29 results on '"Federica Ribaldi"'
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2. Relationship between [18F]flortaucipir PET visual patterns and neurodegeneration
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Fiona Heeman, Alexis Moscoso, Valle Camacho, Martijn van Essen, Michel J. Grothe, Li Lin, Isminni Mainta, Federica Ribaldi, Michael D. Devous, Michael J. Pontecorvo, Giovanni B Frisoni, Valentina Garibotto, Michael Schöll, and Radiology and nuclear medicine
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Abstract
Background: The introduction of tau positron emission tomography (PET) ligands has allowed for the in vivo assessment of tau pathology in Alzheimer’s disease (AD). The recent development and FDA approval of [18F]flortaucipir (FTP) reader guidelines has enabled standardized visual assessment of FTP PET scans as showing negative, moderate or advanced AD tau patterns, thereby facilitating implementation of FTP scans in clinical practice. Although various studies have reported associations between regional FTP signal and neurodegeneration, the relationship between the standardized visual FTP AD patterns and markers of neurodegeneration has not yet been studied. This study aims to understand how FTP AD visual patterns relate to markers of neurodegeneration from structural MRI and FDG-PET scans. Specifically, it focusses on characterizing regional neurodegeneration associated with the moderate AD pattern, both in cognitively normal (CN) and cognitively impaired participants (CI). Method: Participants from five cohorts were included: the Alzheimer’s Disease Neuroimaging Initiative, Harvard Aging Brain Study, A4 study, the Geneva Memory Clinic cohort and AVID’s A05 study. These cohorts include CN participants, mild cognitively impaired and AD dementia patients who have available FTP, MRI and/or FDG scans, a subset also received follow-up MRI scans. Furthermore, Centiloid values are available for all participants to quantitatively determine amyloid-β (Aβ) positivity. All FTP scans are currently independently evaluated by three trained readers, blinded to clinical and imaging information. Majority read is used to assign scans to the negative, moderate or advanced AD tau pattern groups. Result: A total of 1948 participants underwent baseline FTP PET and MRI scans, a subset of 462 participants also underwent FDG-PET scans. Between-group differences in MRI- and FDG-derived patterns of neurodegeneration are evaluated cross-sectionally. In addition, the value of FTP AD patterns for predicting longitudinal neurodegeneration using MRI-derived atrophy measures is assessed using Linear Mixed Models. All analyses are conducted separately for CN and CI participants, as well as stratified by Aβ (positive vs. negative) status. NB. Results of these analyses will be presented during the conference. Conclusion: This study will contribute to our understanding of the clinical relevance and prognostic value of the moderate and advanced FTP AD patterns in CN and CI individuals.
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- 2022
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3. Three‐Objects‐Three‐Places Test: Association with Alzheimer’s Disease Biomarkers
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Sophie Krug, Federica Ribaldi, Daniele Altomare, Valentina Garibotto, Szymon Tomczyk, Max Scheffler, Karl‐Olof Lovblad, Aldara Vazquez Fernandez, Christian Chicherio, and Giovanni B Frisoni
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
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4. Resistance, brain and cognitive resilience to ATN in a memory clinic population
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Federica Ribaldi, Lara Quattrocchi, Valentina Garibotto, Szymon Tomczyk, Max Scheffler, Karl‐Olof Lovblad, Aldara Vazquez Fernandez, Christian Chicherio, Kaj Blennow, Giovanni B Frisoni, and Daniele Altomare
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
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5. Prevalence and longitudinal clinical outcomes of negative, moderate, and advanced [ 18 F]flortaucipir PET visual patterns across the Alzheimer's disease spectrum
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Alexis Moscoso, Fiona Heeman, Valle Camacho, Martijn van Essen, Michel J. Grothe, Li Lin, Isminni Mainta, Federica Ribaldi, Michael D. Devous, Michael J. Pontecorvo, Giovanni B Frisoni, Valentina Garibotto, and Michael Schöll
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2022
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6. Prevalence and longitudinal clinical outcomes of negative, moderate, and advanced 18F-flortaucipir PET visual patterns in aging and Alzheimer’s disease
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Alexis Moscoso, Fiona Heeman, Valle Camacho, Martijn van Essen, Michel J. Grothe, Li Lin, Isminni Mainta, Federica Ribaldi, Michael D. Devous, Michael J. Pontecorvo, Giovanni B Frisoni, Valentina Garibotto, Michael Schöll, and Radiology and nuclear medicine
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Abstract
Background: The advent of positron emission tomography (PET) imaging with tracers such as [18F]flortaucipir (FTP) has allowed in-vivo visualization of aggregated tau in Alzheimer’s disease (AD). Recently, a clinically applicable visual interpretation method for FTP PET yielding negative, moderate, and advanced AD visual patterns was developed, leading to its subsequent approval by the US Food and Drug Administration (FDA). Yet, the prevalence and longitudinal clinical outcomes of the different AD-associated visual patterns, in particular the moderate AD pattern, have not been investigated systematically across the clinical spectrum of AD. Method: We included cognitively normal individuals and patients with mild cognitive impairment and AD dementia from five observational cohort studies — Alzheimer’s Disease Neuroimaging Initiative (ADNI), Harvard Aging Brain study (HABS), A4 study, AVID’s A05 study and Geneva Memory Clinic cohort — all of which had available FTP PET scans. Furthermore, Aβ status, established with Aβ PET, was available in 1924 participants (98%), and longitudinal clinical and cognitive data was obtained for 968 participants over an average follow-up time of 2.2 years. Three readers, blinded to clinical and imaging information, will independently evaluate each FTP PET scan, and an individual’s FTP uptake pattern will be interpreted as negative, moderate, or advanced AD tau pattern, based on the majority read of the three readers. Multinomial generalized additive models (GAM) will be fitted to provide prevalence estimates of each FTP AD pattern. Mixed models for repeated measures (MMRM) will be used to estimate cognitive decline trajectories. Result: A total of 1963 participants had available FTP PET scans. We will investigate the prevalence of the different FTP AD patterns as a function of age per diagnostic group, stratifying participants by β-amyloid status and APOE genotype. Further, in the subset of participants with available longitudinal clinical data, we will explore how the different FTP patterns associate with clinical decline across the aforementioned diagnostic groups. Conclusion: Our large-scale study will contribute significantly to elucidating the clinical relevance of FTP visual reads across the AD spectrum, potentially widening its applicability and promoting its use in patient assessment and in clinical prevention trials.
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- 2022
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7. The Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging
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Giulia Bommarito, Valentina Garibotto, Giovanni B. Frisoni, Federica Ribaldi, Sara Stampacchia, Frédéric Assal, Stéphane Armand, Gilles Allali, and Alessandra Griffa
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disease ,Amyloid ,white-matter ,General Neuroscience ,gait disorder ,vascular dementia ,Pilot Projects ,General Medicine ,Syndrome ,Magnetic Resonance Imaging ,White Matter ,diffusion mri ,Psychiatry and Mental health ,Clinical Psychology ,Cognition ,Cross-Sectional Studies ,Alzheimer Disease ,Positron-Emission Tomography ,alzheimer's disease ,Humans ,Cognitive Dysfunction ,Geriatrics and Gerontology ,slow gait ,hormones, hormone substitutes, and hormone antagonists ,lateral ventricles - Abstract
We conducted a cross-sectional pilot study to explore the biological substrate of the Motoric Cognitive Risk (MCR) syndrome in a Memory Clinic cohort, using a multimodal imaging approach. Twenty participants were recruited and classified as MCR+/−. Amyloid- and tau-PET uptakes, temporal atrophy, white matter hyperintensities, lateral ventricular volume (LVV), and diffusion tensor parameters were compared between groups. No significant differences were found in imaging features related to Alzheimer’s disease or gross vascular damage. MCR+ patients had increased LVV and altered diffusion parameters in the superior corona radiata. Ventricular enlargement and microstructural damage of the surrounding white matter tracts could contribute to MCR pathophysiology.
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- 2022
8. The clinical heterogeneity of subjective cognitive decline: a data-driven approach on a population-based sample
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Federica Ribaldi, Elena Rolandi, Roberta Vaccaro, Mauro Colombo, Giovanni Battista Frisoni, and Antonio Guaita
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Male ,Aging ,Alzheimer Disease ,Humans ,Female ,Cognitive Dysfunction ,General Medicine ,Longitudinal Studies ,Geriatrics and Gerontology ,Neuropsychological Tests ,Mental Status and Dementia Tests ,Aged - Abstract
Background subjective cognitive decline (SCD) refers to the subjective experience of cognitive decline in the absence of detectable cognitive impairment. SCD has been largely studied as a risk condition for cognitive decline. Empirical observations suggest that persons with SCD are heterogeneous, including individuals with early Alzheimer’s disease and others with psychological vulnerabilities and/or physical comorbidity. The semiology of SCD is still in its infancy, and the features predicting cognitive decline are poorly defined. The present study aims to identify subgroups of SCD using a data-driven approach and study their clinical evolution across 8 years. Methods the study population is the InveCe.Ab population-based cohort, including cognitively unimpaired people aged 70–74 years and followed for 8 years. Hierarchical cluster analysis (HCA) was carried out to identify distinct SCD subgroups based on nine clinical and cognitive features. Longitudinal changes by baseline SCD status were estimated using linear mixed models for cognitive decline and Cox proportional-hazard model for all-cause dementia risk. Results out of 956 individuals, 513 were female (54%); and the mean age was 72.1 (SD = 1.3), education was 7.2 (3.3), and 370 (39%) reported cognitive complaints (SCD). The HCA resulted in two clusters (SCD1 and SCD2). SCD2 were less educated and had more comorbidities, cardiovascular risk and depressive symptoms than SCD1 and controls. SCD2 presented steeper cognitive decline (Mini-Mental State Examination; β = −0.31) and increased all-cause dementia risk (hazard-ratio = 3.4). Conclusions at the population level, basic clinical information can differentiate individuals with SCD at higher risk of developing dementia, underlining the heterogeneous nature of this population even in a sample selected for a narrow age range, in a specific geographic area.
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- 2022
9. SimulAD: A dynamical model for personalized simulation and disease staging in Alzheimer's disease
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Clément Abi Nader, Federica Ribaldi, Giovanni B. Frisoni, Valentina Garibotto, Philippe Robert, Nicholas Ayache, Marco Lorenzi, E-Patient : Images, données & mOdèles pour la médeciNe numériquE (EPIONE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Côte d'Azur (UCA), Laboratory of Neuroimaging of aging, Memory clinic and LANVIE, Geneva University Hospital and Geneva University, Geneva University Hospitals and Geneva University, Cognition Behaviour Technology (CobTek), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), MNC3 UCA, ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA)
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Aging ,tau Proteins ,Disease progression models ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,Clinical trials ,[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG] ,[STAT.ML]Statistics [stat]/Machine Learning [stat.ML] ,Alzheimer Disease ,mental disorders ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Humans ,Cognitive Dysfunction ,Amyloid beta-Peptides ,General Neuroscience ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology ,Alzheimer's disease ,[STAT]Statistics [stat] ,Disease Progression ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Neurology (clinical) ,Geriatrics and Gerontology ,Atrophy ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,Biomarkers ,Developmental Biology - Abstract
International audience; SimulAD is a computational disease progression model (DPM) originally developed on the ADNI database to simulate the evolution of clinical and imaging markers characteristic of AD, and to quantify the disease severity (DS) of a subject. In this work, we assessed the validity of this estimated DS, as well as the generalization of the DPM, by applying SimulAD on a new cohort from the Geneva Memory Center (GMC). The differences between the estimated DS of healthy, mild cognitive impairment and AD dementia groups were statistically significant (p-values < 0.05; d ≥ 0.8). DS correlated with MMSE (ρ =-0.55), hippocampal atrophy (ρ =-0.62), glucose hypometabolism (ρ =-0.67), amyloid burden (ρ = 0.31) and tau deposition (ρ = 0.62) (p-values < 0.01). Based on the dynamics estimated on the ADNI cohort, we simulated a DPM for the subjects of the GMC cohort. The difference between the temporal evolution of similar biomarkers simulated on the ADNI and GMC cohorts remained below 10%. This study illustrates the robustness and good generalization of SimulAD, highlighting its potential for clinical and pharmaceutical studies.
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- 2022
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10. Towards fingerprinting and identifiability within the Alzheimer’s continuum using resting‐state functional connectivity
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Sara Stampacchia, Saina Asadi, Federica Ribaldi, Szymon Tomczyk, Daniele Altomare, Michela Pievani, Giovanni Frisoni, Enrico Amico, and Valentina Garibotto
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
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11. The heterogeneity of subjective cognitive decline: A data‐driven approach on a population‐based sample
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Elena Rolandi, Federica Ribaldi, Roberta Vaccaro, Mauro Colombo, Giovanni B Frisoni, and Antonio Guaita
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
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12. Cognitive resilience to tau and amyloid burden in a memory clinic population
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Federica Ribaldi, Daniele Altomare, Lara Quattrocchi, Szymon Tomczyk, Valentina Garibotto, and Giovanni B. Frisoni
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2021
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13. Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): Retrospective analyses on the Geneva Memory Clinic cohort
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Aline Mendes, Frédéric Assal, Valentina Garibotto, Giovanni B. Frisoni, Christian Chicherio, Mohamed Eshmawey, Daniele Altomare, and Federica Ribaldi
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Cohort ,Memory clinic ,Metacognition ,Neurology (clinical) ,Geriatrics and Gerontology ,Cognitive decline ,Psychology ,Clinical psychology - Published
- 2020
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14. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status
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Jean-Philippe Ranjeva, Frederik Barkhof, Jorge Jovicich, Régis Bordet, Jill C. Richardson, Elena Rolandi, Magda Tsolaki, Andrea Soricelli, Olivier Blin, Lucilla Parnetti, Marco Salvatore, Claudio Babiloni, Tilman Hensch, Jens Wiltfang, Camillo Marra, José Luis Molinuevo, Libera Cavaliere, Samantha Galluzzi, Moira Marizzoni, Diego Albani, Mira Didic, Clarissa Ferrari, Flavio Nobili, Federica Fusco, Paolo Maria Rossini, Giovanni B. Frisoni, Gianluigi Forloni, Federica Ribaldi, Pierre Payoux, Pieter Jelle Visser, Centro San Giovanni di Dio, Fatebenefratelli, Brescia (IRCCS), Università degli Studi di Brescia [Brescia], Department of Physiology and Pharmacology 'Vittorio Erspamer', Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Neuroscience Department, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Department of Radiology and Nuclear Medicine [Amsterdam], VU University Medical Center [Amsterdam], Institutes of Neurology and Healthcare Engineering, UCL, London, Institut de Neurosciences des Systèmes (INS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Center for Mind/Brain Sciences, University of Trento, Corso Bettini, 31, 38068, Rovereto, TN, Italy, Department of Gerontology, Neurosciences & Orthopedics, Catholic University, Rome, Alzheimer's Disease Unit and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Dipartimento di Neuroscienze, riabilitazione, oftalmologia, genetica e scienze materno-infantili [Genova] (DINOGMI), Universita degli studi di Genova, Section of Neurology, Centre for Memory Disturbances, University of Perugia, Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM] (CEMEREM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Area Neuroscience, IRCCS San Raffaele, Rome, IRCCS SDN Napoli, Department of Neurology (Aristotle University of Thessaloniki), Aristotle University of Thessaloniki, Alzheimer Center Amsterdam, LVR-Clinic for Psychiatry and Psychotherapy, Institutes and Clinics of the University Duisburg-Essen, GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre investigation clinique - Unité de pharmacologie clinique et d'évaluations thérapeutiques (CIC-UPCET), Assistance Publique - Hôpitaux de Marseille (APHM), Laboratory of Neuroimaging of aging, Memory clinic and LANVIE, Geneva University Hospital and Geneva University, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Università degli Studi di Brescia = University of Brescia (UniBs), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Leipzig University, Università degli Studi di Trento (UNITN), Università degli studi di Genova = University of Genoa (UniGe), Università degli Studi di Perugia = University of Perugia (UNIPG), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), and Lille Neurosciences & Cognition - U 1172 (LilNCog)
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Male ,0301 basic medicine ,Oncology ,Apolipoprotein E ,Aging ,Medizin ,Cohort Studies ,0302 clinical medicine ,Cerebrospinal fluid ,Cutoff ,ComputingMilieux_MISCELLANEOUS ,Aged, 80 and over ,biology ,General Neuroscience ,Alzheimer's disease ,3. Good health ,Settore MED/26 - NEUROLOGIA ,Biomarker (medicine) ,Female ,Heterozygote ,medicine.medical_specialty ,CSF cutoff ,Disease progression ,Mild cognitive impairment ,Tau protein ,tau Proteins ,03 medical and health sciences ,Apolipoproteins E ,Neuroimaging ,Alzheimer Disease ,Internal medicine ,mental disorders ,medicine ,Humans ,Cognitive Dysfunction ,Aged ,Amyloid beta-Peptides ,Receiver operating characteristic ,business.industry ,medicine.disease ,Peptide Fragments ,ddc:616.8 ,030104 developmental biology ,[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health ,biology.protein ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Biomarkers ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
Amyloid and tau pathological accumulation should be considered for Alzheimer's disease (AD) definition and before subjects' enrollment in disease-modifying trials. Although age, APOEε4, and sex influence cerebrospinal fluid (CSF) biomarker levels, none of these variables are considered by current normality/abnormality cutoffs. Using baseline CSF data from 2 independent cohorts (PharmaCOG/European Alzheimer's Disease Neuroimaging Initiative and Alzheimer's Disease Neuroimaging Initiative), we investigated the effect of age, APOEε4 status, and sex on CSF Aβ42/P-tau distribution and cutoff extraction by applying mixture models with covariates. The Aβ42/P-tau distribution revealed the presence of 3 subgroups (AD-like, intermediate, control-like) and 2 cutoffs. The identification of the intermediate subgroup and of the higher cutoff was APOEε4 dependent in both cohorts. APOE-specific classification (higher cutoff for APOEε4+, lower cutoff for APOEε4-) showed higher diagnostic accuracy in identifying MCI due to AD compared to single Aβ42 and Aβ42/P-tau cutoffs. APOEε4 influences amyloid and tau CSF markers and AD progression in MCI patients supporting i) the use of APOE-specific cutoffs to identify MCI due to AD and ii) the utility of considering APOE genotype for early AD diagnosis.
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- 2020
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15. Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study
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Elena Rolandi, Sara Mandelli, Alessandra Marcone, Enrica Cavedo, Alessandra Dodich, Roberto Gasparotti, Sandro Iannaccone, Samantha Galluzzi, Claudia Ambrosi, Chiara Cerami, Clarissa Ferrari, Federica Ribaldi, Davide Violi, Nicola Canessa, Harald Hampel, Giulio Munaretto, Andrea Falini, Giovanni B. Frisoni, Rolandi, Elena, Dodich, Alessandra, Galluzzi, Samantha, Ferrari, Clarissa, Mandelli, Sara, Ribaldi, Federica, Munaretto, Giulio, Ambrosi, Claudia, Gasparotti, Roberto, Violi, Davide, Canessa, Nicola, Iannaccone, Sandro, Marcone, Alessandra, Falini, Andrea, Hampel, Harald, Frisoni, Giovanni B., Cerami &, Chiara, Cavedo, Enrica, Rolandi, E, Dodich, A, Galluzzi, S, Ferrari, C, Mandelli, S, Ribaldi, F, Munaretto, G, Ambrosi, C, Gasparotti, R, Violi, D, Canessa, N, Iannaccone, S, Marcone, A, Falini, A, Hampel, H, Frisoni, Gb, Cerami, C, and Cavedo, E
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Male ,Aging ,medicine.medical_specialty ,Psychological intervention ,Physical exercise ,Neuroimaging ,Disease ,ddc:616.0757 ,Primary prevention Alzheimer’s disease ,law.invention ,Non-pharmacologic intervention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Memory ,medicine ,Dementia ,Humans ,030212 general & internal medicine ,Exercise ,Life Style ,Aged Brain/physiopathology Dementia/physiopathology/*therapy Exercise Female Humans Life Style Magnetic Resonance Imaging Male *Memory Memory Disorders/physiopathology/*therapy Middle Aged Alzheimer’s disease Neuroimaging Non-pharmacologic interventions Primary prevention Subjective cognitive decline ,Aged ,Memory Disorders ,Primary prevention ,business.industry ,Incidence (epidemiology) ,Brain ,Cognition ,Alzheimer's disease ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Cognitive training ,Non-pharmacologic interventions ,ddc:618.97 ,Physical therapy ,Subjective cognitive decline ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Abstract
Background: Alzheimer’s Disease (AD) is a multifactorial disorder driven by genetic and modifiable lifestyle risk factors. Lifestyle primary prevention initiatives may reduce the prevalence and incidence of dementia in older adults. Objectives: The E.Mu.N.I study is a randomized controlled trial investigating the effect of multilevel non-pharmacologic interventions on cognitive performances (primary outcome) and structural and vascular brain MRI markers (secondary outcome), as well as markers of brain functional connectivity change (exploratory outcome), in older adults with subjective memory decline (SMD). Here, we present the study design and the baseline features of the sample. Methods: Cognitively intact older adults with SMD, enrolled between February 2016 and June 2017, were randomly assigned to one of the 3 interventions for 1 year: Active Control Intervention (ACI), i.e., educational lessons; Partial Intervention (PI), i.e., homotaurine administration (100 mg/die) and lessons on the Mediterranean diet; Multilevel Intervention (MI), i.e., PI plus computerized cognitive training and physical exercise training. Results: One-hundred and twenty-eight eligible participants were enrolled (66% female; age: 68 ± 5 years). Eighty-two percent of the sample was composed of volunteers with SMD from the community. Participants were randomly allocated to the interventions as follows: ACI (N = 40), PI (N = 44), MI (N = 44). No significant differences among groups emerged on socio-demographic, clinical–neuropsychological variables and MRI markers at baseline. Conclusions: The outcomes obtained from the E.Mu.N.I. study will clarify the efficacy of multilevel non-pharmacologic interventions on cognitive and neuroimaging markers in SMD individuals. This is a crucial step forward for the development of cost-effective non-pharmacologic primary prevention initiatives for AD.
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- 2019
16. P3‐368: PREDICTING AND MONITORING SHORT‐TERM DISEASE PROGRESSION IN A‐MCI PATIENTS WITH PRODROMAL AD USING MRI STRUCTURAL BRAIN BIOMARKERS
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Pierre Payoux, Giovanni B. Frisoni, Andrea Soricelli, Libera Cavaliere, Jill C. Richardson, Jorge Jovicich, Pieter Jelle Visser, Jens Wiltfang, Gianluigi Forloni, Clarissa Ferrari, Régis Bordet, Flavio Nobili, Magda Tsolaki, Lucilla Parnetti, Federica Ribaldi, Paolo Maria Rossini, Peter Schönknecht, Moira Marizzoni, Mira Didic, Olivier Blin, and José Luis Molinuevo
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Oncology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Disease progression ,Term (time) ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Internal medicine ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2018
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17. P2‐370: AMYLOID‐PET FOR MYELIN IMAGING IN ALZHEIMER'S DISEASE
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Giulia Merlin, Paulina Andryszak, Valentina Garibotto, Ugo Paolo Guerra, Frédéric Assal, Giordano Savelli, Anna Tarallo, Moira Marizzoni, Michela Pievani, Giovanni B. Frisoni, Aline Mendes, and Federica Ribaldi
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Pathology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Amyloid pet ,Disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Myelin ,medicine.anatomical_structure ,Developmental Neuroscience ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2018
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18. P4‐098: ASSOCIATION BETWEEN COGNITIVE RESERVE AND WHITE MATTER MICROSTRUCTURAL INTEGRITY IN OLDER ADULTS WITH SUBJECTIVE COGNITIVE DECLINE
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Chiara Cerami, Claudia Ambrosi, Nicola Canessa, Giulio Munaretto, Enrica Cavedo, Roberto Gasparotti, Harald Hampel, Elena Rolandi, Alessandra Dodich, Sandro Iannaccone, Federica Ribaldi, Giovanni B. Frisoni, Daniele Altomare, and Samantha Galluzzi
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Gerontology ,Epidemiology ,Health Policy ,White matter ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,medicine.anatomical_structure ,Developmental Neuroscience ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Cognitive decline ,Psychology ,Association (psychology) ,Cognitive reserve - Published
- 2018
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19. IC‐P‐126: VOLUMETRIC ACCURACY OF A FULLY AUTOMATIC TOOL FOR WHITE MATTER HYPERINTENSITIES (WMHS) SEGMENTATION
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Mira Didic, Tilman Hensch, Agnese Picco, Moira Marizzoni, Ute Fiedler, Stéphanie Bombois, Antonio Ferretti, Jean-Philippe Ranjeva, Robertto Tarducci, Frederik Barkhof, Camillo Marra, Federica Ribaldi, Jorge Jovicich, Joost P.A. Kuijer, Renaud Lopes, Alberto Beltramello, Antonios Drevelegas, Luca Roccatagliata, Giovanni B. Frisoni, Helene Gros-Dagnac, Carlo Cavaliere, David Bartrés-Faz, Marco Aiello, Julien Sein, Peter Schönknecht, Lucilla Parnetti, Andrea Soricelli, Clarissa Ferrari, Flavio Nobili, Karl-Titus Hoffmann, Paolo Maria Rossini, Manos Constantinides, Beatriz Bosch, Magda Tsolaki, Jens Wiltfang, Martina Montalti, Núria Bargalló, Régis Bordet, Bernhard W. Müller, Olivier Blin, Piero Floridi, Franco Alessandrini, Pierre Payoux, Pieter Jelle Visser, and Massimo Caulo
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Epidemiology ,business.industry ,Computer science ,Health Policy ,Pattern recognition ,Hyperintensity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Developmental Neuroscience ,Fully automatic ,Segmentation ,Neurology (clinical) ,Artificial intelligence ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery - Published
- 2018
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20. O1‐13‐01: ROLE OF THE INFLAMMASOME COMPLEX IN AD‐RELATED HIPPOCAMPAL NEURODEGENERATION IN MCI PATIENTS WITH AD PATHOLOGY
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Samantha Galluzzi, Annamaria Cattaneo, Giovanni B. Frisoni, Peter Schönknecht, Flavio Nobili, Nicola Lopizzo, Jean-Philippe Ranjeva, Jorge Jovicich, Federica Ribaldi, Magda Tsolaki, Lucilla Parnetti, Olivier Blin, Paolo Maria Rossini, Diego Albani, Gianluigi Forloni, Moira Marizzoni, Jill C. Richardson, Andrea Soricelli, Régis Bordet, David Bartrés-Faz, Pierre Payoux, Pieter Jelle Visser, and Ute Fiedler
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Pathology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Neurodegeneration ,Hippocampal formation ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Inflammasome complex - Published
- 2018
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21. P4-125: BIOINFORMATIC PIPELINE COMPARISON FOR COMPOSITIONAL ANALYSIS OF THE GUT MICROBIOME IN ALZHEIMER'S PATIENTS
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Marco Salvatore, Peppino Mirabelli, Stefania Provasi, Andrea Soricelli, Thomas Gurry, Moira Marizzoni, Federica Ribaldi, Gilbert Greub, Nicola Lopizzo, Annamaria Cattaneo, and Giovanni B. Frisoni
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Computational biology ,Geriatrics and Gerontology ,Biology ,Pipeline (software) ,Gut microbiome - Published
- 2019
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22. P3-168: FECAL MICROBIAL DIVERSITY IN ALZHEIMER'S PATIENTS
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Marco Salvatore, Moira Marizzoni, Giovanni B. Frisoni, Monica Mazzelli, Paulina Andryszak, Andrea Soricelli, Cristina Festari, Stefania Provasi, Annamaria Cattaneo, Federica Ribaldi, Valentina Nicolosi, and Nicola Lopizzo
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Microbial diversity ,Zoology ,Neurology (clinical) ,Geriatrics and Gerontology ,Biology ,Feces - Published
- 2019
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23. O4-04-03: THE BIOLOGICAL BASIS OF COGNITIVE IMPAIRMENT DUE TO SUSPECTED NON-ALZHEIMER'S PATHOLOGY (SNAP): STUDY DESIGN AND BASELINE COHORT FEATURES
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Alessandra Dodich, Moira Marizzoni, Valentina Garibotto, Christian Chicherio, Paulina Andryszak, Max Scheffler, Cristina Festari, Dina Zekry, Frédéric Assal, Giovanni B. Frisoni, Federica Ribaldi, Aline Mendes, and Karl-Olof Lövblad
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medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Snap ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Internal medicine ,Cohort ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Baseline (configuration management) ,Cognitive impairment - Published
- 2019
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24. [O3–11–06]: NEURAL AND COGNITIVE CORRELATES OF COGNITIVE RESERVE IN SUBJECTIVE COGNITIVE DECLINE
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Enrica Cavedo, Harald Hampel, Elena Rolandi, Giovanni B. Frisoni, Roberto Gasparotti, Samantha Galluzzi, Ilaria Stella, Claudia Ambrosi, and Federica Ribaldi
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Cognition ,Neurology (clinical) ,Geriatrics and Gerontology ,Cognitive decline ,Psychology ,Cognitive psychology ,Cognitive reserve - Published
- 2017
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25. [P3–062]: ACROSS‐SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI‐SITE 3T STUDY
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Federica Ribaldi, Moira Marizzoni, Jorge Jovicich, Clarissa Ferrari, Beatriz Bosch, David Bartrés‐Faz, Bernhard W. Müller, Jens Wiltfang, Ute Fiedler, Luca Roccatagliata, Agnese Picco, Flavio Nobili, Olivier Blin, Stephanie Bombois, Renaud Lopes, Regis Bordet, Julien Sein, Jean‐Philippe Ranjeva, Mira Didic, Helene Gros‐Dagnac, Pierre Payoux, Giada Zoccatelli, Franco Alessandrini, Alberto Beltramello, Núria Bargallo, Antonio Ferretti, Massimo Caulo, Marco Aiello, Carlo Cavaliere, Andrea Soricelli, Lucilla Parnetti, Robertto Tarducci, Piero Floridi, Magda Tsolaki, Manos Constantinides, Antonios Drevelegas, Paolo Maria Rossini, Camillo Marra, Peter Schonknecht, Tilman Hensch, Karl‐Titus Hoffmann, Joost Kuijer, Pieter Jelle Visser, Frederik Barkhof, and Giovanni B. Frisoni
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Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Published
- 2017
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26. [P2–357]: POSTOPERATIVE DELIRIUM IS ASSOCIATED WITH MARKERS OF NEURODEGENERATION BUT NO BRAIN AMYLOIDOSIS
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Michela Pievani, Giovanni B. Frisoni, Enrica Cavedo, Ugo Paolo Guerra, Giorgio Annoni, Mirko Patassini, Luca Matascioli, Elena Rolandi, Colm Cunningham, Samantha Galluzzi, Sabrina Morzenti, Christopher Buckley, Simone Franzoni, Monica Musarra, Lucio Carnevali, Flavio Terragnoli, Giuseppe Bellelli, Silvia Magnaldi, and Federica Ribaldi
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medicine.medical_specialty ,Epidemiology ,business.industry ,Health Policy ,Amyloidosis ,Neurodegeneration ,medicine.disease ,Gastroenterology ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Internal medicine ,Medicine ,Postoperative delirium ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2017
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27. [IC‐P‐167]: ACROSS‐SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI‐SITE 3T STUDY
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Jean-Philippe Ranjeva, Frederik Barkhof, Piero Floridi, Manos Constantinides, Moira Marizzoni, Massimo Caulo, Agnese Picco, Franco Alessandrini, Jorge Jovicich, Antonio Ferretti, Antonios Drevelegas, Régis Bordet, Mira Didic, Paolo Maria Rossini, Andrea Soricelli, Giada Zoccatelli, Pierre Payoux, Lucilla Parnetti, Beatriz Bosch, Magda Tsolaki, Bernhard W. Müller, Giovanni B. Frisoni, Renaud Lopes, Luca Roccatagliata, Jens Wiltfang, Clarissa Ferrari, David Bartrés-Faz, Pieter Jelle Visser, Flavio Nobili, Julien Sein, Helene Gros-Dagnac, Federica Ribaldi, Olivier Blin, Stéphanie Bombois, Tilman Hensch, Camillo Marra, Marco Aiello, Núria Bargalló, Carlo Cavaliere, Peter Schönknecht, Robertto Tarducci, Karl-Titus Hoffmann, Ute Fiedler, Alberto Beltramello, and Joost P.A. Kuijer
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0303 health sciences ,Reproducibility ,Epidemiology ,Computer science ,Health Policy ,Multi site ,Hyperintensity ,03 medical and health sciences ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Developmental Neuroscience ,Segmentation ,Neurology (clinical) ,Session (computer science) ,Geriatrics and Gerontology ,Cartography ,030217 neurology & neurosurgery ,030304 developmental biology - Published
- 2017
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28. Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study
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Colm Cunningham, Silvia Magnaldi, Ugo Paolo Guerra, Mirko Patassini, Flavio Terragnoli, Giorgio Annoni, Michela Pievani, Giovanni B. Frisoni, Elena Rolandi, Sabrina Morzenti, Monica Musarra, Simone Franzoni, Lucio Carnevali, Samantha Galluzzi, Luca Matascioli, Federica Ribaldi, Christopher Buckley, Giuseppe Bellelli, Enrica Cavedo, Rolandi, E, Cavedo, E, Pievani, M, Galluzzi, S, Ribaldi, F, Buckley, C, Cunningham, C, Guerra, U, Musarra, M, Morzenti, S, Magnaldi, S, Patassini, M, Terragnoli, F, Matascioli, L, Franzoni, S, Annoni, G, Carnevali, L, Bellelli, G, and Frisoni, G
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0301 basic medicine ,Male ,Aging ,Pathology ,medicine.medical_specialty ,Amyloid ,Middle temporal gyrus ,Neuroimaging ,Standardized uptake value ,Pilot Projects ,White matter ,ddc:616.89 ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Alzheimer Disease ,Internal medicine ,mental disorders ,medicine ,Humans ,Anterior cingulate cortex ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,Hip Fractures ,General Neuroscience ,Amyloidosis ,Brain ,Delirium ,Alzheimer's disease ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Positron emission tomography ,Positron-Emission Tomography ,Cardiology ,Surgery ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
The aim of the study was to investigate the association between postoperative delirium (POD) and in vivo markers of Alzheimer's disease pathology in nondemented hip fracture surgery patients. POD was assessed with the Confusion Assessment Method. Amyloid load was quantified on (18)F-Flutemetamol positron emission tomography images as standardized uptake value ratio. Secondary outcome measures were gray matter volumes, white matter integrity, and functional connectivity at rest. All the patients with POD (POD+, N = 5) were amyloid negative (standardized uptake value ratio
- Published
- 2017
29. Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus: Linking Functional Connectivity and Clinical Outcome
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Federica Ribaldi, Sara Stampacchia, Giulia Bommarito, Giovanni B. Frisoni, Frédéric Assal, Valentina Garibotto, Alessandra Griffa, Gilles Allali, and Dimitri Van De Ville
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Male ,normal pressure hydrocephalus ,hippocampus ,Disease ,Timed Up and Go test ,Tau Proteins / cerebrospinal fluid ,Hippocampus ,Gastroenterology ,Alzheimer Disease / complications ,Functional connectivity ,default mode network ,Cerebrospinal fluid ,Normal pressure hydrocephalus ,Hippocampus (mythology) ,tau ,Default mode network ,General Neuroscience ,amyloid ,Amyloid beta-Peptides / cerebrospinal fluid ,General Medicine ,Hydrocephalus, Normal Pressure ,Psychiatry and Mental health ,Clinical Psychology ,Peptide Fragments / cerebrospinal fluid ,alzheimer's disease ,Female ,Hydrocephalus, Normal Pressure / complications ,Alzheimer’s disease ,Amyloid ,medicine.medical_specialty ,cerebrospinal-fluid biomarkers ,tau Proteins ,ddc:616.0757 ,csf tap test ,Alzheimer Disease / cerebrospinal fluid ,Alzheimer Disease ,Hydrocephalus, Normal Pressure / cerebrospinal fluid ,Internal medicine ,medicine ,Humans ,mri ,Aged ,Amyloid beta-Peptides ,business.industry ,functional connectivity ,Default Mode Network ,Alzheimer's disease biomarkers ,medicine.disease ,Peptide Fragments ,ddc:616.8 ,Preferred walking speed ,CSF tap test ,ddc:618.97 ,sense organs ,Tau ,Biomarkers / cerebrospinal fluid ,Geriatrics and Gerontology ,business ,Biomarkers - Abstract
Background: Alzheimer's disease (AD) pathology impacts the response to treatment in patients with idiopathic normal pressure hydrocephalus (iNPH), possibly through changes in resting-state functional connectivity (rs-FC)., Objective: To explore the relationship between cerebrospinal fluid biomarkers of AD and the default mode network (DMN)/hippocampal rs-FC in iNPH patients, based on their outcome after cerebrospinal fluid tap test (CSFTT), and in patients with AD., Methods: Twenty-six iNPH patients (mean age: 79.9 +/- 5.9 years; 12 females) underwent MRI and clinical assessment before and after CSFTT and were classified as responders (Resp) or not (NResp), based on the improvement at the timed up and go test and walking speed. Eleven AD patients (mean age: 70.91 +/- 5.2 years; 5 females), matched to iNPH for cognitive status, were also included. DMN and hippocampal rs-FC was related to amyloid-beta(42) and phosphorylated tau (pTau) levels., Results: Lower amyloid-beta(42 )levels were associated with reduced inter- and intra-network rs-FC in NResp, and the interaction between amyloid-beta(42 )and rs-FC was a predictor of outcome after CSFTT. The rs-FC between DMN and salience networks positively correlated to amyloid-beta(42) levels in both NResp and AD patients. The increase in the inter-network rs-FC after CSFTT was associated with higher pTau and lower amyloid-beta(42) levels in NResp, and to lower pTau levels in Resp., Conclusion: Amyloid-beta(42 )and pTau impact on rs-FC and its changes after CSFTT in iNPH patients. The interaction between AD biomarkers and rs-FC might explain the responder status in iNPH.
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