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Your search keyword '"Li, Shengchao A."' showing total 4 results
Start Over Author "Li, Shengchao A." Topic genome-wide association studies
4 results on '"Li, Shengchao A."'

1. A saturated map of common genetic variants associated with human height

Author

Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U, Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D, Graham, Sarah E, Mukamel, Ronen E, Spracklen, Cassandra N, Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H, Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E, Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S, Akiyama, Masato, Allison, Matthew A, Alvarez, Marcus, Andersen, Mette K, Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F, Bollepalli, Sailalitha, Bonnycastle, Lori L, Bork-Jensen, Jette, Bradfield, Jonathan P, Bradford, Yuki, Braund, Peter S, Brody, Jennifer A, Burgdorf, Kristoffer S, Cade, Brian E, Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, Chang, Yi-Cheng, Chen, Chien-Hsiun, Chesi, Alessandra, Choi, Seung Hoan, Chung, Ren-Hua, Cocca, Massimiliano, Concas, Maria Pina, Couture, Christian, Cuellar-Partida, Gabriel, Danning, Rebecca, Daw, E Warwick, Degenhard, Frauke, Delgado, Graciela E, Delitala, Alessandro, Demirkan, Ayse, Deng, Xuan, Devineni, Poornima, Dietl, Alexander, Dimitriou, Maria, Dimitrov, Latchezar, Dorajoo, Rajkumar, Ekici, Arif B, Engmann, Jorgen E, Fairhurst-Hunter, Zammy, Farmaki, Aliki-Eleni, Faul, Jessica D, Fernandez-Lopez, Juan-Carlos, Forer, Lukas, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian, Galesloot, Tessel E, Gao, Yan, Gao, Zishan, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette P, Goel, Anuj, Gordon, Scott D, Gorski, Mathias, Grove, Jakob, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeffrey, Hansen, Thomas F, Havulinna, Aki S, Haworth, Simon J, He, Jing, Heard-Costa, Nancy, Hebbar, Prashantha, Hindy, George, Ho, Yuk-Lam A, Hofer, Edith, Holliday, Elizabeth, Horn, Katrin, Hornsby, Whitney E, Hottenga, Jouke-Jan, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia, Huffman, Jennifer E, Hung, Yi-Jen, Huo, Shaofeng, Hwang, Mi Yeong, Iha, Hiroyuki, Ikeda, Daisuke D, Isono, Masato, Jackson, Anne U, Jäger, Susanne, Jansen, Iris E, Johansson, Ingegerd, Jonas, Jost B, Jonsson, Anna, Jørgensen, Torben, Kalafati, Ioanna-Panagiota, Kanai, Masahiro, Kanoni, Stavroula, Kårhus, Line L, Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kawaguchi, Takahisa, Kember, Rachel L, Kentistou, Katherine A, Kim, Han-Na, Kim, Young Jin, Kleber, Marcus E, Knol, Maria J, Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney, Lee, Jong-Young, Leonard, Hampton L, Li, Shengchao A, Li, Xiaohui, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shih-Yi, Liu, Jun, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian'an, Lyssenko, Valeriya, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Mattheisen, Manuel, Mavarani, Laven, McDaid, Aaron F, Meidtner, Karina, Melendez, Tori L, Mercader, Josep M, Milaneschi, Yuri, Miller, Jason E, Millwood, Iona Y, Mishra, Pashupati P, Mitchell, Ruth E, Møllehave, Line T, Morgan, Anna, Mucha, Soeren, Munz, Matthias, Nakatochi, Masahiro, Nelson, Christopher P, Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A, Nolte, Ilja M, Nongmaithem, Suraj S, Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva RB, Petersen, Liselotte V, Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H, Pyarajan, Saiju, Raffield, Laura M, Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W, Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E, Ryan, Kathleen A, Sabater-Lleal, Maria, Saxena, Richa, Scholz, Markus, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M, Slieker, Roderick C, Smit, Roelof AJ, Smith, Albert V, Smith, Jennifer A, Smyth, Laura J, Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent D, Tayo, Bamidele O, Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola, Teumer, Alexander, Theusch, Elizabeth, Thompson, Deborah J, Thorleifsson, Gudmar, Timmers, Paul RHJ, Trompet, Stella, Turman, Constance, Vaccargiu, Simona, Van Der Laan, Sander W, Van Der Most, Peter J, Van Klinken, Jan B, Van Setten, Jessica, Verma, Shefali S, Verweij, Niek, Veturi, Yogasudha, Wang, Carol A, Wang, Chaolong, Wang, Lihua, Wang, Zhe, Warren, Helen R, Bin Wei, Wen, Wickremasinghe, Ananda R, Wielscher, Matthias, Wiggins, Kerri L, Winsvold, Bendik S, Wong, Andrew, Wu, Yang, Wuttke, Matthias, Xia, Rui, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah, Yousri, Noha A, Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jing-Hua, Zhao, Wei, Zhou, Wei, Zimmermann, Martina E, Zoledziewska, Magdalena, Adair, Linda S, Adams, Hieab HH, Aguilar-Salinas, Carlos A, Al-Mulla, Fahd, Arnett, Donna K, Asselbergs, Folkert W, Åsvold, Bjørn Olav, Attia, John, Banas, Bernhard, Bandinelli, Stefania, Bennett, David A, Bergler, Tobias, Bharadwaj, Dwaipayan, Biino, Ginevra, Bisgaard, Hans, Boerwinkle, Eric, Böger, Carsten A, Bønnelykke, Klaus, Boomsma, Dorret I, Børglum, Anders D, Borja, Judith B, Bouchard, Claude, Bowden, Donald W, Brandslund, Ivan, Brumpton, Ben, Buring, Julie E, Caulfield, Mark J, Chambers, John C, Chandak, Giriraj R, Chanock, Stephen J, Chaturvedi, Nish, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Ching-Yu, Christophersen, Ingrid E, Ciullo, Marina, Cole, John W, Collins, Francis S, Cooper, Richard S, Cruz, Miguel, Cucca, Francesco, Cupples, L Adrienne, Cutler, Michael J, Damrauer, Scott M, Dantoft, Thomas M, De Borst, Gert J, De Groot, Lisette CPGM, De Jager, Philip L, De Kleijn, Dominique PV, Janaka De Silva, H, Dedoussis, George V, Den Hollander, Anneke I, Du, Shufa, Easton, Douglas F, Elders, Petra JM, Eliassen, A Heather, Ellinor, Patrick T, Elmståhl, Sölve, Erdmann, Jeanette, Evans, Michele K, Fatkin, Diane, Feenstra, Bjarke, Feitosa, Mary F, Ferrucci, Luigi, Ford, Ian, Fornage, Myriam, Franke, Andre, Franks, Paul W, Freedman, Barry I, Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Goddard, Michael E, Golightly, Yvonne M, Gonzalez-Villalpando, Clicerio, Gordon-Larsen, Penny, Grallert, Harald, Grant, Struan FA, Grarup, Niels, Griffiths, Lyn, Gudnason, Vilmundur, Haiman, Christopher, Hakonarson, Hakon, Hansen, Torben, Hartman, Catharina A, Hattersley, Andrew T, Hayward, Caroline, Heckbert, Susan R, Heng, Chew-Kiat, Hengstenberg, Christian, Hewitt, Alex W, Hishigaki, Haretsugu, Hoyng, Carel B, Huang, Paul L, Huang, Wei, Hunt, Steven C, Hveem, Kristian, Hyppönen, Elina, Iacono, William G, Ichihara, Sahoko, Ikram, M Arfan, Isasi, Carmen R, Jackson, Rebecca D, Jarvelin, Marjo-Riitta, Jin, Zi-Bing, Jöckel, Karl-Heinz, Joshi, Peter K, Jousilahti, Pekka, Jukema, J Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kang, Kui Dong, Kaprio, Jaakko, Kardia, Sharon LR, Karpe, Fredrik, Kato, Norihiro, Kee, Frank, Kessler, Thorsten, Khera, Amit V, Khor, Chiea Chuen, Kiemeney, Lambertus ALM, Kim, Bong-Jo, Kim, Eung Kweon, Kim, Hyung-Lae, Kirchhof, Paulus, Kivimaki, Mika, Koh, Woon-Puay, Koistinen, Heikki A, Kolovou, Genovefa D, Kooner, Jaspal S, Kooperberg, Charles, Köttgen, Anna, Kovacs, Peter, Kraaijeveld, Adriaan, Kraft, Peter, Krauss, Ronald M, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lange, Leslie A, Langenberg, Claudia, Launer, Lenore J, Le Marchand, Loic, Lee, Hyejin, Lee, Nanette R, Lehtimäki, Terho, Li, Huaixing, Li, Liming, Lieb, Wolfgang, Lin, Xu, Lind, Lars, Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Loeffler, Markus, London, Barry, Lubitz, Steven A, Lye, Stephen J, Mackey, David A, Mägi, Reedik, Magnusson, Patrik KE, Marcus, Gregory M, Vidal, Pedro Marques, Martin, Nicholas G, März, Winfried, Matsuda, Fumihiko, McGarrah, Robert W, McGue, Matt, McKnight, Amy Jayne, Medland, Sarah E, Mellström, Dan, Metspalu, Andres, Mitchell, Braxton D, Mitchell, Paul, Mook-Kanamori, Dennis O, Morris, Andrew D, Mucci, Lorelei A, Munroe, Patricia B, Nalls, Mike A, Nazarian, Saman, Nelson, Amanda E, Neville, Matt J, Newton-Cheh, Christopher, Nielsen, Christopher S, Nöthen, Markus M, Ohlsson, Claes, Oldehinkel, Albertine J, Orozco, Lorena, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin NA, Parra, Esteban J, Pattaro, Cristian, Pedersen, Oluf, Pennell, Craig E, Penninx, Brenda WJH, Perusse, Louis, Peters, Annette, Peyser, Patricia A, Porteous, David J, Posthuma, Danielle, Power, Chris, Pramstaller, Peter P, Province, Michael A, Qi, Qibin, Qu, Jia, Rader, Daniel J, Raitakari, Olli T, Ralhan, Sarju, Rallidis, Loukianos S, Rao, Dabeeru C, Redline, Susan, Reilly, Dermot F, Reiner, Alexander P, Rhee, Sang Youl, Ridker, Paul M, Rienstra, Michiel, Ripatti, Samuli, Ritchie, Marylyn D, Roden, Dan M, Rosendaal, Frits R, Rotter, Jerome I, Rudan, Igor, Rutters, Femke, Sabanayagam, Charumathi, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Börge, Schmidt, Helena, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Laura J, Scott, Rodney J, Sever, Peter, Shiroma, Eric J, Shoemaker, M Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M, Sims, Mario, Singh, Jai Rup, Singleton, Andrew B, Sinner, Moritz F, Smith, J Gustav, Snieder, Harold, Spector, Tim D, Stampfer, Meir J, Stark, Klaus J, Strachan, David P, 'T Hart, Leen M, Tabara, Yasuharu, Tang, Hua, Tardif, Jean-Claude, Thanaraj, Thangavel A, Timpson, Nicholas J, Tönjes, Anke, Tremblay, Angelo, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Maria-Teresa, Uitterlinden, Andre G, Van Dam, Rob M, Van Der Harst, Pim, Van Der Velde, Nathalie, Van Duijn, Cornelia M, Van Schoor, Natasja M, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wacher-Rodarte, Niels H, Walker, Mark, Wang, Ya Xing, Wareham, Nicholas J, Watanabe, Richard M, Watkins, Hugh, Weir, David R, Werge, Thomas M, Widen, Elisabeth, Wilkens, Lynne R, Willemsen, Gonneke, Willett, Walter C, Wilson, James F, Wong, Tien-Yin, Woo, Jeong-Taek, Wright, Alan F, Wu, Jer-Yuarn, Xu, Huichun, Yajnik, Chittaranjan S, Yokota, Mitsuhiro, Yuan, Jian-Min, Zeggini, Eleftheria, Zemel, Babette S, Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M, Zonderman, Alan B, Zwart, John-Anker, 23andMe Research Team, VA Million Veteran Program, DiscovEHR (DiscovEHR And MyCode Community Health Initiative), EMERGE (Electronic Medical Records And Genomics Network), Lifelines Cohort Study, PRACTICAL Consortium, Understanding Society Scientific Group, Chasman, Daniel I, Cho, Yoon Shin, Heid, Iris M, McCarthy, Mark I, Ng, Maggie CY, O'Donnell, Christopher J, Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Sun, Yan V, Tai, E Shyong, Boehnke, Michael, Deloukas, Panos, Justice, Anne E, Lindgren, Cecilia M, Loos, Ruth JF, Mohlke, Karen L, North, Kari E, Stefansson, Kari, Walters, Robin G, Winkler, Thomas W, Young, Kristin L, Loh, Po-Ru, Yang, Jian, Esko, Tõnu, Assimes, Themistocles L, Auton, Adam, Abecasis, Goncalo R, Willer, Cristen J, Locke, Adam E, Berndt, Sonja I, Lettre, Guillaume, Frayling, Timothy M, Okada, Yukinori, Wood, Andrew R, Visscher, Peter M, Hirschhorn, Joel N, Oral Implantology, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Liability Law, Earth Sciences, Amsterdam Reproduction & Development, APH - Mental Health, APH - Methodology, Environmental Geography (former), Art and Culture, History, Antiquity, Sociology and Social Gerontology, Complex Trait Genetics, Amsterdam Neuroscience - Complex Trait Genetics, Nutrition and Health, Organic Chemistry, AIMMS, Life Course Epidemiology (LCE), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Cardiovascular Centre (CVC), Internal Medicine, Epidemiology, Radiology & Nuclear Medicine, Clinical Genetics, Team, 23andMe Research, Program, VA Million Veteran, Initiative), DiscovEHR (DiscovEHR and 112 MyCode Community Health, Network), eMERGE (Electronic Medical Records and Genomics, Study, Lifelines Cohort, Consortium, The PRACTICAL, Group, Understanding Society Scientific, Yengo, Loïc [0000-0002-4272-9305], Apollo - University of Cambridge Repository, Laboratory Genetic Metabolic Diseases, Laboratory for General Clinical Chemistry, Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Heart failure & arrhythmias, Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, General practice, ACS - Diabetes & metabolism, Human genetics, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Reproduction & Development (AR&D), Epidemiology and Data Science, Internal medicine, APH - Digital Health, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Hypponen, Elina, Hirschhorn, Joel N, Epigenetics of Complex Diseases and Traits, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Joint Activities, University of Helsinki, Medicum, Complex Disease Genetics, Samuli Olli Ripatti / Principal Investigator, Helsinki Institute of Life Science HiLIFE, Department of Medicine, HUS Internal Medicine and Rehabilitation, Clinicum, Centre of Excellence in Complex Disease Genetics, Department of Public Health, Faculty Common Matters (Faculty of Social Sciences), Research Programs Unit, HUS Abdominal Center, Tiinamaija Tuomi Research Group, CAMM - Research Program for Clinical and Molecular Metabolism, Departments of Faculty of Veterinary Medicine, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation, 23andMe Research Team, VA Million Veteran Program, DiscovEHR (DiscovEHR and MyCode Community Health Initiative), eMERGE (Electronic Medical Records and Genomics Network), Lifelines Cohort Study, PRACTICAL Consortium, Understanding Society Scientific Group, Partida, G.C., Sun, Y., Croteau-Chonka, D., Vonk, J.M., Chanock, S., Le Marchand, L., Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U, Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D, Graham, Sarah E, Mukamel, Ronen E, Spracklen, Cassandra N, Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H, Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E, Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S, Akiyama, Masato, Allison, Matthew A, Alvarez, Marcu, Andersen, Mette K, Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F, Bollepalli, Sailalitha, Bonnycastle, Lori L, Bork-Jensen, Jette, Bradfield, Jonathan P, Bradford, Yuki, Braund, Peter S, Brody, Jennifer A, Burgdorf, Kristoffer S, Cade, Brian E, Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, Chang, Yi-Cheng, Chen, Chien-Hsiun, Chesi, Alessandra, Choi, Seung Hoan, Chung, Ren-Hua, Cocca, Massimiliano, Concas, Maria Pina, Couture, Christian, Cuellar-Partida, Gabriel, Danning, Rebecca, Daw, E Warwick, Degenhard, Frauke, Delgado, Graciela E, Delitala, Alessandro, Demirkan, Ayse, Deng, Xuan, Devineni, Poornima, Dietl, Alexander, Dimitriou, Maria, Dimitrov, Latchezar, Dorajoo, Rajkumar, Ekici, Arif B, Engmann, Jorgen E, Fairhurst-Hunter, Zammy, Farmaki, Aliki-Eleni, Faul, Jessica D, Fernandez-Lopez, Juan-Carlo, Forer, Luka, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian, Galesloot, Tessel E, Gao, Yan, Gao, Zishan, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette P, Goel, Anuj, Gordon, Scott D, Gorski, Mathia, Grove, Jakob, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeffrey, Hansen, Thomas F, Havulinna, Aki S, Haworth, Simon J, He, Jing, Heard-Costa, Nancy, Hebbar, Prashantha, Hindy, George, Ho, Yuk-Lam A, Hofer, Edith, Holliday, Elizabeth, Horn, Katrin, Hornsby, Whitney E, Hottenga, Jouke-Jan, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia, Huffman, Jennifer E, Hung, Yi-Jen, Huo, Shaofeng, Hwang, Mi Yeong, Iha, Hiroyuki, Ikeda, Daisuke D, Isono, Masato, Jackson, Anne U, Jäger, Susanne, Jansen, Iris E, Johansson, Ingegerd, Jonas, Jost B, Jonsson, Anna, Jørgensen, Torben, Kalafati, Ioanna-Panagiota, Kanai, Masahiro, Kanoni, Stavroula, Kårhus, Line L, Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kawaguchi, Takahisa, Kember, Rachel L, Kentistou, Katherine A, Kim, Han-Na, Kim, Young Jin, Kleber, Marcus E, Knol, Maria J, Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney, Lee, Jong-Young, Leonard, Hampton L, Li, Shengchao A, Li, Xiaohui, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shih-Yi, Liu, Jun, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian'An, Lyssenko, Valeriya, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Mattheisen, Manuel, Mavarani, Laven, Mcdaid, Aaron F, Meidtner, Karina, Melendez, Tori L, Mercader, Josep M, Milaneschi, Yuri, Miller, Jason E, Millwood, Iona Y, Mishra, Pashupati P, Mitchell, Ruth E, Møllehave, Line T, Morgan, Anna, Mucha, Soeren, Munz, Matthia, Nakatochi, Masahiro, Nelson, Christopher P, Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A, Nolte, Ilja M, Nongmaithem, Suraj S, Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva R B, Petersen, Liselotte V, Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H, Pyarajan, Saiju, Raffield, Laura M, Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Denni, Rayner, Nigel W, Riveros, Carlo, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E, Ryan, Kathleen A, Sabater-Lleal, Maria, Saxena, Richa, Scholz, Marku, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M, Slieker, Roderick C, Smit, Roelof A J, Smith, Albert V, Smith, Jennifer A, Smyth, Laura J, Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent D, Tayo, Bamidele O, Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola, Teumer, Alexander, Theusch, Elizabeth, Thompson, Deborah J, Thorleifsson, Gudmar, Timmers, Paul R H J, Trompet, Stella, Turman, Constance, Vaccargiu, Simona, van der Laan, Sander W, van der Most, Peter J, van Klinken, Jan B, van Setten, Jessica, Verma, Shefali S, Verweij, Niek, Veturi, Yogasudha, Wang, Carol A, Wang, Chaolong, Wang, Lihua, Wang, Zhe, Warren, Helen R, Bin Wei, Wen, Wickremasinghe, Ananda R, Wielscher, Matthia, Wiggins, Kerri L, Winsvold, Bendik S, Wong, Andrew, Wu, Yang, Wuttke, Matthia, Xia, Rui, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah, Yousri, Noha A, Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jing-Hua, Zhao, Wei, Zhou, Wei, Zimmermann, Martina E, Zoledziewska, Magdalena, Adair, Linda S, Adams, Hieab H H, Aguilar-Salinas, Carlos A, Al-Mulla, Fahd, Arnett, Donna K, Asselbergs, Folkert W, Åsvold, Bjørn Olav, Attia, John, Banas, Bernhard, Bandinelli, Stefania, Bennett, David A, Bergler, Tobia, Bharadwaj, Dwaipayan, Biino, Ginevra, Bisgaard, Han, Boerwinkle, Eric, Böger, Carsten A, Bønnelykke, Klau, Boomsma, Dorret I, Børglum, Anders D, Borja, Judith B, Bouchard, Claude, Bowden, Donald W, Brandslund, Ivan, Brumpton, Ben, Buring, Julie E, Caulfield, Mark J, Chambers, John C, Chandak, Giriraj R, Chanock, Stephen J, Chaturvedi, Nish, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Ching-Yu, Christophersen, Ingrid E, Ciullo, Marina, Cole, John W, Collins, Francis S, Cooper, Richard S, Cruz, Miguel, Cucca, Francesco, Cupples, L Adrienne, Cutler, Michael J, Damrauer, Scott M, Dantoft, Thomas M, de Borst, Gert J, de Groot, Lisette C P G M, De Jager, Philip L, de Kleijn, Dominique P V, Janaka de Silva, H, Dedoussis, George V, den Hollander, Anneke I, Du, Shufa, Easton, Douglas F, Elders, Petra J M, Eliassen, A Heather, Ellinor, Patrick T, Elmståhl, Sölve, Erdmann, Jeanette, Evans, Michele K, Fatkin, Diane, Feenstra, Bjarke, Feitosa, Mary F, Ferrucci, Luigi, Ford, Ian, Fornage, Myriam, Franke, Andre, Franks, Paul W, Freedman, Barry I, Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Goddard, Michael E, Golightly, Yvonne M, Gonzalez-Villalpando, Clicerio, Gordon-Larsen, Penny, Grallert, Harald, Grant, Struan F A, Grarup, Niel, Griffiths, Lyn, Gudnason, Vilmundur, Haiman, Christopher, Hakonarson, Hakon, Hansen, Torben, Hartman, Catharina A, Hattersley, Andrew T, Hayward, Caroline, Heckbert, Susan R, Heng, Chew-Kiat, Hengstenberg, Christian, Hewitt, Alex W, Hishigaki, Haretsugu, Hoyng, Carel B, Huang, Paul L, Huang, Wei, Hunt, Steven C, Hveem, Kristian, Hyppönen, Elina, Iacono, William G, Ichihara, Sahoko, Ikram, M Arfan, Isasi, Carmen R, Jackson, Rebecca D, Jarvelin, Marjo-Riitta, Jin, Zi-Bing, Jöckel, Karl-Heinz, Joshi, Peter K, Jousilahti, Pekka, Jukema, J Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kang, Kui Dong, Kaprio, Jaakko, Kardia, Sharon L R, Karpe, Fredrik, Kato, Norihiro, Kee, Frank, Kessler, Thorsten, Khera, Amit V, Khor, Chiea Chuen, Kiemeney, Lambertus A L M, Kim, Bong-Jo, Kim, Eung Kweon, Kim, Hyung-Lae, Kirchhof, Paulu, Kivimaki, Mika, Koh, Woon-Puay, Koistinen, Heikki A, Kolovou, Genovefa D, Kooner, Jaspal S, Kooperberg, Charle, Köttgen, Anna, Kovacs, Peter, Kraaijeveld, Adriaan, Kraft, Peter, Krauss, Ronald M, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lange, Leslie A, Langenberg, Claudia, Launer, Lenore J, Le Marchand, Loic, Lee, Hyejin, Lee, Nanette R, Lehtimäki, Terho, Li, Huaixing, Li, Liming, Lieb, Wolfgang, Lin, Xu, Lind, Lar, Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Loeffler, Marku, London, Barry, Lubitz, Steven A, Lye, Stephen J, Mackey, David A, Mägi, Reedik, Magnusson, Patrik K E, Marcus, Gregory M, Vidal, Pedro Marque, Martin, Nicholas G, März, Winfried, Matsuda, Fumihiko, Mcgarrah, Robert W, Mcgue, Matt, Mcknight, Amy Jayne, Medland, Sarah E, Mellström, Dan, Metspalu, Andre, Mitchell, Braxton D, Mitchell, Paul, Mook-Kanamori, Dennis O, Morris, Andrew D, Mucci, Lorelei A, Munroe, Patricia B, Nalls, Mike A, Nazarian, Saman, Nelson, Amanda E, Neville, Matt J, Newton-Cheh, Christopher, Nielsen, Christopher S, Nöthen, Markus M, Ohlsson, Clae, Oldehinkel, Albertine J, Orozco, Lorena, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin N A, Parra, Esteban J, Pattaro, Cristian, Pedersen, Oluf, Pennell, Craig E, Penninx, Brenda W J H, Perusse, Loui, Peters, Annette, Peyser, Patricia A, Porteous, David J, Posthuma, Danielle, Power, Chri, Pramstaller, Peter P, Province, Michael A, Qi, Qibin, Qu, Jia, Rader, Daniel J, Raitakari, Olli T, Ralhan, Sarju, Rallidis, Loukianos S, Rao, Dabeeru C, Redline, Susan, Reilly, Dermot F, Reiner, Alexander P, Rhee, Sang Youl, Ridker, Paul M, Rienstra, Michiel, Ripatti, Samuli, Ritchie, Marylyn D, Roden, Dan M, Rosendaal, Frits R, Rotter, Jerome I, Rudan, Igor, Rutters, Femke, Sabanayagam, Charumathi, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Börge, Schmidt, Helena, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Laura J, Scott, Rodney J, Sever, Peter, Shiroma, Eric J, Shoemaker, M Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M, Sims, Mario, Singh, Jai Rup, Singleton, Andrew B, Sinner, Moritz F, Smith, J Gustav, Snieder, Harold, Spector, Tim D, Stampfer, Meir J, Stark, Klaus J, Strachan, David P, 't Hart, Leen M, Tabara, Yasuharu, Tang, Hua, Tardif, Jean-Claude, Thanaraj, Thangavel A, Timpson, Nicholas J, Tönjes, Anke, Tremblay, Angelo, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Maria-Teresa, Uitterlinden, Andre G, van Dam, Rob M, van der Harst, Pim, Van der Velde, Nathalie, van Duijn, Cornelia M, van Schoor, Natasja M, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wacher-Rodarte, Niels H, Walker, Mark, Wang, Ya Xing, Wareham, Nicholas J, Watanabe, Richard M, Watkins, Hugh, Weir, David R, Werge, Thomas M, Widen, Elisabeth, Wilkens, Lynne R, Willemsen, Gonneke, Willett, Walter C, Wilson, James F, Wong, Tien-Yin, Woo, Jeong-Taek, Wright, Alan F, Wu, Jer-Yuarn, Xu, Huichun, Yajnik, Chittaranjan S, Yokota, Mitsuhiro, Yuan, Jian-Min, Zeggini, Eleftheria, Zemel, Babette S, Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M, Zonderman, Alan B, Zwart, John-Anker, Chasman, Daniel I, Cho, Yoon Shin, Heid, Iris M, Mccarthy, Mark I, Ng, Maggie C Y, O'Donnell, Christopher J, Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Sun, Yan V, Tai, E Shyong, Boehnke, Michael, Deloukas, Pano, Justice, Anne E, Lindgren, Cecilia M, Loos, Ruth J F, Mohlke, Karen L, North, Kari E, Stefansson, Kari, Walters, Robin G, Winkler, Thomas W, Young, Kristin L, Loh, Po-Ru, Yang, Jian, Esko, Tõnu, Assimes, Themistocles L, Auton, Adam, Abecasis, Goncalo R, Willer, Cristen J, Locke, Adam E, Berndt, Sonja I, Lettre, Guillaume, Frayling, Timothy M, Okada, Yukinori, Wood, Andrew R, and Visscher, Peter M more...

Subjects
multi-ancestry, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Medizin, 45/43, Genome-wide association studies, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Linkage Disequilibrium, Gene Frequency, RARE, IMPUTATION, PRACTICAL Consortium, GWAS, genes, ARCHITECTURE, Genome, Human/genetics, Multidisciplinary, Body Height/genetics, HERITABILITY, SCORES, article, Chromosome Mapping, 631/208/721, Polymorphism, Single Nucleotide/genetics, 3142 Public health care science, environmental and occupational health, Nutritional Biology, Europe, Phenotype, Gene Frequency/genetics, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], VA Million Veteran Program, Molecular and Laser Physics, dimorphism, blood, lipid, Medical Genetics, Single Nucleotide/genetics, genetic variant, Understanding Society Scientific Group, height, genetic, Haplotypes/genetics, 631/208/205/2138, saturated map, 23andMe Research Team, Polymorphism, Single Nucleotide, single-nucleotide polymorphisms (SNPs), Europe/ethnology, Lifelines Cohort Study, RESOURCE, UK BIOBANK, REVEALS, Life Science, DiscovEHR (DiscovEHR and MyCode Community Health Initiative), Humans, Linkage Disequilibrium/genetics, genomic regions, Polymorphism, GENOME-WIDE ASSOCIATION, gene, genetic variants, human height, 631/208/480, VLAG, Medicinsk genetik, eMERGE (Electronic Medical Records and Genomics Network), Genome, Human, Spectroscopy of Cold Molecules, Quantitative traits, Genome, Human/genetics, Genome-Wide Association Study, Sample Size, Body Height, 3141 Health care science, Haplotypes, Genetic markers, 3111 Biomedicine
Abstract

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries. A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants. more...

Published
2022
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2. Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children's Oncology Group.

Author

Martin-Giacalone, Bailey A, Richard, Melissa A, Scheurer, Michael E, Khan, Javed, Sok, Pagna, Shetty, Priya B, Chanock, Stephen J, Li, Shengchao Alfred, Yeager, Meredith, Marquez-Do, Deborah A, Barkauskas, Donald A, Hall, David, McEvoy, Matthew T, Brown, Austin L, Sabo, Aniko, Scheet, Paul, Huff, Chad D, Skapek, Stephen X, Hawkins, Douglas S, and Venkatramani, Rajkumar more...

Subjects
GENETIC variation, RHABDOMYOSARCOMA, PROPORTIONAL hazards models, GENOME-wide association studies, SINGLE nucleotide polymorphisms
Abstract

Background Relative to other pediatric cancers, survival for rhabdomyosarcoma (RMS) has not improved in recent decades, suggesting the need to enhance risk stratification. Therefore, we conducted a genome-wide association study for event-free survival (EFS) and overall survival (OS) to identify genetic variants associated with outcomes in individuals with RMS. Methods The study included 920 individuals with newly diagnosed RMS who were enrolled in Children's Oncology Group protocols. To assess the association of each single nucleotide polymorphism (SNP) with EFS and OS, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) using multivariable Cox proportional hazards models, adjusted for clinical covariates. All statistical tests were two sided. We also performed stratified analyses by histological subtype (alveolar and embryonal RMS) and carried out sensitivity analyses of statistically significant SNPs by PAX3/7-FOXO1 fusion status and genetic ancestry group. Results We identified that rs17321084 was associated with worse EFS (HR = 2.01, 95% CI = 1.59 to 2.53, P  =   5.39   ×   10−9) and rs10094840 was associated with worse OS (HR = 1.84, 95% CI = 1.48 to 2.27, P  =   2.13   ×   10−8). Using publicly available data, we found that rs17321084 lies in a binding region for transcription factors GATA2 and GATA3, and rs10094840 is associated with SPAG1 and RNF19A expression. We also identified that CTNNA3 rs2135732 (HR = 3.75, 95% CI = 2.34 to 5.99, P  =   3.54   ×   10−8) and MED31 rs74504320 (HR = 3.21, 95% CI = 2.12 to 4.86, P  =   3.60   ×   10−8) were associated with worse OS among individuals with alveolar RMS. Conclusions We demonstrated that common germline variants are associated with EFS and OS among individuals with RMS. Additional replication and investigation of these SNP effects may further support their consideration in risk stratification protocols. [ABSTRACT FROM AUTHOR] more...

Published
2023
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3. cgaTOH: Extended Approach for Identifying Tracts of Homozygosity.

Author

Zhang, Li, Orloff, Mohammed S., Reber, Sean, Li, Shengchao, Zhao, Ye, and Eng, Charis

Subjects
HOMOZYGOSITY, SINGLE nucleotide polymorphisms, GENE mapping, PUBLIC health, COMPUTATIONAL biology, MEDICAL model
Abstract

Identification of disease variants via homozygosity mapping and investigation of the effects of genome-wide homozygosity regions on traits of biomedical importance have been widely applied recently. Nonetheless, the existing methods and algorithms to identify long tracts of homozygosity (TOH) are not able to provide efficient and rigorous regions for further downstream association investigation. We expanded current methods to identify TOHs by defining “surrogate-TOH”, a region covering a cluster of TOHs with specific characteristics. Our defined surrogate-TOH includes cTOH, viz a common TOH region where at least ten TOHs present; gTOH, whereby a group of highly overlapping TOHs share proximal boundaries; and aTOH, which are allelically-matched TOHs. Searching for gTOH and aTOH was based on a repeated binary spectral clustering algorithm, where a hierarchy of clusters is created and represented by a TOH cluster tree. Based on the proposed method of identifying different species of surrogate-TOH, our cgaTOH software was developed. The software provides an intuitive and interactive visualization tool for better investigation of the high-throughput output with special interactive navigation rings, which will find its applicability in both conventional association studies and more sophisticated downstream analyses. NCBI genome map viewer is incorporated into the system. Moreover, we discuss the choice of implementing appropriate empirical ranges of critical parameters by applying to disease models. This method identifies various patterned clusters of SNPs demonstrating extended homozygosity, thus one can observe different aspects of the multi-faceted characteristics of TOHs. [ABSTRACT FROM AUTHOR] more...

Published
2013
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4. Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia

Author

Laurie Burdette, Lindsay M. Morton, Neil E. Caporaso, Sonja I. Berndt, Paolo Vineis, Stephen J. Chanock, Stephen M. Ansell, Elisabete Weiderpass, James McKay, Charles C. Chung, Nisha Pradhan, James R. Cerhan, Peter Kraft, Alexandra Nieters, Lauren R. Teras, Lenka Foretova, Paul Brennan, Lesley F. Tinker, Susan L. Slager, Nilanjan Chatterjee, Jianqing Zhang, Caroline Besson, Mark P. Purdue, Zhaoming Wang, Shengchao Alfred Li, Bengt Glimelius, Paige M. Bracci, Qing Lan, Mervin M. Fansler, Jacqueline Clavel, Hans-Olov Adami, Ruth C. Travis, Karin E. Smedby, Christine F. Skibola, Silvia de Sanjosé, Edward Giovannucci, Akinyemi I. Ojesina, Huihuang Yan, Richard K. Severson, Jonathan N. Hofmann, Paolo Boffetta, Lynn R. Goldin, Yawei Zhang, Belynda Hicks, Bryan A. Bassig, Charles E. Lawrence, Andrew L. Feldman, Nathaniel Rothman, Jacques Riby, Yolanda Benavente, Nikolaus Becker, Geffen Kleinstern, Marc Maynadié, Meredith Yeager, Henrik Hjalgrim, Rebecca D. Jackson, Joseph Vijai, Tongzhang Zheng, Roel Vermeulen, Amy K. Hutchinson, Brenda M. Birmann, Bin Zhu, Kenneth Offit, Brian K. Link, Alex Smith, Anthony Staines, Christine Mayr, Federico Canzian, Lucia Conde, Rebecca Montalvan, Elizabeth E. Brown, Wendy Cozen, Anne J. Novak, Claire M. Vajdic, Ju-Hyun Park, W. Ryan Diver, Mary L. McMaster, Mads Melbye, Ann Maria, Kari E. North, Alain Monnereau, McMaster, Mary L., Berndt, Sonja I., Zhang, Jianqing, Slager, Susan L., Li, Shengchao Alfred, Vajdic, Claire M., Smedby, Karin E., Yan, Huihuang, Birmann, Brenda M., Brown, Elizabeth E., Smith, Alex, Kleinstern, Geffen, Fansler, Mervin M., Mayr, Christine, Zhu, Bin, Chung, Charles C., Park, Ju-Hyun, Burdette, Laurie, Hicks, Belynda D., Hutchinson, Amy, Teras, Lauren R., Adami, Hans-Olov, Bracci, Paige M., McKay, Jame, Monnereau, Alain, Link, Brian K., Vermeulen, Roel C. H., Ansell, Stephen M., Maria, Ann, Diver, W. Ryan, Melbye, Mad, Ojesina, Akinyemi I., Kraft, Peter, Boffetta, Paolo, Clavel, Jacqueline, Giovannucci, Edward, Besson, Caroline M., Canzian, Federico, Travis, Ruth C., Vineis, Paolo, Weiderpass, Elisabete, Montalvan, Rebecca, Wang, Zhaoming, Yeager, Meredith, Becker, Nikolau, Benavente, Yolanda, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, Nieters, Alexandra, de Sanjose, Silvia, Staines, Anthony, Conde, Lucia, Riby, Jacque, Glimelius, Bengt, Hjalgrim, Henrik, Pradhan, Nisha, Feldman, Andrew L., Novak, Anne J., Lawrence, Charle, Bassig, Bryan A., Lan, Qing, Zheng, Tongzhang, North, Kari E., Tinker, Lesley F., Cozen, Wendy, Severson, Richard K., Hofmann, Jonathan N., Zhang, Yawei, Jackson, Rebecca D., Morton, Lindsay M., Purdue, Mark P., Chatterjee, Nilanjan, Offit, Kenneth, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Vijai, Joseph, Goldin, Lynn R., Skibola, Christine F., Caporaso, Neil E., National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), International Agency for Cancer Research (IACR), Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Department of Internal Medicine [Iowa City], Carver College of Medicine [Iowa City], University of Iowa [Iowa City]-University of Iowa [Iowa City], Mayo Clinic [Rochester], Icahn School of Medicine at Mount Sinai [New York] (MSSM), The Tisch Cancer Institute, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Catalan Institute of Oncology (ICO-IDIBELL), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Masaryk Memorial Cancer Institute, Masaryk Memorial Cancer Institute (RECAMO), Registre des hématopathies malignes de Côte d'Or (RHEMCO), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université de Bourgogne (UB), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Carolina Center for Genome Sciences, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Keck School of Medicine [Los Angeles], University of Southern California (USC), Wayne State University [Detroit], Yale School of Public Health (YSPH), Ohio State University [Columbus] (OSU), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Memorial Sloane Kettering Cancer Center [New York], Emory University [Atlanta, GA], Department of Medical and Clinical Genetics, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL)-Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), One Health Chemisch, dIRAS RA-2, Sub Atmospheric physics and chemistry, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Sorbonne Paris Cité (USPC), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM) more...

Subjects
Genotyping Techniques, Inheritance Patterns, Genome-wide association study, enhanced green fluorescent protein, Lymphoplasmacytic Lymphoma, 0302 clinical medicine, Genes, Reporter, genetics, B-cell lymphoma, lcsh:Science, Malalties del sistema limfàtic, 1184 Genetics, developmental biology, physiology, Waldenstrom macroglobulinemia, Leucèmia, chromosome 14, reporter gene, 3. Good health, 030220 oncology & carcinogenesis, Science & Technology - Other Topics, Chromosomes, Human, Pair 6, NON-HODGKIN-LYMPHOMA, GERMINAL CENTER B, Human, Science, Green Fluorescent Protein, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Physics and Astronomy (all), LYMPHOPLASMACYTIC LYMPHOMA/WALDENSTROM MACROGLOBULINEMIA, Genetic predisposition, inheritance, Humans, Family, GENOME-WIDE ASSOCIATION, reproducibility, Inheritance Pattern, Cancer och onkologi, Science & Technology, Biochemistry, Genetics and Molecular Biology (all), VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, CHRONIC LYMPHOCYTIC-LEUKEMIA, nutritional and metabolic diseases, Molecular Sequence Annotation, medicine.disease, Chromosomes Human Pair 6, Lymphoma, 030104 developmental biology, Cancer and Oncology, Immunology, molecular genetics, lcsh:Q, HIGH-RESOLUTION, 0301 basic medicine, General Physics and Astronomy, Genome-wide association studies, HEK293 Cell, immune system diseases, single nucleotide polymorphism, Risk Factors, Chromosomes Human Pair 14, hemic and lymphatic diseases, Lymphatic diseases, EXPRESSION PATTERNS, FAMILIAL AGGREGATION, Multidisciplinary, Leukemia, Chemistry (all), MicroRNA, Waldenstroem macroglobulinemia, Multidisciplinary Sciences, HEK293 cell line, miRNAs, Waldenstrom Macroglobulinemia, Green Fluorescent Proteins, Reproducibility of Result, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Malignancy, Polymorphism, Single Nucleotide, Chromosomes, Cancer epidemiology, MD Multidisciplinary, medicine, chromosome 6, Genetic Predisposition to Disease, RAL GTPASES, Cell Proliferation, Chromosomes, Human, Pair 14, Base Sequence, Risk Factor, B-CELL LYMPHOMA, Reproducibility of Results, nucleotide sequence, General Chemistry, Heritability, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, MicroRNAs, HEK293 Cells, Genotyping Technique, genetic predisposition, metabolism
Abstract

Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40–31.03, P = 1.36 × 10−54) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45–6.96, P = 8.75 × 10−19). Both risk alleles are observed at a low frequency among controls (~2–3%) and occur in excess in affected cases within families. In silico data suggest that rs116446171 may have functional importance, and in functional studies, we demonstrate increased reporter transcription and proliferation in cells transduced with the 6p25.3 risk allele. Although further studies are needed to fully elucidate underlying biological mechanisms, together these loci explain 4% of the familial risk and provide insights into genetic susceptibility to this malignancy., Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a non-Hodgkin-type B cell lymphoma. Here, the authors identify two risk loci for WM/LPL in a two-stage GWAS involving a family-oversampling approach and provide evidence for a functional role of the non-coding SNP rs116446171. more...

Published
2018
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