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Due to the changes of estrogen and progesterone level during pregnancy, the endocrine metabolism will undergo corresponding physiological changes during pregnancy. But when the changes exceed the physiological upper limit, it will cause a series of pregnancy complications, such as gestational diabetes mellitus (GDM), hypertensive disorder complicating pregnancy, premature rupture of membranes, preterm delivery and giant babies. GDM is one of the more common complications, and as an endocrine disease, GDM is often associated with abnormalities in glucose and lipid metabolism. However, abnormalities in lipid metabolism can also increase the risk of developing GDM. The detection and control of dyslipidemia in early pregnancy is of great significance for the prevention, confirmation and treatment of GDM, and therefore the study of lipid metabolism in GDM is of great interest. There are no clear findings on whether alterations in lipid metabolism increase the risk of developing GDM or whether the onset of GDM leads to disturbances in lipid metabolism. This paper will review the progress of research on normal lipid metabolism in pregnancy and the relationship between lipid metabolism and GDM in pregnancy. [ABSTRACT FROM AUTHOR]

Gestational diabetes mellitus (GDM) is one of the major complications during pregnancy. With the implementation of the two -child policy, the improvement of living standard and the change of marriage concept, the incidence of GDM has been increasing year by year under the influence of high risk factors such as obesity, age and genetic susceptibility. At present, the specific pathogenesis of GDM is not clear, which may be related to insulin resistance and dysfunction of insulin β cell. The disorder of glucose metabolism in pregnant women with GDM will further lead to the disorder of lipid metabolism, leading to adverse pregnant outcomes. Adipokines, such as betatrophin, chemerin, C1q/tumor necrosis factor related protein (CTRP9) and leptin, may play a role in the pathogenesis of GDM. This article reviews the roles of adipokines in the regulation of glucose and lipid metabolism, and the pathogenesis of GDM. [ABSTRACT FROM AUTHOR]