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1. Suitability of laser stimulated TLD arrays as patient dose monitors in high dose x-ray imaging

Author

Beth A. Schueler, S. C. Jones, Richard A. Geise, and W. Lien

Subjects
Materials science, Radiography, Biophysics, Magnesium Compounds, Biophysical Phenomena, Borates, medicine, Humans, Dosimetry, Fluoroscopy, Radiation Injuries, Technology, Radiologic, Skin, Reproducibility, Dosimeter, medicine.diagnostic_test, business.industry, Lasers, X-ray, Reproducibility of Results, General Medicine, Ionization chamber, Thermoluminescent Dosimetry, Thermoluminescent dosimeter, Nuclear medicine, business
Abstract

Skin entrance doses of patients undergoing interventional x-ray procedures are capable of causing skin damage and should be monitored routinely. Single TLD chips are not suitable because the location of maximum skin exposure cannot be predicted. Most photographic films are too sensitive at diagnostic x-ray energies for dosimetry, exhibit temporal changes in response, and require special packaging by the user. We have investigated the suitability of laser heated MgB 4 O 7 TLDs in a polyimide binder in the range of 0.2–20 Gy. These are available in radioluscent arrays up to 30×30 cm for direct measurement of patient skin dose. Dose response was compared with a calibrated ion chamber dosimeter. Exposures were made at 60, 90, and 120 kVp, at low (fluoroscopy) and high (DSA) dose rates, and at different beam incidence angles. Longitudinal reproducibility and response to temperature changes during exposure were also checked. The dose response is linear below approximately 6 Gy where the slope starts to increase 2% per Gy. Errors were less than ±2% over a 0–80 degree range of beam incidence angles; less than ±3% for both dose rate variations and kVp differences between 70 and 120 kVp. The response was unaffected by temperature changes between 20 and 37 °C. Reproducibility is currently ±7%. MgB 4 O 7 TLD arrays are suitable for patient dosimetry in high dose fluoroscopy procedures if appropriate calibrations are used. Uncertainty in skin dose measurement is less than 10%, which is substantially better than film dosimetry.

Published
1997
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2. American Society of Colon and Rectal Surgeons 95th Annual Convention Podium and Poster Abstracts June 9-14, 1996 Seattle, Washington

Author

J. M. Church, R. R. Dozois, T. Heimann, L. L. Jensen, D. Quinn, J. S. Morrow, K. Sniderman, L. E. Smith, G. Steele, P. Barton, M. Kojima, F. Breen, J. M. Hain, Z. Cohen, S. R. Gorfine, R. Bleday, S. M. Sentovich, J. F. Stebbing, R. Kerr, J. M. Harmon, A. M. Rai, P. W. R. Lee, P. Hayes, W. C. Lin, E. C. Lee, R. Nowygrod, C. Burul, G. Grado, Y. N. Kang, A. S. Miller, K. C. Hsu, Y. Tsuji, G. R. Greenberg, M. Bessler, T. Tsukamoto, M. F. Chen, A. M. Vernava, J. Konsten, M. Ippoliti, J. R. T. Monson, P. M. Sagar, D. Laird, C. S. Richard, E. Max, D. Zhou, B. Trock, H. M. MacRae, D. Glass, W. L. Law, R. Bellantone, B. Bapat, B. O'Connor, F. C. Chen, P. Busse, H. Rockette, P. L. Benn, R. Buras, M. Bernstein, B. Stabile, J. Devine, D. C. N. K. Nyam, M. Wronski, K. W. Smith, E. McGannon, C. Tsang, J. M. Buzelin, N. Petrelli, M. Franklin, J. W. Milsom, M. Morris, G. J. Blatchford, S. Evans, E. Ton, H. D. Park, K. Kanazawa, M. B. Hadfield, F. Seow-Choen, A. Dünne, J. Choi, S. Senba, J. M. Sarmiento, A. Cureshi, J. C. Kim, O. Streeter, D. Schoetz, E. Arbit, M. Spellman, J. B. Gathright, J. Wu, V. Valentini, C. Laramee, K. S. Song, T. G. S. Sardinha, P. J. Hewett, K. S. Khanduja, M. Thorne, J. A. Reis Neto, C. Thibault, R. Guttman, A. Gardiner, W. R. Wrightson, J. M. Jessup, T. Berk, P. C. Rantis, C. Mosdal, L. Rusin, R. McLeod, U. Stadelmaier, C. A. Ternent, M. Blackstein, K. A. Ludwig, J. Y. Wang, J. Milsom, K. Krogh, L. Stamm, M. T. Harris, S. Laurberg, S. Zaheer, N. H. Hyman, Ch. Chaimoff, M. Shabahang, C. Elbetti, D. Van, N. J. Espat, D. E. Beck, A. G. Thorson, T. Okamoto, K. W. Schmid, J. D. F. Allendorf, M. Tada, D. J. SchoetzJr., W. S. Chen, P. L. Roberts, I. M. Gelemt, R. Fry, E. Birnbaum, J. Stasik, P. Conti, L. R. Sands, J. M. Enriquez, T. K. Weber, P. B. McIntyre, J. J. Nogueras, D. Obrand, S. Rowley, T. Togashi, S. Malhorta, Duane M. Ilstrup, L. Madlensky, P. V. Vignati, L. Schumaker, D. G. Kim, M. E. Sher, G. Ault, M. Endo, M. R. B. Keighley, K. Kozell, S. Korsgen, M. Krecker, J. Gilliland, D. Shibata, M. C. Veidenheimer, R. Steinhagen, M. T. Dayton, E. G. Weiss, A. W. MacDonald, G. Navaro, T. R. Newton, R. Nauta, J. M. Fernandez Madrid, M. Uskokovic, Heidi Nelson, J. P. Welch, F. Agachan, G. B. Doglietto, K. Horvath, D. M. Ilstrup, T. Ross, W. A. Koltun, P. A. Lehur, M. R. Moran, O. Ceron, A. Alexander, R. M. Durham, S. A. Strong, J. Pfeifer, S. Oliart, A. DelPino, H. Morimoto, P. Belliveau, I. Khubchandani, B. L. Stein, H. Inoue, K. Siminovich, A. M. VernavaIII, Y. Jang, P. S. Aguilar, M. A. Rodríguez-Bigas, J. Feeney, J. J. Perez-Ramirez, J. Nielsen, D. M. Hyams, R. Brenner, L. Gunderson, G. J. Sellers, M. Eaton, J. Wexler, J. M. Dominguez, J. J. Murray, F. Michot, S. L. Behen, J. Olenwine, J. Rakinic, A. H. Steinhart, B. T. Gemlo, A. Buffan, C. A. Vasilevsky, J. M. Becker, F. G. Opelka, C. Ratto, Bruce G. Wolff, O. Ogunbivi, D. R. Butts, L. C. Rusin, P. R. Williamson, I. Kodner, M. Tan, G. L. Daniel, D. W. Wong, A. J. Combs, T. M. Young-Fadok, C. B. Whitlow, W. E. WiseJr., S. Groshen, A. Vladisavljevic, N. Wolmark, A. Gonzalez, F. Crucitti, J. Marshall, R. Nelson, J. R. Cali, R. Beart, M. Treat, E. Lee, R. Tang, Nicholas J. Talley, S. D. Wexner, M. Shashidharan, J. C. Djurhuus, K. Atkinson, S. Gallinger, W. T. Reilly, S. Casillas, M. R. Treat, Y. Takao, B. F. Warren, E. Garcia-Granero, A. Ferrara, R. Koren, W. P. Pennoyer, A. J. Simons, F. A. Frizelle, W. H. Yoon, J. H. Galicich, W. G. Lewis, John H. Scholefield, Jonathan N. Lund, C. Greenwood, H. Onodera, M. A. Memon, J. Murray, W. E. Longo, A. Wright, P. W. Marcello, Y. H. Ho, S. Sentovich, S. W. Larach, Y. S. Ho, D. L. Tusek, W. D. Wong, J. M. Devesa, C. Orsay, O. C. Velázquez, Lars Påhlman, E. T. Goldstein, M. T. Yasin, S. Lledo, R. Riether, B. Brandt, S. C. Jones, J. V. Garcia, M. Bilsky, J. S. Joo, P. Sagar, B. Taylor, F. Konishi, Alan R. Zinsmeister, E. Heineman, A. Ortega, C. Sala, D. W. McFadden, R. W. Golub, H. Kashiwagi, R. B. Rustin, S. A. Roh, F. Cordeiro, S. Sabroe, D. Anderson, R. W. Seto, R. Pearl, J. Allendorf, H. R. Bailey, R. Ross, S. Wilson, A. Tan, G. Anthone, L. Rosen, C. I. Reis Neto, D. W. Dietz, U. D. F. Allendorf, R. Goes, M. Redston, O. Ilahi, P. Marchesa, J. Nolla, G. Wilmoth, W. M. Thomas, D. Singer, R. B. Hanson, P. J. Maccabee, R. S. McLeod, T. E. Read, N. Talley, S. R. Myers, R. Silverman, S. J. Stryker, L. Messerini, R. D. Madoff, W. Hyland, M. Kroll, W. Hohenberger, S. Kyzer, D. DeMarta, C. D. Liu, M. A. S. Chapman, I. Kreel, E. Breen, D. A. Rothenberger, M. Bockler, F. Marchetti, J. R. Levy, H. Hsu, B. P. Geerdes, N. J. McC. Mortensen, M. J. Stamos, W. Geerts, J. Ong, J. Leborgne, S. Bouchard, J. Grass, J. Gunn, L. Weston, J. L. Cohen, S. M. Goldberg, C. J. Bruce, R. L. Whelan, D. Hudzinski, J. A. Coller, P. Vukasin, G. Ozuner, A. C. Lowry, M. I. Brand, M. A. Christensen, S. H. Koo, Lawrence J. Burgart, S. W. Ashley, E. A. Grose, J. Cohen, N. Daniel, A. Jabbar, G. S. Duthie, H. Osswald, M. Burnstein, A. Horsman, C. Fucini, M. Imamura, R. Gregoire, D. Johnston, A. Simons, M. E. R. Williamson, L. P. Prabhakar, L. Sofo, G. N. Rao, M. W. Thompson-Fawcett, N. J. Petrelli, K. E. Matzel, E. Mamounas, T. Hull, N. J. M. Mortensen, G. Sellers, C. Cruz, J. H. Pemberton, M. P. Spencer, F. A. Quilici, R. O. Parra, L. Gottesman, J. Goldblum, D. Nagle, S. Maetani, R. Salem, R. Whelan, R. LaRocca, J. Jones, M. Trokel, S. Ferzoco, P. H. Grise, J. E. Hartley, L. W. Allen, C. Toms, E. Montgomery, N. Abdullah, G. St. Marie, B. A. Kerner, S. Galandiuk, A. A. Nicholson, Robert Steele, H. S. Stern, R. Farouk, L. Oliveira, P. J. Drew, P. Nucera, J. A. ReisJr., V. Fazio, M. Rosenblatt, S. Sobzcak, G. Winde, Y. T. You, C. G. M. Baeten, R. Gal, P. J. Holdsworth, J. J. Bauer, E. R. Stephenson, E. M. Bass, M. J. Molina, S. Rai, L. W. Turnbull, P. Denis, R. C. Rantis, M. Takano, J. S. Chen, D. W. King, J. Fleshman, R. Müller, J. E. Blair, M. C. Mahoney, M. Stuntz, J. Coller, A. H. Smith, P. Decanini-Garza, J. Kuromizu, J. H. Sun, J. L. Rombeau, C. S. Lee, J. Trudel, D. M. Meesig, F. Lee, J. Edwards, G. King, P. Roberts, V. W. Fazio, M. Tsubaki, B. D. Wolff, A. F. Brading, P. S. Rooney, G. Pruitt, P. Lucha, C. D. Schleck, H. Kahn, A. Garcia-Ruiz, D. S. Kim, M. Merico, A. Padmanabhan, K. H. Hong, M. Schnitzler, U. C. Park, P. H. Gordon, J. Tjandra, D. Rosenthal, B. G. Wolf, M. J. Zinner, R. H. Grace, K. C. Park, A. P. Meagher, C. R. Changchien, B. M. Taylor, O. A. Ogunbiyi, and P. Teniere

Subjects
Convention, Gerontology, medicine.medical_specialty, Surgical oncology, business.industry, Public health, General surgery, Gastroenterology, medicine, General Medicine, business, Colorectal surgery
Published
1996
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3. Epidermal Growth Factor Binding and Action on Tympanic Membranes

Author

Nolph Mb, T G O'Daniel, Zogg J, S C Jones, Gregory S. Schultz, Petitjean M, and Martinez Sa

Subjects
Pathology, medicine.medical_specialty, Tympanic Membrane, Stromal cell, Swine, Wounds, Penetrating, Binding, Competitive, 03 medical and health sciences, 0302 clinical medicine, Epidermal growth factor, Cornea, Epidermal growth factor binding, medicine, Animals, 030223 otorhinolaryngology, Receptor, Wound Healing, Epidermal Growth Factor, business.industry, Histology, General Medicine, Hyperplasia, medicine.disease, Molecular biology, ErbB Receptors, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Cats, Autoradiography, Wound healing, business, hormones, hormone substitutes, and hormone antagonists
Abstract

A significant percentage of tympanic membrane (TM) perforations require some form of therapy to heal. Topical application of epidermal growth factor (EGF), a potent mitogen for epidermal and mesodermal cells, promotes healing of injuries in tissues histologically similar to TM, such as cornea and skin. We evaluated TM as a target tissue for EGF action. Specific, high affinity receptors for EGF were detected in TM (Kd = 3.1 nM, 150 fmol receptor/mg protein). Autoradiography of iodine 125-EGF binding to intact TMs revealed that EGF receptors were present on cells in the stratified squamous epithelial layer and in the stromal/mucoepithelial layer. Repetitive treatment of perforated cat TMs with 20 micrograms of EGF formulated in saline induced substantial hyperplasia of epithelial and stromal layers compared to paired TMs treated with saline. A single treatment of perforated cat TMs with 50 micrograms of EGF formulated in a hydrogel or in shredded Gelfoam produced significantly (p less than .05) smaller perforations at 6 days following the operation compared to paired TMs treated with vehicles. These results demonstrate that TM is a target tissue for EGF and that topical treatment with EGF stimulates healing of TM perforations.

Published
1990
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4. Expression of interleukin-6 by intestinal enterocytes

Author

A. T. R. Axon, Rosamonde E. Banks, J T Whicher, P. D. Howdle, Michael F. Dixon, S. C. Jones, and Ludwik K. Trejdosiewicz

Subjects
Pathology, medicine.medical_specialty, Lipopolysaccharide, medicine.drug_class, Colon, medicine.medical_treatment, Fluorescent Antibody Technique, Biology, Monoclonal antibody, Inflammatory bowel disease, Coeliac disease, Pathology and Forensic Medicine, chemistry.chemical_compound, Intestinal mucosa, medicine, Humans, Intestinal Mucosa, Lamina propria, Interleukin-6, General Medicine, medicine.disease, Inflammatory Bowel Diseases, Small intestine, Intestines, Celiac Disease, Cytokine, medicine.anatomical_structure, chemistry, Immunology, Colitis, Ulcerative, Research Article
Abstract

AIMS--To investigate the cellular source of the cytokine interleukin-6 (IL-6) in the small and large intestines of patients with inflammatory bowel disease, coeliac disease, and in controls. METHODS--IL-6 was detected in frozen sections of bowel by single and double label indirect immunofluorescence using rabbit polyclonal and murine monoclonal anti-IL-6 antibodies. The murine monoclonal antibodies RFDR1 (anti-MHC class II) and UCHT1 (anti-CD3) were used to localise macrophages and T lymphocytes, respectively. Lipopolysaccharide stimulated peripheral blood monocytes were used as positive control cells for IL-6 protein. RESULTS--IL-6 was demonstrated in the small and large intestine of patients with inflammatory bowel disease, coeliac disease, and in controls. The protein was present predominantly in enterocytes and colocytes in normal and inflamed mucosa, but not in the infiltrating inflammatory cells of the lamina propria. There were no discernable differences between patients with inflammatory bowel disease or coeliac disease and controls, nor between small and large bowel mucosa. Incubation of antibody with recombinant human IL-6 protein abolished the labelling. IL-6 protein was also present in lipopolysaccharide stimulated peripheral blood monocytes. CONCLUSIONS--The data suggest that enterocytes and colocytes may play an active part in the immune response of the gut. The presence of IL-6 in both inflamed and non-inflamed small and large intestine requires further investigation into the function of this cytokine in the gut.

Published
1993

5. Bleeding peptic ulcer--endoscopic and pharmacological management

Author

S. C. Jones and A. T. R. Axon

Subjects
Adult, medicine.medical_specialty, Antifibrinolytic, medicine.drug_class, medicine.medical_treatment, Pharmacological management, Peptic Ulcer Hemorrhage, Gastroenterology, Electrocoagulation, Endoscopy, Gastrointestinal, Laser therapy, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Chemotherapy, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Surgery, Endoscopy, Peptic ulcer, Laser Therapy, business, Research Article
Published
1991

6. Fluoridation in Britain today

Author

S C Jones and M A Lennon

Subjects
Gerontology, business.industry, General Engineering, General Earth and Planetary Sciences, Medicine, Library science, General Medicine, business, Research Article, General Environmental Science
Published
1993
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8. REGIONAL BRAIN BLOOD FLOW IN PULSATILE AND NON-PULSATILE CARDIOPULMONARY BYPASS IN SHEEP -A PRELIMINARY STUDY

Author

Kiyotaka Fukamachi, S. C. Jones, Ryuji Kunitomo, K. Nakamura, Charles R. Davies, Tetsuji Matsuyoshi, and Hiroaki Harasaki

Subjects
medicine.medical_specialty, business.industry, Biomedical Engineering, Biophysics, Pulsatile flow, Bioengineering, General Medicine, law.invention, Biomaterials, Cerebral blood flow, law, Internal medicine, Cardiology, medicine, Cardiopulmonary bypass, business
Published
1996
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9. Endodermal Sinus Tumour of the Ovary: The Place of Alphafetoprotein Detection, Surgery and Chemotherapy

Author

S. K. Khoo, I. S. C. Jones, D. Buntine, and P. F. Massey

Subjects
Adult, medicine.medical_specialty, medicine.medical_treatment, media_common.quotation_subject, Improved survival, Antineoplastic Agents, Ovary, Fertility, Disease, Vinblastine, Bleomycin, Antineoplastic Combined Chemotherapy Protocols, Mesonephroma, medicine, Humans, Pathological, Survival rate, media_common, Ovarian Neoplasms, Chemotherapy, business.industry, Obstetrics and Gynecology, General Medicine, Endodermal sinus tumour, Surgery, medicine.anatomical_structure, Drug Therapy, Combination, Female, alpha-Fetoproteins, Cisplatin, business
Abstract

New developments in the management of the rare endodermal sinus tumour of the ovary, together with the reporting of 2 additional patients, are presented. There is a need for accurate clinical and pathological evaluation of the disease. As shown in the present study, histochemical staining for alphafetoprotein (AFP) provides an additional factor in diagnosis, and monitoring of AFP levels in serum is a useful guide to treatment. The prognosis, previously uniformly poor, appears to be improved with the use of multidrug chemotherapy. In a collated series of 98 patients, the 24‐month survival rate was 65% in Stage I disease and 67% in Stage II disease. However, the choice of effective drugs remains uncertain. The improved survival of young patients with aggressive chemotherapy has now raised the question of preservation of fertility at the time of surgery. In a small collated series of 26 patients with Stage I disease, survival to 36 months was not jeopardized by the conservative removal of one tube and ovary. Copyright

Published
1981
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10. EVALUATION OF OVARIAN CHANCER BY SECOr JD-LOOK LAPAROTOMY AFTER TREATMENT

Author

K. Khoo, Ian S. C. Jones Soo, and Sue V. Whitaker

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Management programme, General Medicine, medicine.disease, Surgery, Laparotomy, Second look laparotomy, medicine, Ovarian cancer, business, After treatment
Abstract

In the five-year period 19/75 to 1979, 234 patients entered the Royal Brisbane Hospital Consultative Ovarian Carncer Clinic's management programme. Thirty-six patients were considered suitable for e valuation by a subsequent laparotomy following completion of the treatment programme. The clinic's protocol for second-look surgery and its results are presented. The findings, from the protocol-based surgery were accurate in 23 of 24 patients (96%) on the basis of subsequent follow-up, and surgery was free of complications in 33 of 36 patients (92%). The objectives of management are reviewed, and a recommendation about the timing of surgery is made. In all cases there must be individualization of treatment.

Published
1981
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11. Multiple forms of epileptic attack secondary to a small chronic subdural haematoma

Author

S. C. Jones, J. Heath, N. Bradey, J. M. Bamford, and R. V. Heatley

Subjects
Male, medicine.medical_specialty, Multiple forms, Epileptic attack, Electroencephalography, Chronic subdural haematoma, Epilepsy, Hematoma, Humans, Medicine, Aged, General Environmental Science, medicine.diagnostic_test, business.industry, General Engineering, General Medicine, medicine.disease, Surgery, Hematoma, Subdural, Chronic disease, Chronic Disease, General Earth and Planetary Sciences, business, Complication, Research Article
Abstract

Une observation rare: malade de 75 ans presentant un petit hematome sous-dural dans la region fronto-temporale gauche;. Les seules manifestations cliniques sont des crises epileptiques variees: convulsions, absences, confusion mentale etc.

Published
1989
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13. Progression of vulval carcinoma-in-situ

Author

D. Buntine and I. S. C. Jones

Subjects
Gynecology, medicine.medical_specialty, Invasive carcinoma, Vaginal Neoplasms, Vulvar Neoplasms, business.industry, Carcinoma in situ, Obstetrics and Gynecology, Uterine Cervical Neoplasms, General Medicine, Disease, medicine.disease, Neoplasms, Multiple Primary, medicine, Humans, Female, business, Carcinoma in Situ, Aged
Abstract

Summary: A case of multicentric vulval carcinoma-in-situ which progressed to invasive carcinoma during an 8-year period is presented. Various aspects of this disease are discussed.

Published
1978

14. Ectopic vaginal trophoblast in association with a partial mole

Author

I. S. C. Jones, E. J. Vesey, and D. Buntine

Subjects
Gynecology, Adult, medicine.medical_specialty, Vaginal Neoplasms, business.industry, Uterus, Obstetrics and Gynecology, Trophoblast, General Medicine, Hydatidiform Mole, Trophoblastic Neoplasms, Partial mole, medicine.disease, Hydropic degeneration, medicine.anatomical_structure, Pregnancy, embryonic structures, Uterine Neoplasms, medicine, Humans, Female, business
Abstract

Summary: A case of ectopic vaginal trophoblast in association with a blighted ovum showing hydropic degeneration is presented. This combination satisfied the histological criteria of Szulman and Surti for inclusion as a partial mole. Subsequent follow-up revealed non-progression of the condition. The problems of obtaining a satisfactory classification for proliferative trophoblastic lesions are outlined.

Published
1980

19. Don Carlos Mote

Author

H. H. Crowell, S. C. Jones, and G. R. Ferguson

Subjects
Ecology, Insect Science, General Medicine, Biology, Humanities
Published
1974
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