1. Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery
- Author
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Thomas U. Marron, Matthew D. Galsky, Bachir Taouli, Maria Isabel Fiel, Stephen Ward, Edward Kim, David Yankelevitz, Deborah Doroshow, Emma Guttman-Yassky, Benjamin Ungar, Saurabh Mehandru, Benjamin J. Golas, Daniel Labow, John Sfakianos, Sujit S. Nair, Dimple Chakravarty, Michael Buckstein, Xiaoyu Song, Effi Kenigsberg, Sacha Gnjatic, Brian D. Brown, Joseph Sparano, Ashutosh Tewari, Myron Schwartz, Nina Bhardwaj, and Miriam Merad
- Subjects
Clinical Trials as Topic ,Neoplasms ,Drug Discovery ,Humans ,Antineoplastic Agents ,Breast Neoplasms ,Female ,General Medicine ,General Biochemistry, Genetics and Molecular Biology ,Article ,Neoadjuvant Therapy - Abstract
Window-of-opportunity trials, during which patients receive short-duration pre-surgical therapies, provide a platform for understanding the therapies’ mechanisms of action, but will require a paradigm shift in trial design, specimen collection and analysis.
- Published
- 2022