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Purpose Juvenile-onset open-angle glaucoma (JOAG) is an uncommon type of primary open-angle glaucoma that affects individuals during childhood and early adulthood. Pathogenic variants in the myocilin gene account for varying frequencies of primary open-angle glaucoma and JOAG cases in different populations. This study has screened and identified novel and previously identified myocilin variants in a north Indian cohort of JOAG patients. Methods Eighty unrelated JOAG cases and one hundred controls have been screened for MYOC variants by PCR and DNA sequencing of exons. Results DNA sequencing revealed seventeen different variants. Out of these variants, five (p.G122A, p.R136I, p.S173T, p.K216I, and p.R200KTer*15) were novel and registered in NCBI. Pathogenic MYOC variants identified in 7.5% of JOAG cases. Conclusion Pathogenic myocilin variants account for 7.5% of cases of JOAG in our patient’s cohort. This study augments the mutation spectrum of the MYOC gene, provides population-specific information, and aids in better understanding the underlying lesions of the disease.

We present 2 cases of calcification of posterior chamber intraocular lenses (IOLs) that presented to the outpatient department of our institute with diminution of vision a few months after successful cataract surgery. Intraocular lens exchange with a hydrophobic IOL was performed in both cases, resulting in a restoration of vision.

Background: The objective of this study is to determine the prevalence and the causes of low vision among school going children in and around Rohtak district of Haryana, India. Such information is important in planning for prevention of low vision and blindness strategies.Methods: 2028 school children studying in class 1-5 were screened in the school premises. Visual acuity was assessed with Snellen’s chart and colour vision was tested with ishihara colour vision book. Those with vision

We report two cases of electrical cataract developing after a high-voltage electric shock. Both patients had undergone cataract extraction and posterior chamber intraocular lens implantation, both of them achieved visual acuity of 6/6. Most of the times outcomes after the cataract surgeries are excellent provided that other ocular structures are undamaged. Anterior subcapsular opacity may hamper the lens nutrition and lead to cataract formation.