The paper presents the design of a wireless communication system for short-range, high-speed, and multi-node information acquisition based on BLE5.0 technology, targeting indoor wearable applications. The system employs the Nordic nRF52832 microcontroller, which integrates BLE5.0 transceivers, as the core, and includes designs for master-slave node communication, data acquisition, hardware circuitry, embedded and upper computer programs. The system is validated through upper computer software for device networking, multi-node data acquisition, and communication speed. The power consumption and communication distance of the devices are tested using a measurement device. The designed multi-node BLE5.0 communication system in this paper provides a technical foundation for the design of relevant short-range IoT applications and has broad application prospects.