heidi, Larsson, Ander, Lawrynowicz, Alicia E.B., Leasher, Janet L., Lee, Jong-Tae, Leigh, Jame, Leung, Ricky, Levi, Miriam, Li, Bin, Li, Yichong, Li, Yongmei, Liang, Juan, Lim, Stephen, Lin, Hsien-Ho, Lind, Margaret, Lindsay, M Patrice, Lipshultz, Steven E., Liu, Shiwei, Lloyd, Belinda K., Ohno, Summer Lockett, Logroscino, Giancarlo, Looker, Katharine J., Lopez, Alan D., Lopez-Olmedo, Nancy, Lortet-Tieulent, Joannie, Lotufo, Paulo A., Low, Nicola, Lucas, Robyn M., Lunevicius, Raimunda, Lyons, Ronan A., Ma, Jixiang, Ma, Stefan, Mackay, Mark T., Majdan, Marek, Malekzadeh, Reza, Mapoma, Christopher C., Marcenes, Wagner, March, Lyn M., Margono, Chri, Marks, Guy B., Marzan, Melvin B., Masci, Joseph R., Mason-Jones, Amanda J., Matzopoulos, Richard G., Mayosi, Bongani M., Mazorodze, Tasara T., Mcgill, Neil W., Mcgrath, John J., Mckee, Martin, Mclain, Abby, Mcmahon, Brian J., Meaney, Peter A., Mehndiratta, Man Mohan, Mejia-Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A., Meltzer, Michele, Memish, Ziad A., Mensah, George, Meretoja, Atte, Mhimbira, Francis A., Micha, Renata, Miller, Ted R., Mills, Edward J., Mitchell, Philip B., Mock, Charles N., Moffitt, Terrie E., Ibrahim, Norlinah Mohamed, Mohammad, Karzan A., Mokdad, Ali H., Mola, Glen L., Monasta, Lorenzo, Montico, Marcella, Montine, Thomas J., Moore, Ami R., Moran, Andrew E., Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N., Moyer, Madeline, Mozaffarian, Dariush, Mueller, Ulrich O., Mukaigawara, Mitsuru, Murdoch, Michele E., Murray, Joseph, Murthy, Kinnari S., Naghavi, Paria, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S., Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K.M. Venkat, Nash, Deni, Nejjari, Chakib, Neupane, Sudan P., Newman, Lori M., Newton, Charles R., Ng, Marie, Ngalesoni, Frida N., Nhung, Nguyen T., Nisar, Muhammad I., Nolte, Sandra, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Oh, In Hwan, Ohkubo, Takayoshi, Omer, Saad B., Opio, John Nelson, Ortiz, Alberto, Pandian, Jeyaraj D., Panelo, Carlo Irwin A., Papachristou, Christina, Park, Eun-Kee, Parry, Charles D., Caicedo, Angel J. Paternina, Patten, Scott B., Paul, Vinod K., Pavlin, Boris I., Pearce, Neil, Pedraza, Lilia S., Pellegrini, Carlos A., Pereira, David M., Perez-Ruiz, Fernando P., Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B., Petzold, Max, Phillips, Michael R., Phillips, David, Phillips, Bryan, Piel, Frederic B., Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V., Polinder, Suzanne, Pope, C.A., Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M., Qato, Dima, Quistberg, D.A., Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M., Razavi, Homie, Refaat, Amany, Rehm, Jurgen, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Riccio, Patricia M., Richardson, Lee, Richardus, Jan Hendrik, Riederer, Anne M., Robinson, Margot, Roca, Anna, Rodriguez, Alina, Rojas-Rueda, David, Ronfani, Luca, Rothenbacher, Dietrich, Roy, Nobhojit, Ruhago, George M., Sabin, Nsanzimana, Sacco, Ralph L., Ksoreide, Kjetil, Saha, Sukanta, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Sampson, Uchechukwu, Sanabria, Juan R., Sanchez-Riera, Lidia, Santos, Itamar S., Satpathy, Maheswar, Saunders, James E., Sawhney, Monika, Saylan, Mete I., Scarborough, Peter, Schoettker, Ben, Schneider, Ione J.C., Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Serdar, Berrin, Servan-Mori, Edson E., Shackelford, Katya, Shaheen, Amira, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shepard, Donald S., Shi, Peilin, Shibuya, Kenji, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga D., Silberberg, Donald H., Simard, Edgar P., Sindi, Shireen, Singh, Jasvinder A., Singh, Lavanya, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Soshnikov, Sergey S., Speyer, Peter, Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stoeckl, Heidi, Stathopoulou, Vasiliki Kalliopi, Steckling, Nadine, Stein, Murray B., Stein, Dan J., Steiner, Timothy J., Stewart, Andrea, Stork, Eden, Stovner, Lars J., Stroumpoulis, Konstantino, Sturua, Lela, Sunguya, Bruno F., Swaroop, Mamta, Sykes, Bryan L., Tabb, Karen M., Takahashi, Ken, Tan, Feng, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Taylor, Hugh R., Te Ao, Braden J., Temesgen, Awoke Misganaw, Have, Margreet Ten, Tenkorang, Eric Yeboah, Terkawi, Abdullah Sulieman, Theadom, Alice M., Thomas, Elissa, Thorne-Lyman, Andrew L., Thrift, Amanda G., Tleyjeh, Imad M., Tonelli, Marcello, Topouzis, Foti, Towbin, Jeffrey A., Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X., Trasande, Leonardo, Trillini, Matia, Truelsen, Thoma, Trujillo, Ulise, Tsilimbaris, Miltiadi, Tuzcu, Emin M., Ukwaja, Kingsley N., Undurraga, Eduardo A., Uzun, Selen B., Van Brakel, Wim H., Van De Vijver, Steven, Dingenen, Rita Van, Van Gool, Coen H., Varakin, Yuri Y., Vasankari, Tommi J., Vavilala, Monica S., Veerman, Lennert J., Velasquez-Melendez, Gustavo, Venketasubramanian, Narayanaswamy, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S., Vlassov, Vasiliy V., Waller, Stephen, Wallin, Mitchell T., Wan, Xia, Wang, Linhong, Wang, Jianli, Wang, Yanping, Warouw, Tati S., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Wessells, K. Ryan, Westerman, Ronny, Wilkinson, James D., Williams, Hywel C., Williams, Thomas N., Woldeyohannes, Solomon M., Wolfe, Charles D.A., Wong, John Q., Wong, Haidong, Woolf, Anthony D., Wright, Jonathan L., Wurtz, Brittany, Xu, Gelin, Yang, Gonghuan, Yano, Yuichiro, Yenesew, Muluken A., Yentur, Gokalp K., Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa, Yu, Chuanhua, Kim, Kim Yun, Zaki, Maysaa El Sayed, Zhang, Yong, Zhao, Zheng, Zhao, Yong, Zhu, Jun, Zonies, David, Zunt, Joseph R., Salomon, Joshua A., Murray, Christopher J.L., Cell biology, Gastroenterology & Hepatology, Epidemiology, Health Technology Assessment (HTA), and Public Health

Subjects
Male, Gerontology, Nutrition and Disease, Epidemiology, years lived with disability, Global burden of disease, acute and chronic diseases, countries, Prevalence, Disease, Global Health, Medical and Health Sciences, Conduct disorder, Otitis-media, Cost of Illness, Residence Characteristics, Voeding en Ziekte, 80 and over, Global health, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, countries, Aetiology, Child, Aged, 80 and over, Medicine(all), education.field_of_study, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, Incidence, Mortality rate, Incidence (epidemiology), Pain Research, Neglected Diseases, Alcohol dependence, General Medicine, Middle Aged, Global burden of disease, Global Burden of Disease Study 2013 Collaborators, Mental Health, Infectious Diseases, Attention deficit/Hyperactivity disorder, Burden of Illness, Child, Preschool, Acute Disease, Female, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Adolescent, GBD 2013, Population, acute and chronic diseases, Young Adult, Mental-disorders, Age Distribution, Medicine, General & Internal, Weights, General & Internal Medicine, medicine, Humans, Life Science, Disabled Persons, Sex Distribution, Preschool, education, Developing Countries, VLAG, Aged, Science & Technology, business.industry, Developed Countries, Cutaneous Leishmaniasis, Infant, Newborn, Infant, Health outcomes, Newborn, medicine.disease, Comorbidity, Brain Disorders, years lived with disability, Good Health and Well Being, Disease, injury, incidence, prevalence, YLDs, GBD 2010, Chronic Disease, Wounds and Injuries, business, 2.4 Surveillance and distribution, Iron-deficiency, Demography
Abstract

Summary Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation. Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation.

Published
2015

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