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The third meeting of the European Social Forum (ESF) was held in London during October 2004 with a broad ranging formal agenda and a penumbra of affiliated workshops and cultural activities. We draw on participant observation in all sessions dealing with science and genomics and offer an evaluation of Rothman's (2000) argument that NGOs and protest movements have a vital role to play in consolidating and disseminating the UN Universal Declaration on the Human Genome and Human Rights. The paper positions the ESF as a constituent part of the World Social Forum network, identifies the key ESF networks and actors concerned with science and genomics, and analyses the various action, grievance and mobilisation frames generated within the 2004 ESF. It concludes with a discussion of the potential of this networked movement milieu to realise the goals identified in Rothman's work. [ABSTRACT FROM AUTHOR]