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The formation of informal settlements is increasing rapidly, especially in some developing economies such as the Port Harcourt Municipality in Nigeria. These settlements are vulnerable to several urban challenges from natural and anthropogenic disasters, including the recent COVID-19 pandemic. The landscape of Port Harcourt Municipality is inundated with the proliferation of informal urban settlements especially around its southern fringes, which has engendered these settlements to become vulnerable to the vagaries of any occurring disaster such as the COVID-19 pandemic. This study attempts to unfold residents' lived experiences in these informal settlements to get the narratives of their experiences during the COVID-19 pandemic. A total of forty-one (41) informal settlements were identified, out of which three (3) of those settlements (Okrika, Nembe and Ibadan) were selected purposively due to ease of accessibility, safety and spread around the municipality. The study adopted the qualitative approach by applying semi-structured interviews with key informants in these selected informal settlements. A total of nine (9) key informants were selected, with three (3) comprising the head of the community development committee (CDC), Youth and Women representatives from each settlement were interviewed. In addition, photographs of these selected informal settlements were taken to depict the characteristics of those settlements. Content analysis was used to analyse the outcome of the interviews. Some key findings include poor orientation of residents regarding disease spread, no effective urban renewal scheme to improve residents' quality of life, no proper planning of those settlements and residents were not included in the planning of those settlements. This study recommends proper enlightenment of residents regarding the management of disease spread. The provision of sustainable measures that will build resilience and adaptive capacities for the dwellers and continuous urban renewal schemes to ensure the provision of basic social infrastructure that would improve the residents' quality of life. However, the study concludes that the identification and characterisation of informal settlements will provide a better understanding and knowledge of the settlements as a resource to improve the social and economic conditions of the dwellers, distribution of infrastructural facilities and services, and wealth, thereby enhancing the quality of life and wellbeing of the residents and the general urban affairs as this will equally present opportunities for proper urban planning and management.

In recent times the consequences of flooding on farmlands have been majorly attributed to climate change which has contributed to the distortions in the social and economic activities in Rivers State, Nigeria. This study aims to identify adaptive mitigative measures to manage the social and economic impact of farmlands flooding in selected communities in Etche Local Government Area in Rivers State. The objectives include the identification of the significant causes of farmland flooding in the study area, determining the social and economic impacts of farmland flooding in the study area, and identify mitigation measures put in place to combat farmland flooding in the study area. The study adopted the Mixed Methods Research approach using a concurrent triangulation research design. The data sources include questionnaire administration (using a 5-scale Likert Scale), key informant in-depth interviews, personal observation, photographs, and published materials from institutions. A total of 146 questionnaires were administered across these selected communities, including Nihi, Isu and Umuechem. A purposive sampling technique was deployed, and a total of 96 questionnaires were retrieved and validated for analysis. Some of the leading causes of farmland flooding include the blockage of storm-water channels, overgrazing and bush burning, overpopulation due to increased development (structures), heavy rainfall and drainage failure. The study further revealed that the social and economic impacts on farmland, communities and inhabitants are depression, stress, anger, and social vices. Other effects include loss of farmland and produce, increase in goods and services, loss of livelihood system, loss of income and damage to properties. The anticipated mitigative measures by respondents are a collaboration of stakeholders (farmers, communities, and government agencies), warning signals, reconstruction of failed drainages, quick responses, and adequate relief materials. In addition, the study recommended proper education and enlightenment of the vulnerable population on how to avoid the negative consequences of flood disasters. vulnerable people should prepare for any eventuality, real-time data on flood vulnerability mapping of the study area to enable the government, government agencies like the (NIMET) and the vulnerable population to know the extent of flooding and duration of every flooding episode. Furthermore, effective Spatial planning of those vulnerable communities to reduce the negative consequences of flood disaster and afforestation should be encouraged to mitigate adverse impacts of the flood.

The apparent disconnect of different modes of transport in the Port Harcourt metropolis is causing difficulty in urban mobility among commuters. The study has assessed the integration of road and water transport systems to build a sustainable urban environment in Port Harcourt metropolis, Nigeria. The specific objectives of the study are to identify the road and water infrastructure transport systems in Port Harcourt metropolis and their state of functionality, identify and examine the disconnect existing in the street and water transportation in the study area, identify the challenges facing the integration of road and water transportation in the study, and provide physical planning strategy to achieving the integration of road and water transport systems in the study area. The study adopted a Mixed Methods Research (MMR) approach using a concurrent triangulation research design to obtain the relevant data and information that addressed the study aim and objectives of the study. In addition, the study employed purposive and simple random sampling techniques, including the key informant method. A total of four hundred (400) commuters, fifty (50) each, were interviewed from six (6) major road corridors and two (2) jetties in Port Harcourt City (Aggrey, Trans-Amadi and Olu-Obasanjo Roads) and Obio/Akpor (Akpajo-Elelenwo-Oil Mill, NTA and Agip Roads) and two (2) jetties: Port Harcourt City (Bille/Bonny/Nembe Jetty) and Obio/Akpor (Feltaco Jetty). Some Key informants from the transport sector like the Rivers State Ministry of Transport (RSMT) staff Rivers State Ministry of Urban Development and Physical Planning (RSMUDPP). Others are staff of the Rivers State Transport Company (RTC), National Union of Road Transport Workers (NURTW), Rivers State Marine Transport Company, waterways transport operators, and Town Planners were among those interviewed. The study found potential for integrating road and water transport systems in the study area, and some of the infrastructures are obsolete and lack maintenance, thereby impeding interconnectivity and interlinkage between both systems. The study also revealed that government unwillingness to harness and develop the potential poor urban planning and management, and poor urban governance contribute to the disconnect of the road and water transport systems observed, affecting the quality of life and well-being of residents and poor urban sustainability. Thus, to improve the potentials and challenges identified, the study suggested that the government should develop an integrated transportation policy framework to enhance the integration of road and water transport systems. The government should upgrade and rehabilitate roads and water transportation infrastructure to improve intermodal connectivity and linkages for efficiency and effectiveness in the study area. The Public-Private Partnership approach should be developed and adopted in the planning and management of the transport sector in the study area; develop all waterways within the study area through canalisation and channelisation, and the government should adopt sound governance principles to involve all stakeholders of the transport sector.

Wetlands globally contribute to valuable ecosystem services to both natural species habitat and human tourist attractions in any location including those found in Port Harcourt Municipality. Wetlands are also beneficial and significant serving as breeding regions for wildlife and safe spaces for sea creatures, support a diversity of species and provide some climate restraining components, characteristic of any natural habitat. This study highlights some resilient responses residents put up in the aftermath of wetland reclamation and conversion in neighbourhoods. The study aims to ascertain the environmental and physical challenges of wetland loss on the wetland dwellers and subsequently identify resilient paradigms adopted to cope with such associated stress. Forty-one wetland settlements were identified within the Port Harcourt municipality and three out of those settlements were chosen purposively. A total of 293 questionnaires were distributed and SPSS was used to analyse the data. ERDAS Imagine 2014 version was used to show spatial changes between the years 1986 to 2000, and 2000 to 2016. The study shows that from 1986 to 2000, Port Harcourt municipality lost a total of 1,255,500m2. This translates to a 5% loss with an average rate of 89,678.57m2 per annum. Between 2000 and 2016, the rate of loss was 108,956.25m2 per annum, and approximately 7.69% of wetlands totalling 1,743,300m2 were lost to urbanisation and other activities. The result indicates that some of the challenges of wetland loss include flooding, poor refuse disposal system, and unplanned settlements. Indigenous knowledge, social capital and symbolic power are some of the resilient responses displayed by the vulnerable population to build resilience capacities. The study recommends periodic mapping of all wetlands and an effective development control framework to monitor incursions into existing wetlands.

The study aimed to assess the dynamics of land use changes in the urban environment of Yenagoa City, Nigeria as to understand the changes, consequences and ameliorate the changes. Objectives of the study are to determine land use changes that are evident in the study between 1996 to 2020; identify and assess the causes and dynamics of the land use changes that are evident in the study area; ddetermine the consequences of land use changes in the urban environment of the study area; and provide physical planning measures to monitor, control and manage land use changes in Yenagoa City to promote the sustainable urban environment. The study employed a Mixed Methods Research approach of concurrent triangulation and longitudinal research designs for the collection and analyses of data in the study. The study also employed remote sensing technique, Geographic Information Systems, and time series analysis techniques to collect and analyse data for the study. Stratified and simple random sampling techniques were employed for the collection of data. A total of 9 communities were chosen and sampled and 396 respondents (households) were determined and interviewed as sample size using the Taro Yamane formula. Key informants from government agencies and professionals were interviewed using their responses as themes and concepts for content analysis. The study revealed that there are significant land-use changes such as water bodies, vegetation, and built-up areas between 1996-2020. The study also identified population increases and the demand for land for urban development. The study also identified the dynamics that have caused these changes including an increase in the household size, nearness to the workplace, improve security, cheap rent, increase in migrants, employment opportunities and lack of implementation of the development plan. The consequences identified by the study include constant changes in water bodies, vegetation and built-up areas, the prevalence of flooding, encroachment to marginal lands, slum and squatter development, constant pollution, and modification of the social environment. The study recommends that; to achieve a sustainable urban development including the Yenagoa Master Plan of 2004 should be reviewed and implemented guide, control and manage urban land-use changes, the establishment of an urban land-use framework that will foster synergy of all physical planning agencies and institutions, planning and re-planning of new neighbourhoods and existing communities, continuous urban studies of land-use and environment management and encourage citizen education and participation in environmental management in the city.

Recently, there has been a notably increased use of microwave energy for heating and processing foods particularly in catering services and in our homes owing to its speed, convenience and efficiency compared to the traditional heating method. Due to the availability and affordability of plastic containers, they are mostly used to contain foods for preheating in a microwave. However, these plastics pose great risk on humans’ health if they get scratched or heated, and leach out chemicals into the contained foods. Also, the microwave energy has been speculated to have posed risks to the health of humans considering the electromagnetic radiations it emits. This study was aimed at evaluating the effect of ingested foods preheated (with microwave) in plastic containers on the reproductive profile of male albino rats. A total of twenty-four (24) male albino rats weighing between 120 to 200 g were used for this study. The rats were divided into three (3) groups (group I, II and III) of eight (8) rats per group. The rats were fed ad libitum with porridge beans and jellof rice with meat and fish daily for 40 days. The foods ingested by group I rats were not preheated in a microwave; the foods ingested by group II rats were put in ceramics and preheated in a microwave for 2 minutes daily; while the foods ingested by group III rats were put in plastic containers (not labeled as ‘‘microwave safe’’) and preheated in a microwave daily for 2 minutes. After an overnight fast, the rats were anaesthetized using chloroform, and blood samples obtained (via cardiac puncture) were used to analyze serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone using the ELISA method. The epididymis was also excised and immediately macerated to obtain semen, which was used for semen analysis. The results obtained showed a significantly decreased (p

This research was to evaluate the quality of life of the urban dwellers in Yenagoa, Amarata and Ekeki cities to ascertain if there is a decline in the quality of life residents in those selected neighbourhoods with a view to highlight such causal factors. The study adopted the Passive-Observational survey design such that the research respondents were observed in-situ without experimental manipulation. The research population was purposively drawn, and data was drawn from primary and secondary sources. Objective and subjective dimensions of quality of life were viewed in the form of physical, social and economic domains were assessed with emphasis on the type of housing, recreational preferences and employment status of respondents. Findings indicate that the quality of life of residents in Yenagoa, Amarata and Ekeki has progressively declined from when Yenagoa was a local government headquarters to becoming a capital city of an oil and gas producing state. As evident, the predominant housing type is rooming housing that does not befit its status, with limited recreational space and a phenomenal 45% unemployment rate. Findings further depict a bleak and rapidly declining quality of life of residents. The study recommends that there should be deliberate government intervention to improve housing conditions, provision of adequate functional recreational facilities that would enhance social interaction and physical wellbeing. There should be deliberate government policy with the requisite framework to stimulate industrial growth to reduce the phenomenal unemployment were recommended.

Building resilience capacities to survive flood disasters in vulnerable communities in the global south encompasses techniques that are unique to such communities. These strands of unique techniques are embedded in their indigenous knowledge as a people and revealed through the actions they display during such times of disaster. Data was obtained from four communities in the Orashi region in the aftermath of the 2012 floods in Nigeria, to investigate the techniques and actions adopted to help build local resilience capacity amongst vulnerable communities there. Interviews and focus groups were the primary means of data collection and analysis was done qualitatively. The findings revealed five key attributes the communities possessed that enabled them build their resilience capacity to cope with the flood disaster.

Background: Pregnancy is a physiological condition in which the uterus of a woman carries at least one embryo for about 38 weeks, from conception to delivery; during this period, several physiological changes in biochemical and haematological functions occur. Knowledge of these changes however, may be helpful in providing effective care for pregnant women; hence this study was aimed at evaluating the effect of gestational periods on lipid profile, plasma glucose and chromium levels of apparently healthy pregnant women in Port-Harcourt, Nigeria.Methods: A total of 200 apparently healthy women were used for the study; 150 of them were pregnant (50 in the first trimester, 50 in the second trimester, and 50 in the third trimester), and the remaining 50 women were not pregnant. They were divided into four (4) groups; group I (control group) consists of 50 non-pregnant women, group II consists of 50 pregnant women in their first trimester, group III consists of 50 pregnant women in their second trimester, while group IV consists of 50 pregnant women in their third trimester. About 8 ml of fasting venous blood was collected from the antecubital fossa of each subject; 3 ml was dispensed into a fluoride oxalate anticoagulant bottle for the determination of plasma glucose concentration. The remaining 5 ml was dispensed into a lithium heparin-anticoagulant bottle for the determination of chromium and lipid profile. The data were analyzed using the one-way analysis of variance (ANOVA) and Tukey multiple comparison test.Results: The results showed a significant decrease (p

Heavy metals gain entry into biological systems mainly via inhalation and ingestion, and also via radiation or radio-therapeutic measures. The accumulation of these heavy metals in biological systems overtime may cause several deleterious health challenges such as liver, kidney and brain damages amongst others. Intoxication with heavy metals may either be acute or chronic, and because the kidney has the ability to reabsorb and accumulate divalent metals, it happens to be the primary target organ for heavy metal toxicity, inducing renal damage. The extent of this damage depends on the dose, nature, route and duration of exposure to the metal. Chronic kidney disease (CKD) is characterized by a permanent loss of nephrons accompanied by an eventual decline in glomerular filtration rate (GFR); this (to a greater extent) maybe due to heavy metal intoxication and the renal reabsorption of these heavy metals. Although 70 percent of the heavy metals are reabsorbed in the proximal tubule, all segments of the nephrons are involved in the reabsorption of these metals, where several transporters such as the Divalent Metal Transporter (DMT)-1, Na+/amino acid co-transporter, Zinc Transporter (ZnT)-1 and stretch-activated cation channels (SAC) facilitate the reabsorption. In the nephrons of each kidney, heavy metals are primarily reabsorbed via the apical membrane and accumulate at the basolateral membrane; these heavy metals do not readily exit the basolateral membrane, which overtime may result in chronic inflammation of the nephrons, fibrosis and kidney failure. However, the loss of nephrons and decline in GFR in CKD are compensated by certain changes (glomerular and cellular, enhanced renal blood flow, enhanced single nephron glomerular filtration rate and tubular hypertrophy) in the remaining functional nephrons. These changes help to deliver solutes to the remaining functional nephrons for uptake by the epithelial cells of the renal tubules. Also, because the luminal and basolateral surfaces of tubular epithelial cells of the remaining healthy nephrons are also potentially exposed to higher levels of metabolic wastes, xenobiotics, heavy metals and other nephrotoxicants, renal injury, tubular or glomerulosclerosis, and death of these nephrons occur. These compensatory changes become insufficient once about 75 percent of the nephrons are no longer functional and incapable of maintaining homeostasis and renal function. This results in the accumulation of metabolic wastes in the blood, and induction of metabolic disturbances and/or organ intoxication.

Rivers generally have been source of livelihood for several persons in both developed and developing countries, and the rivers have been exploited without recourse to the consequences of this action by those involved. The aim of this research is to assess the social and economic consequences of sand mining on communities along the Victory River. The objectives are to: examine residents’ perception, identify the impacts of sand mining in their domain and propose mitigation measures for moderate and major negative impacts and enhancement measures for positive impacts of sand mining. Hazards and effects management process (HEMP) was used identify the impacts of sand mining on the communities and propose mitigation measures for moderate and major negative impacts and enhancement measures for positive ones. The study adopted multistage sampling technique by identifying all the communities along the Victory River and purposively four (4) communities were selected for the study. Mixed methods were used to collect data with one-hundred and twenty-three (123) structured questionnaires and key informant interviews. The study found that continuous river sand mining had altered the river courses and increased the width and depth of the Victory River. Livelihood chain of the people have been distorted leading to diminished purchasing power, increased poverty level and other associated social vices. There were also identified socio-economic benefits like employment and revenue generation for the communities. The study recommends that: river channel cross sections should be benchmarked using aerial photographs and periodic hydrographic survey, effective social management plan and enhancement measures be taken, enforcement of relevant laws to control the activities of sand miners and their host communities alike.

Community participation has been identified as effective driver of rural development in emerging economies while community development committees (CDCs) are key players in implementing rural development programmes in communities. The study aims at assessing the level of participation of communities and community development committees in the provision of public infrastructure in selected communities of Abua/Odual Local Government Area in Rivers. The objectives are to: identify existing mechanism for public participation in rural development process; ascertain the nature and extent of participation in rural development, ascertain the participation level of Community Development Committee (CDC) in implementation of development projects. A cross-sectional study that engaged multistage sampling technique was adopted. Primary and secondary data were collected, analysed and represented with charts, percentages and tables. One hundred (100) respondents were purposively drawn from Otari, Odaga and Omalem communities and stratified sampling was applied to administer questionnaire, only heads of households and members of community development committees formed the respondents. The study found out among other things; that the community development committees (CDCs) in the respective communities were effective in the dissemination of information with respect to projects embarked upon by the government to encourage community participation; there is a dearth of information and lack of synergy between the government agencies charged with the responsibility of planning and implementing rural development policies and the beneficiaries of such development; no Local Planning Authorities at the local government areas. The study recommended that members of the CDCs should form part members of planning and implementation committees in their respective communities, immediate establishment of local planning authorities.

Made available in DSpace on 2022-04-28T19:41:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-31 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Snakebite envenoming is the cause of an ongoing health crisis in several regions of the world, particularly in tropical and neotropical countries. This scenario creates an urgent necessity for new practical solutions to address the limitations of current therapies. The current study investigated the isolation, phytochemical characterization, and myotoxicity inhibition mechanism of gallic acid (GA), a myotoxin inhibitor obtained from Anacardium humile. The identification and isolation of GA was achieved by employing analytical chromatographic separation, which exhibited a compound with retention time and nuclear magnetic resonance spectra compatible with GA's commercial standard and data from the literature. GA alone was able to inhibit the myotoxic activity induced by the crude venom of Bothrops jararacussu and its two main myotoxins, BthTX-I and BthTX-II. Circular dichroism (CD), fluorescence spectroscopy (FS), dynamic light scattering (DLS), and interaction studies by molecular docking suggested that GA forms a complex with BthTX-I and II. Surface plasmon resonance (SPR) kinetics assays showed that GA has a high affinity for BthTX-I with a KD of 9.146 × 10−7 M. Taken together, the two-state reaction mode of GA binding to BthTX-I, and CD, FS and DLS assays, suggest that GA is able to induce oligomerization and secondary structure changes for BthTX-I and -II. GA and other tannins have been shown to be effective inhibitors of snake venoms' toxic effects, and herein we demonstrated GA's ability to bind to and inhibit a snake venom PLA2, thus proposing a new mechanism of PLA2 inhibition, and presenting more evidence of GA's potential as an antivenom compound. Instituto de Genética e Bioquímica Universidade Federal de Uberlândia UFU Departamento de Biofísica e Farmacologia Instituto de Biociências Universidade Estadual Paulista UNESP Laboratório de Biotecnologia de Proteínas e Compostos Bioativos LABIOPROT Centro de Estudos de Biomoléculas Aplicadas à Saúde CEBio Laboratório de Imunologia Celular Aplicada à Saúde Fundação Oswaldo Cruz FIOCRUZ Unidade Rondônia Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis IBAMA Departamento de Química Universidade Federal de Lavras UFLA Instituto Federal Goiano IF Goiano Faculty of Chemical Sciences University of Cuenca LAQV/Requimte Faculty of Sciences University of Porto Centro Universitário São Lucas UniSL Instituto Nacional de Ciência e Tecnologia em Epidemiologia da Amazônia Ocidental (INCT-EpiAmO) Departamento de Biofísica e Farmacologia Instituto de Biociências Universidade Estadual Paulista UNESP