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Highlights: [•] ADAM 10 is increased in OSCC compared to normal oral mucosa and dysplasia. [•] Oral cancer cell lines show increased ADAM 10 expression compared to normal cells. [•] Reduction of ADAM 10 in αvβ6 over-expressing cells decreases migration and invasion. [•] Adhesion to ADAM 10 leads to altered MMP activity in αv integrin expressing cells. [ABSTRACT FROM AUTHOR]

Abstract: Alterations in the levels of molecules which interact with the extracellular matrix, such as integrins, are associated with invasion of oral squamous cell carcinomas (OSCC). The molecular mechanisms underlying dysregulation of integrin expression in OSCC, however, remain unclear. Here, we show that microRNA-124, a small non-coding RNA down-regulated in OSCC, is able to downregulate expression of integrin beta-1 (ITGB1) by interacting with its 3′ untranslated region. Over-expression of miR-124 attenuates endogenous ITGB1 expression and reduces the adherence and motility of OSCC cells, suggesting disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression. [ABSTRACT FROM AUTHOR]