32 results on '"Andrzej Paradysz"'
Search Results
2. Not as black as it is painted? The impact of the first wave of COVID-19 pandemic on surgical treatment of urological cancer patients in Poland a cross-country experience
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Mieszko Kozikowski, Piotr Zapała, Bartosz Małkiewicz, Marcin Jarzemski, Łukasz Zapała, Andrzej Paradysz, Dominik Chorągwicki, Aleksander Ślusarczyk, Piotr Petrasz, Piotr Radziszewski, Remigiusz Stamirowski, Jakub Dobruch, Jacek Zostawa, Joanna Zajączkowska, Piotr Chlosta, Romuald Zdrojowy, Tomasz Drewa, Mikolaj Przydacz, Blazej Kuffel, Bartosz Dybowski, Magdalena Szymańska, Bartosz Brzoszczyk, Maciej Przudzik, Marek Roslan, Wojciech Krajewski, Piotr Jarzemski, Przemysław Kubik, Rafał Osiecki, Paweł Kiełb, and Pawel Rajwa
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medicine.medical_specialty ,Cross country ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Family medicine ,Pandemic ,medicine ,Urological cancer ,General Medicine ,medicine.disease_cause ,business ,Coronavirus - Abstract
IntroductionIn the majority of Western European countries, the coronavirus disease (COVID-19) pandemic has led to a dramatic reduction in urooncological surgeries. Our objective was to evaluate the impact of the pandemic on volume and patterns of urooncological surgery in Poland.Material and methodsThis is a retrospective analysis of 10 urologic centres in Poland. Data regarding major oncological procedures performed after the COVID-19 pandemic outbreak (March 15, 2020 – May 31, 2020) were evaluated and compared with data from the respective period in 2019.ResultsBetween March 15, 2020 and May 31, 2020, a total of 968 oncological procedures were performed in participating centres. When compared to the respective period in 2019 (1063 procedures) the overall number of surgeries declined by 8.9%. The reduction was observed for transurethral resection of bladder tumour (TURBT) (20.1%) and partial nephrectomies (PN) (16.5%). Surgical activity considering radical nephrectomy (RN), nephroureterectomy (NU), and radical prostatectomy (RP) remained relatively unchanged, whereas radical cystectomy (RC) burden showed a significant increase (90.9%). Characteristics of patients treated with TURBT, RC, NU, PN, and RN did not differ significantly between the compared periods, whereas RP in the COVID-19 period was performed more frequently in patients with a higher grade group (p = 0.028) and positive digital rectal examination (p = 0.007).ConclusionsSurgical activity for urological cancers in Poland has been maintained during the first wave of the COVID-19 pandemic. The Polish strategy in the initial period of the COVID-19 crisis mirrors the scenario of hard initial lockdown followed by adaptive lockdown, during which oncological care remained undisrupted and did not require particular priority triage.
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- 2023
3. Awareness of testicular cancer among adult Polish men and their tendency for prophylactic self-examination: conclusions from Movember 2020 event
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Jakub Ryszawy, Maksymilian Kowalik, Jakub Wojnarowicz, Grzegorz Rempega, Michał Kępiński, Bartłomiej Burzyński, Paweł Rajwa, Andrzej Paradysz, and Piotr Bryniarski
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Adult ,Male ,Health Knowledge, Attitudes, Practice ,Reproductive Medicine ,Testicular Neoplasms ,Urology ,Humans ,General Medicine ,Poland ,Neoplasms, Germ Cell and Embryonal - Abstract
Background Testicular cancer (TC), due to its non-specific symptoms and occurrence in young men, is particularly dangerous. A critical point for early diagnosis is awareness of the disease and the willingness to perform a testicular self-examination (TSE). The main aim of the study was to assess the knowledge of 771 adult men about testicular cancer. Additionally, the sources of information on TC and TSE were analyzed and the influence of demographic factors on the willingness to join preventative programs was examined. Materials and methods The study was carried out during the Movember2020 campaign, where a testicular ultrasound was performed on participants. They were asked to complete a questionnaire with 26 questions to assess their knowledge. Results The results obtained in the study indicate a low level of knowledge (average 3.5 points out of 18) about TC. Living in a large city (OR = 1.467; p = 0.03), as well as an earlier conversation about TC (OR = 1.639; p = 0.002), increased the awareness about the disease. Additionally it showed that many participants do not perform TSE at all (52.4%) and that only few perform TSE frequently (18.4%). Relationship status (OR = 2.832; p p = 0.02) was reported to be the main contributing factors in males deciding to have TSE. Conclusions Our research indicates large educational neglect in terms of knowledge about TC and reluctance in performing TSE. It is worth carrying out preventative actions periodically on an increasing scale, not only for the screening of testicular cancer, but also to expand knowledge on this subject.
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- 2021
4. Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma
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Pawel Rajwa, Andrzej Paradysz, Maciej Gaździk, Monika Slabon-Turska, Iga Florczyk, Bartłomiej Burzyński, and Marcin Życzkowski
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medicine.medical_specialty ,renal cell carcinoma ,Proportional hazards model ,business.industry ,neutrophil-to-mean platelet volume ratio ,medicine.medical_treatment ,Urology ,neutrophil ,General Medicine ,medicine.disease ,Nephrectomy ,03 medical and health sciences ,Clear cell renal cell carcinoma ,0302 clinical medicine ,Renal cell carcinoma ,Clinical Research ,platelets ,medicine ,Biomarker (medicine) ,Population study ,biomarker ,030212 general & internal medicine ,Mean platelet volume ,business ,Survival analysis - Abstract
Introduction The present study investigated the prognostic value of neutrophil-to-mean platelet volume ratio (NMPVR) for overall (OS) and cancer-specific survival (CSS) in patients treated with nephrectomy for localized clear cell renal cell carcinoma (ccRCC). Material and methods Medical records of 344 consecutive patients who underwent partial or radical nephrectomy for M0 ccRCC were retrospectively analyzed. Based on the median NMPVR, the study population was divided into two groups: the high NMPVR group with NMPVR higher than or equal to the median, and the low NMPVR group with NMPVR lower than the median. Comparisons of baseline characteristics and laboratory and pathological findings were performed. Kaplan-Meier survival curves and Cox regression model analysis were used to assess the prognostic value of the NMPVR. Results Patients with higher NMPVR values were more frequently diagnosed with advanced disease, tumor necrosis and higher tumor grade. The OS and CSS were significantly shorter in patients with NMPVR ≥ 0.41 compared to patients with NMPVR < 0.41. Inclusion of NMPVR in multivariable models of OS and CSS with other confounding variables determined categorized NMPVR as an independent prognostic factor for both endpoints. Conclusions Pretreatment NMPVR ≥ 0.41 was associated with lower OS and CSS. NMPVR might be applied as a cheap and uncomplicated prognostic indicator in localized ccRCC patients treated with a primary surgical approach.
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- 2019
5. Use of the International Index of Erectile Function to assess sexual dysfunction in the male population with prostate cancer treated by radical prostatectomy – a systematic review
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Andrzej Paradysz, Tomasz Jurys, Piotr Bryniarski, and Bartlomiej Burzynski
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medicine.medical_specialty ,Index (economics) ,Prostatectomy ,business.industry ,medicine.medical_treatment ,Urology ,General Medicine ,Erectile function ,medicine.disease ,Prostate cancer ,Erectile dysfunction ,Sexual dysfunction ,medicine ,Male population ,medicine.symptom ,business - Abstract
Introduction: Prostate carcinoma is the second most commonly diagnosed cancer among men, accounting for 14.1% of diagnoses and with a 6.8% mortality rate. Among current treatment options, radical prostatectomy is strongly indicated for localized prostate cancer. Although surgical techniques for radical prostatectomy are constantly being improved in terms of effectiveness and safety, postoperative disorders such as stress urinary incontinence and sexual dysfunction, including erectile dysfunction, remain quite common. Aim: The aim of our systematic review is to discuss the prevalence and severity of sexual dysfunction in the population of men suffering from prostate cancer who have been treated by means of radical prostatectomy. Material and methods: For the purposes of this systematic review we undertook a search of the literature in five databases using the English and Polish languages. We have focused on studies which assess sexual dysfunction using the International Index of Erectile Function (IIEF) questionnaire. Results and discussion: A total of 145 potentially relevant studies was retrieved. After selection, it was determined that 5 studies fulfilled the eligibility criteria and these were selected for qualitative synthesis. Our systematic review supports the finding that impairment of sexual function continues during the first 12 months after radical prostatectomy. Conclusions: Sexual dysfunction is a common complication after radical prostatectomy, and recovery takes at least 12 months. The male population with prostate cancer is at risk of sexual dysfunction even before radical prostatectomy due to age, comorbidities and mental factors related to the course of the disease.
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- 2021
6. Influence of SGLT2 Inhibitor Treatment on Urine Antioxidant Status in Type 2 Diabetic Patients: A Pilot Study
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Piotr Adamczyk, Tomasz Stompór, Mirela Hendel, Katarzyna Sedlaczek, Krzysztof Irlik, Hanna Kwiendacz, Diana Nabrdalik-Leśniak, Andrzej Paradysz, Tomasz Sawczyn, Patryk Główczyński, Karolina Drożdż, Katarzyna Nabrdalik, Paweł Stelmach, Janusz Gumprecht, Sławomir Kasperczyk, and Weronika Hajzler
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0301 basic medicine ,Aging ,Antioxidant ,Article Subject ,medicine.medical_treatment ,education ,Pilot Projects ,Urine ,030204 cardiovascular system & hematology ,Pharmacology ,medicine.disease_cause ,behavioral disciplines and activities ,Biochemistry ,Antioxidants ,Superoxide dismutase ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Sodium-Glucose Transporter 2 Inhibitors ,QH573-671 ,biology ,business.industry ,Healthy subjects ,Type 2 Diabetes Mellitus ,Cell Biology ,General Medicine ,Middle Aged ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Catalase ,biology.protein ,SGLT2 Inhibitor ,Cytology ,business ,psychological phenomena and processes ,Oxidative stress ,Research Article - Abstract
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been recognized as potent antioxidant agents. Since SGLT2i are nephroprotective drugs, we aimed to examine the urine antioxidant status in patients with type 2 diabetes mellitus (T2DM). One hundred and one subjects participated in this study, including 37 T2DM patients treated with SGLT2i, 31 T2DM patients not using SGLT2i, and 33 healthy individuals serving as a control group. Total antioxidant capacity (TAC), superoxide dismutase (SOD), manganese superoxide dismutase (MnSOD), free thiol groups (R-SH, sulfhydryl groups), and catalase (CAT) activity, as well as glucose concentration, were assessed in the urine of all participants. Urine SOD and MnSOD activity were significantly higher among T2DM patients treated with SGLT2i than T2DM patients without SGLT2i treatment ( p = 0.009 and p = 0.003 , respectively) and to the healthy controls ( p = 0.002 and p = 0.001 , respectively). TAC was significantly lower in patients with T2DM treated with SGLT2i when compared to those not treated and healthy subjects ( p = 0.036 and p = 0.019 , respectively). It could be hypothesized that the mechanism by which SGLT2i provides nephroprotective effects involves improvement of the SOD antioxidant activity. However, lower TAC might impose higher OS (oxidative stress), and elevation of SOD activity might be a compensatory mechanism.
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- 2021
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7. Restaging Transurethral Resection of Bladder Tumours after BCG Immunotherapy Induction in Patients with T1 Non-Muscle-Invasive Bladder Cancer Might not Be Associated with Oncologic Benefit
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Giuseppe Simone, Evanguelos Xylinas, Maria Cristina Marconi, Romuald Zdrojowy, Mario Alvarez-Maestro, Joanna Krajewska, Ettore Di Trapani, Karl H. Tully, Andrea Mari, Sławomir Poletajew, Alessandro Antonelli, Radosław Piszczek, Tim Muilwijk, Stefania Zamboni, Riccardo Mastroianni, Wojciech Krajewski, Andrzej Tukiendorf, Ekaterina Laukhtina, Anna Kołodziej, Andrea Rodriguez Serrano, Jeremy Yuen-Chun Teoh, Claudio Simeone, Alessandro Tafuri, Kees Hendricksen, Marco Moschini, Aleksandra Zdrojowy-Wełna, Łukasz Nowak, Andrzej Paradysz, Steven Joniau, Alessandra Gozzo, Luca Afferi, Guillaume Ploussard, and Pawel Rajwa
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medicine.medical_specialty ,CARCINOMA ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,lcsh:Medicine ,PROGRESSION ,1ST ,Tertiary care ,Article ,Resection ,03 medical and health sciences ,Medicine, General & Internal ,0302 clinical medicine ,General & Internal Medicine ,medicine ,In patient ,BCG ,RECURRENCE ,Science & Technology ,Bladder cancer ,business.industry ,lcsh:R ,Bcg immunotherapy ,General Medicine ,Immunotherapy ,medicine.disease ,bladder cancer ,reTURB ,Clinical Practice ,030220 oncology & carcinogenesis ,Non muscle invasive ,business ,Life Sciences & Biomedicine - Abstract
Background and Purpose: The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2&ndash, 6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Gué, rin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG approach. The aim of this study was to assess whether the performance of reTURB after BCG induction in T1HG bladder cancer is related to potential oncological benefits. Materials and Methods: Data from 645 patients with primary T1HG bladder cancer treated between 2001 and 2019 in 12 tertiary care centres were retrospectively reviewed. The study included patients who underwent reTURB before BCG induction (Pre-BCG group: 397 patients, 61.6%) and those who had reTURB performed after BCG induction (Post-BCG group: 248 patients, 38.4%). The decision to perform reTURB before or after BCG induction was according to the surgeon&rsquo, s discretion, as well as a consideration of local proceedings and protocols. Due to variation in patients&rsquo, characteristics, both propensity-score-matched analysis (PSM) and inverse-probability weighting (IPW) were implemented. Results: The five-year recurrence-free survival (RFS) was 64.7% and 69.1% for the Pre- and Post-BCG groups, respectively, and progression-free survival (PFS) was 82.7% and 83.3% for the Pre- and Post-BCG groups, respectively (both: p >, 0.05). Similarly, neither RFS nor PFS differed significantly for a five-year period or in the whole time of observation after the PSM and IPW matching methods were used. Conclusions: Our results suggest that there might be no difference in recurrence-free survival and progression-free survival rates, regardless of whether patients have reTURB performed before or after BCG induction.
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- 2020
8. How has the COVID-19 pandemic impacted Polish urologists? Results from a national survey
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Dominik Chorągwicki, Piotr Radziszewski, Piotr Chlosta, Pawel Rajwa, Rafał B. Drobot, Mikolaj Przydacz, Jakub Ryszawy, Piotr Zapała, Andrzej Paradysz, and Gniewko Więckiewicz
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medicine.medical_specialty ,Original Paper ,business.industry ,Incidence (epidemiology) ,Respiratory infection ,COVID-19 ,General Medicine ,Mental health ,Family life ,030227 psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Family medicine ,Health care ,Pandemic ,Medicine ,Outpatient clinic ,resident ,survey ,030212 general & internal medicine ,Poland ,business ,Adverse effect ,urology - Abstract
Sept 15, 2020 Introduction Poland was initially less affected by the coronavirus disease 2019 (COVID-19) pandemic, however, severe restrictions, and health care restructuration have impacted all areas of medicine, including urology [ ]we aimed, via an online survey, to examine the impact of the COVID-19 pandemic on Polish urologists and urology residents [ ]despite initial success with flattening the COVID-19 incidence curve, escalating restrictions, further health care restructuration (including the opening of COVID-19-dedicated hospitals), and unexplored COVID-19 fear likely led to indirect adverse effects of the pandemic also impacting Polish physicians and their work [ ]COVID-19, a droplets-transmitted respiratory infection, despite not being in the initial scope of treatment of urologists, has impacted all areas of urology including emergencies, outpatient clinics, elective surgeries, as well as physicians' everyday lives [6, 7] Most of the responders felt that their main worksite provided PPE (definitely yes: 20 09%;rather yes: 49 78%), with 78 60% believing that the availability of PPE has improved since the outbreak in March, 2020 [ ]86 92% of doctors reported over 25% declines in outpatient consultations and 55 90% claimed that their income dropped over 25% There were also other borderline significant results, such as more urologists and residents working in the COVID-19 centers indicating >50% earnings decreases as compared to those not in COVID-19 dedicated centers (36 1% vs 21 2%) DISCUSSION Our study indicates that the COVID-19 pandemic has deeply and negatively influenced Polish urologists and urology residents, in terms of clinical practice, financial situation, mental health, and family life
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- 2020
9. Basic Parameters of Blood Count, Serum Sodium, and Creatinine as Prognostic Factors for Renal Cell Carcinoma at Five-Year Follow-Up
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Marcin Życzkowski, Grzegorz Prokopowicz, Andrzej Paradysz, Paweł Stelmach, Pawel Rajwa, Piotr Taborowski, and Krzysztof Nowakowski
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Male ,medicine.medical_specialty ,Sodium ,030232 urology & nephrology ,chemistry.chemical_element ,Gastroenterology ,Metastasis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Clinical Research ,Risk Factors ,Renal cell carcinoma ,Internal medicine ,Carcinoma ,Humans ,Medicine ,Platelet ,Carcinoma, Renal Cell ,Creatinine ,Platelet Count ,business.industry ,General Medicine ,Middle Aged ,Nomogram ,Prognosis ,medicine.disease ,Kidney Neoplasms ,Blood Cell Count ,Logistic Models ,chemistry ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Female ,Neoplasm Recurrence, Local ,business ,Kidney cancer ,Follow-Up Studies - Abstract
BACKGROUND Several nomograms were developed for predicting the potential recurrence and cancer death risk in renal cell carcinoma patients. The combination of TNM classification and appropriately selected clinical classifiers allows for the creation of simple and effective risk calculators. MATERIAL AND METHODS There were 230 patients with renal cell cancer enrolled in this study. Basic parameters of blood count, serum creatinine and sodium concentrations, and histopathological features of the tumors were analyzed. A determination of whether any of the tested parameters could be used to assess the prognosis of kidney cancer was performed. RESULTS When the platelet cell count (PLT) increased by 10 thousand/µL, the risk of metastasis was higher by 5%, and cancer recurrence and death by 10%. A low-risk recurrence group was identified: T1b, PLT230, Na of 140.6 mmol/L. A high-risk recurrence group was identified: T3a, PLT280, Na of 143.4 mmol/L. A low-risk cancer specific mortality group was identified: T2a, absence of metastases, preoperative creatinine level of 85.6 µmol/L, and the value of PLT 227.0×103. A high-risk cancer specific mortality group was identified: T3a, the presence of metastases in the lungs (M), serum creatinine before treatment level of 97.9 µmol/L, and the value of PLT 299.5×10³. CONCLUSIONS Preoperative PLT, serum sodium, and tumor staging were independent risk factors for local recurrence. Blood PLT, serum sodium, creatinine, and tumor staging were useful indicators for estimating 5-year cancer specific survival.
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- 2018
10. Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy
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Andrzej Paradysz, Piotr Bryniarski, Marcin Życzkowski, Kamil Suliga, Kamil Bujak, Pawel Rajwa, and Monika Slabon-Turska
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medicine.medical_specialty ,renal cell carcinoma ,Multivariate analysis ,medicine.medical_treatment ,030232 urology & nephrology ,renal cell cancer ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Clinical Research ,Internal medicine ,Clinical endpoint ,medicine ,platelet-lymphocyte ratio ,In patient ,neutrophil-lymphocyte ratio ,Surgical approach ,medicine.diagnostic_test ,business.industry ,Complete blood count ,Patient survival ,General Medicine ,medicine.disease ,Nephrectomy ,derived neutrophil-lymphocyte ratio ,030220 oncology & carcinogenesis ,Immunology ,business ,lymphocyte-monocyte ratio - Abstract
Introduction The association between novel blood-based inflammatory indices and patient survival has been reported with reference to various cancers. The aim of this study was to investigate the prognostic value of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR) and lymphocyte-monocyte ratio (LMR) in patients with renal cell carcinoma (RCC) treated with nephrectomy. Material and methods From 2003 to 2012, 455 patients who underwent partial or radical nephrectomy for RCC were enrolled in the study. The study endpoints were overall survival (OS) and cancer-specific survival (CSS). Results The median follow-up was 70 months. Groups of patients with high levels of PLR, NLR and dNLR and a low level of LMR more often underwent radical nephrectomy, had a higher cancer stage in the TNM classification, and were more frequently diagnosed with tumor necrosis in histopathological examination. Both cancer-specific mortality and overall mortality were significantly higher in patients with high PLR, NLR and dNLR and low LMR. Multivariate analysis of CSS, adjusted for standard clinicopathological factors, identified only dNLR (p = 0.006) as an independent prognostic factor. PLR (p = 0.0002), dNLR (p = 0.0003) and NLR (p = 0.002), but not LMR (p = 0.1), achieved prognostic significance in multivariable analysis regarding OS. Conclusions Only dNLR was an independent prognostic factor for CSS and OS. Nevertheless, our study indicates that all examined complete blood count-based biomarkers may be useful tools in managing RCC patients treated with a surgical approach.
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- 2017
11. Application of Pneumatic Lithotripter and Holmium Laser in the Treatment of Ureteral Stones and Kidney Stones in Children
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Pawel Rajwa, Bartosz Muskała, Piotr Bryniarski, Rafał Bogacki, Marcin Życzkowski, Andrzej Paradysz, and Krzysztof Nowakowski
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Male ,Comparative Effectiveness Research ,medicine.medical_specialty ,Article Subject ,Adolescent ,Operative Time ,030232 urology & nephrology ,Holmium laser ,Solid-state ,lcsh:Medicine ,Lasers, Solid-State ,Holmium Lasers ,General Biochemistry, Genetics and Molecular Biology ,Kidney Calculi ,03 medical and health sciences ,0302 clinical medicine ,Lithotripsy ,Ureteroscopy ,Humans ,Medicine ,Child ,Urinary Tract ,Retrospective Studies ,General Immunology and Microbiology ,business.industry ,lcsh:R ,Follow up studies ,Treatment options ,General Medicine ,medicine.disease ,Surgery ,Treatment Outcome ,Child, Preschool ,030220 oncology & carcinogenesis ,Child population ,Operative time ,Female ,Laparoscopy ,Kidney stones ,business ,Follow-Up Studies ,Research Article - Abstract
Objective.Treatment options for urolithiasis in children include URSL and RIRS. Various types of energy are used in the disintegration of deposits in these procedures. We decided to evaluate the usefulness of URSL and RIRS techniques and compare the effectiveness of pneumatic lithotripters and holmium lasers in the child population based on our experience.Materials and Methods.One hundred eight (108) children who underwent URSL and RIRS procedures were enrolled in the study and divided into two (2) groups according to the type of energy used: pneumatic lithotripter versus holmium laser. We evaluated the procedures’ duration and effectiveness according to the stone-free rate (SFR) directly after the procedure and after fourteen (14) days and the rate of complications.Results.The mean operative time was shorter in the holmium laser group. A higher SFR was observed in the holmium laser but it was not statistically significant in the URSL and RIRS procedures. The rate of complications was similar in both groups.Conclusions.The URSL and RIRS procedures are highly efficient and safe methods. The use of a holmium laser reduces the duration of the procedure and increases its effectiveness in comparison with the use of a pneumatic lithotripter.
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- 2017
12. Percutaneous Nephrolithotomy with Amplatz and Alken Dilators: An Eight-Year Single Tertiary Care Centre Experience
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Andrzej Paradysz, Paweł Stelmach, Mateusz Adamkiewicz, Piotr Bryniarski, Marcin Życzkowski, Pawel Rajwa, and Piotr Taborowski
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Adult ,Male ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Group ii ,030232 urology & nephrology ,Urology ,Tertiary care ,Tertiary Care Centers ,03 medical and health sciences ,Kidney Calculi ,0302 clinical medicine ,Postoperative Complications ,Urolithiasis ,Clinical Research ,medicine ,Humans ,Percutaneous nephrolithotomy ,Grade IIIa ,Nephrostomy, Percutaneous ,Retrospective Studies ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,Dilatation ,Surgery ,030220 oncology & carcinogenesis ,Dilator ,Nephrostomy ,Female ,business - Abstract
BACKGROUND Percutaneous nephrolithotomy (PNL) is the standard procedure for patients with renal stones over 2 cm in diameter. We analyzed complications after this procedure focusing on two different methods of tract dilation. MATERIAL AND METHODS Between August 2008 and April 2016 222 percutaneous nephrolithotomies were performed in a total of 208 patients. The Group I (n=123) comprised patients where Alken dilatators were used, while Group II (n=99) comprised patients where Amplatz dilators were used. Efficacy was examined based on ultrasound and x-ray examination one month after the procedure. Complications were recorded using Clavien Dindo classification. RESULTS Efficacy was 85.3% and 86.8% in group I and II, respectively (p=0.77). Grade I complications were present in 14.6% and 3%, grade II were present in 9.7% and 8%, grade IIIa were present in 2.4% and 2%, grade IIIb were present in 1.6% and 2%, grade IVa were present in 1.6% and 7%, grade IVb were present in 3.2% and 1% in Group I and Group II, respectively. These differences were statistically significant (p=0.03). CONCLUSIONS Efficacy was comparable between Alken dilator and Amplatz dilator groups. In group I, there were more postoperative fevers >38.5 °C and a higher rate of urosepsis. On the other hand, in group II we observed more pleural injuries. All differences resulted from the type of access to the kidney (inter/infracostal), punctured calyx, and utilization (or not) of access sheath rather than type of dilators itself.
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- 2016
13. Physiotherapeutic assessment and management of chronic pelvic pain syndrome
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Andrzej Paradysz, Bartłomiej Burzyński, Tomasz Jurys, Katarzyna Cempa, and Kamil Burzynski
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Male ,medicine.medical_specialty ,Rectum ,Pelvic Pain ,chronic pelvic pain syndrome ,03 medical and health sciences ,0302 clinical medicine ,Scrotum ,medicine ,Humans ,case report ,physiotherapy techniques ,Clinical Case Report ,030212 general & internal medicine ,Physical Therapy Modalities ,Pelvic floor ,business.industry ,Pelvic pain ,Pelvic Floor ,Syndrome ,General Medicine ,Middle Aged ,Musculoskeletal Manipulations ,Perineum ,medicine.anatomical_structure ,Urethra ,030220 oncology & carcinogenesis ,Physical therapy ,Abdomen ,Chronic Pain ,medicine.symptom ,Manual therapy ,business ,Research Article - Abstract
Introduction: Chronic pelvic pain syndrome is difficult for the diagnosis and therapy and that means the patient attending the physician or physiotherapist may present various symptoms. There are no guidelines concern physiotherapy diagnosis and treatment of chronic pelvic pain syndrome. This study presents the physiotherapeutic assessment and management in men with pelvic pain symptoms. Patient concerns: Forty-six-year-old man attended the physiotherapy consulting room due to symptoms of pain in the perineum, lower abdomen, urethra, and scrotum for a year. Earlier, the patient had consulted a urologist who made a diagnosis of cystitis and prescribed medications that did not get results. Diagnosis: Ultrasound imaging and manual inspection (per rectum) of the pelvic floor was conducted by physiotherapist. Also, the abdominal and lower extremities muscles were assessed. Patient reported pain symptoms during examination of the musculus ischiocavernosus, puboanalis, pubococcygeus, iliococcygeus, coccygeus, and canalis pudentalis seu Alcocki. Interventions: The patient was given physiotherapeutic interventions consisting in the manual therapy of the lumbopelvic hip complex and the manual therapy per rectum. Outcomes: During 10th session of the physiotherapeutic treatment, patient reported improvement in pain symptoms. A month later, patient reported total alleviation of the pain symptoms during control visit. Conclusion: Therapy of chronic pelvic pain syndrome is a process that involves application of different therapies and different approaches. Functional and structural assessment and also therapy conducted by physiotherapist is becoming an integral part of urology and represents 1 possible conservative treatment form.
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- 2021
14. Sacrocolpopexy with Polypropylene Tape as Valuable Surgical Modification during Cystectomy with Orthotopic Ileal Bladder: Functional Results
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Andrzej Paradysz, Zbigniew Kaletka, Krzysztof Nowakowski, Piotr Bryniarski, Marcin Życzkowski, Bartosz Muskała, and Rafał Bogacki
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Male ,medicine.medical_specialty ,Article Subject ,medicine.medical_treatment ,Urinary Bladder ,Urology ,lcsh:Medicine ,Urinary incontinence ,Urinary Diversion ,Cystectomy ,Polypropylenes ,General Biochemistry, Genetics and Molecular Biology ,Surgical methods ,law.invention ,Ileal bladder ,Quality of life ,Randomized controlled trial ,Ileum ,law ,Surveys and Questionnaires ,medicine ,Humans ,Orthopedic Procedures ,General Immunology and Microbiology ,Urinary retention ,business.industry ,lcsh:R ,Urinary diversion ,General Medicine ,Middle Aged ,Urodynamics ,Urinary Bladder Neoplasms ,Case-Control Studies ,Quality of Life ,Clinical Study ,Female ,medicine.symptom ,business - Abstract
Introduction. Urinary diversion is very often associated with urinary retention and urinary incontinence. In this study, a surgical modification during cystectomy with orthotopic ileal neobladder is presented.Material and Methods. Female patients enrolled in the study (n-24) were subjected to sacrocolpopexy during the operation. Apart from oncological control, the follow-up consisted of 1-hour inlay test and questionnaires (UDI-6 and IIQ-7) in the 3rd, 6th, and 12th month after the operation. In the 12th month after the surgery, the urodynamic pressure-flow test was performed. Outcomes were compared with the control group (n-18) in which sacrocolpopexy was not implemented.Results. The study group was characterised by reduced urinary retention and improved continence.Conclusion. Sacrocolpopexy during cystectomy with orthotopic ileal bladder is a valuable surgical method which provides patients with a better quality of life.
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- 2015
15. Cochlear Function Monitoring after Spinal Anesthesia
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Agata Janecka-Placek, Andrzej Paradysz, Hanna Misiołek, and Grażyna Lisowska
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,medicine.medical_treatment ,Otoacoustic Emissions, Spontaneous ,Hemodynamics ,Lithotripsy ,Audiology ,Anesthesia, Spinal ,Cochlear function ,Fentanyl ,Young Adult ,Clinical Research ,otorhinolaryngologic diseases ,Humans ,Medicine ,Postoperative Period ,Cochlea ,Bupivacaine ,medicine.diagnostic_test ,business.industry ,Hearing Tests ,Spinal anesthesia ,Auditory Threshold ,General Medicine ,Middle Aged ,Hair Cells, Auditory, Outer ,Acoustic Stimulation ,Anesthesia ,Urologic Surgical Procedures ,Audiometry, Pure-Tone ,Female ,sense organs ,Audiometry ,business ,medicine.drug - Abstract
BACKGROUND The aim of the study was to examine the effect of spinal anesthesia on the function of cochlear outer hair cells (OHCs), determined by means of objective distortion product otoacoustic emissions (DPOAE) testing. To the best of our knowledge, our study was the second OAE-based analysis of cochlear function during spinal anesthesia, and the only experiment including such a large group of patients. MATERIAL AND METHODS The study included 20 patients (18 men and 2 women) subjected to a scheduled uretherorenoscopic lithotripsy with routine spinal anesthesia with 10 mg (2 ml) of 0.5% hyperbaric bupivacaine and 50 μg (1 ml) of fentanyl. The levels of DPOAEs and background noise at 1000-6000 Hz were recorded prior to and immediately after the anesthesia, and on the postoperative day 2. RESULTS We did not find significant differences between DPOAEs values recorded prior to and immediately after the anesthesia. The only exception pertained to 5652 Hz, at which a significantly higher level of DPOAEs was observed immediately after the anesthesia. The levels of DPOAEs at 2002 Hz and 2380 Hz collected on the postoperative day 2 were significantly higher than the respective baseline values. Irrespective of the frequency and time of testing, we did not find any significant differences between the recorded levels of background noise. CONCLUSIONS Our findings point to the lack of a detrimental effect of spinal anesthesia on objectively evaluated cochlear function, and thus suggest that this method is safe, even for OHCs, which are extremely susceptible to exogenous and endogenous injuries.
- Published
- 2015
16. Impact of Testosterone Replacement Therapy in Patients with Hypogonadism and High-Grade Prostate Intraepithelial Neoplasia or Atypical Small Acinar Proliferation in Prostate Biopsy
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Piotr Bryniarski, Rafał Bogacki, Zbigniew Kaletka, Andrzej Paradysz, Krzysztof Nowakowski, Mieczysław Fryczkowski, and Marcin Życzkowski
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PCA3 ,Intraepithelial neoplasia ,medicine.medical_specialty ,Atypical small acinar proliferation ,Prostate biopsy ,medicine.diagnostic_test ,business.industry ,Biomedical Engineering ,Urology ,Bioengineering ,Testosterone (patch) ,General Medicine ,medicine.anatomical_structure ,Prostate ,medicine ,In patient ,Testosterone replacement ,business ,General Psychology - Published
- 2015
17. Gangrene of the penis, scrotum, and perineum, occurred after radiotherapy of rectal cancer
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Bartosz Muskała, Marcin Zyczkowski, Rafał Bogacki, Andrzej Paradysz, Krzysztof Nowakowski, and Piotr Bryniarski
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Gangrene ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,medicine.medical_treatment ,surgical treatment ,Case Report ,General Medicine ,medicine.disease ,Surgery ,Perineum ,Radiation therapy ,General state ,radiation ,medicine.anatomical_structure ,Scrotum ,medicine ,multidisciplinary approach ,gangrene ,business ,Surgical treatment ,rectal cancer ,Penis - Abstract
We present a case of a 58-year-old man hospitalized because of gangrene of the penis and scrotum, after radiochemotherapy for rectal cancer. At the time of the admission the patient presented with extensive gangrene with necrosis affecting the scrotum and the penis. During the first day of hospitalization the patient was operated. Due to the progress of the disease he had to be operated again. The status of the patient, which initially was very bad, was gradually improving. He was discharged from the hospital after 59 days in a good general state with good wound healing.
- Published
- 2013
18. Ten-year treatment outcomes including blood cell count disturbances in patients with simple renal cysts
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Andrzej Paradysz, Zbigniew Kaletka, Piotr Bryniarski, Bartosz Muskała, Marcin Życzkowski, and Grzegorz Prokopowicz
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Blood Platelets ,Male ,Pathology ,medicine.medical_specialty ,Time Factors ,complications ,Renal function ,Hematocrit ,Preoperative care ,Body Mass Index ,Hemoglobins ,chemistry.chemical_compound ,Clinical Research ,Preoperative Care ,Polycystic kidney disease ,Humans ,Medicine ,Cyst ,simple renal cyst ,Aged ,Postoperative Care ,Creatinine ,medicine.diagnostic_test ,business.industry ,blood pressure ,General Medicine ,Kidney Diseases, Cystic ,medicine.disease ,Blood Cell Count ,Surgery ,Treatment Outcome ,Blood pressure ,chemistry ,Case-Control Studies ,Female ,business ,red blood cells ,Glomerular Filtration Rate ,Kidney disease - Abstract
BACKGROUND The simple renal cyst is the most common benign kidney disease. It may cause pain and hypertension, especially if significantly enlarged. As in polycystic kidney disease, blood cell count disturbances are frequently observed in simple renal cysts. The aim of our study was to assess such disturbances, changes in blood pressure, and complication rate in our patients undergoing surgery due to simple renal cyst in the last 10 years. MATERIAL AND METHODS 210 patients with simple renal cysts were underwent surgery between 2002 and 2012. Two different kinds of operation were conducted: aspiration of cyst fluid with injection of sclerosing agent, and laparoscopic/retroperitoneoscopic decortications of the cyst wall. A control group comprised 134 patients with benign prostate hyperplasia. The following data were obtained: cyst burden, hematocrit, hemoglobin, red blood cells, thrombocytes, occurrence of pain, and blood pressure before and after the operation. Complications were collected and presented in Clavien score. RESULTS Hematocrit, hemoglobin, and red blood cells were significantly increased in the experimental group. A positive correlation was observed between cyst burden and the parameters mentioned above. Of 91 patients with hypertension, 56 (61.7%) had blood pressure reduction after the operation. Treatment relieved the loin pain in 132 (88%) patients. Complications occurred in 15 (7.4%) patients. CONCLUSIONS Patients with simple renal cysts have high values of red blood cells, hematocrit, and hemoglobin. Treatment decreases blood pressure in patients with hypertension. Complications after treatment are rare and mild.
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- 2013
19. Basic Parameters of Blood Count as Prognostic Factors for Renal Cell Carcinoma
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Piotr Bryniarski, Grzegorz Prokopowicz, Andrzej Paradysz, Marcin Życzkowski, Rafał Bogacki, and Krzysztof Nowakowski
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Male ,medicine.medical_specialty ,Article Subject ,030232 urology & nephrology ,lcsh:Medicine ,Gastroenterology ,Preoperative care ,Disease-Free Survival ,General Biochemistry, Genetics and Molecular Biology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,Preoperative Care ,medicine ,Carcinoma ,Humans ,Mean platelet volume ,Carcinoma, Renal Cell ,Survival rate ,Aged ,Retrospective Studies ,General Immunology and Microbiology ,Platelet Count ,business.industry ,lcsh:R ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Surgery ,Survival Rate ,030220 oncology & carcinogenesis ,T-stage ,Female ,business ,Kidney cancer ,Research Article ,Follow-Up Studies - Abstract
Background. Renal cell carcinoma is the most common type of kidney cancer. Taking account of morbidity and mortality increase, it is evident that searching for independent prognostic factors is needed.Aim of the Study. The aim of the study was to analyze routinely performed blood parameters as potential prognostic factors for kidney cancer.Material and Methods. We have retrospectively reviewed the records of 230 patients treated for renal cell carcinoma in the years 2000–2006. Preoperative blood parameters, postoperative histopathological results, and staging and grading were performed. To estimate the risk of tumor recurrence and cancer specific mortality (CSM) within five years of follow-up, uni- and multivariate Cox and regression analyses were used. To assess the quality of classifiers and to search for the optimal cut-off point, the ROC curve was used.Results. T stage of the tumor metastasis is the most important risk factor for early recurrence and cancer specific mortality (p<0.001). The preoperative platelet count (PLT) above 351 × 103/uL (95.3%; 55.1%) and AUC of 77% are negative prognostic factors and correlate with increased cancer specific mortality (CSM) during the five-year follow-up (p<0.001). Increased risk of local recurrence was observed for PLT above 243.5 × 103/ul (59%; 88%) and AUC of 80% (p=0.001). The opposite was observed in the mean platelets volume (MPV) for cancer specific mortality (CSM). The cut-off point for the MPV was 10.1 fl (75.4%; 55.1%) and for the AUC is of 68.1% (p=0.047).Conclusions. Many analyzed parameters in univariate regressions reached statistical significance and could be considered as potential prognostic factors for ccRCC. In multivariate analysis, only T stage, platelet count (PLT), and mean platelet volume (MPV) correlated with CSM or recurrent ccRCC.
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- 2016
20. PSA mass as a marker of prostate cancer progression after radical prostatectomy
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Andrzej Paradysz, Piotr Bryniarski, and Mieczysław Fryczkowski
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Biochemical recurrence ,Male ,medicine.medical_specialty ,obesity ,medicine.medical_treatment ,Urology ,Kaplan-Meier Estimate ,urologic and male genital diseases ,Body Mass Index ,Prostate cancer ,Clinical Research ,Predictive Value of Tests ,Recurrence ,Biomarkers, Tumor ,Odds Ratio ,Medicine ,Humans ,Aged ,Prostatectomy ,Receiver operating characteristic ,business.industry ,Prostatic Neoplasms ,General Medicine ,PSA mass ,Middle Aged ,Prostate-Specific Antigen ,medicine.disease ,prostate cancer ,radical prostatectomy ,Log-rank test ,Molecular Weight ,Prostate-specific antigen ,Logistic Models ,ROC Curve ,Predictive value of tests ,hemodilution ,Disease Progression ,business ,Body mass index - Abstract
Summary Background Obese patients with prostate cancer may have lower preoperative PSA concentration due to hemodilution. Lower PSA concentration may falsely affect assessing the risk of progression after radical prostatectomy (RP). The aim of this study was to determine preoperative PSA mass as the absolute amount of PSA protein secreted into circulation, and evaluation of its usefulness in prediction of biochemical recurrence after RP. Material/Methods 177 patients after RP due to prostate cancer were included in the study. On the basis of formulas, PSA mass was calculated {PSA mass [μg] = (weight [kg])0.425 × (height [cm])0.72 × 0.007184 × 1.670 × PSA concentration [ng/ml]}. Patients were divided into 3 groups according to increasing values of PSA mass. The following features were assessed and compared between these groups (χ-square test): pathologic stage T3, nodal metastases, positive surgical margins, biochemical and local recurrence and the rate of death. Cancer-specific survival was assessed depending on PSA mass (Kaplan-Meier curves with log rank test). The usefulness of PSA mass in prediction of biochemical recurrence was compared with PSA concentration (logistic regression with ROC curves). Results Pathologic stage T3, nodal metastases, positive surgical margins and progression were more common in patients with higher levels of PSA mass (p
- Published
- 2011
21. The impact of adjuvant therapy in patients with biochemical recurrence on prostate cancer progression and mortality five years after radical prostatectomy
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Mieczysław Fryczkowski, Marian Suchodolski, Maciej Szczębara, Andrzej Paradysz, and Piotr Bryniarski
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Oncology ,Biochemical recurrence ,medicine.medical_specialty ,prostate ,Urological Oncology ,Prostatectomy ,business.industry ,Urology ,medicine.medical_treatment ,Cancer ,General Medicine ,prostate cancer ,medicine.disease ,Surgery ,Radiation therapy ,Prostate cancer ,Internal medicine ,medicine ,Adjuvant therapy ,cancer ,Clinical significance ,Adverse effect ,business ,hereditary prostate - Abstract
Introduction. The clinical significance of biochemical recurrence (BCR) after radical prostatectomy (RP) due to prostate cancer (PCa) is not unambiguous, sometimes being independent from the real progression. BCR is followed by a greater risk of adverse events and almost always results with the necessity for implementation of adjuvant therapy (AT). The aim of the following study was to examine the impact of AT in patients with BCR together with PCa progression and mortality 5-years after RP. Material and methods. Two hundred forty-seven patients after RP, who were treated in the period from 1995 to 2009, underwent the retrospective analysis. They were divided into three groups according to the applied AT after prior BCR diagnosis. The first group (n - 39) included patients treated with radiotherapy, along with hormonotherapy. The second group (n - 63) covers patients receiving hormonotherapy only. The third group (n - 145) consists of patients without BCR. Five-year general and disease-specific survival was evaluated and choice prognostic factors were compared. results. Five-year overall survival was 74.2% in group I, 88.3% in group II, and 98.7% in group III. Diseasespecific survival was: 76.9%, 90.5%, and 100% (p = 0.001), respectively. BCR was diagnosed in 102 (41.5%) patients; while in another 24 (23.5%) of them progression was diagnosed after the AT was applied. Conclusions. The risk of BCR 5-years after RP is greater in patients with high initial concentration of PSA, higher Gleason score, and clinical advancement. Five-year overall and disease-specific survivals are higher among patients after hormonotherapy alone compared to those after both radio- and hormonotherapy.
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- 2011
22. Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia
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Łukasz Sędek, Zenon P. Czuba, Andrzej Paradysz, Wojciech Król, and Ewelina Szliszka
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Male ,Psoralea corylifolia ,Apoptosis ,Biology ,Pharmacology ,Psoralea ,TNF-Related Apoptosis-Inducing Ligand ,Psoralidin ,chemistry.chemical_compound ,Coumarins ,Cell Line, Tumor ,LNCaP ,Humans ,Cytotoxic T cell ,Cytotoxicity ,Benzofurans ,Prostatic Neoplasms ,General Medicine ,Flow Cytometry ,biology.organism_classification ,Isoflavones ,Microscopy, Fluorescence ,chemistry ,Cancer cell ,Tumor necrosis factor alpha - Abstract
Numerous compounds detected in medical plants and dietary components or supplements possess chemopreventive, antitumor and immunomodulatory properties. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an important endogenous anticancer factor that induces apoptosis selectively in cancer cells. However, some tumor cells are resistant to TRAIL-mediated apoptosis. Naturally occurring agents could sensitize TRAIL-resistant cancer cells and augment their apoptotic activity. We examined the cytotoxic and apoptotic effects of neobavaisoflavone and psoralidin in combination with TRAIL on LNCaP prostate cancer cells. The cytotoxicity was evaluated by MTT and LDH assays. The apoptosis was detected using Annexin V-FITC by flow cytometry and fluorescence microscopy. The LNCaP cells were shown to be resistant to TRAIL-induced apoptosis. Our study demonstrated that neobavaisoflavone and psoralidin sensitized TRAIL-resistant cells and markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells. Cotreatment of LNCaP cells with 100 ng/ml TRAIL and 50 µM neobavaisoflavone or 50 µM psoralidin increased the percentage of the apoptotic cells to 77.5 ± 0.5% or 64.4 ± 0.5%, respectively. The data indicate the potential role of the bioactive compounds isolated from the medicinal plant Psoralea corylifolia (neobavaisoflavone and psoralidin) in prostate cancer chemoprevention through enhancement of TRAIL-mediated apoptosis.
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- 2011
23. A comparison of tumor progression in patients with simultaneous prostate cancer and prostate premalignant condition to patients with prostate cancer alone
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Maciej Szczębara, Mieczysław Fryczkowski, Aleksandra Sitko-Saucha, Andrzej Paradysz, and Andrzej Kupilas
- Subjects
PCA3 ,Oncology ,medicine.medical_specialty ,business.industry ,Cancer ,General Medicine ,medicine.disease ,Prostate cancer ,medicine.anatomical_structure ,Tumor progression ,Prostate ,Internal medicine ,medicine ,In patient ,business - Published
- 2010
24. PEDIATR IC UROLOGY Influence of nephrectomy on solitary kidney function in children with non-malignant diseases
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Andrzej Paradysz, Lidia Hyla-Klekot, and Piotr Bryniarski
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medicine.medical_specialty ,business.industry ,Urology ,Solitary kidney ,medicine.medical_treatment ,medicine ,Non malignant ,General Medicine ,business ,Nephrectomy - Published
- 2009
25. Evaluation of the influence of body mass index (BMI) and preoperative prostate specific antigen (PSA ) concentration on carcinoma of prostate progression, continence, and erection disorders in men after radical retropubic prostatectomy
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Piotr Bryniarski, Mieczysław Fryczkowski, Maciej Szczębara, and Andrzej Paradysz
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Urology ,medicine.medical_treatment ,General Medicine ,medicine.disease ,Metastasis ,Disease course ,Prostate-specific antigen ,medicine.anatomical_structure ,Prostate ,Internal medicine ,medicine ,Carcinoma ,business ,Body mass index ,Testosterone ,Radical retropubic prostatectomy - Published
- 2009
26. Influence of Orthodontic Rapid Maxillary Expansion on Nocturnal Enuresis in Children
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Andrzej Paradysz, Marcin Życzkowski, Lidia Postek-Stefańska, Marek Truszel, and Lidia Hyla-Klekot
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Male ,Palatal Expansion Technique ,Article Subject ,Adolescent ,Dentistry ,lcsh:Medicine ,Nocturnal ,General Biochemistry, Genetics and Molecular Biology ,Orthodontic Appliances ,Enuresis ,medicine ,Maxilla ,Humans ,Rapid maxillary expansion ,Child ,Alternative methods ,Treated group ,General Immunology and Microbiology ,business.industry ,lcsh:R ,General Medicine ,Etiology ,Female ,medicine.symptom ,business ,Research Article ,Nocturnal Enuresis - Abstract
Background. The etiology of nocturnal enuresis (NE) is multifactorial and has not been fully explained yet. New ways of treatment are constantly being investigated, including the rapid maxillary expansion (RME).Methods. A total of 41 patients diagnosed with NE were divided into two experimental groups: A and B. Group A included 16 children who have been treated with RME. Group B comprised 25 children who have not undertaken orthodontic treatment. Children from both groups have been monitored in monthly intervals, during a 12-month period, towards the intensification of NE. The comparative analysis of both groups has been conducted after 3 years of observation.Results. Statistical analysis has shown a 4.5 times increase of the probability of reduction of NE in the case of the treated group in comparison with the group of children who have not undergone orthodontic treatment. Unfortunately, the chance of obtaining total dryness diminished proportionally to the higher degree of intensification of enuresis at the beginning of the test.Conclusion. RME can constitute an alternative method of NE treatment in children, irrespective of the occurrence of upper jaw narrowing.
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- 2015
27. NSS for an RCC in a patient with renal insufficiency after heart transplant because of right ventricular tumor
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Grzegorz Prokopowicz, Marcin Zyczkowski, Piotr Bryniarski, Andrzej Paradysz, and Krzysztof Nowakowski
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NSS ,education.field_of_study ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Population ,Ischemia ,Case Report ,General Medicine ,medicine.disease ,RCC ,Surgery ,Immune system ,Renal cell carcinoma ,medicine ,Neoplasm ,Lymph ,education ,business ,heart transplant ,immunodeficiency ,Immunodeficiency - Abstract
The effect of the immunosuppressive therapy on the development of neoplasms has become the object of an ever increasing interest for clinicians all over the world. The literature on neoplasms development in the course of therapy following transplants has confirmed a considerable increase in the incidence of neoplasms of the skin and lymph nodes. Organ neoplasms developing in patients after transplants are characterized by increased progression, poor cellular diversification and a more unfavorable prognosis than in the general population The aim of the study is to present the case of a nephron–sparing surgery of a renal tumor (NSS) without any intraoperative ischaemia in a 55–year–old female patient with an orthotopic heart transplant and renal insufficiency following a prolonged immune suppression. It is estimated that the patients at the highest risk of neoplasm development are those in the first months after transplant, especially heart transplant. They require maximum doses of immunosuppressive drugs. In the case of patients with initial renal insufficiency the duration of ischaemia of the organ operated on should be minimized, and if possible, surgery should be conducted without clamping the renal pedicle. The surgical treatment of RCC (renal cell carcinoma) in transplant patients does not require any reduction in the amount of the immunosuppressive drugs.
- Published
- 2013
28. Tension-Free Vaginal Tape, Transobturator Tape, and Own Modification of Transobturator Tape in the Treatment of Female Stress Urinary Incontinence: Comparative Analysis
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Wacław Kuczmik, Andrzej Paradysz, Krzysztof Nowakowski, Piotr Bryniarski, Zbiegniew Kaletka, Marcin Zyczkowski, Bartosz Muskała, and Tomasz Urbanek
- Subjects
Transobturator tape ,Study groups ,medicine.medical_specialty ,Article Subject ,Urinary Incontinence, Stress ,Operative Time ,Urodynamic studies ,lcsh:Medicine ,Urinary incontinence ,Prosthesis Design ,Single Center ,General Biochemistry, Genetics and Molecular Biology ,Comparative evaluation ,Postoperative Complications ,Risk Factors ,Humans ,Medicine ,Suburethral Slings ,General Immunology and Microbiology ,business.industry ,lcsh:R ,Tension free vaginal tape ,General Medicine ,Length of Stay ,Middle Aged ,Surgery ,Equipment Failure Analysis ,Catheter ,Treatment Outcome ,Female ,Poland ,medicine.symptom ,business ,Research Article - Abstract
Introduction. This study is a comparative evaluation of the TVT, TOT, and our own modification of TOT (mTOT) in the treatment of female stress urinary incontinence from a single center experience.Material and Methods. The study was conducted on 527 patients with SUI diagnosed on the basis of urodynamic studies. They were divided into three groups—TVT:n=142, (TOT):n=129, and mTOT:n=256. All of the patients underwent evaluation at 1, 3, and 6 months after surgery. Results were statistically analysed and compared.Results. Objective and subjective effectiveness after the surgery were not significantly different in the study groups and ranged from 90.1% to 96.4%. Mean surgery time was 32.3, 28.2, and 26.4 in the TVT, TOT, and mTOT, respectively. Mean hospitalization time was 2.51 days. Mean catheter maintenance time was significantly higher in the TVT than in other groups. In the TVT group total incidence of complications was 13.4%, and it was significantly higher than that in TOT and mTOT (9.3% and 8.6%, resp.).Conclusions. TVT, TOT, and mTOT are highly effective and safe methods in the treatment of SUI. There are no differences in the efficacy between the methods with a little higher percentage of complications in the TVT group.
- Published
- 2014
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29. Testicular volume and fertility potential in men operated due to varicocele and testicular hypotrophy in adolescence
- Author
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Andrzej Paradysz, Marcin Zyczkowski, Bartosz Muskała, Piotr Taborowski, Jacek Huk, Piotr Bryniarski, Zbigniew Kaletka, Mieczysław Fryczkowski, and Grzegorz Prokopowicz
- Subjects
Gynecology ,Surgical repair ,varicocele ,medicine.medical_specialty ,endocrine system ,Original Paper ,medicine.diagnostic_test ,Testicular vein ,business.industry ,media_common.quotation_subject ,Varicocele ,Urology ,laparoscopy ,Fertility ,testicular hypotrophy ,General Medicine ,medicine.disease ,Male infertility ,medicine.vein ,Concomitant ,medicine ,Abnormality ,Laparoscopy ,business ,media_common - Abstract
Introduction Failure to perform surgical repair of varicocele before puberty is among the common causes of male infertility. The purpose of this study was to evaluate the testicular volume and fertility potential in men after laparoscopic varicocelectomy conducted in adolescence due to varicocele and concomitant testicular hypotrophy. Material and methods From 1996 through 2011, eighty-two adolescents were operated on for unilateral primary varicocele with testicular hypotrophy. Sixty-eight patients were subject to the current analysis. The age of the patients was 13 to 17 years (mean 15.3 years). Clinical diagnosis was established on the basis of andrologic examination and ultrasonography with an assessment of testicular size and varicocele severity. Laparoscopic surgical repair was performed by a transperitoneal approach with division of testicular vein only. Results An increase in left testicular volume when compared with the contralateral testis was found in 25 (78.1%) young men with clinical grade 2 varicocele (p = 0.02) and in 32 (88.8%) subjects with grade 3 abnormality (p = 0.04). An increase in left testicular volume was found in 46 (85.1%) of 54 patients with unilateral varicocele and in 12 (85.7%) of 14 subjects operated on for bilateral disease. A left testicular volume increase was comparable independent of the use of uni- or bilateral repair. Fifty-eight (85.2%) of our 68 patients had normozoospermia. Conclusions Laparoscopic varicocele repair resulted in a significant increase of hypotrophic testicular volume in 83.8% of our subjects.
- Published
- 2012
30. Prognostic value of radical cystoprostatectomy in men with bladder cancer infiltrating prostate versus co-existing prostate cancer: a research study
- Author
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Piotr Bryniarski, Krzysztof Pliszek, Zbigniew Kaletka, Mieczysław Fryczkowski, Andrzej Paradysz, Paweł Pawlaczek, and Grzegorz Prokopowicz
- Subjects
Biochemical recurrence ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Urology ,Biopsy ,Urinary Bladder ,Kaplan-Meier Estimate ,Cystectomy ,lcsh:RC870-923 ,Cystoprostatectomy ,Prostate cancer ,Prostate ,medicine ,Humans ,Neoplasm Invasiveness ,Aged ,Neoplasm Staging ,Prostatectomy ,Urinary bladder ,Bladder cancer ,business.industry ,Muscles ,Prostatic Neoplasms ,Neoplasms, Second Primary ,General Medicine ,Middle Aged ,Prostate-Specific Antigen ,medicine.disease ,Prognosis ,lcsh:Diseases of the genitourinary system. Urology ,Prostate-specific antigen ,medicine.anatomical_structure ,Reproductive Medicine ,Urinary Bladder Neoplasms ,Lymphatic Metastasis ,business ,Follow-Up Studies ,Research Article - Abstract
Background The aim of the following study is to evaluate the advancement of incidentally diagnosed prostate cancer in specimen after cystoprostatectomies caused by muscle-invasive bladder cancer. Secondly we assessed the survival in patients after radical cystoprostatectomy whose postoperative specimen was characterized by the presence of co-existing prostate cancer or prostate infiltration by urothelial bladder cancer. Methods Between 1993 and 2009 a total of 320 patients with muscle-invasive bladder cancer underwent cystoprostatectomy. The first analyzed group consisted of 52 patients with bladder cancer infiltrating prostate, while the second group consisted of 21 patients with co-existing prostate cancer. In all patients cancer specific survival and progression were analyzed. Average follow up was 75.2 months (range: 0 - 181). Results Cancer-specific survival was significantly shorter in group I (p = 0.03). Neoplastic progression in patients from group I was observed in 42.2% of patients, while in patients from group II in 23.6% of patients (p = 0.04). No statistical difference was observed in the percentage of positive lymph nodes between the groups (p = 0.22). The median Gleason score in patients with co-existing prostate cancer was equal to 5. The stage of prostate cancer pT2/pT3 was equal to 20 (96%)/1 (4%) patients. 12 (57%) prostate cancers were clinically insignificant. Biochemical recurrence occurred in 2 (9%) patients. Conclusions 1. Incidentally diagnosed prostate cancer in specimen after cystoprostatectomies is frequently clinically insignificant and characterized by low progression. 2. Patients with bladder cancer infiltrating prostate are characterized by higher percentage of progression and death in comparison with patients with co-existing prostate cancer.
- Published
- 2010
31. Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells
- Author
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Wojciech Król, Lukasz Sedek, Ewelina Szliszka, Andrzej Paradysz, Bogdan Mazur, and Zenon P. Czuba
- Subjects
Male ,Chalcone ,Pharmacology ,Article ,Catalysis ,lcsh:Chemistry ,TNF-Related Apoptosis-Inducing Ligand ,Inorganic Chemistry ,chemistry.chemical_compound ,Prostate cancer ,Annexin ,Cell Line, Tumor ,Anticarcinogenic Agents ,Humans ,chemoprevention ,Medicine ,Cytotoxic T cell ,Physical and Theoretical Chemistry ,Cytotoxicity ,lcsh:QH301-705.5 ,Molecular Biology ,Spectroscopy ,Butein ,Dose-Response Relationship, Drug ,chalcones ,business.industry ,Organic Chemistry ,apoptosis ,Prostatic Neoplasms ,General Medicine ,prostate cancer ,medicine.disease ,Computer Science Applications ,lcsh:Biology (General) ,lcsh:QD1-999 ,chemistry ,Apoptosis ,Cancer cell ,TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) ,business - Abstract
Chalcones exhibit chemopreventive and antitumor effects. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a naturally occurring anticancer agent that induces apoptosis in cancer cells and is not toxic to normal cells. We examined the cytotoxic and apoptotic effect of five chalcones in combination with TRAIL on prostate cancer cells. The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was determined using flow cytometry with annexin V-FITC. Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.
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- 2009
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32. Complications following endoscopic treatment of vesicoureteric reflux with Deflux® – two case studies
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Marcin Zyczkowski, Wojciech Zajęcki, Grzegorz Prokopowicz, and Andrzej Paradysz
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,UTI ,Urology ,Urinary system ,Reflux ,vesicoureteral reflux ,complication ,Case Reports ,General Medicine ,medicine.disease ,Vesicoureteral reflux ,Endoscopy ,Surgery ,medicine ,Vesicoureteric reflux ,Deflux® ,Dextranomer ,endoscopy ,business ,Complication ,Endoscopic treatment ,medicine.drug - Abstract
The endoscopic injection of vesicoureteric orifices with synthetic or natural materials is a widely recognized method of treating vesicoureteral reflux (VUR). The aim of this study is to present two cases of clinically significant complications following the use of dextranomer/hyaluronic acid copolymer, which led to the progression of the reflux degree, permanent infection of the urinary tract, and the necessity to perform surgical treatment.
- Published
- 2012
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