Search

Your search keyword '"Aziz Auhmani"' showing total 28 results
Start Over Author "Aziz Auhmani" Topic general chemistry
28 results on '"Aziz Auhmani"'

5. Novel Hydrazono‐2‐Iminothiazolidin‐4‐Ones Based on a Monoterpenic Skeleton as Potential Antitumor Agents: Synthesis, DFT Studies, in Vitro Cytotoxicity, Apoptosis Inducing Properties and Molecular Docking

Author

Mourad Fawzi, Ali Oubella, Az‐Eddine El Mansouri, Abdoullah Bimoussa, El Mostafa Ketatni, Mohamed Saadi, Lahcen El Ammari, Moulay Youssef Ait Itto, Hamid Morjani, and Aziz Auhmani

Subjects
Molecular Structure, Caspase 3, Antineoplastic Agents, Apoptosis, Bioengineering, General Chemistry, General Medicine, Ligands, Biochemistry, Molecular Docking Simulation, Structure-Activity Relationship, Cell Line, Tumor, Humans, Molecular Medicine, Drug Screening Assays, Antitumor, Molecular Biology, Cell Proliferation
Abstract

A series of novel 2-iminothiazolidin-4-one analogs have been synthesized from limonaketone, and structurally characterized by HR-MS

Published
2022
Full Text
View/download PDF

7. Electrochemical and theoretical studies of some monoterpenic thiazolidinones as corrosion inhibitors for steel in acidic media

Author

Aziz Auhmani, Abdellah N'ait Ousidi, Rachid Idouhli, Mohy Eddine Khadiri, My Youssef Ait Itto, A. Abouelfida, and Abdelaziz Benyaich

Subjects
Materials science, Hydrochloric acid, 030206 dentistry, 02 engineering and technology, Surfaces and Interfaces, General Chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, Surfaces, Coatings and Films, Corrosion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adsorption, chemistry, Mechanics of Materials, Materials Chemistry, 0210 nano-technology, Nuclear chemistry
Abstract

This work deals with the study of the inhibition activity of three thiazolidinones (prepared from monoterpenic ketones) on the deterioration of S300 steel in hydrochloric acid solution. The potenti...

Published
2020
Full Text
View/download PDF

9. Synthesis and Antitumor Activity of Novel Heterocyclic Systems with Monoterpenic Skeleton Combining Dichlorocyclopropane and 1,3,4‐Thiadiazole Nucleus

Author

Abdelkhalek Riahi, Aziz Auhmani, Anthony Robert, Moulay Youssef Ait Itto, Mourad Fawzi, Hamid Morjani, Ali Oubella, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Biospectroscopie Translationnelle - EA 7506 (BIOSPECT), Université de Reims Champagne-Ardenne (URCA), Cristallographie, Résonance Magnétique et Modélisations (CRM2), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Antitumor activity, 010405 organic chemistry, Stereochemistry, Chemistry, General Chemistry, 010402 general chemistry, 01 natural sciences, Skeleton (computer programming), 0104 chemical sciences, 3. Good health, medicine.anatomical_structure, 1,3-Dipolar cycloaddition, medicine, [CHIM]Chemical Sciences, Nucleus, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020
Full Text
View/download PDF

10. Crystal structure of ( R )-5-[( R )-3-(4-chlorophenyl)-5-methyl-4,5-dihydroisoxazol-5-yl]-2-methylcyclohex-2-enone

Author

Ali Oubella, My Youssef Ait Itto, Aziz Auhmani, Abdelkhalek Riahi, Jean-Claude Daran, Abdelwahed Auhmani, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
crystal structure, natural products, 030303 biophysics, Crystal structure, pharmaceutical activities, 010403 inorganic & nuclear chemistry, Ring (chemistry), 01 natural sciences, Medicinal chemistry, Crystal, lcsh:Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Column chromatography, [CHIM]Chemical Sciences, General Materials Science, 0303 health sciences, Chemistry, Diastereomer, Absolute configuration, General Chemistry, Condensed Matter Physics, isoxazole derivatives, 3. Good health, 0104 chemical sciences, absolute configuration, lcsh:QD1-999, Proton NMR, Enone
Abstract

The title compound, C17H18ClNO2, was prepared and isolated as a pure diastereoisomer, using column chromatography followed by a succession of fractional crystallizations. Its exact structure was fully identified via 1H NMR and confirmed by X-ray diffraction. It is built up from a central five-membered dihydroisoxazole ring to which a p-chlorophenyl group and a cyclohex-2-enone ring are attached in the 3 and 5 positions. The cyclohex-2-one and isoxazoline rings each exhibit an envelope conformation. The crystal packing features C—H...O, C—H...N and C—H...π interactions, which generate a three-dimensional network.

Published
2020
Full Text
View/download PDF

11. Crystal structure of (4bS,8aR)-1-isopropyl-4b,8,8-trimethyl-7-oxo-4b,7,8,8a,9,10-hexahydrophenanthren-2-yl acetate

Author

Aziz Auhmani, El Mostafa Ketatni, Abdelkhalek Riahi, Yassine Laamari, Moulay Youssef Ait Itto, and Sylviane Chevreux

Subjects
phenanthrene, crystal structure, natural product, Crystallography, Chemistry, Hydrogen bond, General Chemistry, Crystal structure, 010402 general chemistry, 010403 inorganic & nuclear chemistry, Condensed Matter Physics, Ring (chemistry), HEXA, 01 natural sciences, 0104 chemical sciences, Crystal, C—H...π interactions, QD901-999, Atom, General Materials Science, C—H...O hydrogen bond, Isopropyl
Abstract

The title compound, C22H28O3, was prepared by a direct acetylation reaction of naturally occurring totarolenone. The molecule contains three fused rings, which exhibit different conformations. The central ring has a half-chair conformation, while the non-aromatic oxo-substituted ring has a screw-boat conformation. In the crystal, molecules are linked by C—H...O hydrogen bonds and C—H...π interactions, forming sheets parallel to the bc plane. The carbonyl O atoms and the C atom at the 6-position of the cyclohexene ring are each disordered over two sets of sites with major occupancy components of 0.63 (7) and 0.793 (14), respectively.

Published
2018

12. Crystal structure of (1S,3R,8R,9R)-2,2-dichloro-3,7,7-trimethyl-10-methylenetricyclo[6.4.0.01,3]dodecan-9-ol

Author

Ahmed Benzalim, Aziz Auhmani, Abdoullah Bimoussa, My Youssef Ait Itto, Jean-Claude Daran, Abdelwahed Auhmani, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
crystal structure, natural products, Stereochemistry, asymmetric synthesis, Cyclohexane conformation, Crystal structure, 010402 general chemistry, 010403 inorganic & nuclear chemistry, Ring (chemistry), 01 natural sciences, Medicinal chemistry, Research Communications, sesquiterpenes, [CHIM.COOR]Chemical Sciences/Coordination chemistry, General Materials Science, chemistry.chemical_classification, Crystallography, biology, Chemistry, Hydrogen bond, Alkene, Absolute configuration, Enantioselective synthesis, General Chemistry, Condensed Matter Physics, biology.organism_classification, 3. Good health, 0104 chemical sciences, absolute configuration, QD901-999, Tetra
Abstract

The title compound was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di­chloro-3,7,7,10-tetra­methyl-9,10-ep­oxy­tri­cyclo­[6.4.0.01,3]dodecane with a concentrated solution of hydro­bromic acid. It is built up from three fused rings: a cyclo­heptane ring, a cyclo­hexyl ring bearing alkene and hy­droxy substituents, and a cyclo­propane ring bearing two chlorine atoms., The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di­chloro-3,7,7,10-tetra­methyl-9,10-ep­oxy­tri­cyclo­[6.4.0.01,3]dodecane with a concentrated solution of hydro­bromic acid. It is built up from three fused rings: a cyclo­heptane ring, a cyclo­hexyl ring bearing alkene and hy­droxy substituents, and a cyclo­propane ring bearing two chlorine atoms. The asymmetric unit contains two mol­ecules linked by an O—H⋯O hydrogen bond. In the crystal, further O—H⋯O hydrogen bonds build up an R 4 4(8) cyclic tetra­mer. One of the mol­ecules presents disorder that affects the seven-membered ring. In both mol­ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter­mediate between boat and twist-boat for the non-disordered mol­ecule and either a chair or boat and twist-boat for the disordered mol­ecule owing to the disorder. The absolute configuration for both mol­ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis.

Published
2016
Full Text
View/download PDF

13. Crystal structure of 2-isopropyl-4-methoxy-5-methylphenyl 4-methylbenzenesulfonate

Author

Aziz Auhmani, Jean-Claude Daran, Mostafa Kouili, Abdelwahed Auhmani, My Youssef Ait Itto, Yassine Laamari, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Sultan Moulay Slimane (USMS )

Subjects
tosyl­ation of alcohols, Organic synthesis, Crystal structure, 010402 general chemistry, 010403 inorganic & nuclear chemistry, Ring (chemistry), 01 natural sciences, Medicinal chemistry, Research Communications, Crystal, chemistry.chemical_compound, Drug synthesis, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Tosylation of alcohols, Meroterpene, Crystallography, General Chemistry, Meth, Condensed Matter Physics, 3. Good health, 0104 chemical sciences, Sulfonate, chemistry, QD901-999, Isopropyl
Abstract

The title compound, an hemisynthetic product, was obtained by the tosyl­ation reaction of the naturally occurring meroterpene p-meth­oxy­thymol 1., The title compound, C18H22O4S, an hemisynthetic product, was obtained by the tosyl­ation reaction of the naturally occurring meroterpene p-meth­oxy­thymol. The mol­ecule comprises a tetra­substitued phenyl ring linked to a toluene­sulfonate through one of its O atoms. In the crystal, C—H⋯O and C—H⋯π inter­actions link the mol­ecules, forming a three-dimensional network.

Published
2018
Full Text
View/download PDF

14. Crystal structure of dimethyl 2-((2 Z ,5 Z )-5-(2-methoxy-2-oxoethylidene)-2-{( E )-[2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enylidene]hydrazinylidene}-4-oxothiazolidin-3-yl)fumarate

Author

Abdelwahed Auhmani, Aziz Auhmani, Abdellah N'ait Ousidi, Jean-Claude Daran, Abdelkhalek Riahi, My Youssef Ait Itto, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Stereochemistry, Hydrazone, Crystal structure, 010403 inorganic & nuclear chemistry, Ring (chemistry), 01 natural sciences, Natural product, Research Communications, lcsh:Chemistry, chemistry.chemical_compound, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry, chemistry.chemical_classification, 010405 organic chemistry, General Chemistry, Meth, Condensed Matter Physics, 3. Good health, 0104 chemical sciences, Thiazolidine derivatives, chemistry, lcsh:QD1-999, thia­zolidine derivatives, Heterocyclic compounds, Derivative (chemistry)
Abstract

The crystal structure of the title compound, dimethyl 2-((2Z,5Z)-5-(2-meth­oxy-2-oxo­ethyl­idene)-2-{(E)-[2-methyl-5-(prop-1-en-2-yl)cyclo­hex-2-enyl­idene]hydrazinyl­idene}-4-oxo­thia­zolidin-3-yl)fumarate displays a conformational disorder which inverts the configuration of the chiral C atom within the cyclo­hexyl­idene ring., The crystal structure and the conformation of the title compound, C22H27N3O7S, were determined from the synthetic pathway and by X-ray analysis. This compound is a new 4-thia­zolidinone derivative prepared and isolated as pure product from thio­semicarbazone carvone. The mol­ecule is built up from an oxo­thia­zolidine ring tetra­substituted by a meth­oxy–oxo­ethyl­idene, a maleate, an oxygen and a cyclo­hexyl­idene–hydrazone. The cyclo­hexyl­idene ring is statistically disordered over two positions, resulting in an inversion of configuration for the substituted carbon.

Published
2017
Full Text
View/download PDF

15. Crystal structure of 2-[(3aS,6R)-3,3,6-trimethyl-3,3a,4,5,6,7-hexahydro-2H-indazol-2-yl]thiazol-4(5H)-one

Author

Jean-Claude Daran, Abdellah N'ait Ousidi, Auhmani Abdelwahed, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
crystal structure, Stereochemistry, C—H⋯O hydrogen bonding, Crystal structure, Pyrazole, 010402 general chemistry, Ring (chemistry), C—H⋯π inter­actions, 01 natural sciences, thiazolidinone, Research Communications, Crystal, chemistry.chemical_compound, C—H...π interactions, heterocyclic compounds, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry, C—H...O hydrogen bonding, Indazole, Crystallography, 010405 organic chemistry, Hydrogen bond, General Chemistry, Condensed Matter Physics, HEXA, thia­zolidinone, 3. Good health, 0104 chemical sciences, chemistry, QD901-999, indazole, absolute structure, Derivative (chemistry)
Abstract

The absolute structure of the title compound was determined from the synthetic pathway and by resonant scattering. The compound is a new thia­zolidin-4-one derivative, prepared from (R)-thio­semicarbazone pulegone, and was isolated on crystallization from ethanol as the pure (3aS,6R)-diastereisomer., The title compound, C13H19N3OS, is a new thia­zolidin-4-one derivative prepared and isolated as the pure (3aS,6R)-diastereisomer from (R)-thio­semicarbazone pulegone. It crystallized with two independent mol­ecules (A and B) in the asymmetric unit. The compound is composed of a hexhydro­indazole ring system (viz. a five-membered di­hydro­pyrazole ring fused to a cyclo­hexyl ring) with a thia­zole-4-one ring system attached to one of the pyrazole N atoms (at position 2). The overall geometry of the two mol­ecules differs slightly, with the mean planes of the pyrazole and thia­zole rings being inclined to one another by 10.4 (1)° in mol­ecule A and 0.9 (1)° in mol­ecule B. In the crystal, the A and B mol­ecules are linked via C—H⋯O hydrogen bonds, forming slabs parallel to the ab plane. There are C—H⋯π inter­actions present within the layers, and between the layers, so forming a three-dimensional structure.

Published
2016
Full Text
View/download PDF

16. Crystal structure of (1R,2S,4R,7R,8S,9R)-3,3-dichloro-8,9-epoxy-4,8,12,12-tetramethyltricyclo[5.5.0.0(2,4)]dodecane

Author

Ahmed Benzalim, Aziz Auhmani, Abdelwahed Auhmani, Jean-Claude Daran, My Youssef Ait Itto, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
crystal structure, Dodecane, natural products, Epoxide, Crystal structure, 010402 general chemistry, Ring (chemistry), Bioinformatics, 01 natural sciences, lcsh:Chemistry, chemistry.chemical_compound, Group (periodic table), General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry, 010405 organic chemistry, Absolute configuration, Atom (order theory), General Chemistry, Epoxy, Condensed Matter Physics, Data Reports, 0104 chemical sciences, 3. Good health, Crystallography, absolute configuration, chemistry, lcsh:QD1-999, visual_art, visual_art.visual_art_medium, epoxide
Abstract

The title compound, C16H24Cl2O, is built up from two fused six- and seven-membered rings which bear a dichlorocyclopropane group and an epoxy group, respectively. In the molecule, the six-membered ring adopts an envelope configuration with the C atom linking the epoxy ring at the flap, while the seven-membered ring adopts a boat–sofa conformation.

Published
2015
Full Text
View/download PDF

17. (1S,3S,8R,9S,10R)-9,10-Ep-oxy-3,7,7,10-tetra-methyl-tri-cyclo-[6.4.0.0(1,3)]dodeca-ne

Author

Aziz Auhmani, Abdoullah Bimoussa, My Youssef Ait Itto, Jean-Claude Daran, Abdelwahed Auhmani, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
biology, Chemistry, Cyclohexane conformation, Intermolecular force, General Chemistry, Condensed Matter Physics, Bioinformatics, biology.organism_classification, Ring (chemistry), Organic Papers, 3. Good health, Crystal, lcsh:Chemistry, Crystallography, lcsh:QD1-999, Tetra, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry
Abstract

The title compound, C16H26O, was synthesized by treating (1S,3S,8R)-3,7,7,10-tetramethyltricyclo[6.4.0.01,3]dodec-9-ene with metachloroperbenzoic acid. The molecule is built up from two fused six- and seven-membered rings. The six-membered ring has a half-chair conformation, whereas the seven-membered ring displays a boat conformation. In the crystal, there are no significant intermolecular interactions present.

Published
2014
Full Text
View/download PDF

18. (4bS,8aS)-1-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-yl benzoate

Author

Jean-Claude Daran, Abdelwahed Auhmani, My Youssef Ait Itto, Aziz Auhmani, Radouane Oubabi, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Meroterpene, crystal structure, Crystallography, 010405 organic chemistry, Chemistry, Totarol, Cyclohexane conformation, General Chemistry, Dihedral angle, 010403 inorganic & nuclear chemistry, Condensed Matter Physics, Ring (chemistry), Bioinformatics, Organic Papers, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, QD901-999, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Flack parameter, Chirality (chemistry), Isopropyl
Abstract

The title compound, C27H34O2, was hemisynthesized through direct benzoylation of the naturally occurring meroterpene totarol. The central fused six-membered ring has a half-chair conformation, whereas the terminal six-membered ring displays a chair conformation. The dihedral angle between the fused benzene ring and the benzoyl benzene ring is 73.05 (14)°. TheS,Schirality of the molecule is consistent with the synthetic pathway, and confirmed by the refinement of the Flack parameter.

Published
2014
Full Text
View/download PDF

19. Absolute configuration of (1S,3R,8R)-10-bromomethyl-2,2-dichloro-3,7,7-trimethyltricyclo[6.4.0.01,3]dodec-9-ene

Author

Abdelwahed Auhmani, My Youssef Ait Itto, Jean-Claude Daran, Abdoullah Bimoussa, and Aziz Auhmani

Subjects
Crystallography, Chemistry, Absolute configuration, General Chemistry, Condensed Matter Physics, computer.software_genre, Ring (chemistry), Organic Papers, Crystal, symbols.namesake, QD901-999, symbols, General Materials Science, Data mining, van der Waals force, computer, Ene reaction
Abstract

The absolute configuration of the title compound, C16H23BrCl2, has been deduced from the chemical pathway and fully confirmed by refinement of the Flack and Hooft parameters. The six-membered ring adopts a half-chair conformation, whereas the seven-membered ring is a twisted chair. The molecular packing within the crystal is stabilized only by van der Waals interactions.

Published
2013

21. (1S,2S,3R,6S,7R)-3,6-Epoxyhimachalane-2,7-diol

Author

Aziz Auhmani, M. Dakir, E. Kossareva, H. El Jamili, A. Benharref, and Marcel Pierrot

Subjects
chemistry.chemical_compound, Crystallography, Chemistry, Hydrogen bond, Diol, Intermolecular force, Molecule, General Materials Science, General Chemistry, Condensed Matter Physics
Abstract

The stereochemistry of the title compound, C15H26O3, has been established. The compound crystallizes with three molecules in the asymmetric unit and significant variations in the bond distances and angles are reported. Intermolecular hydrogen bonds are observed between the hydroxyl groups.

Published
2001
Full Text
View/download PDF

22. 1,4a-Dimethyl-6-methyl-ene-5-(5,5,6,6-tetra-cyano-2-methyl-cyclo-hex-2-enylmeth-yl)deca-hydro-naphthalene-1-carboxylic acid: a trans-communic acid derivative

Author

Aziz Auhmani, Nezha Rejouani, My Youssef Ait Itto, Ahmed Benharref, and Jean-Claude Daran

Subjects
chemistry.chemical_classification, Crystallography, biology, Chemistry, Hydrogen bond, Carboxylic acid, Cyclohexane conformation, General Chemistry, Condensed Matter Physics, biology.organism_classification, Bioinformatics, Ring (chemistry), Medicinal chemistry, Organic Papers, Catalysis, chemistry.chemical_compound, QD901-999, Tetra, General Materials Science, Ene reaction, Derivative (chemistry)
Abstract

In the search for cancer chemopreventive agents, we have studied the Diels-Alder reaction of trans-communic acid with tetra-cyano-ethyl-ene in the presence of SiO(2) as catalyst. The title cycloadduct, C(26)H(30)N(4)O(2), was obtained in 75% yield. The mol-ecules are arranged in pairs through O-H⋯O hydrogen bonds, forming an R(2) (2)(8) ring motif. Both the fused cyclohexyl rings adopt a chair conformation, whereas the nonfused ring adopts a half-chair conformation.

Published
2007

23. (4aS,6cS)-8-Hydroxy-9-isopropyl-4,4,6c-trimethyl-1,2,3,4,4a,5,6, 6c-octahydrophenanthren-3-one

Author

Aziz Auhmani, Celia Maya, Noureddine Mazoir, Abdellah Zeroual, Ahmed Benharref, and Moha Berraho

Subjects
Supplementary data, Chemistry, T = 298 K, R factor = 0.038, General Chemistry, computer.file_format, wR factor = 0.105, Condensed Matter Physics, mean σ(C–C) = 0.002 Å, Crystallographic Information File, Crystallography, General Materials Science, Data-to-parameter ratio = 15.5, Single-crystal X-ray study, computer, Isopropyl
Abstract

7 pags, 1 fig, 1 tab. -- Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: FJ2021). -- Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807022258/fj2021sup1.cif Contains datablocks I, globaI . -- Structure factor file (CIF format) https://doi.org/10.1107/S1600536807022258/fj2021Isup2.hkl Contains datablock I, The title compound, C20H28O2, is a diterpenoid isolated from the wood of the Tetraclinis articulata plant. The molecule contains three fused rings which exhibit different conformations. The non-aromatic oxo-substituted ring has a chair conformation, while the central ring has an envelope conformation. The crystal structure is stabilized by O - H⋯O hydrogen bonds. © International Union of Crystallography 2007.

Published
2007

24. (1R,3S,8R)-3,7,7,10-Tetra­methyl­tri­cyclo­[6.4.0.01,3]dodec-9-en-11-one

Author

Aziz Auhmani, Jean-Claude Daran, My Youssef Ait Itto, Abdoullah Bimoussa, Auhmani Abdelwahed, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Crystallography, biology, Chemistry, Hydrogen bond, Stereochemistry, Cyclohexane conformation, education, Absolute configuration, General Chemistry, Condensed Matter Physics, biology.organism_classification, Bioinformatics, Ring (chemistry), Carbonyl group, Organic Papers, 3. Good health, chemistry.chemical_compound, QD901-999, Group (periodic table), Atom, Tetra, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry
Abstract

The absolute configuration of the title compound, C16H24O, has been deduced from the chemical pathway. The six-membered ring has a roughly half-chair conformation with the quaternary C atom as the flap. The seven-membered ring displays a chair conformation. In the crystal, there is a weak C—H...O hydrogen bond between the methylene group of the cyclopropane ring and the carbonyl group of a screw-axis-related molecule, which builds up a zigzag-like chain along the b-axis direction.

Published
2013
Full Text
View/download PDF

25. (4aS*,10aR*)-7-Hydroxy-8-isopropyl-1,1,4a-trimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-one

Author

Moha Berraho, Aziz Auhmani, Noureddine Mazoir, Abdellah Zeroual, and Ahmed Benharref

Subjects
Totarolone, boats, boats.ship_class, Stereochemistry, Chemistry, Hydrogen bond, Cyclohexane conformation, Articulata, General Materials Science, General Chemistry, Condensed Matter Physics, Ring (chemistry), Isopropyl
Abstract

The title compound, C20H28O2, is a new totarolone which was isolated from Tetra­clinis articulata wood. The mol­ecule forms an extended sheet of three fused rings which exhibit different conformations. The non-aromatic oxo-substituted ring has a screw boat conformation, while the central ring has a half-chair conformation. Mol­ecules are linked to each other by inter­molecular O—H⋯O hydrogen bonds involving carbonyl and hydroxyl groups.

Published
2007
Full Text
View/download PDF

26. (4bS,8aS)-1-Isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-yl acetate

Author

Radouane Oubabi, Aziz Auhmani, My Youssef Ait Itto, Abdelwahed Auhmani, Jean-Claude Daran, Laboratoire de Physico-Chimie Moléculaire et Synthèse Organique, Département de Chimie, Faculté des Sciences, Faculté des Sciences Semlalia Marrakech, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
lcsh:Chemistry, lcsh:QD1-999, [CHIM.COOR]Chemical Sciences/Coordination chemistry, General Materials Science, General Chemistry, Condensed Matter Physics, Organic Papers
Abstract

The hemisynthesis of the title compound, C22H32O2, was carried out through direct acetylation reaction of the naturally occurring diterpene totarol [systematic name: (4bS,8aS)-4b,8,8-trimethyl-1-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthren-2-ol]. The molecule is built up from three fused six membered rings, one saturated and two unsaturated. The central unsaturated ring has a half-chair conformation, whereas the other unsaturated ring displays a chair conformation. The absolute configuration is deduced from the chemical pathway. The value of the Hooft parameter [−0.10 (6)] allowed this absolute configuration to be confirmed.

Published
2014
Full Text
View/download PDF

27. (1R,6S,7R)-Himachal-2-ène-6,7-diol

Author

Aziz Auhmani, A. Benharref, Marcel Pierrot, E. Kossareva, H. El Jamili, and M. Dakir

Subjects
chemistry.chemical_compound, chemistry, Hydrogen bond, Intermolecular force, Diol, Organic chemistry, General Materials Science, General Chemistry, Condensed Matter Physics, Ene reaction
Abstract

The stereochemistry of the title compound, C15H26O2, has been established. Intermolecular hydrogen bonds are observed between the hydroxyl groups.

Published
2001
Full Text
View/download PDF

28. 6-Hydroxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one

Author

Ahmed Benharref, Jean-Claude Daran, Aziz Auhmani, Nezha Rajouani, and My Youssef Ait Itto

Subjects
Crystallography, Chemistry, Hydrogen bond, Cyclohexane conformation, General Chemistry, Crystal structure, Carbon-13 NMR, Condensed Matter Physics, Bioinformatics, Ring (chemistry), HEXA, Organic Papers, Medicinal chemistry, chemistry.chemical_compound, QD901-999, General Materials Science, Isopropyl, Abietane
Abstract

The title compound, C(20)H(28)O(2), commonly named Sugiol, is a natural oxygenated diterpene that we have isolated for the first time from a hexane extract of the fruits of Juniperus Oxycedrus L. Its X-ray crystal structure determination confirms an abietane skeleton which was predicted by spectroscopic analysis, mainly by (1)H and (13)C NMR. The cyclo-hexane ring adopts a flattened chair conformation, while the cyclo-hexene ring adopts an envelope conformation. The mol-ecules are linked through O-H⋯O hydrogen bonds to form a zigzag chain extending parallel to the c axis.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results