9 results on '"Galjaard, Sander"'
Search Results
2. Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes:A Randomized Controlled Trial Post Hoc Analysis
- Author
-
Simmons, David, Devlieger, Roland, van Assche, Andre, Galjaard, Sander, Corcoy, Rosa, Adelantado, Juan M., Dunne, Fidelma, Desoye, Gernot, Abenhaim, Alexandra, Afifi, Jehier, Alvaro, Ruben, Andrews, James, Armson, Anthony, Audibert, Francois, Aziz, Khalid, Ballantyne, Marilyn, Barrett, Jon, Beltempo, Marc, Berard, Anick, Bertelle, Valerie, Blais, Lucie, Bocking, Alan, Bodani, Jaya, Burrows, Jason, Butt, Kimberly, Canning, Roderick, Obstetrics & Gynecology, Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Public and occupational health, and Amsterdam Reproduction & Development (AR&D)
- Subjects
Lifestyle intervention ,endocrine system diseases ,physical activity ,Overweight ,motivational interviewing ,Weight Gain ,Gestational diabetes mellitus ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,prevention ,law ,Pregnancy ,030212 general & internal medicine ,2. Zero hunger ,Randomised controlled trial ,Nutrition and Dietetics ,Obstetrics ,Motivational interviewing ,Diabetes ,Healthy eating ,Physical activity ,Prevention ,Adult ,Diabetes, Gestational ,Female ,Humans ,Life Style ,Pregnancy Complications ,female genital diseases and pregnancy complications ,gestational diabetes mellitus ,3. Good health ,healthy eating ,Gestational diabetes ,Gestational ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,medicine.medical_specialty ,Diabetes, Gestational/pathology ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Article ,03 medical and health sciences ,Insulin resistance ,SDG 3 - Good Health and Well-being ,Post-hoc analysis ,medicine ,overweight ,business.industry ,nutritional and metabolic diseases ,lifestyle intervention ,medicine.disease ,Pregnancy Complications/prevention & control ,business ,Body mass index ,Weight gain ,randomised controlled trial ,Food Science - Abstract
Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women with a body mass index (BMI) &ge, 29 kg/m2 <, 20 weeks gestation without GDM (n = 436) were randomized, in a multicenter trial, to usual care (UC), healthy eating (HE), physical activity (PA), or HE and PA lifestyle interventions. GWG over the median was associated with higher homeostasis model assessment insulin resistance (HOMA-IR) and insulin secretion (Stumvoll phases 1 and 2), a higher fasting plasma glucose (FPG) at 24&ndash, 28 weeks (4.66 ±, 0.43 vs. 4.61 ±, 0.40 mmol/L, p <, 0.01), and a higher rate of caesarean section (38% vs. 27% p <, 0.05). The GWG over the median at 35&ndash, 37 weeks was associated with a higher rate of macrosomia (25% vs. 16%, p <, 0.05). A post hoc comparison among women from the five sites with a GWG difference >, 3 kg showed no significance difference in glycaemia or insulin resistance between HE and PA, and UC. We conclude that preventing even substantial increases in GWG after the first trimester has little effect on maternal glycaemia. We recommend randomized controlled trials of effective lifestyle interventions, starting in or before the first trimester.
- Published
- 2018
3. Temporal relationships between maternal metabolic parameters with neonatal adiposity in women with obesity differ by neonatal sex: Secondary analysis of the DALI study.
- Author
-
Lima, Rodrigo A., Desoye, Gernot, Simmons, David, Devlieger, Roland, Galjaard, Sander, Corcoy, Rosa, Adelantado, Juan M., Dunne, Fidelma, Harreiter, Jürgen, Kautzky‐Willer, Alexandra, Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise‐Lotte, Tanvig, Mette, Lapolla, Annunziata, Dalfra, Maria G., Bertolotto, Alessandra, Wender‐Ozegowska, Ewa, and Zawiejska, Agnieszka
- Subjects
BLOOD sugar analysis ,RISK of childhood obesity ,ADIPOSE tissues ,GESTATIONAL diabetes ,FATTY acids ,GESTATIONAL age ,INSULIN resistance ,LONGITUDINAL method ,PREGNANT women ,WEIGHT gain in pregnancy ,RISK assessment ,SEX distribution ,SKINFOLD thickness ,TRIGLYCERIDES ,VITAMIN D ,LEPTIN ,SECONDARY analysis ,BODY mass index ,LIFESTYLES ,CHILDREN ,PREGNANCY - Abstract
Summary: Objectives: To investigate the importance of time in pregnancy and neonatal sex on the association between maternal metabolic parameters and neonatal sum of skinfolds. Methods: This was a longitudinal, secondary analysis of the vitamin D and lifestyle intervention for gestational diabetes mellitus study, conducted in nine European countries during 2012 to 2015. Pregnant women with a pre‐pregnancy body mass index (BMI) of ≥29 kg/m2 were invited to participate. We measured 14 maternal metabolic parameters at three times during pregnancy: <20 weeks, 24 to 28 weeks, and 35 to 37 weeks of gestation. The sum of four skinfolds assessed within 2 days after birth was the measure of neonatal adiposity. Results: In total, 458 mother‐infant pairs (50.2% female infants) were included. Insulin resistance (fasting insulin and HOMA‐index of insulin resistance) in early pregnancy was an important predictor for boys' sum of skinfolds, in addition to fasting glucose and maternal adiposity (leptin, BMI and neck circumference) throughout pregnancy. In girls, maternal lipids (triglycerides and fatty acids) in the first half of pregnancy were important predictors of sum of skinfolds, as well as fasting glucose in the second half of pregnancy. Conclusions: Associations between maternal metabolic parameters and neonatal adiposity vary between different periods during pregnancy. This time‐dependency is different between sexes, suggesting different growth strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Risk factors for hyperglycemia in pregnancy in the DALI study differ by period of pregnancy and OGTT time point.
- Author
-
Mendoza, Lilian C., Harreiter, Jürgen, Simmons, David, Desoye, Gernot, Adelantado, J. M., Juarez, Fabiola, Chico, Ana, Devlieger, Roland, van Assche, Andre, Galjaard, Sander, Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise Lotte T., Tanvig, Mette, Lapolla, Annunziata, Dalfra, Maria G., Bertolotto, Alessandra, Mantaj, Urszula, and Wender-Ozegowska, Ewa
- Subjects
HYPERGLYCEMIA ,GESTATIONAL diabetes ,DISEASE risk factors - Abstract
Objective: Risk factors are widely used to identify women at risk for gestational diabetes mellitus (GDM) without clear distinction by pregnancy period or oral glucose tolerance test (OGTT) time points. We aimed to assess the clinical risk factors for Hyperglycemia in pregnancy (HiP) differentiating by these two aspects. Design and methods: Nine hundred seventy-one overweight/obese pregnant women, enrolled in the DALI study for preventing GDM. OGTTs were performed at =19 + 6, 24-28 and 35-37 weeks (IADPSG/WHO2013 criteria). Women with GDM or overt diabetes at one time point did not proceed to further OGTTs. Potential independent variables included baseline maternal and current pregnancy characteristics. Statistical analysis: Multivariate logistic regression. Results: Clinical characteristics independently associated with GDM/overt diabetes were at =19 + 6 weeks, previous abnormal glucose tolerance (odds ratio (OR): 3.11; 95% CI: 1.41-6.85), previous GDM (OR: 2.22; 95% CI: 1.20-4.11), neck circumference (NC) (OR: 1.58; 95% CI: 1.06-2.36 for the upper tertile), resting heart rate (RHR, OR: 1.99; 95% CI: 1.31-3.00 for the upper tertile) and recruitment site; at 24-28 weeks, previous stillbirth (OR: 2.92; 95% CI: 1.18-7.22), RHR (OR: 3.32; 95% CI: 1.70-6.49 for the upper tertile) and recruitment site; at 35-37 weeks, maternal height (OR: 0.41; 95% CI: 0.20-0.87 for upper tertile). Clinical characteristics independently associated with GDM/overt diabetes differed by OGTT time point (e.g. at =19 + 6 weeks, NC was associated with abnormal fasting but not postchallenge glucose). Conclusion: In this population, most clinical characteristics associated with GDM/overt diabetes were non-modifiable and differed by pregnancy period and OGTT time point. The identified risk factors can help define the target population for future intervention trials. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
5. Is a motivational interviewing based lifestyle intervention for obese pregnant women across Europe implemented as planned? Process evaluation of the DALI study.
- Author
-
Jelsma, Judith G. M., Simmons, David, Gobat, Nina, Rollnick, Stephen, Blumska, Kinga, Jans, Goele, Galjaard, Sander, Desoye, Gernot, Corcoy, Rosa, Juarez, Fabiola, Kautzky-Willer, Alexandra, Harreiter, Jürgen, van Assche, Andre, Devlieger, Roland, Timmerman, Dirk, Hill, David, Damm, Peter, Mathiesen, Elisabeth R., Wender-Ożegowska, Ewa, and Zawiejska, Agnieszka
- Subjects
WEIGHT gain in pregnancy ,OBESITY in women ,GESTATIONAL diabetes ,EXERCISE for pregnant women ,PREGNANCY complications ,OBESITY treatment ,OBESITY complications ,DIET ,EXERCISE ,EVALUATION of medical care ,PATIENT satisfaction ,WEIGHT gain ,MOTIVATIONAL interviewing ,PREVENTION - Abstract
Background: Process evaluation is an essential part of designing and assessing complex interventions. The vitamin D and lifestyle intervention study (DALI) study is testing different strategies to prevent development of gestational diabetes mellitus among European obese pregnant women with a body mass index ≥29 kg/m2. The intervention includes guidance on physical activity and/or healthy eating by a lifestyle coach trained in motivational interviewing (MI). The aim of this study was to assess the process elements: reach, dose delivered, fidelity and satisfaction and to investigate whether these process elements were associated with changes in gestational weight gain (GWG).Methods: Data on reach, dose delivered, fidelity, and satisfaction among 144 participants were collected. Weekly recruitment reports, notes from meetings, coach logs and evaluation questionnaires (n = 110) were consulted. Fidelity of eight (out of twelve) lifestyle coach practitioners was assessed by analysing audio recorded counselling sessions using the MI treatment integrity scale. Furthermore, associations between process elements and GWG were assessed with linear regression analyses.Results: A total of 20% of the possible study population (reach) was included in this analysis. On average 4.0 (of the intended 5) face-to-face sessions were delivered. Mean MI fidelity almost reached 'expert opinion' threshold for the global scores, but was below 'beginning proficiency' for the behavioural counts. High variability in quality of MI between practitioners was identified. Participants were highly satisfied with the intervention, the lifestyle coach and the intervention materials. No significant associations were found between process elements and GWG.Conclusion: Overall, the intervention was well delivered and received by the study population, but did not comply with all the principles of MI. Ensuring audio recording of lifestyle sessions throughout the study would facilitate provision of individualized feedback to improve MI skills. A larger sample size is needed to confirm the lack of association between process elements and GWG.Trial Registration: ISRCTN registry: ISRCTN70595832 ; Registered 12 December 2011. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
6. Results From a European Multicenter Randomized Trial of Physical Activity and/or Healthy Eating to Reduce the Risk of Gestational Diabetes Mellitus: The DALI Lifestyle Pilot.
- Author
-
Simmons, David, Jelsma, Judith G. M., Galjaard, Sander, Devlieger, Roland, van Assche, Andre, Jans, Goele, Corcoy, Rosa, Adelantado, Juan M., Dunne, Fidelma, Desoye, Gernot, Harreiter, Jürgen, Kautzky-Willer, Alexandra, Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise Lotte, Lapolla, Annunziata, Dalfra, Maria, Bertolotto, Alessandra, and Wender-Ozegowska, Ewa
- Subjects
GESTATIONAL diabetes ,PHYSICAL activity ,NUTRITION ,BLOOD sugar ,INSULIN resistance ,WEIGHT gain ,HEALTH outcome assessment ,THERAPEUTICS - Abstract
OBJECTIVE Ways to prevent gestational diabetes mellitus (GDM) remain unproven. We compared the impact of three lifestyle interventions (healthy eating [HE], physical activity [PA], and both HE and PA [HE+PA]) on GDM risk in a pilot multicenter randomized trial. RESEARCH DESIGN AND METHODS Pregnant women at risk for GDM (BMI ≥29 kg/m²) from nine European countries were invited to undertake a 75-g oral glucose tolerance test before 20 weeks' gestation. Those without GDM were randomized to HE, PA, or HE+PA. Women received five face-to-face and four optional telephone coaching sessions, based on the principles of motivational interviewing. A gestational weight gain (GWG) <5 kg was targeted. Coaches received standardized training and an intervention toolkit. Primary outcome measures were GWG, fasting glucose, and insulin sensitivity (HOMA) at 35-37 weeks. RESULTS Among the 150 trial participants, 32% developed GDM by 35-37 weeks and 20% achieved GWG <5 kg. HE women had less GWG (-2.6 kg [95% CI -4.9, -0.2]; P = 0.03) and lower fasting glucose (-0.3mmol/L [-0.4,-0.1]; P = 0.01) than those in the PA group at 24-28 weeks. HOMA was comparable. No significant differences between HE+PA and the other groups were observed. CONCLUSIONS An antenatal HE intervention is associated with less GWG and lower fasting glucose comparedwith PA alone. These findings require a larger trial for confirmation but support the use of early HE interventions in obese pregnant women. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
7. IADPSG and WHO 2013 Gestational Diabetes Mellitus Criteria Identify Obese Women With Marked Insulin Resistance in Early Pregnancy.
- Author
-
Harreiter, Jürgen, Simmons, David, Desoye, Gernot, Corcoy, Rosa, Adelantado, Juan M., Devlieger, Roland, van Assche, Andre, Galjaard, Sander, Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise Lotte T., Dunne, Fidelma, Lapolla, Annunziata, Dalfra, Maria G., Bertolotto, Alessandra, Mantaj, Urzula, Wender-Ozegowska, Ewa, Zawiejska, Agnieszka, and Hill, David
- Subjects
INSULIN resistance ,DIABETES complications ,DRUG resistance ,INSULIN antibodies ,GESTATIONAL diabetes ,TREATMENT of diabetes ,TREATMENT of pregnancy complications ,DIAGNOSIS - Abstract
The article focuses on the determination of obese women having marked insulin resistance in early pregnancy through the gestational diabetes mellitus (GDM) recommendations of the 2013 World Health Organization and the International Association of Diabetes and Pregnancy Study Groups (IADPSG). Topics discussed include an overview of GDM, its diagnosis, its prevalence, and its treatment.
- Published
- 2016
- Full Text
- View/download PDF
8. Re: Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect.
- Author
-
Corcoy, Rosa, Mendoza, Lilian C., Simmons, David, Desoye, Gernot, Mathiesen, Elisabeth R., Kautzky‐Willer, Alexandra, Damm, Peter, Dunne, Fidelma P., Wender‐Ozegowska, Ewa, Lapolla, Annunziata, van Assche, Andre, Devlieger, Roland, Hill, David, Jensen, Dorte M., Adelantado, Juan M., Zawiejska, Agnieszka, Bertolotto, Alessandra, Dalfra, Maria G., Harreiter, Jürgen, and Galjaard, Sander
- Subjects
GESTATIONAL diabetes ,HAWTHORNE effect ,VITAMIN D ,VITAMIN D deficiency ,VITAMINS - Published
- 2018
- Full Text
- View/download PDF
9. Mediators of Lifestyle Behaviour Changes in Obese Pregnant Women. Secondary Analyses from the DALI Lifestyle Randomised Controlled Trial.
- Author
-
van Poppel, Mireille N. M., Jelsma, Judith G. M., Simmons, David, Devlieger, Roland, Jans, Goele, Galjaard, Sander, Corcoy, Rosa, Adelantado, Juan M., Dunne, Fidelma, Harreiter, Jürgen, Kautzky-Willer, Alexandra, Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise-Lotte, Tanvig, Mette, Lapolla, Annunziata, Dalfra, Maria-Grazia, Bertolotto, Allessandra, and Wender-Ozegowska, Ewa
- Abstract
A better understanding of what drives behaviour change in obese pregnant overweight women is needed to improve the effectiveness of lifestyle interventions in this group at risk for gestational diabetes (GDM). Therefore, we assessed which factors mediated behaviour change in the Vitamin D and Lifestyle Intervention for GDM Prevention (DALI) Lifestyle Study. A total of 436 women, with pre-pregnancy body mass index ≥29 kg/m
2 , ≤19 + 6 weeks of gestation and without GDM, were randomised for counselling based on motivational interviewing (MI) on healthy eating and physical activity, healthy eating alone, physical activity alone, or to a usual care group. Lifestyle was measured at baseline, and at 24–28 and 35–37 weeks of gestation. Outcome expectancy, risk perception, task self-efficacy and social support were measured at those same time points and considered as possible mediators of intervention effects on lifestyle. All three interventions resulted in increased positive outcome expectancy for GDM reduction, perceived risk to the baby and increased task self-efficacy. The latter mediated intervention effects on physical activity and reduced sugared drink consumption. In conclusion, our MI intervention was successful in increasing task self-efficacy, which was related to improved health behaviours. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.