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High-throughput drug screening microfluidic chip has good biocompatibility and faveriable functional integration, which is the excellent platform for high-throughput screening. Importantly, FRET (Fluorescence Resonance Energy Transfer) technology is the most efficient detection means at present. In this paper, we introduce the development of drug screening microfluidic chip on cellular level and the application of FRET technology on cell detection. Further, we discusse the possibility of FRET applied in the field of microfluidic biochip.

Sr4Al14O25:Eu2+, Dy3+ luminescent phosphor was synthesized for the first time from using cyclodextrin as chelating agent by sol-gel method. The structural characterization, surface morphology and properties of the phosphor were studied. The results revealed that the target phosphor with relatively regular morphology, smaller grain size, pure phase and high crystallinity can be achieved at 1200°C for 4 h in a reducing atmosphere. The average grain size of the Sr4Al14O25:Eu2+, Dy3+ phosphor nanoparticles ranges from 50 to 100 nm . And the phosphorescence in blue-green (483 nm) by Eu2+.

The microenvironment has been shown to regulate cellular functions including cell growth, differentiation, proliferation, migration, cancer development and metastasis. However, the underlying mechanism remains largely unclear. It has been reported that tension force is a key issue for osteogenesis of human mesenchymal stem cells (MSCs) and osteoblasts. In the present study, fibronectin film covered on glass substrate was made into square-shaped micro patterns. Osteoblasts cultured on this geometric substrate first located at the edge of the square. Next day the cells extended to the whole square. The results showed that geometric cues can control the growth of osteoblasts. Possible explanation is that the edge of the square provides higher tension force to the cell. These findings demonstrate that tension force from geometric shape is a positive signal for osteogenesis of osteoblasts and bone remodeling.

The polylactic acids (PLA) scaffolds materials have been used to be the scaffolds materials of bone, cartilage gristle, blood vessel, nerve and skin due to its bioactivity, biocompatibility and biodegradable, today, the porous polylactic acid scaffolds had widely applied to tissue engineering. In the paper, the advance in study of microstructure and biocompatibility for this material were summarized. The lack in study of microstructure and compatibility has been pointed out and some viewpoints for further investigations are also made in this paper.

Artificial neural network (ANN) is widely applied to the modeling of complex systems, which has become a common modeling method in the study of materials science. As the ideal candidates for high temperature structural materials, carbon materials are no doubt involved in fatigue loads, so the study on forecasting fatigue life is meaningful. In this paper, the electrical resistance at various fatigue cycles and level of applied stress of the materials under tensile fatigue loading has been detected, and regarded the fracture or fatigue cycles equal to 106 as fatigue life of carbon materials. On the basis of the electrical resistance value, the fatigue life has been forecasted by applied the ANN. The results indicated that the ANN could forecast the fatigue life of carbon materials well; finally, the applications of ANN in the study of material, such as properties prediction, damage prediction and failure detection were reviewed.

As the ideal candidates for high temperature structural materials, carbon/carbon (C/C) composites are no doubt involved in fatigue loading. Therefore, the study on fatigue behavior is meaningful. In this paper, the research on fatigue behavior of C/C composites was reviewed and the characteristic of fatigue behavior was summarized. Some viewpoints for further investigations for the study on the fatigue behavior of C/C composites are also made in this paper.

Three dimensional braided carbon/carbon composites (3D C/C composites) were fabricated by chemical vapor infiltration. The thermal expansion behavior of these materials with various densities before and after heat treatment was investigated. It is found that PAN-based carbon fibers (CFs) have an obviously negative coefficient of thermal expansion (CTE) after heat treatment at 1 200 ℃. The CTE of the 3D C/C composites is negative from room temperature to 100 ℃ and is proportion to their density. In the temperature range of 100-1 000 ℃,CTE vs. T curves have an almost a constant slope and expansion behavior of the composite is similar to that of pyrocarbon. When the temperature is above 1 000 ℃,a peak is found in the CTE vs. T curves,indicating that expansion of the pyrocarbon is limited by CFs and the thermal expansion behavior of the composites is determined by both CFs and matrix.