1. Necrotizing ulcerative periodontitis associated with severe congenital immunodeficiency in a prepubescent subject: clinical findings and response to intravenous immunoglobulin treatment.
- Author
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Batista EL Jr, Novaes AB Jr, Calvano LM, do Prado EA, Goudouris ES, and Batista FC
- Subjects
- Child, Common Variable Immunodeficiency blood, Common Variable Immunodeficiency therapy, Follow-Up Studies, Gingivitis, Necrotizing Ulcerative blood, Gingivitis, Necrotizing Ulcerative etiology, Humans, Immunoglobulin Isotypes blood, Immunoglobulins, Intravenous administration & dosage, Infusions, Intravenous, Male, Periodontitis blood, Periodontitis therapy, Common Variable Immunodeficiency complications, Gingivitis, Necrotizing Ulcerative immunology, Gingivitis, Necrotizing Ulcerative therapy, Immunoglobulins, Intravenous therapeutic use, Periodontitis immunology
- Abstract
Common variable immunodeficiency (CVID) is a rare multifactorial congenital disease of genetic origin caused by an impairment in the secretion of specific immunoglobulins. It manifests systemically through recurrent respiratory infections, gastrointestinal disorders and autoimmune diseases. Oral manifestations may include gingivitis and lichenoid lesions with Wickham's striae. The treatment for CVID is supported by using intravenous infusion of immunoglobulins (IVIG) that allows for control of the disease and avoidance of recurrent opportunistic infections. This report presents a case of necrotizing ulcerative periodontitis (NUP) in a young patient with CVID, and correlates his periodontal status with systemic conditions before and after IVIG administration during 1 year of evaluation.
- Published
- 1999
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