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Yibin area is located in the southwestern margin of Sichuan Basin of upper Yangtze River basin, close to the southeastern boundary of the Qinghai-Tibetan Plateau. The paleoclimatic characteristics recorded by Quaternary river sediments in this area can display the impact of uplift of the Qinghai-Tibetan Plateau on paleoclimate change of Sichuan Basin. In this paper, the macro-characteristics, clay minerals and the diagnosis geochemical elements characteristics of the sediments of terraces and floodplain were used as climatic proxies to explore the evolutionary process of the Quaternary paleoclimatic change in the study area. Key findings can be shown as follows: 1) warm and humid paleoclimate occurred during the Middle Pleistocene and the early Late Pleistocene (730–90 ka), shown by the high values of Al 2 O 3 , Fe 2 O 3 , Rb/Sr, chemical index of alteration (CIA, 82–97), illite chemical index (ICI, >0.5), kaolinite and the low values of Na 2 O, K 2 O, MgO, K 2 O/Al 2 O 3 , (CaO + Na 2 O)/Al 2 O 3 , illite, smectite, chlorite from the brown or brownish-red sediments of the terraces T5 to T3. 2) The reversal values of these geochemical and clay mineral proxies (e.g., values of CIA between 50 and 64) derived from grey and greyish-yellow sediments in terrace T2 and floodplain denote the dry and cold paleoclimate, emerging in the middle-late Late Pleistocene (50 ka), corresponding to the Baiyu glacial period of the Qinghai-Tibetan Plateau. Comparing the paleoclimatic evolutionary characteristics in Yibin area with those of the Three Gorges area of northeastern margin of Sichuan Basin from previous researches, this paper considers that during the Gonghe tectonic movement (0.15 Ma), the uplift of the Qinghai-Tibetan Plateau and its southeastern boundary intensified the Plateau winter monsoon and caused the southwesterly withdrawal of the Indian monsoon from Sichuan Basin. Consequently, the warm and humid paleoclimate at the northeastern and southwestern margins of the Basin had successively become dry and cold in the early and middle-late periods of the Late Pleistocene. • Paleoclimate information can be well preserved in terrace sediments in Yibin area. • The paleoclimate in Yibin area had changed from warm and wet to cold and dry since 50 ka. • Quaternary paleoclimate changed to dry and cold from northeast to southwest in the Sichuan Basin. • Tibetan Plateau's Gonghe tectonic movement enhanced the Plateau monsoon and blocked the Indian summer monsoon. • Influence of Indian summer monsoon weakened in the Sichuan Basin along the SW direction after 110 ka. [ABSTRACT FROM AUTHOR]