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Epilepsy is a common neurological disorder characterized by hyperexcitability in the brain. Its pathogenesis is classically associated with an imbalance of excitatory and inhibitory neurons. Calretinin (CR) is one of the three major types of calcium-binding proteins present in inhibitory GABAergic neurons. The functions of CR and its role in neural excitability are still unknown. Recent data suggest that CR neurons have diverse neurotransmitters, morphologies, distributions, and functions in different brain regions across various species. Notably, CR neurons in the hippocampus, amygdala, neocortex, and thalamus are extremely susceptible to excitotoxicity in the epileptic brain, but the causal relationship is unknown. In this review, we focus on the heterogeneous functions of CR neurons in different brain regions and their relationship with neural excitability and epilepsy. Importantly, we provide perspectives on future investigations of the role of CR neurons in epilepsy.

Due to the long time in vehicular cabins, people have high exposure to the airborne volatile organic compounds (VOCS), which will lead to negative effects on human health. In order to analyze the influencing factors of in-car VOCS pollution concentrations, 38 taxis were investigated on the static and closed conditions. The interior air of taxis was collected through activated Tenax adsorption tubes, and the air samples were analyzed with thermally desorbed gas chromatograph. The average concentrations of in-car benzene, toluene, ethylbenzene, xylenes, styrene, butyl acetate, undecane, and total VOCS (TVOC) were 82.7, 212.3, 74.7, 182.3, 24.7, 33.5, 61.3, and 1,441.7 μg/m(3), respectively. Furthermore, the VOCS and TVOC concentrations increase with the rise of in-car temperature and relative humidity, and decrease with the increase of car age and total mileage. In addition, the VOCS and TVOC concentrations are higher in vehicles with small cabins than in ones with big cabins, and change with different sampling sites and various vehicular grades. Finally, according to the multiple linear regression analysis and hierarchical cluster analysis, car age is the most important factor influencing airborne VOCS and TVOC pollution concentrations in vehicular cabins, followed by interior temperature and total mileage.

Sixty three glass fiber reinforced concrete (GFRC) beam specimens of size 100×100×400 mm were tested under four-point flexural fatigue loading by electro-hydraulic universal testing system (MTS) to obtain the fatigue-lives of GFRC at various stress levels. The specimens incorporated 0.6%, 0.8% and 1% glass fiber volume fraction. The results indicate that the statistical distribution of fatigue-life of GFRC is in agreement with the two-parameter Weibull distribution. The coefficients of the fatigue equation have been determined corresponding to different survival probabilities so as to predict the flexural fatigue strength of GFRC for the desired level of survival probability.

The configuration sizes of multi-layer microchannel heat sink is optimized in order to enhance the performance of the high flux chip, which is 556W/cm2. Taking the thermal resistance and the pressure drop as goal functions, a double-objective optimization model was proposed based on the thermal resistance network model. The opimized microchannel heat sink is numerically simulated by computational fluid dynamics (CFD) software. The number of microchannel in width n1 and that in height n2 are 24 and 2, the width of optimized optimized microchannel and fin are 196 and 50 μm, respectively, and the corresponding total thermal resistance of the whole microchannel heat sink is 0.4025 °C/W. The highest temperature is less than 98°C, which can satisfy the requirement of chip to temperature. The maximum temperature difference is 77.8673°C, and the transferred power of heat flux is 200W, so the total thermal resistance is 0.3893 °C/W, which agrees well with the analysis result of thermal resistance network model.

Heat treatment is one method to improve mechanical properties of metal, but each heat treatment method has its advantages and disadvantages, therefore, different requirements regarding size, shape, and properties with respect to different heat treatment processes should be considered. The traditional liquid quenchant are clear water and quench oil. Gas quenching is a relatively new process with several important advantages, such as minimal environmental impact, clean products, and ability to control the cooling locally and temporally for best product properties. To meet the high cooling rates required for quenching, the cooling gas must flow at very high velocities, but still the cooling capacity of gas is weakness. In order to increase the cooling capacity of gas, the spray water is added during gas quenching. In this paper, the GCr15 steel is as the research object, the cooling capacity of clear water, quench oil, nitrogen and nitrogen-spray water are studied through comparison of temperature difference and cooling velocity of the specimen.

At present, for topological optimization in multiple load cases, many researchers use directly traditional Evolutionary Structural Optimization (ESO) method to get respectively the inefficient material set that should be removed in each load case, then the intersection of all the sets is just the material that should be removed. This Multiple Load Cases Traditional ESO (MLCTESO) is difficult to optimize a structure subject to complex load cases, and the optimization result may not be reasonable. Modified Rejection Ratio for Multiple Load Cases Evolutionary Structural Optimization (MRR-MLCESO) proposed in this paper makes a change based on the MLCTESO. The major change is to modify the rejection ratio of each load case according to the ratio of the total strain energy of a structure subject to each load case to the total strain energy of a structure subject to all load cases, then optimization for a structure subject to complex multiple load cases can be easily made and the structure obtained from such an optimization has a good undertaking force performance.

Heat treatment is one method to improve mechanical properties of metal, but each heat treatment method has its advantages and disadvantages, therefore, different requirements regarding size, shape, and properties with respect to different heat treatment processes should be considered. Gas quenching is a relatively new process with several important advantages, such as minimal environmental impact, clean products, and ability to control the cooling locally and temporally for best product properties. To meet the high cooling rates required for quenching, the cooling gas must flow at very high velocities. The phase transformation will occur during quenching. The phase composition will influence the mechanical properties of metal. Consequently, the computation of phase composition is important for the mechanical properties of metal after quenching. In this paper, the mathematical model of phase composition computation was created based on phase transformation kinetics, The phase composition of T10 steel during gas quenching was calculated.

Interior air environment and health problems of vehicles have attracted increasing attention, and benzene homologues (BHs) including benzene, toluene, ethylbenzene, xylenes, and styrene are primary hazardous gases in vehicular cabins. The BHs impact on the health of passengers and drivers in 38 taxis is assessed, and health risk equations of in-car BHs to different drivers and passengers are induced. The health risk of in-car BHs for male drivers is the highest among all different receptors and is 1.04, 6.67, and 6.94 times more than ones for female drivers, male passengers, and female passengers, respectively. In-car BHs could not lead to the non-cancer health risk to all passengers and drivers as for the maximal value of non-cancer indices is 0.41 and is less than the unacceptable value (1.00) of non-cancer health risk from USEPA. However, in-car BHs lead to cancer health risk to drivers as for the average value of cancer indices is 1.21E-04 which is 1.21 times more than the unacceptable value (1.00E-04) of cancer health risk from USEPA. Finally, for in-car airborne benzene concentration (X, μg/m(3)) to male drivers, female drivers, male passengers, and female passengers, the cancer health risk equations are Y = 1.48E-06X, Y = 1.42E-06X, Y = 2.22E-07X, and Y = 2.13E-07X, respectively, and the non-cancer health risk equations are Y = 1.70E-03X, Y = 1.63E-03X, Y = 2.55E-04X, and Y = 2.45E-04X, respectively.

The project involved in this paper is a single-tower double-cable-plane bridge, and the gulf nearby the bridge is in a typical typhoon-affected zone. Therefore, modal analysis of the cable-stayed bridge should be carried out. In this paper, based on the structural vibration theory and the theory of finite element model (FEM) , the space FEM model of the cable-stayed bridge are established with APDL — ANSYS Parametric Design Language. Vibration mode and its frequency can be concluded by the calculating of the cable-stayed bridge's FEM model.