1. Impact of the Ile105Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population.
- Author
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Chielle EO, Trott A, da Silva Rosa B, Casarin JN, Fortuna PC, da Cruz IBM, Moretto MB, and Moresco RN
- Subjects
- Adult, Amino Acid Substitution, Female, Humans, Male, Obesity enzymology, Young Adult, Alleles, Genetic Predisposition to Disease, Glutathione S-Transferase pi genetics, Mutation, Missense, Obesity genetics, Polymorphism, Restriction Fragment Length
- Abstract
The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile
105 Val gene polymorphism of the study participants. Also, biochemical analysis and hormone assays were carried out. A positive association between GSTP1 polymorphism and obesity was observed on subjects carrying at least one G allele (AG and GG). GG genotype was found only in the obese group. The G allele carriers presented 2.4 times higher chance of obesity when compared to those with the AA genotype. These results were independent of sex and age. We suggest that despite a study in population regional (south of Brazil), the GSTP1 gene polymorphism may play a significant role in the increase of susceptibility of obesity and contribute to identify the cardiovascular risk in young adults., Competing Interests: Conflict of interest:: There are no conflicts of interest., (© Georg Thieme Verlag KG Stuttgart · New York.)- Published
- 2017
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