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O objetivo deste trabalho foi avaliar o desempenho fisiológico e bioquímico de sementes de trigo produzidas em diferentes estados do Brasil. Este estudo foi conduzido em delineamento de blocos casualizados com 11 tratamentos dispostos em três repetições. A análise de variância revelou significância para Germinação (G), Velocidade de germinação (GS), Envelhecimento acelerado (AA), Comprimento da raiz (RL), Velocidade de emergência (ES), Comprimento da plântula (SL), Massa de mil sementes (TSM), Peso hectolitro (HW), Área foliar (LA), Teor de proteína (PTN), lipídios (LIP), fibra bruta (FB), cinzas (CNZ), amido (AMD), carboidratos totais (CT) e carboidratos não fibrosos (CNF). As sementes da cultivar TBIO Audaz oriundas de Brasília apresentaram qualidade superior, com maior vigor no teste de envelhecimento acelerado, comprimento da parte aérea e velocidade de emergência, sendo também a cultivar com maior teor de amido. Dentre os materiais estudados, verifica-se que independente da cultivar e local de produção das sementes de trigo existe uma associação positiva entre os atributos bioquímicos e físicos que influenciam na qualidade fisiológica do trigo, destacando-se o teor de amido, fibra e material mineral, bem como - massa de mil sementes, germinação, vigor e comprimento de plântulas.

O Carcinoma sebáceo é um tumor maligno, agressivo e raro, proveniente do epitélio de glândulas sebáceas, mais comumente localizado na cabeça e pescoço. É mais comum no sexo feminino, em paciente idosas, podendo simular patologias oftalmológicas. Sua etiologia não é bem definida, apresentando-se de forma isolada ou associada a Síndrome de Muir-Torre, doença autossômica dominante, em que o carcinoma sebáceo está associado a neoplasias viscerais, mais frequentemente tumores gastrointestinais. O objetivo desse trabalho é relatar o caso de uma paciente com lesão vegetante em pálpebra inferior esquerda, cujo diagnóstico foi conclusivo para carcinoma sebáceo. Diante disso, foi realizada a busca ativa por neoplasias viscerais, estabelecendo-se o diagnóstico de tumor de sigmoide.

In this paper we engage in a critical exploration of the strategic use of weaponised and glorified media representations of children and (re)production in anti-gender and pro-family movements. We argue that this strategy aims to portray the heteronormative family as the “natural” aim, the normal (normative) condition of living, and the only acceptable social engagement in society. We analyse these semantic representations through three theoretical lenses: anti-social queer theory, children’s rights theory, and intersectional feminism. These inform and share the critical discourse analysis (Fairclough 2013) of media documentation of two recent events in Italy: the pro-family conference “The Wind of Change: Europe and the Global Pro-Family Movement”, which took place in Verona in March 2019; and the reactionary far-right and ultra-Catholic campaigns in response to the updated guidelines for the application of the Abortion Law 194, in regard to the administration of the abortion pill (RU486) in August 2020. We review three recurrent concepts in the rhetoric of the anti-gender and pro-family movements discussed in the analysed media articles: the Child; reproductive futurism; and the glorification of hetero-normative modes of socialisation, discussed here as “positive sociality”. In exploring the ideological discourses presented in relation to these concepts, we adopt Bersani’s (1995) critique of heteronormative practices as a starting point. Findings highlight the modality in which anti-gender and pro-family movements utilise these three ideological concepts as weapons to define non-normative sociality as a threat to the traditional (and reproductive) family as well as the (white) nation.

por ser relato de experiência, as normas da revista não requerem resumo

Comparou-se os estoques de C e N em Latossolo Vermelho sob Floresta Estacional Semidecidual (FN), pastagem convencional (P) e sistema de integração pecuária-floresta (IPF). Coletaram-se amostras de solo em subcamadas até 100 cm de profundidade, após 5 anos da implantação dos sistemas produtivos. O solo do IPF apresentou estoque de C, na camada de 0 a 30 cm, 39% e 23% menor do que no solo da FN e da P, respectivamente. Com 3,2 Mg ha-1 de N o solo do IPF continha menor estoque na camada de 0 cm a 30 cm em relação ao solo da P (4,7 Mg ha-1 de N). Na camada de 0-100 cm não houve diferença nos estoques de C entre os tratamentos, mas o IPF apresentou o menor estoque de N. Os sistemas produtivos necessitam de medidas adicionais de manejo para potencializar o acúmulo de C e N no solo, entre as quais, reposição de nutrientes, adequado manejo da pastagem e melhores práticas silviculturais no IPF, visando reduzir o grau de sombreamento. Isto trará sustentabilidade aos sistemas, minimizando a perda de C e N para a atmosfera, na forma de GEE, um dos fatores que colabora para as mudanças do clima.

Slow-release urea fertilisers have been shown to present acceptable values for plant yield and mitigate the harmful effect of soil emission gases. This study synthesises a slow-release fertiliser containing fumed-nanosilica, nanofibrillated cellulose as well as sodium alginate as a urea carrier to analyse the growth parameters of Eucalyptus urograndis seedlings and potential emission of soil gases, N

Background In the field of neurorehabilitation, robot-assisted therapy (RAT) and virtual reality (VR) have so far shown promising evidence on multiple motor and functional outcomes. The related effectiveness on patients’ health-related quality of life (HRQoL) has been investigated across neurological populations but still remains unclear. The present study aimed to systematically review the studies investigating the effects of RAT alone and with VR on HRQoL in patients with different neurological diseases. Methods A systematic review of the studies evaluating the impact of RAT alone and combined with VR on HRQoL in patients affected by neurological diseases (i.e., stroke, multiple sclerosis, spinal cord injury, Parkinson’s Disease) was conducted according to PRISMA guidelines. Electronic searches of PubMed, Web of Science, Cochrane Library, CINAHL, Embase, and PsychINFO (2000–2022) were performed. Risk of bias was evaluated through the National Institute of Health Quality Assessment Tool. Descriptive data regarding the study design, participants, intervention, rehabilitation outcomes, robotic device typology, HRQoL measures, non-motor factors concurrently investigated, and main results were extracted and meta-synthetized. Results The searches identified 3025 studies, of which 70 met the inclusion criteria. An overall heterogeneous configuration was found regarding the study design adopted, intervention procedures and technological devices implemented, rehabilitation outcomes (i.e., related to both upper and lower limb impairment), HRQoL measures administered, and main evidence. Most of the studies reported significant effects of both RAT and RAT plus VR on patients HRQoL, whether they adopted generic or disease-specific HRQoL measures. Significant post-intervention within-group changes were mainly found across neurological populations, while fewer studies reported significant between-group comparisons, and then, mostly in patients with stroke. Longitudinal investigations were also observed (up to 36 months), but significant longitudinal effects were exclusively found in patients with stroke or multiple sclerosis. Finally, concurrent evaluations on non-motor outcomes beside HRQoL included cognitive (i.e., memory, attention, executive functions) and psychological (i.e., mood, satisfaction with the treatment, device usability, fear of falling, motivation, self-efficacy, coping, and well-being) variables. Conclusions Despite the heterogeneity observed among the studies included, promising evidence was found on the effectiveness of RAT and RAT plus VR on HRQoL. However, further targeted short- and long-term investigations, are strongly recommended for specific HRQoL subcomponents and neurological populations, through the adoption of defined intervention procedures and disease-specific assessment methodology.

The nutritive value of a dual purpose forage, its structural and morphological composition, seed production capacity are determining characteristics in the selection of a genotype. The objective of this work was to evaluate the effect of cutting management on yield components, physiological quality of the seeds in the subsequent generation. Experiment I: the field cutting management was performed, and the yield components and the physiological quality of the seeds were evaluated. Experiment II: where the components of plant yield and physiological quality of the seeds were evaluated. The cutting managements affect the components of yield, such as thousand seed weight and seed mass per cob, as well as germination, first germination count and seedling dry mass of dual purpose wheat. In the generation that evaluates the quality of the seeds produced, the cuts do not influence the physiological quality of the seeds, however, they affect the yield components, number of cobs per plant, one thousand seed weight and seed mass per cob.

COVID-19 has required a significant and abrupt shift in the way we teach and learn in the field of Higher Education (HE). This paper explores an innovation in pedagogy in HE as lecturers and students transition from learning on campus to learning online. The transition to online learning, in this context, is problematised within the broader context of digital exclusion and the significance of foregrounding students' needs. The reflections presented in this paper derive from a re-envisioned undergraduate final year research project module delivered to a large diverse cohort of students (100+). In this module we applied premises underpinning authentic pedagogy, bringing the challenges faced by learners to the foreground whilst privileging student agency, autonomy, and competency. An element of the module previously delivered through in-person group supervisions was reconfigured into one-hour online workshops structured through a cycle of opportunities for participation. In our reflections we identify that students' agency, the promotion of social int eraction, and continuity in pedagogy were key elements in enabling the formation of a community of learning.

Resumo: Esta pesquisa tem o objetivo de identificar e classificar situações do tipo misto, associadas à função afim, presentes em provas do Enem. Foram analisadas as provas do Enem da edição de 2020 e foram identificadas 10 situações possíveis de serem escritas na forma f ( x ) = a x + b . Cada situação foi analisada quanto à apresentação dos dados, estrutura de resolução e classificadas com base na combinação das classes dos campos conceituais aditivos e multiplicativos, conforme propostos na teoria dos campos conceituais, que embasa esta pesquisa. Dentre as classes identificadas, a mais frequente foi dupla proporção simples e composição de medidas, com três situações. Para parte dos estudantes que presta o Enem, o acesso ao saber matemático é oriundo da sala de aula, logo, conhecer as diferentes classes de situações do tipo misto é do interesse do professor para proporcionar a seus alunos a construção do conceito de função afim. Abstract: This research aims to identify and classify mixed-type situations, associated with the affine function, present in Enem tests. The 2020 Enem tests were analyzed and 10 possible situations were identified to be written in the form f ( x ) = ax + b . Each situation was analyzed in terms of data presentation, resolution structure, and classified based on the combination of classes of additive and multiplicative conceptual fields, as proposed in the Conceptual Fields theory, which supports this research. Among the classes identified in the corpus, the most frequent one was simple double proportion and composition of measures, with three situations. For most students who take Enem, access to mathematical knowledge comes from the classroom; therefore, knowing the different classes of mixed-type situations is in the teacher's interest to provide students with the construction of the concept of the affine function.

Burns; Disaster planning; European Union Quemaduras; Planificación de desastres; Unión Europea Cremades; Planificació de desastres; Unió Europea Background Burn care is centralized in highly specialized burn centers in Europe. These centers are of limited capacity and may be overwhelmed by a sudden surge in case of a burn mass casualty incident. Prior incidents in Europe and abroad have sustained high standards of care through well-orchestrated responses to share the burden of care in several burn centers. A burn mass casualty incident in Romania in 2015 sparked an initiative to strengthen the existing EU mechanisms. This paper aims to provide insight into developing a response plan for burn mass casualties within the EU Civil Protection Mechanism. Methods The European Burns Association drafted medical guidelines for burn mass casualty incidents based on a literature review and an in-depth analysis of the Romanian incident. An online questionnaire surveyed European burn centers and EU States for burn mass casualty preparedness. Results The Romanian burn mass casualty in 2015 highlighted the lack of a burn-specific mechanism, leading to the late onset of international transfers. In Europe, 71% of respondents had existing mass casualty response plans, though only 35% reported having a burn-specific plan. A burns response plan for burn mass casualties was developed and adopted as a Commission staff working document in preparation for further implementation. The plan builds on the existing Union Civil Protection Mechanism framework and the standards of the WHO Emergency Medical Teams initiative to provide 1) burn assessment teams for specialized in-hospital triage of patients, 2) specialized burn care across European burn centers, and 3) medevac capacities from participating states. Conclusion The European burn mass casualty response plan could enable the delivery of high-level burn care in the face of an overwhelming incident in an affected European country. Further steps for integration and implementation of the plan within the Union Civil Protection Mechanism framework are needed. This work was supported by funding from the European Commission, Directorate-General for European Civil Protection and Humanitarian Aid Operations (ECHO), Directorate B - Disaster Preparedness and Prevention, Unit B1 - Civil Protection Horizontal Issues by tender contract ECHO-B1-NP-2019-05 regarding a European response to mass burn casualty disasters.

Pequenos Oceanos é um ensaio visual que apresenta uma série de vinte e quatro pinturas. A série trata de distância e deslocamento. As pinceladas criam camadas longas de texturas que fazem nascer um pequeno espaço vazio. O vazio também é a falta. A falta é saudade, é um oceano inteiro que distancia.

A nutrição é um fator limitante na produção e qualidade de sementes de cevada. Nesse sentido, é necessário um adequado suprimento de nitrogênio para a obtenção de produtividade e qualidade fisiológica de sementes. Assim, o objetivo desse trabalho foi avaliar as respostas de duas cultivares de cevada, BRS Brau e BRS Cauê, em diferentes doses de adubação nitrogenada, inferindo sobre a produtividade e a qualidade fisiológica nas diferentes situações. O delineamento experimental utilizado foi de blocos ao acaso, em esquema fatorial 2x4, (duas cultivares X quatro doses de nitrogênio) e os tratamentos consistiram na combinação de duas cultivares (BRS Cauê e BRS Brau) e quatro doses de nitrogênio, totalizando oito tratamentos. O experimento foi conduzido no município de Capão do Leão e a coleta de dados para avaliação da resposta das plantas às doses de nitrogênio quanto ao rendimento e qualidade fisiológica de sementes de cevada, foram analisados no Laboratório de Análise de Sementes do Programa de Pós-Graduação em Ciência e Tecnologia de Sementes. As cultivares BRS Brau e BRS Cauê apresentaram diferentes exigências de nitrogênio para as variáveis altura de planta, rendimento por planta e rendimento total. Em relação à qualidade fisiológica de sementes, a utilização de diferentes doses de nitrogênio não afetou significativamente a germinação e o vigor das sementes. Porém, para as expressões isoenzimáticas, as diferentes doses de adubação nitrogenada influenciaram as plântulas de cevada. Palavras-chave: Hordeum vulgare; adubação nitrogenada; qualidade fisiológica; expressões isoenzimáticas.

O transplante pulmonar é uma opção terapêutica com alto potencial para o tratamento de diversas pneumopatias avançadas, levando ao receptor sobrevida e uma melhor qualidade de vida. No entanto, diferente dos outros órgãos sólidos, no transplante pulmonar vemos um cenário onde existe uma carência na oferta de órgão doador e uma alta demanda para o transplante. Essa carência ocorre pela falta de doadores adequados nos critérios de seleção, pois devido às agressões ao pulmão ocasionadas pela morte encefálica e aos cuidados na UTI, leva a uma não viabilidade da doação do órgão e como consequência um aumento desproporcional na fila de espera. Ademais, existem propostas tecnológicas para aumentar a oferta de pulmões. A perfusão pulmonar ex vivo, é considerada uma proposta com bastante perspectiva por conseguir recuperar alguns pulmões que inicialmente eram descartados. É fundamental que a ciência continue demostrando constante evolução nas diversas etapas do transplante pulmonar, como aprimoramento nos métodos, no suporte pré, peri e pós operatório, no aumento da oferta pulmonar, com objetivo de aumentar a sobrevida e diminuir a carência de órgão doador. Além disso, é necessário o conhecimento dos critérios de indicação, contraindicação e do manejo para alcançar melhor resultados nessa opção terapêutica para pneumopatias avançadas

The objective was to evaluate the effects of different harvest times and storage periods on the physiological quality of amaranth seeds of the cultivar BRS Alegria. The quality of the seeds was evaluated in three moments of harvest, with intervals of 20 days and the period of storage, in four moments, at the moment of the harvest and other three evaluations in intervals of 30 days, in addition to evaluations of the isoenzymatic expression after two years of seed storage in a cold chamber. Variations in the physiological quality of amaranth seeds were observed at different harvest times and storage periods. Noting an important reduction in the physiological quality of the seeds when stored for 90 days.

Aims To conduct an overview and systematic evaluation of prospective cohort studies on whether alcohol intake is associated with the incidence and progression of periodontitis. Methods Nine databases were searched by two independent reviewers up to November 2021 according to prespecified eligibility criteria. Risk of Bias in Systematic Reviews and Risk of Bias in Non-Randomized Studies of Interventions were used for risk of bias assessment and certainty of evidence was assessed using the GRADE approach. Random-effects pair-wise meta-analyses were performed with data from cohort studies on the effects of higher levels of alcohol intake compared with current non-drinking to determine risk ratios (RR) and confidence intervals of periodontitis. Results The four systematic reviews were at high risk of bias and concluded that alcohol intake is associated with periodontitis regardless of the study design. Five reports from seven cohort studies contributed to the meta-analyses and no statistically significant differences were found for higher levels of consumption regarding the risk of periodontitis, except for men from countries with low- and high-middle socio-demographic index (RR = 1.30, 95% CI: 1.13–1.46), with low certainty evidence. Conclusion Higher levels of alcohol consumption seem to be part of the causal mechanism of periodontitis when cooccurring with male sex in underdeveloped countries. No conclusion can be drawn regarding alcohol use disorders or patterns of consumption.

Identificam-se neste estudo as contribuições da Psicopedagogia em cursos de língua inglesa na constituição de uma cultura escolar inclusiva de alunos com Transtorno do Déficit de Atenção (TDA). Para direcionar este artigo, definiu-se uma questão central formulada em torno da seguinte pergunta: de que modo a Psicopedagogia pode auxiliar a inclusão de alunos TDAs em curso de língua inglesa? Nesta direção, estabeleceram-se os tópicos abordados neste artigo a partir do objetivo geral que o norteou: identificar a contribuição da Psicopedagogia na inclusão de alunos TDAs em cursos de língua inglesa. O artigo fundamenta suas ideias nas contribuições teóricas de Alicia Fernández, sobre modalidades de aprendizagens; de Vygotsky, com a construção do ser biopsicossocial; de Fonseca, sobre as funções cognitivas da aprendizagem, além de outras contribuições de diversos especialistas em TDA. Busca-se, também, sob um ponto de vista mais amplo, contribuir com a democratização de outros ambientes de aprendizado, além das escolas regulares, bem como para a implantação de uma cultura escolar inclusiva através da atuação do Psicopedagogo. Como hipótese, considerou-se que o Psicopedagogo é o profissional que possui preparo adequado para formar uma equipe responsável por reformular o processo ensino-aprendizagem vigente nas instituições de ensino, de maneira a favorecer a inclusão, como também em cursos livres de inglês com intuito de vislumbrar a consolidação de uma cultura inclusiva, o que favorece a autonomia e a independência do aluno TDA. Trata-se de um estudo amparado em revisão bibliográfica, cujos resultados verificaram a importância do papel do Psicopedagogo como integrante de uma equipe que auxilia os professores e alunos TDAs em contextos do ensino/aprendizado da língua inglesa em cursos livres.

Nas últimas décadas o debate acerca da Justiça tomou novas matizes a partir do efervescer das reivindicações e bandeiras LGBTQIA+. Historicamente e naturalmente marginalizada, tal comunidade tem se estruturado com o objetivo de ter seus direitos, princípios e valores respeitados. Imbuído do interesse em compreender a omissão legislativa, falta de reconhecimento e ausência de efetividade dos direitos fundamentais dessa população, o artigo tenciona a analisar a luta pelo reconhecimento dos sujeitos LGBTQIA+, mediante o método dialético tripartite hegeliano, tomando-se como referencial o pensamento de Axel Honneth, que, ao expor seu posicionamento acerca da Justiça, propõe uma Teoria do Reconhecimento, a qual se revela em três esferas - amor, solidariedade e direito. Aspirando a concretização dos direitos fundamentais e construção de uma sociedade inclusiva e aquiescente às diferenças sexuais e de gênero.

Este artigo parte da premissa de que os ambientes construídos para a Educação Infantil podem ser intencionalmente planejados para atuarem como agentes educadores de bebês e crianças pequenas. Com base no estudo de caso de uma escola de Educação Infantil em Erechim/RS, a pesquisa teve por objetivo investigar as relações entre os ambientes (internos e externos) e a proposta pedagógica da instituição para, a partir delas, delinear algumas considerações sobre seus efeitos na concepção projetual de escolas infantis. A metodologia da pesquisa foi a Avaliação Pós-ocupação alinhada com a Abordagem Experiencial. A experiência de campo se desdobrou a partir de um Percurso Walkthrough, que evidenciou os efeitos da forma e da configuração das salas nos arranjos espaciais e na circulação das crianças. Observou-se que as características e disposição do mobiliário nas salas partem de uma intencionalidade pedagógica; que além das condições de conforto e bem-estar, as paredes, pisos, tetos e janelas podem (e devem) ser exploradas pedagogicamente; e que se concebido e configurado como um ambiente integrador, o pátio coberto atua como facilitador das brincadeiras e interações entre as crianças das diferentes faixas etárias. Enfim, os resultados confirmam a necessidade da concepção projetual atentar para a flexibilidade, de forma que os ambientes possam ser adaptados à abordagem pedagógica da escola e às propostas dos professores.

RESUMO A industrialização da agricultura e da pecuária, além de gerar um ambiente propício à disseminação de agentes infecciosos, é responsável pelo uso generalizado de diversas substâncias tóxicas que afetam a saúde humana, animal e ambiental. O objetivo deste estudo foi promover a reflexão sobre o uso de agrotóxicos e medicamentos veterinários como elementos de debate na construção da Saúde Única. Para isso, foi realizada uma revisão exploratória literária de artigos, livros e documentos oficiais disponíveis em plataformas de banco de dados. A discussão inclui as problemáticas do uso de substâncias tóxicas em plantas e animais. Aborda, também, como os resíduos oriundos de sua utilização impactam a qualidade de alimentos, ar, solo, água com consequências à saúde humana. Embora essa discussão seja escassa na temática de Saúde Única, é fundamental que, além da participação da sociedade civil organizada, gestores públicos assegurem, por meio de políticas públicas, maior segurança e controle na utilização de substâncias tóxicas na agricultura e na pecuária.

Background: Adverse neurological events during extracorporeal membrane oxygenation (ECMO) are common and may be associated with devastating consequences. Close monitoring, early identification and prompt intervention can mitigate early and late neurological morbidity. Neuromonitoring and neurocognitive/neurodevelopmental follow-up are critically important to optimize outcomes in both adults and children. Objective: To assess current practice of neuromonitoring during ECMO and neurocognitive/neurodevelopmental follow-up after ECMO across Europe and to inform the development of neuromonitoring and follow-up guidelines. Methods: The EuroELSO Neurological Monitoring and Outcome Working Group conducted an electronic, web-based, multi-institutional, multinational survey in Europe. Results: Of the 211 European ECMO centres (including non-ELSO centres) identified and approached in 23 countries, 133 (63%) responded. Of these, 43% reported routine neuromonitoring during ECMO for all patients, 35% indicated selective use, and 22% practiced bedside clinical examination alone. The reported neuromonitoring modalities were NIRS ( n = 88, 66.2%), electroencephalography ( n = 52, 39.1%), transcranial Doppler ( n = 38, 28.5%) and brain injury biomarkers ( n = 33, 24.8%). Paediatric centres (67%) reported using cranial ultrasound, though the frequency of monitoring varied widely. Before hospital discharge following ECMO, 50 (37.6%) reported routine neurological assessment and 22 (16.5%) routinely performed neuroimaging with more paediatric centres offering neurological assessment (65%) as compared to adult centres (20%). Only 15 (11.2%) had a structured longitudinal follow-up pathway (defined followup at regular intervals), while 99 (74.4%) had no follow-up programme. The majority ( n = 96, 72.2%) agreed that there should be a longitudinal structured follow-up for ECMO survivors. Conclusions: This survey demonstrated significant variability in the use of different neuromonitoring modalities during and after ECMO. The perceived importance of neuromonitoring and follow-up was noted to be very high with agreement for a longitudinal structured follow-up programme, particularly in paediatric patients. Scientific society endorsed guidelines and minimum standards should be developed to inform local protocols.

There is still a need for an efficient method for the isolation of extracellular vesicles (EVs) from human blood that provides a reliable yield with acceptable purity. Blood is a source of circulating EVs, but soluble proteins and lipoproteins hamper their concentration, isolation, and detection. This study aims to investigate the efficiency of EV isolation and characterization methods not defined as “gold standard”. EVs were isolated from human platelet-free plasma (PFP) of patients and healthy donors through size-exclusion chromatography (SEC) combined with ultrafiltration (UF). Then, EVs were characterized using transmission electron microscopy (TEM), imaging flow cytometry (IFC), and nanoparticle tracking analysis (NTA). TEM images showed intact and roundish nanoparticles in pure samples. IFC analysis detected a prevalence of CD63+ EVs compared to CD9+, CD81+, and CD11c+ EVs. NTA confirmed the presence of small EVs with a concentration of ~1010 EVs/mL that were comparable when stratifying the subjects by baseline demographics; conversely, concentration differed according to the health status across healthy donors and patients affected with autoimmune diseases (130 subjects in total, with 65 healthy donors and 65 idiopathic inflammatory myopathy (IIM) patients). Altogether, our data show that a combined EV isolation method, i.e., SEC followed by UF, is a reliable approach to isolate intact EVs with a significant yield from complex fluids, which might characterize disease conditions early.

Pulmonary arterial hypertension (PAH) is a life-threatening complication of connective tissue diseases (CTDs) characterised by increased pulmonary arterial pressure and pulmonary vascular resistance. CTD-PAH is the result of a complex interplay among endothelial dysfunction and vascular remodelling, autoimmunity and inflammatory changes, ultimately leading to right heart dysfunction and failure. Due to the non-specific nature of the early symptoms and the lack of consensus on screening strategies—except for systemic sclerosis, with a yearly transthoracic echocardiography as recommended—CTD-PAH is often diagnosed at an advanced stage, when the pulmonary vessels are irreversibly damaged. According to the current guidelines, right heart catheterisation is the gold standard for the diagnosis of PAH; however, this technique is invasive, and may not be available in non-referral centres. Hence, there is a need for non-invasive tools to improve the early diagnosis and disease monitoring of CTD-PAH. Novel serum biomarkers may be an effective solution to this issue, as their detection is non-invasive, has a low cost and is reproducible. Our review aims to describe some of the most promising circulating biomarkers of CTD-PAH, classified according to their role in the pathophysiology of the disease.

Coronavirus disease 2019 (COVID-19) is a disease produced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is currently causing a catastrophic pandemic affecting humans worldwide. This disease has been lethal for approximately 3.12 million people around the world since January 2020. Globally, among the most affected countries, Mexico ranks third in deaths after the United States of America and Brazil. Although the high number of deceased people might also be explained by social aspects and lifestyle customs in Mexico, there is a relationship between this high proportion of deaths and comorbidities such as high blood pressure (HBP), type 2 diabetes, obesity, and metabolic syndrome. The official epidemiological figures reported by the Mexican government have indicated that 18.4% of the population suffers from HBP, close to 10.3% of adults suffer from type 2 diabetes, and approximately 36.1% of the population suffers from obesity. Disbalances in the gut microbiota (GM) have been associated with these diseases and with COVID-19 severity, presumably due to inflammatory dysfunction. Recent data about the association between GM dysbiosis and metabolic diseases could suggest that the high levels of susceptibility to SARS-CoV-2 infection and COVID-19 morbidity in the Mexican population are primarily due to the prevalence of type 2 diabetes, obesity, and metabolic syndrome.

As malformações arteriovenosas (MAVs) são compostas por artérias e veias dilatadas diretamente ligadas por micro e macrofístulas hemodinamicamente ativas de alto fluxo e, diferentemente dos hemangiomas, não sofrem involução espontânea, sendo permanentes e caracterizadas por crescimento que acompanha o crescimento do indivíduo, podendo se agravar ao longo da vida do paciente por meio da dilatação progressiva dos vasos malformados. Clinicamente, se apresentam como uma nodulação revestida pela epiderme íntegra ou angiomatosa, com calor na região e podendo existir frêmito e sopro no local, sendo que com a progressão da MAV, as veias de drenagem distendem e podem se tornar evidentes. O artigo relata o caso de uma paciente feminina dde 38 anos com queixa de massa pulsátil crescente em região mentoniana direita da face. Ao exame físico, observava-se massa subcutânea em região mentoniana direita da face medindo cerca de 2,5cm de diâmetro, indolor à palpação, com frêmito ao toque e sopro à ausculta, sem alterações cutâneas ou sinais flogísticos.

Visceral leishmaniasis (VL) is an endemic disease in the region of Gurupi, with higher prevalence in the pediatric age group, aggravated by the high morbidity and low prophylaxis and prevention strategies of this anthropozoonosis. Objective: To characterize the data reported in the municipality of Gurupi - TO in the years 2013 to 2020 and to outline the epidemiological profile of the disease by determining the risk factors for high prevalence of the disease in this locality. Methods: This is a cross-sectional descriptive epidemiological research, retrospective and documental based, extracted from the database of SINAN (Notifiable Diseases Information System) of Gurupi in the interval between 2013 and 2020. Evaluative questionnaires were applied to all patients notified and found, analyzing the variables described in the study and subsequent statistical application of the chi-square test. Results: In the city of Gurupi, the most affected age group was between 2 and 9 years (37.29%); the most affected gender was male (66.10%); the year of highest prevalence was the year 2017 a total of 37.28% of cases in the analyzed period; and the location of highest prevalence in the municipality were the neighborhoods farthest from the city center. As for the probable sites for contamination, most people point to their own home as a source of contamination. Conclusion: The epidemiological cut shows the prevalence of VL in the city of Gurupi and highlights the need for preventive intervention protocols for the prevention of the disease in endemic areas to decrease morbidity and mortality and control the number of cases.

Storage is a factor that can affect seed quality as a function of latent damages. The losses that most contribute to the reduction in germination and vigor during storage are those caused by humidity, mechanical and temperature-related, that may interfere with seed quality throughout storage. The aim of this study was evaluating the physiological quality of maize seeds produced in two environments and classified in different formats compared to storage periods. The experiment was carried out in the 2016 harvest in two cultivation environments: Entre-Ijuís, RS and Pelotas, RS. Seeds were stratified by thickness through sieves with oblong holes and stratified into small round, large round, small flat and large flat. Growing environments influence the physiological characteristics of maize seeds. The flat and large format seeds have superior physiological quality for the measured physiological characters. The small and round seeds present lower values for germination, first germination count, emergence speed index, shoot dry matter of emergence seedlings and shoot dry matter of germination seedlings. Corn seeds when stored under controlled conditions remain for long periods without causing decreases in physiological quality.

Após passar por uma etapa de estudo e levantamentos dos vetustos monumentos romanos, acompanhando leituras e discussões teórico-artísticas promovidas pela Accademia della Virtú (c.1542) em Roma, Iacomo Barozzi da Vignola redigiu duas obras que permitem situá-lo entre os importantes teóricos do período. A exemplo de Sebastiano Serlio (1475-1554) e Guillaume Philandrier (1505-1563) que partiram do estudo do De Architettura de Vitrúvio (I séc. a. C.) e da observação das ruinas para compor os seus tratados, Barozzi deu sua contribuição à Teoria das Ordens com seu Regole delli Cinque ordine d’ Architettura, 1562. Diferentes estudos sobre as raízes da Arte têm levado àcompreensão de o Brasil não esteve alheio à difusão do Livro de Figuras de Vignola.

O ensino superior deve oferecer aos universitários oportunidades de se tornarem agentes morais, cujos parâmetros decisórios devem ser balizados por princípios éticos, caso contrário os atores sem poder de decisão, denominados de pacientes morais, podem se tornar vulneráveis. O objetivo da pesquisa foi levantar a linha de base dos fenômenos “cães abandonados” e “acumuladores de animais” em mídias populares (Estudo I) e avaliar a percepção dessa temática e nível de moralidade de universitários (Estudo II). Realizou-se uma pesquisa quali-quantitativa transversal por meio de análise do conteúdo veiculado nas mídias digitais e da participação em questionário. Os principais resultados do Estudo I, refletiram o padrão imediatista contemporâneo de enfrentamento de problemas complexos utilizando-se de procedimentos paliativos, nos quais é enaltecido o problema e não os valores e crenças do agente moral. No Estudo II, a maioria dos 160 respondentes possui cães de estimação e percebem os animais errantes, porém suas argumentações ainda refletem os estágios iniciais do desenvolvimento moral, tendendo para o senso comum e refletindo mais o teor das notícias, ao invés de representarem reflexões amadurecidas. Conclui-se que o entendimento da necessidade do bem-estar dos animais e das pessoas, não foi permeado pela compreensão de valores e princípios éticos, mas, todavia, são expressões de suas emoções evidenciando a não internalização dos princípios éticos, sendo os atos julgados pelas consequências, demandando a intervenção de programas educativos.

Introduction Prenatal ultrasound diagnosis of anorectal malformations (ARMs) is challenging and often missed as direct visualization of the anal sphincter is not routinely performed, plus the technique is operator-dependent and inaccurate, also in expert hands. Other indirect signs, such as rectosigmoid overdistension or intraluminal calcifications, are occasionally present in late pregnancy. The detection of a cyst of the lower abdomen in the first trimester may be an early sign of ARM. Here we reported our experience and a review of the literature of such cases. Material and methods Isolated cases of lower abdomen cysts encountered in the first trimester at the Prenatal Diagnosis Unit during the last 5 years were retrieved and compared with those found in literature. Post-natal clinical data were analyzed to check the presence and type of malformations. Results A total of three cases of lower abdomen cysts were found in our center and 13 in literature. In our case series all the cysts spontaneously regressed and were no longer visible since the second trimester of pregnancy, while in literature this was reported in only 4 out of 13 cases. ARM was confirmed in all patients at birth or post-mortem. Conclusions The finding of a lower abdomen cyst during the first trimester of pregnancy could be an early predictive sign of ARM, even if it disappears during pregnancy. In these cases, we suggest mentioning to the parents the possibility of an ARM during the counseling and to refer the couple to a Colorectal Center. Graphical Abstract

A new alternative aerogel was prepared from low-cost chitin and psyllium biopolymers to adsorb crystal violet (CV) dye from liquid media and possibly treat effluents containing other dyes. The aerogel was characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM), which demonstrated that aerogel has a typical structure of amorphous materials and presented a randomly interconnected porous structure that resembles an open pore network. 2.5 g L−1 of aerogel was able to remove 86.00% of CV from solutions, and the natural pH of the CV solution was considered the more adequate for adsorption. The pseudo-second-order (PSO) model satisfactorily described the adsorption kinetics, and the Freundlich model was suitable to represent the adsorption equilibrium. The maximum experimental capacity achieved was 227.11 mg g−1, which indicates that aerogel is very efficient and competitive with several adsorbents. Tests using a simulated effluent showed that aerogel has excellent potential to treat real colored effluents.

The aimed to evaluate the influence of different glyphosate formulations in nodulation, agronomic performance and RR soybean seeds yield, grown in two sowing periods. The experimental design was the casualized blocks with treats disposed in four replicates, being organized in factorial scheme, two seeding periods x five glyphosate formulations. The measured characters were number of nodules per plant, number of active nodules, number of inactive nodules, height of the first legume insertion, plant height, number of legumes per plant, number of seeds per plant, mass of thousand seeds and yield of seeds per plant. The isopropylamine salt influences nodular activity, number of vegetables and seeds per plant, as well as seed yield. The sowing of soybeans at the recommended time propitiates smaller modifications face to glyphosate formulations. mulations.

Purpose Women with anorectal malformation (ARM) are expected to have a normal life span, therefore, gynecological and psycho-sexual issues are also important. Aim of the study was to assess these aspects in adult females with history of ARM. Methods Thirty-seven women from two ARM referral centers, aged ≥ 16, were identified. Gynecologic visit, cervicovaginal swab, pelvic ultrasound, FSH, LH, prolactin, progesterone, 17–β–estradiol, DHEAS, testosterone, TSH during follicular and luteal phases, and administration of FSFI questionnaire to screen the female sexual functioning were performed. Data were compared with six controls. Results Nineteen patients, mean age 21.7 (16–45), participated to the study. Associated anomalies, mostly affecting limbs, vertebrae and genitalia, were present in 57.8% of cases. Mullerian anomalies were retrieved in 36.8%. Hormones’ levels were normal. Concerning sexual functioning, four women (21%) reported dyspareunia or impossible penetration, four did not answer the FSFI questionnaire due to lack of confidence about their sexuality, and three scored lower than the cut-off value for female sexual function. Conclusion This study confirms the importance of a multidisciplinary long-term follow-up for ARM patients, including a careful study of the reproductive tract to detect and treat those conditions that could affect the fertility. Moreover, an appropriate psychological support should be provided.

Molybdenum is the micronutrient required in less quantity by plants and found in lower concentrations in Brazilian soils. The study aimed to study the influence of the application of molybdenum (Mo) and potassium (K) via foliar feeding, at different phenological stages, on the quality of soybean seeds. The work was conducted in the field in the county of Coronel Bicaco, RS under the condition of a typical dystropheric red Latosol (Oxisol) soil, in the 2017/2018 season crop. The experimental design was randomized blocks in a factorial scheme phenological stages x cultivars. Analysis of variance revealed significance for the interaction between phenological stages x cultivars for the variables composed by germination, abnormal, hard, dead, as well as field emergence, plant length and root length. There is influence of foliar feeding of molybdenum (Mo) and potassium (K) in different phenological stages of soybean. It was found that there was no significant difference for the yield of soybean cultivars under foliar feeding of Mo and K in the different treatments to which they were submitted.

Venustaconcha ellipsiformis (Unionidae) is a freshwater mussel species inhabiting small to medium streams of the Midwestern United States; however, its occurrence is rather sporadic and populations are often isolated. Due to anthropogenic habitat degradation and water pollution, this species is designated as some sort of conservation status in many states. To prioritize conservation strategies, highly variable genetic markers are necessary to assess population genetic structure and potential genetic erosion of V. ellipsiformis. Using whole genome sequence data, we developed and characterized microsatellite markers for V. ellipsiformis. Among 23 tetranucleotide loci tested, 14 loci were consistently amplified and showed polymorphism. Analyses performed on three populations in the upper Mississippi River basin showed that the number of alleles per locus ranged from 2 to 11 and the observed heterozygosity varied from 0.15 to 0.75. Based on genotypic and allelic rarefaction curves, these loci had adequate statistical power to genetically discriminate between individuals and the sample size was large enough to capture most alleles available in the populations at most loci. Finally, cross-species screening of the loci successfully amplified and showed polymorphism in six species in the tribe Lampsilini. The microsatellite loci developed in this study provide a valuable addition to extant genetic markers for freshwater mussels and can be useful to provide high-level resolution of population genetic parameters for V. ellipsiformis. Such information will be of great value for resource managers developing and prioritizing conservation strategies for imperiled mussel species.

This paper describes the photophysical properties of a series of seven selected examples of 5-(alkyl/aryl/heteroaryl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines (3), which contain alkyl, aryl, and heteroaryl substituents attached to the scaffolds of 3. Given the electron-donor groups and -withdrawing groups, the optical absorption and emission in the solid state and solution showed interesting results. Absorption UV–Vis and fluorescence properties in several solvents of a pyrazolo[1,5-a]pyrimidines series were investigated, and all derivatives were absorbed in the ultraviolet region despite presenting higher quantum emission fluorescence yields in solution and moderate emission in the solid state. Moreover, the solid-state thermal stability of compounds 3a–g was assessed using thermogravimetric analysis. The thermal decomposition profile showed a single step with almost 100% mass loss for all compounds 3. Additionally, the values of T0.05 are considerably low (72–187 °C), especially for compound 3a (72 °C), indicating low thermal stability for this series of pyrazolo[1,5-a]pyrimidines.

Fiber intake is associated with a lower risk for Alzheimer´s disease (AD) in older adults. Intake of plant-based diets rich in soluble fiber promotes the production of short-chain fatty acids (SCFAs: butyrate, acetate, propionate) by gut bacteria. Butyrate administration has antiinflammatory actions, but propionate promotes neuroinflammation. In AD patients, gut microbiota dysbiosis is a common feature even in the prodromal stages of the disease. It is unclear whether the neuroprotective effects of fiber intake rely on gut microbiota modifications and specific actions of SCFAs in brain cells. Here, we show that restoration of the gut microbiota dysbiosis through the intake of soluble fiber resulted in lower propionate and higher butyrate production, reduced astrocyte activation and improved cognitive function in 6-month-old male APP/PS1 mice. The neuroprotective effects were lost in antibiotic-treated mice. Moreover, propionate promoted higher glycolysis and mitochondrial respiration in astrocytes, while butyrate induced a more quiescent metabolism. Therefore, fiber intake neuroprotective action depends on the modulation of butyrate/propionate production by gut bacteria. Our data further support and provide a mechanism to explain the beneficial effects of dietary interventions rich in soluble fiber to prevent dementia and AD. Fiber intake restored the concentration of propionate and butyrate by modulating the composition of gut microbiota in male transgenic (Tg) mice with Alzheimer´s disease. Gut dysbiosis was associated with intestinal damage and high propionate levels in control diet fed-Tg mice. Fiber-rich diet restored intestinal integrity and promoted the abundance of butyrate-producing bacteria. Butyrate concentration was associated with better cognitive performance in fiber-fed Tg mice. A fiber-rich diet may prevent the development of a dysbiotic microbiome and the related cognitive dysfunction in people at risk of developing Alzheimer´s disease.

Com intuito de alimentar estudos profícuos sobre a Tratadística de Arte que vêm sendo desenvolvidos nos diferentes centros de pesquisa brasileiros, o presente dossiê tem por escopo contemplar esta ampla temática. A partir das categorias das Artes e das Letras, busca-se investigar as análises exegéticas dos tratados, com origens e tempos distintos, tomando-se como referência a formulação de preceitos e as assimilações e desdobramentos verificáveis nos campos da teoria e da prática.

Iron (Fe) and manganese (Mn) are metals commonly found at high concentrations in underground water. These metals are essential for the good functioning of living organisms, but high concentrations lead to imbalance, potentiating the appearance of pathologies. This study aimed to evaluate the effect of exposure to naturally occurring metals in groundwater, using zebrafish (Danio rerio) as an experimental model. Thus, zebrafish were exposed to Fe (0.8 and 1.3 mg/L), Mn (0.2 and 0.4 mg/L), and groundwater collected from deep tube wells with Fe and Mn (Fe 0.8/Mn 0.2 mg/L and Fe 1.3/Mn 0.4 mg/L) for 30 days. Bioaccumulation of these metals has been demonstrated in the livers and muscles of zebrafish. Acetylcholinesterase activity changed only in zebrafish muscles in all groups. Sulfhydryl levels changed mainly in the group Mn 0.4. SOD/CAT ratio decreased in the groups Fe 0.8 and 1.3, Mn 0.4, and Fe 0.8/Mn 0.4. An increase in the frequency of micronucleus in all groups was shown as a consequence of these changes. Behavioral parameters (time and distance traveled, mean speed, turn angle, latency, and number of crossings between compartments) have also changed, mainly in the groups Fe 1.3, Mn 0.4, and Fe 1.3/Mn 0.4. Therefore, long-term exposure to Fe and Mn, even at not so high concentrations, may cause biochemical, genotoxic, and behavioral changes in zebrafish.

Introdução: O carcinoma peniano é um tumor maligno localizado no órgão sexual masculino. É considerado raro, visto que representa apenas 2% do total dos cânceres que afetam o homem. É mais frequente em indivíduos acima de 50 anos e apresenta como principal causa a má higiene íntima. Este relato aborda as principais características desta patologia e como pode ser realizado seu manejo na atenção primária. Objetivo: Através do relato de caso de carcinoma peniano, discutir o curso clínico da doença, os problemas sociais relacionados e sua importância na atenção primária. Metodologia: O estudo foi construído a partir de uma opção metodológica de natureza qualitativa, com caráter exploratório e estratégia descritiva. Resultados: O carcinoma peniano é uma neoplasia rara, cujo tratamento, muitas vezes mutilante, causa efeitos físicos e mentais devastadores nos pacientes. Além disso, há um certo atraso diagnóstico por parte dos doentes, devido ao medo do homem de se expor. Paciente do sexo masculino, com 60 anos de idade, apresentou lesão vegetante peniana, com crescimento progressivo e sem prurido associado. Conclusões: O paciente apresentou as manifestações clínicas mais frequentes do carcinoma peniano, sendo realizada investigação anatomopatológica para confirmar o diagnóstico.

Introdução: a síndrome de Rett é uma desordem rara do desenvolvimento neurológico, mas pode passar despercebida pela atenção primária à saúde (APS) caso não haja uma boa suspeita diagnóstica. Objetivo: através do relato de caso de Síndrome de Rett, discutir o curso clínico da doença, os problemas sociais relacionados e a importância da APS no seu rastreio e diagnóstico. Metodologia: o estudo foi construído a partir de uma opção metodológica de natureza qualitativa, com caráter exploratório e estratégia descritiva. Resultados: a síndrome de Rett é uma doença de herança dominante ligada ao cromossomo X, causada por mutações no gene MECP2. Paciente do sexo feminino, com 2 anos de idade, apresentou atraso no desenvolvimento neuropsicomotor e iniciou com quadro de episódios convulsivos. Conclusões: a paciente apresentou as características mais comuns da síndrome de Rett, sendo realizada investigação genética para confirmar o diagnóstico.

Objetivos: Realizar um levantamento de estudos nacionais sobre o impacto dos consultórios na rua frente à população em situação de rua. Metodologia: Revisão integrativa com a seguinte questão norteadora “Qual a importância dos consultórios de rua?”. A base de dados utilizados foi a Biblioteca Virtual em Saúde (BVS). A amostra final dessa revisão foi composta de oito artigos. Resultados e discussões: Após a análise do material foi possível estabelecer cinco categorias analíticas: A intersetorialidade na rede de atenção à saúde: dificuldades relacionadas ao não-lugar do morador de rua; Consultório na rua como porta de entrada: O elo da população em situação de rua com a atenção primária a saúde; O vínculo como estratégia para a abordagem na redução de danos e educação em saúde; O estigma e o auto-estigma relacionado ao População em Situação de Rua. Conclusões: Os consultórios na rua têm grande impacto no processo terapêutico principalmente como porta de entrada na Atenção Básica de Saúde. Os obstáculos encontrados estão relacionados à barreira social e burocrática dentro do processo de intersetorialidade. O vínculo, processo de redução de danos e educação em saúde, são ferramentas de eficiente aproveitamento dentro dos processos terapêuticos.

O presente artigo apresenta os principais achados do projeto de pesquisa “Os Dados e o Vírus” (que acompanhou e documentou a utilização de tecnologias da informação e de comunicação - TICs para o combate à pandemia da Covid-19). Considerando que esses usos fomentaram o debate sobre a legitimidade dessas tecnologias, o artigo também oferece uma análise, voltada para o caso brasileiro, sobre como o quadro institucional da proteção de dados no país foi afetado pela pauta. São descritas as principais tecnologias baseadas em coleta e tratamento de dados utilizadas em nível global e os principais exemplos de adoção no Brasil. Foram abordadas também as tensões judiciais provocadas por esse usos e pelas tentativas de compartilhamento de dados pessoais no contexto da Covid-19 (Ação Popular nº 1019257-34.2020.8.26.0053 e da ADI 6387). Em seguida, foram analisados os impactos desses debates e ações judiciais sobre a matéria de proteção de dados no país. Dentre as conclusões, destaca-se o fortalecimento desse quadro institucional, contrariando as preocupações iniciais de que o avanço das tecnologias em questão o enfraquecesse.

The present work reports the biological assays between synthetic BF2-naphtyridine complexes and four proteins: human serum albumin (HSA), calf-thymus DNA (CT-DNA), tyrosinase and acetylcholinesterase enzymes via spectroscopic analysis at physiological conditions, combined with molecular docking simulations. The BF2-complexes presented spontaneous and moderate binding ability to HSA through the ground-state association (static fluorescence quenching mechanism). The main binding site is Sudlow's site I (subdomain IIA) and the binding does not perturb significantly both secondary and surface structure of HSA. Despite BF2-complexes showed good binding ability with HSA, these compounds presented weak intercalative ability with CT-DNA (the most conventional and simple model to preliminary studies), except in the case of 1 h, which suggested that the presence of electronic donor groups in both aromatic ring moieties of BF2-complex structure can increase the intercalative ability for DNA strands. Competitive binding displacement assays in the presence of methyl green and molecular docking calculations indicated that the studied compounds interact preferentially in the major groove of DNA. In addition, the assayed compounds presented the ability to activate or inhibit both tyrosinase (the decontrolled activity can induce melanoma carcinoma) or AChE (involved in reactions related to the function of neurotransmitters) enzymes.

espanolLa nutrigenomica ha configurado, en el medio cientifico y popular, como alternativa para prevenir enfermedades, cuya predisposicion determinada geneticamente puede evitarse o estimularse, dependiendo del entorno en el que el individuo se encuentra. El estudio indago el potencial de la nutrigenomica en mitigar o generar vulnerabilidades. El proposito fue establecer el panorama de la nutrigenomica en Brasil desde la perspectiva de la Bioetica. El estudio ha consistido en un mapeo cuantitativo del panorama de la nutrigenomica en el contexto cientifico y popular de Brasil, y en un analisis bibliografico exploratorio con el fin de identificar los agentes y pacientes morales, asi como las vulnerabilidades para promover una reflexion a la luz de la Bioetica. El escenario de la nutrigenomica en Brasil, elaborado desde 18 textos cientificos y 600 contenidos populares, evidencio la prematuridad del area en el contexto cientifico en confronto con una amplia incorporacion por el medio popular. La incorporacion de la Bioetica en el debate se analizo en 44 articulos cientificos, a partir de los que se identificaron como aspectos condicionantes de decisiones del agente moral los contextos filosofico, biologico, cultural, legal y sanitario en los que se encuentra. Se relacionaron las vulnerabilidades y cambios de paradigmas necesarios para implementarlo en Brasil, con la finalidad de mitigar el potencial de generacion de vulnerabilidades. La Bioetica puede y debe tener una actuacion mas amplia y efectiva en los cuestionamientos de la nutrigenomica al normalizar y orientar el desarrollo de esta area prometedora. Asi, debe apuntar a los cambios de paradigmas da ciencia, de los profesionales, del mercado, del paciente y del consumidor para que se supriman los aspectos potenciales de generacion de las vulnerabilidades identificadas y aportar para la calidad de vida de todos los seres vivos de esta y de futuras generaciones. EnglishNutrigenomics has positioned itself, in the scientific and popular context, as an alternative to prevent diseases, which genetically determined predisposition can be avoided or encouraged, depending on the context the individual is at. The study investigated the potential of nutrigenomics in mitigating or generating vulnerabilities. The purpose was to establish the panorama of nutrigenomics in Brazil from the perspective of Bioethics. The study consisted of a quantitative mapping of the nutrigenomics panorama in the scientific and popular context of Brazil, and of an exploratory bibliographic analysis in order to identify moral agents and patients, as well as vulnerabilities to pro- mote reflection in light of Bioethics. The scenario of nutrigenomics in Brazil, built from 18 scientific texts and 600 popular contents, evidenced the prematurity of the area in the scientific context in comparison with a wide incorporation by the popular media. The incorporation of Bioethics in the debate was analyzed in 44 scientific articles, from which the philosophical, biological, cultural, legal and health contexts in which it is found were identified as conditioning aspects of decisions of the moral agent. The vulnerabilities and paradigm changes necessary to implement it in Brazil were related, in order to mitigate the potential for generating vulnerabilities. Bioethics can and should have a broader and more effective action on nutrigenomics questionings by normalizing and guiding the development of this promising area. Thus, it must aim at paradigm shifts in science, professionals, the market, the patient and the consumer so that the potential aspects of generating the identified vulnerabilities are eliminated and contribute to the quality of life of all living beings in the world of this and future generations. portuguesA nutrigenomica tem configurado, no meio cientifico e popular, como alternativa para prevenir doencas, cuja predisposicao determinada geneticamente pode ser evitada ou estimulada, de- pendendo do ambiente no qual o individuo se insere. Este estudo questionou o potencial da nutrigenomica em mitigar ou gerar vulnerabilidades. Objetivou-se tracar o panorama da nutrigenomica no Brasil sob a perspectiva da Bioetica. O estudo consistiu em um mapeamento quantitativo do panora- ma da nutrigenomica no cenario cientifico e popular do Brasil, e em uma analise bibliografica exploratoria com o intuito de identificar os agentes e pacientes morais, bem como as vulnerabilidades com vistas a promover uma reflexao a luz da Bioetica. O cenario da nutrigenomica no Brasil, elaborado a partir de 18 textos cientificos e de 600 conteudos populares, indicou a prematuridade da area no contexto cientifico em confronto com uma ampla incorporacao pelo meio popular. A incorporacao da Bioetica na questao foi analisada em 44 artigos cientificos, a partir dos quais foram identificados como aspectos condicionantes de decisoes do agente moral os contextos filosofico, biologico, cultural, legal e sanitario nos quais se insere. Foram elencadas as vulnerabilidades e mudancas de paradigmas necessarias para sua implementacao no Brasil, a fim de diminuir o potencial de geracao de vulnerabilidades. A Bioetica pode e deve ter uma atuacao mais ampla e efetiva nas questoes da nutrigenomica ao normatizar, balizar e orientar o desenvolvimento dessa area promissora. Assim, deve visar as mudancas de paradigmas da ciencia, dos profissionais, do mercado, do paciente e do consumidor para serem suprimidos os aspectos potenciais de geracao das vulnerabilidades identificadas e contribuir para a qualidade de vida de todos os seres vivos desta e de futuras geracoes.