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OBJECTIVE: To assess visual outcome and post-operative complications after silicone oil removal in pseudophakic vitrectomized patients. METHODS: This interventional case series study was conducted at Department of Ophthalmology, Medical Teaching Institution Lady Reading Hospital, Peshawar, Pakistan from February 2019 to January 2020. A total of 32 eyes of 32 patients were enrolled in the study after fulfilling inclusion and exclusion criteria using nonrandom consecutive sampling technique. All patients had pars plana vitrectomy with silicone oil done 6 months ago and were pseudophakic. Silicone oil removal was carried out in all patients and visual outcome and surgical complications assessed on 1st and 14th post-operative day. Final examination was done after six months. Statistical analysis was done by using Statistical Package for Social Sciences (version 21) by applying paired sample t-test. RESULTS: Amongst 32 patients, 20 (62.5%) were male and 12 (37.5%) were female. Age of the patients ranged from 16 to 60 years with a mean age of 35±13.97 years. Pre operatively mean best corrected visual acuity (BCVA) was 1.45±0.52 Log Mar. On the last post-operative follow up after six months mean BCVA was 1.21±0.55 Log Mar. Visual acuity improved in 24 (75%), remained stable in 3 (9.4%) and worsening in visual acuity was seen in five (15.6%) cases. Visual improvement was statistically significant (p-value 0.001) using paired ttest. Most common complications were retinal detachment (n=4: 12.5%), secondary glaucoma (n=4: 12.5%) and epi-retinal membrane (n=2; 6.3%). CONCLUSION: Vision improves in majority of pseudophakic patients after silicone oil removal. [ABSTRACT FROM AUTHOR]