11 results on '"Xiaofeng Qu"'
Search Results
2. Dynamic myocardial perfusion computed tomography with mental stress test to detect changes in myocardial microcirculation in patients with anxiety and no obstructive coronary artery disease
- Author
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Weihang Sun, Aodan Zhang, Lingjun Mei, Xiangting Liu, Zhongyan Li, and Xiaofeng Qu
- Subjects
Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2023
3. Rechargeable Aqueous Mn‐Metal Battery Enabled by Inorganic–Organic Interfaces
- Author
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Qi Yang, Xiaofeng Qu, Huilin Cui, Xincheng He, Yuan Shao, Yong Zhang, Xun Guo, Ao Chen, Ze Chen, Rong Zhang, Duanyang Kong, Zhicong Shi, Jun Liu, Jieshan Qiu, and Chunyi Zhi
- Subjects
General Chemistry ,General Medicine ,Catalysis - Abstract
Aqueous batteries that use metal anodes exhibit maximum anodic capacity, whereas the energy density is still unsatisfactory partially due to the high redox potential of the metal anode. Current metal anodes are plagued by the dilemma that the redox potential of Zn is not low enough, whereas Al, Mg, and others with excessively low redox potential cannot work properly in aqueous electrolytes. Mn metal with a suitably low redox potential is a promising candidate, which was rarely explored before. Here, we report a rechargeable aqueous Mn-metal battery enabled by a well-designed electrolyte and robust inorganic-organic interfaces. The inorganic Sn-based interface with a bottom-up microstructure was constructed to preliminarily suppress water decomposition. With this bubble-free interface, the organic interface can be formed via an esterification reaction of sucrose triggered by acyl chloride in the electrolyte, generating a dense physical shield that isolates water while permitting Mn
- Published
- 2022
4. Peri-procedural variables and outcomes of long-period hemodynamic instability after carotid artery angioplasty and stenting
- Author
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Bo Li, Weijian Fan, Yihan Yang, Xiaofeng Qu, Jindong Tong, Yizhi Liu, Jinyun Tan, Weijian Jiang, and Bo Yu
- Subjects
Radiology, Nuclear Medicine and imaging ,Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Objectives The aim of this study is to identify the peri-procedural risk factors and outcomes of hemodynamic instability (HI) after carotid artery stenting (CAS). Methods A single-center, retrospective study was performed in 168 patients who underwent CAS procedure between September 2017 and September 2020. The presence of HI, as defined by hypertension (systolic blood pressure >160 mmHg), hypotension (systolic blood pressure Results Among 168 patients (mean age, 68.2 ± 8.3 years; 81.5% male), the frequency of post-procedural long-period HI was noted in 42 patients (25.0%). Male was prone to experience HI (odds ratio, 9.156, p = 0.021). Aggressive inflation pressure (>7 atm) and 5 mm balloon for pre-dilatation were risk factors of long-period HI (OR, 7.372, p = 0.035; OR, 3.527, p = 0.023). Intraoperative peak blood pressure and larger-sized stents remained independent predictors for the development of HI (OR, 1.043, p = 0.027, and OR, 1.973, p = 0.015). Patients with prolonged HI were more likely to suffer TIA and stroke compared to other patients and significant difference was found in the occurrence of TIA ( p < 0.05). Non-significance was found in mortality rate and other outcomes. Conclusions CAS-induced HI occurs in a considerable percentage while several peri-procedural variables are determined as independent predictors to develop long-period HI. Patients with prolonged HI are associated with increased risk of neurologic events and thus standardized intervention as well as management of long-period HI are of critical importance during clinical process.
- Published
- 2022
5. Asymmetric pathological pachymeningeal enhancement: A new imaging feature for cerebral venous thrombosis
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Ying Liu, Qingwen Sun, Qi Yang, Zhaoyang Fan, Debiao Li, Xiaofeng Qu, and Ce Zhang
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Adult ,Male ,medicine.medical_specialty ,Clinical onset ,03 medical and health sciences ,Sinus Thrombosis, Intracranial ,0302 clinical medicine ,Meninges ,medicine ,Humans ,Thrombus ,Pathological ,Retrospective Studies ,Imaging Feature ,Venous Thrombosis ,medicine.diagnostic_test ,business.industry ,Angiography, Digital Subtraction ,Magnetic resonance imaging ,Retrospective cohort study ,General Medicine ,Phlebography ,Middle Aged ,medicine.disease ,Cerebral Veins ,Magnetic Resonance Imaging ,Venous thrombosis ,Early Diagnosis ,030220 oncology & carcinogenesis ,Case-Control Studies ,Surgery ,Female ,Neurology (clinical) ,Intracranial Atherosclerosis ,Radiology ,Dura Mater ,Intracranial Thrombosis ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Purpose Cerebral venous thrombosis (CVT) has various clinical presentations and has a median onset delay of 7 days. So it is important to find more identifiable early imaging manifestations for CVT. Method This was a retrospective study. Patients with CVT (CVT group, n = 26) diagnosed by conventional imaging techniques (magnetic resonance imaging and/or digital subtraction angiogram) and patients with symptomatic intracranial atherosclerosis (control group, n = 30) were included. Magnetic resonance black-blood thrombus imaging (MRBTI) technique had been performed in both groups. The CVT group was divided into 3 groups based on the duration of clinical onset: ≤7 days (group 1), between 7 and 30 days (group 2), and >30 days (group 3). Pathological pachymeningeal enhancement and its characteristics were analyzed between the CVT group and the control group. Results Pathological pachymeningeal enhancement was found in 14 CVT patients (54 %) and none in control group (P value = 0.000). The bilateral pathological pachymeningeal enhancement was involved in 10 CVT patients, 6 patients were asymmetric, and 4 patients had ipsilateral enhancement. Asymmetric pathological pachymeningeal enhancement was 71 % and predominantly located on the thrombosed sinus side. Strong enhancement was found in the venous sinus wall beside the thrombus. Pathological pachymeningeal enhancement percentages of three subgroups were 75 % in group 1, 55 % in group 2, and 29 % in group 3 and had no statistical differences (p value = 0.198). Conclusions Current findings suggest asymmetrical pathological pachymeningeal enhancement was associated was CVT and may be a new imaging feature for CVT.
- Published
- 2020
6. Layer-by-layer assembly of polyoxometalate-pyrene-decorated fluorescent microspheres for the suspension immunoassay of Listeria monocytogenes
- Author
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Dehui Yin, Kun Xu, Li Li, Gang Yan, Li Juan, Wen Ju, Yangguang Li, Xiuling Song, Wang Juan, and Xiaofeng Qu
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Detection limit ,Materials science ,Chromatography ,medicine.diagnostic_test ,Biomedical Engineering ,Analytical chemistry ,02 engineering and technology ,General Chemistry ,General Medicine ,Conjugated system ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Photobleaching ,Fluorescence ,0104 chemical sciences ,Matrix (chemical analysis) ,chemistry.chemical_compound ,chemistry ,Immunoassay ,medicine ,Pyrene ,General Materials Science ,0210 nano-technology ,Luminescence - Abstract
A fluorescence microsphere suspension array technique has been developed as a promising tool for the molecular detection of Listeria monocytogene (LM), which is a dangerous food borne pathogen that can cause severe food intoxication in both humans and animals. In such a technique, fluorescent microspheres as the key matrix for detection are often decorated with neutral organic dyes, which usually suffer from instability, easy photobleaching and loss from the matrix. Herein, we design and synthesize a new organic–inorganic hybrid POM–pyrene compound [N(C4H9)4]2[V6O13{(OCH2)3CNH–CH2–C16H9}2] (1), which is employed as a negatively-charged fluorescent material to prepare a new class of fluorescent microspheres by a layer-by-layer electrostatic self-assembly method. As a result, such POM–pyrene-decorated fluorescent microspheres possess obvious luminescence properties, superior photo-stability and long-term stability. Therefore, the POM–pyrene-decorated fluorescent microspheres are conjugated by monoclonal anti-LM antibodies, and introduced into the fluorescence microsphere-based suspension immunoassay system for the detection of LM in food, which exhibits a high sensitivity. The lowest limit of detection (LOD) of LM in artificially contaminated meat is down to 6 CFU g−1 without cross-reactivity with other pathogens. Furthermore, the suspension immunoassay based on PS@POM–pyrene microspheres shows excellent specificity to LM, good repeatability and high efficiency in contrast to the conventional culture-based method.
- Published
- 2020
7. Recanalization of symptomatic chronic internal carotid artery occlusions by hybrid treatment
- Author
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Jianjie Rong, Bo Li, Bingxin Jiang, Yizhi Liu, Xiaofeng Qu, and Weijian Fan
- Subjects
Adult ,Male ,medicine.medical_specialty ,Subarachnoid hemorrhage ,medicine.medical_treatment ,Carotid endarterectomy ,Revascularization ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,medicine ,Humans ,Carotid Stenosis ,Stroke ,Aged ,Retrospective Studies ,Endarterectomy, Carotid ,business.industry ,Endovascular Procedures ,Montreal Cognitive Assessment ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Reperfusion ,Female ,Stents ,Neurology (clinical) ,Internal carotid artery ,business ,030217 neurology & neurosurgery ,Postoperative Hypertension - Abstract
To evaluate the efficacy and safety of hybrid revascularization by carotid endarterectomy and endovascular intervention in the treatment of chronic internal carotid artery occlusion (ICAO).We performed a retrospective analysis of patients who received hybrid treatment for symptomatic chronic ICAO between December 2016 and December 2018. Fifty-six patients with long-segment ICAO were enrolled and divided into the short duration (1-3 months) and long ICAO duration (3 months) groups, and their clinical and angiographic data were analyzed.The mean duration was 106.8 ± 36.1 days from the date of ICAO diagnosis to revascularization. Totally, 10 patients (17.8%, n = 56) in the short duration group while no patients in the long duration group failed recanalization (n = 7). Perioperative complications included intraoperative thromboembolism in 1 (1.8%) patient and subarachnoid hemorrhage in 2 (3.6%) patients. Early phase postoperative hypertension was noted in 11 (19.6%) patients and cervical hemorrhage in 1 (1.8%) patient. No severe neurological deficits occurred. Overall, the 6-month modified Rankin score, Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in patients with successful recanalization significantly improved versus the baseline (P 0.05). After successful recanalization, the long duration group demonstrated more stents for revascularization compared with the short duration group (P 0.05). Five (10.8%) patients had recurrent transient ischemic attack, and 1 (2.2%) patient developed stroke in the successful revascularization group during 6 months of follow-up. ICA restenosis occurred in 5 (8.9%) patients and re-occlusion was noted in 1 (1.8%) patient.Hybrid operation may be feasible and effective for patients with symptomatic chronic complete ICAO according to our limited data. The original occlusion site from the carotid bifurcation and the duration of ICAO should be considered as independent indicators for successful recanalization as well as perioperative outcomes.
- Published
- 2021
8. Evaluation of the 3D Augmented Reality-Guided Intraoperative Positioning of Dental Implants in Edentulous Mandibular Models
- Author
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Longfei Ma, Yingwei Fan, Hongen Liao, Xiaofeng Qu, Boyu Zhang, Xinran Zhang, and Weipeng Jiang
- Subjects
Computer science ,medicine.medical_treatment ,Point cloud ,Overlay ,Mandible ,Stereotaxic Techniques ,03 medical and health sciences ,User-Computer Interface ,0302 clinical medicine ,Imaging, Three-Dimensional ,medicine ,Humans ,Maxillary central incisor ,Computer vision ,030212 general & internal medicine ,Dental implant ,Dental Implants ,business.industry ,Phantoms, Imaging ,030206 dentistry ,General Medicine ,Surgery, Computer-Assisted ,Virtual image ,Printing, Three-Dimensional ,Augmented reality ,Artificial intelligence ,Implant ,Tomography ,Oral Surgery ,Mouth, Edentulous ,business ,Tomography, X-Ray Computed - Abstract
PURPOSE This research aimed to propose a three-dimensional (3D) augmented reality navigation method with point cloud-based image-patient registration that could merge virtual images in the real environment for dental implants using a 3D image overlay and to evaluate its feasibility. MATERIALS AND METHODS A total of 12 rapid prototyping mandibular models were fabricated using a 3D printing method and were divided into two groups: 3D augmented reality-guided group and traditional two-dimensional (2D) image-guided group. A point cloud-based preoperative image-to-patient registration method was introduced to replace the traditional point-to-point registration. After the registration, dental implant surgery was performed in the two model groups using an augmented reality-guided navigation method and a traditional two-dimensional image-guided navigation method. The planned and actual postoperative implant positions were compared for measuring positional implantation errors. The surgery time was also recorded and compared between the two groups. RESULTS In the model experiment, the root-mean-square deviation of registration was 0.54 mm, and the implant surgery results showed < 1.5-mm mean linear deviation and < 5.5-degree angular deviation. The augmented reality-guided implantation showed smaller horizontal, vertical, and angular errors in the apical areas of the central incisor and the canine region. The surgery time using the augmented reality-guided navigation method was significantly shorter than that using the two-dimensional (2D) image-guided navigation method (P < .05). Moreover, the volunteer experiment demonstrated that the preoperative 3D models in situ accurately overlaid onto the surgical site. CONCLUSION The proposed point cloud-based registration method can achieve excellent registration accuracy. Dental implant placement guided by the proposed 3D augmented reality navigation method showed better accuracy and applicability, as well as higher efficiency, than the traditional 2D image navigation method.
- Published
- 2018
9. Development of atherosclerotic-moyamoya syndrome with genetic variant of RNF213 p.R4810K and p.T1727M: A case report
- Author
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Xueying Wu, Yongzhong Lin, Zhaoyang Fan, Lele Zhong, Jingdan Cheng, Xiaofeng Qu, and Ying Liu
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medicine.medical_specialty ,Exacerbation ,media_common.quotation_subject ,Ubiquitin-Protein Ligases ,Magnetic resonance angiography ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,medicine ,Anterior cerebral artery ,Humans ,Genetic Predisposition to Disease ,030212 general & internal medicine ,media_common ,Adenosine Triphosphatases ,Daughter ,Adult female ,medicine.diagnostic_test ,business.industry ,Haplotype ,Genetic variants ,General Medicine ,Middle Aged ,medicine.disease ,Stenosis ,Cerebrovascular Disorders ,Mutation ,Cardiology ,Surgery ,Female ,Neurology (clinical) ,Moyamoya Disease ,business ,030217 neurology & neurosurgery ,Magnetic Resonance Angiography - Abstract
Objective We report a rare case of atherosclerotic-moyamoya syndrome (A-MMS) in an adult female with genetic variant of both ring finger 213 (RNF213) p.R4810K and p.T1727M. Case report A 46-year-old previously healthy, right-handed woman displayed transient slurred speech, which started to worsen four years ago. Initial magnetic resonance angiography (MRA) revealed stenosis in left middle cerebral artery (MCA), bilateral anterior cerebral artery (ACA), and left posterior cerebral artery (PCA). The patient subsequently underwent catheter angiography, which confirmed the formation of moyamoya vessels, with Suzuki's angiographic staging of grade-3 on the left side. Although the patient had been on both anti-platelet and statin therapy at the time, a follow-up examination showed further exacerbation of left MCA stenosis, along with enhanced moyamoya vessel formation. On black-blood imaging using DANTE-SPACE, there were eccentric, evolving lesions in the left MCA. We next screened for potential genetic variants, using genomic DNA samples isolated from both the patient and her immediate family members. The results showed that the patient, along with her mother, sister, and brother, possessed the heterozygous variant of the RNF213 gene, including c.14429G > A (p.R4810K) and c.5180C > T (p.T1727M). The patient's daughter did not have the variant. Conclusion Collectively, we present a unique case of A-MMS with genetic variant of RNF213 p.R4810K and p.T1727M, manifesting as progression. Based on the family tree, these two mutations are on the same RNF213 haplotype. Whether atherosclerosis is the cause of A-MMS or it further exacerbates the injury of MMD to the A-MMS patients with RNF213 gene variant is a question to be investigated.
- Published
- 2017
10. Effect of phosphodiesterase type 5 inhibitors on prostate cancer risk and biochemical recurrence after prostate cancer treatment: A systematic review and meta-analysis
- Author
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Qingqing Qian, Ju Xia, Yang Wang, Yang Hong, Xiaofeng Qu, Yougen Wu, and Yuting Gu
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Male ,Oncology ,Biochemical recurrence ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Endocrinology ,Erectile Dysfunction ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prostatectomy ,030219 obstetrics & reproductive medicine ,business.industry ,Prostatic Neoplasms ,General Medicine ,Odds ratio ,Phosphodiesterase 5 Inhibitors ,Prostate-Specific Antigen ,medicine.disease ,Radiation therapy ,Erectile dysfunction ,Relative risk ,Meta-analysis ,Neoplasm Recurrence, Local ,business - Abstract
Recent studies have examined the impact of phosphodiesterase type 5 inhibitors (PDE5-Is) use on the risk of prostate cancer, and biochemical recurrence (BCR) in prostate cancer patients, but the results were inconsistent. A meta-analysis was conducted to assess the associations with all published studies. Databases (PubMed, Web of Science and MEDLINE) were retrieved to identify relevant studies which explored the impact of PDE5-Is use on the risk of prostate cancer, and BCR in prostate cancer patients. The summary results along with 95% confidence intervals (CIs) were calculated. Nine articles were eligible for the inclusion criteria. The pooled analysis showed that PDE5-Is use was not related to the increased risk of prostate cancer (odds ratio (OR), 0.71; 95% CI, 0.40-1.29). Moreover, PDE5-Is use was not linked to BCR risk in prostate cancer patients with erectile dysfunction (ED) following radical prostatectomy or radiation therapy (relative risk (RR), 1.09; 95% CI, 0.89-1.34). The heterogeneity test suggested moderate heterogeneity across studies. PDE5-Is use does not influence the risk of prostate cancer, and BCR in prostate cancer patients. More well-designed studies are warranted to confirm the findings of our analyses.
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- 2018
11. Pharmacokinetics of Anti-HBV Polyoxometalate in Rats
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Xiuling Song, Dehui Yin, Jinhua Li, Li Li, Juan Wang, Juan Li, Xiaofeng Qu, Yanfei Qi, and Kun Xu
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Male ,Drug Research and Development ,Metabolic Clearance Rate ,Immunology ,lcsh:Medicine ,Urine ,Pharmacology ,Antiviral Agents ,General Biochemistry, Genetics and Molecular Biology ,Excretion ,Antiviral Therapy ,Pharmacokinetics ,Oral administration ,Medicine and Health Sciences ,medicine ,Animals ,Tissue Distribution ,Rats, Wistar ,lcsh:Science ,Feces ,Kidney ,Multidisciplinary ,Chemistry ,lcsh:R ,Biology and Life Sciences ,Metabolism ,General Medicine ,Tungsten Compounds ,Vaccination and Immunization ,Blood proteins ,Rats ,medicine.anatomical_structure ,lcsh:Q ,General Agricultural and Biological Sciences ,Research Article - Abstract
Polyoxometalates are non-nucleoside analogs that have been proven to exhibit broad-spectrum antiviral activity. In particular, Cs2K4Na[SiW9Nb3O40].H2O 1 shows low toxicity and high activity against HBV. The preclinical pharmacokinetics of Compound 1 in rats were characterized by establishing and applying inductively coupled plasma-mass spectrometry method to determine the concentration of W in plasma, urine, feces, bile and organ samples. The quantitative ICP-MS method demonstrated good sensitivity and application in the pharmacokinetics study of polyoxometalates. The pharmacokinetic behavior of Compound 1 after intravenous or oral administration fit a two-compartment model. Tmax ranges from 0.1 h to 3 h and the T1/2 of Compound 1 is between 20 h and 30 h. The absolute bioavailability of Compound 1 at 45, 180 and 720 mg/kg groups were 23.68%, 14.67% and 11.93%, respectively. The rates of plasma protein binding of Compound 1 at 9, 18 and 36 mg/ml of Compound 1 are 62.13±9.41%, 71.20±24.98% and 49.00±25.59%, respectively. Compound 1 was widely distributed throughout the body, and high levels of compound 1 were found in the kidney and liver. The level of Compound 1 in excretion was lower: 30% for urine, 0.28% for feces and 0.42% for bile, respectively. For elaborate pharmacokinetic characteristics to be fully understood, the metabolism of Compound 1 needs to be studied further.
- Published
- 2014
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