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1. Evaluation of the analytical performances of a portable, 18-parameter hemometric system using capillary blood samples for blood donor enrolment

Author

M. Miceli, D. Patti, P. Iudicone, E. Mannella, Luca Pierelli, and F. Zennaro

Subjects
Blood Specimen Collection, medicine.medical_specialty, Platelet Count, business.industry, Capillary action, Blood count, Blood Donors, Hematology, General Medicine, Reference counter, blood donations, capillary blood counts, portable blood cell analyzer, Blood Cell Count, Surgery, Blood donations, Apheresis, Blood donor, Humans, Medicine, DONOR EVALUATION, business, Biomedical engineering
Abstract

Background and Objectives Blood donor enrolment process is frequently based on the sole capillary haemoglobin (Hb) evaluation while platelet donors by apheresis also requires platelet (Plt) count. The ‘sole Hb’ approach prevents a complete donor evaluation and does not allow Plt donor enrolment. To extend blood counts before donations, we evaluated the performances of a multiparametric counter using capillary blood. Materials and Methods The ABX Micros 60 (Micros 60) blood analyzer was employed on capillary blood and compared with venous counts by a reference counter (Coulter AcT 5diff) in a first series of 416 donors and in a second series of 136, after a 3-month period of routine use of this study counter. An average of 50 μl of capillary blood was collected whose 10 μl had been aspirated by Micros 60. Results High correlations were found between capillary counts using Micros 60 and venous counts using the reference counter. Mean Plt counts differed of 37 × 109/l less for capillary approach in the first series of comparisons, but decreased to 10 × 109/l less in the second series due to a greater expertise of operators in capillary sampling. All other parameters were accurate and never reached clinical relevance albeit they showed statistically significant differences. Conclusion Data on Micros 60 demonstrated that capillary predonation counts may represent a feasible and effective approach to realize an accurate enrolment process of blood and Plt donors.

Published
2010
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2. Meeting abstracts

Author

A. Agnifili, P. Gola, S. Guadagni, R. Verzaro, G. Carducci, F. Gianfelice, I. Ibi, M. Marino, E. Mancini, G. De Bernardinis, C. Allegri, F. Spoletini, V. Mariotti, A. Vari, U. Polinari, D. F. Altomare, E. Brienza, M. Rinaldi, R. Vicente-Prieta, V. Memeo, F. Bertolino, B. Ceccopieri, P. G. Nasi, V. Porcellana, R. Mattio, S. Forconi, M. Dellepiane, V. Biccari, M. Tedesco, A. M. Matrone, I. Sirovich, V. Nicolanti, S. Stipa, U. Bonalumi, R. Galleano, A. Baiardi, P. Balbi, G. Simoni, G. Calleri, V. Casaldi, M. Cosimelli, D. Giannarelli, C. Botti, E. Mannella, G. Wappner, R. Cavaliere, V. Casale, P. Fracasso, A. Grassi, R. Lapenta, V. Stigliano, A. M. Cianciulli, S. Antonaci, C. Greco, G. M. Gandolfo, C. Coco, A. Giordano, G. Roncolini, C. Mattana, R. Coppola, P. Magistrelli, C. Crespi, A. M. De Giorgio, A. Giuliani, V. Galasso, S. Truglia, F. De Ligio, S. De Ligio, L. Serafino, R. Limiti, G. Arrabito, G. Palumbo, G. Pantaleoni, V. D'Alessandro, D. Ranalletta, R. Fanini, C. Huscher, S. Chiodini, F. Zamboni, M. Montorsi, C. Marchese, L. Locatelli, C. Mareni, D. Scaglione, M. Vanzetti, D. Mascagni, G. Di Matteo, K. Hojo, Y. Moriya, K. Sugihara, B. Massidda, A. Nicolosi, A. Tarquini, G. Natalini, F. Borgognoni, S. Ranieri, M. Menculini, G. Carioni, M. Caporossi, C. Huguet, L. Chiavellati, A. Cavallaro, R. Pietroletti, G. Cianca, R. Barnabei, M. Simi, G. Romano, A. Di Carlo, A. Mariano, G. Rotondano, V. Macchia, G. B. Secco, R. Fardelli, S. Zoli, C. Lapini, A. Cariati, C. Prior, I. Sironi, G. Mietti, B. A. Arisi, G. C. Ferrari, M. Gasbacortat, R. Brusamolino, D. Bauer, A. Russo, C. Spinelli, P. Berti, L. Gori, G. Materazzi, M. Mucci, S. Pierallini, P. Miccoli, M. Cosimeili, S. Valabrega, G. Pozzi, R. De Angelis, F. D'Angelo, M. Indinnimeo, P. Aurello, P. Tabbi, G. Fegiz, P. Venezia, R. Colella, M. V. Pitzalis, M. Pitzalis, G. Vuolo, L. Di Cosmo, L. Grimaldi, C. Maglio, D. Masellis, and A. Carli

Subjects
Gastroenterology, General Medicine
Published
1994
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3. American Society of Colon and Rectal Surgeons 91st Annual Convention Podium and Poster abstracts

Author

G. C. Zenni, A. Ramos, S. Hull-Boiner, J. Fleshman, E. Cortesi, H. Harada, D. N. Armstrong, C. Nezhat, L. Capussotti, K. Suzuki, C. A. Walters, J. L. McCue, T. J. Saclarides, H. Brevinge, Patrick S. Ramsey, M. J. Solomon, C. Czyrko, Norma Daniel, V. A. Wolfe, A. J. Senagore, P. H. Gordon, D. C. C. Bartolo, R. Reiss, M. A. Luchtefeld, T. K. Schroeder, M. Trollope, J. M. Church, P. J. Holdsworth, A. Araujo, K. A. Easley, M. R. Moran, K. Hase, R. R. Dozois, P. S. Edelstein, R. D. Fry, P. M. Sagar, Heidi Nelson, I. Nudelman, M. Viamonte, H. Emsellem, G. Feifel, J. W. Milsom, Robert D. Riether, M. W. Arnold, W. E. WiseJr., F. J. Harford, H. Gutman, C. N. Ellis, S. M. Goldberg, M. G. Havenith, P. A. Cole, L. Petty, N. J. Birch, A. F. Brading, G. S. Duthie, T. Fukushima, E. W. Martin, G. B. Morandi, J. Braidt, K. Hacker, A. Sugita, N. S. Williams, K. Abraham, J. Konsten, T. L. Hull, D. Giannarelli, Walter Kikendall, G. J. LaValle, W. A. Koltun, P. L. Roberts, P. R. Williamson, B. M. Boman, D. Mascagni, P. A. Volpe, F. Michelassi, R. Saad, N. Davies, P. N. Ray, A. I. Neugut, T. Eisenstat, David Wingate, J. R. Oakley, B. Mitmaker, U. Hildebrandt, E. G. Balcos, G. E. Block, I. Bayer, A. E. Timmcke, S. M. Thompson, Z. Cohen, M. Tedesco, H. C. Kuijpers, J. Kewenter, C. L. Simmang, B. Bapat, D. A. Owen, R. E. Perry, Donald A. Peck, E. Haglind, A. D. Gulledge, James A. Sheets, M. Swash, Aaron Cohen, S. Schneebaum, W. G. Lewis, J. M. N. Jorge, John Parker, R. W. Golub, M. P. Bubrick, P. S. Aguilar, T. Schmid, I. Perkash, E. Salvati, P. Huth, J. Farmer, B. E. Diamond, S. L. Schmitt, R. McLeod, J. B. J. Fozard, G. Binter, D. R.E. Johnson, R. J. Davie, M. A. Christensen, C. Mojizisik, L. E. Smith, C. N. Elles, R. Bleday, P. A. Brantley, K. A. Forde, P. Willard, T. Yamanouchi, K. D. Gillespie, A. D. Spigelman, John J. Stasik, L. F. Sillin, Bard Cosman, M. T. Ott, E. Edwards, E. Lee, J. Heine, W. D. Wong, R. M. Devine, G. H. Slagle, J. M. MacKeigen, P. W. Marcello, B. Clements, H. Kynaston, P. Paul, E. Wang, W. E. Longo, F. Nezhat, R. D. Madoff, A. M. VernavaIII, T. G. Perry, D. J. Coyle, Jose G. Guillem, H. R. Bailey, M. L. Corman, K. James, S. Heymen, N. J. Mortensen, Devinder Kumar, S. A. Strong, I. C. Lavery, D. Kahn, J. C. Roberts, Eileen Sutter, E. McGannon, M. R. B. Keighley, W. L. AmbrozeJr., G. Morey, T. Wengert, D. Young, G. Y. Lauwers, B. A. Orkin, C. E. Christenson, W. E. Enker, P. Lechner, B. Orkin, M. E. Abel, B. Limberg, S. Galandiuk, R. Rubin, M. A. Tissaw, Irving M. Richman, Leonard L. Gunderson, D. A. Fenney, J. Cole, Brian M. Taylor, J. B. Gathright, P. P. Da Pian, T. H. Dailey, A. Berens, R. Fry, E. Pennington, R. D. SminkJr., Indru T. Khubchandani, J. A. Coller, O. B. Johansen, P. Paty, K. McKenna, V. M. Stolfi, P. M. Falk, S. C. Sessions, J. M. Anderson, Joseph Kokoszka, J. G. Williams, J. Wong, K. C. R. Farmer, A. A. Deutsch, K. S. Khanduja, H. W. Johnson, S. Y. Leu, D. Johnston, L. Gottesman, Y. S. Y. Chiu, K. Arai, R. J. Staniunas, R. S. Scoma, J. MacFie, Phyllis E. Bowen, M. Nino-Murcia, B. A. Kerner, J. Yates, E. Birnbaum, D. Franceschi, T. Pritchard, B. A. Taylor, H. Hsu, I. Kodner, J. A. Heine, G. L. Casillas, Robert W. Beart, E. M. McGannon, C. Tirelli, E. T. Goldstein, G. J. Weiner, N. C. Gupta, M. C. Veidenheimer, A. G. Thorson, S. A. Jenkins, P. Hartendorp, H. Tulchinsky, P. Shellito, P. B. Soeters, W. D. Buie, M. L. Eckhauser, G. R. Johnston, L. W. Lin, K. M. O'Toole, R. K. S. Phillips, Juan J. Nogueras, W. Reiter, Y. Moriya, R. T. Zera, G. H. Ballantyne, T. Le, J. P. Roberts, W. Conner, Richard H. Roettger, J. W. Sayre, J. D. Cheape, S. D. Fitzgerald, J. E. Martin, M. Anza, J. J. Tjandra, Herand Abcarian, J. J. Murray, Eli D. Ehrenpreis, E. Eisman, J. W. Fleshman, G. L. Daniel, A. C. Lowry, T. G. Lorentz, N. H. Hyman, F. Cavaliere, L. L. Jensen, Paul Sipe, D. A. Eastman, Y. Yamazaki, C. G. M. I. Baeten, Georgia Andrianopoulos, H. S. Goh, W. E. Mashas, J. K. Rowe, S. W. Larach, T. J. O'Kelly, R. M. Pitsch, M. Cosimelli, S. Jakate, E. Mitchell, L. K. Harding, J. Kraus, G. Friedberg, R. F. Hartmann, J. Jessurun, W. P. Mazier, M. J. Benson, R. L. Grotz, Adil H. Al-Humadi, J. P. Pena, I. J. Kodner, D. A. Rothenberger, J. M. Stone, K. W. Ecker, K. Ruoff, Richard E. Karulf, H. L. Young, S. P. Grobler, T. Saclarides, W. E. Lichliter, R. H. Grace, D. J. SchoetzJr., P. Lind, P. W. K. Lau, R. L. Cali, V. Fazio, H. Abdel-Nabi, T. Berk, V. D. Salanga, D. R. Antonenko, Steve Scoggin, John Dent, W. H. Boggs, R. Farouk, David E. Beck, John L. Skosey, M. R. Treat, R. S. McLeod, R. H. Lowndes, B. Bute, M. E. Pezim, V. W. Fazio, G. Di, W. DeVos, J. Tries, F. V. Lucas, Faith G. Davis, S. E. Oliver, P. Di Tora, D. Civalleri, G. Oliver, R. J. FitzgibbonsJr, K. B. Hosie, Steven D. Wexner, R. J. Davies, R. B. Hanson, E. D. Staren, Les Rosen, E. James, F. Ackroyd, C. Mitchell, M. P. Frick, Don Trepashko, E. Duberman, H. J. Järvinen, Richard C. Frazee, G. J. Blatchford, P. Bennett, J. H. Pemberton, T. R. Russell, Richard L. Nelson, E. Mannella, P. V. Vignati, K. Hojo, K. Kern, D. M. Meesig, C. H. Shatney, J. Heryer, M. Korst, J. C. Church, E. Ruggeri, W. G. Sheridan, David G. Jagelman, G. C. Ger, C. Falardeau, H. Stern, A. Ferrara, K. Sugihara, A. Shafik, P. B. Dobrin, J. C. Hebert, P. Luukkonen, M. Vierra, and E. H. VanBergen

Subjects
Convention, medicine.medical_specialty, business.industry, Surgical oncology, General surgery, Public health, Gastroenterology, medicine, General Medicine, business, Colorectal surgery
Published
1992
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4. Hepatitis B virus blood screening: Impact of nucleic amplification technology testing implementation on identifying hepatitis B surface antigen non-reactive window period and chronic infections

Author

Giancarlo Isacchi, A. Agresti, E. Girolami, P. Iudicone, E. Mannella, M. Palange, M. Miceli, Luca Pierelli, and A. Gallo

Subjects
Nucleic Acid Amplification Techniques, DNA, Viral, Blood Safety, Hepatitis B Surface Antigens, Blood Transfusion, Hepatitis B, Chronic, Hepatitis B Antibodies, Blood Donors, Humans, HBsAg, Blood transfusion, media_common.quotation_subject, medicine.medical_treatment, Window period, medicine.disease_cause, nat screening, blood safety, Medicine, Settore MED/05 - Patologia Clinica, Viral, blood donors, hbv infection, transfusion therapy, Chronic, media_common, Hepatitis B virus, business.industry, Transmission (medicine), Convalescence, Blood Screening, virus diseases, Hematology, General Medicine, DNA, Hepatitis B, medicine.disease, Virology, digestive system diseases, Immunology, business
Abstract

Despite improvements in hepatitis B surface antigen (HBsAg) test sensitivity, post-transfusion hepatitis B virus (HBV) infection still occurs because HBsAg is undetectable during the early window phase (WP) of the infection, in the convalescence core window phase of the infection, or in serologically silent chronic hepatitis or in mutant forms of HBV. HBV-DNA screening using high sensitivity nucleic amplification technology (NAT) assays has recently been introduced to reduce the residual risk of transmission of HBV by transfusion of blood components.Over 1 year 75 063 donations were individually screened for HBV-DNA by the Ultrio Procleix assay on the Tigris platform. The donations were collected in the Latium region, an area of the central Italy, and they accounted for the 40% of the total blood units collected in this area per year. The initial reactive samples were re-tested and confirmed by the discriminatory HBV assay. Additional HBV serological markers were also performed. Suspected WP infections were followed-up to monitor the development of the immune response. All HBV-DNA-positive donors were called back to check up their infectious status.The results of testing the 75 063 donations are: 33 donations HBsAg positive, 31 out of them HBV-DNA-positive and two HBV-DNA negative; 22 donations HBsAg-negative but HBV-DNA positive with low viral load. Six of the 22 were found to be consistently HBV-DNA reactive whereas the remaining 16 donations showed inconsistent results on multiple NAT retesting. One WP infection was confirmed by the follow-up of the donor for 3 months following the index blood donation.In the donor population of the Latium region, NAT screening has revealed a higher than expected number of donors who were HBsAg non-reactive but HBV-DNA-positive with three donors showing HBV-DNA as the only marker of infection. The adoption of genome screening has increased the safety of the blood supply and has also contributed to the protection of donor health by identifying either WP or clinically silent infections.

Published
2009

8. Unusual Phenotype (Leu 7+, OKT4+, OKMl+) Expressed by Cells from a Patient with an Abnormal Expansion of Granular Lymphocytes

Author

V. Zoli, G. Bonomo, E. Mannella, Isabella Quinti, Franco Pandolfi, A. De Laurenzi, G. De Sanctis, and L Pacilli

Subjects
Antibody-dependent cell-mediated cytotoxicity, education.field_of_study, Lymphocytosis, Chronic lymphocytic leukemia, Population, Lymphoproliferative disorders, hemic and immune systems, chemical and pharmacologic phenomena, Hematology, General Medicine, Biology, medicine.disease, Phenotype, In vitro, Immunology, medicine, Cytotoxic T cell, medicine.symptom, education
Abstract

We report the case of a 70-year-old female with a lymphocytosis which was casually detected during a routine examination. Immunological studies revealed the expansion of granular lymphocytes (GL) with the following, previously undescribed phenotype: Leu 7+, OKT3+ , OKT4+, OKT8-, OKM1+ . These cells were tested for their functional activities and found to exert neither helper nor suppressor functions in in vitro tests. Cytotoxic activities demonstrated a strong ADCC and a markedly reduced NK function. 1 year later the clinical course has remained good without any treatment and we suggest that this case should be classified as an abnormal expansion of GL, despite the OKT4 positivity of the cells. Our data point out the importance of a careful immunological study of cells from these rare patients and suggest the existence of a normal GL population expressing the OKT4 phenotype, which is possibly expanded in this patient.

Published
1984
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10. Platelet Antibodies in Different Forms of Chronic Thrombocytopenia

Author

Giuseppe Maria Gandolfo, Masala C, M.A. Amendolea, E. Mannella, and Antonella Afeltra

Subjects
Blood Platelets, Serotonin, Anti-nuclear antibody, Autoimmune thrombocytopenia, Autoimmune Diseases, Thromboplastin, Isoantibodies, immune system diseases, medicine, Humans, Lupus Erythematosus, Systemic, Platelet, skin and connective tissue diseases, Lupus erythematosus, biology, business.industry, Complement Fixation Tests, Hematology, General Medicine, medicine.disease, Thrombocytopenia, In vitro, Chronic Disease, Immunology, biology.protein, Antibody, business
Abstract

Three techniques have been employed for the in vitro detection of circulating platelet antibodies in thrombocytopenic patients affected by 'idiopathic' form or by lupus erythematosus (SLE), the complement fixation test, the platelet factor 3 availability test and the serotonin release test. 29 of the 35 sera tested (82.8%) gave positive results for antiplatelet activity. In particular the serotonin release test allows to distinguish 4 groups of patients: a first group affected by idiopathic form; two groups with autoimmune thrombocytopenia and various degrees of serotonin release, and finally a fourth group which comprises subjects affected by SLE, with circulating immunocomplexes.

Published
1977
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13. Book Reviews / Announcement

Author

V. Stocchi, G. Novelli, D.H. Pamphilon, Enzo Grosso, G. Bonomo, Mauro Girotto, D. Bareford, Gualtiero Büchi, Patrizia Ghelli, M. Resti, Nachum Freidin, C. Vullo, K.J.A. Miloszewski, Stelio Gario, A. Adeyokunnu, Alberto Bosi, L. Pacilli, E. Mannella, M.E. Rossi, Maurizio Borsotti, Paola Tozzi, J.D. Fear, M. Magnani, I. Zahavi, F. Streif, A. De Laurenzi, S. Machin, F. Bertrand, Cirino Zappalà, G. Alimena, Autino R, M.S. Losowsky, Bola O.A. Osifo, G. Thibaut, A. Víerucci, Isabella Quinti, Miles V. Joyner, V. Zoli, D.L. Barnard, B. Dallapiccola, Ehud Malberger, Lionello Camba, B. Legras, B. Presentey, Irene Ferrero, Termine G, P. Hewitt, F.A. Lukanmbi, P. Fishman, M. de Martino, J.P. Aymard, Benjamin Brenner, Giuliana De Sanctis, Giampiero Bellesi, S. Davies, P. Lederlin, M. Djaldetti, Pierluigi Rossi Ferrini, F. Pandolfi, Anna Carter, C. Janot, Ilana Tatarsky, and H. Cohen

Subjects
Hematology, General Medicine
Published
1984
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