1. An enhanced immune response in mice lacking the transcription factor NFAT1
- Author
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Xanthoudakis, Steven, Viola, Joao P.B., Shaw, Karen T.Y., Luo, Chun, Wallace, James D., Bozza, Patricia T., Curran, Tom, and Rao, Anjana
- Subjects
Immune response -- Genetic aspects -- Physiological aspects ,Genetic transcription -- Physiological aspects -- Genetic aspects ,Science and technology ,Physiological aspects ,Genetic aspects - Abstract
Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from [NFAT1.sup.-/-] mice showed increased primary responses to Leishmania major and mounted increased secondary responses to ovalbumin in vitro. in an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in [NFAT1.sup.-/-] mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response., The response of the immune system to antigen is coordinated by an interacting network of transcription factors that dictate expression of effector proteins such as cell surface receptors and cytokines [...]
- Published
- 1996