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Your search keyword '"Lydia Carde"' showing total 2 results
Start Over Author "Lydia Carde" Topic general medicine
2 results on '"Lydia Carde"'

1. ChemInform Abstract: PaaSicats: Powerful Catalysts for Asymmetric Epoxidation of Enones. Novel Syntheses of α-Arylpropanoic Acids Including (S)-Fenoprofen

Author

Lydia Carde, Thomas Geller, Stanley M. Roberts, and Huw M. L. Davies

Subjects
chemistry.chemical_classification, Fenoprofen, Ketone, Chemistry, Enantioselective synthesis, General Medicine, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, medicine, Moiety, Oxidative cleavage, Trimethylaluminium, medicine.drug, Dichloromethane
Abstract

Application of the recently developed silica-adsorbed polyleucine catalysts to the enantioselective epoxidation of two enones is reported. Treatment of these epoxides with trimethylaluminium in moist dichloromethane generates the α-hydroxy-β-methyl-ketones, with inversion of configuration. Diastereoselective reduction of the ketone moiety followed by oxidative cleavage generates α-arylpropanoic acids.

Published
2010

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