29 results on '"Orzalesi, N."'
Search Results
2. Comparison of Compass and Humphrey perimeters in detecting glaucomatous defects.
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Fogagnolo P, Modarelli A, Oddone F, Digiuni M, Montesano G, Orzalesi N, and Rossetti L
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- Aged, Aged, 80 and over, Female, Glaucoma physiopathology, Humans, Male, Middle Aged, Optic Nerve Diseases physiopathology, Scotoma diagnosis, Sensitivity and Specificity, Visual Fields physiology, Glaucoma diagnosis, Optic Nerve Diseases diagnosis, Visual Field Tests instrumentation
- Abstract
Purpose: To compare the performance of Compass fundus automated perimetry (FAP) and Humphrey Field Analyzer (HFA) in glaucoma patients., Methods: A total of 120 patients with glaucoma underwent 1 FAP and 1 HFA perimetric test over the central 24° on one eye. The chosen eye and sequence were randomized and only reliable examinations were considered for analysis. Mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI), and the area of absolute scotoma were compared between perimeters. Glaucoma Staging System (GSS2) data were analyzed by means of k test., Results: Mean sensitivity difference (FAP-HFA) was -1.0 ± 2.81 dB (p<0.001, 95% confidence interval [CI] -1.61, -0.60 dB), MD difference was +0.27 ± 2.84 dB (p = 0.36, 95% CI -5.30, 5.83 dB), PSD difference was +0.48 ± 1.95 dB (p = 0.0075, 95% CI -3.37, 4.33 dB), and VFI difference was +2.4% ± 8.4% (p = 0.003, 95% CI -14.0%, +18.8% dB). Weighted kappa for GSS2 was 0.87. Points with null sensitivities were 9.9 ± 10.2 with FAP and 8.2 ± 8.9 with HFA (difference: 1.7 ± 4.0 points, p = 0.013)., Conclusions: Mean sensitivity with FAP is 1 dB lower than HFA, a finding due to different threshold strategies. Differences of global indices for FAP and HFA are small, which makes the 2 perimeters equivalent in the clinical setting. However, FAP seems more severe in evaluating glaucomatous damage, with absolute scotoma areas larger than with HFA. We raise the hypothesis that such difference may be the result of the active compensation of eye movements available with FAP.
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- 2016
- Full Text
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3. Compass: clinical evaluation of a new instrument for the diagnosis of glaucoma.
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Rossetti L, Digiuni M, Rosso A, Riva R, Barbaro G, Smolek MK, Orzalesi N, De Cilla' S, Autelitano A, and Fogagnolo P
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- Adult, Aged, Aged, 80 and over, Algorithms, Automation, Databases, Factual, Female, Humans, Male, Middle Aged, Visual Fields, Glaucoma diagnosis, Ophthalmoscopy methods, Visual Field Tests methods
- Abstract
Aims: To evaluate Compass, a new instrument for glaucoma screening and diagnosis that combines scanning ophthalmoscopy, automated perimetry, and eye tracking., Materials and Methods: A total of 320 human subjects (200 normal, 120 with glaucoma) underwent full ophthalmological evaluation and perimetric evaluation using the Humphrey SITA standard 24° test (HFA), and the Compass test that consisted of a full-threshold program on the central 24° with a photograph of the central 30° of the retina. A subgroup of normal subjects and glaucoma patients underwent a second Compass test during the same day in order to study test-retest variability. After exclusion of 30 patients due to protocol rules, a database was created to compare the Compass to the HFA, and to evaluate retinal image quality and fixation stability., Results: The difference in mean sensitivity between Compass and HFA was -1.02 ± 1.55 dB in normal subjects (p<0.001) and -1.01 ± 2.81 dB in glaucoma (p<0.001). Repeatability SD for the average sensitivity was 1.53 for normal subjects and 1.84 for glaucoma. Test time with the Compass was 634±96 s (607±78 for normals, 678±108 for glaucoma). Compass analysis showed the percentage of fixation within the central 1° was 86.6% in normal subjects, and 79.3% in glaucoma patients. Color image quality was sufficient for diagnostic use in >65% of cases; Image-based diagnosis was in accordance with the initial diagnosis in 85% of the subjects., Conclusions: Based on preliminary results, Compass showed useful diagnostic characteristics for the study of glaucoma, and combined morphological information with functional data.
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- 2015
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4. Authors' response.
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Fogagnolo P, Sangermani C, Oddone F, Frezzotti P, Iester M, Figus M, Ferreras A, Romano S, Gandolfi S, Centofanti M, Rossetti L, and Orzalesi N
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- Female, Humans, Male, Glaucoma physiopathology, Intraocular Pressure physiology, Ocular Hypertension physiopathology, Visual Field Tests methods, Visual Fields physiology
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- 2011
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5. Long-term perimetric fluctuation in patients with different stages of glaucoma.
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Fogagnolo P, Sangermani C, Oddone F, Frezzotti P, Iester M, Figus M, Ferreras A, Romano S, Gandolfi S, Centofanti M, Rossetti L, and Orzalesi N
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- Adult, Aged, Aged, 80 and over, Disease Progression, Female, Glaucoma diagnosis, Humans, Male, Middle Aged, Ocular Hypertension diagnosis, Retrospective Studies, Glaucoma physiopathology, Intraocular Pressure physiology, Ocular Hypertension physiopathology, Visual Field Tests methods, Visual Fields physiology
- Abstract
Aim: To evaluate the long-term perimetric fluctuation (LF) in patients with different stages of glaucoma according to the Glaucoma Staging System 2 (GSS2)., Methods: This multicentre retrospective study included 161 eyes of 161 stable glaucoma patients undergoing four visual-field tests (Humphrey SITA-Standard program over the central 24° or 30°) over a 2-year period. For each patient, the stage of the disease was classified according to GSS2. LF was then calculated as the mean of the standard deviations of point-to-point threshold sensitivities in the four repetitions. LF in GSS2 stages was compared using the t test. Results LF progressively increased from stage 0 to stage 4, and then decreased at stage 5. Stage 4 had a peak of 3.19 ± 0.94 dB, with statistically significant differences compared with all the other stages. The lowest LF (1.65 ± 0.60 dB) was found for normal subjects, whereas similar data were found for borderline patients and those at stages 1 and 5 (2.09 ± 0.58, 2.13 ± 0.57 and 2.22 ± 0.89 dB, respectively; p > 0.13). Visual fields with generalised defects had a lower LF (1.90 ± 0.81) than those with mixed (2.84 ± 0.87, p = 0.0003) and localised (2.63 ± 0.72, p = 0.004) defects. Conclusions In this study, the authors showed that the lower the visual-field defect, the lower was LF, except at stage 5 of GSS2. As test-retest changes exceeding LF could represent a sign of progression, the authors suggest that clinicians using this classification system calculate LF, in order to better differentiate true progression from variability.
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- 2011
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6. Short-wavelength automated perimetry and frequency-doubling technology perimetry in glaucoma.
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Fogagnolo P, Rossetti L, Ranno S, Ferreras A, and Orzalesi N
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- Disease Progression, Humans, Retinal Ganglion Cells classification, Retinal Ganglion Cells pathology, Retinal Ganglion Cells physiology, Software, Visual Fields physiology, Glaucoma diagnosis, Glaucoma pathology, Glaucoma physiopathology, Visual Field Tests instrumentation, Visual Field Tests methods
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Standard automated perimetry (SAP) is today still the clinical standard for the management of glaucoma and its progression, though it has been shown that it may detect the disease only after the death of a high number of retinal ganglion cells (RGCs). A number of "unconventional" perimetries have recently been evaluated by several clinical studies which showed their ability to identify the earliest glaucoma changes; the most promising of these techniques are short-wavelength automated perimetry (SWAP) and frequency-doubling technology perimetry (FDT). The applicability of these techniques is still limited by a number of factors: the limited economic resources allocated to perimetry; the paucity of well-conducted, prospective longitudinal studies showing the superiority of SWAP and FDT over SAP; and the lack of a consensus on the criteria to define test abnormality with these techniques. The aim of this article is to review the rationale, the limits, and the potentiality of SWAP and FDT for glaucoma management and to summarize the tasks required to improve the clinical usefulness of these two instruments in the future.
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- 2008
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7. Direct costs of glaucoma and severity of the disease: a multinational long term study of resource utilisation in Europe.
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Traverso CE, Walt JG, Kelly SP, Hommer AH, Bron AM, Denis P, Nordmann JP, Renard JP, Bayer A, Grehn F, Pfeiffer N, Cedrone C, Gandolfi S, Orzalesi N, Nucci C, Rossetti L, Azuara-Blanco A, Bagnis A, Hitchings R, Salmon JF, Bricola G, Buchholz PM, Kotak SV, Katz LM, Siegartel LR, and Doyle JJ
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- Adult, Age Distribution, Aged, Aged, 80 and over, Drug Costs statistics & numerical data, Europe, Female, Follow-Up Studies, Glaucoma physiopathology, Glaucoma therapy, Humans, Male, Middle Aged, Office Visits economics, Severity of Illness Index, Sex Distribution, Visual Fields, Glaucoma economics, Health Care Costs statistics & numerical data, Health Resources statistics & numerical data
- Abstract
Background: Resource utilisation and direct costs associated with glaucoma progression in Europe are unknown. As population progressively ages, the economic impact of the disease will increase., Methods: From a total of 1655 consecutive cases, the records of 194 patients were selected and stratified by disease severity. Record selection was based on diagnoses of primary open angle glaucoma, glaucoma suspect, ocular hypertension, or normal tension glaucoma; 5 years minimum follow up were required. Glaucoma severity was assessed using a six stage glaucoma staging system based on static threshold visual field parameters. Resource utilisation data were abstracted from the charts and unit costs were applied to estimate direct costs to the payer. Resource utilisation and estimated direct cost of treatment, per person year, were calculated., Results: A statistically significant increasing linear trend (p = 0.018) in direct cost as disease severity worsened was demonstrated. The direct cost of treatment increased by an estimated 86 for each incremental step ranging from 455 euro per person year for stage 0 to 969 euro per person year for stage 4 disease. Medication costs ranged from 42% to 56% of total direct cost for all stages of disease., Conclusions: These results demonstrate for the first time in Europe that resource utilisation and direct medical costs of glaucoma management increase with worsening disease severity. Based on these findings, managing glaucoma and effectively delaying disease progression would be expected to significantly reduce the economic burden of this disease. These data are relevant to general practitioners and healthcare administrators who have a direct influence on the distribution of resources.
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- 2005
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8. The effects of antiglaucoma and systemic medications on ocular blood flow.
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Costa VP, Harris A, Stefánsson E, Flammer J, Krieglstein GK, Orzalesi N, Heijl A, Renard JP, and Serra LM
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- Eye metabolism, Glaucoma physiopathology, Humans, Pharmacokinetics, Pharmacology, Regional Blood Flow drug effects, Eye blood supply, Glaucoma drug therapy
- Abstract
Based on the body of evidence implicating ocular blood flow disturbances in the pathogenesis of glaucoma, there is great interest in the investigation of the effects of antiglaucoma drugs and systemic medications on the various ocular vascular beds. The primary aim of this article was to review the current data available on the effects of antiglaucoma drugs and systemic medications on ocular blood flow. We performed a literature search in November 2002, which consisted of a textword search in MEDLINE for the years 1968-2002. The results of this review suggest that there is a severe lack of well-designed long-term studies investigating the effects of antiglaucoma and systemic medications on ocular blood flow in glaucomatous patients. However, among the 136 articles dealing with the effect of antiglaucoma drugs on ocular blood flow, only 36 (26.5%) investigated the effects of medications on glaucoma patients. Among these 36 articles, only 3 (8.3%) were long-term studies, and only 16 (44.4%) were double-masked, randomized, prospective trials. Among the 33 articles describing the effects of systemic medications on ocular blood flow, only 11 (33.3%) investigated glaucoma patients, of which only one (9.1%) was a double-masked, randomized, prospective trial. Based on this preliminary data, we would intimate that few antiglaucoma medications have the potential to directly improve ocular blood flow. Unoprostone appears to have a reproducible antiendothelin-1 effect, betaxolol may exert a calcium-channel blocker action, apraclonidine consistently leads to anterior segment vasoconstriction, and carbonic anhydrase inhibitors seem to accelerate the retinal circulation. Longitudinal, prospective, randomized trials are needed to investigate the effects of vasoactive substances with no hypotensive effect on the progression of glaucoma.
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- 2003
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9. The impact of ocular blood flow in glaucoma.
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Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, and Stefánsson E
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- Glaucoma etiology, Humans, Intraocular Pressure, Regional Blood Flow, Vascular Diseases complications, Eye blood supply, Glaucoma physiopathology
- Abstract
Two principal theories for the pathogenesis of glaucomatous optic neuropathy (GON) have been described--a mechanical and a vascular theory. Both have been defended by various research groups over the past 150 years. According to the mechanical theory, increased intraocular pressure (IOP) causes stretching of the laminar beams and damage to retinal ganglion cell axons. The vascular theory of glaucoma considers GON as a consequence of insufficient blood supply due to either increased IOP or other risk factors reducing ocular blood flow (OBF). A number of conditions such as congenital glaucoma, angle-closure glaucoma or secondary glaucomas clearly show that increased IOP is sufficient to lead to GON. However, a number of observations such as the existence of normal-tension glaucoma cannot be satisfactorily explained by a pressure theory alone. Indeed, the vast majority of published studies dealing with blood flow report a reduced ocular perfusion in glaucoma patients compared with normal subjects. The fact that the reduction of OBF often precedes the damage and blood flow can also be reduced in other parts of the body of glaucoma patients, indicate that the hemodynamic alterations may at least partially be primary. The major cause of this reduction is not atherosclerosis, but rather a vascular dysregulation, leading to both low perfusion pressure and insufficient autoregulation. This in turn may lead to unstable ocular perfusion and thereby to ischemia and reperfusion damage. This review discusses the potential role of OBF in glaucoma and how a disturbance of OBF could increase the optic nerve's sensitivity to IOP.
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- 2002
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10. Diagnostic value for glaucoma of a new HRT analysis correcting for disc size.
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Miglior S, Guareschi M, Zanchi S, Casula M, Albe' E, Fontana L, and Orzalesi N
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- Humans, Sensitivity and Specificity, Software, Tomography methods, Visual Fields, Diagnostic Techniques, Ophthalmological instrumentation, Glaucoma diagnosis, Optic Disk pathology, Optic Nerve Diseases diagnosis
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- 2002
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11. Temporal corneal phacoemulsification combined with separate-incision superior trabeculectomy vs standard phacotrabeculectomy. A comparative study.
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Rossetti L, Bucci L, Miglior S, and Orzalesi N
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- Adult, Aged, Aged, 80 and over, Cataract complications, Female, Follow-Up Studies, Glaucoma complications, Humans, Intraocular Pressure, Male, Middle Aged, Postoperative Complications, Treatment Outcome, Visual Fields, Cornea surgery, Glaucoma surgery, Phacoemulsification methods, Trabeculectomy methods
- Abstract
The aim of the study was to compare functional and refractive outcome after temporal approach phacoemulsification combined with superior trabeculectomy against that of standard superior phacotrabeculectomy in patients affected by cataract and uncontrolled glaucoma. Fifty patients undergoing combined surgery were randomly allocated to receive either a standard superior phacotrabeculectomy (group A) or a temporal via clear cornea phacoemulsification combined with a separate superior trabeculectomy (group B). Short-term and long-term mean IOP reductions were similar in the two groups though, at 2 years, more patients in the standard phacotrabeculectomy group had need of medical therapy to control their ocular pressure (p = 0.04). Group B had less surgically induced astigmatism than group A (p = 0.05). There was no significant difference in ocular inflammation and complication rates between the 2 groups.
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- 1997
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12. Technical procedures and software for magnification-corrected morphometry of optic disk photography.
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Brigatti L, Bottoni F, Miglior S, and Orzalesi N
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- Humans, Image Processing, Computer-Assisted, Photography, Vision Tests methods, Glaucoma diagnosis, Optic Disk pathology, Software
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In order to obtain a new diagnostic tool for the early diagnosis of glaucoma, we developed a method based on computerized analysis of the optic disk, cup and neuroretinal rim areas. A fundus camera, a personal computer and a graphic tablet are employed. Suitable software was developed for calculating the areas (disk, cup and rim) providing an index, the rim/disk ratio. The method revealed high repeatability and reproducibility. The simplicity and speed of the procedure make this test suitable for routine clinical use in the early diagnosis of glaucoma.
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- 1991
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13. [Research on the changes of the chamber angle ultrastructure in glaucoma].
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Boles Carenini B and Orzalesi N
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- Aged, Female, Humans, Male, Microscopy, Electron, Middle Aged, Tonometry, Ocular, Anterior Chamber pathology, Glaucoma pathology
- Published
- 1967
14. [Observations on 5 cases of mesodermic dysgenesis of the cornea and iris in 3 generations of the same family].
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Boles Carenini B and Orzalesi N
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- Adolescent, Adult, Aged, Female, Humans, Iris abnormalities, Male, Middle Aged, Cataract genetics, Cornea abnormalities, Glaucoma genetics
- Published
- 1966
15. Vascular risk factors in glaucoma: the results of a national survey
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Orzalesi, N., Rossetti, L., Omboni, S., OPTIME study group, Sborgia, C, Vetrugno, M, Cantatore, F, Campos, E, Baldi, A, Quaranta, Luciano, University of Cagliari, University of Catania Uva, M, Longo, A, Lombardo, A, Scorcia, G, Moschettini, R, Gallenga, Pe, Mastropasqua, L, Ciancaglini, M, Carpineto, P, Lobefalo, L, University of Ferrara, University of Firenze (Alfieri, G, Menchini, U, Campana, F, Giansanti, F, Delle Noci, N, Balducci, F, Calabria, G, Saccà, S, Sanna, G, Camicione, P, Mastromarino, A, Balestrazzi, E, Di Staso, S, Ferreri, G, D’Andrea, A, Orzalesi, N, Rossetti, L, Fogagnolo, P, Mazzolani, F, Brancato, R, Carassa, R, Bettin, P, Fiori, M, Guerra, R, Martini, E, Scarale, G, Campi, L, Bonavolontà, G, Rinaldi, E, Di Meo, A, Fusco, R, Dorigo, Mt, Doro, D, Grgic, V, Lodato, G, Morreale Bubella, D, Signorelli, F, Gandolfi, S, Trimarchi, F, Milano, G, Fiore, C, De Carolis, A, Sbordone, G, Nardi, M, Bartolomei, Mp, Figus, M, Guidi, G, Scullica, L, Salgarello, T, Colotto, A, Bucci, Mg, Cerulli, L, Manni, Gl, Centofanti, M, Parravano, M, Scuderi, G, Nucci, C, Carta, F, Pinna, A, Caporossi, A, Frezzotti, P, Grignolo, F, Brogliatti, B, Rolle, T, Ravalico, G, Vattovani, O, Tritto, D, Canziani, T, Marchini, G, and Marraffa, M.
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glaucoma ,genetic structures ,risk factors ,sense organs ,eye diseases - Published
- 2007
16. Vascular risk factors in glaucoma: The results of a national survey
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Orzalesi, N, Rossetti, L., Omboni, S., Sborgia, C., Vetrugno, M., Cantatore, F., Campos, E., Baldi, A., Quaranta, L., Serra, A., Zucca, I., Mura, M., Malocci, M., Uva, M., Longo, A., Lombardo, A., Scorcia, G., Moschettini, R., Gallenga, P. E., Mastropasqua, L, Ciancaglini, Marco, Carpineto, P., Lobefalo, L., Perri, P., Paduano, B., Alfieri, G., Menchini, U., Campana, F., Giansanti, F., Delle, Noci, Balducci, N., Calabria, F., Saccà, G., Sanna, S., Camicione, G., Mastromarino, P., Balestrazzi, A., DI STASO, Silvio, Ferreri, S., D’Andrea, G., Orzalesi, A., Rossetti, N., Fogagnolo, L., Mazzolani, P., Brancato, F., Carassa, R., Bettin, R., Fiori, P., Guerra, M., Martini, R., Scarale, E., Campi, G., Bonavolontà, L., Rinaldi, G., Meo, Di, Fusco, A., Dorigo, R., Doro, M. T., Grgic, D., Lodato, V., Morreale, Bubella, Signorelli, D., Gandolfi, F., Trimarchi, S., Milano, F., Fiore, G., Carolis, De, Sbordone, A., Nardi, G., Bartolomei, M., Figus, M. P., Guidi, M., Scullica, G., Salgarello, L., Colotto, T., Bucci, A., Cerulli, M. G., Manni, L., Centofanti, G. L., Parravano, M., Scuderi, M., Nucci, G., Carta, C., Pinna, F., Caporossi, A., Frezzotti, A., Grignolo, P., Brogliatti, F., Rolle, B., Ravalico, T., Vattovani, G., Tritto, O., Canziani, D., Marchini, T., Marraffa, G., ORZALESI N, ROSSETTI L, OMBONI S, LODATO G, and COMPROSO
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Male ,medicine.medical_specialty ,Intraocular pressure ,genetic structures ,Diastole ,Glaucoma ,Blood Pressure ,Risk factors ,Survey ,Aged ,Cardiovascular Diseases ,Family Health ,Female ,Glaucoma, Open-Angle ,Humans ,Intraocular Pressure ,Italy ,Risk Factors ,Surveys and Questionnaires ,Visual Fields ,Health Surveys ,Ophthalmology ,Sensory Systems ,Cellular and Molecular Neuroscience ,NO ,Settore MED/30 ,medicine ,Medical history ,Family history ,Settore MED/30 - Malattie Apparato Visivo ,business.industry ,Intraocular pressure, Glaucoma ,Odds ratio ,medicine.disease ,eye diseases ,Blood pressure ,Open-Angle ,Population study ,sense organs ,business - Abstract
Background The role of vascular risk factors in glaucoma is still being debated. To assess the importance of vascular risk factors in patients with primary open-angle glaucoma (POAG), data from the medical history of 2,879 POAG patients and 973 age-matched controls were collected and analyzed. Methods Design: observational survey. Setting: 35 Italian academic centers. Study population: POAG patients and age-matched controls. In order to reduce bias consecutive patients were included. Observation procedures: data concerning vascular risk factors were collected for all patients with a detailed questionnaire. A complete ophthalmological examination with assessment of intraocular pressure (IOP), visual field, optic disc, and systemic blood pressure was performed. Main outcome measures: the ESH-ESC (European Society of Hypertension-European Society of Cardiology) guidelines were used to calculate the level of cardiovascular risk. Crude and adjusted estimates of the odds ratios (OR) were calculated for all cardiovascular risk factors in POAG and controls. Results The study included 2,879 POAG patients and 973 controls. POAG cases had a significantly higher systolic and diastolic blood pressure (p=0.001) and systolic perfusion pressure (p=0.02) as compared with controls. Also mean IOP was significantly higher in the POAG group (p=0.01), while diastolic perfusion pressure was not significantly different in the two groups. Myopia was more prevalent in the POAG group (23 vs 18%, p=0.005) as well as a positive family history for glaucoma (26 vs 12%, p= 0.004). POAG patients tended to have a higher cardiovascular risk than controls: 63% of glaucoma cases vs 55% of controls (OR: 1.38, p=0.005) had a “high” or “very high” cardiovascular risk. Conclusions The level of cardiovascular risk was significantly higher in glaucoma patients than in controls.
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- 2007
17. Central corneal thickness in the European Glaucoma Prevention Study
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Pfeiffer, N, Torri, V, Miglior, S, Zeyen, T, Adamsons, I, Cunha-Vaz, J, Linsen, Mc, Pellicci, L, Janssens, A, van der Veken, A, Nerinckx, F, Boeyden, V, Kestelijn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Marini, G, Centofanti, M, Cocco, F, Glorialanza, G, Villani, Cm, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Pereira, Jm, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Silva, Jp, Romano, G, Silva, S, Floriani, I, Poli, D, Tinazzi, A, Caprioli, J, Wormald, R, Hejil, A, Airaksinen, J, Michaelis, J, Mandelli, La, Bagno, S, Shedden, A, Gottfried, E, Hutzelmann, J, Rusk, C, Reines, S, Spector, R, Hombrey, J, Snyder, H, Gacos, J, Snapinn, S, Getson, A, Amos, J, Serruys, K, Malbecq, W, John, E, Chapman, J, Beck, J, Tessi, C, Rao, N, Bottari, Fp, D'Achille, R, Wilkins, A, Magerl, K, Bauer, C, Derouwaux, C, Cunha, M, Santana, R, Andrade, Lg, Bule, S, Melo, R, Baumont, H, Bonaventura, I, Pfeiffer, N, Torri, V, Miglior, S, and The European Glaucoma Prevention Study, G
- Subjects
Adult ,Male ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Settore MED/06 - Oncologia Medica ,Glaucoma, ocular hypertension, central corneal thickness ,Ocular hypertension ,Glaucoma ,Thiophenes ,Placebo ,law.invention ,Cornea ,Diabetes Complications ,Sex Factors ,Double-Blind Method ,Randomized controlled trial ,Dorzolamide ,law ,Diabetes mellitus ,Ophthalmology ,medicine ,Humans ,Intraocular Pressure ,Aged ,Ultrasonography ,Sulfonamides ,business.industry ,Age Factors ,Middle Aged ,medicine.disease ,eye diseases ,Surgery ,medicine.anatomical_structure ,Female ,Ocular Hypertension ,sense organs ,business ,medicine.drug - Abstract
Purpose: To measure central corneal thickness (CCT) within the participants of the European Glaucoma Prevention Study (EGPS). This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma. Design: Randomized, double-masked, controlled, observational clinical trial. Participants: Eight hundred fifty-four of 1077 ocular hypertensive participants within the EGPS were investigated. Four hundred twenty-nine patients were treated with dorzolamide and 425 patients received placebo. Intervention: Treatment with dorzolamide or placebo (the vehicle of dorzolamide) in 1 or both eyes. Main Outcome Measures: Central corneal thickness as measured by ultrasound pachymetry (DGH-500 Pachette; DGH Technologies, Exton, PA). The CCT measurements were obtained in the morning before measuring IOP. Five measurements were taken from each eye of each patient within 5 minutes of application of anesthetic eye drops. Results: Mean CCT was 572.6±37.4 μm (range, 458.5-695.6 μm). The CCT was higher in younger patients, male patients, and diabetic patients. Mean CCTs for the 429 patients receiving dorzolamide were 574.2±38.48 μm (range, 458.5-695.6 μm) and 571.0±36.21 μm (469.7-690.1 μm) for the 425 patients receiving placebo (P = 0.205). Central corneal thickness did not correlate with refraction, baseline IOP, or systemic hypertension. Conclusion: Central corneal thickness measurements within the EGPS were greater than those reported in other studies of normal eyes without ocular hypertension. Larger CCT measurements correlated with male gender, younger age, and diabetes. © 2007 American Academy of Ophthalmology.
- Published
- 2007
18. Reproducibility of evaluation of optic disc change for glaucoma with stereo optic disc photographs
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Miglior, S, Zeyen, T, Pfeiffer, N, Cunha-Vaz, J, Linsen, Mc, Pellicci, L, Janssens, A, van der Veken, A, Nerinckx, F, Boeyden, V, Czupper, M, Wendrix, G, Detry-Morel, M, Kestelyn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Deghislage, C, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Marini, S, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Manni, G, Cocco, F, Glorialanza, G, Villani, Cm, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Pereira, Jm, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Silva, Jp, Romano, G, Silva, S, Torri, V, Poli, D, Nerviani, C, Tinazzi, A, Floriani, I, Adamsons, I, Caprioli, J, Wormald, R, Heijl, A, Airaksinen, J, Michaelis, J, Shedden, A, Gottfried, E, Hutzelmann, J, Rusk, C, Reines, S, Spector, R, Hombrey, J, Snyder, H, Gacos, J, Snapinn, S, Getson, A, Amos, J, Serruys, K, Malbecq, W, John, E, Chapman, J, Beck, J, Tessi, C, Rao, N, Bottari, Fp, D'Achille, R, Wilkins, A, Bauer, C, Derouwaux, C, Van der Straeten, A, Cunha, M, Santana, R, Andrade, Lg, Bule, S, Melo, R, Baumont, H, and Bonaventura, I
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medicine.medical_specialty ,genetic structures ,Optic Disk ,Optic disk ,Glaucoma ,Interobserver reproducibility ,Cohen's kappa ,Double-Blind Method ,Ophthalmology ,Optic Nerve Diseases ,medicine ,Photography ,Humans ,Observer Variation ,Reproducibility ,business.industry ,Outcome measures ,Reproducibility of Results ,medicine.disease ,eye diseases ,Confidence interval ,medicine.anatomical_structure ,sense organs ,business ,Optic disc - Abstract
PURPOSE To determine the reproducibility of the assessment for glaucomatous change in serial optic disc stereo-slides. DESIGN Masked interobserver variability study. PARTICIPANTS Serial optic disc stereo-slides from 40 patients. METHODS Three independent ophthalmologists evaluated for change a set of two serial 20 degrees optic disc color stereo-slides of 40 patients. This test set was not from European Glaucoma Prevention Study (EGPS) patients. Each observer performed two evaluations at least 30 days apart and was masked from the temporal sequence of the slides and his or her previous evaluation. Each patient was graded as changed or stable by two-out-of-three agreement. A kappa statistic was used to calculate the intra- and interobserver reproducibility as well as the assignment reproducibility (first consensus versus second consensus). The same procedure was followed to test the reproducibility when another experienced ophthalmologist was added to one of the three reading centers. MAIN OUTCOME MEASURES Reproducibility in evaluating glaucomatous optic disc change. RESULTS The intraobserver reproducibility (95% confidence interval [CI]) in the evaluation of change ranged between 0.79 (0.45-1.14) and 1.00 (0.69-1.31). The interobserver reproducibility (95% CI) in the evaluation of change ranged between 0.45 (0.15-0.75) and 0.75 (0.44-1.06). The assignment reproducibility (first consensus versus second consensus in the evaluation of change) between the senior EGPS readers was 0.94 (0.63-1.25). The assignment reproducibility when another experienced ophthalmologist replaced one of the readers was 0.94 (0.63-1.25). CONCLUSIONS The assignment reproducibility of three expert readers looking for glaucomatous change in serial optic disc stereo-slides was excellent. It remained so when one of the three experts was replaced by another experienced reader.
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- 2003
19. The European glaucoma prevention study design and baseline description of the participants
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Miglior, S, Zeyen, T, Pfeiffer, N, Cunha-Vaz, J, Linsen, Mc, Pellicci, L, Janssens, A, van der Veken, A, Nerinckx, F, Boeyden, V, Detry-Morel, M, Kestelijn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Marini, S, Bagno, S, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Manni, G, Cocco, F, Glorialanza, G, Villani, Cm, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Pereira, Jm, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Silva, Jp, Romano, G, Silva, S, Torri, V, Poli, D, Nerviani, C, Tinazzi, A, Adamsons, I, Caprioli, J, Wormald, R, Hejil, A, Airaksinen, J, Michaelis, J, Floriani, I, Shedden, A, Gottfried, E, Hutzelmann, J, Rusk, C, Reines, S, Spector, R, Hombrey, J, Snyder, H, Gacos, J, Snapinn, S, Getson, A, Amos, J, Serruys, K, Malbecq, W, John, E, Chapman, J, Beck, J, Tessi, C, Rao, N, Bottari, Fp, D'Achille, R, Wilkins, A, Magerl, K, Bauer, C, Derouwaux, C, Cunha, M, Santana, R, Andrade, Lg, Bule, S, Melo, R, Baumont, H, Bonaventura, I, Miglior, S, Zeyen, T, Pfeiffer, N, Cunha Vaz, J, Torri, V, and Adamsons, I
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Adult ,Male ,medicine.medical_specialty ,Intraocular pressure ,Visual acuity ,genetic structures ,Visual Acuity ,Glaucoma ,Ocular hypertension ,Thiophenes ,Sulfonamide ,law.invention ,Visual Field Test ,Randomized controlled trial ,Dorzolamide ,Double-Blind Method ,Thiophene ,law ,Ophthalmology ,medicine ,Humans ,Dioptre ,Antihypertensive Agents ,Intraocular Pressure ,Aged ,Aged, 80 and over ,Sulfonamides ,business.industry ,Middle Aged ,medicine.disease ,eye diseases ,Europe ,Antihypertensive Agent ,medicine.anatomical_structure ,Research Design ,Visual Field Tests ,Female ,Ocular Hypertension ,sense organs ,medicine.symptom ,Safety ,Visual Fields ,business ,Glaucoma, Open-Angle ,Human ,Optic disc ,medicine.drug - Abstract
Objectives The European Glaucoma Prevention Study seeks to evaluate the efficacy of reducing intraocular pressure (IOP), with dorzolamide to prevent or delay patients affected by ocular hypertension from developing primary open-angle glaucoma. Design Randomized, double-blinded, controlled clinical trial. Participants Patients (age > or =30 years) were enrolled from 18 European centers. The patients fulfilled a series of inclusion criteria including the measurements of IOP (22-29 mmHg), two normal and reliable visual fields (VFs) (on the basis of mean defect and corrected pattern standard deviation/corrected loss of variance of standard 30/II Humphrey or Octopus perimetry), and normal optic disc as determined by the Optic Disc Reading Center (vertical and horizontal cup-to-disc ratios; asymmetry between the two eyes Intervention Patients were randomized to the treatment with dorzolamide or a placebo. Main outcome measures End points are VF and/or optic disc changes. A VF change during the follow-up must be confirmed by two further positive tests. Optic disc change is defined by the agreement of two out of three independent observers evaluating optic disc stereo-slides. Results One thousand seventy-seven subjects were randomized between January 1, 1997 and May 31, 1999. The mean age was 57.03 +/- 10.3 years; 54.41% were women and 99.9% were Caucasian. Mean IOP was 23.6 +/- 1.6 mmHg in both eyes. Mean visual acuity was 0.97 +/- 0.11 in both eyes; mean refraction was 0.23 +/- 1.76 diopters in the right eye and 0.18 +/- 1.79 diopters in the left eye. Previous use of medication for ocular hypertension was reported by 38.4% of the patients, systemic hypertension by 28.1%, cardiovascular diseases by 12.9%, and diabetes mellitus by 4.7%. The qualifying VFs were normal and reliable according to protocol criteria. Conclusions The mean IOP of the patients enrolled in the European Glaucoma Prevention Study is consistent with the estimated mean IOP (within the range of 22-29 mmHg) found in a large sample of the European population. The European Glaucoma Prevention Study should be able to better address the clinical question of whether pharmacological reduction of IOP (by means of dorzolamide) in ocular hypertension patients at moderate risk for developing primary open-angle glaucoma effectively lowers the incidence of primary open-angle glaucoma.
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- 2002
20. Testâretest variability of intraocular pressure and ocular pulse amplitude for dynamic contour tonometry: a multicentre study.
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Fogagnolo, P., Figus, M., Frezzotti, P., Iester, M., Oddone, F., Zeppieri, M., Ferreras, A., Brusini, P., Rossetti, L., and Orzalesi, N.
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INTRAOCULAR pressure ,TONOMETRY ,TONOMETERS ,GLAUCOMA ,RANDOMIZED controlled trials - Abstract
Aims To assess the testeretest variability of intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements utilising dynamic contour tonometry (DCT) and to evaluate possible influential factors. Methods The study included 350 consecutive subjects (175 glaucoma, 175 control; one eye per subject) from seven European centres. IOP was measured once with a Goldmann applanation tonometer (GAT) and twice by DCT (DCT1, DCT2) in a randomised sequence. OPA was also recorded for both DCT measurements. Differences (DCT1-DCT2; OPA1-OPA2; GAT-DCT1; GAT-DCT2) were assessed using the t test. The intraclass coefficient of correlation (ICC) and coefficient of variation (CoV) for DCT and OPA were calculated. Results DCT1 was 0.661.6 mmHg higher than DCT2 (p<0.001); OPA1 was 0.1±0.7 mm Hg higher than OPA2 (p=0.02). Results were not influenced by randomisation test order. In both glaucoma and normal subjects, DCT and OPA showed ICC>0.90 and >0.76, and CoV=4.8-5.0% and 10.3-10.5%, respectively. DCT1 and 2 were 2.4±2.6 and 1.8±2.6 mmHg higher respectively than GAT (p<0.001). Discussion DCT testeretest variability was almost perfect for IOP and good for OPA. Tonometry measurements with DCT tended to be overestimated compared with GAT. [ABSTRACT FROM AUTHOR]
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- 2010
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21. Circadian variations in central corneal thickness and intraocular pressure in patients with glaucoma.
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Fogagnolo, P., Rossetti, L., Mazzolani, F., and Orzalesi, N.
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GLAUCOMA ,MYOPIA ,INTRAOCULAR pressure ,EYE diseases ,TONOMETERS ,PATIENTS - Abstract
Aim: To analyse 24 hour variations in intraocular pressure (IOP) and central corneal thickness (CCT) in a group of glaucomatous patients. Methods: 30 patients with primary open angle glaucoma were hospitalised and underwent circadian evaluations (at 8 pm, midnight, 4 am, 8 am, noon, and 4 pm) of supine and sifting IOP, respectively, measured using a Perkins and a Goldmann tonometer, and CCT measured using an ultrasonic pachymeter (the mean value of three measurements within 5 μm). All patients were treated with timolol 0.5% twice daily and latanoprost 0.005% once daily. Results: Mean supine IOP was 15.3 (SD 3.7) mm Hg (range 10-25), with circadian fluctuations of 7.3 (3.3) mm Hg. Mean sifting lop was 15.1(3.9) mm Hg (range 8-26), with circadian fluctuations of 5.4 (3.1) mm Hg. Mean CCT was 534 (39) μm (range 443-637 μm) with circadian fluctuations of 16.5 (6.2) μm (range 6-31 μm). Both the within patient and within time point fluctuations in CCT were statistically significant (p<0.0001, ANOVA). Conclusions: The authors found considerable fluctuations in 24 hour IOP. The circadian fluctuations in CCT were small and, although statistically significant, did not seem to interfere with the circadian IOP assessment. [ABSTRACT FROM AUTHOR]
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- 2006
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22. The Impact of Definition of Primary Open-angle Glaucoma on the Cross-sectional Assessment of Diagnostic Validity of Heidelberg Retinal Tomography
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Valter Torri, Magda Guareschi, Stefano Miglior, Elena Albè, Nicola Orzalesi, Filippo Romanazzi, Miglior, S, Guareschi, M, Romanazzi, F, Albe’, E, Torri, V, and Orzalesi, N
- Subjects
Adult ,Male ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Open angle glaucoma ,Cross-sectional study ,Eye disease ,Optic Disk ,Optic disk ,Glaucoma ,Sensitivity and Specificity ,Ophthalmology ,Optic Nerve Diseases ,Humans ,Medicine ,Tomography ,Intraocular Pressure ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Reproducibility of Results ,Retrospective cohort study ,Middle Aged ,medicine.disease ,eye diseases ,Visual field ,Ophthalmoscopy ,Cross-Sectional Studies ,glaucoma definition, confocal scanning laser ophthalmoscopy ,Female ,Ocular Hypertension ,sense organs ,Visual Fields ,business ,Glaucoma, Open-Angle - Abstract
• PURPOSE: To evaluate the impact of different definitions of primary open angle glaucoma (POAG) on assessment of the diagnostic validity of Heidelberg Retinal Tomography (HRT). • DESIGN: Retrospective, cross-sectional study. • METHODS: A search of medline (1992-2003) led to the retrieval of 181 papers containing definitions of POAG, including the eight visual field (VF)-based definitions used for this study. A sample of 193 normal subjects, 222 patients with suspected POAG, and 103 with POAG underwent HRT and the 24 II Humphrey VF examinations to assess the diagnostic validity of HRT. POAG was defined on the basis of Glaucoma Hemifield Test (GHT) "out of normal limits" associated with corrected pattern standard deviation (CPSD) > 2 dB and intraocular pressure (IOP)
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- 2005
23. Intraobserver and interobserver reproducibility in the evaluation of optic disc stereometric parameters by Heidelberg retina tomograph
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Luca Rossetti, Nicola Orzalesi, Magda Guareschi, Stefano Miglior, Elena Albè, Miglior, S, Albé, E, Guareschi, M, Rossetti, L, and Orzalesi, N
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Adult ,medicine.medical_specialty ,Intraclass correlation ,Optic Disk ,Optic disk ,Laser ,Reproducibility of Result ,Glaucoma ,Interobserver reproducibility ,Standard deviation ,Ophthalmoscopy ,Optic Nerve Disease ,Optic Nerve Diseases ,medicine ,Humans ,Tomography ,Aged ,Observer Variation ,Reproducibility ,medicine.diagnostic_test ,business.industry ,Lasers ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Surgery ,Ophthalmology ,medicine.anatomical_structure ,Nuclear medicine ,business ,Glaucoma, Open-Angle ,Human ,Optic disc - Abstract
Purpose: To assess intraobserver and interobserver reproducibility of the measurement of stereometric parameters of the optic disc by means of the Heidelberg Retina Tomograph I (HRT). Study design: Observational study, with interobserver variability. Participants: Fifty-five volunteers (healthy subjects and patients with glaucoma). Methods: HRT examination of the optic disc was repeated on 3 consecutive days on 1 eye of each of the 55 subjects. During each session, five single images were randomly acquired by two independent observers. One mean topography image (MTI), based on three single images, was then built at each session. For the intraobserver intraimage evaluation, the two observers traced their own contour line on one randomly chosen MTI. This procedure was repeated three times. For the intraobserver interimage and interobserver intra/interimage evaluations, the two observers traced their own contour line on the MTI of the first session, which was then automatically superimposed on the MTIs of the other two sessions. Main Outcome Measures: Reproducibility of the 12 stereometric parameters was calculated for each observer by means of the intraclass correlation coefficient (ICC). The expected range of variability between two independent evaluations was calculated by the scatter-plots of each test-retest difference versus their mean. The standard deviation of the mean test-retest score differences was used to describe the spread of score differences. Results: The ICC ranged between 0.79 and 0.99 for intraobserver intraimage and between 0.56 and 1 for intraobserver interimage evaluation. The ICC ranged between 0.54 and 0.99 for interobserver intraimage and between 0.65 and 0.97 for the interobserver interimage evaluation. ICC was almost perfect to perfect for planimetric measures (0.81 < ICC ≤ 1), substantial to almost perfect for volumetric and cup measures (0.61 < ICC ≤ 0.99), and moderate to almost perfect for retinal nerve fiber layer related measures (0.41 < ICC < 0.99). The expected variability was low (95% confidence interval
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- 2002
24. The learning effect of short-wavelength automated perimetry in patients with ocular hypertension
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Stefano Miglior, Michele Vetrugno, Marco Centofanti, Nicola Orzalesi, Paolo Fogagnolo, Luca Rossetti, Rossetti, L, Fogagnolo, P, Miglior, S, Centofanti, M, Vetrugno, M, and Orzalesi, N
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Male ,medicine.medical_specialty ,Vision Disorders ,Ocular hypertension ,Glaucoma ,Learning effect ,Early glaucoma ,Short-wavelength automated perimetry ,Short wavelength automated perimetry ,Ophthalmology ,Glaucoma, SWAP ,Medicine ,Humans ,Learning ,In patient ,Simulation ,business.industry ,Settore MED/30 - Malattie Apparato Visivo ,Middle Aged ,medicine.disease ,Peripheral ,Visual Field Tests ,Female ,Ocular Hypertension ,Analysis of variance ,Visual Fields ,business - Abstract
AIM: To evaluate the learning effect of short-wavelength automated perimetry (SWAP) on a group of patients with ocular hypertension experienced with standard automated perimetry (SAP). METHODS: Thirty patients with ocular hypertension underwent 5 full-threshold SWAP tests at intervals of 7±2 days. The parameters investigated to detect a learning effect were duration, the perimetric indices, and the number of points with a P of
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- 2006
25. 'Myocilin Gln368stop mutation and advanced age as risk factors for late-onset primary open-angle glaucoma'
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Nicola Orzalesi, Paolo Gasparini, Giuseppina Casu, Luciano Bonomi, Leopoldo Zelante, Mario Pirastu, Andrea Angius, Giuseppe Ghilotti, Patrizia Spinelli, Angela Loi, Antonio Totaro, Gabriella Sole, Angius, A, Spinelli, P, Ghilotti, G, Casu, G, Sole, G, Loi, A, Totaro, A, Zelante, L, Gasparini, Paolo, Orzalesi, N, Pirastu, M, and Bonomi, L.
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Male ,medicine.medical_specialty ,genetic structures ,Open angle glaucoma ,DNA Mutational Analysis ,Ocular hypertension ,Glaucoma ,Risk Factors ,Internal medicine ,Ophthalmology ,medicine ,Humans ,Missense mutation ,Age of Onset ,Eye Proteins ,Myocilin ,Aged ,Glycoproteins ,Aged, 80 and over ,business.industry ,Age Factors ,DNA ,Middle Aged ,medicine.disease ,Penetrance ,eye diseases ,Pedigree ,Cytoskeletal Proteins ,Mutation ,Mutation (genetic algorithm) ,Codon, Terminator ,Female ,Ocular Hypertension ,sense organs ,Age of onset ,DNA Probes ,business ,Glaucoma, Open-Angle - Abstract
Juvenile open-angle glaucoma has been found to be associated with molecular defects in the myocilin (MYOC) gene. Most of the defects are missense mutations located in the third exon. The Gln368stop mutation has recently been found in several cases of late-onset primary open-angle glaucoma (POAG).To study the effect of glaucoma risk in a relatively homogeneous genetic population.A clinical study was performed in all living members of a 5-generation family. DNA analysis was performed for studying association with genetic markers and identifying the mutation.We identified the Gln368stop molecular defect in 19 patients with POAG, 5 patients with ocular hypertension, and 22 healthy carriers. We compared affected and unaffected carriers based on age at onset and last examination, respectively. Besides the presence of 3 young patients with POAG (40 years old), the number of glaucomatous patients in the advanced age group increased.The penetrance of glaucoma increases with age in Gln368stop carriers, but some remain unaffected at advanced age and others are affected at an early age. This suggests that additional risk factors are operating within this family, which may be identified by a genome-wide linkage search in this large pedigree.The myocilin Gln368stop mutation shows a good genotype-phenotype correlation and should be investigated in all familiar cases of chronic POAG. This may be important for early diagnosis and periodical checkups of presymptomatic individuals belonging to these families.
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- 2000
26. Relationship between morphometric optic disc parameters, sex and axial length
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Luca Rossetti, Stefano Miglior, Cristiana Balestreri, Paola Velati, Nicola Orzalesi, E. Bujtar, L. Brigatti, Miglior, S, Brigatti, L, Velati, P, Balestreri, C, Rossetti, L, Bujtar, E, and Orzalesi, N
- Subjects
Adult ,Male ,Optic Disk ,Optic disk ,Glaucoma ,Optic cup (anatomical) ,Eye ,Cellular and Molecular Neuroscience ,Reference Values ,Image Processing, Computer-Assisted ,Medicine ,Humans ,Statistical analysis ,Reference Value ,Aged ,Sex Characteristics ,Anthropometry ,business.industry ,Axial length ,Anatomy ,Middle Aged ,medicine.disease ,Sensory Systems ,Ophthalmology ,medicine.anatomical_structure ,Female ,business ,Optical disc ,Optic disc ,Human - Abstract
Optic disc correlations were evaluated in normal eyes by means of computer-aided morphometry. Two hundred and thirty-five subjects (144 women and 91 men) entered the study. One eye per patient was randomly chosen for statistical analysis. Disc area (P < 0.05) and axial length (P < 0.0001) were statistically different between sexes. There was a correlation between axial length and both disc area (r for females = 0.55, P < 0.00001; r for males = 0.35, P < 0.0007) and refraction (r for females = 0.40, P < 0.00001; r for males = 0.50, P < 0.00001). The main findings of this investigation were that disc area is greater in male than in female eyes (thus clinically confirming the Ishi's and Quigley's previous observations of autopsy eyes) on the basis of axial length difference between the two sexes, and that disc size correlated with axial length. Disagreements in disc measurements reported in previous studies may be caused by differences in the male/female ratios of their samples.
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- 1994
27. Temporal corneal phacoemulsification combined with separate-incision superior trabeculectomy vs standard phacotrabeculectomy. A comparative study
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Stefano Miglior, Luigi Bucci, Luca Rossetti, Nicola Orzalesi, Rossetti, L, Bucci, L, Miglior, S, and Orzalesi, N
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Adult ,Male ,Intraocular pressure ,medicine.medical_specialty ,medicine.medical_treatment ,Visual Field ,Glaucoma ,Trabeculectomy ,Cataract ,Follow-Up Studie ,Cornea ,Postoperative Complications ,Ophthalmology ,medicine ,Humans ,In patient ,Intraocular Pressure ,Aged ,Aged, 80 and over ,Phacoemulsification ,business.industry ,Significant difference ,Middle Aged ,medicine.disease ,eye diseases ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Postoperative Complication ,sense organs ,Visual Fields ,Complication ,business ,Follow-Up Studies ,Human - Abstract
Summary The aim of the study was to compare functional and refractive outcome after temporal approach phacoemulsification combined with superior trabeculectomy against that of standard superior phacotrabeculectomy in patients affected by cataract and uncontrolled glaucoma. Fifty patients undergoing combined surgery were randomly allocated to receive either a standard superior phacotrabeculectomy (group A) or a temporal via clear cornea phacoemulsification combined with a separate superior trabeculectomy (group B). Short-term and long-term mean IOP reductions were similar in the two groups though, at 2 years, more patients in the standard phacotrabeculectomy group had need of medical therapy to control their ocular pressure (p=0.04). Group B had less surgically induced astigmatism than group A (p=0.05). There was no significant difference in ocular inflammation and complication rates between the 2 groups.
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- 2009
28. Technical procedures and software for magnification-corrected morphometry of optic disk photography
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Stefano Miglior, L. Brigatti, Ferdinando Bottoni, Nicola Orzalesi, Brigatti, L, Bottoni, F, Miglior, S, and Orzalesi, N
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genetic structures ,Computer science ,Optic Disk ,Optic disk ,Magnification ,Glaucoma ,Software ,Optics ,medicine ,Image Processing, Computer-Assisted ,Photography ,Vision Test ,Humans ,Computer vision ,Vision test ,business.industry ,Vision Tests ,General Medicine ,medicine.disease ,eye diseases ,Sensory Systems ,Ophthalmology ,Personal computer ,sense organs ,Artificial intelligence ,business ,Optical disc ,Graphics tablet ,Human - Abstract
In order to obtain a new diagnostic tool for the early diagnosis of glaucoma, we developed a method based on computerized analysis of the optic disk, cup and neuroretinal rim areas. A fundus camera, a personal computer and a graphic tablet are employed. Suitable software was developed for calculating the areas (disk, cup and rim) providing an index, the rim/disk ratio. The method revealed high repeatability and reproducibility. The simplicity and speed of the procedure make this test suitable for routine clinical use in the early diagnosis of glaucoma.
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- 1991
29. Correlation between the progression of optic disc and visual field changes in glaucoma
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Luca Rossetti, C.O. Pierrottet, Nicola Orzalesi, Stefano Miglior, L. Brigatti, C. Lonati, Miglior, S, Brigatti, L, Lonati, C, Rossetti, L, Pierrottet, C, and Orzalesi, N
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Male ,medicine.medical_specialty ,genetic structures ,Optic Disk ,Optic disk ,Glaucoma ,Ocular hypertension ,Correlation ,Cellular and Molecular Neuroscience ,Ophthalmology ,medicine ,Humans ,skin and connective tissue diseases ,Aged ,medicine.diagnostic_test ,business.industry ,Temporal correlation ,Middle Aged ,medicine.disease ,eye diseases ,Sensory Systems ,Visual field ,medicine.anatomical_structure ,Visual field test ,Disease Progression ,Female ,Ocular Hypertension ,sense organs ,Visual Fields ,business ,Glaucoma, Open-Angle ,Optic disc ,Human - Abstract
Visual field test and optic disc evaluation are the standard examination techniques used to detect the onset and progression of glaucoma. This explorative study was performed to assess the temporal correlation between visual field and optic disc changes in eyes with ocular hypertension and well-established glaucoma. Eighty-six hypertensive and 16 glaucomatous eyes were followed up for a period of up to 9 years (average 4.4 yrs) using kinetic and computerized static perimetry and optic disc manual morphometry. Perimetric changes were based on a series of strict criteria and optic disc changes were based as a reduction in the baseline rim area/disc area ratio (R/D) measurement exceeding the 99% confidence interval for intraobserver reproducibility (7.7%). Optic disc changes were found prior to visual field changes in four hypertensive eyes, whereas visual field changes were found prior to disc changes in six glaucomatous eyes (p = 0.042). The results of our explorative study suggest that quantitative optic disc analysis may be more sensitive than visual field examination in detecting early glaucomatous changes, whereas visual field examination may be more sensitive than quantitative optic disc analysis in detecting glaucomatous progressions in eyes with well established glaucoma.
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