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Start Over Descriptor "GCT, glucose challenge test" Topic gestational diabetes
3 results on '"GCT, glucose challenge test"'

1. Subtypes of gestational diabetes and future risk of pre-diabetes or diabetes

Author

Ravi Retnakaran, Bernard Zinman, Anthony J. Hanley, Chang Ye, Mathew Sermer, and Philip W. Connelly

Subjects
medicine.medical_specialty, endocrine system diseases, Future risk, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, postpartum, Oral glucose tolerance, HOMA-IR, Homeostasis Model Assessment of insulin resistance, Prospective cohort study, 030304 developmental biology, 0303 health sciences, Pregnancy, Metabolic function, business.industry, Obstetrics, beta-cell function, GDM, gestational diabetes mellitus, subtypes, GCT, glucose challenge test, IGI/HOMA-IR, insulinogenic index divided by HOMA-IR, nutritional and metabolic diseases, General Medicine, medicine.disease, OGTT, oral glucose challenge test, female genital diseases and pregnancy complications, 3. Good health, Gestational diabetes, Pre diabetes, gestational diabetes, heterogeneity, business, Research Paper, ISSI-2, Insulin Secretion-Sensitivity Index-2
Abstract

Background Recent studies have suggested that gestational diabetes (GDM) is a heterogeneous condition with distinct subtypes determined by whether the predominant metabolic abnormality is impaired insulin sensitivity or deficient insulin secretion. However, it is not known if the elevated future risk of pre-diabetes/diabetes associated with GDM varies according to these subtypes. Thus, we sought to evaluate maternal metabolic function in the 1st year postpartum in relation to GDM subtypes. Methods In this prospective cohort study conducted in Toronto, Canada, 613 women underwent GDM screening by oral glucose tolerance test (OGTT) in pregnancy, followed by repeat OGTT at both 3-months and 12-months postpartum between 09/2003 and 03/2016. The antepartum OGTT identified 3 groups of women: GDM with predominant sensitivity defect (GDM-sensitivity), GDM with predominant secretion defect (GDM-secretion), and non-GDM. Findings Antepartum findings persisted after pregnancy, with lower insulin sensitivity in GDM-sensitivity (Matsuda index; HOMA-IR) and lower insulin secretion in GDM-secretion (Stumvoll first-phase; insulinogenic index (IGI)) at both 3-months and 12-months (all p

Published
2021

3. Adolescent body mass index and changes in pre-pregnancy body mass index in relation to risk of gestational diabetes

Author

Maayan Omer-Gilon, Orit Pinhas-Hamiel, Estela Derazne, Dorit Tzur, Gilad Twig, Amir Tirosh, Varda Shalev, Inbar Zucker, Ran S Rotem, Gal Puris, Arnon Afek, Avi Shina, Gabriel Chodick, and Tali Cukierman-Yaffe

Subjects
Medicine (General), medicine.medical_specialty, GAM, generalized additive model, GDM, Adolescent, BMI, body mass index, Population, Overweight, BMI, R5-920, medicine, education, Original Research, education.field_of_study, Pregnancy, diabetes, GDM, gestational diabetes mellitus, business.industry, Obstetrics, GCT, glucose challenge test, SES, socioeconomic status, nutritional and metabolic diseases, General Medicine, medicine.disease, Obesity, OR, odds ratio, Gestational diabetes, CI, confidence intervals, MHS, Maccabi Healthcare Services, pregnancy, women, Underweight, medicine.symptom, gestational, SD, standard deviation, business, Body mass index, Adolescent health
Abstract

Background: Pregestational excessive body mass index (BMI) is linked to an increased risk for gestational diabetes mellitus (GDM), but less is known on the effect of adolescent BMI on GDM occurrence. The study aimed to investigate possible associations of adolescent BMI and changes in BMI experienced before first pregnancy, with gestational diabetes risk. Methods: This retrospective study was based on linkage of a military screening database of adolescent health status (Israel Defence Forces) including measured height and weight, with medical records (Maccabi Healthcare Services, MHS) of a state-mandated health provider. The latter covers about 25% of the Israeli population; about 90% of pregnant women undergo screening by the two-step Carpenter-Coustan method. Adolescent BMI was categorized according to Center of Disease Control and Prevention percentiles. Only first documented pregnanies were analyzed and GDM was the outcome. Findings: Of 190,905 nulliparous women, 10,265 (5.4%) developed GDM. Incidence proportions of GDM were 5.1%, 6.1%, 7.3%, and 8.9% among women with adolescent normal BMI, underweight, overweight, and obesity (p

Published
2021
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