1. Prediction of posthepatectomy liver failure using transient elastography in patients with hepatitis B related hepatocellular carcinoma
- Author
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Yan Chen, Wan-bin Li, Jia Guo, Xiao-yu Ji, Jie-wen Lei, Jun-feng Hong, and Yan Pan
- Subjects
Male ,medicine.medical_specialty ,HBsAg ,Cirrhosis ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,medicine.medical_treatment ,Posthepatectomy liver failure ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Hepatitis B, Chronic ,Postoperative Complications ,Internal medicine ,medicine ,Hepatectomy ,Humans ,Liver stiffness measurement ,lcsh:RC799-869 ,business.industry ,Liver Neoplasms ,General Medicine ,Odds ratio ,Hepatology ,Hepatitis B ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Preoperative Period ,Elasticity Imaging Techniques ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Female ,business ,Transient elastography ,Liver Failure ,Research Article - Abstract
Background It is essential to accurately predict Postoperative liver failure (PHLF) which is a life-threatening complication. Liver hardness measurement (LSM) is widely used in non-invasive assessment of liver fibrosis. The aims of this study were to explore the application of preoperative liver stiffness measurements (LSM) by transient elastography in predicting postoperative liver failure (PHLF) in patients with hepatitis B related hepatocellular carcinoma. Methods The study included 247 consecutive patients with hepatitis B related hepatocellular carcinoma who underwent hepatectomy between May 2015 and September 2015. Detailed preoperative examinations including LSM were performed before hepatectomy. The endpoint was the development of PHLF. Results All of the patients had chronic hepatitis B defined as the presence of hepatitis B surface antigen (HBsAg) for more than 6 months and 76 (30.8%) had cirrhosis. PHLF occurred in 37 (14.98%) patients. Preoperative LSM (odds ratio, OR, 1.21; 95% confidence interval, 95% CI: 1.13–1.29; P
- Published
- 2017