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This study aims to see the extent to which the level of concentration ability of early childhood after games and brain exercises are carried out in a period of 3 months. Brain games and exercises with simple body movements accompanied by songs to make students more excited. Brain exercise has many benefits, especially to balance the left and right brain, through brain exercise activities can foster enthusiasm and children's learning. This study describes brain exercise activities carried out at the Al-Kautsar Quran Kindergarten in Bandung. The method used is a descriptive approach. Data collection techniques are observation, interviews and documentation, while the data analysis technique is data triangulation technique. The results of research at Al-Kautsar Quran Kindergarten show that brain exercise activities have been carried out well, seen from semester and daily planning and evaluations carried out for each brain exercise activity. The implementation of this brain exercise provides many benefits for children to be more focused, improve memory and be more enthusiastic

This study aimed to determine the effect of the principal's motivation on teacher performance at Integrated Islamic elementary school Matahati Bandung. The method used in this research is a quantitative approach with the associative method. The population in this study amounted to 30 teachers and was taken as a sample of 30 teachers with the research instrument in the form of a questionnaire. The result of this study; 1) the regression coefficient value is 1.006. So every one percent of motivation from the principal will improve teacher performance by 1,006. Thus the motivation of the principal has a positive effect on the teacher's performance. Square R-value = 0.610, hence the effect value is 61%. Thus, the provision of motivation from the principal can improve teacher performance by 60%; 2) the principal is significantly influential in efforts to improve teacher performance in SDIT Matahati with the magnitude of the influence by 90.6%; 3) Principals on teacher influence by 88.6%. The study results imply that the principal's motivation is a factor that can affect teacher performance.

The aims of this study were is to analyze the development of Islamic values for deaf students at The Little Hijabi Homeschooling; learn Islamic values applied to deaf students, especially in early childhood; examine the supporting and inhibiting factors in implementing the Islamic values and the way of The Little Hijabi Homeschooling in educating and developing Islamic values curriculum. The research method used was descriptive qualitative method and literature study. Data collection techniques in this study include is observation; interview; and documentation; searching for data through websites or journals. Qualitative data analysis used in this study with data reduction, data presentation, and drawing conclusions. It can be said that the development of Islamic values for deaf students, especially students at an early age, is very good and different from special schools used by people with disabilities in general which are only limited to PAI learning without any in-depth learning in applying the form of monotheism and Iqro learning with sign language

To create good learning achievement, it is necessary to pay attention to several factors, one of which is the method used. Mnemonic learning aims to make it easier for young children to master tajwid material. This study aims to determine the level of learning achievement of Early Childhood Education (PAUD) Mikhrajul Ulum Jambearum Sumberjambe Jember students. The research approach used is a qualitative type of case study. Data collection techniques used are observation, interviews and documentation. The data analysis was carried out circularly, starting from data collection, reduction, data display and conclusion. The study results showed that it became easier for students to master Tajweed material without feeling pressured and bored because, in practice, the teacher used songs, acronyms, and mind mapping in learning Tajweed material. Learning that takes place is very enjoyable. As for its application, the teacher's creativity is needed in developing methods (singing, acronyms, concept maps) that are appropriate to the learning material so that students can more easily master and remember the material and feel happy and not burdened in learning

Atrial fibrillation (AF) is one of the most common arrhythmias, associated with high morbidity, mortality, and healthcare costs, and it places a significant burden on both individuals and society. Anti-arrhythmic drugs are the most commonly used strategy for treating AF. However, drug therapy faces challenges because of its limited efficacy and potential side effects. Catheter ablation is widely used as an alternative treatment for AF. Nevertheless, because the mechanism of AF is not fully understood, the recurrence rate after ablation remains high. In addition, the outcomes of ablation can vary significantly between medical institutions and patients, especially for persistent AF. Therefore, the issue of which ablation strategy is optimal is still far from settled. Computational modeling has the advantages of repeatable operation, low cost, freedom from risk, and complete control, and is a useful tool for not only predicting the results of different ablation strategies on the same model but also finding optimal personalized ablation targets for clinical reference and even guidance. This review summarizes three-dimensional computational modeling simulations of catheter ablation for AF, from the early-stage attempts such as Maze III or circumferential pulmonary vein isolation to the latest advances based on personalized substrate-guided ablation. Finally, we summarize current developments and challenges and provide our perspectives and suggestions for future directions.

Madrasa are in a condition of interrelated problems, including inadequate funding, inadequate facilities, modest teachers and attending more than one school, low quality, lack of enthusiasm, low innovation, and low interest. Madrasas do not yet have an internal quality assurance. This research aims to reveal the implementation of quality management in Madrasah Aliyah Nurul Iman Cimahi City, Indonesia. The research method uses a qualitative descriptive approach that is describing phenomena in the implementation of quality in private madrasas. Data collection techniques used interview studies with the headmaster, deputy headmaster and educators; documentation study relating to documents related to 8 standards in madrasas; observational studies namely the implementation of quality, internal quality assurance in madrasas. The results showed that the low quality of education in the madrasas had an impact on funding madrasas that still did not have financial independence, madrassas still relied on madrasah operational assistance and monthly fees from students. The academic quality assurance agenda is carried out maximally by the madrasah academic community.

Introduction TET2, a member of the Ten-Eleven translocation gene family, catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine in DNA. Low expression of TET2 has been reported as a prognostic factor for several types of malignancies in adult patients. However, there have been few data on the effect of TET2 mRNA level on the prognosis of children with ALL so far. Methods In this study, TET2 expression of samples cryopreserved in the liquid nitrogen from January 1, 2007 through December 31, 2011 was retrospectively analyzed in 136 newly diagnosed ALL patients by real-time polymerase chain reaction (PCR) assay. The patients' samples were divided into two groups by the median value of patients group and divided into TET2 low and TET2 high groups. Results A total of 136 childhood ALL patients demonstrated lower TET2 expression than control group (P = .038). TET2 mRNA expression levels were correlated with the disease status. In addition, patients with low TET2 expression had lower platelet counts and lower CR rates. Survival analysis showed that low TET2 expression in children with ALL was associated with lower 5-year overall survival (OS) (63% vs 88%, P = .011) and event-free survival (EFS) (60% vs 85%, P = .003). Multivariate analysis revealed that low TET2 expression was an independent poor prognostic factor of OS and EFS. Conclusion Low expression of TET2 in children with ALL is associated with poor prognosis and can be used as a molecular prognostic marker for risk group stratification.

Background/Purpose Inflammation plays an important role in promoting ovarian tumorigenesis and cancer progression. However, the relationship between polymorphisms in inflammatory response genes and risk of ovarian cancer remains poorly understood. In this study, we investigated the association of PPARG Pro12Ala, IL6 -174G/C, E-selectin S128R, NFKB1 -94 ins/del, NFKBIA -826C/T, and ICAM-1 K469E polymorphisms with ovarian cancer risk in a Chinese population. Methods Genotyping of the polymorphisms was performed on 687 cases and 687 controls employing the PCR-RFLP technique, and the logistic regression model was used to measure the risk association. Results A significantly increased risk association was observed for the heterozygous genotypes of PPARG [odds ratio (OR) = 1.52, 95% confidence interval (CI) = 1.01–2.29] and E-selectin (OR = 1.77, 95% CI = 1.07–2.93) polymorphisms, as well as the homozygous ins/ins genotype of NFKB1 polymorphism (OR = 1.39, 95% CI = 1.00–1.92). By contrast, ICAM-1 KE genotype was associated with a decreased ovarian cancer risk (OR = 0.77, 95% CI = 0.60–0.98). In addition, the NFKB1 del/del + NFKBIA TT combination was also found to be associated with a decreased ovarian cancer risk, with OR = 0.12 (95% CI = 0.01–0.95). The associations of the NFKB1 and ICAM-1 polymorphisms replicated the findings of previous reports, assuring the reliability of the results obtained. Conclusion NFKB1 and ICAM-1 polymorphisms could serve as useful ovarian cancer risk prediction biomarkers for the Chinese population, while the utility of PPARG and E-selectin polymorphisms as biomarkers requires further confirmation in independent ovarian cancer cohorts.

Purpose Lung adenocarcinoma (LA) is one of the major types of lung cancer. MicroRNAs (miRNAs) play an essential role in regulating responses of natural killer (NK) cells to cancer malignancy. However, the mechanism of miR-218-5p involved in the killing effect of NK cells to LA cells remains poorly understood. Materials and methods The expression of miR-218-5p was examined by quantitative real-time polymerase chain reaction (qRT-PCR). Serine hydroxymethyl transferase 1 (SHMT1) level was detected by qRT-PCR or western blots. Cytokines production of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) were detected by ELISA. The killing effect of NK cells to LA cells was investigated using lactate dehydrogenase cytotoxicity assay kit. The interaction of miR-218-5p and SHMT1 was probed by luciferase activity assay. Xenograft model was established to investigate the killing effect of NK cells in vivo. Results miR-218-5p was enhanced and SHMT1 was inhibited in NK cells of LA patients, whereas stimulation of interleukin-2 (IL-2) reversed their abundances. Addition of miR-218-5p reduced IL-2-induced cytokines expression and cytotoxicity in NK-92 against LA cells. Moreover, SHMT1 was negatively regulated by miR-218-5p and attenuated miR-218-5p-mediated effect on cytotoxicity, IFN-γ and TNF-α secretion in IL-2-activated NK cells. In addition, miR-218-5p exhaustion inhibited tumor growth by promoting killing effect of NK cells. Conclusion miR-218-5p suppresses the killing effect of NK cells to LA cells by targeting SHMT1, providing a potential target for LA treatment by ameliorating NK cells function.

The paper discusses the basic principles of blind source separation and modal identification of structures, analyses the feasibility that using blind source separation techniques for modal parameter identification. According to the noisy features of the measured data in experiments, a second-order blind identification algorithm based on moving average method is proposed. By moving average method the noises are efficiently eliminated. It greatly improves the separation performance of this algorithm. The cantilever experiments verify the stability and the applicability of the algorithm.

The paper discusses the basic principle of blind source separation algorithm applying in structural modal identification. By improving the signal-whitening method, a robust second-order blind identification (RSOBI) algorithm is established on the basis of second-order statistics. The modal responses and mode shapes can be obtained using the RSOBI algorithm from the observed data of structures in time domain. Frequency and damping are estimated from the modal responses by traditional single degree of freedom methods. The simulation results show that the RSOBI algorithm has good performance in modal identification of structures.

Li4Ti5O12(PO4)x (x = 0.01-0.03) hollow microspheres are prepared via a template method and solid-state reaction.

Yuan yanghui tunnel as the engineering background of this study, the layout of USTB micro-seismic monitoring system is introduced. The positioning accuracy of the system has been adjusted according to artificial fixed blasting tests. Combining with the relationship between activity rate and time of micro-seismic events, different types of micro-seismic events have been distinguished, which explain the emergence of those events. The results show that the design and implementation of micro-seismic monitoring system can meet the global monitoring of rock mass deformation during the construction of the tunnel. Imported with location condition, combining micro-seismic monitoring with conventional monitoring technique can find the concentration zone of rock failure more exactly and orientate the position of potential instable face, which has considerable engineering guiding significance and economic benefit.

A new triterpenoid, 2beta,3beta,19alpha,24-tetrahydroxy-23-norurs-12-en-28-oic acid (4), together with three known triterpenoids 3-oxo-19alpha,23,24-trihydroxyurs-12-en-28-oic acid (1), 2alpha,3beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (2), 2alpha,3alpha,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (3), was isolated from the roots of Symplocos chinensis. The new triterpenoid shows significant cytotoxic activity against B16 and BGC-823 cells.