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Your search keyword '"I. O. Chikileva"' showing total 3 results
Start Over Author "I. O. Chikileva" Topic general medicine
3 results on '"I. O. Chikileva"'

1. Immunosuppression in sepsis and possibility of its correction

Author

M. V. Kiselevskii, S. M. Sitdikova, A. G. Abdullaev, S. A. Shlyapnikov, and I. O. Chikileva

Subjects
0301 basic medicine, medicine.medical_specialty, immunosuppression, RD1-811, business.industry, medicine.medical_treatment, 030208 emergency & critical care medicine, Immunosuppression, General Medicine, Immunotherapy, medicine.disease, Sepsis, sepsis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Antibiotic therapy, medicine, antibiotic therapy, Surgery, immunotherapy, Intensive care medicine, business
Abstract

Literature review is devoted to immunosuppression in sepsis and possibilities of its correction.

Published
2018

2. Antiproliferative Activity of a New Nitrosyl Iron Complex with Cysteamine in Human Tumor Cells In Vitro

Author

I O Chikileva, Z S Smirnova, O S Zhukova, and M. V. Kiselevskii

Subjects
0301 basic medicine, Methyltransferase, DNA Repair, Cell Survival, Cysteamine, Iron, Gene Expression, Antineoplastic Agents, Apoptosis, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Basal (phylogenetics), chemistry.chemical_compound, 0302 clinical medicine, Coordination Complexes, Cell Line, Tumor, Cytotoxic T cell, Humans, DNA Modification Methylases, Caspase, Cell Proliferation, biology, Dose-Response Relationship, Drug, Tumor Suppressor Proteins, General Medicine, In vitro, 030104 developmental biology, DNA Repair Enzymes, chemistry, Biochemistry, Cell culture, A549 Cells, Organ Specificity, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Nitrogen Oxides, K562 Cells
Abstract

We studied cytotoxic activity of a new NO-releasing tetranitrosyl binuclear iron complex with cysteamine (CysAm) for human tumor cells, the relationship between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and cell sensitivity to CysAm, and apoptosis-inducing capacity of this preparation. It was found that histogenetically different cell lines are characterized by different sensitivity to CysAm, and this parameter correlated with the basal level of MGMT. CysAm induced apoptosis via activation of caspases 3 and 7. These data suggest that CysAm can be considered as a potential antitumor agent, but definitive conclusions can be made after preclinical trials.

Published
2016

3. Effect of recombinant heat shock protein 70 of mycobacterial origin on cytotoxic activity and immunophenotype of human peripheral blood mononuclear leukocytes

Author

M. V. Kiselevskii, I. O. Chikileva, D. S. Vorobiev, and I. B. Semenova

Subjects
hemic and immune systems, General Medicine, Mycobacterium tuberculosis, Biology, CD16, Molecular biology, General Biochemistry, Genetics and Molecular Biology, In vitro, Monocytes, Recombinant Proteins, Hsp70, law.invention, Immunophenotyping, law, Heat shock protein, Immunology, Recombinant DNA, Cytotoxic T cell, Humans, IL-2 receptor, Heat-Shock Proteins
Abstract

Recombinant heat shock protein of mycobacterial origin with a molecular weight 70 kDa in concentration 0.1 microg/ml in vitro activates cytotoxic activity of mononuclear lymphocytes from peripheral blood of healthy donors against K-562 human erythroblastic leukemia cells sensitive to natural killers. In other concentrations (1.0 microg/ml and 10 microg/ml) this heat shock protein did not significantly affect functional activity of mononuclear leukocytes. Expression of CD4, CD25, CD16 and CD56 on membrane of mononuclear leukocytes was also studied.

Published
2009

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