1. Improved Biocompatibility and Pharmacokinetics of Silica Nanoparticles by Means of a Lipid Coating: A Multimodality Investigation
- Author
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Matti M. van Schooneveld, Yu Zhou, David P. Cormode, Esad Vucic, Zahi A. Fayad, Klaas Nicolay, Andries Meijerink, Willem J. M. Mulder, Ronald E. Gordon, Joanne Stocks, Rolf Koole, Cheuk Y. Tang, and Medical Biochemistry
- Subjects
Fluorescence-lifetime imaging microscopy ,Materials science ,Biocompatibility ,Nanoparticle ,Biocompatible Materials ,Bioengineering ,Nanotechnology ,02 engineering and technology ,engineering.material ,010402 general chemistry ,01 natural sciences ,Mice ,Microscopy, Electron, Transmission ,Coating ,Animals ,General Materials Science ,Inductively coupled plasma mass spectrometry ,Mechanical Engineering ,General Chemistry ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Lipids ,Magnetic Resonance Imaging ,3. Good health ,0104 chemical sciences ,Mice, Inbred C57BL ,Drug delivery ,engineering ,Nanoparticles ,Molecular imaging ,0210 nano-technology ,Drug carrier - Abstract
Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.
- Published
- 2008
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