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Precocious diagnosis increases the survival time and patient quality of life. It is a binary classification, exhaustively studied in the literature. This paper innovates proposing the application of genetic programming to obtain a discriminate function. This function contains the disease dynamics used to classify the patients with as little false negative diagnosis as possible. If its value is greater than zero then it means that the patient is ill, otherwise healthy. A graphical representation is proposed to show the influence of each dataset attribute in the discriminate function. The experiment deals with Breast Cancer and Thrombosis & Collagen diseases diagnosis. The main conclusion is that the discriminate function is able to classify the patient using numerical clinical data, and the graphical representation displays patterns that allow understanding of the model.

Medical databases usually contain missing values due the policy of reducing stress and harm to the patient. In practice missing values has been a problem mainly due to the necessity to evaluate mathematical equations obtained by genetic programming. The solution to this problem is to use fill in methods to estimate the missing values. This paper analyses three fill in methods: (1) attribute means, (2) conditional means, and (3) random number generation. The methods are evaluated using sensitivity, specificity, and entropy to explain the exchange in knowledge of the results. The results are illustrated based on the breast cancer database. Conditional means produced the best fill in experimental results.