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47 results on '"Fraser, Claire"'

1. Genome Analysis of Multiple Pathogenic Isolates of Streptococcus agalactiae: Implications for the Microbial "Pan-Genome"

Author

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., Angiuoli, Samuel V., Crabtree, Jonathan, Jones, Amanda L., Durkin, A. Scott, DeBoy, Robert T., Davidsen, Tanja M., Mora, Marirosa, Scarselli, Maria, Peterson, Jeremy D., Hauser, Christopher R., Sundaram, Jaideep P., Nelson, William C., Madupu, Ramana, Brinkac, Lauren M., Dodson, Robert J., Rosovitz, Mary J., Sullivan, Steven A., Daugherty, Sean C., Haft, Daniel H., Selengut, Jeremy, Gwinn, Michelle L., Zhou, Liwei, Zafar, Nikhat, Khouri, Hoda, Radune, Diana, Dimitrov, George, Watkins, Kisha, Smith, Shannon, Utterback, Teresa R., White, Owen, Rubens, Craig E., Grandi, Guido, Madoff, Lawrence C., Kasper, Dennis L., Telford, John L., Wessels, Michael R., Rappuoli, Rino, and Fraser, Claire M.

Published
2005

2. The Psychrophilic Lifestyle as Revealed by the Genome Sequence of Colwellia psychrerythraea 34H through Genomic and Proteomic Analyses

Author

Methé, Barbara A., Nelson, Karen E., Deming, Jody W., Momen, Bahram, Melamud, Eugene, Zhang, Xijun, Moult, John, Madupu, Ramana, Nelson, William C., Dodson, Robert J., Brinkac, Lauren M., Daugherty, Sean C., Durkin, Anthony S., DeBoy, Robert T., Kolonay, James F., Sullivan, Steven A., Zhou, Liwei, Davidsen, Tanja M., Wu, Martin, Huston, Adrienne L., Lewis, Matthew, Weaver, Bruce, Weidman, Janice F., Khouri, Hoda, Utterback, Terry R., Feldblyum, Tamara V., and Fraser, Claire M.

Published
2005

3. The Genome of the African Trypanosome Trypanosoma brucei

Author

Berriman, Matthew, Ghedin, Elodie, Hertz-Fowler, Christiane, Blandin, Gaëlle, Renauld, Hubert, Bartholomeu, Daniella C., Lennard, Nicola J., Caler, Elisabet, Hamlin, Nancy E., Haas, Brian, Böhme, Ulrike, Hannick, Linda, Aslett, Martin A., Shallom, Joshua, Marcello, Lucio, Hou, Lihua, Wickstead, Bill, Arrowsmith, Claire, Atkin, Rebecca J., Barron, Andrew J., Bringaud, Frederic, Brooks, Karen, Carrington, Mark, Cherevach, Inna, Chillingworth, Tracey-Jane, Churcher, Carol, Clark, Louise N., Corton, Craig H., Cronin, Ann, Davies, Rob M., Doggett, Jonathon, Djikeng, Appolinaire, Feldblyum, Tamara, Field, Mark C., Fraser, Audrey, Goodhead, Ian, Hance, Zahra, Harper, David, Harris, Barbara R., Hauser, Heidi, Hostetler, Jessica, Ivens, Al, Jagels, Kay, Johnson, David, Johnson, Justin, Jones, Kristine, Kerhornou, Arnaud X., Koo, Hean, Larke, Natasha, Landfear, Scott, Larkin, Christopher, Leech, Vanessa, Line, Alexandra, Lord, Angela, MacLeod, Annette, Mooney, Paul J., Moule, Sharon, Morgan, Gareth W., Mungall, Karen, Norbertczak, Halina, Ormond, Doug, Pai, Grace, Peacock, Chris S., Peterson, Jeremy, Quail, Michael A., Rabbinowitsch, Ester, Rajandream, Marie-Adele, Reitter, Chris, Salzberg, Steven L., Sanders, Mandy, Schobel, Seth, Sharp, Sarah, Simmonds, Mark, Simpson, Anjana J., Tallon, Luke, Tait, Andrew, Tivey, Adrian R., Van Aken, Susan, Walker, Danielle, Wanless, David, Wang, Shiliang, White, Brian, White, Owen, Whitehead, Sally, Woodward, John, Wortman, Jennifer, Adams, Mark D., Embley, T. Martin, Gull, Keith, Ullu, Elisabetta, Barry, J. David, Fairlamb, Alan H., Opperdoes, Fred, Barrell, Barclay G., Donelson, John E., Hall, Neil, Fraser, Claire M., Melville, Sara E., and El-Sayed, Najib M.

Published
2005

4. The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

Author

El-Sayed, Najib M., Myler, Peter J., Bartholomeu, Daniella C., Nilsson, Daniel, Aggarwal, Gautam, Tran, Anh-Nhi, Ghedin, Elodie, Worthey, Elizabeth A., Delcher, Arthur L., Blandin, Gaëlle, Westenberger, Scott J., Caler, Elisabet, Cerqueira, Gustavo C., Anupama, Atashi, Arner, Erik, Åslund, Lena, Attipoe, Philip, Bontempi, Esteban, Bringaud, Frédéric, Burton, Peter, Cadag, Eithon, Campbell, David A., Carrington, Mark, Crabtree, Jonathan, Darban, Hamid, da Silveira, Jose Franco, de Jong, Pieter, Edwards, Kimberly, Englund, Paul T., Fazelina, Gholam, Feldblyum, Tamara, Ferella, Marcela, Frasch, Alberto Carlos, Gull, Keith, Horn, David, Hou, Lihua, Huang, Yiting, Kindlund, Ellen, Klingbeil, Michele, Kluge, Sindy, Koo, Hean, Lacerda, Daniela, Levin, Mariano J., Lorenzi, Hernan, Louie, Tin, Machado, Carlos Renato, McCulloch, Richard, McKenna, Alan, Mizuno, Yumi, Mottram, Jeremy C., Nelson, Siri, Ochaya, Stephen, Osoegawa, Kazutoyo, Pai, Grace, Parsons, Marilyn, Pentony, Martin, Pettersson, Ulf, Pop, Mihai, Ramirez, Jose Luis, Rinta, Joel, Robertson, Laura, Salzberg, Steven L., Sanchez, Daniel O., Seyler, Amber, Sharma, Reuben, Shetty, Jyoti, Simpson, Anjana J., Sisk, Ellen, Tammi, Martti T., Tarleton, Rick, Teixeira, Santuza, Van Aken, Susan, Vogt, Christy, Ward, Pauline N., Wickstead, Bill, Wortman, Jennifer, White, Owen, Fraser, Claire M., Stuart, Kenneth D., and Andersson, Björn

Published
2005

5. Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes

Author

Gardner, Malcolm J., Bishop, Richard, Shah, Trushar, de Villiers, Etienne P., Carlton, Jane M., Hall, Neil, Ren, Qinghu, Paulsen, Ian T., Pain, Arnab, Berriman, Matthew, Sato, Shigeharu, Ralph, Stuart A., Mann, David J., Xiong, Zikai, Shallom, Shamira J., Weidman, Janice, Jiang, Lingxia, Lynn, Jeffery, Weaver, Bruce, Shoaibi, Azadeh, Domingo, Alexander R., Wasawo, Delia, Crabtree, Jonathan, Wortman, Jennifer R., Haas, Brian, Angiuoli, Samuel V., Creasy, Todd H., Lu, Charles, Suh, Bernard, Silva, Joana C., Utterback, Teresa R., Feldblyum, Tamara V., Pertea, Mihaela, Allen, Jonathan, Nierman, William C., Salzberg, Steven L., White, Owen R., Fitzhugh, Henry A., Morzaria, Subhash, Venter, J. Craig, Fraser, Claire M., and Nene, Vishvanath

Published
2005

6. The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans

Author

Loftus, Brendan J., Fung, Eula, Roncaglia, Paola, Rowley, Don, Amedeo, Paolo, Bruno, Dan, Vamathevan, Jessica, Miranda, Molly, Anderson, Iain J., Fraser, James A., Allen, Jonathan E., Bosdet, Ian E., Brent, Michael R., Chiu, Readman, Doering, Tamara L., Donlin, Maureen J., D'Souza, Cletus A., Fox, Deborah S., Grinberg, Viktoriya, Fu, Jianmin, Fukushima, Marilyn, Haas, Brian J., Huang, James C., Janbon, Guilhem, Koo, Hean L., Krzywinski, Martin I., Kwon-Chung, June K., Lengeler, Klaus B., Maiti, Rama, Marra, Marco A., Marra, Robert E., Mathewson, Carrie A., Mitchell, Thomas G., Pertea, Mihaela, Riggs, Florenta R., Salzberg, Steven L., Schein, Jacqueline E., Shvartsbeyn, Alla, Shin, Heesun, Shumway, Martin, Specht, Charles A., Suh, Bernard B., Tenney, Aaron, Utterback, Terry R., Wickes, Brian L., Wortman, Jennifer R., Wye, Natasja H., Kronstad, James W., Lodge, Jennifer K., Heitman, Joseph, Davis, Ronald W., Fraser, Claire M., and Hyman, Richard W.

Published
2005

7. Genome Sequence of the PCE-Dechlorinating Bacterium Dehalococcoides ethenogenes

Author

Seshadri, Rekha, Adrian, Lorenz, Fouts, Derrick E., Eisen, Jonathan A., Phillippy, Adam M., Methe, Barbara A., Ward, Naomi L., Nelson, William C., Deboy, Robert T., Khouri, Hoda M., Kolonay, James F., Dodson, Robert J., Daugherty, Sean C., Brinkac, Lauren M., Sullivan, Steven A., Madupu, Ramana, Nelson, Karen E., Kang, Katherine H., Impraim, Marjorie, Tran, Kevin, Robinson, Jeffrey M., Forberger, Heather A., Fraser, Claire M., Zinder, Stephen H., and Heidelberg, John F.

Published
2005

8. Structural Flexibility in the Burkholderia mallei Genome

Author

Nierman, William C., DeShazer, David, Kim, H. Stanley, Tettelin, Herve, Nelson, Karen E., Feldblyum, Tamara, Ulrich, Ricky L., Ronning, Catherine M., Brinkac, Lauren M., Daugherty, Sean C., Davidsen, Tanja D., Deboy, Robert T., Dimitrov, George, Dodson, Robert J., Durkin, A. Scott, Gwinn, Michelle L., Haft, Daniel H., Khouri, Hoda, Kolonay, James F., Madupu, Ramana, Mohammoud, Yasmin, Nelson, William C., Radune, Diana, Romero, Claudia M., Sarria, Saul, Selengut, Jeremy, Shamblin, Christine, Sullivan, Steven A., White, Owen, Yu, Yan, Zafar, Nikhat, Zhou, Liwei, Fraser, Claire M., and Greenberg, E. Peter

Published
2004

11. Identification of Anthrax Toxin Genes in a Bacillus cereus Associated with an Illness Resembling Inhalation Anthrax

Author

Hoffmaster, Alex R., Ravel, Jacques, Rasko, David A., Chapman, Gail D., Chute, Michael D., Marston, Chung K., De, Barun K., Sacchi, Claudio T., Fitzgerald, Collette, Mayer, Leonard W., Priest, Fergus G., Barker, Margaret, Jiang, Lingxia, Cer, Regina Z., Rilstone, Jennifer, Peterson, Scott N., Weyant, Robbin S., Galloway, Darrell R., Read, Timothy D., Popovic, Tanja, Fraser, Claire M., and Robbins, John B.

Published
2004

12. Comparison of the Genome of the Oral Pathogen Treponema denticola with Other Spirochete Genomes

Author

Seshadri, Rekha, Tettelin, Hervé, Eisen, Jonathan A., Heidelberg, John F., Dodson, Robert J., Davidsen, Tanja M., DeBoy, Robert T., Fouts, Derrick E., Haft, Dan H., Selengut, Jeremy, Ren, Qinghu, Brinkac, Lauren M., Madupu, Ramana, Kolonay, Jamie, Durkin, Scott A., Daugherty, Sean C., Shetty, Jyoti, Shvartsbeyn, Alla, Gebregeorgis, Elizabeth, Geer, Keita, Tsegaye, Getahun, Malek, Joel, Ayodeji, Bola, Shatsman, Sofiya, McLeod, Michael P., Šmajs, David, Howell, Jerrilyn K., Pal, Sangita, Amin, Anita, Vashisth, Pankaj, McNeill, Thomas Z., Xiang, Qin, Sodergren, Erica, Baca, Ernesto, Weinstock, George M., Norris, Steven J., Fraser, Claire M., Paulsen, Ian T., and Haselkorn, Robert

Published
2004

14. The Complete Genome Sequence of the Arabidopsis and Tomato Pathogen Pseudomonas syringae pv. tomato DC3000

Author

Buell, C. Robin, Joardar, Vinita, Lindeberg, Magdalen, Selengut, Jeremy, Paulsen, Ian T., Gwinn, Michelle L., Dodson, Robert J., Deboy, Robert T., Durkin, A. Scott, Kolonay, James F., Madupu, Ramana, Daugherty, Sean, Brinkac, Lauren, Beanan, Maureen J., Haft, Daniel H., Nelson, William C., Davidsen, Tanja, Zafar, Nikhat, Zhou, Liwei, Liu, Jia, Yuan, Qiaoping, Khouri, Hoda, Fedorova, Nadia, Tran, Bao, Russell, Daniel, Berry, Kristi, Utterback, Teresa, Van Aken, Susan E., Feldblyum, Tamara V., D'Ascenzo, Mark, Deng, Wen-Ling, Ramos, Adela R., Alfano, James R., Cartinhour, Samuel, Chatterjee, Arun K., Delaney, Terrence P., Lazarowitz, Sondra G., Martin, Gregory B., Schneider, David J., Tang, Xiaoyan, Bender, Carol L., White, Owen, Fraser, Claire M., and Collmer, Alan

Published
2003

15. Complete Genome Sequence of the Q-Fever Pathogen Coxiella burnetii

Author

Seshadri, Rekha, Paulsen, Ian T., Eisen, Jonathan A., Read, Timothy D., Nelson, Karen E., Nelson, William C., Ward, Naomi L., Tettelin, Hervé, Davidsen, Tanja M., Beanan, Maureen J., Deboy, Robert T., Daugherty, Sean C., Brinkac, Lauren M., Madupu, Ramana, Dodson, Robert J., Khouri, Hoda M., Lee, Kathy H., Carty, Heather A., Scanlan, David, Heinzen, Robert A., Thompson, Herbert A., Samuel, James E., Fraser, Claire M., and Heidelberg, John F.

Published
2003

16. The Genome Sequence of the Malaria Mosquito Anopheles gamblae

Author

Holt, Robert A., Subramanian, G. Mani, Halpern, Aaron, Sutton, Granger G., Charlab, Rosane, Nusskern, Deborah R., Wincker, Patrick, Clark, Andrew G., Wides, Ron, Salzberg, Steven L., Loftus, Brendan, Yandell, Mark, Majoros, William H., Rusch, Douglas B., Lai, Zhongwu, Kraft, Cheryl L., Abril, Josep F., Anthouard, Veronique, Arensburger, Peter, Atkinson, Peter W., Baden, Holly, de Berardinis, Veronique, Baldwin, Danita, Benes, Vladimir, Biedler, Jim, Blass, Claudia, Bolanos, Randall, Boscus, Didier, Barnstead, Mary, Cai, Shuang, Chatuverdi, Kabir, Christophides, George K., Chrystal, Mathew A., Clamp, Michele, Cravchik, Anibal, Curwen, Val, Dana, Ali, Delcher, Art, Dew, Ian, Evans, Cheryl A., Flanigan, Michael, Grundschober-Freimoser, Anne, Friedli, Lisa, Gu, Zhiping, Guan, Ping, Guigo, Roderic, Hillenmeyer, Maureen E., Hladun, Susanne L., Hogan, James R., Hong, Young S., Hoover, Jeffrey, Jaillon, Olivier, Ke, Zhaoxi, Kodira, Chinnappa, Kokoza, Elena, Koutsos, Anastasios, Letunic, Ivica, Levitsky, Alex, Liang, Yong, Lin, Jhy-Jhu, Lobo, Neil F., Lopez, John R., Malek, Joel A., McIntosh, Tina C., Meister, Stephan, Miller, Jason, Mobarry, Clark, Mongin, Emmanuel, Murphy, Sean D., O'Brochta, David A., Pfannkoch, Cynthia, Qi, Rong, Regier, Megan A., Remington, Karin, Shao, Hongguang, Sharakhova, Maria V., Sitter, Cynthia D., Shetty, Jyoti, Smith, Thomas J., Strong, Renee, Sun, Jingtao, Thomasova, Dana, Ton, Lucas Q., Topalis, Pantelis, Tu, Zhijian, Unger, Maria F., Walenz, Brian, Wang, Aihui, Wang, Jian, Wang, Mei, Wang, Xuelan, Woodford, Kerry J., Wortman, Jennifer R., Wu, Martin, Yao, Alison, Zdobnov, Evgeny M., Zhang, Hongyu, Zhao, Qi, Zhao, Shaying, Zhu, Shiaoping C., Zhimulev, Igor, Coluzzi, Mario, della Torre, Alessandra, Roth, Charles W., Louis, Christos, Kalush, Francis, Mural, Richard J., Myers, Eugene W., Adams, Mark D., Smith, Hamilton O., Broder, Samuel, Gardner, Malcolm J., Fraser, Claire M., Birney, Ewan, Bork, Peer, Brey, Paul T., Venter, J. Craig, Weissenbach, Jean, Kafatos, Fotis C., Collins, Frank H., and Hoffman, Stephen L.

Published
2002

17. The Brucella suis Genome Reveals Fundamental Similarities between Animal and Plant Pathogens and Symbionts

Author

Paulsen, Ian T., Seshadri, Rekha, Nelson, Karen E., Eisen, Jonathan A., Heidelberg, John F., Read, Timothy D., Dodson, Robert J., Umayam, Lowell, Brinkac, Lauren M., Beanan, Maureen J., Daugherty, Sean C., Deboy, Robert T., Durkin, A. Scott, Kolonay, James F., Madupu, Ramana, Nelson, William C., Ayodeji, Bola, Kraul, Margaret, Shetty, Jyoti, Malek, Joel, van Aken, Susan E., Riedmuller, Steven, Tettelin, Herve, Gill, Steven R., White, Owen, Salzberg, Steven L., Hoover, David L., Lindler, Luther E., Halling, Shirley M., Boyle, Stephen M., and Fraser, Claire M.

Published
2002

18. Complete Genome Sequence and Comparative Genomic Analysis of an Emerging Human Pathogen, Serotype V Streptococcus agalactiae

Author

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., Paulsen, Ian T., Nelson, Karen E., Margarit, Immaculada, Read, Timothy D., Madoff, Lawrence C., Wolf, Alex M., Beanan, Maureen J., Brinkac, Lauren M., Daugherty, Sean C., DeBoy, Robert T., Durkin, A. Scott, Kolonay, James F., Madupu, Ramana, Lewis, Matthew R., Radune, Diana, Fedorova, Nadezhda B., Scanlan, David, Khouri, Hoda, Mulligan, Stephanie, Carty, Heather A., Cline, Robin T., Van Aken, Susan E., Gill, John, Scarselli, Maria, Mora, Marirosa, Iacobini, Emilia T., Brettoni, Cecilia, Galli, Giuliano, Mariani, Massimo, Vegni, Filippo, Maione, Domenico, Rinaudo, Daniela, Rappuoli, Rino, Telford, John L., Kasper, Dennis L., Grandi, Guido, and Fraser, Claire M.

Published
2002

19. The Complete Genome Sequence of Chlorobium tepidum TLS, A Photosynthetic, Anaerobic, Green-Sulfur Bacterium

Author

Eisen, Jonathan A., Nelson, Karen E., Paulsen, Ian T., Heidelberg, John F., Wu, Martin, Dodson, Robert J., Deboy, Robert, Gwinn, Michelle L., Nelson, William C., Haft, Daniel H., Hickey, Erin K., Peterson, Jeremy D., Durkin, A. Scott, Kolonay, James L., Yang, Fan, Holt, Ingeborg, Umayam, Lowell A., Mason, Tanya, Brenner, Michael, Shea, Terrance P., Parksey, Debbie, Nierman, William C., Feldblyum, Tamara V., Hansen, Cheryl L., Craven, M. Brook, Radune, Diana, Vamathevan, Jessica, Khouri, Hoda, White, Owen, Gruber, Tanja M., Ketchum, Karen A., Venter, J. Craig, Tettelin, Hervé, Bryant, Donald A., and Fraser, Claire M.

Published
2002

21. Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

Author

Tettelin, Hervé, Nelson, Karen E., Paulsen, Ian T., Eisen, Jonathan A., Read, Timothy D., Peterson, Scott, Heidelberg, John, DeBoy, Robert T., Haft, Daniel H., Dodson, Robert J., Durkin, A. Scott, Gwinn, Michelle, Kolonay, James F., Nelson, William C., Peterson, Jeremy D., Umayam, Lowell A., White, Owen, Salzberg, Steven L., Lewis, Matthew R., Radune, Diana, Holtzapple, Erik, Khouri, Hoda, Wolf, Alex M., Utterback, Terry R., Hansen, Cheryl L., McDonald, Lisa A., Feldblyum, Tamara V., Angiuoli, Samuel, Dickinson, Tanja, Hickey, Erin K., Holt, Ingeborg E., Loftus, Brendan J., Yang, Fan, Smith, Hamilton O., Venter, J. Craig, Dougherty, Brian A., Morrison, Donald A., Hollingshead, Susan K., and Fraser, Claire M.

Published
2001

22. Complete Genome Sequence of Caulobacter crescentus

Author

Nierman, William C., Feldblyum, Tamara V., Laub, Michael T., Paulsen, Ian T., Nelson, Karen E., Eisen, Jonathan, Heidelberg, John F., Alley, M. R. K., Ohta, Noriko, Maddock, Janine R., Potocka, Isabel, Nelson, William C., Newton, Austin, Stephens, Craig, Phadke, Nikhil D., Ely, Bert, DeBoy, Robert T., Dodson, Robert J., Durkin, A. Scott, Gwinn, Michelle L., Haft, Daniel H., Kolonay, James F., Smit, John, Craven, M. B., Khouri, Hoda, Shetty, Jyoti, Berry, Kristi, Utterback, Teresa, Tran, Kevin, Wolf, Alex, Vamathevan, Jessica, Ermolaeva, Maria, White, Owen, Salzberg, Steven L., Venter, J. Craig, Shapiro, Lucy, and Fraser, Claire M.

Published
2001

23. Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58

Author

Tettelin, Hervé, Saunders, Nigel J., Heidelberg, John, Jeffries, Alex C., Nelson, Karen E., Eisen, Jonathan A., Ketchum, Karen A., Hood, Derek W., Peden, John F., Dodson, Robert J., Nelson, William C., Gwinn, Michelle L., DeBoy, Robert, Peterson, Jeremy D., Hickey, Erin K., Haft, Daniel H., Salzberg, Steven L., White, Owen, Fleischmann, Robert D., Dougherty, Brian A., Mason, Tanya, Ciecko, Anne, Parksey, Debbie S., Blair, Eric, Cittone, Henry, Clark, Emily B., Cotton, Matthew D., Utterback, Terry R., Khouri, Hoda, Qin, Haiying, Vamathevan, Jessica, Gill, John, Scarlato, Vincenzo, Masignani, Vega, Pizza, Mariagrazia, Grandi, Guido, Sun, Li, Smith, Hamilton O., Fraser, Claire M., Moxon, E. Richard, Rappuoli, Rino, and Venter, J. Craig

Published
2000

25. Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1

Author

White, Owen, Eisen, Jonathan A., Heidelberg, John F., Hickey, Erin K., Peterson, Jeremy D., Dodson, Robert J., Haft, Daniel H., Gwinn, Michelle L., Nelson, William C., Richardson, Delwood L., Moffat, Kelly S., Qin, Haiying, Jiang, Lingxia, Pamphile, Wanda, Crosby, Marie, Shen, Mian, Vamathevan, Jessica J., Lam, Peter, McDonald, Lisa, Utterback, Terry, Zalewski, Celeste, Makarova, Kira S., Aravind, L., Daly, Michael J., Minton, Kenneth W., Fleischmann, Robert D., Ketchum, Karen A., Nelson, Karen E., Salzberg, Steven, Smith, Hamilton O., Venter, J. Craig, and Fraser, Claire M.

Published
1999

27. Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum

Author

Gardner, Malcolm J., Tettelin, Hervé, Carucci, Daniel J., Cummings, Leda M., Aravind, L., Koonin, Eugene V., Shallom, Shamira, Mason, Tanya, Yu, Kelly, Fujii, Claire, Pederson, James, Shen, Kun, Jing, Junping, Aston, Christopher, Lai, Zhongwu, Schwartz, David C., Pertea, Mihaela, Salzberg, Steven, Zhou, Lixin, Sutton, Granger G., Clayton, Rebecca, White, Owen, Smith, Hamilton O., Fraser, Claire M., Adams, Mark D., Venter, J. Craig, and Hoffman, Stephen L.

Published
1998

28. Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete

Author

Fraser, Claire M., Norris, Steven J., Weinstock, George M., White, Owen, Sutton, Granger G., Dodson, Robert, Gwinn, Michelle, Hickey, Erin K., Clayton, Rebecca, Ketchum, Karen A., Sodergren, Erica, Hardham, John M., McLeod, Michael P., Salzberg, Steven, Peterson, Jeremy, Khalak, Hanif, Richardson, Delwood, Howell, Jerrilyn K., Chidambaram, Monjula, Utterback, Teresa, McDonald, Lisa, Artiach, Patricia, Bowman, Cheryl, Cotton, Matthew D., Fujii, Claire, Garland, Stacey, Hatch, Bonnie, Horst, Kurt, Roberts, Kevin, Sandusky, Mina, Weidman, Janice, Smith, Hamilton O., and Venter, J. Craig

Published
1998

29. Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

Author

Bult, Carol J., White, Owen, Olsen, Gary J., Zhou, Lixin, Fleischmann, Robert D., Sutton, Granger G., Blake, Judith A., FitzGerald, Lisa M., Clayton, Rebecca A., Gocayne, Jeannine D., Kerlavage, Anthony R., Dougherty, Brian A., Tomb, Jean-Francois, Adams, Mark D., Reich, Claudia I., Overbeek, Ross, Kirkness, Ewen F., Weinstock, Keith G., Merrick, Joseph M., Glodek, Anna, Scott, John L., Weidman, Janice F., Fuhrmann, Joyce L., Nguyen, Dave, Utterback, Teresa R., Kelley, Jenny M., Peterson, Jeremy D., Sadow, Paul W., Hanna, Michael C., Cotton, Matthew D., Roberts, Kevin M., Hurst, Margaret A., Kaine, Brian P., Borodovsky, Mark, Klenk, Hans-Peter, Fraser, Claire M., Smith, Hamilton O., Woese, Carl R., and Venter, J. Craig

Published
1996

30. Identification of a Universal Group B Streptococcus Vaccine by Multiple Genome Screen

Author

Maione, Domenico, Margarit, Immaculada, Rinaudo, Cira D., Masignani, Vega, Mora, Marirosa, Scarselli, Maria, Tettelin, Hervé, Brettoni, Cecilia, Iacobini, Emilia T., Rosini, Roberto, D'Agostino, Nunzio, Miorin, Lisa, Buccato, Scilla, Mariani, Massimo, Galli, Giuliano, Nogarotto, Renzo, Dei, Vincenzo Nardi, Vegni, Filipo, Fraser, Claire, Mancuso, Giuseppe, Teti, Giuseppe, Madoff, Lawrence C., Paoletti, Lawrence C., Rappuoli, Rino, Kasper, Dennis L., Telford, John L., and Grandi, Guido

Published
2005

32. Whole-Genome Random Sequencing and Assembly of Haemophilus Influenzae Rd

Author

Fleischmann, Robert D., Adams, Mark D., White, Owen, Clayton, Rebecca A., Kirkness, Ewen F., Kerlavage, Anthony R., Bult, Carol J., Tomb, Jean-Francois, Dougherty, Brian A., Merrick, Joseph M., McKenney, Keith, Sutton, Granger, FitzHugh, Will, Fields, Chris, Gocyne, Jeannie D., Scott, John, Shirley, Robert, Liu, Li-Ing, Glodek, Anna, Kelley, Jenny M., Weidman, Janice F., Phillips, Cheryl A., Spriggs, Tracy, Hedblom, Eva, Cotton, Matthew D., Utterback, Teresa R., Hanna, Michael C., Nguyen, David T., Saudek, Deborah M., Brandon, Rhonda C., Fine, Leah D., Fritchman, Janice L., Fuhrmann, Joyce L., Geoghagen, N. S. M., Gnehm, Cheryl L., McDonald, Lisa A., Small, Keith V., Fraser, Claire M., Smith, Hamilton O., and Venter, J. Craig

Published
1995

33. The Minimal Gene Complement of Mycoplasma genitalium

Author

Fraser, Claire M., Gocayne, Jeannine D., White, Owen, Adams, Mark D., Clayton, Rebecca A., Fleischmann, Robert D., Bult, Carol J., Kerlavage, Anthony R., Sutton, Granger, Kelley, Jenny M., Fritchman, Janice L., Weidman, Janice F., Small, Keith V., Sandusky, Mina, Furhmann, Joyce, Nguyen, David, Utterback, Teresa R., Saudek, Deborah M., Phillips, Cheryl A., Merrick, Joseph M., Tomb, Jean-Francois, Dougherty, Brian A., Bott, Kenneth F., Hu, Ping-Chuan, Lucier, Thomas S., Peterson, Scott N., Smith, Hamilton O., Hutchison, Clyde A., and Venter, J. Craig

Published
1995

35. Comparative Sequencing

Author

Jacobs, William, Brennan, Patrick, Curlin, George, Ginsberg, Ann, Adams, Mark, Fleischmann, Robert, Fraser, Claire, Venter, J. Craig, Shinnick, Thomas, Bishai, William, Smith, Hamilton, Stover, Ken, and Hatfull, Graham

Published
1996

36. Comparative genomics and stx phage characterization of LEE-negative Shiga toxin-producing Escherichia coli.

Author

Steyert, Susan R., Sahl, JasonW., Fraser, Claire M., Teel, Louise D., Scheutz, Flemming, and Rasko, David A.

Subjects
GENOMICS, ESCHERICHIA coli diseases, SHIGELLA, GENOMES, DIARRHEA, ENTEROCYTES
Abstract

Infection by Escherichia coli and Shigella species are among the leading causes of death due to diarrheal disease in the world. Shiga toxin-producing E. coli (STEC) that do not encode the locus of enterocyte effacement (LEE-negative STEC) often possess Shiga toxin gene variants and have been isolated from humans and a variety of animal sources. In this study, we compare the genomes of nine LEE-negative STEC harboring various stx alleles with four complete reference LEE-positive STEC isolates. Compared to a representative collection of prototype E. coli and Shigella isolates representing each of the pathotypes, the whole genome phylogeny demonstrated that these isolates are diverse. Whole genome comparative analysis of the 13 genomes revealed that in addition to the absence of the LEE pathogenicity island, phage-encoded genes including non-LEE encoded effectors, were absent from all nine LEE-negative STEC genomes. Several plasmid-encoded virulence factors reportedly identified in LEE-negative STEC isolates were identified in only a subset of the nine LEE-negative isolates further confirming the diversity of this group. In combination with whole genome analysis, we characterized the lambdoid phages harboring the various stx alleles and determined their genomic insertion sites. Although the integrase gene sequence corresponded with genomic location, itwas not correlated with stx variant, further highlighting the mosaic nature of these phages. The transcription of these phages in different genomic backgrounds was examined. Expression of the Shiga toxin genes, stx1 and/or stx2, as well as the Q genes, were examined with quantitative reverse transcriptase polymerase chain reaction assays. A wide range of basal and induced toxin induction was observed. Overall, this is a first significant foray into the genome space of this unexplored group of emerging and divergent pathogens. [ABSTRACT FROM AUTHOR]

Published
2012
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37. Genome Stability of Lyme Disease Spirochetes: Comparative Genomics of Borrelia burgdorferi Plasmids.

Author

Casjens, Sherwood R., Mongodin, Emmanuel F., Wei-Gang Qiu, Luft, Benjamin J., Schutzer, Steven E., Gilcrease, Eddie B., Wai Mun Huang, Vujadinovic, Marija, Aron, John K., Vargas, Levy C., Freeman, Sam, Radune, Diana, Weidman, Janice F., Dimitrov, George I., Khouri, Hoda M., Sosa, Julia E., Halpin, Rebecca A., Dunn, John J., and Fraser, Claire M.

Subjects
LYME disease, BORRELIA burgdorferi, COMMUNICABLE diseases in animals, GENOMES, PLASMIDS
Abstract

Lyme disease is the most common tick-borne human illness in North America. In order to understand the molecular pathogenesis, natural diversity, population structure and epizootic spread of the North American Lyme agent, Borrelia burgdorferi sensu stricto, a much better understanding of the natural diversity of its genome will be required. Towards this end we present a comparative analysis of the nucleotide sequences of the numerous plasmids of B. burgdorferi isolates B31, N40, JD1 and 297. These strains were chosen because they include the three most commonly studied laboratory strains, and because they represent different major genetic lineages and so are informative regarding the genetic diversity and evolution of this organism. A unique feature of Borrelia genomes is that they carry a large number of linear and circular plasmids, and this work shows that strains N40, JD1, 297 and B31 carry related but non-identical sets of 16, 20, 19 and 21 plasmids, respectively, that comprise 33-40% of their genomes. We deduce that there are at least 28 plasmid compatibility types among the four strains. The B. burgdorferi ,900 Kbp linear chromosomes are evolutionarily exceptionally stable, except for a short „20 Kbp plasmid-like section at the right end. A few of the plasmids, including the linear lp54 and circular cp26, are also very stable. We show here that the other plasmids, especially the linear ones, are considerably more variable. Nearly all of the linear plasmids have undergone one or more substantial inter-plasmid rearrangements since their last common ancestor. In spite of these rearrangements and differences in plasmid contents, the overall gene complement of the different isolates has remained relatively constant. [ABSTRACT FROM AUTHOR]

Published
2012
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38. How genomics has affected the concept of microbiology

Author

Ward, Naomi and Fraser, Claire M

Subjects
*GENOMICS, *MOLECULAR genetics, *MICROBIOLOGY, *BIOCHEMISTRY, *BACTERIAL metabolism, *GENOMES, *GENETIC research
Abstract

Genomics influences multiple areas of microbiology, and thus affects key microbiological concepts. Recent reports that describe the large genome and unusual coding capacity of mimivirus, the minimized fungal genomes that contain elements of bacterial metabolism, and the ‘signature’ eukaryotic proteins in bacteria are introducing grey shades into the black-and-white distinctions between microbial domains. The concept of the ‘universal’ minimal genome is being challenged, and the ability of minimal genomes to support cellular complexity is under investigation. There have been intriguing insights into microbe–microbe relationships, for example conflict mediation in competing bacteriophages that rapidly evolve survival mechanisms when cooperation is experimentally enforced. Genomics has given birth to metagenomics, but has also stimulated the development of improved cultivation techniques. Lastly, the taxonomic potential of genomics is emerging, as studies of multiple strains allow us to revise and refine the bacterial species concept as well as the idea of a static genome. [Copyright &y& Elsevier]

Published
2005
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39. Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses.

Author

Holmes, Edward C., Ghedin, Elodie, Miller, Naomi, Taylor, Jill, Yiming Bao, St. George, Kirsten, Grenfell, Bryan T., Salzberg, Steven L., Fraser, Claire M., Lipman, David J., and Taubenberger, Jeffery K.

Subjects
INFLUENZA viruses, GENOMES, INFLUENZA vaccines, PHYLOGENY, HEMAGGLUTININ
Abstract

Understanding the evolution of influenza A viruses in humans is important for surveillance and vaccine strain selection. We performed a phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States, and observed multiple co-circulating clades with different population frequencies. Strikingly, phylogenies inferred for individual gene segments revealed that multiple reassortment events had occurred among these clades, such that one clade of H3N2 viruses present at least since 2000 had provided the hemagglutinin gene for all those H3N2 viruses sampled after the 2002-2003 influenza season. This reassortment event was the likely progenitor of the antigenically variant influenza strains that caused the A/Fujian/411/2002-like epidemic of the 2003-2004 influenza season. However, despite sharing the same hemagglutinin, these phylogenetically distinct lineages of viruses continue to co-circulate in the same population. These data, derived from the first large-scale analysis of H3N2 viruses, convincingly demonstrate that multiple lineages can co-circulate, persist, and reassort in epidemiologically significant ways, and underscore the importance of genomic analyses for future influenza surveillance. [ABSTRACT FROM AUTHOR]

Published
2005
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40. APPLICATION OF MICROBIAL GENOMIC SCIENCE TO ADVANCED THERAPEUTICS.

Author

Fraser, Claire M. and Rappuoli, Rino

Subjects
*GENOMES, *GENETIC polymorphisms, *PREVENTIVE medicine, *MOLECULAR biology, *CLINICAL medicine, *DISEASES
Abstract

Since the publication of the first complete microbial genome sequence of Haemophilus influenzae in 1995, more than 200 additional microbial genome se- quences have become available in the public domain. Approximately 40% of these represent important human pathogens. Comparative in silico methods, along with large-scale approaches such as transcriptomics and proteomics, are beginning to reveal insights into new virulence genes, pathogen-host interactions, and the molecular basis of host specificity. Sequence data are also starting to accumulate from multiple isolates or strains of a single pathogen, and this type of data has proven to be quite valuable in providing new insights into the genetic variability that is present in a particular species as well as in facilitating correlations between genotype and phenotype. Ultimately, a major goal of genome-enabled infectious disease research is the development of novel diagnostics, therapeutics, and vaccines. [ABSTRACT FROM AUTHOR]

Published
2005
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41. Major Structural Differences and Novel Potential Virulence Mechanisms from the Genomes of Multiple Campylobacter Species.

Author

Fouts, Derrick E, Mongodin, Emmanuel F, Mandrell, Robert E, Miller, William G, Rasko, David A, Ravel, Jacques, Brinkac, Lauren M, DeBoy, Robert T, Parker, Craig T, Daugherty, Sean C, Dodson, Robert J, Durkin, A. Scott, Madupu, Ramana, Sullivan, Steven A, Shetty, Jyoti U, Ayodeji, Mobolanle A, Shvartsbeyn, Alla, Schatz, Michael C, Badger, Jonathan H, and Fraser, Claire M

Subjects
CAMPYLOBACTER, CAMPYLOBACTER jejuni, SPECIES, COLONIZATION (Ecology), MEMBRANE proteins, GENOMES, COMPARATIVE genomics
Abstract

Sequencing and comparative genome analysis of four strains of Campylobacter including C. lari RM2100, C. upsaliensis RM3195, and C. coli RM2228 has revealed major structural differences that are associated with the insertion of phage- and plasmid-like genomic islands, as well as major variations in the lipooligosaccharide complex. Poly G tracts are longer, are greater in number, and show greater variability in C. upsaliensis than in the other species. Many genes involved in host colonization, including racR/S, cadF, cdt, ciaB, and flagellin genes, are conserved across the species, but variations that appear to be species specific are evident for a lipooligosaccharide locus, a capsular (extracellular) polysaccharide locus, and a novel Campylobacter putative licABCD virulence locus. The strains also vary in their metabolic profiles, as well as their resistance profiles to a range of antibiotics. It is evident that the newly identified hypothetical and conserved hypothetical proteins, as well as uncharacterized two-component regulatory systems and membrane proteins, may hold additional significant information on the major differences in virulence among the species, as well as the specificity of the strains for particular hosts. Although the single genome sequence of the human Campylobacter jejuni yielded some insight, comparison of multiple species of the same genus elucidated greater understanding of virulence mechanisms. [ABSTRACT FROM AUTHOR]

Published
2005
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42. An integrated 4249 marker FISH/RH map of the canine genome.

Author

Breen, Matthew, Hitte, Christophe, Lorentzen, Travis D., Thomas, Rachael, Cadieu, Edouard, Sabacan, Leah, Scott, Allyson, Evanno, Gwenaelle, Parker, Heidi G., Kirkness, Ewen F., Hudson, Ruth, Guyon, Richard, Mahairas, Gregory G., Gelfenbeyn, Boris, Fraser, Claire M., André, Catherine, Galibert, Francis, and Ostrander, Elaine A.

Subjects
DOGS, GENOMES, GENES, BIOLOGICAL variation, GENETICS, BACTERIAL artificial chromosomes, HUMAN gene mapping
Abstract

Background: The 156 breeds of dog recognized by the American Kennel Club offer a unique opportunity to map genes important in genetic variation. Each breed features a defining constellation of morphological and behavioral traits, often generated by deliberate crossing of closely related individuals, leading to a high rate of genetic disease in many breeds. Understanding the genetic basis of both phenotypic variation and disease susceptibility in the dog provides new ways in which to dissect the genetics of human health and biology. Results: To facilitate both genetic mapping and cloning efforts, we have constructed an integrated canine genome map that is both dense and accurate. The resulting resource encompasses 4249 markers, and was constructed using the RHDF5000-2 whole genome radiation hybrid panel. The radiation hybrid (RH) map features a density of one marker every 900 Kb and contains 1760 bacterial artificial chromosome clones (BACs) localized to 1423 unique positions, 851 of which have also been mapped by fluorescence in situ hybridization (FISH). The two data sets show excellent concordance. Excluding the Y chromosome, the map features an RH/FISH mapped BAC every 3.5 Mb and an RH mapped BAC-end, on average, every 2 Mb. For 2233 markers, the orthologous human genes have been established, allowing the identification of 79 conserved segments (CS) between the dog and human genomes, dramatically extending the length of most previously described CS. Conclusions: These results provide a necessary resource for the canine genome mapping community to undertake positional cloning experiments and provide new insights into the comparative canine-human genome maps. [ABSTRACT FROM AUTHOR]

Published
2004
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43. Comparative Genomics and Understanding of Microbial Biology.

Author

Fraser, Claire M., Eisen, Jonathan, Fleischmann, Robert D., Ketchum, Karen A., and Peterson, Scott

Subjects
*GENOMES, *MICROBIOLOGY
Abstract

The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences. [ABSTRACT FROM AUTHOR]

Published
2000
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44. Microbial genome sequencing.

Author

Fraser, Claire M., Eisen, Jonathan A., and Salzberg, Steven L.

Subjects
*MICROBIAL genetics, *GENOMES, *GENES, *ANTI-infective agents, *ANALYTICAL chemistry, *IDENTIFICATION
Abstract

Discusses the sequencing of the genomes of microbial species. Methods for whole-genome analysis; Identification of microbial genes; Physiological and evolutionary findings associated with genome analysis; Implications for the development of novel antimicrobial agents and vaccines.

Published
2000
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45. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.

Author

Fraser, Claire M. and Casjens, Sherwood

Subjects
*GENETIC code, *GENOMES, *LYME disease, *GENETICS
Abstract

Presents research which described the genomic sequence of the bacterium Borrelia burgdorferi, the etiologic agent of Lyme disease. Genome's linear chromosome; Chromosome's genes; Relationship to Mycoplasma genitalium; Plasmid genes; Unclear biological significance of plasmid genes.

Published
1997
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46. Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation.

Author

Zhao, Shaying, Shetty, Jyoti, Hou, Lihua, Delcher, Arthur, Zhu, Baoli, Osoegawa, Kazutoyo, de Jong, Pieter, Nierman, William C., Strausberg, Robert L., and Fraser, Claire M.

Subjects
*HUMAN genome, *NUCLEOTIDE sequence, *GENOMICS, *GENOMES, *GENETICS, *CHROMOSOMES
Abstract

Using paired-end sequences from bacterial artificial chromosomes, we have constructed high-resolution synteny and rearrangement breakpoint maps among human, mouse, and rat genomes. Among the >300 syntenic blocks identified are segments of over 40 Mb without any detected interspecies rearrangements, as well as regions with frequently broken synteny and extensive rearrangements. As closely related species, mouse and rat share the majority of the breakpoints and often have the same types of rearrangements when compared with the human genome. However, the breakpoints not shared between them indicate that mouse rearrangements are more often interchromosomal, whereas intrachromosomal rearrangements are more prominent in rat. Centromeres may have played a significant role in reorganizing a number of chromosomes in all three species. The comparison of the three species indicates that genome rearrangements follow a path that accommodates a delicate balance between maintaining a basic structure underlying all mammalian species and permitting variations that are necessary for speciation. [ABSTRACT FROM AUTHOR]

Published
2004
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47. Gene synteny and evolution of genome architecture in trypanosomatids

Author

Ghedin, Elodie, Bringaud, Frederic, Peterson, Jeremy, Myler, Peter, Berriman, Matthew, Ivens, Alasdair, Andersson, Björn, Bontempi, Esteban, Eisen, Jonathan, Angiuoli, Sam, Wanless, David, Von Arx, Anna, Murphy, Lee, Lennard, Nicola, Salzberg, Steven, Adams, Mark D., White, Owen, Hall, Neil, Stuart, Kenneth, and Fraser, Claire M.

Subjects
*TRYPANOSOMATIDAE, *PATHOGENIC microorganisms, *GENOMES, *ANGIOTENSIN converting enzyme, *HUMAN beings
Abstract

The trypanosomatid protozoa Trypanosoma brucei, Trypanosoma cruzi and Leishmania major are related human pathogens that cause markedly distinct diseases. Using information from genome sequencing projects currently underway, we have compared the sequences of large chromosomal fragments from each species. Despite high levels of divergence at the sequence level, these three species exhibit a striking conservation of gene order, suggesting that selection has maintained gene order among the trypanosomatids over hundreds of millions of years of evolution. The few sites of genome rearrangement between these species are marked by the presence of retrotransposon-like elements, suggesting that retrotransposons may have played an important role in shaping trypanosomatid genome organization. A degenerate retroelement was identified in L. major by examining the regions near breakage points of the synteny. This is the first such element found in L. major suggesting that retroelements were found in the common ancestor of all three species. [Copyright &y& Elsevier]

Published
2004
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