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Start Over Author "Pingping Shangguan" Topic general chemistry
1 results on '"Pingping Shangguan"'

1. Monitoring mitochondrial nitroreductase activity in tumors and a hind-limb model of ischemia in mice using a novel activatable NIR fluorescent probe

Author

Xiaosheng Liu, Shuang Zeng, Ming Zhang, Maojun Jiang, Yves S. Kafuti, Pingping Shangguan, Yichu Yu, Qixian Chen, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, and Haidong Li

Subjects
Nitrogen Dioxide, Metals and Alloys, General Chemistry, Nitroreductases, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Mitochondria, Mice, Ischemia, Neoplasms, Materials Chemistry, Ceramics and Composites, Animals, Fluorescent Dyes
Abstract

We report a mitochondria-targeted nitroreductase (NTR)-activated near-infrared fluorescent probe: CS-NO2. Overexpressed NTR in mitochondria was measured with high sensitivity. More importantly, the probe CS-NO2 successfully monitored NTR activity in solid tumors and a hind-limb model of ischemia in mice. This novel finding indicates the promising function of our probe for the diagnosis of solid tumors and hypoxia-associated diseases.

Published
2022

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