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Your search keyword '"Disease susceptibility -- Genetic aspects -- Risk factors"' showing total 35 results
Start Over Descriptor "Disease susceptibility -- Genetic aspects -- Risk factors" Topic genetic aspects
35 results on '"Disease susceptibility -- Genetic aspects -- Risk factors"'

1. Data on Colon Cancer Reported by Researchers at University of Baghdad (Novel Candidate Single Nucleotide Polymorphisms of ERCC2 Gene that Influence Colorectal Cancer Susceptibility)

Subjects
Genetic aspects, Risk factors, Genetic research -- Genetic aspects, Cancer genetics -- Risk factors -- Genetic aspects, Physical fitness, Cancer research -- Genetic aspects, Genes -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Single nucleotide polymorphisms -- Genetic aspects, Colorectal cancer -- Genetic aspects -- Risk factors, Oncology, Experimental -- Genetic aspects, Cancer -- Genetic aspects -- Research
Abstract

2024 OCT 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in colon cancer. According to news originating from [...]

Published
2024

2. Boston University School of Medicine Researcher Describes Findings in Ehlers-Danlos Syndrome (Decoding the Genetic Basis of Mast Cell Hypersensitivity and Infection Risk in Hypermobile Ehlers-Danlos Syndrome)

Subjects
Genetic aspects, Risk factors, Genetic research -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Biochemistry -- Genetic aspects, Medical research, Infection -- Risk factors -- Genetic aspects, Ehlers-Danlos syndrome -- Risk factors -- Genetic aspects, Medicine, Experimental
Abstract

2024 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Fresh data on Ehlers-Danlos syndrome are presented in a new report. According to news reporting [...]

Published
2024

3. Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke

Author

Szolnoki, Z., Somogyvari, F., Kondacs, A., Szabo, M., Fodor, L., Bene, J., and Melegh, B.

Subjects
Stroke (Disease) -- Risk factors -- Genetic aspects, Ischemia -- Risk factors -- Genetic aspects, Statistics, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Psychology and mental health, Genetic aspects, Risk factors
Abstract

J Neurol Neurosurg Psychiatry 2003;74:1615-1620 Objectives: Ischaemic stroke is a frequent heterogeneous multifactorial disease that is affected by a number of genetic mutations and environmental factors. We hypothesised the clinical [...]

Published
2003

4. An investigation of ACE as a risk factor for dementia and cognitive decline in the general population. (Letter to JMG)

Author

Yip, A.G., Brayne, C., Easton, D., and Rubinsztein, D.C.

Subjects
Dementia -- Risk factors -- Genetic aspects, Angiotensin converting enzyme -- Physiological aspects -- Genetic aspects, Alzheimer's disease -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Physiological aspects, Genetic aspects, Risk factors
Abstract

the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) * Dementia is the most common neurodegenerative condition affecting older people. It is estimated that around 550 000 subjects [...]

Published
2002

5. Genetic mapping of a susceptibility locus for disc herniation and spastic paraplegia on 6q23.3-q24.1

Author

Zortea, M., Vettori, A., Trevisan, C.P., Bellini, S., Vazza, G., Armani, M., Simonati, A., and Mostacciuolo, M.L.

Subjects
Intervertebral disk -- Hernia, Intervertebral disk displacement -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

It has been suggested that a genetic factor(s) or a familial predisposition may contribute to the clinical manifestations of disc herniation; moreover, no genetic linkage between spinal disc herniation and [...]

Published
2002

6. Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large finnish cohort. (Brief Genetics Report)

Author

Fingerlin, Tasha E., Erdos, Michael R., Watanabe, Richard M., Wiles, Kerry R., Stringham, Heather M., Mohlke, Karen L., Silander, Kaisa, Valle, Timo T., Buchanan, Thomas A., Tuomilehto, Jaakko, Bergman, Richard N., Boehnke, Michael, and Collins, Francis

Subjects
Calpain -- Physiological aspects -- Genetic aspects, Type 2 diabetes -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Physiological aspects, Genetic aspects, Risk factors
Abstract

Variations in the calpain-10 gene have recently been reported to be associated with type 2 diabetes in a Mexican-American population. We typed three single nucleotide polymorphisms (SNPs) in the calpain-10 [...]

Published
2002

7. The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302

Author

Nejentsev, Sergei, Reijonen, Helena, Adojaan, Bela, Kovalchuk, Liliya, Sochnevs, Arthur, Schwartz, Eugene I., Akerblom, Hans K., and Ilonen, Jorma

Subjects
Type 1 diabetes -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

The genes encoding the HLA-DQ heterodimer molecules, DQB1 and DQA1, have been found to have the strongest association with IDDM risk, although there is cumulative evidence for the effect of [...]

Published
1997

8. No independent associations of LMP2 and LMP7 polymorphisms with susceptibility to develop IDDM

Author

Undlien, Dag E., Akselen, Hanne E., Joner, Geir, Dahl-Jorgensen, Knut, Sovik, Oddmund, Ronningen, Kjersti S., and Thorsby, Erik

Subjects
Major histocompatibility complex -- Genetic aspects -- Risk factors, Type 1 diabetes -- Risk factors -- Genetic aspects, Genetic polymorphisms -- Health aspects -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors, Health aspects
Abstract

Results from a recent study suggested that polymorphisms within the HLA class II genes LMP2 and LMP7 were associated with the susceptibility for developing IDDM, and that this association could [...]

Published
1997

9. Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12

Author

Byrne, Maria M., Sturis, Jeppe, Menzel, Stephan, Yamagata, Kazuya, Fajans, Stefan S., Dronsfield, Mark J., Bain, Stephen C., Hattersley, Andrew T., Velho, Gilberto, Forguel, Phillipe, Bell, Graeme I., and Polonsky, Kenneth S.

Subjects
Diabetes -- Risk factors -- Genetic aspects, Pancreas -- Secretions, Glucose metabolism -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

One form of maturity-onset diabetes of the young (MODY) results from mutations in a gene, designated MODY3, located on chromosome 12 in band q24. The present study was undertaken to [...]

Published
1996

10. Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARγ gene and type 2 diabetes

Author

Memisoglu, Asli, Hu, Frank B., Hankinson, Susan E., Liu, Simin, Meigs, James B., Altshuler, David M., Hunter, David J., and Manson, Joann E.

Subjects
Disease susceptibility -- Genetic aspects -- Risk factors, Type 2 diabetes -- Risk factors -- Genetic aspects, Health, Genetic aspects, Risk factors
Abstract

OBJECTIVE--To determine whether the Pro12Ala polymorphism in the PPARγ gene was associated with risk of type 2 diabetes in the Nurses' Health Study. RESEARCH DESIGN AND METHODS--The study was a [...]

Published
2003

11. Acute Insulin Response to Intravenous Glucose Is Associated with a Polymorphism in the IGF2 Gene in Blacks

Author

SUN, GUANG, PERUSSE, LOUIS, GAGNON, JACQUES, WEISNAGEL, JOHN S., SKINNER, JAMES S., WILMORE, JACK H., LEON, ARTHUR S., PROVINCE, MIKE, RAO, D. C., and BOUCHARD, CLAUDE

Subjects
Genetic aspects, Risk factors, Health aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Type 2 diabetes -- Risk factors -- Genetic aspects, Black people -- Health aspects, Blacks -- Health aspects
Abstract

The association between an Apa I restriction fragment length polymorphism (RFLP) in the IGF2 gene locus (IGF2/Apa I) and plasma glucose, insulin and C-peptide levels in the fasting state and [...]

Published
2000

12. Molecular Basis and Characterization of the Hyperinsulinism/Hyperammonemia Syndrome

Author

Stanley, Charles A., Fang, Jie, Kutyna, Karen, Hsu, Betty Y.L., Ming, Jeffrey E., Glaser, Ben, and Poncz, Mortimer

Subjects
Diabetes in children -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

Predominance of Mutations in Exons 11 and 12 of the Glutamate Dehydrogenase Gene Glutamate dehydrogenase (GDH) is allosterically activated by the amino acid leucine to mediate protein stimulation of insulin [...]

Published
2000

13. Co-Expression of HLA DR3 and DQ8 Results in the Development of Spontaneous Insulitis and Loss of Tolerance to GAD65 in Transgenic Mice

Author

Abraham, Roshini S., Kudva, Yogish C., Wilson, S. Brian, Strominger, Jack L., and David, Chella S.

Subjects
Type 1 diabetes -- Risk factors -- Genetic aspects, Insulin resistance -- Causes of -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors, Causes of
Abstract

Specific HLA DQ and DR alleles have been associated with susceptibility to type 1 diabetes. HLA DQ8 and DQ2 have been shown to strongly predispose to disease and to be [...]

Published
2000

14. Reevaluation of the Major Histocompatibility Complex Genes of the NOD-Progenitor CTS/Shi Strain

Author

Mathews, Clayton E., Graser, Robert T., Serreze, David V., and Leiter, Edward H.

Subjects
Major histocompatibility complex -- Genetic aspects -- Risk factors, Type 1 diabetes -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

The common [K.sup.d] and/or [D.sup.b] alleles of NOD mice contribute to the development of autoimmune diabetes, but their respective contributions are unresolved. The major histocompatibility complex (MHC) of the CTS/Shi [...]

Published
2000

15. Genetic exercise capacity linked to heart disease

Author

Keller, Joy

Subjects
Heart diseases -- Risk factors -- Genetic aspects, Exercise, Medical research, Medicine, Experimental, Genetic research -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Sports and fitness, Genetic aspects, Risk factors
Abstract

Don't let your client get off that treadmill! A recent study sheds light on how in-born aerobic capacity may determine someone's cardiovascular disease risk. The study, published in the January [...]

Published
2005

16. UGT1A7 and colorectal cancer susceptibility. (Echo)

Subjects
Colorectal cancer -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

Direct evidence that sporadic colorectal cancers (CRCs) can arise from an interaction between genes and environment has come from a study of gene variation affecting the power of an enzyme [...]

Published
2002

17. Association of common genetic variant with susceptibility to invasive pneumococcal disease. (Research Pointers)

Author

Roy, S, Hill, AVS, Knox, K, Griffiths, D, and Crook, D

Subjects
Pneumococcal infections -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

Host factors influencing susceptibility to infection with Streptococcus pneumoniae remain incompletely understood, even though it is a major cause of infectious mortality. We report a genetic locus associated with susceptibility [...]

Published
2002

18. Limited role for HLA DR15 in MS. (Echo)

Subjects
Multiple sclerosis -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

HLA DR15 indicates susceptibility to multiple sclerosis (MS) but does not affect its course, Hensiek et al have confirmed. Previous studies have mostly been too small to confirm or refute [...]

Published
2002

19. Researchers find genetic basis for susceptibility to mycobacteria

Author

Josefson, Deborah

Subjects
Mycobacterial infections -- Risk factors -- Genetic aspects, Interferon gamma -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Cell receptors -- Genetic aspects, Health, Genetic aspects, Risk factors
Abstract

New research has suggested that there is a genetic reason why some people are more susceptible to infections with nontuberculous mycobacteria. Researchers at INSERM, in Paris, investigated disseminated non-tuberculous mycobacterial [...]

Published
1999

20. Anxiety disorders and major depression linked to decarboxylase genes

Subjects
Virginia Commonwealth University, Major depressive disorder -- Genetic aspects -- Risk factors, Genetic research, Glutamate, GABA, Anxiety -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Glutamate decarboxylase, Health, Science and technology, Genetic aspects, Risk factors
Abstract

According to recently published research from the United States, anxiety disorders, major depression, and neuroticism are associated with glutamic acid decarboxylase (GAD) genes. "Abnormalities in the gamma-aminobutyric acid (GABA) neurotransmitter [...]

Published
2006

21. Variations in detoxifying genes linked to Lou Gehrig disease

Subjects
Genetic research, Persian Gulf War veterans, Amyotrophic lateral sclerosis -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Science and technology, Genetic aspects, Risk factors
Abstract

Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis [...]

Published
2006

22. New susceptibility locus for hypertension identified on chromosome 8q

Subjects
Genetic research, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Science and technology, Genetic aspects, Risk factors
Abstract

A new susceptibility locus for hypertension has been identified on chromosome 8q by efficient pedigree-breaking in an Italian isolate. Researchers working in Italy report, "Essential hypertension (EH) affects a large [...]

Published
2006

23. Breast cancer risk perceptions reviewed

Subjects
Cognition, Breast cancer -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Science and technology, Genetic aspects, Risk factors
Abstract

Breast cancer risk perceptions were reviewed. According to recent research from New Zealand, "This study assessed the unique associations of risk perceptions and worry with attitudes about genetic testing for [...]

Published
2006

24. Single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes identified

Subjects
University of Tokyo, Medical research, Medicine, Experimental, Genetic research, Hepatitis C virus, Cancer -- Genetic aspects, Liver cancer -- Genetic aspects -- Risk factors, Hepatoma -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Science and technology, Genetic aspects, Risk factors
Abstract

A study from Japan has reported on a large-scale search of single nucleotide polymorphisms (SNPs) for hepatocellular carcinoma (HCC) susceptibility genes in patients with hepatitis C. "Hepatitis C virus (HCV) [...]

Published
2005

25. Single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes identified

Subjects
University of Tokyo, Genetic research, Hepatitis C virus, Cancer -- Genetic aspects, Liver cancer -- Genetic aspects -- Risk factors, Hepatoma -- Genetic aspects -- Risk factors, Hepatitis C -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

A study from Japan has reported on a large-scale search of single nucleotide polymorphisms (SNPs) for hepatocellular carcinoma (HCC) susceptibility genes in patients with hepatitis C. "Hepatitis C virus (HCV) [...]

Published
2005

26. XPD polymorphism increases breast cancer risk from PAH-DNA adducts/cigarettes

Subjects
Oncology, Experimental, Smoking -- Genetic aspects -- Risk factors, Cancer -- Genetic aspects -- Research, Breast cancer -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Cigarettes, Health, Science and technology, Genetic aspects, Risk factors
Abstract

An XPD gene polymorphism increases the risk of breast cancer from PAH-DNA adducts and cigarette smoking. "DNA repair is essential to an individual's ability to respond to damage caused by [...]

Published
2005

27. ERCC2 genotypes and corresponding haplotype linked with breast cancer risk

Subjects
Cancer -- Prevention -- Genetic aspects, Genotype, Breast cancer -- Genetic aspects -- Risk factors, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Science and technology, Diseases, Genetic aspects, Risk factors
Abstract

ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk. "The polygenic concept of breast cancer susceptibility calls for the identification of genetic variants that contribute to breast [...]

Published
2005

28. The loricrin gene is not involved in psoriasis susceptibility

Subjects
Genetic research, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Science and technology, Genetic aspects, Risk factors
Abstract

The loricrin gene is not involved in psoriasis susceptibility. According to published research from Italy, "psoriasis is a chronic inflammatory disease of the skin with both genetic and environmental risk [...]

Published
2005

29. Major histocompatibility complex class II genes control susceptibility to hypersensitivity pneumonitis in the mouse

Author

Donnelly, Kevin B., Brooks, Bradford O., Cruz, Enderson S., and Wassom, Donald L.

Subjects
Major histocompatibility complex -- Genetic aspects -- Risk factors, Hypersensitivity pneumonitis -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

Airborne exposure to organic and inorganic dusts, or to certain microbial antigens is known to cause hypersensitivity pneumonitis (HP) in animals and humans, but not all exposed individuals develop signs [...]

Published
1996

30. Genetic predisposition to ovarian cancer

Author

Freddo, James L.

Subjects
Cancer -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Ovarian cancer -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

Ovarian cancer remains the most common cause of death from gynecologic malignancy in developed countries. It was estimated that in 1991 20,700 new cases and about 13,000 deaths would occur [...]

Published
1992

31. Genetic Mutations Increase Susceptibility to Severe Disease

Subjects
Malaria -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

2000 JUL 4 - (NewsRx.com) -- CD36 gene mutations occur with very high frequency in African populations, researchers report in the June 29 issue of the journal Nature. They say [...]

Published
2000

32. Genetics a Factor in Susceptibility

Subjects
Disease susceptibility -- Genetic aspects -- Risk factors, Chronic active hepatitis -- Risk factors -- Genetic aspects, Health, Genetic aspects, Risk factors
Abstract

2000 JUN 13 - (NewsRx.com) -- A Mayo Clinic study has shown that genetic coding plays a significant role in susceptibility to acquiring autoimmune hepatitis, according to a report published [...]

Published
2000

33. Genetics: why some women smokers develop cancer and others don't

Subjects
Women -- Health aspects, Smokers -- Health aspects, Breast cancer -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors, Health aspects
Abstract

The answer to the question of whether smoking increases a woman's risk of developing breast cancer may lie in her genes, researchers at the University at Buffalo (UB) and the [...]

Published
1996

34. Role of cancer history defined in identifying BRCA1 gene test

Subjects
Breast cancer -- Risk factors -- Genetic aspects, Ovarian cancer -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors
Abstract

The risk of carrying a mutation in the BRCA1 gene is increased significantly in families in which there is one woman with early-onset breast cancer (before the age of 50) [...]

Published
1997

35. Family history and risk of colorectal cancer in the multiethnic population of Hawaii

Author

Lemarchand, L., Zhao, L.P., Quiaoit, F., Wilkens, L.R., and Kolonel, L.N.

Subjects
Familial diseases -- Risk factors -- Genetic aspects, Hawaiians -- Health aspects, Colorectal cancer -- Risk factors -- Genetic aspects, Disease susceptibility -- Genetic aspects -- Risk factors, Health, Genetic aspects, Risk factors, Health aspects
Abstract

Lemarchand, L.; Zhao, L.P.; Quiaoit, F.; Wilkens, L.R.; Kolonel, L.N. 'Family History and Risk of Colorectal Cancer in the Multiethnic Population of Hawaii.' American Journal of Epidemiology, December 15, 1996;144(12):1122-1128. [...]

Published
1997

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