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Start Over Descriptor "MESH: Genital Neoplasms, Female" Topic genital neoplasms, female
6 results on '"MESH: Genital Neoplasms, Female"'

1. Prospective Assessment of First-Year Quality of Life After Pelvic Exenteration for Gynecologic Malignancy: A French Multicentric Study

Author

G. Ferron, P. Morice, Frédéric Marchal, I. Jaffré, Michel Rivoire, Eric Lambaudie, G. Houvenaeghel, Denis Querleu, Eberhard Stoeckle, F. Foucher, Pierre Meeus, Sebastien Gouy, Thomas Filleron, J-M Classe, Pierre-Emmanuel Colombo, N. Chopin, Vincent Lavoué, Fabrice Narducci, Jean Levêque, Eva Jouve, Philippe Rouanet, Frédéric Guyon, Alejandra Martinez, J. L. Verheaghe, Eric Leblanc, A. Mourregot, Institut Claudius Regaud, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CRLCC Val d'Aurelle - Paul Lamarque, Centre Léon Bérard [Lyon], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, CHU Pontchaillou [Rennes], Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Département de chirurgie gynécologique [Gustave Roussy], Institut Gustave Roussy (IGR), Institut Bergonié [Bordeaux], Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Lille Nord de France (COMUE)-UNICANCER, CRLCC Institut Claudius Regaud, Institut de cancérologie de l'Ouest - Nantes (ICO Nantes), CRLCC Paul Papin-CRLCC René Gauducheau, CRLCC Oscar Lambret, Institut Bergonié - CRLCC Bordeaux, and Institut de Cancérologie de Lorraine - Alexis Vautrin (ICL)

Subjects
medicine.medical_treatment, 0302 clinical medicine, MESH: Pelvic Exenteration, MESH: Genital Neoplasms, Female, Quality of life, Surgical oncology, MESH: Postoperative Period, Surveys and Questionnaires, Medicine, Postoperative Period, Prospective Studies, Prospective cohort study, MESH: Aged, 030219 obstetrics & reproductive medicine, MESH: Middle Aged, MESH: Follow-Up Studies, Middle Aged, Prognosis, humanities, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Female, medicine.symptom, Psychosocial, Adult, medicine.medical_specialty, Genital Neoplasms, Female, [SDV.CAN]Life Sciences [q-bio]/Cancer, Anorexia, MESH: Prognosis, 03 medical and health sciences, Body Image, Humans, MESH: Surveys and Questionnaires, MESH: Body Image, Aged, MESH: Humans, Pelvic exenteration, business.industry, General surgery, MESH: Quality of Life, MESH: Adult, MESH: Prospective Studies, Pelvic Exenteration, Surgery, Gynecologic malignancy, Quality of Life, Sexual function, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract

International audience; BACKGROUND:Pelvic exenteration remains one of the most mutilating procedures, with important postoperative morbidity, an altered body image, and long-term physical and psychosocial concerns. This study aimed to assess quality of life (QOL) during the first year after pelvic exenteration for gynecologic malignancy performed with curative intent.METHODS:A French multicentric prospective study was performed by including patients who underwent pelvic exenteration. Quality of life by measurement of functional and symptom scales was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 (version 3.0) and the EORTC QLQ-OV28 questionnaires before surgery, at baseline, and 1, 3, 6, and 12 months after the procedure.RESULTS:The study enrolled 97 patients. Quality of life including physical, personal, fatigue, and anorexia reported in the QLQ-C30 was significantly reduced 1 month postoperatively and improved at least to baseline level 1 year after the procedure. Body image also was significantly reduced 1 month postoperatively. Global health, emotional, dyspnea, and anorexia items were significantly improved 1 year after surgery compared with baseline values. Unlike younger patients, elderly patients did not regain physical and social activities after pelvic exenteration.CONCLUSIONS:Therapeutic decision on performing a pelvic exenteration can have a severe and permanent impact on all aspects of patients' QOL. Deterioration of QOL was most significant during the first 3 months after surgery. Elderly patients were the only group of patients with permanent decreased physical and social function. Preoperative evaluation and postoperative follow-up evaluation should include health-related QOL instruments, counseling by a multidisciplinary team to cover all aspects concerning stoma care, sexual function, and long-term concerns after surgery.

Published
2018
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2. Cell-free nucleic acids as non-invasive biomarkers of gynecological cancers, ovarian, endometrial and obstetric disorders and fetal aneuploidy

Author

Said Assou, Sabine Traver, E. Scalici, S. Belloc, Delphine Haouzi, T. Al-Edani, Samir Hamamah, Cellules souches normales et cancéreuses, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire Eylau-Unilabs [Neuilly-sur-Seine ] (Clinique Pierre-Cherest), Clinique Pierre Cherest [Neuilly-Sur-Seine], Hôpital Arnaud de Villeneuve [CHRU Montpellier], Développement embryonnaire précoce humain et pluripotence EmbryoPluripotency (UMR 1203), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-CHU Montpellier, and Herrada, Anthony

Subjects
Pathology, Ovarian Disorder, Bioinformatics, MESH: Genital Neoplasms, Female, MESH: Pregnancy, 0302 clinical medicine, MESH: Uterine Diseases, Pregnancy, Nucleic Acids, MESH: Embryonic Development, Ovarian Diseases, Uterine Diseases, 0303 health sciences, 030219 obstetrics & reproductive medicine, Female infertility, Obstetrics and Gynecology, Prognosis, MESH: Ovarian Diseases, 3. Good health, Cell-Free Nucleic Acids, Cell-free fetal DNA, Biomarker (medicine), Female, MESH: Biomarkers, Tumor, infertility, Embryo quality, Infertility, medicine.medical_specialty, non-invasive biomarkers, Genital Neoplasms, Female, Embryonic Development, Biology, MESH: Prognosis, cell-free DNA, 03 medical and health sciences, Fetus, Biomarkers, Tumor, MESH: Aneuploidy, medicine, Humans, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, 030304 developmental biology, MESH: Humans, MESH: Fetus, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Aneuploidy, MESH: Nucleic Acids, medicine.disease, MicroRNAs, Reproductive Medicine, MESH: Biomarkers, MESH: Genital Diseases, Female, Genital Diseases, Female, MESH: MicroRNAs, MESH: Female, Biomarkers
Abstract

International audience; Background: Proper folliculogenesis is fundamental to obtain a competent oocyte that, once fertilized, can support the acquisition of embryo developmental competence and pregnancy. MicroRNAs (miRNAs) are crucial regulators of folliculogenesis, which are expressed in the cumulus-oocyte complex and in granulosa cells and some can also be found in the bloodstream. These circulating miRNAs are intensively studied and used as diagnostic/prognostic markers of many diseases, including gynecological and pregnancy disorders. In addition, serum contains small amounts of cell-free DNA (cfDNA), presumably resulting from the release of genetic material from apoptotic/necrotic cells. The quantification of nucleic acids in serum samples could be used as a diagnostic tool for female infertility.Methods: An overview of the published literature on miRNAs, and particularly on the use of circulating miRNAs and cfDNA as non-invasive biomarkers of gynecological diseases, was performed (up to January 2014).Results: In the past decade, cell-free nucleic acids have been studied for potential use as biomarkers in many diseases, particularly in gynecological cancers, ovarian and endometrial disorders, as well as in pregnancy-related pathologies and fetal aneuploidy. The data strongly suggest that the concentration of cell-free nucleic acids in serum from IVF patients or in embryo culture medium could be related to the ovarian hormone status and embryo quality, respectively, and be used as a non-invasive biomarker of IVF outcome.Conclusions: The profiling of circulating nucleic acids, such as miRNAs and cfDNA, opens new perspectives for the diagnosis/prognosis of ovarian disorders and for the prediction of IVF outcomes, namely (embryo quality and pregnancy).

Published
2014
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3. [Brachytherapy training: a survey of French radiation oncology residents]

Author

Fumagalli, I, Faivre, J-C, Thureau, S, Bibault, J-E, Diaz, O, Leroy, T, Pichon, B, Riou, O, Fournier, C, Hannoun-Lévi, J-M, Peiffert, D, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, IFP Energies nouvelles (IFPEN), Radiothérapie Oncologique, Université de Montpellier (UM), Institut National de Prévention et d'Education pour la Santé (INPES), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), and Centre Alexis Vautrin (CAV)

Subjects
Male, Genital Neoplasms, Female, Teaching Materials, [SDV]Life Sciences [q-bio], Brachytherapy, MESH: Cross-Sectional Studies, MESH: Genital Neoplasms, Female, MESH: Internship and Residency, Surveys and Questionnaires, Humans, MESH: Data Collection, MESH: Radiotherapy Dosage, MESH: Radiotherapy Planning, Computer-Assisted, MESH: Humans, MESH: Curriculum, Data Collection, Radiotherapy Planning, Computer-Assisted, MESH: Questionnaires, Internship and Residency, Prostatic Neoplasms, MESH: Teaching Materials, Radiotherapy Dosage, MESH: Radiation Oncology, MESH: Male, MESH: France, Cross-Sectional Studies, MESH: Prostatic Neoplasms, Radiation Oncology, Female, Curriculum, France, MESH: Brachytherapy, MESH: Female
Abstract

International audience; The goal of this study was to evaluate the interest of the members of the French society of young radiation oncologists (SFjRO) for brachytherapy as well as their theoretical and practical level in this radiation technique. An anonymous survey was conducted regarding practical and theoretical teaching of brachytherapy before the French national courses on brachytherapy. Among the 106 residents attending this teaching course, 99 (93%) answered the survey. Most of them were interested in brachytherapy but 82% considered they had not received sufficient teaching. Relevant indications of brachytherapy were known by 76% of the residents for gynaecological malignancies and 70% for prostate. Seventy-one percent of the residents have seen at least one gynecological brachytherapy but only 12% knew how to deal with this technique. Fifty-six percent have seen vaginal high dose rate brachytherapy and 21% had acquired the technique. For prostate brachytherapy, 65% had seen and done an implant and only 4% had acquired the technique. Fifty percent have performed at least one brachytherapy treatment during their residency. Residents expressed a strong wish for more courses about dosimetry (82%), technique (75%) and treatment planning (90%). Our study shows the interest of French residents for brachytherapy but suggests that practical teaching courses and an evaluation of the existing theoretical courses are warranted.

Published
2014

4. [PAIR-gynaecology: multi/interdisciplinary for gynecologic cancer research. Problems needed to be resolved]

Author

Ray-Coquard, Isabelle, Chauvin, Franck, Leblanc, Eric, Caux, Christophe, Hoarau, Hélène, Bonnetain, Franck, Christophe, Véronique, Sastre-Garau, Xavier, Lazennec, Gwendal, Poulain, Laurent, Haie-Meder, Christine, Pujade-Lauraine, Eric, Salzet, Michel, Deutsch, Eric, Devouassoux, Mojgan, Penault Llorca, Frédérique, Lecuru, Fabrice, Taieb, Sophie, Arveux, Patrick, Theillet, Charles, Joly, Florence, Département d'Oncologie Médicale, Centre Léon Bérard [Lyon], Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Cancérologie Lucien Neuwirth, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Department of Surgery, Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER-Université de Lille-UNICANCER, Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Département de Biologie des Tumeurs, Institut Curie [Paris], Cellules souches mésenchymateuses, environnement articulaire et immunothérapies de la polyarthrite rhumatoide, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Régional d'Etudes sur le CANcer (GRECAN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-IFR146, Service d'Oncologie Médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neuroimmunologie des annélides (NA), Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), Hopitaux de Paris, Université Paris Descartes - Paris 5 (UPD5), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Etienne, Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER, Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), IFR146-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CRLCC Oscar Lambret, Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), Institut Curie, IFR146-Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Hôtel-Dieu [Paris]-AP-HP, Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Centre Léon Bérard [Lyon]-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Santé-Individu-Société 'SIS', Centre de Recherche en Cancérologie de Lyon ( CRCL ), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), INSTITUT CURIE, Université Montpellier 1 ( UM1 ) -IFR3-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Groupe Régional d'Etudes sur le CANcer ( GRECAN ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Centre Régional de Lutte contre le Cancer François Baclesse ( CRLC François Baclesse ) -IFR146, Université Paris Descartes - Paris 5 ( UPD5 ) -Hôpital Hôtel-Dieu [Paris]-AP-HP, Neuroimmunologie des annélides ( NA ), Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique ( CNRS ), Université Paris Descartes - Paris 5 ( UPD5 ), Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Institut de recherche en cancérologie de Montpellier ( IRCM - U896 Inserm - UM1 ), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier ( UM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Montpellier 1 ( UM1 ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Institut de recherche en cancérologie de Montpellier ( IRCM ), and Université Montpellier 1 ( UM1 ) -CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM )

Subjects
Biomedical Research, Uterine Cervical Neoplasms, MESH : Early Detection of Cancer, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, MESH: Genital Neoplasms, Female, Risk Factors, MESH : Fertility, MESH: Risk Factors, MESH : Tumor Markers, Biological, MESH : Female, Immunologic Surveillance, Early Detection of Cancer, Ovarian Neoplasms, DNA, Neoplasm, MESH : Risk Factors, MESH: Uterine Cervical Neoplasms, MESH: Ovarian Neoplasms, MESH: Sexuality, MESH : Sexuality, Female, France, MESH : DNA, Neoplasm, MESH: Endometrial Neoplasms, Sexuality, MESH : Biomedical Research, Genital Neoplasms, Female, MESH : Uterine Cervical Neoplasms, MESH : Genital Neoplasms, Female, MESH: DNA, Neoplasm, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biomarkers, Tumor, Humans, MESH: Early Detection of Cancer, MESH : France, MESH: Immunologic Surveillance, MESH: Humans, MESH : Ovarian Neoplasms, MESH: Biomedical Research, MESH : Humans, MESH: Quality of Life, MESH: Fertility, MESH : Quality of Life, Endometrial Neoplasms, MESH: France, MicroRNAs, MESH : MicroRNAs, Fertility, MESH : Endometrial Neoplasms, MESH: Tumor Markers, Biological, Quality of Life, MESH : Immunologic Surveillance, MESH: MicroRNAs, MESH: Female
Abstract

International audience; Each year, 13,000 newly gynecologic cancers are diagnosed in France. Gynecologic cancers were specifically heterogeneous (localisations, histologic subgroups, age class, etc). This work was delineated for a national call dedicated to gynecologic cancers. This review reports the major needs in terms of scientific research dedicated to gynecologic cancers in the biologic, epidemiology, human and sociologic fields. For example, medico-economic strategies adapted to ethnosociologic context, specifically for cervix cancer, took important part of the epidemiologic research. Impact of gynecologic cancer in terms of symptoms and late effects, quality of life after treatments and fertility needs to be specifically explored. For fundamental research, molecular characterisation, biologic markers, impact of immunology and genetics represent the major part of the field need to be explored. Finally, therapeutic and diagnosis innovations, optimization of treatments strategies and development of predictive models in order to perform individual prediction taking into account several risk factors (clinical and molecular) to offer help in management of gynecologic cancers are required.

Published
2012
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5. Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis

Author

Marc Debouverie, Patrick Vermersch, Jérôme De Seze, Christine Lebrun, Arlette Danzon, Sandrine Wiertlevski, Frédéric Berthier, Lucien Rumbach, Pierre Clavelou, Olivier Gout, Gilles Defer, Laboratoire d'Imagerie et de Neurosciences Cognitives ( LINC ), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Neuroimagerie in Vivo ( LNV ), CHU Strasbourg-Centre National de la Recherche Scientifique ( CNRS ), Service de Neurologie, Fondation A. Rothschild, Département d'Informatique Médicale, CHU Nice-Hôpital Cimiez [Nice] ( CHU ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuroimagerie in Vivo (LNV), CHU Strasbourg-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital Cimiez [Nice] (CHU), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Université de Franche-Comté (UFC)

Subjects
Male, Skin Neoplasms, MESH : Multiple Sclerosis, MESH : Urologic Neoplasms, MESH : Breast Neoplasms, Digestive System Neoplasms, MESH : Central Nervous System Neoplasms, MESH: Central Nervous System Neoplasms, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, Central Nervous System Neoplasms, 0302 clinical medicine, MESH: Genital Neoplasms, Female, MESH : Azathioprine, Azathioprine, MESH: Incidence, MESH : Immunosuppressive Agents, education.field_of_study, MESH: Middle Aged, MESH: Peptides, MESH : Peptides, Incidence, MESH : Incidence, 3. Good health, Neurology, 030220 oncology & carcinogenesis, MESH: Mitoxantrone, MESH: Immunosuppressive Agents, medicine.medical_specialty, Multiple Sclerosis, MESH : Genital Neoplasms, Female, 03 medical and health sciences, MESH : Interferon-beta, Humans, MESH : Middle Aged, Risk factor, education, Cyclophosphamide, MESH: Azathioprine, MESH: Humans, MESH: Interferon-beta, MESH : Leukemia, MESH : Humans, MESH: Cyclophosphamide, MESH: Adult, Glatiramer Acetate, Interferon-beta, medicine.disease, MESH : Neoplasms, Neurology (clinical), MESH : Digestive System Neoplasms, Mitoxantrone, Peptides, MESH: Lymphoma, MESH: Female, 030217 neurology & neurosurgery, Lymphoma, MESH: Registries, Risk Factors, MESH: Risk Factors, Neoplasms, MESH: Neoplasms, MESH : Female, Registries, MESH : Cyclophosphamide, Acute leukemia, Leukemia, MESH: Urologic Neoplasms, Incidence (epidemiology), Middle Aged, MESH : Adult, MESH : Risk Factors, Female, Immunosuppressive Agents, medicine.drug, Adult, Urologic Neoplasms, Genital Neoplasms, Female, MESH : Male, Population, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH : Lymphoma, Internal medicine, MESH: Leukemia, medicine, business.industry, MESH: Digestive System Neoplasms, Multiple sclerosis, MESH: Skin Neoplasms, MESH : Skin Neoplasms, Cancer, MESH: Multiple Sclerosis, MESH: Male, Surgery, MESH : Mitoxantrone, business, MESH: Breast Neoplasms, MESH : Registries
Abstract

Background Prior to the era of immunomodulating or immunosuppressive (IS) treatments Multiple Sclerosis (MS) was linked to reduced rates of cancer. Method A descriptive study of MS patients with a documented oncological event was performed. From 1 January 1995 to 30 June 2006, we collected and studied the profile of 7418 MS patients gathered from nine French MS centers. We evaluated the incidence of cancer in a Cancer Risk In MS Cohort. Results Thirty one patients (1.75%) with confirmed MS had a history of cancer: mean age at MS diagnosis of 37.9 years and a mean age at cancer diagnosis of 46.4 years. The most frequent cancers were breast (34.5%), gynecological (12.5%), skin (10.2%), acute leukemia and lymphoma (5.9%), digestive (8.8%), kidney and bladder (5.1%), lung (3.4%) and central nervous system (3%). Calculated standardized incidence rates were 0.29 (0.17—0.45) for men and 0.53 (0.42—0.66) for women. The incidence of cancer in this MS population was lower than that expected for the general population. Matched to age, gender and histology, cancers in MS were associated with a young age and exposure to IS treatments. When considering all patients, treated patients had a 3-fold higher risk of developing cancer, if they had a history of IS ( P = 0.0035). For treated patients, the cancer sites were more likely the breast, the urinary tract, the digestive system and the skin. Conclusion Our data suggest that MS patients do not have an increased risk of cancer. Rather for several types of cancer a significantly reduced risk was observed, except for breast cancer in women treated with IS. The relative increased risk of breast cancer in MS women under IS treatment warrants further attention. Multiple Sclerosis 2008; 14: 399—405. http://msj.sagepub.com

Published
2008
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6. Squamous cell carcinomas in Afro-Caribbean women

Author

Lucie Bonnecarrère, Benoit Tressières, Nadège Cordel, ADENIS, ANTOINE, Dermatologie-Médecine Interne, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), and Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]

Subjects
medicine.medical_specialty, Skin Neoplasms, Genital Neoplasms, Female, MEDLINE, Black People, Dermatology, Afro-Caribbean, MESH: Anus Neoplasms, MESH: Aged, 80 and over, MESH: Genital Neoplasms, Female, Carcinoma, medicine, Humans, MESH: Guadeloupe, Guadeloupe, Aged, Aged, 80 and over, MESH: Aged, MESH: Humans, MESH: Middle Aged, business.industry, MESH: Skin Neoplasms, MESH: Carcinoma, Squamous Cell, Middle Aged, Anus Neoplasms, medicine.disease, Anus neoplasms, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Carcinoma, Squamous Cell, Genital neoplasm, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: African Continental Ancestry Group, business, MESH: Female
Abstract

International audience; Squamous cell carcinoma (SCC) of the lower limbs is a common occurrence in patients of African descent as reported by several large series. 1, 2 and 3 In light of their two initial cases occurring in African American women, Woolery-Lloyd et al4 recently focused on this localization for the differential diagnosis of hyperpigmented plaques on the lower limbs of elderly African American women

Published
2012
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