Author: "Holm, Hilma" / Topic: genetic loci - Searchworks@Jio Institute Digital Library Search Results

19 results on '"Holm, Hilma"'

1. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.

Author: Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G, Ramond A, Sørensen E, Halldorsson GH, Paul DS, Burgdorf KS, Eggertsson HP, Howson JMM, Thørner LW, Kristmundsdottir S, Astle WJ, Erikstrup C, Sigurdsson JK, Vuckovic D, Dinh KM, Tragante V, Surendran P, Pedersen OB, Vidarsson B, Jiang T, Paarup HM, Onundarson PT, Akbari P, Nielsen KR, Lund SH, Juliusson K, Magnusson MI, Frigge ML, Oddsson A, Olafsson I, Kaptoge S, Hjalgrim H, Runarsson G, Wood AM, Jonsdottir I, Hansen TF, Sigurdardottir O, Stefansson H, Rye D, Peters JE, Westergaard D, Holm H, Soranzo N, Banasik K, Thorleifsson G, Ouwehand WH, Thorsteinsdottir U, Roberts DJ, Sulem P, Butterworth AS, Gudbjartsson DF, Danesh J, Brunak S, Di Angelantonio E, Ullum H, and Stefansson K
Subjects: Humans, Biomarkers blood, Denmark, Ferritins blood, Genome-Wide Association Study, Genotype, Homeostasis, Iceland, Phenotype, Risk Assessment, Risk Factors, Transferrin metabolism, United Kingdom, Anemia, Iron-Deficiency blood, Anemia, Iron-Deficiency diagnosis, Anemia, Iron-Deficiency genetics, Genetic Loci, Genetic Variation, Iron blood, Iron Overload blood, Iron Overload diagnosis, Iron Overload genetics
Abstract: Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.
Published: 2021
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2. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Author: Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A, Morris AP, Del Greco M F, Foco L, Gögele M, Hicks AA, Cook JP, Lind L, Lindgren CM, Sundström J, Nelson CP, Riaz MB, Samani NJ, Sinagra G, Ulivi S, Kähönen M, Mishra PP, Mononen N, Nikus K, Caulfield MJ, Dominiczak A, Padmanabhan S, Montasser ME, O'Connell JR, Ryan K, Shuldiner AR, Aeschbacher S, Conen D, Risch L, Thériault S, Hutri-Kähönen N, Lehtimäki T, Lyytikäinen LP, Raitakari OT, Barnes CLK, Campbell H, Joshi PK, Wilson JF, Isaacs A, Kors JA, van Duijn CM, Huang PL, Gudnason V, Harris TB, Launer LJ, Smith AV, Bottinger EP, Loos RJF, Nadkarni GN, Preuss MH, Correa A, Mei H, Wilson J, Meitinger T, Müller-Nurasyid M, Peters A, Waldenberger M, Mangino M, Spector TD, Rienstra M, van de Vegte YJ, van der Harst P, Verweij N, Kääb S, Schramm K, Sinner MF, Strauch K, Cutler MJ, Fatkin D, London B, Olesen M, Roden DM, Benjamin Shoemaker M, Gustav Smith J, Biggs ML, Bis JC, Brody JA, Psaty BM, Rice K, Sotoodehnia N, De Grandi A, Fuchsberger C, Pattaro C, Pramstaller PP, Ford I, Wouter Jukema J, Macfarlane PW, Trompet S, Dörr M, Felix SB, Völker U, Weiss S, Havulinna AS, Jula A, Sääksjärvi K, Salomaa V, Guo X, Heckbert SR, Lin HJ, Rotter JI, Taylor KD, Yao J, de Mutsert R, Maan AC, Mook-Kanamori DO, Noordam R, Cucca F, Ding J, Lakatta EG, Qian Y, Tarasov KV, Levy D, Lin H, Newton-Cheh CH, Lunetta KL, Murray AD, Porteous DJ, Smith BH, Stricker BH, Uitterlinden A, van den Berg ME, Haessler J, Jackson RD, Kooperberg C, Peters U, Reiner AP, Whitsel EA, Alonso A, Arking DE, Boerwinkle E, Ehret GB, Soliman EZ, Avery CL, Gogarten SM, Kerr KF, Laurie CC, Seyerle AA, Stilp A, Assa S, Abdullah Said M, Yldau van der Ende M, Lambiase PD, Orini M, Ramirez J, Van Duijvenboden S, Arnar DO, Gudbjartsson DF, Holm H, Sulem P, Thorleifsson G, Thorolfsdottir RB, Thorsteinsdottir U, Benjamin EJ, Tinker A, Stefansson K, Ellinor PT, Jamshidi Y, Lubitz SA, and Munroe PB
Subjects: Arrhythmias, Cardiac physiopathology, Cardiovascular Diseases genetics, Cardiovascular Diseases physiopathology, Endophenotypes, Female, Gene Expression, Genetic Variation, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance, Quantitative Trait Loci genetics, Arrhythmias, Cardiac genetics, Electrocardiography, Genetic Loci genetics, Genetic Predisposition to Disease genetics
Abstract: The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.
Published: 2020
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3. Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.

Author: Olafsdottir T, Thorleifsson G, Sulem P, Stefansson OA, Medek H, Olafsson K, Ingthorsson O, Gudmundsson V, Jonsdottir I, Halldorsson GH, Kristjansson RP, Frigge ML, Stefansdottir L, Sigurdsson JK, Oddsson A, Sigurdsson A, Eggertsson HP, Melsted P, Halldorsson BV, Lund SH, Styrkarsdottir U, Steinthorsdottir V, Gudmundsson J, Holm H, Tragante V, Asselbergs FW, Thorsteinsdottir U, Gudbjartsson DF, Jonsdottir K, Rafnar T, and Stefansson K
Subjects: Body Mass Index, Case-Control Studies, Comorbidity, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Iceland epidemiology, Phenotype, Risk Assessment, Risk Factors, United Kingdom epidemiology, Uterine Prolapse diagnosis, Uterine Prolapse epidemiology, Extracellular Matrix Proteins genetics, Genetic Loci, Polymorphism, Single Nucleotide, Uterine Prolapse genetics, Wnt4 Protein genetics
Abstract: Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis code and 340,734 female controls, and found eight sequence variants at seven loci associating with POP (P < 5 × 10 -8 ); seven common (minor allele frequency >5%) and one with minor allele frequency of 4.87%. Some of the variants associating with POP also associated with traits of similar pathophysiology. Of these, rs3820282, which may alter the estrogen-based regulation of WNT4, also associates with leiomyoma of uterus, gestational duration and endometriosis. Rs3791675 at EFEMP1, a gene involved in connective tissue homeostasis, also associates with hernias and carpal tunnel syndrome. Our results highlight the role of connective tissue metabolism and estrogen exposure in the etiology of POP.
Published: 2020
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4. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Author: Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kääb S, Kanters JK, Kooperberg C, Lehtimäki T, Lin HJ, Lubitz SA, Mook-Kanamori DO, Conti FJ, Newton-Cheh CH, Rosand J, Rudan I, Samani NJ, Sinagra G, Smith BH, Holm H, Stricker BH, Ulivi S, Sotoodehnia N, Apte SS, van der Harst P, Stefansson K, Munroe PB, Arking DE, Lo CW, and Jamshidi Y
Subjects: Animals, Black People, Electrocardiography, Female, Gene Expression, Gene Expression Profiling, Genome-Wide Association Study, Heart Conduction System physiopathology, Humans, Male, Mice, Middle Aged, Myocardium pathology, Open Reading Frames, Polymorphism, Single Nucleotide, White People, Exome Sequencing, ADAMTS Proteins genetics, Connexin 43 genetics, Exome, Genetic Loci, Heart Conduction System metabolism, Myocardium metabolism
Abstract: Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear., Results: Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874 individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, including ADAMTS6, significantly associated with QRS duration in gene-based analyses. ADAMTS6 encodes a secreted metalloprotease of currently unknown function. In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction., Conclusions: Our approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes.
Published: 2018
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5. Seventy-five genetic loci influencing the human red blood cell.

Author: van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, Al-Hussani A, Asselbergs FW, Ciullo M, Danjou F, Dina C, Esko T, Evans DM, Franke L, Gögele M, Hartiala J, Hersch M, Holm H, Hottenga JJ, Kanoni S, Kleber ME, Lagou V, Langenberg C, Lopez LM, Lyytikäinen LP, Melander O, Murgia F, Nolte IM, O'Reilly PF, Padmanabhan S, Parsa A, Pirastu N, Porcu E, Portas L, Prokopenko I, Ried JS, Shin SY, Tang CS, Teumer A, Traglia M, Ulivi S, Westra HJ, Yang J, Zhao JH, Anni F, Abdellaoui A, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B, Boehm BO, Cookson WO, Das D, de Bakker PI, de Boer RA, de Geus EJ, de Moor MH, Dimitriou M, Domingues FS, Döring A, Engström G, Eyjolfsson GI, Ferrucci L, Fischer K, Galanello R, Garner SF, Genser B, Gibson QD, Girotto G, Gudbjartsson DF, Harris SE, Hartikainen AL, Hastie CE, Hedblad B, Illig T, Jolley J, Kähönen M, Kema IP, Kemp JP, Liang L, Lloyd-Jones H, Loos RJ, Meacham S, Medland SE, Meisinger C, Memari Y, Mihailov E, Miller K, Moffatt MF, Nauck M, Novatchkova M, Nutile T, Olafsson I, Onundarson PT, Parracciani D, Penninx BW, Perseu L, Piga A, Pistis G, Pouta A, Puc U, Raitakari O, Ring SM, Robino A, Ruggiero D, Ruokonen A, Saint-Pierre A, Sala C, Salumets A, Sambrook J, Schepers H, Schmidt CO, Silljé HH, Sladek R, Smit JH, Starr JM, Stephens J, Sulem P, Tanaka T, Thorsteinsdottir U, Tragante V, van Gilst WH, van Pelt LJ, van Veldhuisen DJ, Völker U, Whitfield JB, Willemsen G, Winkelmann BR, Wirnsberger G, Algra A, Cucca F, d'Adamo AP, Danesh J, Deary IJ, Dominiczak AF, Elliott P, Fortina P, Froguel P, Gasparini P, Greinacher A, Hazen SL, Jarvelin MR, Khaw KT, Lehtimäki T, Maerz W, Martin NG, Metspalu A, Mitchell BD, Montgomery GW, Moore C, Navis G, Pirastu M, Pramstaller PP, Ramirez-Solis R, Schadt E, Scott J, Shuldiner AR, Smith GD, Smith JG, Snieder H, Sorice R, Spector TD, Stefansson K, Stumvoll M, Tang WH, Toniolo D, Tönjes A, Visscher PM, Vollenweider P, Wareham NJ, Wolffenbuttel BH, Boomsma DI, Beckmann JS, Dedoussis GV, Deloukas P, Ferreira MA, Sanna S, Uda M, Hicks AA, Penninger JM, Gieger C, Kooner JS, Ouwehand WH, Soranzo N, and Chambers JC
Subjects: Animals, Cell Cycle genetics, Cytokines metabolism, Drosophila melanogaster genetics, Erythrocytes cytology, Female, Gene Expression Regulation genetics, Hematopoiesis genetics, Hemoglobins genetics, Humans, Male, Mice, Organ Specificity, Polymorphism, Single Nucleotide genetics, RNA Interference, Signal Transduction genetics, Erythrocytes metabolism, Genetic Loci, Genome-Wide Association Study, Phenotype
Abstract: Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypic variance per trait. Using expression quantitative trait loci and bioinformatic strategies, we identify 121 candidate genes enriched in functions relevant to red blood cell biology. The candidate genes are expressed preferentially in red blood cell precursors, and 43 have haematopoietic phenotypes in Mus musculus or Drosophila melanogaster. Through open-chromatin and coding-variant analyses we identify potential causal genetic variants at 41 loci. Our findings provide extensive new insights into genetic mechanisms and biological pathways controlling red blood cell formation and function.
Published: 2012
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6. Discovery of common variants associated with low TSH levels and thyroid cancer risk.

Author: Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Masson G, He H, Jonasdottir A, Sigurdsson A, Stacey SN, Johannsdottir H, Helgadottir HT, Li W, Nagy R, Ringel MD, Kloos RT, de Visser MC, Plantinga TS, den Heijer M, Aguillo E, Panadero A, Prats E, Garcia-Castaño A, De Juan A, Rivera F, Walters GB, Bjarnason H, Tryggvadottir L, Eyjolfsson GI, Bjornsdottir US, Holm H, Olafsson I, Kristjansson K, Kristvinsson H, Magnusson OT, Thorleifsson G, Gulcher JR, Kong A, Kiemeney LA, Jonsson T, Hjartarson H, Mayordomo JI, Netea-Maier RT, de la Chapelle A, Hrafnkelsson J, Thorsteinsdottir U, Rafnar T, and Stefansson K
Subjects: Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Iceland, Neuregulin-1 blood, Neuregulin-1 genetics, Polymorphism, Single Nucleotide genetics, Chromosomes, Human, Pair 14 genetics, Chromosomes, Human, Pair 2 genetics, Chromosomes, Human, Pair 8 genetics, Genetic Loci genetics, Genetic Predisposition to Disease genetics, Thyroid Neoplasms genetics, Thyrotropin metabolism
Abstract: To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10(-8) in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0.05) were genotyped in an additional 595 non-Icelandic cases and 2,604 controls. After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood.
Published: 2012
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7. Biological, clinical and population relevance of 95 loci for blood lipids.

Author: Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin Cho Y, Jin Go M, Jin Kim Y, Lee JY, Park T, Kim K, Sim X, Twee-Hee Ong R, Croteau-Chonka DC, Lange LA, Smith JD, Song K, Hua Zhao J, Yuan X, Luan J, Lamina C, Ziegler A, Zhang W, Zee RY, Wright AF, Witteman JC, Wilson JF, Willemsen G, Wichmann HE, Whitfield JB, Waterworth DM, Wareham NJ, Waeber G, Vollenweider P, Voight BF, Vitart V, Uitterlinden AG, Uda M, Tuomilehto J, Thompson JR, Tanaka T, Surakka I, Stringham HM, Spector TD, Soranzo N, Smit JH, Sinisalo J, Silander K, Sijbrands EJ, Scuteri A, Scott J, Schlessinger D, Sanna S, Salomaa V, Saharinen J, Sabatti C, Ruokonen A, Rudan I, Rose LM, Roberts R, Rieder M, Psaty BM, Pramstaller PP, Pichler I, Perola M, Penninx BW, Pedersen NL, Pattaro C, Parker AN, Pare G, Oostra BA, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, Meitinger T, McPherson R, McCarthy MI, McArdle W, Masson D, Martin NG, Marroni F, Mangino M, Magnusson PK, Lucas G, Luben R, Loos RJ, Lokki ML, Lettre G, Langenberg C, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, Kronenberg F, König IR, Khaw KT, Kaprio J, Kaplan LM, Johansson A, Jarvelin MR, Janssens AC, Ingelsson E, Igl W, Kees Hovingh G, Hottenga JJ, Hofman A, Hicks AA, Hengstenberg C, Heid IM, Hayward C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Gyllensten U, Guiducci C, Groop LC, Gonzalez E, Gieger C, Freimer NB, Ferrucci L, Erdmann J, Elliott P, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Geus EJ, de Faire U, Crawford G, Collins FS, Chen YD, Caulfield MJ, Campbell H, Burtt NP, Bonnycastle LL, Boomsma DI, Boekholdt SM, Bergman RN, Barroso I, Bandinelli S, Ballantyne CM, Assimes TL, Quertermous T, Altshuler D, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Adair LS, Taylor HA Jr, Borecki IB, Gabriel SB, Wilson JG, Holm H, Thorsteinsdottir U, Gudnason V, Krauss RM, Mohlke KL, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Schadt EE, Rotter JI, Boerwinkle E, Strachan DP, Mooser V, Stefansson K, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, van Duijn CM, Peltonen L, Abecasis GR, Boehnke M, and Kathiresan S
Subjects: Black or African American genetics, Animals, Asian People genetics, Cholesterol, HDL blood, Cholesterol, LDL blood, Coronary Artery Disease blood, Coronary Artery Disease genetics, Coronary Artery Disease therapy, Europe ethnology, Female, Genotype, Humans, Liver metabolism, Male, Mice, N-Acetylgalactosaminyltransferases genetics, N-Acetylgalactosaminyltransferases metabolism, Phenotype, Polymorphism, Single Nucleotide genetics, Protein Phosphatase 1 genetics, Protein Phosphatase 1 metabolism, Reproducibility of Results, Triglycerides blood, White People genetics, Polypeptide N-acetylgalactosaminyltransferase, Genetic Loci genetics, Genome-Wide Association Study, Lipid Metabolism genetics, Lipids blood
Abstract: Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Published: 2010
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8. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Author: Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, van der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan JL, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko PJ, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent WV, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, and Loeffler, Markus
Subjects: Animals, Humans, Drosophila melanogaster, Albuminuria, Diabetes Mellitus, Genetic Predisposition to Disease, Creatinine, Risk Factors, Chromosome Mapping, Gene Expression Regulation, Meta-Analysis as Topic, Genome-Wide Association Study, Genetic Loci, Phenomics
Abstract: Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.
Published: 2019

9. Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci

Author: Ghouse, Jonas, Tragante, Vinicius, Muhammad, Ayesha, Ahlberg, Gustav, Skov, Morten W., Roden, Dan M., Jonsdottir, Ingileif, Andreasen, Laura, Lundegaard, Pia Rengtved, Trudsø, Linea C., Banasik, Karina, Brunak, Søren, Ostrowski, Sisse R., Torp-Pedersen, Christian, Pedersen, Ole V., Sørensen, Erik, Køber, Lars, Iversen, Kasper, Thorsteinsdottir, Unnur, Thorgeirsson, Gudmundur, Ullum, Henrik, Gudbjartsson, Daniel F., Mosley, Jonathan D., Holm, Hilma, Stefansson, Kari, Bundgaard, Henning, and Olesen, Morten Salling
Subjects: Genome-wide association study, ACE inhibitors, ADR, Drug discontinuation, Adverse drug reaction, Angiotensin-Converting Enzyme Inhibitors, ACE-inhibitor associated cough, Cough, Clinical Research, Genetic Loci, Risk Factors, Humans, GWAS, Precision Medicine, Angioedema, Cardiology and Cardiovascular Medicine, Genome-Wide Association Study
Abstract: Aims To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs). Methods and results A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker. Controls were defined as persons who continued ACEi treatment for at least 1 year. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were computed for ACEi discontinuation risk by mixed model regression analysis. Summary statistics from the individual cohorts were meta-analyzed with a fixed-effects model. To test for association with specific ACEi-associated ADRs, any genome-wide significant (P < 5 × 10-8) ACEi discontinuation variants was tested for association with ACEi-associated cough and angioedema. A polygenetic risk score (PRS) based on ACEi discontinuation GWAS data was constructed and tested for association with ACEi-associated cough and angioedema in two population-based samples. In total, seven genetic genome-wide loci were identified, of which six were previously unreported. The strongest association with ACEi discontinuation was at 20q13.3 (NTSR1; OR: 1.21; 95% CI: 1.17–1.24; P = 2.1 × 10–34). Five of seven lead variants were associated with ACEi-associated cough, whereas none were associated with ACEi-associated angioedema. The ACEi discontinuation PRS was associated with ACEi-associated cough in a dose–response manner but not with ACEi-associated angioedema. ACEi discontinuation was genetically correlated with important causes for cough, including gastro-esophageal reflux disease, allergic rhinitis, hay fever, and asthma, which indicates partly shared genetic underpinning between these traits. Conclusion This study showed the advantage of using prescription patterns to discover genetic links with ADRs. In total, seven genetic loci that associated with ACEi discontinuation were identified. There was evidence of a strong association between our ADR phenotype and ACEi-associated cough. Taken together, these findings increase insight into the pathophysiological processes that underlie ACEi-associated ADRs.
Published: 2022

10. Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Author: Gorski, Mathias, Rasheed, Humaira, Teumer, Alexander, Thomas, Laurent F., Graham, Sarah E, Sveinbjornsson, Gardar, Winkler, Thomas W., Günther, Felix, Stark, Klaus J., Chai, Jin-Fang, Tayo, Bamidele O., Wuttke, Matthias, Li, Yong, Tin, Adrienne, Ahluwalia, Tarunveer S., Ärnlöv, Johan, Åsvold, Bjørn Olav, Bakker, Stephan J.L., Banas, Bernhard, Bansal, Nisha, Biggs, Mary L., Biino, Ginevra, Böhnke, Michael, Boerwinkle, Eric, Bottinger, Erwin P., Brenner, Hermann, Brumpton, Ben, Carroll, Robert J., Chaker, Layal, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Chu, Audrey Y., Ciullo, Marina, Cocca, Massimiliano, Cook, James P., Coresh, Josef, Cusi, Daniele, de Borst, Martin H., Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Evans, Michele K., Feitosa, Mary F., Franke, Andre, Freitag-Wolf, Sandra, Fuchsberger, Christian, Gampawar, Piyush, Gansevoort, Ron T., Ghanbari, Mohsen, Ghasemi, Sahar, Giedraitis, Vilmantas, Gieger, Christian, Gudbjartsson, Daniel F., Hallan, Stein, Hamet, Pavel, Hishida, Asahi, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Holm, Hilma, Hoppmann, Anselm, Horn, Katrin, Hutri-Kähönen, Nina, Hveem, Kristian, Hwang, Shih-Jen, Ikram, M. Arfan, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Karabegović, Irma, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kühnel, Brigitte, Kuusisto, Johanna, Laakso, Markku, Lange, Leslie A., Lehtimäki, Terho, Li, Man, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M., Loos, Ruth J.F., Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Matias-Garcia, Pamela R., Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Morris, Andrew P., Mychaleckyj, Josyf C., Nadkarni, Girish N., Naito, Mariko, Nakatochi, Masahiro, Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., Nutile, Teresa, O’Donoghue, Michelle L., O'Connell, Jeffrey R., Olafsson, Isleifur, Orho-Melander, Marju, Parsa, Afshin, Pendergrass, Sarah A., Penninx, Brenda W.J.H., Pirastu, Mario, Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Raitakari, Olli T., Rheinberger, Myriam, Rice, Kenneth M., Rizzi, Federica, Rosenkranz, Alexander R., Rossing, Peter, Rotter, Jerome I., Ruggiero, Daniela, Ryan, Kathleen A., Sabanayagam, Charumathi, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Scholz, Markus, Schöttker, Ben, Schulz, Christina-Alexandra, Sedaghat, Sanaz, Shaffer, Christian M., Sieber, Karsten B., Sim, Xueling, Sims, Mario, Snieder, Harold, Stanzick, Kira J., Thorsteinsdottir, Unnur, Stocker, Hannah, Strauch, Konstantin, Stringham, Heather M., Sulem, Patrick, Szymczak, Silke, Taylor, Kent D., Thio, Chris H.L., Tremblay, Johanne, Vaccargiu, Simona, van der Harst, Pim, van der Most, Peter J., Verweij, Niek, Völker, Uwe, Wakai, Kenji, Waldenberger, Melanie, Wallentin, Lars, Wallner, Stefan, Wang, Judy, Waterworth, Dawn M., White, Harvey D., Willer, Cristen J., Wong, Tien-Yin, Woodward, Mark, Yang, Qiong, Yerges-Armstrong, Laura M., Zimmermann, Martina E., Zonderman, Alan B., Bergler, Tobias, Stefansson, Kari, Böger, Carsten A., Pattaro, Cristian, Köttgen, Anna, Kronenberg, Florian, Heid, Iris M., Tampere University, Clinical Medicine, Department of Paediatrics, Department of Clinical Physiology and Nuclear Medicine, Department of Clinical Chemistry, TAYS Heart Centre, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, APH - Mental Health, APH - Digital Health, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Life Course Epidemiology (LCE), Internal Medicine, and Epidemiology
Subjects: acute kidney injury, chronic kidney disease, diabetes, gene expression, 610 Medizin, Kidney, Urologi och njurmedicin, Humans, Urology and Nephrology, ddc:610, Longitudinal Studies, Renal Insufficiency, Renal Insufficiency, Chronic, Medicinsk genetik, diabetes, Public Health, Global Health, Social Medicine and Epidemiology, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Cross-Sectional Studies, acute kidney injury, Genetic Loci, Nephrology, gene expression, N-Acetylgalactosaminyltransferases, 3111 Biomedicine, Medical Genetics, chronic kidney disease, Genome-Wide Association Study, Glomerular Filtration Rate
Abstract: Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant-by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with age-dependency of genetic cross-section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in-silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03-1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics. publishedVersion
Published: 2022

11. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author: Wain, Louise V, Verwoert, Germaine C, O'Reilly, Paul F, Shi, Gang, Johnson, Toby, Johnson, Andrew D, Bochud, Murielle, Rice, Kenneth M, Henneman, Peter, Smith, Albert V, Ehret, Georg B, Amin, Najaf, Larson, Martin G, Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile JW, Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'an, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U, Webster, Rebecca J, Zhang, Feng, Peden, John F, Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I, Trompet, Stella, Bragg-Gresham, Jennifer L, Alizadeh, Behrooz Z, Chambers, John C, Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M, Polašek, Ozren, Boban, Mladen, Nelson, Christopher P, Morrison, Alanna C, Pihur, Vasyl, Ganesh, Santhi K, Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco US, Rivadeneira, Fernando, Sijbrands, Eric JG, Uitterlinden, Andre G, Hwang, Shih-Jen, Vasan, Ramachandran S, Wang, Thomas J, Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L, Kroemer, Heyo K, Völker, Uwe, Völzke, Henry, Glazer, Nicole L, Taylor, Kent D, Harris, Tamara B, Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, Inês, Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M, Penninx, Brenda W, Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco, Fabiola M, Facheris, Maurizio, Collins, Francis S, Bergman, Richard N, Beilby, John P, Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S, Navarro, Pau, Wild, Sarah H, Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco JC, Willemsen, Gonneke, Parker, Alex N, Rose, Lynda M, Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, LifeLines Cohort Study, Van Der Klauw, Melanie M, Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M, Emilsson, Valur, Plump, Andrew, Lindeman, Jan H, Hoen, Peter AC 'T, König, Inke R, EchoGen Consortium, Felix, Janine F, Clarke, Robert, Hopewell, Jemma C, Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L, Fornage, Myriam, AortaGen Consortium, Mitchell, Gary F, CHARGE Consortium Heart Failure Working Group, Smith, Nicholas L, KidneyGen Consortium, Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, CKDGen Consortium, Cardiogenics Consortium, CardioGram, Samani, Nilesh J, Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J, Wichmann, H-Erich, Raitakari, Olli T, Palmas, Walter, Kooner, Jaspal S, Stolk, Ronald P, Jukema, J Wouter, Wright, Alan F, Boomsma, Dorret I, Bandinelli, Stefania, Gyllensten, Ulf B, Wilson, James F, Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D, Palmer, Lyle J, Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth JF, Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J, Oostra, Ben A, Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P, Beckmann, Jacques S, Witteman, Jacqueline CM, Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M, Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R, Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B, Psaty, Bruce M, Caulfield, Mark J, Rao, Dabeeru C, Tobin, Martin D, Elliott, Paul, and Van Duijn, Cornelia M
Subjects: Genetic Loci, Case-Control Studies, Hypertension, Humans, Blood Pressure, cardiovascular diseases, Arteries, Polymorphism, Single Nucleotide, Linkage Disequilibrium, circulatory and respiratory physiology, Follow-Up Studies, Genome-Wide Association Study
Abstract: Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Published: 2018
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12. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author: Wain, Louise V., Verwoert, Germaine C., O'Reilly, Paul F., Shi, Gang, Johnson, Toby, Johnson, Andrew D., Bochud, Murielle, Rice, Kenneth M., Henneman, Peter, Smith, Albert V., Ehret, Georg B., Amin, Najaf, Larson, Martin G., Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J. W., Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'An, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U., Webster, Rebecca J., Zhang, Feng, Peden, John F., Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I., Trompet, Stella, Bragg-Gresham, Jennifer L., Alizadeh, Behrooz Z., Chambers, John C., Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M., Polašek, Ozren, Boban, Mladen, Nelson, Christopher P., Morrison, Alanna C., Pihur, Vasyl, Ganesh, Santhi K., Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U. S., Rivadeneira, Fernando, Sijbrands, Eric J. G., Uitterlinden, Andre G., Hwang, Shih-Jen, Vasan, Ramachandran S., Wang, Thomas J., Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L., Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Glazer, Nicole L., Taylor, Kent D., Harris, Tamara B., Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, In S., Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M., Penninx, Brenda W., Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S., Bergman, Richard N., Beilby, John P., Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S., Navarro, Pau, Wild, Sarah H., Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco J. C., Willemsen, Gonneke, Parker, Alex N., Rose, Lynda M., Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, Van Der Klauw, Melanie M., Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M., Emilsson, Valur, Plump, Andrew, Lindeman, Jan H., Hoen, Peter A. C. T., König, Inke R., Felix, Janine F., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L., Fornage, Myriam, Mitchell, Gary F., Smith, Nicholas L., Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J., Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J., Wichmann, H-Erich, Raitakari, Olli T., Palmas, Walter, Kooner, Jaspal S., Stolk, Ronald P., Jukema, J Wouter, Wright, Alan F., Boomsma, Dorret I., Bandinelli, Stefania, Gyllensten, Ulf B., Wilson, James F., Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D., Palmer, Lyle J., Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth J. F., Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J., Oostra, Ben A., Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P., Beckmann, Jacques S., Witteman, Jacqueline C. M., Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M., Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R., Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B., Psaty, Bruce M., Caulfield, Mark J., Rao, Dabeeru C., Tobin, Martin D., Elliott, Paul, Van Duijn, Cornelia M. McEniery CM, Wilkinson IB, Cockcroft JR, O'Shaughnessy KM, Newhouse SJ, Yasmin, Smith AV, Eiriksdottir G, Launer LJ, Sigurdsson S, Aspelund T, Gudnason V, De Bacquer D, Rietzschel ER, De Backer GG, Van Bortel L, De Buyzere ML, Segers P, Bekaert S, Gillebert TC, De Meyer T, Ferrucci L, Tanaka T, Johnson AD, Levy D, Benjamin EJ, Mitchell GF, Vita JA, Larson MG, Hamburg NM, Vasan RS, Isaacs A, Schut AF, Oostra BA, van Duijn CM, van Rijn MJ, Sie MP, Newman AB, Herrington DM, Andrews JS, Ding J, Sutton-Tyrrell KC, Harris TB, Howard TD, Liu Y, Parsa A, Shuldiner AR, McArdle PF, Gibson Q, Post WS, Dehghan A, Hofman A, Uitterlinden AG, Sijbrands EJ, Rivadeneira F, Mattace-Raso FU, Verwoert GC, Witteman JC, Scuteri A, Lakatta EG, Jewell E, Abecasis GR, Tarasov KV, Uda M, Najjar SS, Sanna S, Attwood T, Belz S, Braund P, Cambien F, Cooper J, Crisp-Hihn A, Deloukas P, Foad N, Eardman J, Goodall AH, Gracey J, Gray E, Gulde S, Gwilliams R, Heimerl S, Hengstenberg C, Jolley J, Krishnan U, Linsel-Nitschke P, Lloyd-Jones H, Lugauer I, Lundmark P, Maouche S, Moore JS, Muir D, Murray E, Nelson CP, Neudert J, Niblett D, O'Leary K, Ouwehand WH, Pollard H, Rankin A, Rice CM, Sager H, Samani NJ, Sambrook J, Schmitz G, Scholz M, Schroeder L, Schunkert H, Syvannen AC, Wallace C, Kathiresan S, Reilly MP, Erdmann J, Assimes TL, Boerwinkle E, Hall A, König IR, Laaksonen R, McPherson R, Thompson JR, Thorsteinsdottir U, Ziegler A, Absher D, Chen L, Cupples LA, Halperin E, Li M, Musunuru K, Preuss M, Schillert A, Thorleifsson G, Voight BF, Wells GA, Assime TL, Holm H, Roberts R, Stewart AF, Fortmann S, Go A, Hlatky M, Iribarren C, Knowles J, Myers R, Quertermous T, Sidney S, Risch N, Tang H, Blankenberg S, Zeller T, Wild P, Schnabel R, Sinning C, Lackner K, Tiret L, Nicaud V, Bickel C, Rupprecht HJ, Perret C, Proust C, Münzel T, Barbalic M, Bis J, Chen IY, Cupples L, Demissie-Banjaw S, Folsom A, Glazer N, Harris T, Heckbert S, Lumley T, Marciante K, Morrison A, O' Donnell CJ, Psaty BM, Rice K, Rotter JI, Siscovick DS, Smith N, Smith A, Taylor KD, van Duijn C, Volcik K, Whitteman J, Ramachandran V, Uitterlinden A, Gretarsdottir S, Gulcher JR, Kong A, Stefansson K, Thorgeirsson G, Andersen K, Fischer M, Grosshennig A, Lieb W, Stark K, Schreiber S, Wichmann HE, Aherrahrou Z, Bruse P, Doering A, Illig T, Klopp N, Loley C, Medack A, Meisinger C, Meitinger T, Nahrstedt J, Peters A, Wagner AK, Willenborg C, Böhm BO, Dobnig H, Grammer TB, Hoffmann MM, Kleber M, März W, Meinitzer A, Winkelmann BR, Pilz S, Renner W, Scharnagl H, Stojakovic T, Tomaschitz A, Winkler K, Guiducci C, Burtt N, Gabriel SB, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Dandona S, Jarinova O, Qu L, Wilensky R, Matthai W, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser V, Epstein SE, Rader DJ, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS, Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Rosamond WD, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Yang YA, Stricker BH, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Heckbert SR, Fox ER, Willerson JT, Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Gao X, Yang Q, O'Connell JR, Schmidt H, Ketkar S, Hwang SJ, Teumer A, Paré G, Atkinson EJ, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Rampersaud E, Mitchell BD, Arking DE, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Siscovick D, Zillikens MC, Feitosa M, Province M, de Andrade M, Turner ST, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Coresh J, Schmidt R, Shlipak MG, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS, Felix SB, Watzinger N, Homuth G, Aragam J, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Deckers JW, Stritzke J, Lackner KJ, Ingelsson E, Kullo I, Haerting J, Reffelmann T, Redfield MM, Werdan K, Arnett DK, Blettner M, Friedrich N, Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Munroe PB, Nordfors L, Penninx BW, Perucha E, Pouta A, Roderick PJ, Ruokonen A, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Ubink-Veltmaat LJ, Vollenweider P, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS., Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), University of Leicester, Department of Genetics [Leicester], Erasmus University Rotterdam, Netherlands Genomics Initiative, Department of Epidemiology and Biostatistics, School of Public Health, Zahedan University of Medical Sciences, Washington University in Saint Louis (WUSTL), Queen Mary University of London (QMUL), National Heart, Lung and Blood Institute, Partenaires INRAE, Centre Hospitalier Universitaire Vaudois (CHUV), Université de Lausanne = University of Lausanne (UNIL), Department of Biostatistics [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Leiden University Medical Center (LUMC), Universiteit Leiden, Icelandic Heart Association, Heart Preventive Clinic and Research Institute, University of Iceland [Reykjavik], Johns Hopkins University, School of Medicine, Hôpitaux Universitaires de Genève (HUG), Department of Epidemiology, The Netherlands Cancer Institute, Department of Mathematics, Boston University [Boston] (BU), GlaxoSmithKline, Division of Community Health Sciences, St. George's, University of South Florida [Tampa] (USF), Universität Greifswald - University of Greifswald, University of Washington [Seattle], University of Tartu, Institute of Molecular and Cell Biology, Medical Research Council, Institut de Génomique, Centre National de Génotypage, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University Medical Center Groningen, Department of Genetics, University Medical Center Groningen [Groningen] (UMCG), Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Massachusetts General Hospital [Boston], Centro de Regulación Genómica (CRG), Universitat Pompeu Fabra [Barcelona] (UPF), Università degli studi di Trieste = University of Trieste, Universität zu Lübeck = University of Lübeck [Lübeck], Department of Biostatistics, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, The University of Western Australia (UWA), Department of Twin Research and Genetic Epidemiology, King's College London, London, University of Oxford, Medical University Graz, National Institute on Aging, Centre for population Health Sciences, University of Edinburgh, Uppsala University, Vrije Universiteit Amsterdam [Amsterdam] (VU), Western General Hospital, Harvard Medical School [Boston] (HMS), Brigham and Women's Hospital [Boston], University of Michigan System, University of Groningen, Ealing Hospital, School of Public Health - Department of Epidemiology and Biostatistics, Imperial College London, Medical Genetics Institute, Cedars-Sinai Medical Center, University of Tampere, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Split, The University of Texas Health Science Center at Houston (UTHealth), Johns Hopkins University (JHU), Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), Swiss Institute of Bioinformatics [Lausanne] (SIB), Finnish Institute of Occupational Health, National Institute of Health and Welfare, University of Oulu, Lapland Central Hospital, University of Bristol [Bristol], Institute for Community Medicine, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), US National Institutes of Health, National Heart, Lung, and Blood Institute, European, Epidemiology, Internal Medicine, Public Health, Clinical Genetics, Université de Lausanne (UNIL), LeidenUniversity Medical Centre, University of Iceland, Università degli studi di Trieste, Universität zu Lübeck [Lübeck], University of Western Australia, University of Oxford [Oxford], VU University Amsterdam, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Human genetics, Psychiatry, EMGO - Mental health, NCA - Anxiety & Depression, Epidemiology and Data Science, Medical Research Council (MRC), Louise V., Wain, Germaine C., Verwoert, Paul F., O'Reilly, Gang, Shi, Toby, Johnson, Andrew D., Johnson, Murielle, Bochud, Kenneth M., Rice, Peter, Henneman, Albert V., Smith, Georg B., Ehret, Najaf, Amin, Martin G., Larson, Vincent, Mooser, David, Hadley, Marcus, Dörr, Joshua C., Bi, Thor, Aspelund, Tõnu, Esko, A. Cecile J. W., Janssen, Jing Hua, Zhao, Simon, Heath, Maris, Laan, Jingyuan, Fu, Giorgio, Pisti, Jian'An, Luan, Pankaj, Arora, Gavin, Luca, Pirastu, Nicola, Irene, Pichler, Anne U., Jackson, Rebecca J., Webster, Feng, Zhang, John F., Peden, Helena, Schmidt, Toshiko, Tanaka, Harry, Campbell, Wilmar, Igl, Yuri, Milaneschi, Jouke Jan, Hottenga, Veronique, Vitart, Daniel I., Chasman, Stella, Trompet, Jennifer L., Bragg Gresham, Behrooz Z., Alizadeh, John C., Chamber, Xiuqing, Guo, Terho, Lehtimäki, Brigitte, Kühnel, Lorna M., Lopez, Ozren, Polašek, Mladen, Boban, Christopher P., Nelson, Alanna C., Morrison, Vasyl, Pihur, Santhi K., Ganesh, Albert, Hofman, Suman, Kundu, Francesco U. S., Mattace Raso, Fernando, Rivadeneira, Eric J. G., Sijbrand, Andre G., Uitterlinden, Shih Jen, Hwang, Ramachandran S., Vasan, Thomas J., Wang, Sven, Bergmann, Peter, Vollenweider, Gérard, Waeber, Jaana, Laitinen, Anneli, Pouta, Paavo, Zitting, Wendy L., Mcardle, Heyo K., Kroemer, Uwe, Völker, Henry, Völzke, Nicole L., Glazer, Kent D., Taylor, Tamara B., Harri, Helene, Alavere, Toomas, Haller, Aime, Kei, Mari Liis, Tammesoo, Yurii, Aulchenko, Inês, Barroso, Kay Tee, Khaw, Pilar, Galan, Serge, Hercberg, Mark, Lathrop, Susana, Eyheramendy, Elin, Org, Siim, Sõber, Xiaowen, Lu, Ilja M., Nolte, Brenda W., Penninx, Tanguy, Corre, Corrado, Masciullo, Cinzia, Sala, Leif, Groop, Benjamin F., Voight, Olle, Melander, Christopher J., O'Donnell, Veikko, Salomaa, D'Adamo, ADAMO PIO, Antonella, Fabretto, Flavio, Faletra, Sheila, Ulivi, Fabiola Del Greco, M, Maurizio, Facheri, Francis S., Collin, Richard N., Bergman, John P., Beilby, Joseph, Hung, A., William Musk, Massimo, Mangino, So Youn, Shin, Nicole, Soranzo, Hugh, Watkin, Anuj, Goel, Anders, Hamsten, Pierre, Gider, Marisa, Loitfelder, Marion, Zeginigg, Dena, Hernandez, Samer S., Najjar, Pau, Navarro, Sarah H., Wild, Anna Maria, Corsi, Andrew, Singleton, Eco J. C., de Geu, Gonneke, Willemsen, Alex N., Parker, Lynda M., Rose, Brendan, Buckley, David, Stott, Marco, Orru, Manuela, Uda, Melanie M., van der Klauw, Weihua, Zhang, Xinzhong, Li, James, Scott, Yii Der Ida, Chen, Gregory L., Burke, Mika, Kähönen, Jorma, Viikari, Angela, Döring, Thomas, Meitinger, Gail, Davie, John M., Starr, Valur, Emilsson, Andrew, Plump, Jan H., Lindeman, Peter A. C., 't Hoen, Inke R., König, Janine F., Felix, Robert, Clarke, Jemma C., Hopewell, Halit, Ongen, Monique, Breteler, Stéphanie, Debette, Anita L., Destefano, Myriam, Fornage, Gary F., Mitchell, Nicholas L., Smith, Hilma, Holm, Kari, Stefansson, Gudmar, Thorleifsson, Unnur, Thorsteinsdottir, Nilesh J., Samani, Michael, Preu, Igor, Rudan, Caroline, Hayward, Ian J., Deary, H., Erich Wichmann, Olli T., Raitakari, Walter, Palma, Jaspal S., Kooner, Ronald P., Stolk, J., Wouter Jukema, Alan F., Wright, Dorret I., Boomsma, Stefania, Bandinelli, Ulf B., Gyllensten, James F., Wilson, Luigi, Ferrucci, Reinhold, Schmidt, Martin, Farrall, Tim D., Spector, Lyle J., Palmer, Jaakko, Tuomilehto, Arne, Pfeufer, Gasparini, Paolo, David, Siscovick, David, Altshuler, Ruth J. F., Loo, Daniela, Toniolo, Harold, Snieder, Christian, Gieger, Pierre, Meneton, Nicholas J., Wareham, Ben A., Oostra, Andres, Metspalu, Lenore, Launer, Rainer, Rettig, David P., Strachan, Jacques S., Beckmann, Jacqueline C. M., Witteman, Jeanette, Erdmann, Ko Willems van, Dijk, Eric, Boerwinkle, Michael, Boehnke, Paul M., Ridker, Marjo Riitta, Jarvelin, Aravinda, Chakravarti, Goncalo R., Abecasi, Vilmundur, Gudnason, Christopher Newton, Cheh, Daniel, Levy, Patricia B., Munroe, Bruce M., Psaty, Mark J., Caulfield, Dabeeru C., Rao, Martin D., Tobin, Paul, Elliott, Cornelia M., van Duijn, Biological Psychology, Neuroscience Campus Amsterdam - Anxiety & Depression, EMGO+ - Mental Health, Wain, Louise V., Verwoert, Germaine C., O'Reilly, Paul F., Shi, Gang, Johnson, Toby, Johnson, Andrew D., Bochud, Murielle, Rice, Kenneth M., Henneman, Peter, Smith, Albert V., Ehret, Georg B., Amin, Najaf, Larson, Martin G., Mooser, Vincent, Hadley, David, Dörr, Marcu, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J. W., Zhao, Jing Hua, Heath, Simon, Laan, Mari, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'An, Arora, Pankaj, Lucas, Gavin, Pichler, Irene, Jackson, Anne U., Webster, Rebecca J., Zhang, Feng, Peden, John F., Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I., Trompet, Stella, Bragg-Gresham, Jennifer L., Alizadeh, Behrooz Z., Chambers, John C., Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M., Polašek, Ozren, Boban, Mladen, Nelson, Christopher P., Morrison, Alanna C., Pihur, Vasyl, Ganesh, Santhi K., Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U. S., Rivadeneira, Fernando, Sijbrands, Eric J. G., Uitterlinden, Andre G., Hwang, Shih-Jen, Vasan, Ramachandran S., Wang, Thomas J., Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, Mcardle, Wendy L., Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Glazer, Nicole L., Taylor, Kent D., Harris, Tamara B., Alavere, Helene, Haller, Tooma, Keis, Aime, Tammesoo, Mari-Lii, Aulchenko, Yurii, Barroso, In S., Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M., Penninx, Brenda W., Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S., Bergman, Richard N., Beilby, John P., Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Ander, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S., Navarro, Pau, Wild, Sarah H., Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco J. C., Willemsen, Gonneke, Parker, Alex N., Rose, Lynda M., Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, Van Der Klauw, Melanie M., Zhang, Weihua, Li, Xinzhong, Scott, Jame, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thoma, Davies, Gail, Starr, John M., Emilsson, Valur, Plump, Andrew, Lindeman, Jan H., Hoen, Peter A. C. T., König, Inke R., Felix, Janine F., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L., Fornage, Myriam, Mitchell, Gary F., Smith, Nicholas L., Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J., Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J., Wichmann, H-Erich, Raitakari, Olli T., Palmas, Walter, Kooner, Jaspal S., Stolk, Ronald P., Jukema, J Wouter, Wright, Alan F., Boomsma, Dorret I., Bandinelli, Stefania, Gyllensten, Ulf B., Wilson, James F., Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D., Palmer, Lyle J., Tuomilehto, Jaakko, Pfeufer, Arne, Siscovick, David, Altshuler, David, Loos, Ruth J. F., Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J., Oostra, Ben A., Metspalu, Andre, Launer, Lenore, Rettig, Rainer, Strachan, David P., Beckmann, Jacques S., Witteman, Jacqueline C. M., Erdmann, Jeanette, Van Dijk, Ko Willem, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M., Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R., Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B., Psaty, Bruce M., Caulfield, Mark J., Rao, Dabeeru C., Tobin, Martin D., Elliott, Paul, Van, Duijn, Cornelia M., McEniery CM, Wilkinson, Ib, Cockcroft, Jr, O'Shaughnessy, Km, Newhouse, Sj, Yasmin, Smith, Av, Eiriksdottir, G, Launer, Lj, Sigurdsson, S, Aspelund, T, Gudnason, V, De Bacquer, D, Rietzschel, Er, De Backer, Gg, Van Bortel, L, De Buyzere, Ml, Segers, P, Bekaert, S, Gillebert, Tc, De Meyer, T, Ferrucci, L, Tanaka, T, Johnson, Ad, Levy, D, Benjamin, Ej, Mitchell, Gf, Vita, Ja, Larson, Mg, Hamburg, Nm, Vasan, R, Isaacs, A, Schut, Af, Oostra, Ba, van Duijn, Cm, van Rijn, Mj, Sie, Mp, Newman, Ab, Herrington, Dm, Andrews, J, Ding, J, Sutton-Tyrrell, Kc, Harris, Tb, Howard, Td, Liu, Y, Parsa, A, Shuldiner, Ar, Mcardle, Pf, Gibson, Q, Post, W, Dehghan, A, Hofman, A, Uitterlinden, Ag, Sijbrands, Ej, Rivadeneira, F, Mattace-Raso, Fu, Verwoert, Gc, Witteman, Jc, Scuteri, A, Lakatta, Eg, Jewell, E, Abecasis, Gr, Tarasov, Kv, Uda, M, Najjar, S, Sanna, S, Attwood, T, Belz, S, Braund, P, Cambien, F, Cooper, J, Crisp-Hihn, A, Deloukas, P, Foad, N, Eardman, J, Goodall, Ah, Gracey, J, Gray, E, Gulde, S, Gwilliams, R, Heimerl, S, Hengstenberg, C, Jolley, J, Krishnan, U, Linsel-Nitschke, P, Lloyd-Jones, H, Lugauer, I, Lundmark, P, Maouche, S, Moore, J, Muir, D, Murray, E, Nelson, Cp, Neudert, J, Niblett, D, O'Leary, K, Ouwehand, Wh, Pollard, H, Rankin, A, Rice, Cm, Sager, H, Samani, Nj, Sambrook, J, Schmitz, G, Scholz, M, Schroeder, L, Schunkert, H, Syvannen, Ac, Wallace, C, Kathiresan, S, Reilly, Mp, Erdmann, J, Assimes, Tl, Boerwinkle, E, Hall, A, König, Ir, Laaksonen, R, Mcpherson, R, Thompson, Jr, Thorsteinsdottir, U, Ziegler, A, Absher, D, Chen, L, Cupples, La, Halperin, E, Li, M, Musunuru, K, Preuss, M, Schillert, A, Thorleifsson, G, Voight, Bf, Wells, Ga, Assime, Tl, Holm, H, Roberts, R, Stewart, Af, Fortmann, S, Go, A, Hlatky, M, Iribarren, C, Knowles, J, Myers, R, Quertermous, T, Sidney, S, Risch, N, Tang, H, Blankenberg, S, Zeller, T, Wild, P, Schnabel, R, Sinning, C, Lackner, K, Tiret, L, Nicaud, V, Bickel, C, Rupprecht, Hj, Perret, C, Proust, C, Münzel, T, Barbalic, M, Bis, J, Chen, Iy, Cupples, L, Demissie-Banjaw, S, Folsom, A, Glazer, N, Harris, T, Heckbert, S, Lumley, T, Marciante, K, Morrison, A, O' Donnell, Cj, Psaty, Bm, Rice, K, Rotter, Ji, Siscovick, D, Smith, N, Smith, A, Taylor, Kd, van Duijn, C, Volcik, K, Whitteman, J, Ramachandran, V, Uitterlinden, A, Gretarsdottir, S, Gulcher, Jr, Kong, A, Stefansson, K, Thorgeirsson, G, Andersen, K, Fischer, M, Grosshennig, A, Lieb, W, Stark, K, Schreiber, S, Wichmann, He, Aherrahrou, Z, Bruse, P, Doering, A, Illig, T, Klopp, N, Loley, C, Medack, A, Meisinger, C, Meitinger, T, Nahrstedt, J, Peters, A, Wagner, Ak, Willenborg, C, Böhm, Bo, Dobnig, H, Grammer, Tb, Hoffmann, Mm, Kleber, M, März, W, Meinitzer, A, Winkelmann, Br, Pilz, S, Renner, W, Scharnagl, H, Stojakovic, T, Tomaschitz, A, Winkler, K, Guiducci, C, Burtt, N, Gabriel, Sb, O'Donnell, Cj, Elosua, R, Peltonen, L, Salomaa, V, Schwartz, Sm, Melander, O, Altshuler, D, Dandona, S, Jarinova, O, Qu, L, Wilensky, R, Matthai, W, Hakonarson, Hh, Devaney, J, Burnett, M, Pichard, Ad, Kent, Km, Satler, L, Lindsay, Jm, Waksman, R, Knouff, Cw, Waterworth, Dm, Walker, Mc, Mooser, V, Epstein, Se, Rader, Dj, Wright, Bj, Balmforth, Aj, Ball, Sg, Smith, Nl, Felix, Jf, Morrison, Ac, Demissie, S, Glazer, Nl, Loehr, Lr, Rosamond, Wd, Bis, Jc, Folsom, Ar, Benjamin, E, Aulchenko, Y, Haritunians, T, Couper, D, Murabito, J, Yang, Ya, Stricker, Bh, Gottdiener, J, Chang, Pp, Wang, Tj, Rice, Km, Heckbert, Sr, Fox, Er, Willerson, Jt, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Gao, X, Yang, Q, O'Connell, Jr, Schmidt, H, Ketkar, S, Hwang, Sj, Teumer, A, Paré, G, Atkinson, Ej, Lohman, K, Cornelis, Mc, Probst-Hensch, Nm, Kronenberg, F, Tönjes, A, Hayward, C, Rampersaud, E, Mitchell, Bd, Arking, De, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer, Ih, Zillikens, Mc, Feitosa, M, Province, M, de Andrade, M, Turner, St, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, T, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, A, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Coresh, J, Schmidt, R, Shlipak, Mg, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, C, Felix, Sb, Watzinger, N, Homuth, G, Aragam, J, Dörr, M, Zweiker, R, Lind, L, Rodeheffer, Rj, Greiser, Kh, Deckers, Jw, Stritzke, J, Lackner, Kj, Ingelsson, E, Kullo, I, Haerting, J, Reffelmann, T, Redfield, Mm, Werdan, K, Arnett, Dk, Blettner, M, Friedrich, N, Chambers, Jc, Zhang, W, Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, J, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Davey Smith, G, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, Homan van der Heide, Jj, Hepkema, Bg, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, Pe, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Munroe, Pb, Nordfors, L, Penninx, Bw, Perucha, E, Pouta, A, Roderick, Pj, Ruokonen, A, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Ubink-Veltmaat, Lj, Vollenweider, P, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Lightstone, L, Scott, J, Navis, G, Elliott, P, and Kooner, Js.
Subjects: Netherlands Twin Register (NTR), Linkage disequilibrium, pulse pressure, mean arterial pressure, genome-wide, [SDV]Life Sciences [q-bio], Genome-wide association study, BLOOD-PRESSURE, Blood Pressure, 030204 cardiovascular system & hematology, Linkage Disequilibrium, 0302 clinical medicine, RELEVANCE, CardioGram, Medicine and Health Sciences, Genetics & Heredity, ddc:616, Genetics, 0303 health sciences, Genome-wide association, 11 Medical And Health Sciences, Arteries, ADRENERGIC-RECEPTOR TRAFFICKING, Pulse pressure, EchoGen consortium, Hypertension, HEART-FAILURE, arterial pressure, Case-Control Studie, Life Sciences & Biomedicine, Human, circulatory and respiratory physiology, medicine.medical_specialty, Mean arterial pressure, Arterie, AortaGen Consortium, Cardiogenics consortium, Locus (genetics), Biology, Polymorphism, Single Nucleotide, Article, Follow-Up Studie, 03 medical and health sciences, Internal medicine, medicine, Humans, cardiovascular diseases, METAANALYSIS, 030304 developmental biology, Genetic association, Science & Technology, HYPERTENSION, MORTALITY, Case-control study, CARDIOVASCULAR-DISEASE RISK, 06 Biological Sciences, GENE, MICE, Endocrinology, Blood pressure, CKDGen consortium, Genetic Loci, Case-Control Studies, KidneyGen consortium, CHARGE Consortium Heart Failure Working Group, LifeLines Cohort Study, Developmental Biology, Follow-Up Studies, Genome-Wide Association Study
Abstract: Les affiliations des 100 premiers auteurs sont renseignées dans la notice. Les affiliations des autres auteurs sont disponibles à la fin de la publication.; International audience; Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Published: 2016

13. Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

Author: Brænne, Ingrid, Zeng, Lingyao, Willenborg, Christina, Tragante, Vinicius, Kessler, Thorsten, Willer, Cristen J., Laakso, Markku, Wallentin, Lars, Franks, Paul W., Salomaa, Veikko, Dehghan, Abbas, Meitinger, Thomas, Samani, Nilesh J., Asselbergs, Folkert W., Erdmann, Jeanette, Schunkert, Heribert, Deloukas, Panos, Kanoni, Stavroula, Farrall, Martin, Assimes, Themistocles L., Thompson, John R., Ingelsson, Erik, Saleheen, Danish, Goldstein, Benjamin A., Stirrups, Kathleen, König, Inke R., Cazier, Jean-Baptiste, Johansson, Åsa, Hall, Alistair S., Lee, Jong-Young, Chambers, John C., Esko, Tõnu, Folkersen, Lasse, Goel, Anuj, Grundberg, Elin, Havulinna, Aki S., Weang K., Ho, Hopewell, Jemma C., Eriksson, Niclas, Kleber, Marcus E., Kristiansson, Kati, Lundmark, Per, Lyytikäinen, Leo-Pekka, Rafelt, Suzanne, Shun, Dmitry, Strawbridge, Rona J., Thorleifsson, Gudmar, Tikkanen, Emmi, Van Zuydam, Natalie, Voight, Benjamin F., Waite, Lindsay L., Zhang, Weihua, Zieg, Andreas, Absher, Devin, Altshuler, David, Balmforth, Anthony J., Barroso, Inês, Braund, Peter S., Burgdorf, Christof, Claudi-Boehm, Simone, Cox, David, Dimitriou, Maria, Ron, Do, Doney, Alex S. F., El Mokhtari, Nour Eddine, Eriksson, Per, Fischer, Krista, Fontanillas, Pierre, Franco-Cereceda, Anders, Gigante, Bruna, Groop, Leif, Gustafsson, Stefan, Hager, Jörg, Hallmans, Göran, Han, Bok-Ghee, Ehunt, Sarah, Kang, Hyun M., Illig, Thomas, Knowles, Joshua W., Kolovou, Genovefa, Kuusisto, Johanna, Langenberg, Claudia, Langford, Cordelia, Leander, Karin, Lokki, Marja-Liisa, Lundmark, Anders, Mccarthy, Mark I., Meisinger, Christa, Melander, Olle, Mihailov, Evelin, Maouche, Seraya, Morris, Andrew D., Müller-Nurasyid, Martina, Nikus, Kjell, Peden, John F., Rayner, N. William, Rasheed, Asif, Rosinger, Silke, Rubin, Diana, Rumpf, Moritz P., Schäfer, Arne, Sivananthan, Mohan, Song, Ci, Stewart, Alexandre F. R., Tan, Sian-Tsung, Thorgeirsson, Gudmundur, Van Der Schoot, C. Ellen, Wagner, Peter J., Wells, George A., Wild, Philipp S., Yang, Tsun-Po, Amouyel, Philippe, Arveiler, Dominique, Basart, Hanneke, Boehnke, Michael, Boerwinkle, Eric, Brambilla, Paolo, Cambien, Francois, Cupples, Adrienne L., De Faire, Ulf, Diemert, Patrick, Epstein, Stephen E., Evans, Alun, Ferrario, Marco M., Ferrières, Jean, Gauguier, Dominique, Alan S., Go, Goodall, Alison H., Gudnason, Villi, Hazen, Stanley L., Holm, Hilma, Iribarren, Carlos, Jang, Yangsoo, Kähönen, Mika, Kee, Frank, Kim, Hyo-Soo, Klopp, Norman, Koenig, Wolfgang, Kratzer, Wolfgang, Kuulasmaa, Kari, Laaksonen, Reijo, Lee, Ji-Young, Lind, Lars, Ouwehand, Willem H., Parish, Sarah, Park, Jeong E., Pedersen, Nancy L., Peters, Annette, Quertermous, Thomas, Rader, Daniel J., Schadt, Eric, Shah, Svati H., Sinisalo, Juha, Stark, Klaus, Stefansson, Kari, Trégouët, David-Alexandre, Virtamo, Jarmo, Wareham, Nicholas, Zimmermann, Martina E., Nieminen, Markku S., Hengsten, Christian, Sandhu, Manjinder S., Pastinen, Tomi, Syvänen, Ann-Christine, Hovingh, G. Kees, Dedoussis, George, Lehtimäki, Terho, Metspalu, Andres, Zalloua, Pierre A., Siegbahn, Agneta, Schreiber, Stefan, Ripatti, Samuli, Blankenberg, Stefan S., Perola, Markus, Clarke, Robert, Oboehm, Bernhard, O’Donnell, Christopher, Reilly, Muredach P., März, Winfried, Collins, Rory, Kathiresan, Sekar, Hamsten, Anders, Kooner, Jaspal S., Thorsteinsdottir, Unnur, Danesh, John, Palmer, Colin N. A., Roberts, Robert, Watkins, Hugh, Hall, Alistair, Hengstenberg, Christian, Mcpherson, Ruth, Ziegler, Andreas, Brænne, I, Zeng, L, Willenborg, C, Tragante, V, Kessler, T, Willer, C, Laakso, M, Wallentin, L, Franks, P, Salomaa, V, Dehghan, A, Meitinger, T, Samani, N, Asselbergs, F, Erdmann, J, Schunkert, H, Deloukas, P, Kanoni, S, Farrall, M, Assimes, T, Thompson, J, Ingelsson, E, Saleheen, D, Goldstein, B, Absher, D, König, I, Cazier, J, Johansson, Å, Hall, A, Lee, J, Chambers, J, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Kleber, M, Kristiansson, K, Lundmark, P, Lyytikäinen, L, Rafelt, S, Shun, D, Strawbridge, R, Thorleifsson, G, Tikkanen, E, Van Zuydam, N, Voight, B, Waite, L, Zhang, W, Zieg, A, Altshuler, D, Balmforth, A, Barroso, I, Braund, P, Burgdorf, C, Claudi-Boehm, S, Cox, D, Dimitriou, M, Do, R, Doney, A, El Mokhtari, N, Eriksson, P, Fischer, K, Fontanillas, P, Franco-Cereceda, A, Gigante, B, Groop, L, Gustafsson, S, Hager, J, Hallmans, G, Han, B, Ehunt, S, Kang, H, Illig, T, Knowles, J, Kolovou, G, Kuusisto, J, Langenberg, C, Langford, C, Leander, K, Lokki, M, Lundmark, A, Mccarthy, M, Meisinger, C, Melander, O, Mihailov, E, Maouche, S, Morris, A, Müller-Nurasyid, M, Nikus, K, Peden, J, Rayner, N, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schäfer, A, Sivananthan, M, Song, C, Stewart, A, Tan, S, Thorgeirsson, G, Van Der Schoot, C, Wagner, P, Wells, G, Wild, P, Yang, T, Amouyel, P, Arveiler, D, Basart, H, Boehnke, M, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, A, De Faire, U, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Ferrières, J, Gauguier, D, Go, A, Goodall, A, Gudnason, V, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kähönen, M, Kee, F, Kim, H, Klopp, N, Koenig, W, Kratzer, W, Kuulasmaa, K, Laaksonen, R, Lind, L, Ouwehand, W, Parish, S, Park, J, Pedersen, N, Peters, A, Quertermous, T, Rader, D, Schadt, E, Shah, S, Sinisalo, J, Stark, K, Stefansson, K, Trégouët, D, Virtamo, J, Wareham, N, Zimmermann, M, Nieminen, M, Hengsten, C, Sandhu, M, Pastinen, T, Syvänen, A, Hovingh, G, Dedoussis, G, Lehtimäki, T, Metspalu, A, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, Perola, M, Clarke, R, Oboehm, B, O’Donnell, C, Reilly, M, März, W, Collins, R, Kathiresan, S, Hamsten, A, Kooner, J, Thorsteinsdottir, U, Danesh, J, Palmer, C, Roberts, R, Watkins, H, Hengstenberg, C, Mcpherson, R, Ziegler, A, and Epidemiology
Subjects: Genetics and Molecular Biology (all), Cell biology, Cell signaling, BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, Cardiovascular Diseases, Case-Control Studies, Glatiramer Acetate, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genetic Predisposition to Disease, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Cardiology, Gene Expression, Signal transduction, Research and Analysis Methods, Vascular Medicine, Biochemistry, Database and Informatics Methods, Mathematical and Statistical Techniques, Cardiovascular Disease, Medicine and Health Sciences, Genetics, Genome-Wide Association Studies, Journal Article, Coronary Heart Disease, Statistical Methods, Polymorphism, Biology and life sciences, Signaling cascades, Computational Biology, Human Genetics, Genomics, Single Nucleotide, Genomic Databases, Genome Analysis, Biological Databases, TGF-beta signaling cascade, Genetic Loci, Physical Sciences, Case-Control Studie, Genomic Signal Processing, Mathematics, Statistics (Mathematics), Research Article, Meta-Analysis, Human
Abstract: Glatiramer acetate is used therapeutically in multiple sclerosis but also known for adverse effects including elevated coronary artery disease (CAD) risk. The mechanisms underlying the cardiovascular side effects of the medication are unclear. Here, we made use of the chromosomal variation in the genes that are known to be affected by glatiramer treatment. Focusing on genes and gene products reported by drug-gene interaction database to interact with glatiramer acetate we explored a large meta-analysis on CAD genome-wide association studies aiming firstly, to investigate whether variants in these genes also affect cardiovascular risk and secondly, to identify new CAD risk genes. We traced association signals in a 200-kb region around genomic positions of genes interacting with glatiramer in up to 60 801 CAD cases and 123 504 controls. We validated the identified association in additional 21 934 CAD cases and 76 087 controls. We identified three new CAD risk alleles within the TGFB1 region on chromosome 19 that independently affect CAD risk. The lead SNP rs12459996 was genome-wide significantly associated with CAD in the extended meta-analysis (odds ratio 1.09, p = 1.58x10(-12)). The other two SNPs at the locus were not in linkage disequilibrium with the lead SNP and by a conditional analysis showed p-values of 4.05 x 10(-10) and 2.21 x 10(-6). Thus, studying genes reported to interact with glatiramer acetate we identified genetic variants that concordantly with the drug increase the risk of CAD. Of these, TGFB1 displayed signal for association. Indeed, the gene has been associated with CAD previously in both in vivo and in vitro studies. Here we establish genome-wide significant association with CAD in large human samples.
Published: 2017

14. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author: Wain, Louise V, Verwoert, Germaine C, O'Reilly, Paul F, Shi, Gang, Johnson, Toby, Johnson, Andrew D, Bochud, Murielle, Rice, Kenneth M, Henneman, Peter, Smith, Albert V, Ehret, Georg B, Amin, Najaf, Larson, Martin G, Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile JW, Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'an, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U, Webster, Rebecca J, Zhang, Feng, Peden, John F, Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I, Trompet, Stella, Bragg-Gresham, Jennifer L, Alizadeh, Behrooz Z, Chambers, John C, Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M, Polašek, Ozren, Boban, Mladen, Nelson, Christopher P, Morrison, Alanna C, Pihur, Vasyl, Ganesh, Santhi K, Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco US, Rivadeneira, Fernando, Sijbrands, Eric JG, Uitterlinden, Andre G, Hwang, Shih-Jen, Vasan, Ramachandran S, Wang, Thomas J, Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L, Kroemer, Heyo K, Völker, Uwe, Völzke, Henry, Glazer, Nicole L, Taylor, Kent D, Harris, Tamara B, Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, Inês, Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M, Penninx, Brenda W, Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, d'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco, Fabiola M, Facheris, Maurizio, Collins, Francis S, Bergman, Richard N, Beilby, John P, Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S, Navarro, Pau, Wild, Sarah H, Corsi, Anna Maria, Singleton, Andrew, de Geus, Eco JC, Willemsen, Gonneke, Parker, Alex N, Rose, Lynda M, Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, LifeLines Cohort Study, van der Klauw, Melanie M, Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M, Emilsson, Valur, Plump, Andrew, Lindeman, Jan H, Hoen, Peter AC 't, König, Inke R, EchoGen consortium, Felix, Janine F, Clarke, Robert, Hopewell, Jemma C, Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L, Fornage, Myriam, AortaGen Consortium, Mitchell, Gary F, CHARGE Consortium Heart Failure Working Group, Smith, Nicholas L, KidneyGen consortium, Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, CKDGen consortium, Cardiogenics consortium, CardioGram, Samani, Nilesh J, Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J, Wichmann, H-Erich, Raitakari, Olli T, Palmas, Walter, Kooner, Jaspal S, Stolk, Ronald P, Jukema, J Wouter, Wright, Alan F, Boomsma, Dorret I, Bandinelli, Stefania, Gyllensten, Ulf B, Wilson, James F, Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D, Palmer, Lyle J, Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth JF, Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J, Oostra, Ben A, Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P, Beckmann, Jacques S, Witteman, Jacqueline CM, Erdmann, Jeanette, van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M, Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R, Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B, Psaty, Bruce M, Caulfield, Mark J, Rao, Dabeeru C, Tobin, Martin D, Elliott, Paul, van Duijn, Cornelia M, Zhao, Jing Hua [0000-0003-4930-3582], Luan, Jian'an [0000-0003-3137-6337], Barroso, Ines [0000-0001-5800-4520], Khaw, Kay-Tee [0000-0002-8802-2903], Soranzo, Nicole [0000-0003-1095-3852], Wareham, Nicholas [0000-0003-1422-2993], and Apollo - University of Cambridge Repository
Subjects: Genetic Loci, Case-Control Studies, Hypertension, Humans, Blood Pressure, cardiovascular diseases, Arteries, Polymorphism, Single Nucleotide, Linkage Disequilibrium, circulatory and respiratory physiology, Follow-Up Studies, Genome-Wide Association Study
Abstract: Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Published: 2011

15. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Author: Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, Van Der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan JL, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, De Borst, Martin H, De Grandi, Alessandro, De Mutsert, Renée, De Vries, Aiko PJ, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent WV, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, Loeffler, Markus, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Maranville, Joseph C, Mascalzoni, Deborah, McMullen, Barbara, Meisinger, Christa, Meitinger, Thomas, Miliku, Kozeta, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Mychaleckyj, Josyf C, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Noordam, Raymond, Connell, Jeffrey O', Olafsson, Isleifur, Palmer, Nicholette D, Peters, Annette, Podgornaia, Anna I, Ponte, Belen, Poulain, Tanja, Pramstaller, Peter P, Rabelink, Ton J, Raffield, Laura M, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rivadeneira, Fernando, Runz, Heiko, Ryan, Kathleen A, Sabanayagam, Charumathi, Saum, Kai-Uwe, Schöttker, Ben, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Strauch, Konstantin, Stumvoll, Michael, Sun, Benjamin B, Szymczak, Silke, Tai, E-Shyong, Tan, Nicholas YQ, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris HL, Thomsen, Hauke, Thorsteinsdottir, Unnur, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, Van Der Harst, Pim, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Waldenberger, Melanie, Wang, Chaolong, Wilson, Otis D, Wong, Charlene, Wong, Tien-Yin, Yang, Qiong, Yasuda, Masayuki, Akilesh, Shreeram, Bochud, Murielle, Böger, Carsten A, Devuyst, Olivier, Edwards, Todd L, Ho, Kevin, Morris, Andrew P, Parsa, Afshin, Pendergrass, Sarah A, Psaty, Bruce M, Rotter, Jerome I, Stefansson, Kari, Wilson, James G, Susztak, Katalin, Snieder, Harold, Heid, Iris M, Scholz, Markus, Butterworth, Adam S, Hung, Adriana M, Pattaro, Cristian, and Köttgen, Anna
Subjects: Chromosome Mapping, 3. Good health, Drosophila melanogaster, Gene Expression Regulation, Meta-Analysis as Topic, Genetic Loci, Risk Factors, Creatinine, Diabetes Mellitus, Albuminuria, Animals, Humans, Genetic Predisposition to Disease, Phenomics, Genome-Wide Association Study
Abstract: Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.

16. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Author: Ntalla, Ioanna, Weng, Lu-Chen, Cartwright, James H, Hall, Amelia Weber, Sveinbjornsson, Gardar, Tucker, Nathan R, Choi, Seung Hoan, Chaffin, Mark D, Roselli, Carolina, Barnes, Michael R, Mifsud, Borbala, Warren, Helen R, Hayward, Caroline, Marten, Jonathan, Cranley, James J, Concas, Maria Pina, Gasparini, Paolo, Boutin, Thibaud, Kolcic, Ivana, Polasek, Ozren, Rudan, Igor, Araujo, Nathalia M, Lima-Costa, Maria Fernanda, Ribeiro, Antonio Luiz P, Souza, Renan P, Tarazona-Santos, Eduardo, Giedraitis, Vilmantas, Ingelsson, Erik, Mahajan, Anubha, Morris, Andrew P, Del Greco M, Fabiola, Foco, Luisa, Gögele, Martin, Hicks, Andrew A, Cook, James P, Lind, Lars, Lindgren, Cecilia M, Sundström, Johan, Nelson, Christopher P, Riaz, Muhammad B, Samani, Nilesh J, Sinagra, Gianfranco, Ulivi, Sheila, Kähönen, Mika, Mishra, Pashupati P, Mononen, Nina, Nikus, Kjell, Caulfield, Mark J, Dominiczak, Anna, Padmanabhan, Sandosh, Montasser, May E, O'Connell, Jeff R, Ryan, Kathleen, Shuldiner, Alan R, Aeschbacher, Stefanie, Conen, David, Risch, Lorenz, Thériault, Sébastien, Hutri-Kähönen, Nina, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Raitakari, Olli T, Barnes, Catriona LK, Campbell, Harry, Joshi, Peter K, Wilson, James F, Isaacs, Aaron, Kors, Jan A, Van Duijn, Cornelia M, Huang, Paul L, Gudnason, Vilmundur, Harris, Tamara B, Launer, Lenore J, Smith, Albert V, Bottinger, Erwin P, Loos, Ruth JF, Nadkarni, Girish N, Preuss, Michael H, Correa, Adolfo, Mei, Hao, Wilson, James, Meitinger, Thomas, Müller-Nurasyid, Martina, Peters, Annette, Waldenberger, Melanie, Mangino, Massimo, Spector, Timothy D, Rienstra, Michiel, Van De Vegte, Yordi J, Van Der Harst, Pim, Verweij, Niek, Kääb, Stefan, Schramm, Katharina, Sinner, Moritz F, Strauch, Konstantin, Cutler, Michael J, Fatkin, Diane, London, Barry, Olesen, Morten, Roden, Dan M, Benjamin Shoemaker, M, Gustav Smith, J, Biggs, Mary L, Bis, Joshua C, Brody, Jennifer A, Psaty, Bruce M, Rice, Kenneth, Sotoodehnia, Nona, De Grandi, Alessandro, Fuchsberger, Christian, Pattaro, Cristian, Pramstaller, Peter P, Ford, Ian, Wouter Jukema, J, Macfarlane, Peter W, Trompet, Stella, Dörr, Marcus, Felix, Stephan B, Völker, Uwe, Weiss, Stefan, Havulinna, Aki S, Jula, Antti, Sääksjärvi, Katri, Salomaa, Veikko, Guo, Xiuqing, Heckbert, Susan R, Lin, Henry J, Rotter, Jerome I, Taylor, Kent D, Yao, Jie, De Mutsert, Renée, Maan, Arie C, Mook-Kanamori, Dennis O, Noordam, Raymond, Cucca, Francesco, Ding, Jun, Lakatta, Edward G, Qian, Yong, Tarasov, Kirill V, Levy, Daniel, Lin, Honghuang, Newton-Cheh, Christopher H, Lunetta, Kathryn L, Murray, Alison D, Porteous, David J, Smith, Blair H, Stricker, Bruno H, Uitterlinden, André, Van Den Berg, Marten E, Haessler, Jeffrey, Jackson, Rebecca D, Kooperberg, Charles, Peters, Ulrike, Reiner, Alexander P, Whitsel, Eric A, Alonso, Alvaro, Arking, Dan E, Boerwinkle, Eric, Ehret, Georg B, Soliman, Elsayed Z, Avery, Christy L, Gogarten, Stephanie M, Kerr, Kathleen F, Laurie, Cathy C, Seyerle, Amanda A, Stilp, Adrienne, Assa, Solmaz, Abdullah Said, M, Yldau Van Der Ende, M, Lambiase, Pier D, Orini, Michele, Ramirez, Julia, Van Duijvenboden, Stefan, Arnar, David O, Gudbjartsson, Daniel F, Holm, Hilma, Sulem, Patrick, Thorleifsson, Gudmar, Thorolfsdottir, Rosa B, Thorsteinsdottir, Unnur, Benjamin, Emelia J, Tinker, Andrew, Stefansson, Kari, Ellinor, Patrick T, Jamshidi, Yalda, Lubitz, Steven A, and Munroe, Patricia B
Subjects: Male, Multifactorial Inheritance, Endophenotypes, Quantitative Trait Loci, Gene Expression, Genetic Variation, Arrhythmias, Cardiac, 3. Good health, Electrocardiography, Cardiovascular Diseases, Genetic Loci, Humans, Female, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract: The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.

17. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

Author: Tin, Adrienne, Marten, Jonathan, Halperin Kuhns, Victoria L, Li, Yong, Wuttke, Matthias, Kirsten, Holger, Sieber, Karsten B, Qiu, Chengxiang, Gorski, Mathias, Yu, Zhi, Giri, Ayush, Sveinbjornsson, Gardar, Li, Man, Chu, Audrey Y, Hoppmann, Anselm, O'Connor, Luke J, Prins, Bram, Nutile, Teresa, Noce, Damia, Akiyama, Masato, Cocca, Massimiliano, Ghasemi, Sahar, Van Der Most, Peter J, Horn, Katrin, Xu, Yizhe, Fuchsberger, Christian, Sedaghat, Sanaz, Afaq, Saima, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan JL, Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L, Biino, Ginevra, Boerwinkle, Eric, Bottinger, Erwin P, Boutin, Thibaud S, Brumat, Marco, Burkhardt, Ralph, Campana, Eric, Campbell, Archie, Campbell, Harry, Carroll, Robert J, Catamo, Eulalia, Chambers, John C, Ciullo, Marina, Concas, Maria Pina, Coresh, Josef, Corre, Tanguy, Cusi, Daniele, Felicita, Sala Cinzia, De Borst, Martin H, De Grandi, Alessandro, De Mutsert, Renée, De Vries, Aiko PJ, Delgado, Graciela, Demirkan, Ayşe, Devuyst, Olivier, Dittrich, Katalin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Evans, Michele K, Gansevoort, Ron T, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Gögele, Martin, Gordon, Scott D, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Study, German Chronic Kidney Disease, Haller, Toomas, Hamet, Pavel, Harris, Tamara B, Hayward, Caroline, Hicks, Andrew A, Hofer, Edith, Holm, Hilma, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Lewis, Raychel M, Ingelsson, Erik, Jakobsdottir, Johanna, Jonsdottir, Ingileif, Jonsson, Helgi, Joshi, Peter K, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Kerr, Shona M, Kiess, Wieland, Kleber, Marcus E, Koenig, Wolfgang, Kooner, Jaspal S, Körner, Antje, Kovacs, Peter, Krämer, Bernhard K, Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, La Bianca, Martina, Lange, Leslie A, Lehne, Benjamin, Lehtimäki, Terho, Lifelines Cohort Study, Liu, Jun, Loeffler, Markus, Loos, Ruth JF, Lyytikäinen, Leo-Pekka, Magi, Reedik, Mahajan, Anubha, Martin, Nicholas G, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, V. A. Million Veteran Program, O'Donnell, Christopher J, Wilson, Otis D, Gaziano, J Michael, Mishra, Pashupati P, Mohlke, Karen L, Mononen, Nina, Montgomery, Grant W, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Nadkarni, Girish N, Nalls, Mike A, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, Noordam, Raymond, O'Connell, Jeffrey R, Olafsson, Isleifur, Padmanabhan, Sandosh, Penninx, Brenda WJH, Perls, Thomas, Peters, Annette, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Polasek, Ozren, Ponte, Belen, Porteous, David J, Poulain, Tanja, Preuss, Michael H, Rabelink, Ton J, Raffield, Laura M, Raitakari, Olli T, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rizzi, Federica, Robino, Antonietta, Rudan, Igor, Krajcoviechova, Alena, Cifkova, Renata, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A, Saba, Yasaman, Salvi, Erika, Schmidt, Helena, Schmidt, Reinhold, Shaffer, Christian M, Smith, Albert V, Smith, Blair H, Spracklen, Cassandra N, Strauch, Konstantin, Stumvoll, Michael, Sulem, Patrick, Tajuddin, Salman M, Teren, Andrej, Thiery, Joachim, Thio, Chris HL, Thorsteinsdottir, Unnur, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, Vaccargiu, Simona, Van Der Harst, Pim, Van Duijn, Cornelia M, Verweij, Niek, Völker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Whitfield, John B, Wild, Sarah H, Wilson, James F, Yang, Qiong, Zhang, Weihua, Zonderman, Alan B, Bochud, Murielle, Wilson, James G, Pendergrass, Sarah A, Ho, Kevin, Parsa, Afshin, Pramstaller, Peter P, Psaty, Bruce M, Böger, Carsten A, Snieder, Harold, Butterworth, Adam S, Okada, Yukinori, Edwards, Todd L, Stefansson, Kari, Susztak, Katalin, Scholz, Markus, Heid, Iris M, Hung, Adriana M, Teumer, Alexander, Pattaro, Cristian, Woodward, Owen M, Vitart, Veronique, and Köttgen, Anna
Subjects: Genetic Markers, Gout, Kidney, Polymorphism, Single Nucleotide, 3. Good health, Neoplasm Proteins, Uric Acid, Cohort Studies, Hepatocyte Nuclear Factor 4, Liver, Metabolic Diseases, Cardiovascular Diseases, Genetic Loci, Organ Specificity, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 1-alpha, Genome-Wide Association Study, Signal Transduction
Abstract: Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.

18. Mapping the human genetic architecture of COVID-19

Author: Niemi, MEK, Karjalainen, J, Liao, RG, Neale, BM, Daly, M, Ganna, A, Pathak, GA, Andrews, SJ, Kanai, M, Veerapen, K, Fernandez-Cadenas, I, Schulte, EC, Striano, P, Marttila, M, Minica, C, Marouli, E, Karim, MA, Wendt, FR, Savage, J, Sloofman, L, Butler-Laporte, G, Kim, H-N, Kanoni, S, Okada, Y, Byun, J, Han, Y, Uddin, MJ, Smith, GD, Willer, CJ, Buxbaum, JD, Mehtonen, J, Finucane, H, Cordioli, M, Martin, AR, Zhou, W, Pasaniuc, B, Julienne, H, Aschard, H, Shi, H, Yengo, L, Polimanti, R, Ghoussaini, M, Schwartzentruber, J, Dunham, I, Chwialkowska, K, Francescatto, M, Trankiem, A, Balaconis, MK, Davis, L, Lee, S, Priest, J, Renieri, A, Sankaran, VG, van Heel, D, Deelen, P, Richards, JB, Nakanishi, T, Biesecker, L, Kerchberger, VE, Kenneth, J, Mari, F, Bernasconi, A, Ceri, S, Canakoglu, A, Wolford, B, Faucon, A, Dutta, AK, Schurmann, C, Harry, E, Birney, E, Nguyen, H, Nasir, J, Kaunisto, M, Solomonson, M, Dueker, N, Vadgama, N, Limou, S, Rahmouni, S, Mbarek, H, Darwish, D, Uddin, MM, Albertos, R, Perez-Tur, J, Li, R, Folkersen, L, Moltke, I, Koelling, N, Teumer, A, Kousathanas, A, Utrilla, A, Verdugo, RA, Zarate, R, Medina-Gomez, C, Gomez-Cabrero, D, Carnero-Montoro, E, Cadilla, CL, Moreno-Estrada, A, Garmendia, A, Moya, L, Sedaghati-Khayat, B, Boua, PR, Fave, M-J, Francioli, L, Lemacon, A, Migeotte, I, Patel, S, Varnai, R, Szentpeteri, JL, Sipeky, C, Colombo, F, von Hohenstaufen, K, Lio, P, Vallerga, C, Wang, Q, Tanigawa, Y, Im, H, Han, C, Song, H, Lim, J, Lee, Y, Kim, S, Im, S, Atanasovska, B, Ahmad, HF, Boer, C, Jansen, P, Franke, L, Kaja, E, Pasko, D, Kennis-Szilagyi, I, Kornilov, SA, Prijatelj, V, Prokic, I, Sivanadhan, I, Perumal, S, Esmaeeli, S, Pearson, NM, Auton, A, Shelton, JF, Shastri, AJ, Filshtein-Sonmez, T, Coker, D, Symons, A, Esparza-Gordillo, J, Aslibekyan, S, O'Connell, J, Ye, C, Weldon, CH, Perera, M, O'Leary, K, Tuck, M, O'Brien, T, Meltzer, D, O'Donnell, P, Nutescu, E, Yang, G, Alarcon, C, Herrmann, S, Mazurek, S, Banagan, J, Hamidi, Z, Barbour, A, Raffat, N, Moreno, D, Friedman, P, Ferwerda, B, van de Beek, D, Brouwer, MC, Vlaar, APJ, Wiersinga, WJ, Posthuma, D, Tissink, E, Zwinderman, AHK, Uffelmann, E, van Agtmael, M, Algera, AG, van Baarle, F, Bax, D, Beudel, M, Bogaard, HJ, Bomers, M, Bonta, PI, Bos, L, Botta, M, de Brabander, J, de Bree, G, de Bruin, S, Bugiani, M, Bulle, E, Chouchane, O, Cloherty, A, Dongelmans, D, Elbers, P, Fleuren, L, Geerlings, S, Geerts, B, Geijtenbeek, T, Girbes, A, Goorhuis, B, Grobusch, MP, Hafkamp, F, Hagens, L, Hamann, J, Harris, V, Hemke, R, Hermans, SM, Heunks, L, Hollmann, M, Horn, J, Hovius, JW, de Jong, MD, Koning, R, van Mourik, N, Nellen, J, Nossent, EJ, Paulus, F, Peters, E, van der Poll, T, Preckel, B, Prins, JM, Raasveld, J, Reijnders, T, Schinkel, M, Schultz, MJ, Schuurman, A, Sigaloff, K, Smit, M, Stijnis, CS, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A, van der Valk, M, Veelo, D, de Vries, H, van Vugt, M, Wouters, D, Minnaar, RP, Kromhout, A, van Uffelen, KWJ, Wolterman, RA, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Bouysran, Y, Busson, A, Peyrassol, X, Wilkin, F, Pichon, B, Smits, G, Vandernoot, I, Goffard, J-C, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Jadot, L, Azarzar, S, Dellot, P, Gofflot, S, Claassen, S, Bertrand, A, Parzibut, G, Clarinval, M, Moermans, C, Malaise, O, El Kandoussi, K, Thonon, R, Huynen, P, Mesdagh, A, Melo, S, Jacques, N, Di Valentin, E, Giroule, F, Collignon, A, Radermecker, C, Lebrun, M, Peree, H, Latour, S, Barada, O, Sanchez, J, Josse, C, Boujemla, B, Meunier, M, Mariavelle, E, Anania, S, Gazon, H, Juszczak, D, Fadeur, M, Camby, S, Meuris, C, Thys, M, Jacques, J, Henket, M, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Von Frenckell, C, Mni, M, Wery, M, Staderoli, A, Belhaj, Y, Lambermont, B, Morrison, DR, Mooser, V, Forgetta, V, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chasse, M, Kaufmann, DE, Lathrop, GM, Adra, D, Davis, LK, Cox, NJ, Below, JE, Sealock, JM, Faucon, AB, Shuey, MM, Polikowsky, HG, Petty, LE, Shaw, DM, Chen, H-H, Zhu, W, Ludwig, KU, Schroeder, J, Maj, C, Rolker, S, Noethen, MM, Fazaal, J, Keitel, V, Jensen, B-EO, Feldt, T, Kurth, I, Marx, N, Dreher, M, Pink, I, Cornberg, M, Illig, T, Lehmann, C, Schommers, P, Augustin, M, Rybniker, J, Knopp, L, Eggermann, T, Volland, S, Altmueller, J, Berger, MM, Brenner, T, Hinney, A, Witzke, O, Bals, R, Herr, C, Ludwig, N, Walter, J, Fuchsberger, C, Pattaro, C, De Grandi, A, Pramstaller, P, Emmert, D, Melotti, R, Foco, L, Mascalzoni, D, Gogele, M, Domingues, F, Hicks, A, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Goldstein, DB, Kiryluk, K, Sengupta, S, Chung, W, Reilly, MP, Khan, A, Wang, C, Povysil, G, Bhardwaj, N, Gharavi, AG, Ionita-Laza, I, Shang, N, O'Byrne, SM, Nandakumar, R, Menon, A, So, YS, Hod, E, Pendrick, D, Park, S-K, Kim, H-L, Kang, CK, Lee, H-J, Song, K-H, Yoon, KJ, Paik, N-J, Seok, W, Yoon, H, Joo, E-J, Chang, Y, Ryu, S, Park, WB, Park, JS, Park, KU, Ham, SY, Jung, J, Kim, ES, Kim, HB, Ellinghaus, D, Degenhardt, F, Caceres, M, Juzenas, S, Lenz, TL, Albillos, A, Julia, A, Heidecker, B, Garcia, F, Kurth, F, Tran, F, Hanses, F, Zoller, H, Holter, JC, Fernandez, J, Sander, LE, Rosenstiel, P, Koehler, P, de Cid, R, Asselta, R, Schreiber, S, Hehr, U, Prati, D, Baselli, G, Valenti, L, Bujanda, L, Banales, JM, Duga, S, D'Amato, M, Romero-Gomez, M, Buti, M, Invernizzi, P, Franke, A, Hov, JR, Karlsen, TH, Folseraas, T, Maya-Miles, D, Teles, A, Azuure, C, Wacker, EM, Uellendahl-Werth, F, Elabd, H, Arora, J, Lerga-Jaso, J, Wienbrandt, L, Ruehlemann, MC, Wendorff, M, Vadla, MS, Lenning, OB, Oezer, O, Myhre, R, Raychaudhuri, S, Tanck, A, Gassner, C, Hemmrich-Stanisak, G, Kaessens, J, Basso, MEF, Schulzky, M, Wittig, M, Braun, N, Wesse, T, Albrecht, W, Yi, X, Ortiz, AB, Garrido Chercoles, A, Ruiz, A, Mantovani, A, Holten, AR, Mayer, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Barreira, A, Lleo, A, Kildal, AB, Glueck, A, Carreras Nolla, A, Latiano, A, Dyrhol-Riise, AM, Muscatello, A, Voza, A, Rando-Segura, A, Solier, A, Karina, B, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Bellinghausen, C, Ferrando, C, Quereda, C, Skurk, C, Thibeault, C, Spinner, CD, Lange, C, Hu, C, Cappadona, C, Bianco, C, Sancho, C, Hoff, DAL, Galimberti, D, Jimenez, D, Pestana, D, Toapanta, D, Azzolini, E, Scarpini, E, Helbig, ET, Urrechaga, E, Paraboschi, EM, Pontali, E, Reverter, E, Navas, E, Arana, E, Garcia Sanchez, F, Ceriotti, F, Malvestiti, F, Mesonero, F, Pezzoli, G, Lamorte, G, Neb, H, My, I, Hernandez, I, de Rojas, I, Galvan-Femenia, I, Heyckendorf, J, Badia, JR, Schneider, J, Goikoetxea, J, Kraft, J, Mueller, KE, Gaede, KI, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Izquierdo-Sanchez, L, Sumoy, L, Lippert, LJ, Terranova, L, Garbarino, L, Tellez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Gutierrez-Stampa, MA, Vehreschild, MJGT, Marquie, M, Castoldi, M, Cecconi, M, Boada, M, Seilmaier, MJ, Mazzocco, M, Rodriguez-Gandia, M, Imaz Ayo, N, Blay, N, Martinez, N, Cornely, OA, Palmieri, O, Tentorio, P, Rodrigues, PM, Espana, PP, Hoffmann, P, Bacher, P, Suwalski, P, de Pablo, R, Nieto, R, Badalamenti, S, Ciesek, S, Bombace, S, Wilfling, S, Brunak, S, Heilmann-Heimbach, S, Ripke, S, Bahmer, T, Landmesser, U, Protzer, U, Rimoldi, V, Skogen, V, Andrade, V, Moreno, V, Poller, W, Farre, X, Wang, X, Khodamoradi, Y, Karadeniz, Z, de Salazar, A, Palom, A, Garcia-Fernandez, A-E, Blanco-Grau, A, Zanella, A, Bandera, A, Nebel, A, Biondi, A, Caba Llero-Garralda, A, Gori, A, Lind, A, Fracanzani, AL, Peschuck, A, Pesenti, A, De la Horra, C, Milani, C, Paccapelo, C, Angelini, C, Cea, C, Muniz-Diaz, E, Sandoval, E, Calderon, EJ, Solligard, E, Aziz, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Medrano, FJ, Rodriguez-Frias, F, Mueller, F, Grasselli, G, Costantino, G, Cardamone, G, Foti, G, Matullo, G, Kurihara, H, Afset, JE, Damas, JK, Ampuero, J, Martin, J, Erdmann, J, Bergan, J, Goerg, S, Ferrusquia-Acosta, J, Hernandez Quero, J, Delgado, J, Guerrero, JM, Risnes, K, Bettini, LR, Moreira, L, Gustad, LT, Santoro, L, Scudeller, L, Riveiro-Barciela, M, Schaefer, M, Carrabba, M, Valsecchi, MG, Hernandez-Tejero, M, Acosta-Herrera, M, D'Angio, M, Baldini, M, Cazzaniga, M, Ciccarelli, M, Bocciolone, M, Miozzo, M, Chueca, N, Montano, N, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Castro, P, Ferrer, R, Gualtierotti, R, Gallego-Duran, R, Morilla, R, Haider, S, Marsal, S, Aneli, S, Pelusi, S, Bosari, S, Aliberti, S, Dudman, S, Zheng, T, Pumarola, T, Gonzalez Cejudo, T, Monzani, V, Friaza, V, Peter, W, Dopazo, X, May, S, Grimsrud, MM, Gudbjartsson, DF, Stefansson, K, Sulem, P, Sveinbjornsson, G, Melsted, P, Norddahl, G, Moore, KHS, Thorsteinsdottir, U, Holm, H, Alarcon-Riquelme, ME, Bernardo, D, Martinez-Bueno, M, Rojo Rello, S, Magi, R, Milani, L, Metspalu, A, Laisk, T, Lall, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Palotie, A, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Bochud, PY, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Desgranges, F, Filippidis, P, Guery, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, Iou-Olivgeris, MP, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hugli, O, Meuwly, JY, Pantet, O, Bochud, M, D'Acremont, V, Younes, SE, Albrich, WC, Cerny, A, O'Mahony, L, von Mering, C, Frischknecht, M, Kleger, G-R, Filipovic, M, Kahlert, CR, Wozniak, H, Negro, TR, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, Carreras, A, Mercader, JM, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castano-Vinyals, G, Dobano, C, Gori, M, Mondelli, MU, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, MA, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, GP, Spagnesi, M, Canaccini, A, Ognibene, A, Monforte, AD, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, PG, Panese, S, Scaggiante, R, Della Monica, M, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Di Biagio, A, Masucci, L, Valente, S, Mandala, M, Zucchi, P, Giannattasio, F, Coviello, DA, Mussini, C, Bosio, G, Tavecchia, L, Crotti, L, Rizzi, M, La Rovere, MT, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Di Pietro, M, Sabrina, R, Luchi, S, Barbieri, C, Acquilini, D, Andreucci, E, Paciosi, F, Segala, FV, Tiseo, G, Falcone, M, Lista, M, Poscente, M, De Vivo, O, Petrocelli, P, Guarnaccia, A, Baroni, S, Perticaroli, V, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Bergomi, M, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, MA, Lo Rizzo, C, Pinto, AM, Beligni, G, Tommasi, A, Di Sarno, L, Palmieri, M, Carriero, ML, Alaverdian, D, Iuso, N, Inchingolo, G, Busani, S, Bruno, R, Vecchia, M, Belli, MA, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, MD, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Zanelli, G, Bergantini, L, D'Alessandro, M, Cameli, P, Bennet, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazi, A, Lorubbio, M, Merlini, E, Miraglia, FG, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Andretta, F, Gatti, F, Parisi, SG, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, GM, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Botta, G, Di Domenico, P, Rancan, I, Bianchi, F, Colombo, R, van Heel, DA, Hunt, KA, Trembath, RC, Huang, QQ, Martin, HC, Mason, D, Trivedi, B, Wright, J, Finer, S, Griffiths, CJ, Akhtar, S, Anwar, M, Arciero, E, Ashraf, S, Breen, G, Chung, R, Curtis, CJ, Chowdhury, M, Colligan, G, Deloukas, P, Durham, C, Griffiths, C, Hurles, M, Hussain, S, Islam, K, Lavery, C, Lee, SH, Lerner, R, MacArthur, D, MacLaughlin, B, Martin, H, Miah, S, Newman, B, Safa, N, Tahmasebi, F, Smith, AV, Boughton, AP, Li, KW, LeFaive, J, Annis, A, Jannes, CE, Krieger, JE, Pereira, AC, Velho, M, Marques, E, Lima, IR, Tada, MT, Valino, K, McCarthy, M, Rosenberger, C, Lee, JE, Chang, D, Hammer, C, Hunkapiller, J, Mahajan, A, Pendergrass, S, Sucheston-Campbell, L, Yaspan, B, Lee, HS, Shin, E, Jang, HY, Kym, S, Kim, Y-S, Jeong, H, Kwon, KT, Kim, S-W, Kim, JY, Jang, YR, Kim, HA, Lee, JY, Choe, K-W, Kang, YM, Jee, SH, Jung, KJ, Parikh, V, Ashley, E, Wheeler, M, Rivas, M, Bustamante, C, Pinksy, B, Febbo, P, Farh, K, Schroth, GP, deSouza, F, Dalton, K, Christle, J, Deboever, C, Szalma, S, Rubinacci, S, Delaneau, O, Gorzynski, J, de Jong, H, Sutton, S, Youlton, N, Joshi, R, Jimenez-Morales, D, Hughes, C, Amar, D, Ioannidis, A, Hershman, S, Kirillova, A, Seo, K, Huang, Y, Shoura, M, Hammond, N, Watson, N, Raja, A, Huang, C, Sahoo, M, Wang, H, Zhen, J, Rakitko, A, Ilinsky, V, Yermakovich, D, Popov, I, Chernitsov, A, Kovalenko, E, Krasnenko, A, Plotnikov, N, Stetsenko, I, Kim, A, Cirulli, ET, Barrett, KMS, Bolze, A, White, S, Washington, NL, Lu, JT, Riffle, S, Tanudjaja, F, III, RJM, Leonetti, N, Neveux, I, Dabe, S, Grzymski, JJ, Minano, JIE, Aguirre, LA, Lopez-Collazo, E, Pazos, MDLM, Cerrato, L, Lozano-Rodriguez, R, Avendano-Ortiz, J, Terron Arcos, V, Marina Montalban-Hernandez, K, Valentin Quiroga, J, Pascual-Iglesias, A, Maroun-Eid, C, Martin-Quiros, A, Namkoong, H, Imoto, S, Katayama, K, Fukunaga, K, Kitagawa, Y, Sato, T, Hasegawa, N, Kumanogoh, A, Kimura, A, Ai, M, Tokunaga, K, Kanai, T, Miyano, S, Ogawa, S, Edahiro, R, Sonehara, K, Shirai, Y, Ishii, M, Kabata, H, Masaki, K, Kamata, H, Ikemura, S, Chubachi, S, Okamori, S, Terai, H, Tanaka, H, Morita, A, Lee, H, Asakura, T, Sasaki, J, Morisaki, H, Uwamino, Y, Nanki, K, Mikami, Y, Tomono, K, Kato, K, Matsuda, F, Takahashi, M, Hizawa, N, Takeda, Y, Hirata, H, Shiroyama, T, Miyawaki, S, Suzuki, K, Maeda, Y, Nii, T, Noda, Y, Niitsu, T, Adachi, Y, Enomoto, T, Amiya, S, Hara, R, Takahashi, K, Anzai, T, Hasegawa, T, Ito, S, Koike, R, Endo, A, Uchimura, Y, Miyazaki, Y, Honda, T, Tateishi, T, Tohda, S, Ichimura, N, Sonobe, K, Sassa, C, Nakajima, J, Nannya, Y, Omae, Y, Harada, N, Hiki, M, Takagi, H, Nakamura, A, Tagaya, E, Kawana, M, Arimura, K, Ishiguro, T, Takayanagi, N, Isono, T, Takaku, Y, Takano, K, Anan, R, Nakajima, Y, Nakano, Y, Nishio, K, Ueda, S, Hayashi, R, Tateno, H, Hase, I, Yoshida, S, Suzuki, S, Mitamura, K, Saito, F, Ueda, T, Azuma, M, Nagasaki, T, Yasui, Y, Hasegawa, Y, Mutoh, Y, Yoshiyama, T, Shoko, T, Kojima, M, Adachi, T, Ishikawa, M, Watanabe, K, Manabe, T, Ito, F, Fukui, T, Funatsu, Y, Koh, H, Hirai, Y, Kawashima, H, Narita, A, Niwa, K, Sekikawa, Y, Yoshiya, K, Yoshihara, T, Suzuki, Y, Nakayama, S, Masuzawa, K, Nishi, K, Nishitsuji, M, Tani, M, Inoue, T, Hirano, T, Kobayashi, K, Miyazawa, N, Kimura, Y, Sado, R, Ogura, T, Kitamura, H, Murohashi, K, Nakachi, I, Baba, R, Arai, D, Fuke, S, Saito, H, Kuwahara, N, Fujiwara, A, Okada, T, Baba, T, Noda, J, Mashimo, S, Yagi, K, Shiomi, T, Hashiguchi, M, Odani, T, Mochimaru, T, Oyamada, Y, Mori, N, Izumi, N, Nagata, K, Taki, R, Murakami, K, Yamada, M, Sugiura, H, Hayashi, K, Shimizu, T, Gon, Y, Fujitani, S, Tsuchida, T, Yoshida, T, Kagaya, T, Kita, T, Sakagami, S, Kimizuka, Y, Kawana, A, Nakamura, Y, Ishikura, H, Takata, T, Kikuchi, T, Taniyama, D, Nakamura, M, Kodama, N, Kaneyama, Y, Maeda, S, Nagasaki, Y, Okamoto, M, Ishihara, S, Ito, A, Chihara, Y, Takeuchi, M, Onoi, K, Hashimoto, N, Wakahara, K, Ando, A, Masuda, M, Wakabayashi, A, Watanabe, H, Sageshima, H, Nakada, T-A, Abe, R, Shimada, T, Kawamura, K, Ichikado, K, Nishiyama, K, Yamasaki, M, Hashimoto, S, Kusaka, Y, Ohba, T, Isogai, S, Takada, M, Kanda, H, Komase, Y, Sano, F, Asano, K, Oguma, T, Harada, M, Takahashi, T, Shibusawa, T, Abe, S, Kono, Y, Togashi, Y, Izumo, T, Inomata, M, Awano, N, Ogata, T, Kanehiro, A, Ozaki, S, Fuchimoto, Y, Ogura, S, Yoshida, K, Beppu, S, Fukuyama, S, Eriguchi, Y, Yonekawa, A, Inoue, Y, Yamagata, K, Chiba, S, Narumoto, O, Nagai, H, Ooshima, N, Motegi, M, Sagara, H, Tanaka, A, Ohta, S, Shibata, Y, Tanino, Y, Sato, Y, Yamada, Y, Hashino, T, Shinoki, M, Iwagoe, H, Imamura, T, Umeda, A, Shimada, H, Endo, M, Hayashi, S, Nakano, S, Yatomi, M, Maeno, T, Ishii, T, Utsugi, M, Ono, A, Kanaoka, K, Ihara, S, Komuta, K, Boezen, M, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, JM, van Blokland, I, Lanting, P, Ori, APS, Obeidat, M, Cordero, AIH, Sin, DD, Bosse, Y, Joubert, P, Hao, K, Nickle, D, Timens, W, van den Berge, M, Feng, Y-CA, Mercader, J, Weiss, ST, Karlson, EW, Smoller, JW, Murphy, SN, Meigs, JB, Woolley, AE, Green, RC, Perez, EF, Zollner, S, Wang, J, Beck, A, Sloofman, LG, Ascolillo, S, Sebra, RP, Collins, BL, Levy, T, Sealfon, SC, Jordan, DM, Thompson, RC, Gettler, K, Chaudhary, K, Belbin, GM, Preuss, M, Hoggart, C, Choi, S, Underwood, SJ, Salib, I, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, LL, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Zyndorf, M, Charney, AW, Beckmann, ND, Schadt, EE, Abul-Husn, NS, Cho, JH, Itan, Y, Kenny, EE, Loos, RJF, Nadkarni, GN, Do, R, O'Reilly, P, Huckins, LM, Ferreira, MAR, Abecasis, GR, Leader, JB, Cantor, MN, Justice, AE, Carey, DJ, Chittoor, G, Josyula, NS, Kosmicki, JA, Horowitz, JE, Baras, A, Gass, MC, Yadav, A, Mirshahi, T, Hottenga, JJ, Bartels, M, de Geus, EJC, Nivard, MG, Verma, A, Ritchie, MD, Rader, D, Li, B, Verma, SS, Lucas, A, Bradford, Y, Zara, F, Salpietro, V, Scala, M, Iacomino, M, Scudieri, P, Bocciardi, R, Minetti, C, Vari, MS, Rahier, J-F, Giorgio, E, Carli, D, Louis, E, Bulik, CM, Landen, M, Brusco, A, Ferrero, GB, Madia, F, Fundin, B, Ismail, SI, Saad, C, Al-Sarraj, Y, Badji, RM, Al-Muftah, W, Al Thani, A, Afifi, N, Klovins, J, Rovite, V, Rescenko, R, Peculis, R, Ustinova, M, Zeberg, H, Frithiof, R, Hultstrom, M, Lipcsey, M, Johnson, R, Geschwind, DH, Freimer, N, Butte, MJ, Ding, Y, Chiu, A, Chang, TS, Boutros, P, Moutsianas, L, Caulfield, MJ, Scott, RH, Walker, S, Stuckey, A, Odhams, CA, Rhodes, D, Fowler, T, Rendon, A, Chan, G, Arumugam, P, Karczewski, KJ, Wilson, DJ, Spencer, CA, Crook, DW, Wyllie, DH, O'Connell, AM, Atkinson, EG, Tsuo, K, Baya, N, Turley, P, Gupta, R, Walters, RK, Palmer, DS, Sarma, G, Cheng, N, Lu, W, Churchhouse, C, Goldstein, JI, King, D, Seed, C, Daly, MJ, Bryant, S, Satterstrom, FK, Band, G, Earle, SG, Lin, S-K, Arning, N, Armstrong, J, Rudkin, JK, Callier, S, Cusick, C, Soranzo, N, Zhao, JH, Danesh, J, Di Angelantonio, E, Butterworth, AS, Sun, YV, Huffman, JE, Cho, K, O'Donnell, CJ, Tsao, P, Gaziano, JM, Peloso, G, Ho, Y-L, Mian, M, Scaggiante, F, Chang, X, Glessner, JR, Hakonarson, H, Baillie, JK, McGuigan, PJ, Moore, LSP, Vizcaychipi, MP, Hall, K, Campbell, A, Nichol, A, Ward, G, Page, VJ, Semple, MG, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Aldera, EL, Alegria, A, Angus, B, Ashish, A, Atkinson, D, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Basude, S, Baxter, D, Beadsworth, M, Bernatoniene, J, Berridge, J, Best, N, Bothma, P, Chadwick, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Child, J, Chukkambotla, S, Clark, T, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M-T, Dark, P, Dawson, C, Dervisevic, S, Donnison, P, Douthwaite, S, Drummond, A, DuRand, I, Dushianthan, A, Dyer, T, Evans, C, Eziefula, C, Fegan, C, Finn, A, Fullerton, D, Garg, S, Garg, A, Gkrania-Klotsas, E, Godden, J, Goldsmith, A, Graham, C, Hardy, E, Hartshorn, S, Harvey, D, Havalda, P, Hawcutt, DB, Hobrok, M, Hodgson, L, Hormis, A, Jacobs, M, Jain, S, Jennings, P, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kendall, J, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Laha, S, Laird, S, Larkin, S, Leiner, T, Lillie, P, Limb, J, Linnett, V, Little, J, Lyttle, M, MacMahon, M, MacNaughton, E, Mankregod, R, Masson, H, Matovu, E, McCullough, K, McEwen, R, Meda, M, Mills, GH, Minton, J, Ward, K, Mirfenderesky, M, Mohandas, K, Mok, Q, Moon, J, Moore, E, Morgan, P, Morris, C, Mortimore, K, Moses, S, Mpenge, M, Mulla, R, Murphy, M, Nagel, M, Nagarajan, T, Nelson, M, O'Shea, MK, Otahal, I, Ostermann, M, Pais, M, Panchatsharam, S, Papakonstantinou, D, Paraiso, H, Patel, B, Pattison, N, Pepperell, J, Peters, M, Phull, M, Pintus, S, Pooni, JS, Post, F, Price, D, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Roberts, M, Roberts, D, Rose, A, Rousseau, G, Ryan, B, Saluja, T, Shah, A, Shanmuga, P, Sharma, A, Shawcross, A, Sizer, J, Shankar-Hari, M, Smith, R, Snelson, C, Spittle, N, Staines, N, Stambach, T, Stewart, R, Subudhi, P, Szakmany, T, Tatham, K, Thomas, J, Thompson, C, Thompson, R, Tridente, A, Tupper-Carey, D, Twagira, M, Ustianowski, A, Vallotton, N, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Walden, A, Welters, I, Whitehouse, T, Whittaker, P, Whittington, A, Papineni, P, Wijesinghe, M, Williams, M, Wilson, L, Cole, S, Winchester, S, Wiselka, M, Wolverson, A, Wooton, DG, Workman, A, Yates, B, Young, P, Beale, R, Bretherick, AD, Clohisey, S, Fourman, MH, Furniss, J, Gountouna, E, Grimes, G, Haley, C, Harrison, D, Hayward, C, Keating, S, Klaric, L, Klenerman, P, Law, A, Meynert, AM, Millar, J, Pairo-Castineira, E, Parkinson, N, Ponting, CP, Porteous, DJ, Rawlik, K, Richmond, A, Rowan, K, Russell, CD, Shen, X, Shih, B, Tenesa, A, Vitart, V, Wang, B, Wilson, JF, Wu, Y, Yang, J, Yang, Z, Zechner, M, Zhai, R, Zheng, C, Norman, L, Pius, R, Drake, TM, Fairfield, CJ, Knight, SR, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Leeming, G, Wham, M, Hendry, R, Scott-Brown, J, Begg, C, Hinds, C, Ho, AYW, Horby, PW, Knight, J, Ling, L, Maslove, D, McAuley, D, Montgomery, H, Openshaw, PJM, Summers, C, Walsh, T, Armstrong, L, Bates, H, Dooks, E, Farquhar, F, Hairsine, B, McParland, C, Packham, S, Alldis, Z, Lain, RA-C, Bibi, F, Biddle, J, Blow, S, Bolton, M, Borra, C, Bowles, R, Burton, M, Choudhury, Y, Collier, D, Cox, A, Easthope, A, Ebano, P, Fotiadis, S, Gurasashvili, J, Halls, R, Hartridge, P, Kallon, D, Kassam, J, Lancoma-Malcolm, I, Matharu, M, May, P, Mitchelmore, O, Newman, T, Patel, M, Pheby, J, Pinzuti, I, Prime, Z, Prysyazhna, O, Shiel, J, Taylor, M, Tierney, C, Wood, S, Zak, A, Zongo, O, Forsey, M, Nicholson, A, Riches, J, Vertue, M, Wasson, C, Finn, S, Green, J, Collins, E, King, B, Grauslyte, L, Hussain, M, Pogreban, T, Rosaroso, L, Salciute, E, Franke, G, Wong, J, George, A, Akeroyd, L, Bano, S, Bromley, M, Gurr, L, Lawton, T, Morgan, J, Sellick, K, Warren, D, Wilkinson, B, McGowan, J, Ledgard, C, Stacey, A, Pye, K, Bellwood, R, Bentley, M, Loosley, R, McGuinness, H, Tench, H, Wolf-Roberts, R, Gibson, S, Lyle, A, McNeela, F, Radhakrishnan, J, Hughes, A, Ali, A, Brady, M, Dale, S, Dance, A, Gledhill, L, Greig, J, Hanson, K, Holdroyd, K, Home, M, Kelly, D, Kitson, R, Matapure, L, Melia, D, Mellor, S, Nortcliffe, T, Pinnell, J, Robinson, M, Shaw, L, Shaw, R, Thomis, L, Wilson, A, Wood, T, Bayo, L-A, Merwaha, E, Ishaq, T, Hanley, S, Antcliffe, D, Banach, D, Brett, S, Coghlan, P, Fernandez, Z, Gordon, A, Rojo, R, Arias, SS, Templeton, M, Jha, R, Krishnamurthy, V, Lim, L, Bi, R, Scholefield, B, Ashton, L, Williams, A, Cheyne, C, Saunderson, A, Allan, A, Anderson, F, Kaye, C, Liew, J, Medhora, J, Scott, T, Trumper, E, Botello, A, Polgarova, P, Stroud, K, Meaney, E, Jones, M, Ng, A, Agrawal, S, Pathan, N, White, D, Daubney, E, Elston, K, Parker, R, Reddy, A, Turner-Bone, I, Wilding, L, Harding, P, Jacob, R, Jones, C, Denmade, C, Croft, M, White, I, Griffin, D, Muchenje, N, Mupudzi, M, Partridge, R, Conyngham, J-A, Thomas, R, Wright, M, Corral, MA, Bastion, V, Clarke, D, David, B, Kent, H, Lorusso, R, Lubimbi, G, Murdoch, S, Penacerrada, M, Thomas, A, Valentine, J, Vochin, A, Wulandari, R, Djeugam, B, Dawson, J, Garrioch, S, Tolson, M, Aldridge, J, Martins, LGDA, Carungcong, J, Beavis, S, Dale, K, Gascoyne, R, Hawes, J, Pritchard, K, Stevenson, L, Whileman, A, Cowley, A, Highgate, J, Crawley, R, Crew, A, Cunningham, M, Daniels, A, Harrison, L, Hope, S, Inweregbu, K, Jones, S, Lancaster, N, Matthews, J, Wray, G, Benham, L, Bradshaw, Z, Brown, J, Caswell, M, Melling, S, Preston, S, Slawson, N, Stoddard, E, Warden, S, Combes, E, Joefield, T, Monnery, S, Beech, V, Trotman, S, Hopkins, B, Scriven, J, Thrasyvoulou, L, Willis, H, Anderson, S, Birch, J, Hammerton, K, O'Leary, R, Abernathy, C, Foster, L, Gratrix, A, Martinson, V, Parkinson, P, Stones, E, Carbral-Ortega, L, Kapoor, R, Loader, D, Castle, K, Brandwood, C, Smith, L, Clark, R, Birchall, K, Kolakaluri, L, Baines, D, Sukumaran, A, Mapfunde, I, Meredith, M, Morris, L, Ryan, L, Clark, A, Sampson, J, Peters, C, Dent, M, Langley, M, Wei, S, Andrew, A, Chablani, M, Kirkby, A, Netherton, K, Bates, M, Dasgin, J, Gill, J, Nilsson, A, Apetri, E, Basikolo, C, Blackledge, B, Catlow, L, Charles, B, Doonan, R, Harris, J, Harvey, A, Horner, D, Knowles, K, Lomas, D, Lyons, C, Marsden, T, McLaughlan, D, McMorrow, L, Pendlebury, J, Perez, J, Poulaka, M, Proudfoot, N, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Michael, A, Collis, M, Clark, M, Coulding, M, Jude, E, McCormick, J, Mercer, O, Potla, D, Rehman, H, Savill, H, Turner, V, Davey, M, Golden, D, Seaman, R, Hunt, J, Dearden, J, Dobson, E, Mulcahy, M, Munt, S, O'Connor, G, Philbin, J, Rishton, C, Tully, R, Winnard, S, Cagova, L, Fofano, A, Garner, L, Holcombe, H, Mepham, S, Mitchell, AM, Mwaura, L, Praman, K, Zamikula, J, Bercades, G, Brealey, D, Hass, I, MacCallum, N, Martir, G, Raith, E, Reyes, A, Smyth, D, Taylor, A, Hughes, RA, Thomas, H, Rees, A, Duskova, M, Phipps, J, Brooks, S, Edwards, M, Alexander, P, Allen, S, Bradley-Potts, J, Brantwood, C, Egan, J, Felton, T, Padden, G, Ward, L, Moss, S, Glasgow, S, Beesley, K, Board, S, Kubisz-Pudelko, A, Lewis, A, Perry, J, Pippard, L, Wood, D, Buckley, C, Brown, A, Gregory, J, O'Connell, S, Smith, T, Belagodu, Z, Fuller, B, Gherman, A, Olufuwa, O, Paramsothy, R, Stuart, C, Oakley, N, Kamundi, C, Tyl, D, Collins, K, Silva, P, Taylor, J, King, L, Coates, C, Crowley, M, Wakefield, P, Beadle, J, Johnson, L, Sargeant, J, Anderson, M, Jardine, C, Williams, D, Parris, V, Quaid, S, Watson, E, Melville, J, Naisbitt, J, Joseph, R, Lazo, M, Walton, O, Neal, A, Hill, M, Kannan, T, Wild, L, Allan, E, Darlington, K, Davies, F, Easton, J, Kumar, S, Lean, R, Menzies, D, Pugh, R, Qiu, X, Davies, L, Williams, H, Scanlon, J, Davies, G, Mackay, C, Lewis, J, Rees, S, Coetzee, S, Gales, A, Raj, M, Sell, C, Langton, H, Watters, M, Novis, C, Arbane, G, Bociek, A, Campos, S, Grau, N, Jones, TO, Lim, R, Marotti, M, Whitton, C, Barron, A, Collins, C, Kaul, S, Passmore, H, Prendergast, C, Reed, A, Rogers, P, Shokkar, R, Woodruff, M, Middleton, H, Polgar, O, Nolan, C, Thwaites, V, Mahay, K, Sri-Chandana, C, Scherewode, J, Stephenson, L, Marsh, S, Bancroft, H, Bellamy, M, Carmody, M, Daglish, J, Moore, F, Rhodes, J, Sangombe, M, Kadiri, S, Ayers, A, Harrison, W, North, J, Cavazza, A, Cockrell, M, Corcoran, E, Depante, M, Finney, C, Jerome, E, McPhail, M, Nayak, M, Noble, H, O'Reilly, K, Pappa, E, Saha, R, Saha, S, Smith, J, Knighton, A, Gill, M, Paul, P, Ratnam, V, Shelton, S, Wynter, I, Baptista, D, Crowe, R, Fernandes, R, Herdman-Grant, R, Joseph, A, Loveridge, A, McKenley, I, Morino, E, Naranjo, A, Simms, R, Sollesta, K, Swain, A, Venkatesh, H, Khera, J, Fox, J, Barber, R, Hewitt, C, Hilldrith, A, Jackson-Lawrence, K, Shepardson, S, Wills, M, Butler, S, Tavares, S, Cunningham, A, Hindale, J, Arif, S, George, L, Twiss, S, Wright, D, Holland, M, Keenan, N, Lyons, M, Wassall, H, Marsh, C, Mahenthran, M, Carter, E, Kong, T, Adanini, O, Bhatia, N, Msiska, M, Mew, L, Mwaura, E, Williams, F, Wren, L, Sutherland, S-B, Battle, C, Brinkworth, E, Harford, R, Murphy, C, Newey, L, Rees, T, Arnold, S, Hardy, J, Houlden, H, Moncur, E, Tariq, A, Tucci, A, Convery, K, Fottrell-Gould, D, Hudig, L, Keshet-Price, J, Randell, G, Stammers, K, Abdelrazik, M, Bakthavatsalam, D, Elhassan, M, Ganesan, A, Haldeos, A, Moreno-Cuesta, J, Purohit, D, Vincent, R, Xavier, K, Rohit, K, Alasdair, F, Saleem, M, David, C, Jenkins, S, Lamond, Z, Wall, A, Reynolds, J, Campbell, H, Thompsom, M, Dodds, S, Duffy, S, Butcher, D, O'Sullivan, S, Butterworth-Cowin, N, Deacon, B, Hibbert, M, Pothecary, C, Tetla, D, Woodford, C, Durga, L, Kennard-Holden, G, de Gordoa, LO-R, Peasgood, E, Phillips, C, Skinner, D, Gaylard, J, Mullan, D, Newman, J, Davies, E, Roche, L, Sathe, S, Brimfield, L, Daly, Z, Pogson, D, Rose, S, Collins, A, Khaliq, W, Gude, ET, Allen, L, Beranova, E, Crisp, N, Deery, J, Hazelton, T, Knight, A, Price, C, Tilbey, S, Turki, S, Turney, S, Giles, J, Booth, S, Bell, G, English, K, Katary, A, Wilcox, L, Campbell, R, Clarke, N, Whiteside, J, Mascarenhas, M, Donaldson, A, Matheson, J, Barrett, F, O'Hara, M, O'Keefe, L, Bradley, C, Walker, R, Maynard, V, Patel, T, Smith, M, Kazi, A, Hartley, J, Dykes, J, Hijazi, M, Keith, S, Khan, M, Ryan-Smith, J, Springle, P, Truman, N, Saad, S, Coleman, D, Fine, C, Matt, R, Gay, B, Dalziel, J, Ali, S, Goodchild, D, Harling, R, Bhatterjee, R, Goddard, W, Davison, C, Duberly, S, Hargreaves, J, Bolton, R, Verlander, M, Blackman, H, Creagh-Brown, B, Donlon, S, Michalak-Glinska, N, Mtuwa, S, Pristopan, V, Salberg, A, Smith, E, Stone, S, Piercy, C, Verula, J, Burda, D, Montaser, R, Harden, L, Mayangao, I, Marriott, C, Bradley, P, Harris, C, Cooper, J, Finch, C, Liderth, S, Quinn, A, Waddington, N, Fidler, K, Tagliavini, E, Donnelly, K, Abel, L, Brett, M, Digby, B, Gemmell, L, Hornsby, J, MacGoey, P, O'Neil, P, Price, R, Rodden, N, Rooney, K, Sundaram, R, Thomson, N, Flanagan, R, Hughes, G, Latham, S, McKenna, E, Anderson, J, Hull, R, Rhead, K, Branney, D, Frankham, J, Pitts, S, White, N, Cristiano, D, Dormand, N, Farzad, Z, Gummadi, M, Liyanage, K, Patel, BV, Salmi, S, Sloane, G, Varghese, M, Zborowski, AC, Bean, S, Burt, K, Spivey, M, Eastgate-Jackson, C, Filipe, H, Martin, D, Maharajh, A, Garcia, SM, De Neef, M, Lynch, C, Howe, GS, Singh, J, Turner, K, Ellis, H, Stroud, N, Cherian, S, Cutler, S, Heron, AE, Roynon-Reed, A, Williams, G, Richards, O, Cheema, Y, Ahmad, N, Barker, J, Bauchmuller, K, Bird, S, Cawthron, K, Harrington, K, Jackson, Y, Kibutu, F, Lenagh, B, Masuko, S, Raithatha, A, Wiles, M, Willson, J, Newell, H, Lye, A, Nwafor, L, Jarman, C, Rowland-Jones, S, Foote, D, Cole, J, Watson, J, Hesseldon, L, Macharia, I, Chetam, L, Ford, A, Housley, K, Milner, L, Hanratty, H, Trower, H, Phillips, P, Oxspring, S, Donne, B, Bevan, E, Trodd, D, Watson, G, Brown, CW, Bunni, L, Jennings, C, Latif, M, Marshall, R, Subramanian, G, Bandla, N, Gellamucho, M, Davies, M, Trim, F, Eapen, B, Ahmed, C, Baines, B, Clamp, S, Colley, J, Haq, R, Hayes, A, Hulme, J, Joseph, S, Kumar, R, Maqsood, Z, Purewal, M, Chandler, B, Elliott, K, Mallinson, J, Turnbull, A, Dent, K, Horsley, E, Akhtar, MN, Pearson, S, Potoczna, D, Spencer, S, Blakemore, H, Borislavova, B, Faulkner, B, Gendall, E, Goff, E, Hayes, K, Thomas, M, Worner, R, Smith, K, Stephens, D, Delgado, CC, Dawson, D, Ding, L, Durrant, G, Ezeobu, O, Farnell-Ward, S, Harrison, A, Kanu, R, Leaver, S, Maccacari, E, Manna, S, Saluzzio, RP, Queiroz, J, Samakomva, T, Sicat, C, Texeira, J, Da Gloria, EF, Lisboa, A, Rawlins, J, Mathew, J, Kinch, A, Hurt, WJ, Shah, N, Clark, V, Thanasi, M, Yun, N, Patel, K, Crickmore, V, Debreceni, G, Wilkins, J, Nicol, L, Burn, I, Hambrook, G, Manso, K, Penn, R, Shanmugasundaram, P, Tebbutt, J, Thornton, D, Rostron, A, Roy, A, Woods, L, Cornell, S, Wakinshaw, F, Rogerson, K, Jarmain, J, Anderson, P, Archer, K, Austin, K, Davis, C, Durie, A, Kelsall, O, Thrush, J, Vigurs, C, Wood, H-L, Tranter, H, Cowley, N, McAlindon, M, Digby, S, Low, E, Morgan, A, Cother, N, Rankin, T, Clayton, S, McCurdy, A, Allibone, S, Mary-Genetu, R, Patel, A, Mac, A, Murphy, A, Mahjoob, P, Nazari, R, Worsley, L, Fagan, A, Ali, IMA, Beaumont, K, Blunt, M, Coton, Z, Curgenven, H, Elsaadany, M, Fernandes, K, Ally, SM, Rangarajan, H, Sarathy, V, Selvanayagam, S, Vedage, D, White, M, Fernandez-Roman, J, Hamilton, DO, Johnson, E, Johnston, B, Martinez, ML, Mulla, S, Shaw, D, Waite, AAC, Waugh, V, Welters, ID, Williams, K, Bemand, T, Black, E, Dela Rosa, A, Howle, R, Jhanji, S, Baikady, RR, Tatham, KC, Thomas, B, Halkes, M, Mercer, P, Thornton, L, West, J, Baird, T, Ruddy, J, Reece-Anthony, R, Birt, M, Cowton, A, Kay, A, Kent, M, Potts, K, Wilkinson, A, Naylor, S, Brown, E, Purvis, S, Davies, R, Duffin, D, Hill, H, Player, B, Thomas, E, Beith, CM, Black, K, Clements, S, Morrison, A, Strachan, D, Clarkson, M, D'Sylva, S, Norman, K, Coventry, T, Fowler, S, McGregor, A, Brady, A, Chan, R, McIvor, S, Prady, H, Whittle, H, Mathew, B, Clapham, M, Harper, R, Poultney, U, Rice, P, Mutch, R, Baird, Y, Butler, A, Chadbourn, I, Folkes, L, Fox, H, Gardner, A, Gomez, R, Hobden, G, King, K, Margarson, M, Martindale, T, Meadows, E, Raynard, D, Thirlwall, Y, Helm, D, Margalef, J, Greer, S, Shuker, K, Smuts, S, Duffield, J, Smith, O, Mallon, L, Claire, W, Birkinshaw, I, Carter, J, Howard, K, Ingham, J, Joy, R, Pearson, H, Roche, S, Scott, Z, Knights, E, Price, A, Thorpe, C, Abraheem, A, Bamford, P, Cawley, K, Dunmore, C, Faulkner, M, Girach, R, Jeffrey, H, Jones, R, London, E, Nagra, I, Nasir, F, Sainsbury, H, Smedley, C, Khade, R, Sundar, A, Tsinaslanidis, G, Behan, T, Burnett, C, Hatton, J, Heeney, E, Mitra, A, Newton, M, Pollard, R, Stead, R, Bough, L, Goodsell, J, Tutton, R, Williams, P, Williams, S, Winter-Goodwin, B, Auld, F, Donnachie, J, Edmond, I, Prentice, L, Runciman, N, Salutous, D, Symon, L, Todd, A, Turner, P, Short, A, Sweeney, L, Murdoch, E, Senaratne, D, Burns, K, Higham, A, Anderson, T, Hawcutt, D, O'Malley, L, Rad, L, Rogers, N, Saunderson, P, Allison, KS, Afolabi, D, Whitbread, J, Jones, D, Dore, R, Lankester, L, Nikitas, N, Wells, C, Stowe, B, Spencer, K, Cathcart, S, Duffy, K, Puxty, A, Puxty, K, Turner, L, Ireland, J, Semple, G, Barry, P, Hilltout, P, Evitts, J, Tyler, A, Waldron, J, Irvine, V, Shelley, B, Akinkugbe, O, Bamford, A, Beech, E, Belfield, H, Bell, M, Davies, C, Jones, GAL, McHugh, T, Meghari, H, O'Neill, L, Peters, MJ, Ray, S, Tomas, AL, Gorman, C, Gupta, A, Timlick, E, Brady, R, Bonner, S, Hugill, K, Jones, J, Liggett, S, Bashyal, A, Davidson, N, Hutton, P, McKechnie, S, Wilson, J, Flint, N, Rekha, P, Hales, D, Cruz, C, Gopal, S, Harris, N, Lake, V, Metherell, S, Radford, E, Clement, I, Gulati, A, Hays, C, Webster, K, Hudson, A, Webster, A, Stephenson, E, McCormack, L, Slater, V, Nixon, R, Hanson, H, Fearby, M, Kelly, S, Bridgett, V, Robinson, P, Almaden-Boyle, C, Austin, P, Cabrelli, L, Casey, M, Chapman, S, Whyte, C, Brayne, A, Fisher, E, Jackson, P, Kaye, D, Love, N, Parkin, J, Tuckey, V, van Koutrik, L, Carter, S, Andrew, B, Findlay, L, Adams, K, Bruce, M, Connolly, K, Duncan, T, Michael, HT, Lindergard, G, Hey, S, Fox, C, Alfonso, J, Durrans, LJ, Guerin, J, Hruska, M, Eltayeb, A, Lamb, T, Hodgkiss, T, Cooper, L, Rothwell, J, Dennis, C, Srikaran, S, Sukha, A, Davies, K, O'Brien, L, Omar, Z, Perkins, E, Lewis, T, Sutherland, I, Brooke, H, Buckley, S, Suarez, JC, Charlesworth, R, Hansson, K, Norris, J, Poole, A, Sandhu, R, Sloan, B, Smithson, E, Thirumaran, M, Wagstaff, V, Metcalfe, A, Camsooksai, J, Humphrey, C, Wadams, B, Death, Y, Adams, C, Agasou, A, Arden, T, Bowes, A, Boyle, P, Beekes, M, Button, H, Capps, N, Carnahan, M, Carter, A, Childs, D, Donaldson, D, Hard, K, Hurford, F, Hussain, Y, Javaid, A, Jose, S, Leigh, M, Martin, T, Millward, H, Motherwell, N, Rikunenko, R, Stickley, J, Summers, J, Ting, L, Tivenan, H, Tonks, L, Wilcox, R, Bokhari, M, Lucas, R, McCormick, W, Ritzema, J, Sanderson, A, Wild, H, Baxter, N, Henderson, S, Kennedy-Hay, S, Rooney, L, Sim, M, McCreath, G, Brunton, M, Caterson, J, Coles, H, Frise, M, Rai, SG, Keating, L, Tilney, E, Bartley, S, Bhuie, P, Downes, C, Holding, K, Riches, K, Hilton, M, Hayman, M, Subramanian, D, Daniel, P, Zitter, L, Benyon, S, Marriott, S, Park, L, Keenan, S, Gordon, E, Quinn, H, Baines, K, Andrew, G, Barclay, L, Callaghan, M, Clark, S, Hope, D, Marshall, L, McCulloch, C, Briton, K, Singleton, J, Birch, S, Simpson, K, Craig, J, Demetriou, C, Eckbad, C, Hierons, S, Howie, L, Mitchard, S, Ramos, L, Serrano-Ruiz, A, White, K, Kelly, F, Amin, V, Anastasescu, E, Anumakonda, V, Karthik, K, Kausar, R, Reid, K, Imeson-Wood, J, Bellini, A, Bryant, J, Pickard, A, Roe, N, Sowter, J, Howlett, A, Criste, K, Cusack, R, Golder, K, Golding, H, Jones, O, Leggett, S, Male, M, Marani, M, Prager, K, Williams, T, Roberts, B, Salmon, K, Gondo, P, Hadebe, B, Kayani, A, Masunda, B, Ahmed, A, Morris, A, Jakkula, S, Long, K, Whiteley, S, Wilby, E, Ogg, B, Moultrie, S, Odam, M, Bewley, J, Garland, Z, Grimmer, L, Gumbrill, B, Sweet, K, Webster, D, Efford, G, Bennett, S, Goodwin, E, Jackson, M, Kent, A, Tibke, C, Woodyatt, W, Zaki, A, Daniel, A, Finn, J, Bremmer, P, Allan, J, Geary, T, Houston, G, Meikle, A, O'Brien, P, Bell, D, Boyle, R, Douglas, K, Glass, L, Lee, E, Lennon, L, Rattray, A, Charnock, R, McFarland, D, Cosgrove, D, Attwood, B, Parsons, P, Carmody, S, Oblak, M, Popescu, M, Thankachen, M, Baruah, R, Morris, S, Ferguson, S, Shepherd, A, Altabaibeh, A, Alvaro, A, Gilbert, K, Ma, L, Mostoles, L, Parmar, C, Jetha, C, Booker, L, Pratley, A, Cosier, T, Millen, G, Schumacher, N, Weston, H, Rand, J, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Docherty, AB, Dunning, J, Filipe, ADS, Fletcher, T, Green, CA, Harrison, EM, Hiscox, JA, Ijaz, S, Khoo, S, Lim, WS, Mentzer, AJ, Merson, L, Noursadeghi, M, Moore, SC, Palmarini, M, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Robertson, DL, Sancho-Shimizu, V, Scott, JT, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Tedder, RS, Thomson, EC, Thompson, AAR, Thwaites, RS, Turtle, LCW, Gupta, RK, Palmieri, C, Swann, OV, Zambon, M, Dumas, M-E, Griffin, JL, Takats, Z, Chechi, K, Andrikopoulos, P, Osagie, A, Olanipekun, M, Liggi, S, Lewis, MR, Correia, GDS, Sands, CJ, Takis, P, Maslen, L, Greenhalf, W, Shaw, V, McDonald, SE, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bakshi, S, Barlow, SL, Booth, L, Brennan, B, Bullock, K, Catterall, BWA, Clark, JJ, Clarke, EA, Cox, H, Dincarslan, O, Dunn, C, Dyer, P, Elliott, A, Evans, A, Finch, L, Fisher, LWS, Foster, T, Garcia-Dorival, I, Gunning, P, Hartley, C, Jensen, RL, Jones, CB, Jones, TR, Khandaker, S, Kiy, RT, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, LA, Mancini, M, McDonald, S, McEvoy, L, McLauchlan, J, Metelmann, S, Miah, NS, Middleton, J, Mitchell, J, Murphy, EG, Penrice-Randal, R, Pilgrim, J, Prince, T, Reynolds, W, Ridley, PM, Sales, D, Shaw, VE, Shears, RK, Small, B, Subramaniam, KS, Szemiel, A, Taggart, A, Tanianis-Hughes, J, Trochu, E, van Tonder, L, Wilcock, E, Zhang, JE, Flaherty, L, Maziere, N, Cass, E, Carracedo, AD, Carlucci, N, Holmes, A, Massey, H, Murphy, L, Wrobel, N, McCafferty, S, Morrice, K, MacLean, A, Armstrong, R, Boz, C, Coutts, A, Cullum, L, Day, N, Donnelly, L, Duncan, E, Fawkes, A, Finernan, P, Gilchrist, T, Golightly, A, Hafezi, K, Law, D, Law, R, Law, S, Macgillivray, L, Maclean, A, Mal, H, Mcmaster, E, Meikle, J, Oosthuyzen, W, Paterson, T, Stenhouse, A, Swets, M, Szoor-McElhinney, H, Taneski, F, Wackett, T, Ward, M, Weaver, J, Coyle, J, Gallagher, B, Lidstone-Scott, R, Hamilton, D, Schon, K, Furlong, A, Biggs, H, Griffiths, F, Andrews, E, Brickell, K, Smyth, M, Carson, G, Hardwick, H, Donohue, C, Initiative, CHG, Team, AC, Grp, NS-CS, Force, HCT, Task, HGC, FHoGID, RegCOVID, P-PredictUs, SeroCOVID, CRiPSI, Team, GHR, Working, UCLAHATLASDM, COVID-19 Host Genetics initiative, including authors, Amsterdam Neuroscience - Complex Trait Genetics, Complex Trait Genetics, Internal Medicine, Epidemiology, Oral and Maxillofacial Surgery, UK Research and Innovation, NIHR, UKRI MRC COVID-19 Rapid Response Call, Niemi, Mari E. K., Karjalainen, Juha, Liao, Rachel G., Neale, Benjamin M., Daly, Mark, Ganna, Andrea, Pathak, Gita A., Andrews, Shea J., Kanai, Masahiro, Veerapen, Kumar, Fernandez-Cadenas, Israel, Schulte, Eva C., Striano, Pasquale, Marttila, Minttu, Minica, Camelia, Marouli, Eirini, Karim, Mohd Anisul, Wendt, Frank R., Savage, Jeanne, Sloofman, Laura, Butler-Laporte, Guillaume, Kim, Han-Na, Kanoni, Stavroula, Okada, Yukinori, Byun, Jinyoung, Han, Younghun, Uddin, Mohammed Jashim, Smith, George Davey, Willer, Cristen J., Buxbaum, Joseph D., Mehtonen, Juha, Finucane, Hilary, Cordioli, Mattia, Martin, Alicia R., Zhou, Wei, Pasaniuc, Bogdan, Julienne, Hanna, Aschard, Hugue, Shi, Huwenbo, Yengo, Loic, Polimanti, Renato, Ghoussaini, Maya, Schwartzentruber, Jeremy, Dunham, Ian, Chwialkowska, Karolina, Francescatto, Margherita, Trankiem, Amy, Balaconis, Mary K., Davis, Lea, Lee, Sulggi, Priest, Jame, Renieri, Alessandra, Sankaran, Vijay G., van Heel, David, Deelen, Patrick, Richards, J. Brent, Nakanishi, Tomoko, Biesecker, Le, Kerchberger, V. Eric, Baillie, J. Kenneth, Mari, Francesca, Bernasconi, Anna, Baillie, Stefano Ceri, Canakoglu, Arif, Wolford, Brooke, Faucon, Annika, Dutta, Atanu Kumar, Schurmann, Claudia, Harry, Emi, Birney, Ewan, Nguyen, Huy, Nasir, Jamal, Kaunisto, Mari, Solomonson, Matthew, Dueker, Nicole, Vadgama, Nirmal, Limou, Sophie, Rahmouni, Souad, Mbarek, Hamdi, Darwish, Dima, Uddin, Md Mesbah, Albertos, Raquel, Pérez-Tur, Jordi, Li, Ruolin, Folkersen, Lasse, Moltke, Ida, Koelling, Nil, Teumer, Alexander, Kousathanas, Athanasio, Utrilla, Alicia, Verdugo, Ricardo A., Zárate, Ruth, Medina-Gómez, Carolina, Gómez-Cabrero, David, Carnero-Montoro, Elena, Cadilla, Carmen L., Moreno-Estrada, André, Garmendia, Adriana, Moya, Leire, Sedaghati-Khayat, Bahar, Boua, Palwendé Romuald, Favé, Marie-Julie, Francioli, Laurent, Lemaçon, Audrey, Migeotte, Isabelle, Patel, Sanjay, Varnai, Reka, Szentpeteri, Jozsef L., Sipeky, Csilla, Colombo, Francesca, von Hohenstaufen, Kathrin, Lio, Pietro, Vallerga, Costanza, Wang, Qingbo, Tanigawa, Yosuke, Im, Hogune, Han, Chulho, Song, Han, Lim, Jiwoo, Lee, Younhe, Kim, Sugyeong, Im, Sangyoon, Atanasovska, Biljana, Ahmad, Hajar Fauzan, Boer, Cindy, Jansen, Philip, Franke, Lude, Kaja, Elżbieta, Pasko, Dorota, Kennis-Szilagyi, Ingrid, Kornilov, Sergey A., Prijatelj, Vid, Prokić, Ivana, Sivanadhan, Ilangkumaran, Perumal, Sarala, Esmaeeli, Sahar, Pearson, Nathaniel M., Auton, Adam, Shelton, Janie F., Shastri, Anjali J., Filshtein-Sonmez, Teresa, Coker, Daniella, Symons, Antony, Esparza-Gordillo, Jorge, Aslibekyan, Stella, O’Connell, Jared, Ye, Chelsea, Weldon, Catherine H., Perera, Minoli, O’Leary, Kevin, Tuck, Matthew, O’Brien, Travi, Meltzer, David, O’Donnell, Peter, Nutescu, Edith, Yang, Guang, Alarcon, Cristina, Herrmann, Stefanie, Mazurek, Sophia, Banagan, Jeff, Hamidi, Zacharia, Barbour, April, Raffat, Noora, Moreno, Diana, Friedman, Paula, Ferwerda, Bart, van de Beek, Diederik, Brouwer, Matthijs C., Vlaar, Alexander P. J., Wiersinga, W. Joost, Posthuma, Danielle, Tissink, Elleke, Koos Zwinderman, A. H., Uffelmann, Emil, van Agtmael, Michiel, Algera, Anne Geke, van Baarle, Frank, Bax, Diane, Beudel, Martijn, Jan Bogaard, Harm, Bomers, Marije, Bonta, Peter I., Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Bugiani, Marianna, Bulle, Esther, Chouchane, Osoul, Cloherty, Alex, Dongelmans, Dave, Elbers, Paul, Fleuren, Luca, Geerlings, Suzanne, Geerts, Bart, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Marku, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, van Mourik, Niel, Nellen, Jeannine, Nossent, Esther J., Paulus, Frederique, Peters, Edgar, van der Poll, Tom, Preckel, Bennedikt, Prins, Jan M., Raasveld, Jorinde, Reijnders, Tom, Schinkel, Michiel, Schultz, Marcus J., Schuurman, Alex, Sigaloff, Kim, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa, van der Valk, Marc, Veelo, Denise, de Vries, Heder, van Vugt, Michèle, Wouters, Dorien, Minnaar, René P., Kromhout, Adrie, van Uffelen, Kees W. J., Wolterman, Ruud A., Roberts, Genevieve, Park, Danny, Ball, Catherine A., Coignet, Marie, Mccurdy, Shannon, Knight, Spencer, Partha, Raghavendran, Rhead, Brooke, Zhang, Miao, Berkowitz, Nathan, Gaddis, Michael, Noto, Keith, Ruiz, Luong, Pavlovic, Milo, Hong, Eurie L., Rand, Kristin, Girshick, Ahna, Guturu, Harendra, Baltzell, Asher Haug, Guntz, Julien, Beguin, Yve, Pigazzini, Sara, Nkambule, Lindokuhle, Bouysran, Youssef, Busson, Adeline, Peyrassol, Xavier, Wilkin, Françoise, Pichon, Bruno, Smits, Guillaume, Vandernoot, Isabelle, Goffard, Jean-Christophe, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gille, Guiot, Julien, Jadot, Laurent, Azarzar, Samira, Dellot, Patricia, Gofflot, Stéphanie, Claassen, Sabine, Bertrand, Axelle, Parzibut, Gille, Clarinval, Mathilde, Moermans, Catherine, Malaise, Olivier, El Kandoussi, Kamilia, Thonon, Raphaël, Huynen, Pascale, Mesdagh, Alyssia, Melo, Sofia, Jacques, Nicola, Di Valentin, Emmanuel, Giroule, Françoi, Collignon, Alice, Radermecker, Coraline, Lebrun, Marielle, Perée, Hélène, Latour, Samuel, Barada, Olivia, Sanchez, Judit, Josse, Claire, Boujemla, Bouchra, Meunier, Margot, Mariavelle, Emeline, Anania, Sandy, Gazon, Hélène, Juszczak, Danusia, Fadeur, Marjorie, Camby, Séverine, Meuris, Christelle, Thys, Marie, Jacques, Jessica, Henket, Monique, Léonard, Philippe, Frippiat, Frederic, Giot, Jean-Baptiste, Sauvage, Anne-Sophie, Von Frenckell, Christian, Mni, Myriam, Wéry, Marie, Staderoli, Alicia, Belhaj, Yasmine, Lambermont, Bernard, Morrison, David R., Mooser, Vincent, Forgetta, Vincenzo, Li, Rui, Ghosh, Biswarup, Laurent, Laetitia, Belisle, Alexandre, Henry, Danielle, Abdullah, Tala, Adeleye, Olumide, Mamlouk, Noor, Kimchi, Nofar, Afrasiabi, Zaman, Rezk, Nardin, Vulesevic, Branka, Bouab, Meriem, Guzman, Charlotte, Petitjean, Loui, Tselios, Chri, Xue, Xiaoqing, Afilalo, Jonathan, Afilalo, Marc, Oliveira, Maureen, Brenner, Bluma, Brassard, Nathalie, Durand, Madeleine, Schurr, Erwin, Lepage, Pierre, Ragoussis, Jianni, Auld, Daniel, Chassé, Michaël, Kaufmann, Daniel E., Lathrop, G. Mark, Adra, Darin, Davis, Lea K., Cox, Nancy J., Below, Jennifer E., Sealock, Julia M., Faucon, Annika B., Shuey, Megan M., Polikowsky, Hannah G., Petty, Lauren E., Shaw, Douglas M., Chen, Hung-Hsin, Zhu, Wanying, Ludwig, Kerstin U., Schröder, Julia, Maj, Carlo, Rolker, Selina, Nöthen, Markus M., Fazaal, Julia, Keitel, Verena, Jensen, Björn-Erik Ole, Feldt, Torsten, Kurth, Ingo, Marx, Nikolau, Dreher, Michael, Pink, Isabell, Cornberg, Marku, Illig, Thoma, Lehmann, Clara, Schommers, Philipp, Augustin, Max, Rybniker, Jan, Knopp, Lisa, Eggermann, Thoma, Volland, Sonja, Altmüller, Janine, Berger, Marc M., Brenner, Thorsten, Hinney, Anke, Witzke, Oliver, Bals, Robert, Herr, Christian, Ludwig, Nicole, Walter, Jörn, Fuchsberger, Christian, Pattaro, Cristian, De Grandi, Alessandro, Pramstaller, Peter, Emmert, David, Melotti, Roberto, Foco, Luisa, Mascalzoni, Deborah, Gögele, Martin, Domingues, Francisco, Hicks, Andrew, Gignoux, Christopher R., Wicks, Stephen J., Crooks, Kristy, Barnes, Kathleen C., Daya, Michelle, Shortt, Jonathan, Rafaels, Nichola, Chavan, Sameer, Goldstein, David B., Kiryluk, Krzysztof, Sengupta, Soumitra, Chung, Wendy, Reilly, Muredach P., Khan, Atla, Wang, Chen, Povysil, Gundula, Bhardwaj, Nitin, Gharavi, Ali G., Ionita-Laza, Iuliana, Shang, Ning, O’Byrne, Sheila M., Nandakumar, Renu, Menon, Amritha, So, Yat S., Hod, Eldad, Pendrick, Danielle, Park, Soo-Kyung, Kim, Hyung-Lae, Kang, Chang Kyung, Lee, Hyo-Jung, Song, Kyoung-Ho, Jae Yoon, Kyung, Paik, Nam-Jong, Seok, Woojin, Yoon, Heejun, Joo, Eun-Jeong, Chang, Yoosoo, Ryu, Seungho, Park, Wan Beom, Su Park, Jeong, Un Park, Kyoung, Ham, Sin Young, Jung, Jongtak, Kim, Eu Suk, Kim, Hong Bin, Ellinghaus, David, Degenhardt, Frauke, Cáceres, Mario, Juzenas, Simona, Lenz, Tobias L., Albillos, Agustín, Julià, Antonio, Heidecker, Bettina, Garcia, Federico, Kurth, Florian, Tran, Florian, Hanses, Frank, Zoller, Heinz, Holter, Jan C., Fernández, Javier, Sander, Leif Erik, Rosenstiel, Philip, Koehler, Philipp, de Cid, Rafael, Asselta, Rosanna, Schreiber, Stefan, Hehr, Ute, Prati, Daniele, Baselli, Guido, Valenti, Luca, Bujanda, Lui, Banales, Jesus M., Duga, Stefano, D’Amato, Mauro, Romero-Gómez, Manuel, Buti, Maria, Invernizzi, Pietro, Franke, Andre, Hov, Johannes R., Karlsen, Tom H., Folseraas, Trine, Maya-Miles, Dougla, Teles, Ana, Azuure, Clinton, Wacker, Eike Matthia, Uellendahl-Werth, Florian, Elabd, Hesham, Arora, Jatin, Lerga-Jaso, Jon, Wienbrandt, Lar, Rühlemann, Malte Christoph, Wendorff, Mareike, Vadla, May Sissel, Lenning, Ole Bernt, Özer, Onur, Myhre, Ronny, Raychaudhuri, Soumya, Tanck, Anja, Gassner, Christoph, Hemmrich-Stanisak, Georg, Kässens, Jan, Figuera Basso, Maria E., Schulzky, Martin, Wittig, Michael, Braun, Nicole, Wesse, Tanja, Albrecht, Wolfgang, Yi, Xiaoli, Ortiz, Aaron Blandino, Chercoles, Adolfo Garrido, Ruiz, Agustín, Mantovani, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Barreira, Ana, Lleo, Ana, Kildal, Anders Benjamin, Glück, Andrea, Nolla, Anna Carrera, Latiano, Anna, Dyrhol-Riise, Anne Ma, Muscatello, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Karina, Banasik, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Bellinghausen, Carla, Ferrando, Carlo, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Spinner, Christoph D., Lange, Christoph, Hu, Cinzia, Cappadona, Claudio, Bianco, Cristiana, Sancho, Cristina, Lihaug Hoff, Dag Arne, Galimberti, Daniela, Jiménez, David, Pestaña, David, Toapanta, David, Azzolini, Elena, Scarpini, Elio, Helbig, Elisa T., Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Navas, Enrique, Arana, Eunate, Sánchez, Félix García, Ceriotti, Ferruccio, Malvestiti, Francesco, Mesonero, Francisco, Pezzoli, Gianni, Lamorte, Giuseppe, Neb, Holger, My, Ilaria, Hernández, Isabel, de Rojas, Itziar, Galván-Femenia, Iván, Heyckendorf, Jan, Badia, Joan Ramon, Schneider, Jochen, Goikoetxea, Josune, Kraft, Julia, Müller, Karl Erik, Gaede, Karoline I., Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lar, Izquierdo-Sanchez, Laura, Sumoy, Lauro, Lippert, Lena J., Terranova, Leonardo, Garbarino, Lucia, Téllez, Lui, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manoli, Gutiérrez-Stampa, María A., Vehreschild, Maria J. G. T., Marquié, Marta, Castoldi, Massimo, Cecconi, Maurizio, Boada, Mercè, Seilmaier, Michael J., Mazzocco, Michela, Rodríguez-Gandía, Miguel, Ayo, Natale Imaz, Blay, Natalia, Martínez, Nilda, Cornely, Oliver A., Palmieri, Orazio, Tentorio, Paolo, Rodrigues, Pedro M., España, Pedro P., Hoffmann, Per, Bacher, Petra, Suwalski, Phillip, de Pablo, Raúl, Nieto, Rosa, Badalamenti, Salvatore, Ciesek, Sandra, Bombace, Sara, Wilfling, Sibylle, Brunak, Søren, Heilmann-Heimbach, Stefanie, Ripke, Stephan, Bahmer, Thoma, Landmesser, Ulf, Protzer, Ulrike, Rimoldi, Valeria, Skogen, Vegard, Andrade, Victor, Moreno, Victor, Poller, Wolfgang, Farre, Xavier, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, de Salazar, Adolfo, Palom, Adriana, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Zanella, Alberto, Bandera, Alessandra, Nebel, Almut, Biondi, Andrea, Caballero-Garralda, Andrea, Gori, Andrea, Lind, Andrea, Fracanzani, Anna Ludovica, Peschuck, Anna, Pesenti, Antonio, de la Horra, Carmen, Milani, Chiara, Paccapelo, Cinzia, Angelini, Claudio, Cea, Cristina, Muñiz-Diaz, Eduardo, Sandoval, Elena, Calderón, Enrique J., Solligård, Erik, Aziz, Fátima, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Blasi, Francesco, Medrano, Francisco J., Rodriguez-Frias, Francisco, Müller, Fredrik, Grasselli, Giacomo, Costantino, Giorgio, Cardamone, Giulia, Foti, Giuseppe, Matullo, Giuseppe, Kurihara, Hayato, Afset, Jan Egil, Damås, Jan Kristian, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Bergan, Jona, Goerg, Siegfried, Ferrusquía-Acosta, Jose, Quero, Jose Hernández, Delgado, Juan, Guerrero, Juan M., Risnes, Kari, Bettini, Laura Rachele, Moreira, Leticia, Gustad, Lise Tuset, Santoro, Luigi, Scudeller, Luigia, Riveiro-Barciela, Mar, Schaefer, Marco, Carrabba, Maria, Valsecchi, Maria G., Hernandez-Tejero, María, Acosta-Herrera, Marialbert, D’Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Ciccarelli, Michele, Bocciolone, Monica, Miozzo, Monica, Chueca, Natalia, Montano, Nicola, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Castro, Pedro, Ferrer, Ricard, Gualtierotti, Roberta, Gallego-Durán, Rocío, Morilla, Rubén, Haider, Sammra, Marsal, Sara, Aneli, Serena, Pelusi, Serena, Bosari, Silvano, Aliberti, Stefano, Dudman, Susanne, Zheng, Tenghao, Pumarola, Toma, Cejudo, Trinidad Gonzalez, Monzani, Valter, Friaza, Vicente, Peter, Wolfgang, Dopazo, Ximo, May, Sandra, Grimsrud, Marit M., Gudbjartsson, Daniel F., Stefansson, Kari, Sulem, Patrick, Sveinbjornsson, Gardar, Melsted, Pall, Norddahl, Gudmundur, Swerford Moore, Kristjan Helgi, Thorsteinsdottir, Unnur, Holm, Hilma, Alarcón-Riquelme, Marta E., Bernardo, David, Martínez-Bueno, Manuel, Rello, Silvia Rojo, Magi, Reedik, Milani, Lili, Metspalu, Andre, Laisk, Triin, Läll, Kristi, Lepamets, Maarja, Esko, Tõnu, Reimann, Ene, Naaber, Paul, Laane, Edward, Pesukova, Jaana, Peterson, Pärt, Kisand, Kai, Tabri, Jekaterina, Allos, Raili, Hensen, Kati, Starkopf, Joel, Ringmets, Inge, Tamm, Anu, Kallaste, Anne, Alavere, Helene, Metsalu, Kristjan, Puusepp, Mairo, Kristiansson, Kati, Koskelainen, Sami, Perola, Marku, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Rivolta, Carlo, Bochud, Pierre-Yve, Bibert, Stéphanie, Boillat, Noémie, Nussle, Semira Gonseth, Albrich, Werner, Quinodoz, Mathieu, Kamdar, Dhryata, Suh, Noémie, Neofytos, Dionysio, Erard, Véronique, Voide, Cathy, Bochud, P. Y., Rivolta, C., Bibert, S., Quinodoz, M., Kamdar, D., Neofytos, D., Erard, V., Voide, C., Friolet, R., Vollenweider, P., Pagani, J. L., Oddo, M., zu Bentrup, F. Meyer, Conen, A., Clerc, O., Marchetti, O., Guillet, A., Guyat-Jacques, C., Foucras, S., Rime, M., Chassot, J., Jaquet, M., Viollet, R. Merlet, Lannepoudenx, Y., Portopena, L., Desgranges, F., Filippidis, P., Guéry, B., Haefliger, D., Kampouri, E. E., Manuel, O., Munting, A., Papadimitriou-Olivgeris, M., Regina, J., Rochat-Stettler, L., Suttels, V., Tadini, E., Tschopp, J., Van Singer, M., Viala, B., Boillat-Blanco, N., Brahier, T., Hügli, O., Meuwly, J. Y., Pantet, O., Nussle, S. Gonseth, Bochud, M., D’Acremont, V., Younes, S. Estoppey, Albrich, W. C., Suh, N., Cerny, A., O’Mahony, L., von Mering, C., Frischknecht, M., Kleger, G. -R., Filipovic, M., Kahlert, C. R., Wozniak, H., Negro, T. Rochat, Pugin, J., Bouras, K., Knapp, C., Egger, T., Perret, A., Montillier, P., di Bartolomeo, C., Barda, B., Carreras, Anna, Galván-Femenía, Iván, Farré, Xavier, Cortés, Beatriz, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, Gori, Marco, Mondelli, Mario Umberto, Castelli, Francesco, Vaghi, Massimo, Rusconi, Stefano, Montagnani, Francesca, Bargagli, Elena, Franchi, Federico, Mazzei, Maria Antonietta, Cantarini, Luca, Tacconi, Danilo, Feri, Marco, Scala, Raffaele, Spargi, Genni, Nencioni, Cesira, Bandini, Maria, Caldarelli, Gian Piero, Spagnesi, Maurizio, Canaccini, Anna, Ognibene, Agostino, D’Arminio Monforte, Antonella, Girardis, Massimo, Antinori, Andrea, Francisci, Daniela, Schiaroli, Elisabetta, Scotton, Pier Giorgio, Panese, Sandro, Scaggiante, Renzo, Monica, Matteo Della, Capasso, Mario, Fiorentino, Giuseppe, Castori, Marco, Aucella, Filippo, Di Biagio, Antonio, Masucci, Luca, Valente, Serafina, Mandalà, Marco, Zucchi, Patrizia, Giannattasio, Ferdinando, Coviello, Domenico A., Mussini, Cristina, Bosio, Giancarlo, Tavecchia, Luisa, Crotti, Lia, Rizzi, Marco, La Rovere, Maria Teresa, Sarzi-Braga, Simona, Bussotti, Maurizio, Ravaglia, Sabrina, Artuso, Rosangela, Perrella, Antonio, Romani, Davide, Bergomi, Paola, Catena, Emanuele, Vincenti, Antonella, Ferri, Claudio, Grassi, Davide, Pessina, Gloria, Tumbarello, Mario, Di Pietro, Massimo, Sabrina, Ravaglia, Luchi, Sauro, Barbieri, Chiara, Acquilini, Donatella, Andreucci, Elena, Paciosi, Francesco, Segala, Francesco Vladimiro, Tiseo, Giusy, Falcone, Marco, Lista, Mirjam, Poscente, Monica, De Vivo, Oreste, Petrocelli, Paola, Guarnaccia, Alessandra, Baroni, Silvia, Perticaroli, Valentina, Furini, Simone, Dei, Simona, Benetti, Elisa, Picchiotti, Nicola, Sanarico, Maurizio, Ceri, Stefano, Pinoli, Pietro, Raimondi, Francesco, Biscarini, Filippo, Stella, Alessandra, Bergomi, Mattia, Zguro, Kristina, Capitani, Katia, Tanfoni, Marco, Fallerini, Chiara, Daga, Sergio, Baldassarri, Margherita, Fava, Francesca, Frullanti, Elisa, Valentino, Floriana, Doddato, Gabriella, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Lo Rizzo, Caterina, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Di Sarno, Laura, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Iuso, Nicola, Inchingolo, Gabriele, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Zanelli, Giacomo, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennet, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazi, Alessandro, Lorubbio, Maria, Merlini, Esther, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Andretta, Francesca, Gatti, Francesca, Parisi, Saverio Giuseppe, Baratti, Stefano, Piscopo, Carmelo, Russo, Roberta, Andolfo, Immacolata, Iolascon, Achille, Carella, Massimo, Merla, Giuseppe, Squeo, Gabriella Maria, Raggi, Pamela, Marciano, Carmen, Perna, Rita, Bassetti, Matteo, Sanguinetti, Maurizio, Giorli, Alessia, Salerni, Lorenzo, Parravicini, Pierpaolo, Menatti, Elisabetta, Trotta, Tullio, Coiro, Gabriella, Lena, Fabio, Martinelli, Enrico, Mancarella, Sandro, Gabbi, Chiara, Maggiolo, Franco, Ripamonti, Diego, Bachetti, Tiziana, Suardi, Claudia, Parati, Gianfranco, Bottà, Giordano, Di Domenico, Paolo, Rancan, Ilaria, Bianchi, Francesco, Colombo, Riccardo, van Heel, David A., Hunt, Karen A., Trembath, Richard C., Huang, Qin Qin, Martin, Hilary C., Mason, Dan, Trivedi, Bhavi, Wright, John, Finer, Sarah, Griffiths, Christopher J., Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Ashraf, Samina, Breen, Gerome, Chung, Raymond, Curtis, Charles J., Chowdhury, Maharun, Colligan, Grainne, Deloukas, Pano, Durham, Ceri, Griffiths, Chri, Hurles, Matt, Hussain, Shapna, Islam, Kamrul, Khan, Ahsan, Khan, Amara, Lavery, Cath, Lee, Sang Hyuck, Lerner, Robin, Macarthur, Daniel, Maclaughlin, Bev, Martin, Hilary, Miah, Shefa, Newman, Bill, Safa, Nishat, Tahmasebi, Farah, Smith, Albert V., Boughton, Andrew P., Li, Kevin W., Lefaive, Jonathon, Annis, Aubrey, Jannes, Cinthia E., Krieger, Jose E., Pereira, Alexandre C., Velho, Mariliza, Marques, Emanuelle, Lima, Isabella Ramo, Tada, Mauricio Teruo, Valino, Karina, Mccarthy, Mark, Rosenberger, Carrie, Lee, Jong Eun, Chang, Diana, Hammer, Christian, Hunkapiller, Julie, Mahajan, Anubha, Pendergrass, Sarah, Sucheston-Campbell, Lara, Yaspan, Brian, Lee, Hyun Soo, Shin, Eunsoon, Jang, Hye Yoon, Kim, Sunmie, Kym, Sungmin, Kim, Yeon-Sook, Jeong, Hyeongseok, Kwon, Ki Tae, Kim, Shin-Woo, Kim, Jin Yong, Jang, Young Rock, Kim, Hyun ah, Lee, Ji Yeon, Lee, Jeong Eun, Lee, Shinwon, Choe, Kang-Won, Kang, Yu Min, Jee, Sun Ha, Jung, Keum Ji, Parikh, Victoria, Ashley, Euan, Wheeler, Matthew, Rivas, Manuel, Bustamante, Carlo, Pinksy, Benjamin, Febbo, Phillip, Farh, Kyle, Schroth, Gary P., Desouza, Franci, Dalton, Karen, Christle, Jeff, Deboever, Christopher, Szalma, Sándor, Rubinacci, Simone, Delaneau, Olivier, Gorzynski, John, de Jong, Hannah, Sutton, Shirley, Youlton, Nathan, Joshi, Ruchi, Jimenez-Morales, David, Hughes, Christopher, Amar, David, Ioannidis, Alex, Hershman, Steve, Kirillova, Anna, Seo, Kinya, Huang, Yong, Shoura, Massa, Hammond, Nathan, Watson, Nathaniel, Raja, Archana, Huang, Chunhong, Sahoo, Malaya, Wang, Hannah, Zhen, Jimmy, Rakitko, Alexander, Ilinsky, Valery, Yermakovich, Danat, Popov, Iaroslav, Chernitsov, Alexander, Kovalenko, Elena, Krasnenko, Anna, Plotnikov, Nikolay, Stetsenko, Ivan, Kim, Anna, Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Bolze, Alexandre, White, Simon, Washington, Nicole L., Lu, James T., Riffle, Stephen, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Leonetti, Nicole, Sandoval, Efren, Neveux, Iva, Dabe, Shaun, Grzymski, Joseph J., Esteban Miñano, Juan Ignacio, Aguirre, Luis A., López-Collazo, Eduardo, de la Mata Pazos, Manuel, Cerrato, Luciano, Lozano-Rodríguez, Roberto, Avendaño-Ortiz, José, Arcos, Verónica Terrón, Montalbán-Hernández, Karla Marina, Quiroga, Jaime Valentín, Pascual-Iglesias, Alejandro, Maroun-Eid, Charbel, Martín-Quirós, Alejandro, Namkoong, Ho, Imoto, Seiya, Katayama, Kazuhiko, Fukunaga, Koichi, Kitagawa, Yuko, Sato, Toshiro, Hasegawa, Naoki, Kumanogoh, Atsushi, Kimura, Akinori, Ai, Masumi, Tokunaga, Katsushi, Kanai, Takanori, Miyano, Satoru, Ogawa, Seishi, Edahiro, Ryuya, Sonehara, Kyuto, Shirai, Yuya, Ishii, Makoto, Kabata, Hiroki, Masaki, Katsunori, Kamata, Hirofumi, Ikemura, Shinnosuke, Chubachi, Shotaro, Okamori, Satoshi, Terai, Hideki, Tanaka, Hiromu, Morita, Atsuho, Lee, Ho, Asakura, Takanori, Sasaki, Junichi, Morisaki, Hiroshi, Uwamino, Yoshifumi, Nanki, Kosaku, Mikami, Yohei, Tomono, Kazunori, Kato, Kazuto, Matsuda, Fumihiko, Takahashi, Meiko, Hizawa, Nobuyuki, Takeda, Yoshito, Hirata, Haruhiko, Shiroyama, Takayuki, Miyawaki, Satoru, Suzuki, Ken, Maeda, Yuichi, Nii, Takuro, Noda, Yoshimi, Niitsu, Takayuki, Adachi, Yuichi, Enomoto, Takatoshi, Amiya, Saori, Hara, Reina, Takahashi, Kunihiko, Anzai, Tatsuhiko, Hasegawa, Takanori, Ito, Satoshi, Koike, Ryuji, Endo, Akifumi, Uchimura, Yuji, Miyazaki, Yasunari, Honda, Takayuki, Tateishi, Tomoya, Tohda, Shuji, Ichimura, Naoya, Sonobe, Kazunari, Sassa, Chihiro, Nakajima, Jun, Nannya, Yasuhito, Omae, Yosuke, Takahashi, Kazuhisa, Harada, Norihiro, Hiki, Makoto, Takagi, Haruhi, Nakamura, Ai, Tagaya, Etsuko, Kawana, Masatoshi, Arimura, Ken, Ishiguro, Takashi, Takayanagi, Noboru, Isono, Taisuke, Takaku, Yotaro, Takano, Kenji, Anan, Ryusuke, Nakajima, Yukiko, Nakano, Yasushi, Nishio, Kazumi, Ueda, Soichiro, Hayashi, Reina, Tateno, Hiroki, Hase, Isano, Yoshida, Shuichi, Suzuki, Shoji, Mitamura, Keiko, Saito, Fumitake, Ueda, Tetsuya, Azuma, Masanori, Nagasaki, Tadao, Yasui, Yoshinori, Hasegawa, Yoshinori, Mutoh, Yoshikazu, Yoshiyama, Takashi, Shoko, Tomohisa, Kojima, Mitsuaki, Adachi, Tomohiro, Ishikawa, Motonao, Takahashi, Kenichiro, Watanabe, Kazuyoshi, Manabe, Tadashi, Ito, Fumimaro, Fukui, Takahiro, Funatsu, Yohei, Koh, Hidefumi, Hirai, Yoshihiro, Kawashima, Hidetoshi, Narita, Atsuya, Niwa, Kazuki, Sekikawa, Yoshiyuki, Saito, Fukuki, Yoshiya, Kazuhisa, Yoshihara, Tomoyuki, Suzuki, Yusuke, Nakayama, Sohei, Masuzawa, Keita, Nishi, Koichi, Nishitsuji, Masaru, Tani, Maiko, Inoue, Takashi, Hirano, Toshiyuki, Kobayashi, Keigo, Miyazawa, Naoki, Kimura, Yasuhiro, Sado, Reiko, Ogura, Takashi, Kitamura, Hideya, Murohashi, Kota, Nakachi, Ichiro, Baba, Rie, Arai, Daisuke, Fuke, Satoshi, Saito, Hiroshi, Kuwahara, Naota, Fujiwara, Akiko, Okada, Takenori, Baba, Tomoya, Noda, Junya, Mashimo, Shuko, Yagi, Kazuma, Shiomi, Tetsuya, Hashiguchi, Mizuha, Odani, Toshio, Mochimaru, Takao, Oyamada, Yoshitaka, Mori, Nobuaki, Izumi, Namiki, Nagata, Kaoru, Taki, Reiko, Murakami, Koji, Yamada, Mitsuhiro, Sugiura, Hisatoshi, Hayashi, Kentaro, Shimizu, Tetsuo, Gon, Yasuhiro, Fujitani, Shigeki, Tsuchida, Tomoya, Yoshida, Toru, Kagaya, Takashi, Kita, Toshiyuki, Sakagami, Satoru, Kimizuka, Yoshifumi, Kawana, Akihiko, Nakamura, Yoshihiko, Ishikura, Hiroyasu, Takata, Tohru, Kikuchi, Takahide, Taniyama, Daisuke, Nakamura, Morio, Kodama, Nobuhiro, Kaneyama, Yasunari, Maeda, Shunsuke, Nagasaki, Yoji, Okamoto, Masaki, Ishihara, Sayoko, Ito, Akihiro, Chihara, Yusuke, Takeuchi, Mayumi, Onoi, Keisuke, Hashimoto, Naozumi, Wakahara, Keiko, Ando, Akira, Masuda, Makoto, Wakabayashi, Aya, Watanabe, Hiroki, Sageshima, Hisako, Nakada, Taka-Aki, Abe, Ryuzo, Shimada, Tadanaga, Kawamura, Kodai, Ichikado, Kazuya, Nishiyama, Kenta, Yamasaki, Masaki, Hashimoto, Satoru, Kusaka, Yu, Ohba, Takehiko, Isogai, Susumu, Takada, Minoru, Kanda, Hidenori, Komase, Yuko, Sano, Fumiaki, Asano, Koichiro, Oguma, Tsuyoshi, Harada, Masahiro, Takahashi, Takeshi, Shibusawa, Takayuki, Abe, Shinji, Kono, Yuta, Togashi, Yuki, Izumo, Takehiro, Inomata, Minoru, Awano, Nobuyasu, Ogawa, Shinichi, Ogata, Tomouki, Ishihara, Shoichiro, Kanehiro, Arihiko, Ozaki, Shinji, Fuchimoto, Yasuko, Kitagawa, Yuichiro, Yoshida, Shozo, Ogura, Shinji, Nishiyama, Kei, Yoshida, Kousuke, Beppu, Satoru, Fukuyama, Satoru, Eriguchi, Yoshihiro, Yonekawa, Akiko, Inoue, Yoshiaki, Yamagata, Kunihiro, Chiba, Shigeru, Narumoto, Osamu, Nagai, Hideaki, Ooshima, Nobuharu, Motegi, Mitsuru, Sagara, Hironori, Tanaka, Akihiko, Ohta, Shin, Shibata, Yoko, Tanino, Yoshinori, Sato, Yuki, Yamada, Yuichiro, Hashino, Takuya, Shinoki, Masato, Iwagoe, Hajime, Imamura, Tomonori, Umeda, Akira, Shimada, Hisato, Endo, Mayu, Hayashi, Shinichi, Takahashi, Mai, Nakano, Shigefumi, Yatomi, Masakiyo, Maeno, Toshitaka, Ishii, Tomoo, Utsugi, Mitsuyoshi, Ono, Akihiro, Kanaoka, Kensuke, Ihara, Shoichi, Komuta, Kiyoshi, Boezen, Marike, Claringbould, Annique, Lopera, Esteban, Warmerdam, Robert, Vonk, Judith. M., van Blokland, Irene, Lanting, Pauline, Ori, Anil P. S., Obeidat, Ma’En, Hernández Cordero, Ana I., Sin, Don D., Bossé, Yohan, Joubert, Philippe, Hao, Ke, Nickle, David, Timens, Wim, van den Berge, Maarten, Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Perez, Emma F., Zöllner, Sebastian, Wang, Jiongming, Beck, Andrew, Sloofman, Laura G., Ascolillo, Steven, Sebra, Robert P., Collins, Brett L., Levy, Te, Sealfon, Stuart C., Jordan, Daniel M., Thompson, Ryan C., Gettler, Kyle, Chaudhary, Kumardeep, Belbin, Gillian M., Preuss, Michael, Hoggart, Clive, Choi, Sam, Underwood, Slayton J., Salib, Irene, Britvan, Bari, Keller, Katherine, Tang, Lara, Peruggia, Michael, Hiester, Liam L., Niblo, Kristi, Aksentijevich, Alexandra, Labkowsky, Alexander, Karp, Avromie, Zlatopolsky, Menachem, Zyndorf, Marissa, Charney, Alexander W., Beckmann, Noam D., Schadt, Eric E., Abul-Husn, Noura S., Cho, Judy H., Itan, Yuval, Kenny, Eimear E., Loos, Ruth J. F., Nadkarni, Girish N., Do, Ron, O’Reilly, Paul, Huckins, Laura M., Ferreira, Manuel A. R., Abecasis, Goncalo R., Leader, Joseph B., Cantor, Michael N., Justice, Anne E., Carey, Dave J., Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Horowitz, Julie E., Baras, Ari, Gass, Matthew C., Yadav, Ashish, Mirshahi, Tooraj, Jan Hottenga, Jouke, Bartels, Meike, de Geus, Eco J. C., Nivard, Michel G., Verma, Anurag, Ritchie, Marylyn D., Rader, Daniel, Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Zara, Federico, Salpietro, Vincenzo, Scala, Marcello, Iacomino, Michele, Scudieri, Paolo, Bocciardi, Renata, Minetti, Carlo, Riva, Antonella, Vari, Maria Stella, Rahier, Jean-Françoi, Giorgio, Elisa, Carli, Diana, Louis, Edouad, Bulik, Cynthia M., Landén, Mikael, Brusco, Alfredo, Ferrero, Giovanni Battista, Madia, Francesca, Fundín, Bengt, Ismail, Said I., Saad, Chadi, Al-Sarraj, Yaser, Badji, Radja Messai, Al-Muftah, Wadha, Al Thani, Asma, Afifi, Nahla, Klovins, Jani, Rovite, Vita, Rescenko, Raimond, Peculis, Raiti, Ustinova, Monta, Zeberg, Hugo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklo, Johnson, Ruth, Geschwind, Daniel H., Freimer, Nelson, Butte, Manish J., Ding, Yi, Chiu, Alec, Chang, Timothy S., Boutros, Paul, Moutsianas, Louka, Caulfield, Mark J., Scott, Richard H., Walker, Susan, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Fowler, Tom, Rendon, Augusto, Chan, Georgia, Arumugam, Prabhu, Karczewski, Konrad J., Wilson, Daniel J., Spencer, Chris A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikola, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Daly, Mark J., Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicola, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Soranzo, Nicole, Zhao, Jing Hua, Danesh, John, Di Angelantonio, Emanuele, Butterworth, Adam S., Sun, Yan V., Huffman, Jennifer E., Cho, Kelly, O’Donnell, Christopher J., Tsao, Phil, Gaziano, J. Michael, Peloso, Gina, Ho, Yuk-Lam, Mian, Michael, Scaggiante, Federica, Chang, Xiao, Glessner, Joseph R., Hakonarson, Hakon, Mcguigan, Peter J., Prockter Moore, Luke Stephen, Vizcaychipi, Marcela Paola, Hall, Kathryn, Campbell, Andy, Nichol, Ailstair, Ward, Geraldine, Page, Valerie Joan, Semple, Malcolm G., Adeniji, Kayode, Agranoff, Daniel, Agwuh, Ken, Ail, Dhiraj, Aldera, Erin L., Alegria, Ana, Angus, Brian, Ashish, Abdul, Atkinson, Dougal, Bari, Shahedal, Barlow, Gavin, Barnass, Stella, Barrett, Nichola, Bassford, Christopher, Basude, Sneha, Baxter, David, Beadsworth, Michael, Bernatoniene, Jolanta, Berridge, John, Best, Nicola, Bothma, Pieter, Chadwick, David, Brittain-Long, Robin, Bulteel, Naomi, Burden, Tom, Burtenshaw, Andrew, Caruth, Vikki, Chambler, Duncan, Chee, Nigel, Child, Jenny, Chukkambotla, Srikanth, Clark, Tom, Collini, Paul, Cosgrove, Catherine, Cupitt, Jason, Cutino-Moguel, Maria-Teresa, Dark, Paul, Dawson, Chri, Dervisevic, Samir, Donnison, Phil, Douthwaite, Sam, Drummond, Andrew, Durand, Ingrid, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Eziefula, Chi, Fegan, Christopher, Finn, Adam, Fullerton, Duncan, Garg, Sanjeev, Garg, Atul, Gkrania-Klotsas, Effrossyni, Godden, Jo, Goldsmith, Arthur, Graham, Clive, Hardy, Elaine, Hartshorn, Stuart, Harvey, Daniel, Havalda, Peter, Hawcutt, Daniel B., Hobrok, Maria, Hodgson, Luke, Hormis, Anil, Jacobs, Michael, Jain, Susan, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Kegg, Stephen, Kelsey, Michael, Kendall, Jason, Kerrison, Caroline, Kerslake, Ian, Koch, Oliver, Koduri, Gouri, Koshy, George, Laha, Shondipon, Laird, Steven, Larkin, Susan, Leiner, Tama, Lillie, Patrick, Limb, Jame, Linnett, Vanessa, Little, Jeff, Lyttle, Mark, Macmahon, Michael, Macnaughton, Emily, Mankregod, Ravish, Masson, Huw, Matovu, Elijah, Mccullough, Katherine, Mcewen, Ruth, Meda, Manjula, Mills, Gary H., Minton, Jane, Ward, Karl, Mirfenderesky, Mariyam, Mohandas, Kavya, Mok, Quen, Moon, Jame, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Mortimore, Katherine, Moses, Samuel, Mpenge, Mbiye, Mulla, Rohinton, Murphy, Michael, Nagel, Megan, Nagarajan, Thapa, Nelson, Mark, O’Shea, Matthew K., Otahal, Igor, Ostermann, Marlie, Pais, Mark, Panchatsharam, Selva, Papakonstantinou, Danai, Paraiso, Hassan, Patel, Brij, Pattison, Natalie, Pepperell, Justin, Peters, Mark, Phull, Mandeep, Pintus, Stefania, Pooni, Jagtur Singh, Post, Frank, Price, David, Prout, Rachel, Rae, Nikola, Reschreiter, Henrik, Reynolds, Tim, Richardson, Neil, Roberts, Mark, Roberts, Devender, Rose, Alistair, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shah, Aarti, Shanmuga, Prad, Sharma, Anil, Shawcross, Anna, Sizer, Jeremy, Shankar-Hari, Manu, Smith, Richard, Snelson, Catherine, Spittle, Nick, Staines, Nikki, Stambach, Tom, Stewart, Richard, Subudhi, Pradeep, Szakmany, Tama, Tatham, Kate, Thomas, Jo, Thompson, Chri, Thompson, Robert, Tridente, Ascanio, Tupper-Carey, Darell, Twagira, Mary, Ustianowski, Andrew, Vallotton, Nick, Vincent-Smith, Lisa, Visuvanathan, Shico, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Walden, Andrew, Welters, Ingeborg, Whitehouse, Tony, Whittaker, Paul, Whittington, Ashley, Papineni, Padmasayee, Wijesinghe, Meme, Williams, Martin, Wilson, Lawrence, Cole, Sarah, Winchester, Stephen, Wiselka, Martin, Wolverson, Adam, Wooton, Daniel G., Workman, Andrew, Yates, Bryan, Young, Peter, Beale, Rupert, Bretherick, Andrew D., Clohisey, Sara, Fourman, Max Head, Furniss, Jame, Gountouna, Elvina, Grimes, Graeme, Haley, Chri, Harrison, David, Hayward, Caroline, Keating, Sean, Klaric, Lucija, Klenerman, Paul, Law, Andy, Meynert, Alison M., Millar, Jonathan, Pairo-Castineira, Erola, Parkinson, Nichola, Ponting, Chris P., Porteous, David J., Rawlik, Konrad, Richmond, Anne, Rowan, Kathy, Russell, Clark D., Shen, Xia, Shih, Barbara, Tenesa, Albert, Vitart, Veronique, Wang, Bo, Wilson, James F., Wu, Yang, Yang, Jian, Yang, Zhijian, Zechner, Marie, Zhai, Ranran, Zheng, Chenqing, Norman, Lisa, Pius, Riinu, Drake, Thomas M., Fairfield, Cameron J., Knight, Stephen R., Mclean, Kenneth A., Murphy, Derek, Shaw, Catherine A., Dalton, Jo, Girvan, Michelle, Saviciute, Egle, Roberts, Stephanie, Harrison, Janet, Marsh, Laura, Connor, Marie, Halpin, Sophie, Jackson, Clare, Gamble, Carrol, Leeming, Gary, Law, Andrew, Wham, Murray, Hendry, Ro, Scott-Brown, Jame, Begg, Colin, Hinds, Charle, Wai Ho, Antonia Ying, Horby, Peter W., Knight, Julian, Ling, Lowell, Maslove, David, Mcauley, Danny, Montgomery, Hugh, Nichol, Alistair, Openshaw, Peter J. M., Summers, Charlotte, Walsh, Timothy, Armstrong, Lisa, Bates, Hayley, Dooks, Emma, Farquhar, Fiona, Hairsine, Brigid, Mcparland, C., Packham, Sophie, Alldis, Zoe, Astin-Chamberlain, Raine, Bibi, Fatima, Biddle, Jack, Blow, Sarah, Bolton, Matthew, Borra, Catherine, Bowles, Ruth, Burton, Maudrian, Choudhury, Yasmin, Collier, David, Cox, Amber, Easthope, Amy, Ebano, Patrizia, Fotiadis, Stavro, Gurasashvili, Jana, Halls, Rosslyn, Hartridge, Pippa, Kallon, Delordson, Kassam, Jamila, Lancoma-Malcolm, Ivone, Matharu, Maninderpal, May, Peter, Mitchelmore, Oliver, Newman, Tabitha, Patel, Mital, Pheby, Jane, Pinzuti, Irene, Prime, Zoe, Prysyazhna, Oleksandra, Shiel, Julian, Taylor, Melanie, Tierney, Carey, Wood, Suzanne, Zak, Anne, Zongo, Olivier, Forsey, Miranda, Nicholson, Anne, Riches, Joanne, Vertue, Mark, Wasson, Christopher, Finn, Stephanie, Green, Jackie, Collins, Erin, King, Bernadette, Grauslyte, Lina, Hussain, Musarat, Pogreban, Tatiana, Rosaroso, Lace, Salciute, Erika, Franke, George, Wong, Joanna, George, Aparna, Akeroyd, Louise, Bano, Shereen, Bromley, Matt, Gurr, Lucy, Lawton, Tom, Morgan, Jame, Sellick, Kirsten, Warren, Deborah, Wilkinson, Brian, Mcgowan, Janet, Ledgard, Camilla, Stacey, Amelia, Pye, Kate, Bellwood, Ruth, Bentley, Michael, Loosley, Ronda, Mcguinness, Heather, Tench, Helen, Wolf-Roberts, Rebecca, Gibson, Sian, Lyle, Amanda, Mcneela, Fiona, Radhakrishnan, Jayachandran, Hughes, Alistair, Ali, Asifa, Brady, Megan, Dale, Sam, Dance, Annalisa, Gledhill, Lisa, Greig, Jill, Hanson, Kathryn, Holdroyd, Kelly, Home, Marie, Kelly, Diane, Kitson, Ro, Matapure, Lear, Melia, Deborah, Mellor, Samantha, Nortcliffe, Tonicha, Pinnell, Jez, Robinson, Matthew, Shaw, Lisa, Shaw, Ryan, Thomis, Lesley, Wilson, Alison, Wood, Tracy, Bayo, Lee-Ann, Merwaha, Ekta, Ishaq, Tahira, Hanley, Sarah, Antcliffe, David, Banach, Dorota, Brett, Stephen, Coghlan, Phoebe, Fernandez, Ziortza, Gordon, Anthony, Rojo, Roceld, Arias, Sonia Sousa, Templeton, Maie, Jha, Rajeev, Krishnamurthy, Vinodh, Lim, Lai, Bi, Rehana, Scholefield, Barney, Ashton, Lydia, Williams, Alison, Cheyne, Claire, Saunderson, Anne, Allan, Angela, Anderson, Felicity, Kaye, Callum, Liew, Jade, Medhora, Jasmine, Scott, Teresa, Trumper, Erin, Botello, Adriana, Polgarova, Petra, Stroud, Katerina, Meaney, Eoghan, Jones, Megan, Ng, Anthony, Agrawal, Shruti, Pathan, Nazima, White, Deborah, Daubney, Esther, Elston, Kay, Parker, Robert, Reddy, Amie, Turner-Bone, Ian, Wilding, Laura, Harding, Peter, Jacob, Reni, Jones, Cathy, Denmade, Craig, Croft, Maria, White, Ian, Lim, Li, Griffin, Denise, Muchenje, Nycola, Mupudzi, Mcdonald, Partridge, Richard, Conyngham, Jo-Anna, Thomas, Rachel, Wright, Mary, Corral, Maria Alvarez, Bastion, Victoria, Clarke, Daphene, David, Beena, Kent, Harriet, Lorusso, Rachel, Lubimbi, Gamu, Murdoch, Sophie, Penacerrada, Melchizedek, Thomas, Alastair, Valentine, Jennifer, Vochin, Ana, Wulandari, Retno, Djeugam, Brice, Dawson, Joy, Garrioch, Sweyn, Tolson, Melanie, Aldridge, Jonathan, de Almeida Martins, Laura Gome, Carungcong, Jaime, Beavis, Sarah, Dale, Katie, Gascoyne, Rachel, Hawes, Joanne, Pritchard, Kelly, Stevenson, Lesley, Whileman, Amanda, Cowley, Anne, Highgate, Judith, Crawley, Rikki, Crew, Abigail, Cunningham, Mishell, Daniels, Allison, Harrison, Laura, Hope, Susan, Inweregbu, Ken, Jones, Sian, Lancaster, Nicola, Matthews, Jamie, Nicholson, Alice, Wray, Gemma, Benham, Leonie, Bradshaw, Zena, Brown, Joanna, Caswell, Melanie, Melling, Sarah, Preston, Stephen, Slawson, Nicola, Stoddard, Emma, Warden, Scott, Combes, Edward, Joefield, Teishel, Monnery, Sonja, Beech, Valerie, Trotman, Sallyanne, Hopkins, Bridget, Scriven, Jame, Thrasyvoulou, Laura, Willis, Heather, Anderson, Susan, Birch, Janine, Collins, Emma, Hammerton, Kate, O’Leary, Ryan, Abernathy, Caroline, Foster, Louise, Gratrix, Andrew, Martinson, Vicky, Parkinson, Priyai, Stones, Elizabeth, Carbral-Ortega, Llucia, Kapoor, Ritoo, Loader, David, Castle, Karen, Brandwood, Craig, Smith, Lara, Clark, Richard, Birchall, Katie, Kolakaluri, Laurel, Baines, Deborah, Sukumaran, Anila, Mapfunde, Isheunesu, Meredith, Megan, Morris, Lucy, Ryan, Lucy, Clark, Amy, Sampson, Julia, Peters, Cecilia, Dent, Martin, Langley, Margaret, Ashraf, Saima, Wei, Shuying, Andrew, Angela, Chablani, Manish, Kirkby, Amy, Netherton, Kimberley, Bates, Michelle, Dasgin, Jo, Gill, Jaspret, Nilsson, Annette, Apetri, Elena, Basikolo, Cathrine, Blackledge, Bethan, Catlow, Laura, Charles, Bethan, Doonan, Reece, Harris, Jade, Harvey, Alice, Horner, Daniel, Knowles, Karen, Lee, Stephanie, Lomas, Diane, Lyons, Chloe, Marsden, Tracy, Mclaughlan, Danielle, Mcmorrow, Liam, Pendlebury, Jessica, Perez, Jane, Poulaka, Maria, Proudfoot, Nicola, Slaughter, Melanie, Slevin, Kathryn, Thomas, Vicky, Walker, Danielle, Michael, Angiy, Collis, Matthew, Clark, Martyn, Coulding, Martina, Jude, Edward, Mccormick, Jacqueline, Mercer, Oliver, Potla, Darsh, Rehman, Hafiz, Savill, Heather, Turner, Victoria, Davey, Miriam, Golden, David, Seaman, Rebecca, Hunt, Jodie, Dearden, Joy, Dobson, Emma, Mulcahy, Michelle, Munt, Sheila, O’Connor, Grainne, Philbin, Jennifer, Rishton, Chloe, Tully, Redmond, Winnard, Sarah, Cagova, Lenka, Fofano, Adama, Garner, Lucie, Holcombe, Helen, Mepham, Sue, Mitchell, Alice Michael, Mwaura, Lucy, Praman, K., Vuylsteke, Alain, Zamikula, Julie, Bercades, Georgia, Brealey, David, Hass, Ingrid, Maccallum, Niall, Martir, Glady, Raith, Eamon, Reyes, Anna, Smyth, Deborah, Taylor, Abigail, Hughes, Rachel Anne, Thomas, Helen, Rees, Alun, Duskova, Michaela, Phipps, Janet, Brooks, Suzanne, Edwards, Michelle, Alexander, Peter, Allen, Schvearn, Bradley-Potts, Joanne, Brantwood, Craig, Egan, Jasmine, Felton, Timothy, Padden, Grace, Ward, Luke, Moss, Stuart, Glasgow, Susannah, Beesley, Kate, Board, Sarah, Kubisz-Pudelko, Agnieszka, Lewis, Alison, Perry, Je, Pippard, Lucy, Wood, Di, Buckley, Clare, Brown, Alison, Gregory, Jane, O’Connell, Susan, Smith, Tim, Belagodu, Zakaula, Fuller, Bridget, Gherman, Anca, Olufuwa, Olumide, Paramsothy, Remi, Stuart, Carmel, Oakley, Naomi, Kamundi, Charlotte, Tyl, David, Collins, Katy, Silva, Pedro, Taylor, June, King, Laura, Coates, Charlotte, Crowley, Maria, Wakefield, Phillipa, Beadle, Jane, Johnson, Laura, Sargeant, Janet, Anderson, Madeleine, Jardine, Catherine, Williams, Dewi, Parris, Victoria, Quaid, Sheena, Watson, Ekaterina, Melville, Julie, Naisbitt, Jay, Joseph, Rosane, Lazo, Maria, Walton, Olivia, Neal, Alan, Hill, Michaela, Kannan, Thogulava, Wild, Laura, Allan, Elizabeth, Darlington, Kate, Davies, Ffyon, Easton, Jack, Kumar, Sumit, Lean, Richard, Menzies, Daniel, Pugh, Richard, Qiu, Xinyi, Davies, Llino, Williams, Hannah, Scanlon, Jeremy, Davies, Gwyneth, Mackay, Callum, Lewis, Joannne, Rees, Stephanie, Coetzee, Samantha, Gales, Alistair, Raj, Meena, Sell, Craig, Langton, Helen, Watters, Malcolm, Novis, Catherine, Arbane, Gill, Bociek, Aneta, Campos, Sara, Grau, Neu, Jones, Tim Owen, Lim, Rosario, Marotti, Martina, Whitton, Christopher, Barron, Anthony, Collins, Ciara, Kaul, Sundeep, Passmore, Heather, Prendergast, Claire, Reed, Anna, Rogers, Paula, Shokkar, Rajvinder, Woodruff, Meriel, Middleton, Hayley, Polgar, Oliver, Nolan, Claire, Thwaites, Vicky, Mahay, Kanta, Sri-Chandana, Chunda, Scherewode, Joslan, Stephenson, Lorraine, Marsh, Sarah, Bancroft, Hollie, Bellamy, Mary, Carmody, Margaret, Daglish, Jacqueline, Moore, Faye, Rhodes, Joanne, Sangombe, Mirriam, Kadiri, Salma, Ayers, Amanda, Harrison, Wendy, North, Julie, Cavazza, Anna, Cockrell, Maeve, Corcoran, Eleanor, Depante, Maria, Finney, Clare, Jerome, Ellen, Mcphail, Mark, Nayak, Monalisa, Noble, Harriet, O’Reilly, Kevin, Pappa, Evita, Saha, Rohit, Saha, Sian, Smith, John, Knighton, Abigail, Gill, Mandy, Paul, Paul, Ratnam, Valli, Shelton, Sarah, Wynter, Inez, Baptista, David, Crowe, Rebecca, Fernandes, Rita, Herdman-Grant, Rosaleen, Joseph, Anna, Loveridge, Adam, Mckenley, India, Morino, Eriko, Naranjo, Andre, Simms, Richard, Sollesta, Kathryn, Swain, Andrew, Venkatesh, Harish, Khera, Jacyntha, Fox, Jonathan, Barber, Russell, Hewitt, Claire, Hilldrith, Annette, Jackson-Lawrence, Karen, Shepardson, Sarah, Wills, Maryanne, Butler, Susan, Tavares, Silvia, Cunningham, Amy, Hindale, Julia, Arif, Sarwat, George, Linsha, Twiss, Sophie, Wright, David, Holland, Maureen, Keenan, Natalie, Lyons, Marc, Wassall, Helen, Marsh, Chri, Mahenthran, Mervin, Carter, Emma, Kong, Thoma, Adanini, Oluronke, Bhatia, Nikhil, Msiska, Maine, Mew, Louise, Mwaura, Esther, Williams, Felicity, Wren, Lynn, Sutherland, Sara-Beth, Battle, Ceri, Brinkworth, Elaine, Harford, Rachel, Murphy, Carl, Newey, Luke, Rees, Tabitha, Williams, Marie, Arnold, Sophie, Hardy, John, Houlden, Henry, Moncur, Eleanor, Tariq, Ambreen, Tucci, Arianna, Convery, Karen, Fottrell-Gould, Deirdre, Hudig, Lisa, Keshet-Price, Jocelyn, Randell, Georgina, Stammers, Katie, Abdelrazik, Marwa, Bakthavatsalam, Dhanalakshmi, Elhassan, Munzir, Ganesan, Arunkumar, Haldeos, Anne, Moreno-Cuesta, Jeronimo, Purohit, Dharam, Vincent, Rachel, Xavier, Kugan, Rohit, Kumar, Alasdair, Frater, Saleem, Malik, David, Carter, Jenkins, Samuel, Lamond, Zoe, Wall, Alanna, Reynolds, Jessica, Campbell, Helen, Thompsom, Maria, Dodds, Steve, Duffy, Stacey, Butcher, Deborah, O’Sullivan, Susie, Butterworth-Cowin, Nicola, Deacon, Bethan, Hibbert, Meg, Pothecary, Carla, Tetla, Dariusz, Woodford, Christopher, Durga, Latha, Kennard-Holden, Gareth, de Gordoa, Laura Ortiz-Ruiz, Peasgood, Emily, Phillips, Claire, Skinner, Denise, Gaylard, Jane, Mullan, Dee, Newman, Julie, Davies, Ellie, Roche, Lisa, Sathe, Sonia, Brimfield, Lutece, Daly, Zoe, Pogson, David, Rose, Steve, Collins, Amy, Khaliq, Waqa, Gude, Estefania Treu, Allen, Louise, Beranova, Eva, Crisp, Nikki, Deery, Joanne, Hazelton, Tracy, Knight, Alicia, Price, Carly, Tilbey, Sorrell, Turki, Salah, Turney, Sharon, Giles, Julian, Booth, Simon, Bell, Gillian, English, Katy, Katary, Amro, Wilcox, Louise, Campbell, Rachael, Clarke, Noreen, Whiteside, Jonathan, Mascarenhas, Mairi, Donaldson, Avril, Matheson, Joanna, Barrett, Fiona, O’Hara, Marianne, O’Keefe, Laura, Bradley, Clare, Collier, Dawn, Walker, Rachel, Maynard, Victoria, Patel, Tahera, Smith, Matthew, Kazi, Aayesha, Hartley, Janice, Dykes, Joseph, Hijazi, Muhammad, Keith, Sarah, Khan, Meherunnisa, Ryan-Smith, Janet, Springle, Philippa, Thomas, Jacqueline, Truman, Nick, Saad, Samuel, Coleman, Dabheoc, Fine, Christopher, Matt, Roseanna, Gay, Bethan, Dalziel, Jack, Ali, Syamlan, Goodchild, Drew, Harling, Rhiannan, Bhatterjee, Ravi, Goddard, Wendy, Davison, Chloe, Duberly, Stephen, Hargreaves, Jeanette, Bolton, Rachel, Verlander, Mark, Williams, Alexandra, Blackman, Helen, Creagh-Brown, Ben, Donlon, Sinead, Michalak-Glinska, Natalia, Mtuwa, Sheila, Pristopan, Veronika, Salberg, Armorel, Smith, Eleanor, Stone, Sarah, Piercy, Charle, Verula, Jerik, Burda, Dorota, Montaser, Rugia, Harden, Lesley, Mayangao, Irving, Marriott, Cheryl, Bradley, Paul, Harris, Celia, Cooper, Joshua, Finch, Cheryl, Liderth, Sarah, Quinn, Alison, Waddington, Natalia, Fidler, Katy, Tagliavini, Emma, Donnelly, Kevin, Abel, Lynn, Brett, Michael, Digby, Brian, Gemmell, Lisa, Hornsby, Jame, Macgoey, Patrick, O’Neil, Pauline, Price, Richard, Rodden, Natalie, Rooney, Kevin, Sundaram, Radha, Thomson, Nicola, Flanagan, Rebecca, Hughes, Gareth, Latham, Scott, Mckenna, Emma, Anderson, Jennifer, Hull, Robert, Rhead, Kat, Branney, Debbie, Frankham, Jordan, Pitts, Sally, White, Nigel, Cristiano, Daniele, Dormand, Natalie, Farzad, Zohreh, Gummadi, Mahitha, Liyanage, Kamal, Patel, Brijesh V., Salmi, Sara, Sloane, Geraldine, Varghese, Mathew, Zborowski, Anelise C., Bean, Sarah, Burt, Karen, Spivey, Michael, Eastgate-Jackson, Christine, Filipe, Helder, Martin, Daniel, Maharajh, Amitaa, Garcia, Sara Mingo, De Neef, Mark, Lynch, Ceri, Howe, Gwenllian Sera, Singh, Jayaprakash, Turner, Keri, Ellis, Hannah, Stroud, Natalie, Cherian, Shiney, Cutler, Sean, Heron, Anne Emma, Roynon-Reed, Anna, Williams, Gemma, Richards, Owen, Cheema, Yusuf, Ahmad, Norfaizan, Barker, Joann, Bauchmuller, Kri, Bird, Sarah, Cawthron, Kay, Harrington, Kate, Jackson, Yvonne, Kibutu, Faith, Lenagh, Becky, Masuko, Shamiso, Raithatha, Ajay, Wiles, Matthew, Willson, Jayne, Newell, Helen, Lye, Alison, Nwafor, Lorenza, Jarman, Claire, Rowland-Jones, Sarah, Foote, David, Cole, Joby, Thompson, Roger, Watson, Jame, Hesseldon, Lisa, Macharia, Irene, Chetam, Luke, Smith, Jacqui, Ford, Amber, Anderson, Samantha, Birchall, Kathryn, Housley, Kay, Walker, Sara, Milner, Leanne, Hanratty, Helena, Trower, Helen, Phillips, Patrick, Oxspring, Simon, Donne, Ben, Bevan, Emily, Martin, Jane, Trodd, Dawn, Watson, Geoff, Brown, Caroline Wrey, Bunni, Lara, Jennings, Claire, Latif, Monica, Marshall, Rebecca, Subramanian, Gayathri, Bandla, Nageswar, Gellamucho, Minnie, Davies, Michelle, Thompson, Christopher, Trim, Fiona, Eapen, Beena, Ahmed, Cecilia, Baines, Balvinder, Clamp, Sarah, Colley, Julie, Haq, Risna, Hayes, Anne, Hulme, Jonathan, Hussain, Samia, Joseph, Sibet, Kumar, Rita, Maqsood, Zahira, Purewal, Manjit, Chandler, Ben, Elliott, Kerry, Mallinson, Janine, Turnbull, Alison, Dent, Kathy, Horsley, Elizabeth, Akhtar, Muhmmad Nauman, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Blakemore, Hayley, Borislavova, Borislava, Faulkner, Beverley, Gendall, Emma, Goff, Elizabeth, Hayes, Kati, Thomas, Matt, Worner, Ruth, Smith, Kerry, Stephens, Deanna, Delgado, Carlos Castro, Dawson, Deborah, Ding, Lijun, Durrant, Georgia, Ezeobu, Obiageri, Farnell-Ward, Sarah, Harrison, Abiola, Kanu, Rebecca, Leaver, Susannah, Maccacari, Elena, Manna, Soumendu, Saluzzio, Romina Peperman, Queiroz, Joana, Samakomva, Tinashe, Sicat, Christine, Texeira, Joana, Da Gloria, Edna Fernande, Lisboa, Ana, Rawlins, John, Mathew, Jisha, Kinch, Ashley, Hurt, William Jame, Shah, Nirav, Clark, Victoria, Thanasi, Maria, Yun, Nikki, Patel, Kamal, Crickmore, Vikki, Debreceni, Gabor, Wilkins, Joy, Nicol, Liz, Burn, Iona, Hambrook, Geraldine, Manso, Katarina, Penn, Ruth, Shanmugasundaram, Pradeep, Tebbutt, Julie, Thornton, Danielle, Rostron, Anthony, Roy, Alistair, Woods, Lindsey, Cornell, Sarah, Wakinshaw, Fiona, Rogerson, Kimberley, Jarmain, Jordan, Anderson, Peter, Archer, Katie, Austin, Karen, Davis, Caroline, Durie, Alison, Kelsall, Olivia, Thrush, Jessica, Vigurs, Charlie, Wood, Hannah-Louise, Tranter, Helen, Harrison, Alison, Cowley, Nichola, Mcalindon, Michael, Digby, Stephen, Low, Emma, Morgan, Aled, Cother, Naiara, Rankin, Tobia, Clayton, Sarah, Mccurdy, Alex, Allibone, Suzanne, Mary-Genetu, Roman, Patel, Amit, Mac, Ainhi, Murphy, Anthony, Mahjoob, Parisa, Nazari, Roonak, Worsley, Lucy, Fagan, Andrew, Mohamed Ali, Inthakab Ali, Beaumont, Karen, Blunt, Mark, Coton, Zoe, Curgenven, Hollie, Elsaadany, Mohamed, Fernandes, Kay, Ally, Sameena Mohamed, Rangarajan, Harini, Sarathy, Varun, Selvanayagam, Sivarupan, Vedage, Dave, White, Matthew, Fernandez-Roman, Jaime, Hamilton, David O., Johnson, Emily, Johnston, Brian, Martinez, Maria Lopez, Mulla, Suleman, Shaw, David, Waite, Alicia A. C., Waugh, Victoria, Welters, Ingeborg D., Williams, Karen, Bemand, Thoma, Black, Ethel, Rosa, Arnold Dela, Howle, Ryan, Jhanji, Shaman, Baikady, Ravishankar Rao, Tatham, Kate Colette, Thomas, Benjamin, Halkes, Matthew, Mercer, Pauline, Thornton, Lorraine, West, Joe, Baird, Tracy, Ruddy, Jim, Reece-Anthony, Rosie, Birt, Mark, Cowton, Amanda, Kay, Andrea, Kent, Melanie, Potts, Kathryn, Wilkinson, Ami, Naylor, Suzanne, Brown, Ellen, Clark, Michele, Purvis, Sarah, Cole, Jade, Davies, Rhy, Duffin, Donna, Hill, Helen, Player, Ben, Thomas, Emma, Williams, Angharad, Beith, Claire Marie, Black, Karen, Clements, Suzanne, Morrison, Alan, Strachan, Dominic, Taylor, Margaret, Clarkson, Michelle, D’Sylva, Stuart, Norman, Kathryn, Coventry, Tina, Fowler, Susan, Mcgregor, Amanda, Brady, Ailbhe, Chan, Rebekah, Mcivor, Shane, Prady, Helena, Whittle, Helen, Mathew, Bijoy, Clapham, Melanie, Harper, Rosemary, Poultney, Una, Rice, Polly, Mutch, Rachel, Baird, Yolanda, Butler, Aaron, Chadbourn, Indra, Folkes, Linda, Fox, Heather, Gardner, Amy, Gomez, Raquel, Hobden, Gillian, King, Kirsten, Margarson, Michael, Martindale, Tim, Meadows, Emma, Raynard, Dana, Thirlwall, Yvette, Helm, David, Margalef, Jordi, Greer, Sandra, Shuker, Karen, Smuts, Sara, Duffield, Joseph, Smith, Oliver, Mallon, Lewi, Claire, Watkin, Birkinshaw, Isobel, Carter, Joseph, Howard, Kate, Ingham, Joanne, Joy, Rosie, Pearson, Harriet, Roche, Samantha, Scott, Zoe, Knights, Ellen, Price, Alicia, Thomas, Alice, Thorpe, Chri, Abraheem, Azmerelda, Bamford, Peter, Cawley, Kathryn, Dunmore, Charlie, Faulkner, Maria, Girach, Rumanah, Jeffrey, Helen, Jones, Rhianna, London, Emily, Nagra, Imrun, Nasir, Farah, Sainsbury, Hannah, Smedley, Clare, Khade, Reena, Sundar, Ashok, Tsinaslanidis, George, Behan, Teresa, Burnett, Caroline, Hatton, Jonathan, Heeney, Elaine, Mitra, Atideb, Newton, Maria, Pollard, Rachel, Stead, Rachael, Birch, Jenny, Bough, Laura, Goodsell, Josie, Tutton, Rebecca, Williams, Patricia, Williams, Sarah, Winter-Goodwin, Barbara, Auld, Fiona, Donnachie, Joanne, Edmond, Ian, Prentice, Lynn, Runciman, Nikole, Salutous, Dario, Symon, Lesley, Todd, Anne, Turner, Patricia, Short, Abigail, Sweeney, Laura, Murdoch, Euan, Senaratne, Dhaneesha, Burns, Karen, Higham, Andrew, Anderson, Taya, Hawcutt, Dan, O’Malley, Laura, Rad, Laura, Rogers, Naomi, Saunderson, Paula, Allison, Kathryn Sian, Afolabi, Deborah, Whitbread, Jennifer, Jones, Dawn, Dore, Rachael, Lankester, Liana, Nikitas, Nikita, Wells, Colin, Stowe, Bethan, Spencer, Kayleigh, Cathcart, Susanne, Duffy, Katharine, Puxty, Alex, Puxty, Kathryn, Turner, Lynne, Ireland, Jane, Semple, Gary, Barry, Peter, Hilltout, Paula, Evitts, Jayne, Tyler, Amanda, Waldron, Joanne, Irvine, Val, Shelley, Benjamin, Akinkugbe, Olugbenga, Bamford, Alasdair, Beech, Emily, Belfield, Holly, Bell, Michael, Davies, Charlene, Jones, Gareth A. L., Mchugh, Tara, Meghari, Hamza, O’Neill, Lauran, Peters, Mark J., Ray, Samiran, Tomas, Ana Luisa, Gorman, Claire, Gupta, Abhinav, Timlick, Elizabeth, Brady, Rebecca, Bonner, Stephen, Hugill, Keith, Jones, Jessica, Liggett, Steven, Bashyal, Archana, Davidson, Neil, Hutton, Paula, Mckechnie, Stuart, Wilson, Jean, Flint, Neil, Rekha, Patel, Hales, Dawn, Cruz, Carina, Gopal, Shameer, Harris, Nichola, Lake, Victoria, Metherell, Stella, Radford, Elizabeth, Clement, Ian, Patel, Bijal, Gulati, A., Hays, Carole, Webster, K., Hudson, Anne, Webster, Andrea, Stephenson, Elaine, Mccormack, Louise, Slater, Victoria, Nixon, Rachel, Hanson, Helen, Fearby, Maggie, Kelly, Sinead, Bridgett, Victoria, Robinson, Philip, Almaden-Boyle, Christine, Austin, Pauline, Cabrelli, Louise, Cole, Stephen, Casey, Matt, Chapman, Susan, Whyte, Clare, Brayne, Adam, Fisher, Emma, Hunt, Jane, Jackson, Peter, Kaye, Duncan, Love, Nichola, Parkin, Juliet, Tuckey, Victoria, van Koutrik, Lynne, Carter, Sasha, Andrew, Benedict, Findlay, Louise, Adams, Katie, Bruce, Michelle, Connolly, Karen, Duncan, Tracy, T. -Michael, Helen, Lindergard, Gabriella, Hey, Samuel, Fox, Claire, Alfonso, Jordan, Durrans, Laura Jayne, Guerin, Jacinta, Hruska, Martin, Eltayeb, Ayaa, Lamb, Thoma, Hodgkiss, Tracey, Cooper, Lisa, Rothwell, Joanne, Dennis, Catherine, Mcgregor, Alastair, Srikaran, Sinduya, Sukha, Anisha, Davies, Kim, O’Brien, Linda, Omar, Zohra, Perkins, Emma, Lewis, Tracy, Sutherland, Isobel, Brooke, Hollie, Buckley, Sarah, Suarez, Jose Cebrian, Charlesworth, Ruth, Hansson, Karen, Norris, John, Poole, Alice, Rose, Alastair, Sandhu, Rajdeep, Sloan, Brendan, Smithson, Elizabeth, Thirumaran, Muthu, Wagstaff, Veronica, Metcalfe, Alexandra, Camsooksai, Julie, Humphrey, Charlotte, Jenkins, Sarah, Wadams, Beverley, Death, Yasmin, Adams, Colene, Agasou, Anita, Arden, Tracie, Bowes, Amy, Boyle, Pauline, Beekes, Mandy, Button, Heather, Capps, Nigel, Carnahan, Mandy, Carter, Anne, Childs, Danielle, Donaldson, Denise, Hard, Kelly, Hurford, Fran, Hussain, Yasmin, Javaid, Ayesha, Jones, Jame, Jose, Sanal, Leigh, Michael, Martin, Terry, Millward, Helen, Motherwell, Nichola, Rikunenko, Rachel, Stickley, Jo, Summers, Julie, Ting, Louise, Tivenan, Helen, Tonks, Louise, Wilcox, Rebecca, Bokhari, Maria, Lucas, Rachael, Mccormick, Wendy, Ritzema, Jenny, Sanderson, Amanda, Wild, Helen, Baxter, Nicola, Henderson, Steven, Kennedy-Hay, Sophie, Mcparland, Christopher, Rooney, Laura, Sim, Malcolm, Mccreath, Gordan, Brunton, Mark, Caterson, Je, Coles, Holly, Frise, Matthew, Rai, Sabi Gurung, Keating, Liza, Tilney, Emma, Bartley, Shauna, Bhuie, Parminder, Downes, Charlotte, Holding, Kathleen, Riches, Katie, Hilton, Mary, Hayman, Mel, Subramanian, Deepak, Daniel, Priya, Zitter, Letizia, Benyon, Sarah, Marriott, Suzie, Park, Linda, Keenan, Samantha, Gordon, Elizabeth, Quinn, Helen, Baines, Kizzy, Andrew, Gillian, Barclay, Lucy, Callaghan, Marie, Clark, Sarah, Hope, Dave, Marshall, Lucy, Mcculloch, Corrienne, Briton, Kate, Singleton, Jo, Birch, Sophie, Simpson, Kerry, Craig, Jayne, Demetriou, Carrie, Eckbad, Charlotte, Hierons, Sarah, Howie, Lucy, Mitchard, Sarah, Ramos, Lidia, Serrano-Ruiz, Alfredo, White, Katie, Kelly, Fiona, Amin, Vishal, Anastasescu, Elena, Anumakonda, Vikram, Karthik, Komala, Kausar, Rizwana, Reid, Karen, Smith, Jacqueline, Imeson-Wood, Janet, Bellini, Arianna, Bryant, Jade, Mayer, Anton, Pickard, Amy, Roe, Nichola, Sowter, Jason, Howlett, Alex, Criste, Kristine, Cusack, Rebecca, Golder, Kim, Golding, Hannah, Jones, Oliver, Leggett, Samantha, Male, Michelle, Marani, Martyna, Prager, Kirsty, Williams, Toran, Roberts, Belinda, Salmon, Karen, Gondo, Prisca, Hadebe, B., Kayani, Abdul, Masunda, Bridgett, Ahmed, Ashar, Morris, Anna, Jakkula, Sriniva, Long, Kate, Whiteley, Simon, Wilby, Elizabeth, Ogg, Bethan, Moultrie, Sam, Odam, M., Bewley, Jeremy, Garland, Zoe, Grimmer, Lisa, Gumbrill, Bethany, Johnson, Rebekah, Sweet, Katie, Webster, Denise, Efford, Georgia, Bennett, Sara, Goodwin, Emma, Jackson, Matthew, Kent, Alissa, Tibke, Clare, Woodyatt, Wiesia, Zaki, Ahmed, Daniel, Amelia, Finn, Joanne, Saha, Rajnish, Bremmer, Pamela, Allan, J., Geary, T., Houston, Gordon, Meikle, A., O’Brien, P., Bell, Dina, Boyle, Rosalind, Douglas, Katie, Glass, Lynn, Lee, Emma, Lennon, Liz, Rattray, Austin, Charnock, Rob, Mcfarland, Denise, Cosgrove, Denise, Attwood, Ben, Parsons, Penny, Carmody, Siobhain, Oblak, Metod, Popescu, Monica, Thankachen, Mini, Baruah, Rosie, Morris, Sheila, Ferguson, Susie, Shepherd, Amy, Altabaibeh, Abdelhakim, Alvaro, Ana, Gilbert, Kayleigh, Ma, Louise, Mostoles, Loreta, Parmar, Chetan, Simpson, Kathryn, Jetha, Champa, Booker, Lauren, Pratley, Anezka, Cosier, Tracey, Millen, Gemma, Schumacher, Natasha, Weston, Heather, Rand, Jame, Alex, Beatrice, Bach, Benjamin, Barclay, Wendy S., Bogaert, Debby, Chand, Meera, Cooke, Graham S., Docherty, Annemarie B., Dunning, Jake, da Silva Filipe, Ana, Fletcher, Tom, Green, Christoper A., Harrison, Ewen M., Hiscox, Julian A., Ijaz, Samreen, Khoo, Saye, Lim, Wei Shen, Mentzer, Alexander J., Merson, Laura, Noursadeghi, Mahdad, Moore, Shona C., Palmarini, Massimo, Paxton, William A., Pollakis, Georgio, Price, Nichola, Rambaut, Andrew, Robertson, David L., Sancho-Shimizu, Vanessa, Scott, Janet T., de Silva, Thushan, Sigfrid, Louise, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Tedder, Richard S., Thomson, Emma C., Roger Thompson, A. A., Thwaites, Ryan S., Turtle, Lance C. W., Gupta, Rishi K., Palmieri, Carlo, Swann, Olivia V., Zambon, Maria, Dumas, Marc-Emmanuel, Griffin, Julian L., Takats, Zoltan, Chechi, Kanta, Andrikopoulos, Petro, Osagie, Anthonia, Olanipekun, Michael, Liggi, Sonia, Lewis, Matthew R., Correia, Gonçalo dos Santo, Sands, Caroline J., Takis, Panteleimon, Maslen, Lynn, Greenhalf, William, Shaw, Victoria, Mcdonald, Sarah E., Keating, Seán, Ahmed, Katie A., Armstrong, Jane A., Ashworth, Milton, Asiimwe, Innocent G., Bakshi, Siddharth, Barlow, Samantha L., Booth, Laura, Brennan, Benjamin, Bullock, Katie, Catterall, Benjamin W. A., Clark, Jordan J., Clarke, Emily A., Cooper, Louise, Cox, Helen, Davis, Christopher, Dincarslan, Oslem, Dunn, Chri, Dyer, Philip, Elliott, Angela, Evans, Anthony, Finch, Lorna, Fisher, Lewis W. S., Foster, Terry, Garcia-Dorival, Isabel, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L., Jones, Christopher B., Jones, Trevor R., Khandaker, Shadia, King, Katharine, Kiy, Robyn T., Koukorava, Chrysa, Lake, Annette, Lant, Suzannah, Latawiec, Diane, Lavelle-Langham, Lara, Lefteri, Daniella, Lett, Lauren, Livoti, Lucia A., Mancini, Maria, Mcdonald, Sarah, Mcevoy, Laurence, Mclauchlan, John, Metelmann, Soeren, Miah, Nahida S., Middleton, Joanna, Mitchell, Joyce, Murphy, Ellen G., Penrice-Randal, Rebekah, Pilgrim, Jack, Prince, Tessa, Reynolds, Will, Ridley, P. Matthew, Sales, Debby, Shaw, Victoria E., Shears, Rebecca K., Small, Benjamin, Subramaniam, Krishanthi S., Szemiel, Agnieska, Taggart, Aislynn, Tanianis-Hughes, Jolanta, Thomas, Jordan, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Zhang, J. Eunice, Flaherty, Lisa, Maziere, Nicole, Cass, Emily, Carracedo, Alejandra Doce, Carlucci, Nicola, Holmes, Anthony, Massey, Hannah, Murphy, Lee, Wrobel, Nicola, Mccafferty, Sarah, Morrice, Kirstie, Maclean, Alan, Armstrong, Ruth, Boz, Ceilia, Brown, Adam, Coutts, Audrey, Cullum, Louise, Day, Nicky, Donnelly, Lorna, Duncan, Esther, Fawkes, Angie, Finernan, Paul, Gilchrist, Tammy, Golightly, Ailsa, Hafezi, Katarzyna, Law, Dawn, Law, Rachel, Law, Sarah, Macgillivray, Louise, Mal, Hanning, Mcmaster, Ellie, Meikle, Jen, Oosthuyzen, Wilna, Paterson, Trevor, Stenhouse, Andrew, Swets, Maaike, Szoor-McElhinney, Helen, Taneski, Filip, Wackett, Tony, Ward, Mairi, Weaver, Jane, Coyle, Judy, Gallagher, Bernadette, Lidstone-Scott, Rebecca, Hamilton, Debbie, Schon, Katherine, Furlong, Anita, Biggs, Heather, Griffiths, Fiona, Andrews, Eleanor, Brickell, Kathy, Smyth, Michelle, Murphy, Lorna, Carson, Gail, Hardwick, Hayley, Donohue, Chloe, Pérez-Tur, Jordi [0000-0002-9111-1712], Martín, Javier [0000-0002-2202-0622], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Massachusetts General Hospital [Boston], A list of authors and their affiliations appears in the Supplementary Information, Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, ANR-20-CO11-0001,AABIFNCOV,Bases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19.(2020), ANR-20-COVI-0003,GENCOVID,Identification des défauts monogéniques de l'immunité responsables des formes sévères de COVID-19 chez les patients précédemment en bonne santé(2020), ANR-21-COVR-0039,GenMIS-C,Recherche des Déficits immunitaires innées monogéniques prédisposant au syndrome inflammatoire multisystémique chez l'enfant.(2021), UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (MGD) Service de gastro-entérologie, Niemi, M, Karjalainen, J, Liao, R, Neale, B, Daly, M, Ganna, A, Pathak, G, Andrews, S, Kanai, M, Veerapen, K, Fernandez-Cadenas, I, Schulte, E, Striano, P, Marttila, M, Minica, C, Marouli, E, Karim, M, Wendt, F, Savage, J, Sloofman, L, Butler-Laporte, G, Kim, H, Kanoni, S, Okada, Y, Byun, J, Han, Y, Uddin, M, Smith, G, Willer, C, Buxbaum, J, Mehtonen, J, Finucane, H, Cordioli, M, Martin, A, Zhou, W, Pasaniuc, B, Julienne, H, Aschard, H, Shi, H, Yengo, L, Polimanti, R, Ghoussaini, M, Schwartzentruber, J, Dunham, I, Chwialkowska, K, Francescatto, M, Trankiem, A, Balaconis, M, Davis, L, Lee, S, Priest, J, Renieri, A, Sankaran, V, van Heel, D, Deelen, P, Richards, J, Nakanishi, T, Biesecker, L, Kerchberger, V, Baillie, J, Mari, F, Bernasconi, A, Baillie, S, Canakoglu, A, Wolford, B, Faucon, A, Dutta, A, Schurmann, C, Harry, E, Birney, E, Nguyen, H, Nasir, J, Kaunisto, M, Solomonson, M, Dueker, N, Vadgama, N, Limou, S, Rahmouni, S, Mbarek, H, Darwish, D, Albertos, R, Pérez-Tur, J, Li, R, Folkersen, L, Moltke, I, Koelling, N, Teumer, A, Kousathanas, A, Utrilla, A, Verdugo, R, Zárate, R, Medina-Gómez, C, Gómez-Cabrero, D, Carnero-Montoro, E, Cadilla, C, Moreno-Estrada, A, Garmendia, A, Moya, L, Sedaghati-Khayat, B, Boua, P, Favé, M, Francioli, L, Lemaçon, A, Migeotte, I, Patel, S, Varnai, R, Szentpeteri, J, Sipeky, C, Colombo, F, von Hohenstaufen, K, Lio, P, Vallerga, C, Wang, Q, Tanigawa, Y, Im, H, Han, C, Song, H, Lim, J, Lee, Y, Kim, S, Im, S, Atanasovska, B, Ahmad, H, Boer, C, Jansen, P, Franke, L, Kaja, E, Pasko, D, Kennis-Szilagyi, I, Kornilov, S, Prijatelj, V, Prokić, I, Sivanadhan, I, Perumal, S, Esmaeeli, S, Pearson, N, Auton, A, Shelton, J, Shastri, A, Filshtein-Sonmez, T, Coker, D, Symons, A, Esparza-Gordillo, J, Aslibekyan, S, O’Connell, J, Ye, C, Weldon, C, Perera, M, O’Leary, K, Tuck, M, O’Brien, T, Meltzer, D, O’Donnell, P, Nutescu, E, Yang, G, Alarcon, C, Herrmann, S, Mazurek, S, Banagan, J, Hamidi, Z, Barbour, A, Raffat, N, Moreno, D, Friedman, P, Ferwerda, B, van de Beek, D, Brouwer, M, Vlaar, A, Wiersinga, W, Posthuma, D, Tissink, E, Koos Zwinderman, A, Uffelmann, E, van Agtmael, M, Algera, A, van Baarle, F, Bax, D, Beudel, M, Jan Bogaard, H, Bomers, M, Bonta, P, Bos, L, Botta, M, de Brabander, J, de Bree, G, de Bruin, S, Bugiani, M, Bulle, E, Chouchane, O, Cloherty, A, Dongelmans, D, Elbers, P, Fleuren, L, Geerlings, S, Geerts, B, Geijtenbeek, T, Girbes, A, Goorhuis, B, Grobusch, M, Hafkamp, F, Hagens, L, Hamann, J, Harris, V, Hemke, R, Hermans, S, Heunks, L, Hollmann, M, Horn, J, Hovius, J, de Jong, M, Koning, R, van Mourik, N, Nellen, J, Nossent, E, Paulus, F, Peters, E, van der Poll, T, Preckel, B, Prins, J, Raasveld, J, Reijnders, T, Schinkel, M, Schultz, M, Schuurman, A, Sigaloff, K, Smit, M, Stijnis, C, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A, van der Valk, M, Veelo, D, de Vries, H, van Vugt, M, Wouters, D, Minnaar, R, Kromhout, A, van Uffelen, K, Wolterman, R, Roberts, G, Park, D, Ball, C, Coignet, M, Mccurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, E, Rand, K, Girshick, A, Guturu, H, Baltzell, A, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Bouysran, Y, Busson, A, Peyrassol, X, Wilkin, F, Pichon, B, Smits, G, Vandernoot, I, Goffard, J, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Jadot, L, Azarzar, S, Dellot, P, Gofflot, S, Claassen, S, Bertrand, A, Parzibut, G, Clarinval, M, Moermans, C, Malaise, O, El Kandoussi, K, Thonon, R, Huynen, P, Mesdagh, A, Melo, S, Jacques, N, Di Valentin, E, Giroule, F, Collignon, A, Radermecker, C, Lebrun, M, Perée, H, Latour, S, Barada, O, Sanchez, J, Josse, C, Boujemla, B, Meunier, M, Mariavelle, E, Anania, S, Gazon, H, Juszczak, D, Fadeur, M, Camby, S, Meuris, C, Thys, M, Jacques, J, Henket, M, Léonard, P, Frippiat, F, Giot, J, Sauvage, A, Von Frenckell, C, Mni, M, Wéry, M, Staderoli, A, Belhaj, Y, Lambermont, B, Morrison, D, Mooser, V, Forgetta, V, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, D, Lathrop, G, Adra, D, Cox, N, Below, J, Sealock, J, Shuey, M, Polikowsky, H, Petty, L, Shaw, D, Chen, H, Zhu, W, Ludwig, K, Schröder, J, Maj, C, Rolker, S, Nöthen, M, Fazaal, J, Keitel, V, Jensen, B, Feldt, T, Kurth, I, Marx, N, Dreher, M, Pink, I, Cornberg, M, Illig, T, Lehmann, C, Schommers, P, Augustin, M, Rybniker, J, Knopp, L, Eggermann, T, Volland, S, Altmüller, J, Berger, M, Brenner, T, Hinney, A, Witzke, O, Bals, R, Herr, C, Ludwig, N, Walter, J, Fuchsberger, C, Pattaro, C, De Grandi, A, Pramstaller, P, Emmert, D, Melotti, R, Foco, L, Mascalzoni, D, Gögele, M, Domingues, F, Hicks, A, Gignoux, C, Wicks, S, Crooks, K, Barnes, K, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Goldstein, D, Kiryluk, K, Sengupta, S, Chung, W, Reilly, M, Khan, A, Wang, C, Povysil, G, Bhardwaj, N, Gharavi, A, Ionita-Laza, I, Shang, N, O’Byrne, S, Nandakumar, R, Menon, A, So, Y, Hod, E, Pendrick, D, Park, S, Kang, C, Lee, H, Song, K, Jae Yoon, K, Paik, N, Seok, W, Yoon, H, Joo, E, Chang, Y, Ryu, S, Park, W, Su Park, J, Un Park, K, Ham, S, Jung, J, Kim, E, Ellinghaus, D, Degenhardt, F, Cáceres, M, Juzenas, S, Lenz, T, Albillos, A, Julià, A, Heidecker, B, Garcia, F, Kurth, F, Tran, F, Hanses, F, Zoller, H, Holter, J, Fernández, J, Sander, L, Rosenstiel, P, Koehler, P, de Cid, R, Asselta, R, Schreiber, S, Hehr, U, Prati, D, Baselli, G, Valenti, L, Bujanda, L, Banales, J, Duga, S, D’Amato, M, Romero-Gómez, M, Buti, M, Invernizzi, P, Franke, A, Hov, J, Karlsen, T, Folseraas, T, Maya-Miles, D, Teles, A, Azuure, C, Wacker, E, Uellendahl-Werth, F, Elabd, H, Arora, J, Lerga-Jaso, J, Wienbrandt, L, Rühlemann, M, Wendorff, M, Vadla, M, Lenning, O, Özer, O, Myhre, R, Raychaudhuri, S, Tanck, A, Gassner, C, Hemmrich-Stanisak, G, Kässens, J, Figuera Basso, M, Schulzky, M, Wittig, M, Braun, N, Wesse, T, Albrecht, W, Yi, X, Ortiz, A, Chercoles, A, Ruiz, A, Mantovani, A, Holten, A, Mayer, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Barreira, A, Lleo, A, Kildal, A, Glück, A, Nolla, A, Latiano, A, Dyrhol-Riise, A, Muscatello, A, Voza, A, Rando-Segura, A, Solier, A, Karina, B, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Bellinghausen, C, Ferrando, C, Quereda, C, Skurk, C, Thibeault, C, Spinner, C, Lange, C, Hu, C, Cappadona, C, Bianco, C, Sancho, C, Lihaug Hoff, D, Galimberti, D, Jiménez, D, Pestaña, D, Toapanta, D, Azzolini, E, Scarpini, E, Helbig, E, Urrechaga, E, Paraboschi, E, Pontali, E, Reverter, E, Navas, E, Arana, E, Sánchez, F, Ceriotti, F, Malvestiti, F, Mesonero, F, Pezzoli, G, Lamorte, G, Neb, H, My, I, Hernández, I, de Rojas, I, Galván-Femenia, I, Heyckendorf, J, Badia, J, Schneider, J, Goikoetxea, J, Kraft, J, Müller, K, Gaede, K, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Izquierdo-Sanchez, L, Sumoy, L, Lippert, L, Terranova, L, Garbarino, L, Téllez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Gutiérrez-Stampa, M, Vehreschild, M, Marquié, M, Castoldi, M, Cecconi, M, Boada, M, Seilmaier, M, Mazzocco, M, Rodríguez-Gandía, M, Ayo, N, Blay, N, Martínez, N, Cornely, O, Palmieri, O, Tentorio, P, Rodrigues, P, España, P, Hoffmann, P, Bacher, P, Suwalski, P, de Pablo, R, Nieto, R, Badalamenti, S, Ciesek, S, Bombace, S, Wilfling, S, Brunak, S, Heilmann-Heimbach, S, Ripke, S, Bahmer, T, Landmesser, U, Protzer, U, Rimoldi, V, Skogen, V, Andrade, V, Moreno, V, Poller, W, Farre, X, Wang, X, Khodamoradi, Y, Karadeniz, Z, de Salazar, A, Palom, A, Garcia-Fernandez, A, Blanco-Grau, A, Zanella, A, Bandera, A, Nebel, A, Biondi, A, Caballero-Garralda, A, Gori, A, Lind, A, Fracanzani, A, Peschuck, A, Pesenti, A, de la Horra, C, Milani, C, Paccapelo, C, Angelini, C, Cea, C, Muñiz-Diaz, E, Sandoval, E, Calderón, E, Solligård, E, Aziz, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Medrano, F, Rodriguez-Frias, F, Müller, F, Grasselli, G, Costantino, G, Cardamone, G, Foti, G, Matullo, G, Kurihara, H, Afset, J, Damås, J, Ampuero, J, Martín, J, Erdmann, J, Bergan, J, Goerg, S, Ferrusquía-Acosta, J, Quero, J, Delgado, J, Guerrero, J, Risnes, K, Bettini, L, Moreira, L, Gustad, L, Santoro, L, Scudeller, L, Riveiro-Barciela, M, Schaefer, M, Carrabba, M, Valsecchi, M, Hernandez-Tejero, M, Acosta-Herrera, M, D’Angiò, M, Baldini, M, Cazzaniga, M, Ciccarelli, M, Bocciolone, M, Miozzo, M, Chueca, N, Montano, N, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Castro, P, Ferrer, R, Gualtierotti, R, Gallego-Durán, R, Morilla, R, Haider, S, Marsal, S, Aneli, S, Pelusi, S, Bosari, S, Aliberti, S, Dudman, S, Zheng, T, Pumarola, T, Cejudo, T, Monzani, V, Friaza, V, Peter, W, Dopazo, X, May, S, Grimsrud, M, Gudbjartsson, D, Stefansson, K, Sulem, P, Sveinbjornsson, G, Melsted, P, Norddahl, G, Swerford Moore, K, Thorsteinsdottir, U, Holm, H, Alarcón-Riquelme, M, Bernardo, D, Martínez-Bueno, M, Rello, S, Magi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Palotie, A, Rivolta, C, Bochud, P, Bibert, S, Boillat, N, Nussle, S, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, J, Oddo, M, zu Bentrup, F, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, R, Lannepoudenx, Y, Portopena, L, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, E, Manuel, O, Munting, A, Papadimitriou-Olivgeris, M, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hügli, O, Meuwly, J, Pantet, O, Bochud, M, D’Acremont, V, Younes, S, Cerny, A, O’Mahony, L, von Mering, C, Frischknecht, M, Kleger, G, Filipovic, M, Kahlert, C, Wozniak, H, Negro, T, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, Carreras, A, Galván-Femenía, I, Farré, X, Cortés, B, Mercader, J, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castaño-Vinyals, G, Dobaño, C, Gori, M, Mondelli, M, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, M, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, G, Spagnesi, M, Canaccini, A, Ognibene, A, D’Arminio Monforte, A, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, P, Panese, S, Scaggiante, R, Monica, M, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Di Biagio, A, Masucci, L, Valente, S, Mandalà, M, Zucchi, P, Giannattasio, F, Coviello, D, Mussini, C, Bosio, G, Tavecchia, L, Crotti, L, Rizzi, M, La Rovere, M, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Di Pietro, M, Sabrina, R, Luchi, S, Barbieri, C, Acquilini, D, Andreucci, E, Paciosi, F, Segala, F, Tiseo, G, Falcone, M, Lista, M, Poscente, M, De Vivo, O, Petrocelli, P, Guarnaccia, A, Baroni, S, Perticaroli, V, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Ceri, S, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Bergomi, M, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, M, Lo Rizzo, C, Pinto, A, Beligni, G, Tommasi, A, Di Sarno, L, Palmieri, M, Carriero, M, Alaverdian, D, Iuso, N, Inchingolo, G, Busani, S, Bruno, R, Vecchia, M, Belli, M, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, M, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Zanelli, G, Bergantini, L, D’Alessandro, M, Cameli, P, Bennet, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazi, A, Lorubbio, M, Merlini, E, Miraglia, F, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Andretta, F, Gatti, F, Parisi, S, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, G, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Bottà, G, Di Domenico, P, Rancan, I, Bianchi, F, Colombo, R, Hunt, K, Trembath, R, Huang, Q, Martin, H, Mason, D, Trivedi, B, Wright, J, Finer, S, Griffiths, C, Akhtar, S, Anwar, M, Arciero, E, Ashraf, S, Breen, G, Chung, R, Curtis, C, Chowdhury, M, Colligan, G, Deloukas, P, Durham, C, Hurles, M, Hussain, S, Islam, K, Lavery, C, Lerner, R, Macarthur, D, Maclaughlin, B, Miah, S, Newman, B, Safa, N, Tahmasebi, F, Smith, A, Boughton, A, Li, K, Lefaive, J, Annis, A, Jannes, C, Krieger, J, Pereira, A, Velho, M, Marques, E, Lima, I, Tada, M, Valino, K, Mccarthy, M, Rosenberger, C, Lee, J, Chang, D, Hammer, C, Hunkapiller, J, Mahajan, A, Pendergrass, S, Sucheston-Campbell, L, Yaspan, B, Shin, E, Jang, H, Kym, S, Kim, Y, Jeong, H, Kwon, K, Kim, J, Jang, Y, Choe, K, Kang, Y, Jee, S, Jung, K, Parikh, V, Ashley, E, Wheeler, M, Rivas, M, Bustamante, C, Pinksy, B, Febbo, P, Farh, K, Schroth, G, Desouza, F, Dalton, K, Christle, J, Deboever, C, Szalma, S, Rubinacci, S, Delaneau, O, Gorzynski, J, de Jong, H, Sutton, S, Youlton, N, Joshi, R, Jimenez-Morales, D, Hughes, C, Amar, D, Ioannidis, A, Hershman, S, Kirillova, A, Seo, K, Huang, Y, Shoura, M, Hammond, N, Watson, N, Raja, A, Huang, C, Sahoo, M, Wang, H, Zhen, J, Rakitko, A, Ilinsky, V, Yermakovich, D, Popov, I, Chernitsov, A, Kovalenko, E, Krasnenko, A, Plotnikov, N, Stetsenko, I, Kim, A, Cirulli, E, Schiabor Barrett, K, Bolze, A, White, S, Washington, N, Lu, J, Riffle, S, Tanudjaja, F, Ramirez, J, Leonetti, N, Neveux, I, Dabe, S, Grzymski, J, Esteban Miñano, J, Aguirre, L, López-Collazo, E, de la Mata Pazos, M, Cerrato, L, Lozano-Rodríguez, R, Avendaño-Ortiz, J, Arcos, V, Montalbán-Hernández, K, Quiroga, J, Pascual-Iglesias, A, Maroun-Eid, C, Martín-Quirós, A, Namkoong, H, Imoto, S, Katayama, K, Fukunaga, K, Kitagawa, Y, Sato, T, Hasegawa, N, Kumanogoh, A, Kimura, A, Ai, M, Tokunaga, K, Kanai, T, Miyano, S, Ogawa, S, Edahiro, R, Sonehara, K, Shirai, Y, Ishii, M, Kabata, H, Masaki, K, Kamata, H, Ikemura, S, Chubachi, S, Okamori, S, Terai, H, Tanaka, H, Morita, A, Asakura, T, Sasaki, J, Morisaki, H, Uwamino, Y, Nanki, K, Mikami, Y, Tomono, K, Kato, K, Matsuda, F, Takahashi, M, Hizawa, N, Takeda, Y, Hirata, H, Shiroyama, T, Miyawaki, S, Suzuki, K, Maeda, Y, Nii, T, Noda, Y, Niitsu, T, Adachi, Y, Enomoto, T, Amiya, S, Hara, R, Takahashi, K, Anzai, T, Hasegawa, T, Ito, S, Koike, R, Endo, A, Uchimura, Y, Miyazaki, Y, Honda, T, Tateishi, T, Tohda, S, Ichimura, N, Sonobe, K, Sassa, C, Nakajima, J, Nannya, Y, Omae, Y, Harada, N, Hiki, M, Takagi, H, Nakamura, A, Tagaya, E, Kawana, M, Arimura, K, Ishiguro, T, Takayanagi, N, Isono, T, Takaku, Y, Takano, K, Anan, R, Nakajima, Y, Nakano, Y, Nishio, K, Ueda, S, Hayashi, R, Tateno, H, Hase, I, Yoshida, S, Suzuki, S, Mitamura, K, Saito, F, Ueda, T, Azuma, M, Nagasaki, T, Yasui, Y, Hasegawa, Y, Mutoh, Y, Yoshiyama, T, Shoko, T, Kojima, M, Adachi, T, Ishikawa, M, Watanabe, K, Manabe, T, Ito, F, Fukui, T, Funatsu, Y, Koh, H, Hirai, Y, Kawashima, H, Narita, A, Niwa, K, Sekikawa, Y, Yoshiya, K, Yoshihara, T, Suzuki, Y, Nakayama, S, Masuzawa, K, Nishi, K, Nishitsuji, M, Tani, M, Inoue, T, Hirano, T, Kobayashi, K, Miyazawa, N, Kimura, Y, Sado, R, Ogura, T, Kitamura, H, Murohashi, K, Nakachi, I, Baba, R, Arai, D, Fuke, S, Saito, H, Kuwahara, N, Fujiwara, A, Okada, T, Baba, T, Noda, J, Mashimo, S, Yagi, K, Shiomi, T, Hashiguchi, M, Odani, T, Mochimaru, T, Oyamada, Y, Mori, N, Izumi, N, Nagata, K, Taki, R, Murakami, K, Yamada, M, Sugiura, H, Hayashi, K, Shimizu, T, Gon, Y, Fujitani, S, Tsuchida, T, Yoshida, T, Kagaya, T, Kita, T, Sakagami, S, Kimizuka, Y, Kawana, A, Nakamura, Y, Ishikura, H, Takata, T, Kikuchi, T, Taniyama, D, Nakamura, M, Kodama, N, Kaneyama, Y, Maeda, S, Nagasaki, Y, Okamoto, M, Ishihara, S, Ito, A, Chihara, Y, Takeuchi, M, Onoi, K, Hashimoto, N, Wakahara, K, Ando, A, Masuda, M, Wakabayashi, A, Watanabe, H, Sageshima, H, Nakada, T, Abe, R, Shimada, T, Kawamura, K, Ichikado, K, Nishiyama, K, Yamasaki, M, Hashimoto, S, Kusaka, Y, Ohba, T, Isogai, S, Takada, M, Kanda, H, Komase, Y, Sano, F, Asano, K, Oguma, T, Harada, M, Takahashi, T, Shibusawa, T, Abe, S, Kono, Y, Togashi, Y, Izumo, T, Inomata, M, Awano, N, Ogata, T, Kanehiro, A, Ozaki, S, Fuchimoto, Y, Ogura, S, Yoshida, K, Beppu, S, Fukuyama, S, Eriguchi, Y, Yonekawa, A, Inoue, Y, Yamagata, K, Chiba, S, Narumoto, O, Nagai, H, Ooshima, N, Motegi, M, Sagara, H, Tanaka, A, Ohta, S, Shibata, Y, Tanino, Y, Sato, Y, Yamada, Y, Hashino, T, Shinoki, M, Iwagoe, H, Imamura, T, Umeda, A, Shimada, H, Endo, M, Hayashi, S, Nakano, S, Yatomi, M, Maeno, T, Ishii, T, Utsugi, M, Ono, A, Kanaoka, K, Ihara, S, Komuta, K, Boezen, M, Claringbould, A, Lopera, E, Warmerdam, R, Vonk, J, van Blokland, I, Lanting, P, Ori, A, Obeidat, M, Hernández Cordero, A, Sin, D, Bossé, Y, Joubert, P, Hao, K, Nickle, D, Timens, W, van den Berge, M, Feng, Y, Weiss, S, Karlson, E, Smoller, J, Murphy, S, Meigs, J, Woolley, A, Green, R, Perez, E, Zöllner, S, Wang, J, Beck, A, Ascolillo, S, Sebra, R, Collins, B, Levy, T, Sealfon, S, Jordan, D, Thompson, R, Gettler, K, Chaudhary, K, Belbin, G, Preuss, M, Hoggart, C, Choi, S, Underwood, S, Salib, I, Britvan, B, Keller, K, Tang, L, Peruggia, M, Hiester, L, Niblo, K, Aksentijevich, A, Labkowsky, A, Karp, A, Zlatopolsky, M, Zyndorf, M, Charney, A, Beckmann, N, Schadt, E, Abul-Husn, N, Cho, J, Itan, Y, Kenny, E, Loos, R, Nadkarni, G, Do, R, O’Reilly, P, Huckins, L, Ferreira, M, Abecasis, G, Leader, J, Cantor, M, Justice, A, Carey, D, Chittoor, G, Josyula, N, Kosmicki, J, Horowitz, J, Baras, A, Gass, M, Yadav, A, Mirshahi, T, Jan Hottenga, J, Bartels, M, de Geus, E, Nivard, M, Verma, A, Ritchie, M, Rader, D, Li, B, Verma, S, Lucas, A, Bradford, Y, Zara, F, Salpietro, V, Scala, M, Iacomino, M, Scudieri, P, Bocciardi, R, Minetti, C, Vari, M, Rahier, J, Giorgio, E, Carli, D, Louis, E, Bulik, C, Landén, M, Brusco, A, Ferrero, G, Madia, F, Fundín, B, Ismail, S, Saad, C, Al-Sarraj, Y, Badji, R, Al-Muftah, W, Al Thani, A, Afifi, N, Klovins, J, Rovite, V, Rescenko, R, Peculis, R, Ustinova, M, Zeberg, H, Frithiof, R, Hultström, M, Lipcsey, M, Johnson, R, Geschwind, D, Freimer, N, Butte, M, Ding, Y, Chiu, A, Chang, T, Boutros, P, Moutsianas, L, Caulfield, M, Scott, R, Walker, S, Stuckey, A, Odhams, C, Rhodes, D, Fowler, T, Rendon, A, Chan, G, Arumugam, P, Karczewski, K, Wilson, D, Spencer, C, Crook, D, Wyllie, D, O’Connell, A, Atkinson, E, Tsuo, K, Baya, N, Turley, P, Gupta, R, Walters, R, Palmer, D, Sarma, G, Cheng, N, Lu, W, Churchhouse, C, Goldstein, J, King, D, Seed, C, Bryant, S, Satterstrom, F, Band, G, Earle, S, Lin, S, Arning, N, Armstrong, J, Rudkin, J, Callier, S, Cusick, C, Soranzo, N, Zhao, J, Danesh, J, Di Angelantonio, E, Butterworth, A, Sun, Y, Huffman, J, Cho, K, O’Donnell, C, Tsao, P, Gaziano, J, Peloso, G, Ho, Y, Mian, M, Scaggiante, F, Chang, X, Glessner, J, Hakonarson, H, Mcguigan, P, Prockter Moore, L, Vizcaychipi, M, Hall, K, Campbell, A, Nichol, A, Ward, G, Page, V, Semple, M, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Aldera, E, Alegria, A, Angus, B, Ashish, A, Atkinson, D, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Basude, S, Baxter, D, Beadsworth, M, Bernatoniene, J, Berridge, J, Best, N, Bothma, P, Chadwick, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Child, J, Chukkambotla, S, Clark, T, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M, Dark, P, Dawson, C, Dervisevic, S, Donnison, P, Douthwaite, S, Drummond, A, Durand, I, Dushianthan, A, Dyer, T, Evans, C, Eziefula, C, Fegan, C, Finn, A, Fullerton, D, Garg, S, Garg, A, Gkrania-Klotsas, E, Godden, J, Goldsmith, A, Graham, C, Hardy, E, Hartshorn, S, Harvey, D, Havalda, P, Hawcutt, D, Hobrok, M, Hodgson, L, Hormis, A, Jacobs, M, Jain, S, Jennings, P, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kendall, J, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Laha, S, Laird, S, Larkin, S, Leiner, T, Lillie, P, Limb, J, Linnett, V, Little, J, Lyttle, M, Macmahon, M, Macnaughton, E, Mankregod, R, Masson, H, Matovu, E, Mccullough, K, Mcewen, R, Meda, M, Mills, G, Minton, J, Ward, K, Mirfenderesky, M, Mohandas, K, Mok, Q, Moon, J, Moore, E, Morgan, P, Morris, C, Mortimore, K, Moses, S, Mpenge, M, Mulla, R, Murphy, M, Nagel, M, Nagarajan, T, Nelson, M, O’Shea, M, Otahal, I, Ostermann, M, Pais, M, Panchatsharam, S, Papakonstantinou, D, Paraiso, H, Patel, B, Pattison, N, Pepperell, J, Peters, M, Phull, M, Pintus, S, Pooni, J, Post, F, Price, D, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Roberts, M, Roberts, D, Rose, A, Rousseau, G, Ryan, B, Saluja, T, Shah, A, Shanmuga, P, Sharma, A, Shawcross, A, Sizer, J, Shankar-Hari, M, Smith, R, Snelson, C, Spittle, N, Staines, N, Stambach, T, Stewart, R, Subudhi, P, Szakmany, T, Tatham, K, Thomas, J, Thompson, C, Tridente, A, Tupper-Carey, D, Twagira, M, Ustianowski, A, Vallotton, N, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Walden, A, Welters, I, Whitehouse, T, Whittaker, P, Whittington, A, Papineni, P, Wijesinghe, M, Williams, M, Wilson, L, Cole, S, Winchester, S, Wiselka, M, Wolverson, A, Wooton, D, Workman, A, Yates, B, Young, P, Beale, R, Bretherick, A, Clohisey, S, Fourman, M, Furniss, J, Gountouna, E, Grimes, G, Haley, C, Harrison, D, Hayward, C, Keating, S, Klaric, L, Klenerman, P, Law, A, Meynert, A, Millar, J, Pairo-Castineira, E, Parkinson, N, Ponting, C, Porteous, D, Rawlik, K, Richmond, A, Rowan, K, Russell, C, Shen, X, Shih, B, Tenesa, A, Vitart, V, Wang, B, Wilson, J, Wu, Y, Yang, J, Yang, Z, Zechner, M, Zhai, R, Zheng, C, Norman, L, Pius, R, Drake, T, Fairfield, C, Mclean, K, Murphy, D, Shaw, C, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Leeming, G, Wham, M, Hendry, R, Scott-Brown, J, Begg, C, Hinds, C, Wai Ho, A, Horby, P, Knight, J, Ling, L, Maslove, D, Mcauley, D, Montgomery, H, Openshaw, P, Summers, C, Walsh, T, Armstrong, L, Bates, H, Dooks, E, Farquhar, F, Hairsine, B, Mcparland, C, Packham, S, Alldis, Z, Astin-Chamberlain, R, Bibi, F, Biddle, J, Blow, S, Bolton, M, Borra, C, Bowles, R, Burton, M, Choudhury, Y, Collier, D, Cox, A, Easthope, A, Ebano, P, Fotiadis, S, Gurasashvili, J, Halls, R, Hartridge, P, Kallon, D, Kassam, J, Lancoma-Malcolm, I, Matharu, M, May, P, Mitchelmore, O, Newman, T, Patel, M, Pheby, J, Pinzuti, I, Prime, Z, Prysyazhna, O, Shiel, J, Taylor, M, Tierney, C, Wood, S, Zak, A, Zongo, O, Forsey, M, Nicholson, A, Riches, J, Vertue, M, Wasson, C, Finn, S, Green, J, Collins, E, King, B, Grauslyte, L, Hussain, M, Pogreban, T, Rosaroso, L, Salciute, E, Franke, G, Wong, J, George, A, Akeroyd, L, Bano, S, Bromley, M, Gurr, L, Lawton, T, Morgan, J, Sellick, K, Warren, D, Wilkinson, B, Mcgowan, J, Ledgard, C, Stacey, A, Pye, K, Bellwood, R, Bentley, M, Loosley, R, Mcguinness, H, Tench, H, Wolf-Roberts, R, Gibson, S, Lyle, A, Mcneela, F, Radhakrishnan, J, Hughes, A, Ali, A, Brady, M, Dale, S, Dance, A, Gledhill, L, Greig, J, Hanson, K, Holdroyd, K, Home, M, Kelly, D, Kitson, R, Matapure, L, Melia, D, Mellor, S, Nortcliffe, T, Pinnell, J, Robinson, M, Shaw, L, Shaw, R, Thomis, L, Wilson, A, Wood, T, Bayo, L, Merwaha, E, Ishaq, T, Hanley, S, Antcliffe, D, Banach, D, Brett, S, Coghlan, P, Fernandez, Z, Gordon, A, Rojo, R, Arias, S, Templeton, M, Jha, R, Krishnamurthy, V, Lim, L, Bi, R, Scholefield, B, Ashton, L, Williams, A, Cheyne, C, Saunderson, A, Allan, A, Anderson, F, Kaye, C, Liew, J, Medhora, J, Scott, T, Trumper, E, Botello, A, Polgarova, P, Stroud, K, Meaney, E, Jones, M, Ng, A, Agrawal, S, Pathan, N, White, D, Daubney, E, Elston, K, Parker, R, Reddy, A, Turner-Bone, I, Wilding, L, Harding, P, Jacob, R, Jones, C, Denmade, C, Croft, M, White, I, Griffin, D, Muchenje, N, Mupudzi, M, Partridge, R, Conyngham, J, Thomas, R, Wright, M, Corral, M, Bastion, V, Clarke, D, David, B, Kent, H, Lorusso, R, Lubimbi, G, Murdoch, S, Penacerrada, M, Thomas, A, Valentine, J, Vochin, A, Wulandari, R, Djeugam, B, Dawson, J, Garrioch, S, Tolson, M, Aldridge, J, de Almeida Martins, L, Carungcong, J, Beavis, S, Dale, K, Gascoyne, R, Hawes, J, Pritchard, K, Stevenson, L, Whileman, A, Cowley, A, Highgate, J, Crawley, R, Crew, A, Cunningham, M, Daniels, A, Harrison, L, Hope, S, Inweregbu, K, Jones, S, Lancaster, N, Matthews, J, Wray, G, Benham, L, Bradshaw, Z, Brown, J, Caswell, M, Melling, S, Preston, S, Slawson, N, Stoddard, E, Warden, S, Combes, E, Joefield, T, Monnery, S, Beech, V, Trotman, S, Hopkins, B, Scriven, J, Thrasyvoulou, L, Willis, H, Anderson, S, Birch, J, Hammerton, K, O’Leary, R, Abernathy, C, Foster, L, Gratrix, A, Martinson, V, Parkinson, P, Stones, E, Carbral-Ortega, L, Kapoor, R, Loader, D, Castle, K, Brandwood, C, Smith, L, Clark, R, Birchall, K, Kolakaluri, L, Baines, D, Sukumaran, A, Mapfunde, I, Meredith, M, Morris, L, Ryan, L, Clark, A, Sampson, J, Peters, C, Dent, M, Langley, M, Wei, S, Andrew, A, Chablani, M, Kirkby, A, Netherton, K, Bates, M, Dasgin, J, Gill, J, Nilsson, A, Apetri, E, Basikolo, C, Blackledge, B, Catlow, L, Charles, B, Doonan, R, Harris, J, Harvey, A, Horner, D, Knowles, K, Lomas, D, Lyons, C, Marsden, T, Mclaughlan, D, Mcmorrow, L, Pendlebury, J, Perez, J, Poulaka, M, Proudfoot, N, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Michael, A, Collis, M, Clark, M, Coulding, M, Jude, E, Mccormick, J, Mercer, O, Potla, D, Rehman, H, Savill, H, Turner, V, Davey, M, Golden, D, Seaman, R, Hunt, J, Dearden, J, Dobson, E, Mulcahy, M, Munt, S, O’Connor, G, Philbin, J, Rishton, C, Tully, R, Winnard, S, Cagova, L, Fofano, A, Garner, L, Holcombe, H, Mepham, S, Mitchell, A, Mwaura, L, Praman, K, Zamikula, J, Bercades, G, Brealey, D, Hass, I, Maccallum, N, Martir, G, Raith, E, Reyes, A, Smyth, D, Taylor, A, Hughes, R, Thomas, H, Rees, A, Duskova, M, Phipps, J, Brooks, S, Edwards, M, Alexander, P, Allen, S, Bradley-Potts, J, Brantwood, C, Egan, J, Felton, T, Padden, G, Ward, L, Moss, S, Glasgow, S, Beesley, K, Board, S, Kubisz-Pudelko, A, Lewis, A, Perry, J, Pippard, L, Wood, D, Buckley, C, Brown, A, Gregory, J, O’Connell, S, Smith, T, Belagodu, Z, Fuller, B, Gherman, A, Olufuwa, O, Paramsothy, R, Stuart, C, Oakley, N, Kamundi, C, Tyl, D, Collins, K, Silva, P, Taylor, J, King, L, Coates, C, Crowley, M, Wakefield, P, Beadle, J, Johnson, L, Sargeant, J, Anderson, M, Jardine, C, Williams, D, Parris, V, Quaid, S, Watson, E, Melville, J, Naisbitt, J, Joseph, R, Lazo, M, Walton, O, Neal, A, Hill, M, Kannan, T, Wild, L, Allan, E, Darlington, K, Davies, F, Easton, J, Kumar, S, Lean, R, Menzies, D, Pugh, R, Qiu, X, Davies, L, Williams, H, Scanlon, J, Davies, G, Mackay, C, Lewis, J, Rees, S, Coetzee, S, Gales, A, Raj, M, Sell, C, Langton, H, Watters, M, Novis, C, Arbane, G, Bociek, A, Campos, S, Grau, N, Jones, T, Lim, R, Marotti, M, Whitton, C, Barron, A, Collins, C, Kaul, S, Passmore, H, Prendergast, C, Reed, A, Rogers, P, Shokkar, R, Woodruff, M, Middleton, H, Polgar, O, Nolan, C, Thwaites, V, Mahay, K, Sri-Chandana, C, Scherewode, J, Stephenson, L, Marsh, S, Bancroft, H, Bellamy, M, Carmody, M, Daglish, J, Moore, F, Rhodes, J, Sangombe, M, Kadiri, S, Ayers, A, Harrison, W, North, J, Cavazza, A, Cockrell, M, Corcoran, E, Depante, M, Finney, C, Jerome, E, Mcphail, M, Nayak, M, Noble, H, O’Reilly, K, Pappa, E, Saha, R, Saha, S, Smith, J, Knighton, A, Gill, M, Paul, P, Ratnam, V, Shelton, S, Wynter, I, Baptista, D, Crowe, R, Fernandes, R, Herdman-Grant, R, Joseph, A, Loveridge, A, Mckenley, I, Morino, E, Naranjo, A, Simms, R, Sollesta, K, Swain, A, Venkatesh, H, Khera, J, Fox, J, Barber, R, Hewitt, C, Hilldrith, A, Jackson-Lawrence, K, Shepardson, S, Wills, M, Butler, S, Tavares, S, Cunningham, A, Hindale, J, Arif, S, George, L, Twiss, S, Wright, D, Holland, M, Keenan, N, Lyons, M, Wassall, H, Marsh, C, Mahenthran, M, Carter, E, Kong, T, Adanini, O, Bhatia, N, Msiska, M, Mew, L, Mwaura, E, Williams, F, Wren, L, Sutherland, S, Battle, C, Brinkworth, E, Harford, R, Murphy, C, Newey, L, Rees, T, Arnold, S, Hardy, J, Houlden, H, Moncur, E, Tariq, A, Tucci, A, Convery, K, Fottrell-Gould, D, Hudig, L, Keshet-Price, J, Randell, G, Stammers, K, Abdelrazik, M, Bakthavatsalam, D, Elhassan, M, Ganesan, A, Haldeos, A, Moreno-Cuesta, J, Purohit, D, Vincent, R, Xavier, K, Rohit, K, Alasdair, F, Saleem, M, David, C, Jenkins, S, Lamond, Z, Wall, A, Reynolds, J, Campbell, H, Thompsom, M, Dodds, S, Duffy, S, Butcher, D, O’Sullivan, S, Butterworth-Cowin, N, Deacon, B, Hibbert, M, Pothecary, C, Tetla, D, Woodford, C, Durga, L, Kennard-Holden, G, de Gordoa, L, Peasgood, E, Phillips, C, Skinner, D, Gaylard, J, Mullan, D, Newman, J, Davies, E, Roche, L, Sathe, S, Brimfield, L, Daly, Z, Pogson, D, Rose, S, Collins, A, Khaliq, W, Gude, E, Allen, L, Beranova, E, Crisp, N, Deery, J, Hazelton, T, Knight, A, Price, C, Tilbey, S, Turki, S, Turney, S, Giles, J, Booth, S, Bell, G, English, K, Katary, A, Wilcox, L, Campbell, R, Clarke, N, Whiteside, J, Mascarenhas, M, Donaldson, A, Matheson, J, Barrett, F, O’Hara, M, O’Keefe, L, Bradley, C, Walker, R, Maynard, V, Patel, T, Smith, M, Kazi, A, Hartley, J, Dykes, J, Hijazi, M, Keith, S, Khan, M, Ryan-Smith, J, Springle, P, Truman, N, Saad, S, Coleman, D, Fine, C, Matt, R, Gay, B, Dalziel, J, Ali, S, Goodchild, D, Harling, R, Bhatterjee, R, Goddard, W, Davison, C, Duberly, S, Hargreaves, J, Bolton, R, Verlander, M, Blackman, H, Creagh-Brown, B, Donlon, S, Michalak-Glinska, N, Mtuwa, S, Pristopan, V, Salberg, A, Smith, E, Stone, S, Piercy, C, Verula, J, Burda, D, Montaser, R, Harden, L, Mayangao, I, Marriott, C, Bradley, P, Harris, C, Cooper, J, Finch, C, Liderth, S, Quinn, A, Waddington, N, Fidler, K, Tagliavini, E, Donnelly, K, Abel, L, Brett, M, Digby, B, Gemmell, L, Hornsby, J, Macgoey, P, O’Neil, P, Price, R, Rodden, N, Rooney, K, Sundaram, R, Thomson, N, Flanagan, R, Hughes, G, Latham, S, Mckenna, E, Anderson, J, Hull, R, Rhead, K, Branney, D, Frankham, J, Pitts, S, White, N, Cristiano, D, Dormand, N, Farzad, Z, Gummadi, M, Liyanage, K, Salmi, S, Sloane, G, Varghese, M, Zborowski, A, Bean, S, Burt, K, Spivey, M, Eastgate-Jackson, C, Filipe, H, Martin, D, Maharajh, A, Garcia, S, De Neef, M, Lynch, C, Howe, G, Singh, J, Turner, K, Ellis, H, Stroud, N, Cherian, S, Cutler, S, Heron, A, Roynon-Reed, A, Williams, G, Richards, O, Cheema, Y, Ahmad, N, Barker, J, Bauchmuller, K, Bird, S, Cawthron, K, Harrington, K, Jackson, Y, Kibutu, F, Lenagh, B, Masuko, S, Raithatha, A, Wiles, M, Willson, J, Newell, H, Lye, A, Nwafor, L, Jarman, C, Rowland-Jones, S, Foote, D, Cole, J, Watson, J, Hesseldon, L, Macharia, I, Chetam, L, Ford, A, Housley, K, Milner, L, Hanratty, H, Trower, H, Phillips, P, Oxspring, S, Donne, B, Bevan, E, Martin, J, Trodd, D, Watson, G, Brown, C, Bunni, L, Jennings, C, Latif, M, Marshall, R, Subramanian, G, Bandla, N, Gellamucho, M, Davies, M, Trim, F, Eapen, B, Ahmed, C, Baines, B, Clamp, S, Colley, J, Haq, R, Hayes, A, Hulme, J, Joseph, S, Kumar, R, Maqsood, Z, Purewal, M, Chandler, B, Elliott, K, Mallinson, J, Turnbull, A, Dent, K, Horsley, E, Akhtar, M, Pearson, S, Potoczna, D, Spencer, S, Blakemore, H, Borislavova, B, Faulkner, B, Gendall, E, Goff, E, Hayes, K, Thomas, M, Worner, R, Smith, K, Stephens, D, Delgado, C, Dawson, D, Ding, L, Durrant, G, Ezeobu, O, Farnell-Ward, S, Harrison, A, Kanu, R, Leaver, S, Maccacari, E, Manna, S, Saluzzio, R, Queiroz, J, Samakomva, T, Sicat, C, Texeira, J, Da Gloria, E, Lisboa, A, Rawlins, J, Mathew, J, Kinch, A, Hurt, W, Shah, N, Clark, V, Thanasi, M, Yun, N, Patel, K, Crickmore, V, Debreceni, G, Wilkins, J, Nicol, L, Burn, I, Hambrook, G, Manso, K, Penn, R, Shanmugasundaram, P, Tebbutt, J, Thornton, D, Rostron, A, Roy, A, Woods, L, Cornell, S, Wakinshaw, F, Rogerson, K, Jarmain, J, Anderson, P, Archer, K, Austin, K, Davis, C, Durie, A, Kelsall, O, Thrush, J, Vigurs, C, Wood, H, Tranter, H, Cowley, N, Mcalindon, M, Digby, S, Low, E, Morgan, A, Cother, N, Rankin, T, Clayton, S, Mccurdy, A, Allibone, S, Mary-Genetu, R, Patel, A, Mac, A, Murphy, A, Mahjoob, P, Nazari, R, Worsley, L, Fagan, A, Mohamed Ali, I, Beaumont, K, Blunt, M, Coton, Z, Curgenven, H, Elsaadany, M, Fernandes, K, Ally, S, Rangarajan, H, Sarathy, V, Selvanayagam, S, Vedage, D, White, M, Fernandez-Roman, J, Hamilton, D, Johnson, E, Johnston, B, Martinez, M, Mulla, S, Waite, A, Waugh, V, Williams, K, Bemand, T, Black, E, Rosa, A, Howle, R, Jhanji, S, Baikady, R, Thomas, B, Halkes, M, Mercer, P, Thornton, L, West, J, Baird, T, Ruddy, J, Reece-Anthony, R, Birt, M, Cowton, A, Kay, A, Kent, M, Potts, K, Wilkinson, A, Naylor, S, Brown, E, Purvis, S, Davies, R, Duffin, D, Hill, H, Player, B, Thomas, E, Beith, C, Black, K, Clements, S, Morrison, A, Strachan, D, Clarkson, M, D’Sylva, S, Norman, K, Coventry, T, Fowler, S, Mcgregor, A, Brady, A, Chan, R, Mcivor, S, Prady, H, Whittle, H, Mathew, B, Clapham, M, Harper, R, Poultney, U, Rice, P, Mutch, R, Baird, Y, Butler, A, Chadbourn, I, Folkes, L, Fox, H, Gardner, A, Gomez, R, Hobden, G, King, K, Margarson, M, Martindale, T, Meadows, E, Raynard, D, Thirlwall, Y, Helm, D, Margalef, J, Greer, S, Shuker, K, Smuts, S, Duffield, J, Smith, O, Mallon, L, Claire, W, Birkinshaw, I, Carter, J, Howard, K, Ingham, J, Joy, R, Pearson, H, Roche, S, Scott, Z, Knights, E, Price, A, Thorpe, C, Abraheem, A, Bamford, P, Cawley, K, Dunmore, C, Faulkner, M, Girach, R, Jeffrey, H, Jones, R, London, E, Nagra, I, Nasir, F, Sainsbury, H, Smedley, C, Khade, R, Sundar, A, Tsinaslanidis, G, Behan, T, Burnett, C, Hatton, J, Heeney, E, Mitra, A, Newton, M, Pollard, R, Stead, R, Bough, L, Goodsell, J, Tutton, R, Williams, P, Williams, S, Winter-Goodwin, B, Auld, F, Donnachie, J, Edmond, I, Prentice, L, Runciman, N, Salutous, D, Symon, L, Todd, A, Turner, P, Short, A, Sweeney, L, Murdoch, E, Senaratne, D, Burns, K, Higham, A, Anderson, T, O’Malley, L, Rad, L, Rogers, N, Saunderson, P, Allison, K, Afolabi, D, Whitbread, J, Jones, D, Dore, R, Lankester, L, Nikitas, N, Wells, C, Stowe, B, Spencer, K, Cathcart, S, Duffy, K, Puxty, A, Puxty, K, Turner, L, Ireland, J, Semple, G, Barry, P, Hilltout, P, Evitts, J, Tyler, A, Waldron, J, Irvine, V, Shelley, B, Akinkugbe, O, Bamford, A, Beech, E, Belfield, H, Bell, M, Davies, C, Jones, G, Mchugh, T, Meghari, H, O’Neill, L, Ray, S, Tomas, A, Gorman, C, Gupta, A, Timlick, E, Brady, R, Bonner, S, Hugill, K, Jones, J, Liggett, S, Bashyal, A, Davidson, N, Hutton, P, Mckechnie, S, Flint, N, Rekha, P, Hales, D, Cruz, C, Gopal, S, Harris, N, Lake, V, Metherell, S, Radford, E, Clement, I, Gulati, A, Hays, C, Webster, K, Hudson, A, Webster, A, Stephenson, E, Mccormack, L, Slater, V, Nixon, R, Hanson, H, Fearby, M, Kelly, S, Bridgett, V, Robinson, P, Almaden-Boyle, C, Austin, P, Cabrelli, L, Casey, M, Chapman, S, Whyte, C, Brayne, A, Fisher, E, Jackson, P, Kaye, D, Love, N, Parkin, J, Tuckey, V, van Koutrik, L, Carter, S, Andrew, B, Findlay, L, Adams, K, Bruce, M, Connolly, K, Duncan, T, T. -Michael, H, Lindergard, G, Hey, S, Fox, C, Alfonso, J, Durrans, L, Guerin, J, Hruska, M, Eltayeb, A, Lamb, T, Hodgkiss, T, Cooper, L, Rothwell, J, Dennis, C, Srikaran, S, Sukha, A, Davies, K, O’Brien, L, Omar, Z, Perkins, E, Lewis, T, Sutherland, I, Brooke, H, Buckley, S, Suarez, J, Charlesworth, R, Hansson, K, Norris, J, Poole, A, Sandhu, R, Sloan, B, Smithson, E, Thirumaran, M, Wagstaff, V, Metcalfe, A, Camsooksai, J, Humphrey, C, Wadams, B, Death, Y, Adams, C, Agasou, A, Arden, T, Bowes, A, Boyle, P, Beekes, M, Button, H, Capps, N, Carnahan, M, Carter, A, Childs, D, Donaldson, D, Hard, K, Hurford, F, Hussain, Y, Javaid, A, Jose, S, Leigh, M, Martin, T, Millward, H, Motherwell, N, Rikunenko, R, Stickley, J, Summers, J, Ting, L, Tivenan, H, Tonks, L, Wilcox, R, Bokhari, M, Lucas, R, Mccormick, W, Ritzema, J, Sanderson, A, Wild, H, Baxter, N, Henderson, S, Kennedy-Hay, S, Rooney, L, Sim, M, Mccreath, G, Brunton, M, Caterson, J, Coles, H, Frise, M, Rai, S, Keating, L, Tilney, E, Bartley, S, Bhuie, P, Downes, C, Holding, K, Riches, K, Hilton, M, Hayman, M, Subramanian, D, Daniel, P, Zitter, L, Benyon, S, Marriott, S, Park, L, Keenan, S, Gordon, E, Quinn, H, Baines, K, Andrew, G, Barclay, L, Callaghan, M, Clark, S, Hope, D, Marshall, L, Mcculloch, C, Briton, K, Singleton, J, Birch, S, Simpson, K, Craig, J, Demetriou, C, Eckbad, C, Hierons, S, Howie, L, Mitchard, S, Ramos, L, Serrano-Ruiz, A, White, K, Kelly, F, Amin, V, Anastasescu, E, Anumakonda, V, Karthik, K, Kausar, R, Reid, K, Imeson-Wood, J, Bellini, A, Bryant, J, Pickard, A, Roe, N, Sowter, J, Howlett, A, Criste, K, Cusack, R, Golder, K, Golding, H, Jones, O, Leggett, S, Male, M, Marani, M, Prager, K, Williams, T, Roberts, B, Salmon, K, Gondo, P, Hadebe, B, Kayani, A, Masunda, B, Ahmed, A, Morris, A, Jakkula, S, Long, K, Whiteley, S, Wilby, E, Ogg, B, Moultrie, S, Odam, M, Bewley, J, Garland, Z, Grimmer, L, Gumbrill, B, Sweet, K, Webster, D, Efford, G, Bennett, S, Goodwin, E, Jackson, M, Kent, A, Tibke, C, Woodyatt, W, Zaki, A, Daniel, A, Finn, J, Bremmer, P, Allan, J, Geary, T, Houston, G, Meikle, A, O’Brien, P, Bell, D, Boyle, R, Douglas, K, Glass, L, Lee, E, Lennon, L, Rattray, A, Charnock, R, Mcfarland, D, Cosgrove, D, Attwood, B, Parsons, P, Carmody, S, Oblak, M, Popescu, M, Thankachen, M, Baruah, R, Morris, S, Ferguson, S, Shepherd, A, Altabaibeh, A, Alvaro, A, Gilbert, K, Ma, L, Mostoles, L, Parmar, C, Jetha, C, Booker, L, Pratley, A, Cosier, T, Millen, G, Schumacher, N, Weston, H, Rand, J, Alex, B, Bach, B, Barclay, W, Bogaert, D, Chand, M, Cooke, G, Docherty, A, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, C, Harrison, E, Hiscox, J, Ijaz, S, Khoo, S, Lim, W, Mentzer, A, Merson, L, Noursadeghi, M, Moore, S, Palmarini, M, Paxton, W, Pollakis, G, Price, N, Rambaut, A, Robertson, D, Sancho-Shimizu, V, Scott, J, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Tedder, R, Thomson, E, Roger Thompson, A, Thwaites, R, Turtle, L, Palmieri, C, Swann, O, Zambon, M, Dumas, M, Griffin, J, Takats, Z, Chechi, K, Andrikopoulos, P, Osagie, A, Olanipekun, M, Liggi, S, Lewis, M, Correia, G, Sands, C, Takis, P, Maslen, L, Greenhalf, W, Shaw, V, Mcdonald, S, Ahmed, K, Ashworth, M, Asiimwe, I, Bakshi, S, Barlow, S, Booth, L, Brennan, B, Bullock, K, Catterall, B, Clark, J, Clarke, E, Cox, H, Dincarslan, O, Dunn, C, Dyer, P, Elliott, A, Evans, A, Finch, L, Fisher, L, Foster, T, Garcia-Dorival, I, Gunning, P, Hartley, C, Jensen, R, Khandaker, S, Kiy, R, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, L, Mancini, M, Mcevoy, L, Mclauchlan, J, Metelmann, S, Miah, N, Middleton, J, Mitchell, J, Murphy, E, Penrice-Randal, R, Pilgrim, J, Prince, T, Reynolds, W, Ridley, P, Sales, D, Shears, R, Small, B, Subramaniam, K, Szemiel, A, Taggart, A, Tanianis-Hughes, J, Trochu, E, van Tonder, L, Wilcock, E, Zhang, J, Flaherty, L, Maziere, N, Cass, E, Carracedo, A, Carlucci, N, Holmes, A, Massey, H, Murphy, L, Wrobel, N, Mccafferty, S, Morrice, K, Maclean, A, Armstrong, R, Boz, C, Coutts, A, Cullum, L, Day, N, Donnelly, L, Duncan, E, Fawkes, A, Finernan, P, Gilchrist, T, Golightly, A, Hafezi, K, Law, D, Law, R, Law, S, Macgillivray, L, Mal, H, Mcmaster, E, Meikle, J, Oosthuyzen, W, Paterson, T, Stenhouse, A, Swets, M, Szoor-McElhinney, H, Taneski, F, Wackett, T, Ward, M, Weaver, J, Coyle, J, Gallagher, B, Lidstone-Scott, R, Schon, K, Furlong, A, Biggs, H, Griffiths, F, Andrews, E, Brickell, K, Smyth, M, Carson, G, Hardwick, H, Donohue, C, COVID-19 Host Genetics Initiative, Karjalainen, J., Neale, B.M., Daly, M., Ganna, A., Liao, R.G., Pathak, G.A., Andrews, S.J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E.C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M.A., Wendt, F.R., Savage, J., Sloofman, L., Butler-Laporte, G., Kim, H.N., Kanoni, S., Okada, Y., Byun, J., Han, Y., Uddin, M.J., Smith, G.D., Willer, C.J., Buxbaum, J.D., Mehtonen, J., Finucane, H., Cordioli, M., Martin, A.R., Zhou, W., Pasaniuc, B., Julienne, H., Aschard, H., Shi, H., Yengo, L., Polimanti, R., Ghoussaini, M., Schwartzentruber, J., Dunham, I., Chwialkowska, K., Francescatto, M., Trankiem, A., Balaconis, M.K., Davis, L., Lee, S., Priest, J., Renieri, A., Sankaran, V.G., van Heel, D., Deelen, P., Richards, J.B., Nakanishi, T., Biesecker, L., Kerchberger, V.E., Baillie, J.K., Mari, F., Bernasconi, A., Baillie, S.C., Canakoglu, A., Wolford, B., Faucon, A., Dutta, A.K., Schurmann, C., Harry, E., Birney, E., Nguyen, H., Nasir, J., Kaunisto, M., Solomonson, M., Dueker, N., Vadgama, N., Limou, S., Rahmouni, S., Mbarek, H., Darwish, D., Uddin, M.M., Albertos, R., Pérez-Tur, J., Li, R., Folkersen, L., Moltke, I., Koelling, N., Teumer, A., Kousathanas, A., Utrilla, A., Verdugo, R.A., Zárate, R., Medina-Gómez, C., Gómez-Cabrero, D., Carnero-Montoro, E., Cadilla, C.L., Moreno-Estrada, A., Garmendia, A., Moya, L., Sedaghati-Khayat, B., Boua, P.R., Favé, M.J., Francioli, L., Lemaçon, A., Migeotte, I., Patel, S., Varnai, R., Szentpeteri, J.L., Sipeky, C., Colombo, F., von Hohenstaufen, K., Lio, P., Vallerga, C., Wang, Q., Tanigawa, Y., Im, H., Han, C., Song, H., Lim, J., Lee, Y., Kim, S., Im, S., Atanasovska, B., Ahmad, H.F., Boer, C., Jansen, P., Franke, L., Kaja, E., Pasko, D., Kennis-Szilagyi, I., Kornilov, S.A., Prijatelj, V., Prokić, I., Sivanadhan, I., Perumal, S., Esmaeeli, S., Pearson, N.M., Auton, A., Shelton, J.F., Shastri, A.J., Filshtein-Sonmez, T., Coker, D., Symons, A., Esparza-Gordillo, J., Aslibekyan, S., O'Connell, J., Ye, C., Weldon, C.H., Perera, M., O'Leary, K., Tuck, M., O'Brien, T., Meltzer, D., O'Donnell, P., Nutescu, E., Yang, G., Alarcon, C., Herrmann, S., Mazurek, S., Banagan, J., Hamidi, Z., Barbour, A., Raffat, N., Moreno, D., Friedman, P., Ferwerda, B., van de Beek, D., Brouwer, M.C., Vlaar, APJ, Wiersinga, W.J., Posthuma, D., Tissink, E., Koos Zwinderman, A.H., Uffelmann, E., van Agtmael, M., Algera, A.G., van Baarle, F., Bax, D., Beudel, M., Jan Bogaard, H., Bomers, M., Bonta, P.I., Bos, L., Botta, M., de Brabander, J., de Bree, G., de Bruin, S., Bugiani, M., Bulle, E., Chouchane, O., Cloherty, A., Dongelmans, D., Elbers, P., Fleuren, L., Geerlings, S., Geerts, B., Geijtenbeek, T., Girbes, A., Goorhuis, B., Grobusch, M.P., Hafkamp, F., Hagens, L., Hamann, J., Harris, V., Hemke, R., Hermans, S.M., Heunks, L., Hollmann, M., Horn, J., Hovius, J.W., de Jong, M.D., Koning, R., van Mourik, N., Nellen, J., Nossent, E.J., Paulus, F., Peters, E., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, J., Reijnders, T., Schinkel, M., Schultz, M.J., Schuurman, A., Sigaloff, K., Smit, M., Stijnis, C.S., Stilma, W., Teunissen, C., Thoral, P., Tsonas, A., van der Valk, M., Veelo, D., de Vries, H., van Vugt, M., Wouters, D., Minnaar, R.P., Kromhout, A., van Uffelen, KWJ, Wolterman, R.A., Roberts, G., Park, D., Ball, C.A., Coignet, M., McCurdy, S., Knight, S., Partha, R., Rhead, B., Zhang, M., Berkowitz, N., Gaddis, M., Noto, K., Ruiz, L., Pavlovic, M., Hong, E.L., Rand, K., Girshick, A., Guturu, H., Baltzell, A.H., Guntz, J., Beguin, Y., Pigazzini, S., Nkambule, L., Bouysran, Y., Busson, A., Peyrassol, X., Wilkin, F., Pichon, B., Smits, G., Vandernoot, I., Goffard, J.C., Georges, M., Moutschen, M., Misset, B., Darcis, G., Guiot, J., Jadot, L., Azarzar, S., Dellot, P., Gofflot, S., Claassen, S., Bertrand, A., Parzibut, G., Clarinval, M., Moermans, C., Malaise, O., El Kandoussi, K., Thonon, R., Huynen, P., Mesdagh, A., Melo, S., Jacques, N., Di Valentin, E., Giroule, F., Collignon, A., Radermecker, C., Lebrun, M., Perée, H., Latour, S., Barada, O., Sanchez, J., Josse, C., Boujemla, B., Meunier, M., Mariavelle, E., Anania, S., Gazon, H., Juszczak, D., Fadeur, M., Camby, S., Meuris, C., Thys, M., Jacques, J., Henket, M., Léonard, P., Frippiat, F., Giot, J.B., Sauvage, A.S., Von Frenckell, C., Mni, M., Wéry, M., Staderoli, A., Belhaj, Y., Lambermont, B., Morrison, D.R., Mooser, V., Forgetta, V., Ghosh, B., Laurent, L., Belisle, A., Henry, D., Abdullah, T., Adeleye, O., Mamlouk, N., Kimchi, N., Afrasiabi, Z., Rezk, N., Vulesevic, B., Bouab, M., Guzman, C., Petitjean, L., Tselios, C., Xue, X., Afilalo, J., Afilalo, M., Oliveira, M., Brenner, B., Brassard, N., Durand, M., Schurr, E., Lepage, P., Ragoussis, J., Auld, D., Chassé, M., Kaufmann, D.E., Lathrop, G.M., Adra, D., Davis, L.K., Cox, N.J., Below, J.E., Sealock, J.M., Faucon, A.B., Shuey, M.M., Polikowsky, H.G., Petty, L.E., Shaw, D.M., Chen, H.H., Zhu, W., Ludwig, K.U., Schröder, J., Maj, C., Rolker, S., Nöthen, M.M., Fazaal, J., Keitel, V., Jensen, B.O., Feldt, T., Kurth, I., Marx, N., Dreher, M., Pink, I., Cornberg, M., Illig, T., Lehmann, C., Schommers, P., Augustin, M., Rybniker, J., Knopp, L., Eggermann, T., Volland, S., Altmüller, J., Berger, M.M., Brenner, T., Hinney, A., Witzke, O., Bals, R., Herr, C., Ludwig, N., Walter, J., Fuchsberger, C., Pattaro, C., De Grandi, A., Pramstaller, P., Emmert, D., Melotti, R., Foco, L., Mascalzoni, D., Gögele, M., Domingues, F., Hicks, A., Gignoux, C.R., Wicks, S.J., Crooks, K., Barnes, K.C., Daya, M., Shortt, J., Rafaels, N., Chavan, S., Goldstein, D.B., Kiryluk, K., Sengupta, S., Chung, W., Reilly, M.P., Khan, A., Wang, C., Povysil, G., Bhardwaj, N., Gharavi, A.G., Ionita-Laza, I., Shang, N., O'Byrne, S.M., Nandakumar, R., Menon, A., So, Y.S., Hod, E., Pendrick, D., Park, S.K., Kim, H.L., Kang, C.K., Lee, H.J., Song, K.H., Jae Yoon, K., Paik, N.J., Seok, W., Yoon, H., Joo, E.J., Chang, Y., Ryu, S., Park, W.B., Su Park, J., Un Park, K., Ham, S.Y., Jung, J., Kim, E.S., Kim, H.B., Ellinghaus, D., Degenhardt, F., Cáceres, M., Juzenas, S., Lenz, T.L., Albillos, A., Julià, A., Heidecker, B., Garcia, F., Kurth, F., Tran, F., Hanses, F., Zoller, H., Holter, J.C., Fernández, J., Sander, L.E., Rosenstiel, P., Koehler, P., de Cid, R., Asselta, R., Schreiber, S., Hehr, U., Prati, D., Baselli, G., Valenti, L., Bujanda, L., Banales, J.M., Duga, S., D'Amato, M., Romero-Gómez, M., Buti, M., Invernizzi, P., Franke, A., Hov, J.R., Karlsen, T.H., Folseraas, T., Maya-Miles, D., Teles, A., Azuure, C., Wacker, E.M., Uellendahl-Werth, F., ElAbd, H., Arora, J., Lerga-Jaso, J., Wienbrandt, L., Rühlemann, M.C., Wendorff, M., Vadla, M.S., Lenning, O.B., Özer, O., Myhre, R., Raychaudhuri, S., Tanck, A., Gassner, C., Hemmrich-Stanisak, G., Kässens, J., Figuera Basso, M.E., Schulzky, M., Wittig, M., Braun, N., Wesse, T., Albrecht, W., Yi, X., Ortiz, A.B., Chercoles, A.G., Ruiz, A., Mantovani, A., Holten, A.R., Mayer, A., Cherubini, A., Protti, A., Aghemo, A., Gerussi, A., Ramirez, A., Braun, A., Barreira, A., Lleo, A., Kildal, A.B., Glück, A., Nolla, A.C., Latiano, A., Dyrhol-Riise, A.M., Muscatello, A., Voza, A., Rando-Segura, A., Solier, A., Karina, B., Cortes, B., Mateos, B., Nafria-Jimenez, B., Schaefer, B., Bellinghausen, C., Ferrando, C., Quereda, C., Skurk, C., Thibeault, C., Spinner, C.D., Lange, C., Hu, C., Cappadona, C., Bianco, C., Sancho, C., Lihaug Hoff, D.A., Galimberti, D., Jiménez, D., Pestaña, D., Toapanta, D., Azzolini, E., Scarpini, E., Helbig, E.T., Urrechaga, E., Paraboschi, E.M., Pontali, E., Reverter, E., Navas, E., Arana, E., Sánchez, F.G., Ceriotti, F., Malvestiti, F., Mesonero, F., Pezzoli, G., Lamorte, G., Neb, H., My, I., Hernández, I., de Rojas, I., Galván-Femenia, I., Heyckendorf, J., Badia, J.R., Schneider, J., Goikoetxea, J., Kraft, J., Müller, K.E., Gaede, K.I., Garcia-Etxebarria, K., Tonby, K., Heggelund, L., Izquierdo-Sanchez, L., Sumoy, L., Lippert, L.J., Terranova, L., Garbarino, L., Téllez, L., Roade, L., Ostadreza, M., Intxausti, M., Kogevinas, M., Gutiérrez-Stampa, M.A., Vehreschild, MJGT, Marquié, M., Castoldi, M., Cecconi, M., Boada, M., Seilmaier, M.J., Mazzocco, M., Rodríguez-Gandía, M., Ayo, N.I., Blay, N., Martínez, N., Cornely, O.A., Palmieri, O., Tentorio, P., Rodrigues, P.M., España, P.P., Hoffmann, P., Bacher, P., Suwalski, P., de Pablo, R., Nieto, R., Badalamenti, S., Ciesek, S., Bombace, S., Wilfling, S., Brunak, S., Heilmann-Heimbach, S., Ripke, S., Bahmer, T., Landmesser, U., Protzer, U., Rimoldi, V., Skogen, V., Andrade, V., Moreno, V., Poller, W., Farre, X., Wang, X., Khodamoradi, Y., Karadeniz, Z., de Salazar, A., Palom, A., Garcia-Fernandez, A.E., Blanco-Grau, A., Zanella, A., Bandera, A., Nebel, A., Biondi, A., Caballero-Garralda, A., Gori, A., Lind, A., Fracanzani, A.L., Peschuck, A., Pesenti, A., de la Horra, C., Milani, C., Paccapelo, C., Angelini, C., Cea, C., Muñiz-Diaz, E., Sandoval, E., Calderón, E.J., Solligård, E., Aziz, F., Martinelli-Boneschi, F., Peyvandi, F., Blasi, F., Medrano, F.J., Rodriguez-Frias, F., Müller, F., Grasselli, G., Costantino, G., Cardamone, G., Foti, G., Matullo, G., Kurihara, H., Afset, J.E., Damås, J.K., Ampuero, J., Martín, J., Erdmann, J., Bergan, J., Goerg, S., Ferrusquía-Acosta, J., Quero, J.H., Delgado, J., Guerrero, J.M., Risnes, K., Bettini, L.R., Moreira, L., Gustad, L.T., Santoro, L., Scudeller, L., Riveiro-Barciela, M., Schaefer, M., Carrabba, M., Valsecchi, M.G., Hernandez-Tejero, M., Acosta-Herrera, M., D'Angiò, M., Baldini, M., Cazzaniga, M., Ciccarelli, M., Bocciolone, M., Miozzo, M., Chueca, N., Montano, N., Faverio, P., Preatoni, P., Bonfanti, P., Omodei, P., Castro, P., Ferrer, R., Gualtierotti, R., Gallego-Durán, R., Morilla, R., Haider, S., Marsal, S., Aneli, S., Pelusi, S., Bosari, S., Aliberti, S., Dudman, S., Zheng, T., Pumarola, T., Cejudo, T.G., Monzani, V., Friaza, V., Peter, W., Dopazo, X., May, S., Grimsrud, M.M., Gudbjartsson, D.F., Stefansson, K., Sulem, P., Sveinbjornsson, G., Melsted, P., Norddahl, G., Swerford Moore, K.H., Thorsteinsdottir, U., Holm, H., Alarcón-Riquelme, M.E., Bernardo, D., Martínez-Bueno, M., Rello, S.R., Magi, R., Milani, L., Metspalu, A., Laisk, T., Läll, K., Lepamets, M., Esko, T., Reimann, E., Naaber, P., Laane, E., Pesukova, J., Peterson, P., Kisand, K., Tabri, J., Allos, R., Hensen, K., Starkopf, J., Ringmets, I., Tamm, A., Kallaste, A., Alavere, H., Metsalu, K., Puusepp, M., Kristiansson, K., Koskelainen, S., Perola, M., Donner, K., Kivinen, K., Palotie, A., Bochud, P.Y., Boillat, N., Nussle, S.G., Albrich, W., Pagani, J.L., Zu Bentrup, F.M., Viollet, R.M., Kampouri, E.E., Meuwly, J.Y., D'Acremont, V., Younes, S.E., Albrich, W.C., O'Mahony, L., Kleger, G.R., Kahlert, C.R., Negro, T.R., Carreras, A., Galván-Femenía, I., Farré, X., Cortés, B., Mercader, J.M., Guindo-Martinez, M., Torrents, D., Garcia-Aymerich, J., Castaño-Vinyals, G., Dobaño, C., Gori, M., Mondelli, M.U., Castelli, F., Vaghi, M., Rusconi, S., Montagnani, F., Bargagli, E., Franchi, F., Mazzei, M.A., Cantarini, L., Tacconi, D., Feri, M., Scala, R., Spargi, G., Nencioni, C., Bandini, M., Caldarelli, G.P., Spagnesi, M., Canaccini, A., Ognibene, A., D'Arminio Monforte, A., Girardis, M., Antinori, A., Francisci, D., Schiaroli, E., Scotton, P.G., Panese, S., Scaggiante, R., Monica, M.D., Capasso, M., Fiorentino, G., Castori, M., Aucella, F., Di Biagio, A., Masucci, L., Valente, S., Mandalà, M., Zucchi, P., Giannattasio, F., Coviello, D.A., Mussini, C., Bosio, G., Tavecchia, L., Crotti, L., Rizzi, M., La Rovere, M.T., Sarzi-Braga, S., Bussotti, M., Ravaglia, S., Artuso, R., Perrella, A., Romani, D., Bergomi, P., Catena, E., Vincenti, A., Ferri, C., Grassi, D., Pessina, G., Tumbarello, M., Di Pietro, M., Sabrina, R., Luchi, S., Barbieri, C., Acquilini, D., Andreucci, E., Paciosi, F., Segala, F.V., Tiseo, G., Falcone, M., Lista, M., Poscente, M., De Vivo, O., Petrocelli, P., Guarnaccia, A., Baroni, S., Perticaroli, V., Furini, S., Dei, S., Benetti, E., Picchiotti, N., Sanarico, M., Ceri, S., Pinoli, P., Raimondi, F., Biscarini, F., Stella, A., Bergomi, M., Zguro, K., Capitani, K., Tanfoni, M., Fallerini, C., Daga, S., Baldassarri, M., Fava, F., Frullanti, E., Valentino, F., Doddato, G., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Mencarelli, M.A., Lo Rizzo, C., Pinto, A.M., Beligni, G., Tommasi, A., Di Sarno, L., Palmieri, M., Carriero, M.L., Alaverdian, D., Iuso, N., Inchingolo, G., Busani, S., Bruno, R., Vecchia, M., Belli, M.A., Mantovani, S., Ludovisi, S., Quiros-Roldan, E., Antoni, M.D., Zanella, I., Siano, M., Emiliozzi, A., Fabbiani, M., Rossetti, B., Zanelli, G., Bergantini, L., D'Alessandro, M., Cameli, P., Bennet, D., Anedda, F., Marcantonio, S., Scolletta, S., Guerrini, S., Conticini, E., Frediani, B., Spertilli, C., Donati, A., Guidelli, L., Corridi, M., Croci, L., Piacentini, P., Desanctis, E., Cappelli, S., Verzuri, A., Anemoli, V., Pancrazi, A., Lorubbio, M., Merlini, E., Miraglia, F.G., Venturelli, S., Cossarizza, A., Vergori, A., Gabrieli, A., Riva, A., Andretta, F., Gatti, F., Parisi, S.G., Baratti, S., Piscopo, C., Russo, R., Andolfo, I., Iolascon, A., Carella, M., Merla, G., Squeo, G.M., Raggi, P., Marciano, C., Perna, R., Bassetti, M., Sanguinetti, M., Giorli, A., Salerni, L., Parravicini, P., Menatti, E., Trotta, T., Coiro, G., Lena, F., Martinelli, E., Mancarella, S., Gabbi, C., Maggiolo, F., Ripamonti, D., Bachetti, T., Suardi, C., Parati, G., Bottà, G., Di Domenico, P., Rancan, I., Bianchi, F., Colombo, R., van Heel, D.A., Hunt, K.A., Trembath, R.C., Huang, Q.Q., Martin, H.C., Mason, D., Trivedi, B., Wright, J., Finer, S., Griffiths, C.J., Akhtar, S., Anwar, M., Arciero, E., Ashraf, S., Breen, G., Chung, R., Curtis, C.J., Chowdhury, M., Colligan, G., Deloukas, P., Durham, C., Griffiths, C., Hurles, M., Hussain, S., Islam, K., Lavery, C., Lee, S.H., Lerner, R., MacArthur, D., MacLaughlin, B., Martin, H., Miah, S., Newman, B., Safa, N., Tahmasebi, F., Smith, A.V., Boughton, A.P., Li, K.W., LeFaive, J., Annis, A., Jannes, C.E., Krieger, J.E., Pereira, A.C., Velho, M., Marques, E., Lima, I.R., Tada, M.T., Valino, K., McCarthy, M., Rosenberger, C., Lee, J.E., Chang, D., Hammer, C., Hunkapiller, J., Mahajan, A., Pendergrass, S., Sucheston-Campbell, L., Yaspan, B., Lee, H.S., Shin, E., Jang, H.Y., Kym, S., Kim, Y.S., Jeong, H., Kwon, K.T., Kim, S.W., Kim, J.Y., Jang, Y.R., Kim, H.A., Lee, J.Y., Choe, K.W., Kang, Y.M., Jee, S.H., Jung, K.J., Parikh, V., Ashley, E., Wheeler, M., Rivas, M., Bustamante, C., Pinksy, B., Febbo, P., Farh, K., Schroth, G.P., deSouza, F., Dalton, K., Christle, J., Deboever, C., Szalma, S., Rubinacci, S., Delaneau, O., Gorzynski, J., de Jong, H., Sutton, S., Youlton, N., Joshi, R., Jimenez-Morales, D., Hughes, C., Amar, D., Ioannidis, A., Hershman, S., Kirillova, A., Seo, K., Huang, Y., Shoura, M., Hammond, N., Watson, N., Raja, A., Huang, C., Sahoo, M., Wang, H., Zhen, J., Rakitko, A., Ilinsky, V., Yermakovich, D., Popov, I., Chernitsov, A., Kovalenko, E., Krasnenko, A., Plotnikov, N., Stetsenko, I., Kim, A., Cirulli, E.T., Schiabor Barrett, K.M., Bolze, A., White, S., Washington, N.L., Lu, J.T., Riffle, S., Tanudjaja, F., Ramirez, J.M., Leonetti, N., Neveux, I., Dabe, S., Grzymski, J.J., Esteban Miñano, J.I., Aguirre, L.A., López-Collazo, E., de la Mata Pazos, M., Cerrato, L., Lozano-Rodríguez, R., Avendaño-Ortiz, J., Arcos, V.T., Montalbán-Hernández, K.M., Quiroga, J.V., Pascual-Iglesias, A., Maroun-Eid, C., Martín-Quirós, A., Namkoong, H., Imoto, S., Katayama, K., Fukunaga, K., Kitagawa, Y., Sato, T., Hasegawa, N., Kumanogoh, A., Kimura, A., Ai, M., Tokunaga, K., Kanai, T., Miyano, S., Ogawa, S., Edahiro, R., Sonehara, K., Shirai, Y., Ishii, M., Kabata, H., Masaki, K., Kamata, H., Ikemura, S., Chubachi, S., Okamori, S., Terai, H., Tanaka, H., Morita, A., Lee, H., Asakura, T., Sasaki, J., Morisaki, H., Uwamino, Y., Nanki, K., Mikami, Y., Tomono, K., Kato, K., Matsuda, F., Takahashi, M., Hizawa, N., Takeda, Y., Hirata, H., Shiroyama, T., Miyawaki, S., Suzuki, K., Maeda, Y., Nii, T., Noda, Y., Niitsu, T., Adachi, Y., Enomoto, T., Amiya, S., Hara, R., Takahashi, K., Anzai, T., Hasegawa, T., Ito, S., Koike, R., Endo, A., Uchimura, Y., Miyazaki, Y., Honda, T., Tateishi, T., Tohda, S., Ichimura, N., Sonobe, K., Sassa, C., Nakajima, J., Nannya, Y., Omae, Y., Harada, N., Hiki, M., Takagi, H., Nakamura, A., Tagaya, E., Kawana, M., Arimura, K., Ishiguro, T., Takayanagi, N., Isono, T., Takaku, Y., Takano, K., Anan, R., Nakajima, Y., Nakano, Y., Nishio, K., Ueda, S., Hayashi, R., Tateno, H., Hase, I., Yoshida, S., Suzuki, S., Mitamura, K., Saito, F., Ueda, T., Azuma, M., Nagasaki, T., Yasui, Y., Hasegawa, Y., Mutoh, Y., Yoshiyama, T., Shoko, T., Kojima, M., Adachi, T., Ishikawa, M., Watanabe, K., Manabe, T., Ito, F., Fukui, T., Funatsu, Y., Koh, H., Hirai, Y., Kawashima, H., Narita, A., Niwa, K., Sekikawa, Y., Yoshiya, K., Yoshihara, T., Suzuki, Y., Nakayama, S., Masuzawa, K., Nishi, K., Nishitsuji, M., Tani, M., Inoue, T., Hirano, T., Kobayashi, K., Miyazawa, N., Kimura, Y., Sado, R., Ogura, T., Kitamura, H., Murohashi, K., Nakachi, I., Baba, R., Arai, D., Fuke, S., Saito, H., Kuwahara, N., Fujiwara, A., Okada, T., Baba, T., Noda, J., Mashimo, S., Yagi, K., Shiomi, T., Hashiguchi, M., Odani, T., Mochimaru, T., Oyamada, Y., Mori, N., Izumi, N., Nagata, K., Taki, R., Murakami, K., Yamada, M., Sugiura, H., Hayashi, K., Shimizu, T., Gon, Y., Fujitani, S., Tsuchida, T., Yoshida, T., Kagaya, T., Kita, T., Sakagami, S., Kimizuka, Y., Kawana, A., Nakamura, Y., Ishikura, H., Takata, T., Kikuchi, T., Taniyama, D., Nakamura, M., Kodama, N., Kaneyama, Y., Maeda, S., Nagasaki, Y., Okamoto, M., Ishihara, S., Ito, A., Chihara, Y., Takeuchi, M., Onoi, K., Hashimoto, N., Wakahara, K., Ando, A., Masuda, M., Wakabayashi, A., Watanabe, H., Sageshima, H., Nakada, T.A., Abe, R., Shimada, T., Kawamura, K., Ichikado, K., Nishiyama, K., Yamasaki, M., Hashimoto, S., Kusaka, Y., Ohba, T., Isogai, S., Takada, M., Kanda, H., Komase, Y., Sano, F., Asano, K., Oguma, T., Harada, M., Takahashi, T., Shibusawa, T., Abe, S., Kono, Y., Togashi, Y., Izumo, T., Inomata, M., Awano, N., Ogata, T., Kanehiro, A., Ozaki, S., Fuchimoto, Y., Ogura, S., Yoshida, K., Beppu, S., Fukuyama, S., Eriguchi, Y., Yonekawa, A., Inoue, Y., Yamagata, K., Chiba, S., Narumoto, O., Nagai, H., Ooshima, N., Motegi, M., Sagara, H., Tanaka, A., Ohta, S., Shibata, Y., Tanino, Y., Sato, Y., Yamada, Y., Hashino, T., Shinoki, M., Iwagoe, H., Imamura, T., Umeda, A., Shimada, H., Endo, M., Hayashi, S., Nakano, S., Yatomi, M., Maeno, T., Ishii, T., Utsugi, M., Ono, A., Kanaoka, K., Ihara, S., Komuta, K., Boezen, M., Claringbould, A., Lopera, E., Warmerdam, R., Vonk, J.M., van Blokland, I., Lanting, P., Ori, APS, Obeidat, M., Hernández Cordero, A.I., Sin, D.D., Bossé, Y., Joubert, P., Hao, K., Nickle, D., Timens, W., van den Berge, M., Feng, Y.A., Mercader, J., Weiss, S.T., Karlson, E.W., Smoller, J.W., Murphy, S.N., Meigs, J.B., Woolley, A.E., Green, R.C., Perez, E.F., Zöllner, S., Wang, J., Beck, A., Sloofman, L.G., Ascolillo, S., Sebra, R.P., Collins, B.L., Levy, T., Sealfon, S.C., Jordan, D.M., Thompson, R.C., Gettler, K., Chaudhary, K., Belbin, G.M., Preuss, M., Hoggart, C., Choi, S., Underwood, S.J., Salib, I., Britvan, B., Keller, K., Tang, L., Peruggia, M., Hiester, L.L., Niblo, K., Aksentijevich, A., Labkowsky, A., Karp, A., Zlatopolsky, M., Zyndorf, M., Charney, A.W., Beckmann, N.D., Schadt, E.E., Abul-Husn, N.S., Cho, J.H., Itan, Y., Kenny, E.E., Loos, RJF, Nadkarni, G.N., Do, R., O'Reilly, P., Huckins, L.M., Ferreira, MAR, Abecasis, G.R., Leader, J.B., Cantor, M.N., Justice, A.E., Carey, D.J., Chittoor, G., Josyula, N.S., Kosmicki, J.A., Horowitz, J.E., Baras, A., Gass, M.C., Yadav, A., Mirshahi, T., Jan Hottenga, J., Bartels, M., de Geus, EJC, Nivard, M.G., Verma, A., Ritchie, M.D., Rader, D., Li, B., Verma, S.S., Lucas, A., Bradford, Y., Zara, F., Salpietro, V., Scala, M., Iacomino, M., Scudieri, P., Bocciardi, R., Minetti, C., Vari, M.S., Rahier, J.F., Giorgio, E., Carli, D., Louis, E., Bulik, C.M., Landén, M., Brusco, A., Ferrero, G.B., Madia, F., Fundín, B., Ismail, S.I., Saad, C., Al-Sarraj, Y., Badji, R.M., Al-Muftah, W., Al Thani, A., Afifi, N., Klovins, J., Rovite, V., Rescenko, R., Peculis, R., Ustinova, M., Zeberg, H., Frithiof, R., Hultström, M., Lipcsey, M., Johnson, R., Geschwind, D.H., Freimer, N., Butte, M.J., Ding, Y., Chiu, A., Chang, T.S., Boutros, P., Moutsianas, L., Caulfield, M.J., Scott, R.H., Walker, S., Stuckey, A., Odhams, C.A., Rhodes, D., Fowler, T., Rendon, A., Chan, G., Arumugam, P., Karczewski, K.J., Wilson, D.J., Spencer, C.A., Crook, D.W., Wyllie, D.H., O'Connell, A.M., Atkinson, E.G., Tsuo, K., Baya, N., Turley, P., Gupta, R., Walters, R.K., Palmer, D.S., Sarma, G., Cheng, N., Lu, W., Churchhouse, C., Goldstein, J.I., King, D., Seed, C., Daly, M.J., Bryant, S., Satterstrom, F.K., Band, G., Earle, S.G., Lin, S.K., Arning, N., Armstrong, J., Rudkin, J.K., Callier, S., Cusick, C., Soranzo, N., Zhao, J.H., Danesh, J., Di Angelantonio, E., Butterworth, A.S., Sun, Y.V., Huffman, J.E., Cho, K., O'Donnell, C.J., Tsao, P., Gaziano, J.M., Peloso, G., Ho, Y.L., Mian, M., Scaggiante, F., Chang, X., Glessner, J.R., Hakonarson, H., McGuigan, P.J., Prockter Moore, L.S., Vizcaychipi, M.P., Hall, K., Campbell, A., Nichol, A., Ward, G., Page, V.J., Semple, M.G., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Aldera, E.L., Alegria, A., Angus, B., Ashish, A., Atkinson, D., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Basude, S., Baxter, D., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Chadwick, D., Brittain-Long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chambler, D., Chee, N., Child, J., Chukkambotla, S., Clark, T., Collini, P., Cosgrove, C., Cupitt, J., Cutino-Moguel, M.T., Dark, P., Dawson, C., Dervisevic, S., Donnison, P., Douthwaite, S., Drummond, A., DuRand, I., Dushianthan, A., Dyer, T., Evans, C., Eziefula, C., Fegan, C., Finn, A., Fullerton, D., Garg, S., Garg, A., Gkrania-Klotsas, E., Godden, J., Goldsmith, A., Graham, C., Hardy, E., Hartshorn, S., Harvey, D., Havalda, P., Hawcutt, D.B., Hobrok, M., Hodgson, L., Hormis, A., Jacobs, M., Jain, S., Jennings, P., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kendall, J., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Laha, S., Laird, S., Larkin, S., Leiner, T., Lillie, P., Limb, J., Linnett, V., Little, J., Lyttle, M., MacMahon, M., MacNaughton, E., Mankregod, R., Masson, H., Matovu, E., McCullough, K., McEwen, R., Meda, M., Mills, G.H., Minton, J., Ward, K., Mirfenderesky, M., Mohandas, K., Mok, Q., Moon, J., Moore, E., Morgan, P., Morris, C., Mortimore, K., Moses, S., Mpenge, M., Mulla, R., Murphy, M., Nagel, M., Nagarajan, T., Nelson, M., O'Shea, M.K., Otahal, I., Ostermann, M., Pais, M., Panchatsharam, S., Papakonstantinou, D., Paraiso, H., Patel, B., Pattison, N., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J.S., Post, F., Price, D., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Roberts, M., Roberts, D., Rose, A., Rousseau, G., Ryan, B., Saluja, T., Shah, A., Shanmuga, P., Sharma, A., Shawcross, A., Sizer, J., Shankar-Hari, M., Smith, R., Snelson, C., Spittle, N., Staines, N., Stambach, T., Stewart, R., Subudhi, P., Szakmany, T., Tatham, K., Thomas, J., Thompson, C., Thompson, R., Tridente, A., Tupper-Carey, D., Twagira, M., Ustianowski, A., Vallotton, N., Vincent-Smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Walden, A., Welters, I., Whitehouse, T., Whittaker, P., Whittington, A., Papineni, P., Wijesinghe, M., Williams, M., Wilson, L., Cole, S., Winchester, S., Wiselka, M., Wolverson, A., Wooton, D.G., Workman, A., Yates, B., Young, P., Beale, R., Bretherick, A.D., Clohisey, S., Fourman, M.H., Furniss, J., Gountouna, E., Grimes, G., Haley, C., Harrison, D., Hayward, C., Keating, S., Klaric, L., Klenerman, P., Law, A., Meynert, A.M., Millar, J., Pairo-Castineira, E., Parkinson, N., Ponting, C.P., Porteous, D.J., Rawlik, K., Richmond, A., Rowan, K., Russell, C.D., Shen, X., Shih, B., Tenesa, A., Vitart, V., Wang, B., Wilson, J.F., Wu, Y., Yang, J., Yang, Z., Zechner, M., Zhai, R., Zheng, C., Norman, L., Pius, R., Drake, T.M., Fairfield, C.J., Knight, S.R., Mclean, K.A., Murphy, D., Shaw, C.A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Jackson, C., Gamble, C., Leeming, G., Wham, M., Hendry, R., Scott-Brown, J., Begg, C., Hinds, C., Wai Ho, A.Y., Horby, P.W., Knight, J., Ling, L., Maslove, D., McAuley, D., Montgomery, H., Openshaw, PJM, Summers, C., Walsh, T., Armstrong, L., Bates, H., Dooks, E., Farquhar, F., Hairsine, B., McParland, C., Packham, S., Alldis, Z., Astin-Chamberlain, R., Bibi, F., Biddle, J., Blow, S., Bolton, M., Borra, C., Bowles, R., Burton, M., Choudhury, Y., Collier, D., Cox, A., Easthope, A., Ebano, P., Fotiadis, S., Gurasashvili, J., Halls, R., Hartridge, P., Kallon, D., Kassam, J., Lancoma-Malcolm, I., Matharu, M., May, P., Mitchelmore, O., Newman, T., Patel, M., Pheby, J., Pinzuti, I., Prime, Z., Prysyazhna, O., Shiel, J., Taylor, M., Tierney, C., Wood, S., Zak, A., Zongo, O., Forsey, M., Nicholson, A., Riches, J., Vertue, M., Wasson, C., Finn, S., Green, J., Collins, E., King, B., Grauslyte, L., Hussain, M., Pogreban, T., Rosaroso, L., Salciute, E., Franke, G., Wong, J., George, A., Akeroyd, L., Bano, S., Bromley, M., Gurr, L., Lawton, T., Morgan, J., Sellick, K., Warren, D., Wilkinson, B., McGowan, J., Ledgard, C., Stacey, A., Pye, K., Bellwood, R., Bentley, M., Loosley, R., McGuinness, H., Tench, H., Wolf-Roberts, R., Gibson, S., Lyle, A., McNeela, F., Radhakrishnan, J., Hughes, A., Ali, A., Brady, M., Dale, S., Dance, A., Gledhill, L., Greig, J., Hanson, K., Holdroyd, K., Home, M., Kelly, D., Kitson, R., Matapure, L., Melia, D., Mellor, S., Nortcliffe, T., Pinnell, J., Robinson, M., Shaw, L., Shaw, R., Thomis, L., Wilson, A., Wood, T., Bayo, L.A., Merwaha, E., Ishaq, T., Hanley, S., Antcliffe, D., Banach, D., Brett, S., Coghlan, P., Fernandez, Z., Gordon, A., Rojo, R., Arias, S.S., Templeton, M., Jha, R., Krishnamurthy, V., Lim, L., Bi, R., Scholefield, B., Ashton, L., Williams, A., Cheyne, C., Saunderson, A., Allan, A., Anderson, F., Kaye, C., Liew, J., Medhora, J., Scott, T., Trumper, E., Botello, A., Polgarova, P., Stroud, K., Meaney, E., Jones, M., Ng, A., Agrawal, S., Pathan, N., White, D., Daubney, E., Elston, K., Parker, R., Reddy, A., Turner-Bone, I., Wilding, L., Harding, P., Jacob, R., Jones, C., Denmade, C., Croft, M., White, I., Griffin, D., Muchenje, N., Mupudzi, M., Partridge, R., Conyngham, J.A., Thomas, R., Wright, M., Corral, M.A., Bastion, V., Clarke, D., David, B., Kent, H., Lorusso, R., Lubimbi, G., Murdoch, S., Penacerrada, M., Thomas, A., Valentine, J., Vochin, A., Wulandari, R., Djeugam, B., Dawson, J., Garrioch, S., Tolson, M., Aldridge, J., de Almeida Martins, L.G., Carungcong, J., Beavis, S., Dale, K., Gascoyne, R., Hawes, J., Pritchard, K., Stevenson, L., Whileman, A., Cowley, A., Highgate, J., Crawley, R., Crew, A., Cunningham, M., Daniels, A., Harrison, L., Hope, S., Inweregbu, K., Jones, S., Lancaster, N., Matthews, J., Wray, G., Benham, L., Bradshaw, Z., Brown, J., Caswell, M., Melling, S., Preston, S., Slawson, N., Stoddard, E., Warden, S., Combes, E., Joefield, T., Monnery, S., Beech, V., Trotman, S., Hopkins, B., Scriven, J., Thrasyvoulou, L., Willis, H., Anderson, S., Birch, J., Hammerton, K., O'Leary, R., Abernathy, C., Foster, L., Gratrix, A., Martinson, V., Parkinson, P., Stones, E., Carbral-Ortega, L., Kapoor, R., Loader, D., Castle, K., Brandwood, C., Smith, L., Clark, R., Birchall, K., Kolakaluri, L., Baines, D., Sukumaran, A., Mapfunde, I., Meredith, M., Morris, L., Ryan, L., Clark, A., Sampson, J., Peters, C., Dent, M., Langley, M., Wei, S., Andrew, A., Chablani, M., Kirkby, A., Netherton, K., Bates, M., Dasgin, J., Gill, J., Nilsson, A., Apetri, E., Basikolo, C., Blackledge, B., Catlow, L., Charles, B., Doonan, R., Harris, J., Harvey, A., Horner, D., Knowles, K., Lomas, D., Lyons, C., Marsden, T., McLaughlan, D., McMorrow, L., Pendlebury, J., Perez, J., Poulaka, M., Proudfoot, N., Slaughter, M., Slevin, K., Thomas, V., Walker, D., Michael, A., Collis, M., Clark, M., Coulding, M., Jude, E., McCormick, J., Mercer, O., Potla, D., Rehman, H., Savill, H., Turner, V., Davey, M., Golden, D., Seaman, R., Hunt, J., Dearden, J., Dobson, E., Mulcahy, M., Munt, S., O'Connor, G., Philbin, J., Rishton, C., Tully, R., Winnard, S., Cagova, L., Fofano, A., Garner, L., Holcombe, H., Mepham, S., Mitchell, A.M., Mwaura, L., Zamikula, J., Bercades, G., Brealey, D., Hass, I., MacCallum, N., Martir, G., Raith, E., Reyes, A., Smyth, D., Taylor, A., Hughes, R.A., Thomas, H., Rees, A., Duskova, M., Phipps, J., Brooks, S., Edwards, M., Alexander, P., Allen, S., Bradley-Potts, J., Brantwood, C., Egan, J., Felton, T., Padden, G., Ward, L., Moss, S., Glasgow, S., Beesley, K., Board, S., Kubisz-Pudelko, A., Lewis, A., Perry, J., Pippard, L., Wood, D., Buckley, C., Brown, A., Gregory, J., O'Connell, S., Smith, T., Belagodu, Z., Fuller, B., Gherman, A., Olufuwa, O., Paramsothy, R., Stuart, C., Oakley, N., Kamundi, C., Tyl, D., Collins, K., Silva, P., Taylor, J., King, L., Coates, C., Crowley, M., Wakefield, P., Beadle, J., Johnson, L., Sargeant, J., Anderson, M., Jardine, C., Williams, D., Parris, V., Quaid, S., Watson, E., 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Burt, K., Spivey, M., Eastgate-Jackson, C., Filipe, H., Martin, D., Maharajh, A., Garcia, S.M., De Neef, M., Lynch, C., Howe, G.S., Singh, J., Turner, K., Ellis, H., Stroud, N., Cherian, S., Cutler, S., Heron, A.E., Roynon-Reed, A., Williams, G., Richards, O., Cheema, Y., Ahmad, N., Barker, J., Bauchmuller, K., Bird, S., Cawthron, K., Harrington, K., Jackson, Y., Kibutu, F., Lenagh, B., Masuko, S., Raithatha, A., Wiles, M., Willson, J., Newell, H., Lye, A., Nwafor, L., Jarman, C., Rowland-Jones, S., Foote, D., Cole, J., Watson, J., Hesseldon, L., Macharia, I., Chetam, L., Ford, A., Housley, K., Milner, L., Hanratty, H., Trower, H., Phillips, P., Oxspring, S., Donne, B., Bevan, E., Martin, J., Trodd, D., Watson, G., Brown, C.W., Bunni, L., Jennings, C., Latif, M., Marshall, R., Subramanian, G., Bandla, N., Gellamucho, M., Davies, M., Trim, F., Eapen, B., Ahmed, C., Baines, B., Clamp, S., Colley, J., Haq, R., Hayes, A., Hulme, J., Joseph, S., Kumar, R., Maqsood, Z., Purewal, M., 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Reid, K., Imeson-Wood, J., Bellini, A., Bryant, J., Pickard, A., Roe, N., Sowter, J., Howlett, A., Criste, K., Cusack, R., Golder, K., Golding, H., Jones, O., Leggett, S., Male, M., Marani, M., Prager, K., Williams, T., Roberts, B., Salmon, K., Gondo, P., Kayani, A., Masunda, B., Ahmed, A., Morris, A., Jakkula, S., Long, K., Whiteley, S., Wilby, E., Ogg, B., Moultrie, S., Bewley, J., Garland, Z., Grimmer, L., Gumbrill, B., Sweet, K., Webster, D., Efford, G., Bennett, S., Goodwin, E., Jackson, M., Kent, A., Tibke, C., Woodyatt, W., Zaki, A., Daniel, A., Finn, J., Bremmer, P., Houston, G., O'Brien, P., Bell, D., Boyle, R., Douglas, K., Glass, L., Lee, E., Lennon, L., Rattray, A., Charnock, R., McFarland, D., Cosgrove, D., Attwood, B., Parsons, P., Carmody, S., Oblak, M., Popescu, M., Thankachen, M., Baruah, R., Morris, S., Ferguson, S., Shepherd, A., Altabaibeh, A., Alvaro, A., Gilbert, K., Ma, L., Mostoles, L., Parmar, C., Jetha, C., Booker, L., Pratley, A., Cosier, T., Millen, G., Schumacher, N., Weston, H., Rand, J., Alex, B., Bach, B., Barclay, W.S., Bogaert, D., Chand, M., Cooke, G.S., Docherty, A.B., Dunning, J., da Silva Filipe, A., Fletcher, T., Green, C.A., Harrison, E.M., Hiscox, J.A., Ijaz, S., Khoo, S., Lim, W.S., Mentzer, A.J., Merson, L., Noursadeghi, M., Moore, S.C., Palmarini, M., Paxton, W.A., Pollakis, G., Price, N., Rambaut, A., Robertson, D.L., Sancho-Shimizu, V., Scott, J.T., de Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Tedder, R.S., Thomson, E.C., Roger Thompson, A.A., Thwaites, R.S., Turtle, LCW, Gupta, R.K., Palmieri, C., Swann, O.V., Zambon, M., Dumas, M.E., Griffin, J.L., Takats, Z., Chechi, K., Andrikopoulos, P., Osagie, A., Olanipekun, M., Liggi, S., Lewis, M.R., Correia, GDS, Sands, C.J., Takis, P., Maslen, L., Greenhalf, W., Shaw, V., McDonald, S.E., Ahmed, K.A., Armstrong, J.A., Ashworth, M., Asiimwe, I.G., Bakshi, S., Barlow, S.L., Booth, L., Brennan, B., Bullock, K., Catterall, BWA, Clark, J.J., Clarke, E.A., Cox, H., Dincarslan, O., Dunn, C., Dyer, P., Elliott, A., Evans, A., Finch, L., Fisher, LWS, Foster, T., Garcia-Dorival, I., Gunning, P., Hartley, C., Jensen, R.L., Jones, C.B., Jones, T.R., Khandaker, S., Kiy, R.T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-Langham, L., Lefteri, D., Lett, L., Livoti, L.A., Mancini, M., McDonald, S., McEvoy, L., McLauchlan, J., Metelmann, S., Miah, N.S., Middleton, J., Mitchell, J., Murphy, E.G., Penrice-Randal, R., Pilgrim, J., Prince, T., Reynolds, W., Ridley, P.M., Sales, D., Shaw, V.E., Shears, R.K., Small, B., Subramaniam, K.S., Szemiel, A., Taggart, A., Tanianis-Hughes, J., Trochu, E., van Tonder, L., Wilcock, E., Zhang, J.E., Flaherty, L., Maziere, N., Cass, E., Carracedo, A.D., Carlucci, N., Holmes, A., Massey, H., Murphy, L., Wrobel, N., McCafferty, S., Morrice, K., MacLean, A., Armstrong, R., Boz, C., Coutts, A., Cullum, L., Day, N., Donnelly, L., Duncan, E., Fawkes, A., Finernan, P., Gilchrist, T., Golightly, A., Hafezi, K., Law, D., Law, R., Law, S., Macgillivray, L., Maclean, A., Mal, H., Mcmaster, E., Meikle, J., Oosthuyzen, W., Paterson, T., Stenhouse, A., Swets, M., Szoor-McElhinney, H., Taneski, F., Wackett, T., Ward, M., Weaver, J., Coyle, J., Gallagher, B., Lidstone-Scott, R., Hamilton, D., Schon, K., Furlong, A., Biggs, H., Griffiths, F., Andrews, E., Brickell, K., Smyth, M., Carson, G., Hardwick, H., Donohue, C., Neale, Benjamin M. [0000-0003-1513-6077], Apollo - University of Cambridge Repository, Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Guided Treatment in Optimal Selected Cancer Patients (GUTS), AII - Infectious diseases, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology, Infectious diseases, Center of Experimental and Molecular Medicine, APH - Aging & Later Life, APH - Global Health, APH - Quality of Care, Amsterdam institute for Infection and Immunity, APH - Health Behaviors & Chronic Diseases, Global Health, APH - Methodology, Graduate School, ACS - Heart failure & arrhythmias, Anesthesiology, ACS - Diabetes & metabolism, APH - Digital Health, APH - Personalized Medicine, ACS - Microcirculation, Niemi, M. E. K., Liao, R. G., Neale, B. M., Pathak, G. A., Andrews, S. J., Schulte, E. C., Karim, M. A., Wendt, F. R., Kim, H. -N., Uddin, M. J., Smith, G. D., Willer, C. J., Buxbaum, J. D., Martin, A. R., Balaconis, M. K., Sankaran, V. G., Brent Richards, J., Eric Kerchberger, V., Kenneth Baillie, J., Dutta, A. K., Uddin, M. M., Perez-Tur, J., Verdugo, R. A., Zarate, R., Medina-Gomez, C., Gomez-Cabrero, D., Cadilla, C. L., Boua, P. R., Fave, M. -J., Lemacon, A., Szentpeteri, J. L., Ahmad, H. F., Kornilov, S. A., Prokic, I., Pearson, N. M., Shelton, J. F., Shastri, A. J., Weldon, C. H., Brouwer, M. C., Vlaar, A. P. J., Joost Wiersinga, W., Algera, A. G., Bogaard, H. J., Bonta, P. I., Grobusch, M. P., Hermans, S. M., Hovius, J. W., de Jong, M. D., Nossent, E. J., Prins, J. M., Schultz, M. J., Stijnis, C. S., Minnaar, R. P., van Uffelen, K. W. J., Wolterman, R. A., Ball, C. A., Mccurdy, S., Hong, E. L., Baltzell, A. H., Goffard, J. -C., Peree, H., Leonard, P., Giot, J. -B., Sauvage, A. -S., Wery, M., Morrison, D. R., Chasse, M., Kaufmann, D. E., Mark Lathrop, G., Davis, L. K., Cox, N. J., Below, J. E., Sealock, J. M., Faucon, A. B., Shuey, M. M., Polikowsky, H. G., Petty, L. E., Shaw, D. M., Chen, H. -H., Ludwig, K. U., Schroder, J., Nothen, M. M., Jensen, B. -E. O., Altmuller, J., Berger, M. M., Gogele, M., Gignoux, C. R., Wicks, S. J., Barnes, K. C., Goldstein, D. B., Reilly, M. P., Gharavi, A. G., O'Byrne, S. M., So, Y. S., Park, S. -K., Kim, H. -L., Kang, C. K., Lee, H. -J., Song, K. -H., Yoon, K. J., Paik, N. -J., Joo, E. -J., Park, W. B., Park, J. S., Park, K. U., Ham, S. Y., Kim, E. S., Kim, H. B., Caceres, M., Lenz, T. L., Julia, A., Holter, J. C., Fernandez, J., Sander, L. E., Banales, J. M., Romero-Gomez, M., Hov, J. R., Karlsen, T. H., Wacker, E. M., Elabd, H., Ruhlemann, M. C., Vadla, M. S., Lenning, O. B., Ozer, O., Kassens, J., Figuera Basso, M. E., Ortiz, A. B., Chercoles, A. G., Holten, A. R., Kildal, A. B., Gluck, A., Nolla, A. C., Dyrhol-Riise, A. M., Spinner, C. D., Hoff, D. A. L., Jimenez, D., Pestana, D., Helbig, E. T., Paraboschi, E. M., Sanchez, F. G., Hernandez, I., Galvan-Femenia, I., Badia, J. R., Muller, K. E., Gaede, K. I., Lippert, L. J., Tellez, L., Gutierrez-Stampa, M. A., Vehreschild, M. J. G. T., Marquie, M., Seilmaier, M. J., Rodriguez-Gandia, M., Ayo, N. I., Martinez, N., Cornely, O. A., Rodrigues, P. M., Espana, P. P., Garcia-Fernandez, A. -E., Fracanzani, A. L., Muniz-Diaz, E., Calderon, E. J., Solligard, E., Medrano, F. J., Muller, F., Afset, J. E., Damas, J. K., Ferrusquia-Acosta, J., Quero, J. H., Guerrero, J. M., Bettini, L. R., Gustad, L. T., Valsecchi, M. G., D'Angio, M., Gallego-Duran, R., Cejudo, T. G., Grimsrud, M. M., Gudbjartsson, D. F., Moore, K. H. S., Alarcon-Riquelme, M. E., Martinez-Bueno, M., Rello, S. R., Lall, K., Bochud, P. -Y., Nussle, S. G., Meyer zu Bentrup, F., Merlet Viollet, R., Guery, B., Hugli, O., Gonseth Nussle, S., Estoppey Younes, S., Rochat Negro, T., Mercader, J. M., Castano-Vinyals, G., Dobano, C., Mondelli, M. U., Mazzei, M. A., Caldarelli, G. P., Monforte, A. D., Scotton, P. G., Monica, M. D., Mandala, M., Coviello, D. A., La Rovere, M. T., Segala, F. V., Mencarelli, M. A., Pinto, A. M., Carriero, M. L., Ann Belli, M., Antoni, M. D., Miraglia, F. G., Parisi, S. G., Squeo, G. M., Botta, G., Hunt, K. A., Trembath, R. C., Martin, H. C., Griffiths, C. J., Curtis, C. J., Huang, Q. Q., Lee, S. H., Macarthur, D., Maclaughlin, B., Smith, A. V., Boughton, A. P., Li, K. W., Lefaive, J., Jannes, C. E., Krieger, J. E., Pereira, A. C., Lima, I. R., Tada, M. T., Mccarthy, M., Lee, J. E., Lee, H. S., Jang, H. Y., Kim, Y. -S., Kwon, K. T., Kim, S. -W., Kim, J. Y., Jang, Y. R., Kim, H., Lee, J. Y., Choe, K. -W., Kang, Y. M., Jee, S. H., Jung, K. J., Schroth, G. P., Desouza, F., Cirulli, E. T., Schiabor Barrett, K. M., Washington, N. L., Lu, J. T., Ramirez, J. M., Grzymski, J. J., Minano, J. I. E., Aguirre, L. A., Lopez-Collazo, E., Lozano-Rodriguez, R., Avendano-Ortiz, J., Arcos, V. T., Montalban-Hernandez, K. M., Quiroga, J. V., Martin-Quiros, A., Nakada, T. -A., Vonk, J. M., Ori, A. P. S., Hernandez Cordero, A. I., Sin, D. D., Bosse, Y., Feng, Y. -C. A., Weiss, S. T., Karlson, E. W., Smoller, J. W., Murphy, S. N., Meigs, J. B., Woolley, A. E., Green, R. C., Perez, E. F., Zollner, S., Sloofman, L. G., Sebra, R. P., Collins, B. L., Sealfon, S. C., Jordan, D. M., Thompson, R. C., Belbin, G. M., Underwood, S. J., Hiester, L. L., Charney, A. W., Beckmann, N. D., Schadt, E. E., Abul-Husn, N. S., Cho, J. H., Kenny, E. E., Loos, R. J. F., Nadkarni, G. N., Huckins, L. M., Ferreira, M. A. R., Abecasis, G. R., Leader, J. B., Cantor, M. N., Justice, A. E., Carey, D. J., Josyula, N. S., Kosmicki, J. A., Horowitz, J. E., Gass, M. C., Hottenga, J. J., de Geus, E. J. C., Nivard, M. G., Ritchie, M. D., Verma, S. S., Vari, M. S., Rahier, J. -F., Bulik, C. M., Landen, M., Ferrero, G. B., Fundin, B., Ismail, S. I., Badji, R. M., Hultstrom, M., Geschwind, D. H., Butte, M. J., Chang, T. S., Caulfield, M. J., Scott, R. H., Odhams, C. A., Karczewski, K. J., Wilson, D. J., Spencer, C. A., Crook, D. W., Wyllie, D. H., O'Connell, A. M., Atkinson, E. G., Walters, R. K., Palmer, D. S., Goldstein, J. I., Kyle Satterstrom, F., Earle, S. G., Lin, S. -K., Rudkin, J. K., Zhao, J. H., Butterworth, A. S., Sun, Y. V., Huffman, J. E., O'Donnell, C. J., Michael Gaziano, J., Ho, Y. -L., Glessner, J. R., Mcguigan, P. J., Moore, L. S. P., Vizcaychipi, M. P., Page, V. J., Aldera, E. L., Cutino-Moguel, M. -T., Durand, I., Hawcutt, D. B., Macmahon, M., Macnaughton, E., Mccullough, K., Mcewen, R., O'Shea, M. K., Pooni, J. S., Wooton, D. G., Bretherick, A. D., Fourman, M. H., Meynert, A. M., Ponting, C. P., Porteous, D. J., Russell, C. D., Wilson, J. F., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Shaw, C. A., Ho, A. Y. W., Horby, P. W., Mcauley, D., Openshaw, P. J. M., Semple, M. G., Mcgowan, J., Mcguinness, H., Mcneela, F., Bayo, L. -A., Arias, S. S., Conyngham, J. -A., Corral, M. A., de Almeida Martins, L. G., Mclaughlan, D., Mcmorrow, L., Mccormick, J., Mitchell, A. M., Maccallum, N., Hughes, R. A., Jones, T. O., Mcphail, M., Mckenley, I., Sutherland, S. -B., de Gordoa, L. O. -R., Gude, E. T., Macgoey, P., Mckenna, E., Patel, B. V., Zborowski, A. C., Garcia, S. M., Howe, G. S., Heron, A. E., Mills, G. H., Brown, C. W., Akhtar, M. N., Delgado, C. C., Saluzzio, R. P., Da Gloria, E. F., Hurt, W. J., Wood, H. -L., Mcalindon, M., Mccurdy, A., Ali, I. A. M., Ally, S. M., Hamilton, D. O., Lopez Martinez, M., Waite, A. A. C., Welters, I. D., Rosa, A. D., Baikady, R. R., Tatham, K. C., Beith, C. M., Mcgregor, A., Mcivor, S., Allison, K. S., Jones, G. A. L., Mchugh, T., Peters, M. J., Tomas, A. L., Mckechnie, S., Mccormack, L., Michael, H. T., Durrans, L. J., Suarez, J. C., Death, Y., Mccormick, W., Mccreath, G., Rai, S. G., Mcculloch, C., Mcfarland, D., Barclay, W. S., Cooke, G. S., Docherty, A. B., Green, C. A., Harrison, E. M., Hiscox, J. A., Lim, W. S., Mentzer, A. J., Paxton, W. A., Robertson, D. L., Scott, J. T., Tedder, R. S., Thomson, E. C., Thwaites, R. S., Gupta, R. K., Swann, O. V., Dumas, M. -E., Griffin, J. L., Lewis, M. R., dos Santos Correia, G., Sands, C. J., Mcdonald, S. E., Ahmed, K. A., Armstrong, J. A., Asiimwe, I. G., Barlow, S. L., Catterall, B. W. A., Clark, J. J., Clarke, E. A., Fisher, L. W. S., Jensen, R. L., Jones, C. B., Jones, T. R., Kiy, R. T., Livoti, L. A., Mcdonald, S., Mcevoy, L., Mclauchlan, J., Miah, N. S., Moore, S. C., Murphy, E. G., Matthew Ridley, P., Shaw, V. E., Shears, R. K., Subramaniam, K. S., Eunice Zhang, J., Carracedo, A. D., Mccafferty, S., Turtle, L. C. W., Data Science Genetic Epidemiology Lab, Institute for Molecular Medicine Finland, HUS Helsinki and Uusimaa Hospital District, University of Helsinki, Research Programs Unit, Doctoral Programme in Population Health, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, and University of Zurich
Subjects: Male, 45/43, Autoimmunity, Autoimmunity/genetics, Body Mass Index, COVID-19/genetics, COVID-19/virology, Critical Illness, Female, Genetic Loci/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Geographic Mapping, Hospitalization, Host-Pathogen Interactions/genetics, Humans, Inflammation/complications, Information Dissemination, Multifactorial Inheritance, Racial Groups/genetics, SARS-CoV-2/pathogenicity, Smoking, environmental risk factors, Q1, 631/208, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genetics, Genome-wide association studies, SARS-CoV-2, Viral infection, GWAS, Aetiology, Lung, QC, 0303 health sciences, HERITABILITY, 3. Good health, covid-19, Science & Technology - Other Topics, Identification (biology), Infection, Human, 631/208/205/2138, Settore BIO/11 - Biologia Molecolare, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Clinical Research, Biodefense, Genetics, GENOME-WIDE ASSOCIATION, Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714 [VDP], METAANALYSIS, 1000 Multidisciplinary, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, Prevention, Racial Groups, Pneumonia, genetic architecture, Human genetics, Genetic Loci, genetic factors, 570 Life sciences, biology, 030217 neurology & neurosurgery, Medizin, Infektionsmedicin, Genome-wide association studies, Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, Pandemic, 2.1 Biological and endogenous factors, pandemi, Multidisciplinary, article, Public Health, Global Health, Social Medicine and Epidemiology, Racial Group, 10124 Institute of Molecular Life Sciences, Host-Pathogen Interaction, Multidisciplinary Sciences, Infectious Diseases, Host-Pathogen Interactions, Critical Illne, COVID-19, GWAS, genetic factors, environmental risk factors, therapy, Infectious Medicine, Coronavirus disease 2019 (COVID-19), SUSCEPTIBILITY LOCI, General Science & Technology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Computational biology, Biology, Vaccine Related, 692/699/255/2514, Environmental risk, Mendelian randomization, COVID-19 Host Genetics Initiative, QH426, 631/326/596/4130, 030304 developmental biology, Inflammation, therapy, SARS-CoV-2, Human Genome, COVID-19, Genetic architecture, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Emerging Infectious Diseases, Good Health and Well Being, Viral infection, 3111 Biomedicine
Abstract: Niemi, Mari E. K. et al. 39 páginas, figuras y tablas. Contiene material suplementario., The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3-7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
Published: 2021

19. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author: Farid Radmanesh, Kenneth Rice, Xiuqing Guo, Jessica van Setten, Konstantin Strauch, Albert V. Smith, Jeffrey Haessler, Stefan Kääb, Folkert W. Asselbergs, Patricia B. Munroe, Steven A. Lubitz, Ching-Ti Liu, Niek Verweij, Aaron Isaacs, Martina Müller-Nurasyid, Allan Linneberg, Jan A. Kors, Ozren Polasek, Kari Stefansson, Caroline Hayward, Daniel F. Gudbjartsson, Jonathan Marten, Olli T. Raitakari, Mark Eijgelsheim, Timothy J. Mead, Nona Sotoodehnia, Elsayed Z. Soliman, Hao Mei, Gianfranco Sinagra, Stefan Weiss, Torben Hansen, Michiel L. Bots, Mika Kähönen, Yalda Jamshidi, Xiaoqin Liu, Stefania Cappellani, Unnur Thorsteinsdottir, Nilesh J. Samani, Cecilia W. Lo, Honghuang Lin, Charles Kooperberg, Moritz F. Sinner, Zhijun Xie, Jennifer A. Brody, Paolo Gasparini, Ruifang Li-Gao, Leo-Pekka Lyytikäinen, Stefan van Duijvenboden, Nikolai Klena, Michele Orini, Stella Trompet, Joop Jukema, Tamara B. Harris, Jerome I. Rotter, Stephan B. Felix, Julia Ramirez, Sheila Ulivi, Ioanna Ntalla, Marcus Dörr, Annette Peters, Paul L. Huang, Dennis O. Mook-Kanamori, Igor Rudan, Cornelia M. van Duijn, Christopher P. Nelson, Anna F. Dominiczak, Henry Völzke, Terho Lehtimäki, Niels Grarup, Henry J. Lin, Bruno H. Stricker, Tim D. Spector, Molly Schwartz, Patrick T. Ellinor, Vilmundur Gudnason, Uwe Völker, Christopher Newton-Cheh, Antonietta Robino, Marten E. van den Berg, Çağrı Güleç, Marco V Perez, Jette Bork-Jensen, Pim van der Harst, Rudolf A. de Boer, Jonathan Rosand, Oluf Pedersen, Susan R. Heckbert, David O Arnar, Dan E. Arking, André G. Uitterlinden, Andrew Tinker, Bram P. Prins, Lenore J. Launer, Alvaro Alonso, Leanne M. Hall, Helen R. Warren, Man Li, Pier D. Lambiase, Jørgen K. Kanters, Ilonca Vaartjes, James G. Wilson, Sandosh Padmanabhan, Melanie Waldenberger, Nathan A. Bihlmeyer, Peter van der Meer, Francesco J. Conti, George C. Gabriel, Hilma Holm, Gardar Sveinbjornsson, Suneel S. Apte, Annamaria Iorio, Blair H. Smith, Bruce M. Psaty, RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, RS: CARIM - R1.01 - Blood proteins & engineering, RS: FHML MaCSBio, Biochemie, Jamshidi, Yalda [0000-0003-0151-6482], Apollo - University of Cambridge Repository, Medical Informatics, Epidemiology, Internal Medicine, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), School of Engineering and Natural Sciences (UI), Verkfræði- og náttúruvísindasvið (HÍ), Háskóli Íslands (HÍ), University of Iceland (UI), Prins, Bram P, Mead, Timothy J, Brody, Jennifer A, Sveinbjornsson, Gardar, Ntalla, Ioanna, Bihlmeyer, Nathan A, van den Berg, Marten, Bork-Jensen, Jette, Cappellani, Stefania, Van Duijvenboden, Stefan, Klena, Nikolai T, Gabriel, George C, Liu, Xiaoqin, Gulec, Cagri, Grarup, Niel, Haessler, Jeffrey, Hall, Leanne M, Iorio, Annamaria, Isaacs, Aaron, Li-Gao, Ruifang, Lin, Honghuang, Liu, Ching-Ti, Lyytikäinen, Leo-Pekka, Marten, Jonathan, Mei, Hao, Müller-Nurasyid, Martina, Orini, Michele, Padmanabhan, Sandosh, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, van Setten, Jessica, Smith, Albert V, Verweij, Niek, Warren, Helen R, Weiss, Stefan, Alonso, Alvaro, Arnar, David O, Bots, Michiel L, de Boer, Rudolf A, Dominiczak, Anna F, Eijgelsheim, Mark, Ellinor, Patrick T, Guo, Xiuqing, Felix, Stephan B, Harris, Tamara B, Hayward, Caroline, Heckbert, Susan R, Huang, Paul L, Jukema, J W, Kähönen, Mika, Kors, Jan A, Lambiase, Pier D, Launer, Lenore J, Li, Man, Linneberg, Allan, Nelson, Christopher P, Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce M, Raitakari, Olli T, Rice, Kenneth M, Rotter, Jerome I, Sinner, Moritz F, Soliman, Elsayed Z, Spector, Tim D, Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Vaartjes, Ilonca, van der Meer, Peter, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Wilson, James G, Xie, Zhijun, Asselbergs, Folkert W, Dörr, Marcu, van Duijn, Cornelia M, Gasparini, Paolo, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hansen, Torben, Kääb, Stefan, Kanters, Jørgen K, Kooperberg, Charle, Lehtimäki, Terho, Lin, Henry J, Lubitz, Steven A, Mook-Kanamori, Dennis O, Conti, Francesco J, Newton-Cheh, Christopher H, Rosand, Jonathan, Rudan, Igor, Samani, Nilesh J, Sinagra, Gianfranco, Smith, Blair H, Holm, Hilma, Stricker, Bruno H, Ulivi, Sheila, Sotoodehnia, Nona, Apte, Suneel S, van der Harst, Pim, Stefansson, Kari, Munroe, Patricia B, Arking, Dan E, Lo, Cecilia W, Jamshidi, Yalda, Medical Biochemistry, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, AII - Infectious diseases, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, Amsterdam institute for Infection and Immunity, Amsterdam Gastroenterology Endocrinology Metabolism, Radiotherapy, Experimental Immunology, Gastroenterology and Hepatology, Graduate School, Intensive Care Medicine, Cardiology, Cardiovascular Centre (CVC), and Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Subjects: 0301 basic medicine, ADAMTS6, Conduction, Exome chip, Meta-analysis, Male, Gene Expression, Genome-wide association study, Sudden cardiac death, Electrocardiography, Mice, ADAMTS Proteins, PR INTERVAL, Exome, lcsh:QH301-705.5, Exome sequencing, POPULATION, education.field_of_study, Gen, Ecology, Adamts6, Exome Chip, COMMON VARIANTS, Middle Aged, cardiovascular system, Female, Electrical conduction system of the heart, QRS DURATION, lcsh:QH426-470, Evolution, Population, Black People, Computational biology, Biology, Polymorphism, Single Nucleotide, White People, WORSENING HEART-FAILURE, 03 medical and health sciences, QRS complex, Open Reading Frames, Behavior and Systematics, VENTRICULAR CONDUCTION, Heart Conduction System, Cardiac conduction, Exome Sequencing, medicine, Genetics, Erfðafræði, Animals, Humans, ARRHYTHMIC DEATH, cardiovascular diseases, GENOME-WIDE ASSOCIATION, education, Ecology, Evolution, Behavior and Systematics, Research, Gene Expression Profiling, Myocardium, MORTALITY, Rannsóknir, Cell Biology, medicine.disease, lcsh:Genetics, 030104 developmental biology, lcsh:Biology (General), Genetic Loci, Connexin 43, ELECTROCARDIOGRAPHIC PARAMETERS, Genome-Wide Association Study
Abstract: Publisher's version (útgefin grein)., Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear. Results: Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome BeadChip genotype data from 77,898 participants of European ancestry and 7695 of African descent in our discovery cohort, followed by replication in 111,874 individuals of European ancestry from the UK Biobank and deCODE cohorts. We identify ten novel loci, seven within coding regions, including ADAMTS6, significantly associated with QRS duration in gene-based analyses. ADAMTS6 encodes a secreted metalloprotease of currently unknown function. In vitro validation analysis shows that the QRS-associated variants lead to impaired ADAMTS6 secretion and loss-of function analysis in mice demonstrates a previously unappreciated role for ADAMTS6 in connexin 43 gap junction expression, which is essential for myocardial conduction. Conclusions: Our approach identifies novel coding and non-coding variants underlying ventricular depolarization and provides a possible mechanism for the ADAMTS6-associated conduction changes., Funding This work was funded by a grant to YJ from the British Heart Foundation (PG/12/38/29615). AGES: This study has been funded by NIH contracts N01-AG-1-2100 and 271201200022C, the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). The study is approved by the Icelandic National Bioethics Committee, VSN: 00–063. The researchers are indebted to the participants for their willingness to participate in the study. ARIC: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C), R01HL087641, R01HL59367, and R01HL086694; National Human Genome Research Institute contract U01HG004402; and National Institutes of Health contract HHSN268200625226C. The authors thank the staff and participants of the ARIC study for their important contributions. Infrastructure was partly supported by Grant Number UL1RR025005, a component of the National Institutes of Health and NIH Roadmap for Medical Research. Funding support for “Building on GWAS for NHLBI-diseases: the U.S. CHARGE consortium” was provided by the NIH through the American Recovery and Reinvestment Act of 2009 (ARRA) (5RC2HL102419). BRIGHT: The Exome Chip genotyping was funded by Wellcome Trust Strategic Awards (083948 and 085475). This work was also supported by the Medical Research Council of Great Britain (Grant no. G9521010D); and by the British Heart Foundation (Grant no. PG/02/128). AFD was supported by the British Heart Foundation (Grant nos. RG/07/005/23633 and SP/08/005/25115); and by the European Union Ingenious HyperCare Consortium: Integrated Genomics, Clinical Research, and Care in Hypertension (grant no. LSHM-C7–2006-037093). The BRIGHT study is extremely grateful to all the patients who participated in the study and the BRIGHT nursing team. We would also like to thank the Barts Genome Centre staff for their assistance with this project. CHS: This Cardiovascular Health Study (CHS) research was supported by NHLBI contracts HHSN268201800001C, HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086; and NHLBI grants R01HL068986, U01HL080295, R01HL087652, R01HL105756, R01HL103612, R01HL120393, and U01HL130114 with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided through R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR001881, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. ERF: The ERF study as a part of EUROSPAN (European Special Populations Research Network) was supported by European Commission FP6 STRP grant number 018947 (LSHG-CT-2006-01947) and also received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013)/grant agreement HEALTH-F4–2007-201413 by the European Commission under the programme “Quality of Life and Management of the Living Resources” of 5th Framework Programme (no. QLG2-CT-2002-01254). The ERF study was further supported by ENGAGE consortium and CMSB. High-throughput analysis of the ERF data was supported by joint grant from Netherlands Organization for Scientific Research and the Russian Foundation for Basic Research (NWO-RFBR 047.017.043). We are grateful to all study participants and their relatives, general practitioners, and neurologists for their contributions to the ERF study and to P Veraart for her help in genealogy, J Vergeer for the supervision of the laboratory work, and P Snijders for his help in data collection. FHS: The Framingham Heart Study (FHS) research reported in this article was supported by a grant from the National Heart, Lung, and Blood Institute (NHLBI), HL120393. Generation Scotland: Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Genotyping of the Generation Scotland and Scottish Family Health Study samples was carried out by the Genetics Core Laboratory at the Clinical Research Facility, Edinburgh, Scotland and was funded by the UK’s Medical Research Council. GOCHA: The Genetics of Cerebral Hemorrhage with Anticoagulation was carried out as a collaborative study supported by grants R01NS073344, R01NS059727, and 5K23NS059774 from the NIH–National Institute of Neurological Disorders and Stroke (NIH-NINDS). GRAPHIC: The GRAPHIC Study was funded by the British Heart Foundation (BHF/RG/2000004). NJS and CPN are supported by the British Heart Foundation and is a NIHR Senior Investigator. This work falls under the portfolio of research supported by the NIHR Leicester Cardiovascular Biomedical Research. INGI-FVG: This study has been funded by Regione FVG (L.26.2008). INTER99: The Inter99 was initiated by Torben Jørgensen (PI), Knut Borch-Johnsen (co-PI), Hans Ibsen and Troels F. Thomsen. The steering committee comprises the former two and Charlotta Pisinger. The study was financially supported by research grants from the Danish Research Council, the Danish Centre for Health Technology Assessment, Novo Nordisk Inc., Research Foundation of Copenhagen County, Ministry of Internal Affairs and Health, the Danish Heart Foundation, the Danish Pharmaceutical Association, the Augustinus Foundation, the Ib Henriksen Foundation, the Becket Foundation, and the Danish Diabetes Association. The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent Research Center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (www.metabol.ku.dk). JHS: We thank the Jackson Heart Study (JHS) participants and staff for their contributions to this work. The JHS is supported by contracts HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, HHSN268201300050C from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities. Dr. Wilson is supported by U54GM115428 from the National Institute of General Medical Sciences. KORA: The KORA study was initiated and financed by the Helmholtz Zentrum München – German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. Furthermore, KORA research was supported within the Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universität, as part of LMUinnovativ. Korcula: This work was funded by the Medical Research Council UK, The Croatian Ministry of Science, Education and Sports (grant 216–1080315-0302), the Croatian Science Foundation (grant 8875), the Centre of Excellence in Personalized health care, and the Centre of Competencies for Integrative Treatment, Prevention and Rehabilitation using TMS. LifeLines: The LifeLines Cohort Study and generation and management of GWAS genotype data for the LifeLines Cohort Study are supported by The Netherlands Organization of Scientific Research NWO (grant 175.010.2007.006), the Economic Structure Enhancing Fund (FES) of the Dutch government, the Ministry of Economic Affairs, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the Northern Netherlands Collaboration of Provinces (SNN), the Province of Groningen, University Medical Center Groningen, the University of Groningen, Dutch Kidney Foundation, and Dutch Diabetes Research Foundation. Niek Verweij is supported by NWO-VENI (016.186.125) and Marie Sklodowska-Curie GF (call: H2020-MSCA-IF-2014, Project ID: 661395). UHP: Folkert W. Asselbergs is supported by UCL Hospitals NIHR Biomedical Research Centre. Ilonca Vaartjes is supported by a Dutch Heart Foundation grant DHF project “Facts and Figures.” MGH-CAMP: Dr. Patrick Ellinor is funded by NIH grants (2R01HL092577, 1R01HL128914, R01HL104156, and K24HL105780) and American Heart Association Established Investigator Award 13EIA14220013 (Ellinor). Dr. Steve Lubitz is funded by NIH grants K23HL114724 and a Doris Duke Charitable Foundation Clinical Scientist Development Award 2014105. NEO: The authors of the NEO study thank all individuals who participated in the Netherlands Epidemiology in Obesity study, all participating general practitioners for inviting eligible participants, and all research nurses for collection of the data. We thank the NEO study group, Pat van Beelen, Petra Noordijk, and Ingeborg de Jonge for the coordination, lab, and data management of the NEO study. We also thank Arie Maan for the analyses of the electrocardiograms. The genotyping in the NEO study was supported by the Centre National de Génotypage (Paris, France), headed by Jean-Francois Deleuze. The NEO study is supported by the participating Departments, the Division and the Board of Directors of the Leiden University Medical Center, and by the Leiden University, Research Profile Area Vascular and Regenerative Medicine. Dennis Mook-Kanamori is supported by Dutch Science Organization (ZonMW-VENI Grant 916.14.023). RS-I: The generation and management of the Illumina Exome Chip v1.0 array data for the Rotterdam Study (RS-I) was executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. The Exome chip array dataset was funded by the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, from the Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO)-sponsored Netherlands Consortium for Healthy Aging (NCHA; project nr. 050–060-810); the Netherlands Organization for Scientific Research (NWO; project number 184021007); and by the Rainbow Project (RP10; Netherlands Exome Chip Project) of the Biobanking and Biomolecular Research Infrastructure Netherlands (BBMRI-NL; www.bbmri.nl). We thank Ms. Mila Jhamai, Ms. Sarah Higgins, and Mr. Marijn Verkerk for their help in creating the exome chip database, and Carolina Medina-Gomez, MSc, Lennard Karsten, MSc, and Linda Broer PhD for QC and variant calling. Variants were called using the best practice protocol developed by Grove et al. as part of the CHARGE consortium exome chip central calling effort. The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. The authors are grateful to the study participants, the staff from the Rotterdam Study, and the participating general practitioners and pharmacists. The work of Bruno H. Stricker is supported by grants from the Netherlands Organization for Health Research and Development (ZonMw) (Priority Medicines Elderly 113102005 to ME and DoelmatigheidsOnderzoek 80–82500–98-10208 to BHS). The work of Mark Eijgelsheim is supported by grants from the Netherlands Organization for Health Research and Development (ZonMw) (Priority Medicines Elderly 113102005 to ME and DoelmatigheidsOnderzoek 80–82500–98-10208 to BHS). SHIP: SHIP is supported by the BMBF (grants 01ZZ9603, 01ZZ0103, and 01ZZ0403) and the German Research Foundation (Deutsche Forschungsgemeinschaft [DFG]; grant GR 1912/5–1). SHIP and SHIP-TREND are part of the Community Medicine Research net (CMR) of the Ernst-Moritz-Arndt University Greifswald (EMAU) which is funded by the BMBF as well as the Ministry for Education, Science and Culture and the Ministry of Labor, Equal Opportunities, and Social Affairs of the Federal State of Mecklenburg-West Pomerania. The CMR encompasses several research projects that share data from SHIP. The EMAU is a member of the Center of Knowledge Interchange (CKI) program of the Siemens AG. SNP typing of SHIP and SHIP-TREND using the Illumina Infinium HumanExome BeadChip (version v1.0) was supported by the BMBF (grant 03Z1CN22). We thank all SHIP and SHIP-TREND participants and staff members as well as the genotyping staff involved in the generation of the SNP data. TWINSUK: TwinsUK is funded by the Wellcome Trust, Medical Research Council, European Union, the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. UKBB: This research has been conducted using the UK Biobank Resource (application 8256 - Understanding genetic influences in the response of the cardiac electrical system to exercise) and is supported by Medical Research Council grant MR/N025083/1. We also wish to acknowledge the support of the NIHR Cardiovascular Biomedical Research Unit at Barts and Queen Mary University of London, UK. PD Lambiase acknowledges support from the UCLH Biomedicine NIHR. MO is supported by an IEF 2013 Marie Curie fellowship. JR acknowledges support from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007–2013) under REA grant agreement no. 608765. YFS: The Young Finns Study has been financially supported by the Academy of Finland: grants 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; and Diabetes Research Foundation of Finnish Diabetes Association. The expert technical assistance in the statistical analyses by Irina Lisinen is gratefully acknowledged. Cell culture and biochemistry: Funding was provided by the National Institutes of Health (Program of Excellence in Glycoscience award HL107147 to SSA and F32AR063548 to TJM) and the David and Lindsay Morgenthaler Postdoctoral Fellowship (to TJM) and by the Allen Distinguished Investigator Program, through support made by The Paul G. Allen Frontiers Group and the American Heart Association (to SSA). Mutant mouse model: Adamts6 mutant mice were generated and further propagated and analyzed by funding provided by NIH grants HL098180 and HL132024 (to CWL) and by the Allen Distinguished Investigator Program, through support made by The Paul G. Allen Frontiers Group and the American Heart Association (to SSA).
Published: 2018

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19 results on '"Holm, Hilma"'

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4. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

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14. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

15. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

16. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

17. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

18. Mapping the human genetic architecture of COVID-19

19. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

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